RBM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)4.89006733
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80239614
3response to pheromone (GO:0019236)4.42821662
4platelet dense granule organization (GO:0060155)4.17398776
5DNA double-strand break processing (GO:0000729)4.09499296
6maturation of 5.8S rRNA (GO:0000460)4.07884106
7proteasome assembly (GO:0043248)3.91002200
8positive regulation of interferon-alpha production (GO:0032727)3.88502625
9regulation of interferon-alpha production (GO:0032647)3.64563987
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63149655
11mitochondrial respiratory chain complex I assembly (GO:0032981)3.63149655
12NADH dehydrogenase complex assembly (GO:0010257)3.63149655
13RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.61536395
14protein-cofactor linkage (GO:0018065)3.59935673
15neutrophil activation involved in immune response (GO:0002283)3.56783500
16regulation of mitotic spindle checkpoint (GO:1903504)3.48468074
17regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.48468074
18immunoglobulin mediated immune response (GO:0016064)3.45326035
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.44952014
20nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40896080
21replication fork processing (GO:0031297)3.38601171
22protein complex biogenesis (GO:0070271)3.37818158
23response to peptidoglycan (GO:0032494)3.36011079
24L-fucose catabolic process (GO:0042355)3.32469933
25fucose catabolic process (GO:0019317)3.32469933
26L-fucose metabolic process (GO:0042354)3.32469933
27respiratory chain complex IV assembly (GO:0008535)3.31357771
28positive regulation of chemokine biosynthetic process (GO:0045080)3.29061411
29tryptophan catabolic process (GO:0006569)3.28336146
30indole-containing compound catabolic process (GO:0042436)3.28336146
31indolalkylamine catabolic process (GO:0046218)3.28336146
32DNA deamination (GO:0045006)3.28095578
33mitochondrial respiratory chain complex assembly (GO:0033108)3.28066545
34positive regulation of interferon-beta production (GO:0032728)3.21082034
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.18837723
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.18837723
37NIK/NF-kappaB signaling (GO:0038061)3.18215811
38cellular response to zinc ion (GO:0071294)3.17231838
39pseudouridine synthesis (GO:0001522)3.15772349
40regulation of chemokine biosynthetic process (GO:0045073)3.14694117
41B cell mediated immunity (GO:0019724)3.04733990
42cellular response to virus (GO:0098586)3.04197526
43production of molecular mediator involved in inflammatory response (GO:0002532)3.03902520
44chromatin remodeling at centromere (GO:0031055)3.02506901
45regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.02500633
46kynurenine metabolic process (GO:0070189)3.01120158
47negative regulation of DNA-dependent DNA replication (GO:2000104)3.01034600
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00962426
49sulfation (GO:0051923)3.00663222
50somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.99575090
51isotype switching (GO:0045190)2.99575090
52somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.99575090
53respiratory burst (GO:0045730)2.99392695
54CENP-A containing nucleosome assembly (GO:0034080)2.99356680
55regulation of cilium movement (GO:0003352)2.99091544
56rRNA methylation (GO:0031167)2.98676502
57neural tube formation (GO:0001841)2.98670689
58ribosomal small subunit assembly (GO:0000028)2.98368144
59protein K6-linked ubiquitination (GO:0085020)2.97513964
60antigen processing and presentation of endogenous antigen (GO:0019883)2.97432268
61peptidyl-histidine modification (GO:0018202)2.96156537
62centriole replication (GO:0007099)2.92772700
63regulation of glucokinase activity (GO:0033131)2.90976372
64regulation of hexokinase activity (GO:1903299)2.90976372
65positive regulation of gamma-delta T cell activation (GO:0046645)2.89905759
66cellular ketone body metabolic process (GO:0046950)2.89709301
67response to interferon-beta (GO:0035456)2.89345898
68serotonin receptor signaling pathway (GO:0007210)2.89186742
69rRNA modification (GO:0000154)2.88808847
70cysteine metabolic process (GO:0006534)2.87464457
71cullin deneddylation (GO:0010388)2.86802925
72histone mRNA metabolic process (GO:0008334)2.84161233
73histone exchange (GO:0043486)2.83838569
74reciprocal DNA recombination (GO:0035825)2.83687940
75reciprocal meiotic recombination (GO:0007131)2.83687940
76Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83438150
77organelle disassembly (GO:1903008)2.82716136
78regulation of helicase activity (GO:0051095)2.82485442
79regulation of centriole replication (GO:0046599)2.81490804
80protein neddylation (GO:0045116)2.81233890
81cytochrome complex assembly (GO:0017004)2.80720502
82positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.80532308
83positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.80454327
84modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79645168
85modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79645168
86positive regulation by organism of defense response of other organism involved in symbiotic interact2.79645168
87modulation by symbiont of host immune response (GO:0052553)2.79645168
88positive regulation by symbiont of host defense response (GO:0052509)2.79645168
89modulation by symbiont of host defense response (GO:0052031)2.79645168
90recombinational repair (GO:0000725)2.79539324
91synapsis (GO:0007129)2.79180960
92tryptophan metabolic process (GO:0006568)2.78450915
93regulation of interferon-beta biosynthetic process (GO:0045357)2.78149841
94leukocyte aggregation (GO:0070486)2.77637678
95double-strand break repair via homologous recombination (GO:0000724)2.76021602
96mitochondrial RNA metabolic process (GO:0000959)2.75546121
97natural killer cell mediated immunity (GO:0002228)2.75381111
98natural killer cell mediated cytotoxicity (GO:0042267)2.75381111
99reactive oxygen species biosynthetic process (GO:1903409)2.74877100
100protein deneddylation (GO:0000338)2.74839281
101regulation of RIG-I signaling pathway (GO:0039535)2.74512522
102magnesium ion transport (GO:0015693)2.74005017
103lipopolysaccharide-mediated signaling pathway (GO:0031663)2.72843471
104hydrogen peroxide biosynthetic process (GO:0050665)2.72225177
105regulation of acyl-CoA biosynthetic process (GO:0050812)2.71813347
106prenylation (GO:0097354)2.69830252
107protein prenylation (GO:0018342)2.69830252
108cellular response to interferon-beta (GO:0035458)2.69107368
109indolalkylamine metabolic process (GO:0006586)2.69068660
110positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67748758
111detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66602851
112positive regulation of B cell differentiation (GO:0045579)2.66543745
113cellular response to exogenous dsRNA (GO:0071360)2.66524262
114antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.66090148
115nonmotile primary cilium assembly (GO:0035058)2.65691652
116S-adenosylmethionine metabolic process (GO:0046500)2.65625868
117water-soluble vitamin biosynthetic process (GO:0042364)2.64662097
118negative regulation of myeloid cell apoptotic process (GO:0033033)2.59924208
119establishment of protein localization to mitochondrial membrane (GO:0090151)2.59625642
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59087174
121somatic hypermutation of immunoglobulin genes (GO:0016446)2.58614763
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.58614763
123cilium morphogenesis (GO:0060271)2.57948602
124DNA catabolic process, exonucleolytic (GO:0000738)2.56531276
125antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.56405845
126tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56366345
127RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56366345
128ribosome assembly (GO:0042255)2.55310631
129photoreceptor cell maintenance (GO:0045494)2.54905041
130regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54601336
131antigen processing and presentation via MHC class Ib (GO:0002475)2.54382060
132mannosylation (GO:0097502)2.53181447
133transcription elongation from RNA polymerase III promoter (GO:0006385)2.52926612
134termination of RNA polymerase III transcription (GO:0006386)2.52926612
135negative regulation of DNA recombination (GO:0045910)2.50046123
136preassembly of GPI anchor in ER membrane (GO:0016254)2.49727518
137L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.49046274
138establishment of protein localization to Golgi (GO:0072600)2.48908114
139rRNA catabolic process (GO:0016075)2.48672374
140ketone body metabolic process (GO:1902224)2.47831929
141signal peptide processing (GO:0006465)2.47789614
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.47427634
143intraciliary transport (GO:0042073)2.46231946
144mitotic cell cycle arrest (GO:0071850)2.45574246
145regulation of mesoderm development (GO:2000380)2.45429009
146behavioral response to nicotine (GO:0035095)2.44476506
147resolution of meiotic recombination intermediates (GO:0000712)2.43554959
148cellular response to type I interferon (GO:0071357)2.42788876
149type I interferon signaling pathway (GO:0060337)2.42788876
150regulation of B cell differentiation (GO:0045577)2.38561719
151leukocyte mediated cytotoxicity (GO:0001909)2.38459551
152response to type I interferon (GO:0034340)2.38451498
153negative regulation of viral genome replication (GO:0045071)2.36920505
154regulation of interferon-beta production (GO:0032648)2.36364374
155regulation of vitamin D biosynthetic process (GO:0060556)2.36036565
156regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.34372947
157endosome to melanosome transport (GO:0035646)2.33750304
158endosome to pigment granule transport (GO:0043485)2.33750304
159regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.33571556
160defense response to protozoan (GO:0042832)2.31364311
161positive regulation of type I interferon production (GO:0032481)2.28275976
162negative regulation of growth of symbiont in host (GO:0044130)2.28231916
163negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.28231916
164modulation of growth of symbiont involved in interaction with host (GO:0044144)2.28231916
165regulation of growth of symbiont in host (GO:0044126)2.28231916
166formation of translation preinitiation complex (GO:0001731)2.27409540
167neutrophil activation (GO:0042119)2.27402961
168regulation of necroptotic process (GO:0060544)2.27267280
169granulocyte activation (GO:0036230)2.26515035
170regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.25748403
171DNA strand elongation involved in DNA replication (GO:0006271)2.25725664
172regulation of interleukin-12 biosynthetic process (GO:0045075)2.25669870
173response to interferon-alpha (GO:0035455)2.25649938
174myeloid dendritic cell activation (GO:0001773)2.24482269
175interferon-gamma-mediated signaling pathway (GO:0060333)2.24388900
176positive regulation of protein import into nucleus, translocation (GO:0033160)2.24094170
177detection of molecule of bacterial origin (GO:0032490)2.23721748
178telomere maintenance via semi-conservative replication (GO:0032201)2.22564079
179antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.22242001
180regulation of response to interferon-gamma (GO:0060330)2.19881826
181response to muramyl dipeptide (GO:0032495)2.19630681
182positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.19297363
183macrophage activation involved in immune response (GO:0002281)2.19038990
184response to protozoan (GO:0001562)2.18889929
185superoxide anion generation (GO:0042554)2.18505752
186negative regulation of interleukin-12 production (GO:0032695)2.17921797
187cellular response to dsRNA (GO:0071359)2.17873111
188cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.17271052
189telomere maintenance via recombination (GO:0000722)2.15858557
190myeloid dendritic cell differentiation (GO:0043011)2.15809272
191necroptotic process (GO:0070266)2.14694910
192positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.14094620
193regulation of type I interferon-mediated signaling pathway (GO:0060338)2.13827168
194positive regulation of tumor necrosis factor production (GO:0032760)2.13254541
195deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.12651488
196regulation of T-helper 1 cell differentiation (GO:0045625)2.12308444
197DNA strand elongation (GO:0022616)2.12307937
198positive regulation of cytokine biosynthetic process (GO:0042108)2.11523151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.78336051
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.25409287
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.70868832
4ZNF274_21170338_ChIP-Seq_K562_Hela3.34506479
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.31176914
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.14676871
7VDR_22108803_ChIP-Seq_LS180_Human2.71101217
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70378195
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69998856
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.59579235
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.57269144
12EWS_26573619_Chip-Seq_HEK293_Human2.55095042
13FUS_26573619_Chip-Seq_HEK293_Human2.49054696
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.48159248
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.43254247
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40372046
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39205090
18TAF15_26573619_Chip-Seq_HEK293_Human2.37133435
19IGF1R_20145208_ChIP-Seq_DFB_Human2.34936033
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27950779
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26985959
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26954087
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.18665157
24GBX2_23144817_ChIP-Seq_PC3_Human2.17355475
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17279071
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15759713
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.15190537
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08538426
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05044257
30P300_19829295_ChIP-Seq_ESCs_Human2.05017610
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04300906
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03982990
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.02172587
34IRF8_27001747_Chip-Seq_BMDM_Mouse2.01982589
35PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00071669
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99920196
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98697813
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95290800
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95038029
40* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93079170
41SPI1_23547873_ChIP-Seq_NB4_Human1.90253676
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90083436
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.88948247
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88183532
45VDR_23849224_ChIP-Seq_CD4+_Human1.86905995
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86017043
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85974166
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83729949
49* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79839095
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70067137
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69297658
52* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69278417
53ER_23166858_ChIP-Seq_MCF-7_Human1.68988868
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67575339
55ELK1_19687146_ChIP-ChIP_HELA_Human1.66885524
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66123620
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65510165
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.64743940
59MYC_18940864_ChIP-ChIP_HL60_Human1.64637011
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62127655
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60941890
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.60797795
63* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60642147
64* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60420870
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59826663
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57556651
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56838834
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.55450559
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55377310
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55106760
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.53296912
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52835054
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52739295
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52129177
75MYB_26560356_Chip-Seq_TH2_Human1.50044569
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49559014
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49521173
78FOXP3_21729870_ChIP-Seq_TREG_Human1.48600451
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.48396341
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47898974
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46642007
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.45713131
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45621111
84DCP1A_22483619_ChIP-Seq_HELA_Human1.45436452
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42641482
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42340049
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41875082
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41002058
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40974888
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37008009
91MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36206131
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35847978
93IRF1_19129219_ChIP-ChIP_H3396_Human1.35790315
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.34706697
95SCL_19346495_ChIP-Seq_HPC-7_Human1.34508852
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33546062
97CBP_20019798_ChIP-Seq_JUKART_Human1.33546062
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32850255
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.32346330
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31118196
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31074393
102* XRN2_22483619_ChIP-Seq_HELA_Human1.30679515
103CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30549739
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30503646
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29146853
106MYC_22102868_ChIP-Seq_BL_Human1.28406524
107GABP_19822575_ChIP-Seq_HepG2_Human1.25417289
108TP53_22573176_ChIP-Seq_HFKS_Human1.24740581
109NANOG_19829295_ChIP-Seq_ESCs_Human1.24420159
110SOX2_19829295_ChIP-Seq_ESCs_Human1.24420159
111MYB_26560356_Chip-Seq_TH1_Human1.23180478
112GATA1_22025678_ChIP-Seq_K562_Human1.23124733
113RUNX1_22412390_ChIP-Seq_EML_Mouse1.22975591
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21972446
115ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21562542
116TFEB_21752829_ChIP-Seq_HELA_Human1.21510427
117SMAD4_21799915_ChIP-Seq_A2780_Human1.19935965
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19870582
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19861838
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19302286
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.18550739
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18547919
123AR_25329375_ChIP-Seq_VCAP_Human1.17379728
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17230098
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15849459
126HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15236316
127GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14850604
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14808648
129STAT3_23295773_ChIP-Seq_U87_Human1.14305414
130FOXA1_25329375_ChIP-Seq_VCAP_Human1.14196229
131FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14196229
132* TCF4_22108803_ChIP-Seq_LS180_Human1.13568459
133E2F1_21310950_ChIP-Seq_MCF-7_Human1.12307367
134CDX2_22108803_ChIP-Seq_LS180_Human1.11807256
135SMAD3_21741376_ChIP-Seq_EPCs_Human1.10427996
136NANOG_18555785_Chip-Seq_ESCs_Mouse1.09695787
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09652400
138VDR_24763502_ChIP-Seq_THP-1_Human1.09344925
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08993052
140AR_21909140_ChIP-Seq_LNCAP_Human1.08748622
141TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08199058
142KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07532469
143HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06984312
144MAF_26560356_Chip-Seq_TH1_Human1.06517680
145NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06388522
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05945365
147KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05739336
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05629588
149BCAT_22108803_ChIP-Seq_LS180_Human1.04425191
150PU_27001747_Chip-Seq_BMDM_Mouse1.02422958
151FLI1_21867929_ChIP-Seq_TH2_Mouse1.02079003
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01681967
153EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01564252
154VDR_21846776_ChIP-Seq_THP-1_Human1.01077860
155NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01058198
156GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99816252
157CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99234372
158CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99203390
159* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99174181
160SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99060704
161AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98847338
162SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98795786
163AR_20517297_ChIP-Seq_VCAP_Human0.98715898
164MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98567314
165E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98538178
166P53_22387025_ChIP-Seq_ESCs_Mouse0.98517938
167STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98473013
168OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98047470
169MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97830459
170SMAD4_21741376_ChIP-Seq_EPCs_Human0.97549859
171LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97410796
172* NANOG_16153702_ChIP-ChIP_HESCs_Human0.97330985
173HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96584824
174FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96006264
175RUNX2_22187159_ChIP-Seq_PCA_Human0.95272335
176SOX2_16153702_ChIP-ChIP_HESCs_Human0.94825424
177TCF4_23295773_ChIP-Seq_U87_Human0.94172680
178SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93609726
179JUN_21703547_ChIP-Seq_K562_Human0.92951678
180TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92241184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.91304072
2MP0009785_altered_susceptibility_to3.34688313
3MP0003436_decreased_susceptibility_to3.12088233
4MP0008877_abnormal_DNA_methylation3.07915033
5MP0002102_abnormal_ear_morphology2.91127352
6MP0002254_reproductive_system_inflammat2.84457840
7MP0002148_abnormal_hypersensitivity_rea2.62724700
8MP0005084_abnormal_gallbladder_morpholo2.61820920
9MP0003724_increased_susceptibility_to2.59566192
10MP0005000_abnormal_immune_tolerance2.56443988
11MP0005025_abnormal_response_to2.55049794
12MP0002419_abnormal_innate_immunity2.51243988
13MP0005671_abnormal_response_to2.50170476
14MP0006072_abnormal_retinal_apoptosis2.46597027
15MP0000569_abnormal_digit_pigmentation2.29253860
16MP0002452_abnormal_antigen_presenting2.26668762
17MP0006082_CNS_inflammation2.22736671
18MP0000685_abnormal_immune_system2.18117532
19MP0001800_abnormal_humoral_immune2.15578180
20MP0002723_abnormal_immune_serum2.14594198
21MP0003186_abnormal_redox_activity2.12489541
22MP0002938_white_spotting2.08643620
23MP0003693_abnormal_embryo_hatching2.08424130
24MP0001853_heart_inflammation2.07461867
25MP0009333_abnormal_splenocyte_physiolog2.04864897
26MP0001819_abnormal_immune_cell2.00151547
27MP0002420_abnormal_adaptive_immunity1.99599034
28MP0002006_tumorigenesis1.98082571
29MP0005551_abnormal_eye_electrophysiolog1.94507216
30MP0005253_abnormal_eye_physiology1.91275031
31MP0003763_abnormal_thymus_physiology1.88180870
32MP0004147_increased_porphyrin_level1.87341361
33MP0001545_abnormal_hematopoietic_system1.82158970
34MP0005397_hematopoietic_system_phenotyp1.82158970
35MP0002405_respiratory_system_inflammati1.81102415
36MP0001790_abnormal_immune_system1.80585635
37MP0005387_immune_system_phenotype1.80585635
38MP0005464_abnormal_platelet_physiology1.80012579
39MP0003890_abnormal_embryonic-extraembry1.75760023
40MP0001293_anophthalmia1.75468679
41MP0001845_abnormal_inflammatory_respons1.73464646
42MP0008875_abnormal_xenobiotic_pharmacok1.72866590
43MP0000427_abnormal_hair_cycle1.72745391
44MP0002837_dystrophic_cardiac_calcinosis1.70861028
45MP0003567_abnormal_fetal_cardiomyocyte1.70203786
46MP0000858_altered_metastatic_potential1.68920760
47MP0005367_renal/urinary_system_phenotyp1.68889861
48MP0000516_abnormal_urinary_system1.68889861
49MP0002398_abnormal_bone_marrow1.68191092
50MP0005410_abnormal_fertilization1.66350807
51MP0004133_heterotaxia1.65080017
52MP0002138_abnormal_hepatobiliary_system1.64242348
53MP0001529_abnormal_vocalization1.63093380
54MP0009764_decreased_sensitivity_to1.60896097
55MP0001533_abnormal_skeleton_physiology1.60452375
56MP0000716_abnormal_immune_system1.60267124
57MP0010155_abnormal_intestine_physiology1.59415896
58MP0000647_abnormal_sebaceous_gland1.59037371
59MP0004947_skin_inflammation1.57804325
60MP0006292_abnormal_olfactory_placode1.55589372
61MP0000689_abnormal_spleen_morphology1.53500754
62MP0008469_abnormal_protein_level1.53458880
63MP0005187_abnormal_penis_morphology1.53177514
64MP0010386_abnormal_urinary_bladder1.45121319
65MP0002396_abnormal_hematopoietic_system1.44323072
66MP0002429_abnormal_blood_cell1.44018750
67MP0003806_abnormal_nucleotide_metabolis1.42922935
68MP0002722_abnormal_immune_system1.42705511
69MP0003448_altered_tumor_morphology1.42453122
70MP0010094_abnormal_chromosome_stability1.41302641
71MP0008057_abnormal_DNA_replication1.41024402
72MP0003077_abnormal_cell_cycle1.39766429
73MP0002166_altered_tumor_susceptibility1.37711377
74MP0008007_abnormal_cellular_replicative1.37135229
75MP0000490_abnormal_crypts_of1.36571064
76MP0002009_preneoplasia1.35803791
77MP0002132_abnormal_respiratory_system1.35386571
78MP0000343_altered_response_to1.34959537
79MP0005058_abnormal_lysosome_morphology1.34626969
80MP0003303_peritoneal_inflammation1.34033604
81MP0000383_abnormal_hair_follicle1.33060367
82MP0001984_abnormal_olfaction1.32896624
83MP0005389_reproductive_system_phenotype1.31249469
84MP0004957_abnormal_blastocyst_morpholog1.30586369
85MP0004808_abnormal_hematopoietic_stem1.30388846
86MP0003937_abnormal_limbs/digits/tail_de1.29707884
87MP0008058_abnormal_DNA_repair1.29557387
88MP0003136_yellow_coat_color1.29024360
89MP0001485_abnormal_pinna_reflex1.28250782
90MP0010352_gastrointestinal_tract_polyps1.27914835
91MP0002653_abnormal_ependyma_morphology1.27842723
92MP0003191_abnormal_cellular_cholesterol1.26791009
93MP0001929_abnormal_gametogenesis1.25774916
94MP0003941_abnormal_skin_development1.24492328
95MP0004142_abnormal_muscle_tone1.24248485
96MP0002234_abnormal_pharynx_morphology1.24136322
97MP0004782_abnormal_surfactant_physiolog1.20437025
98MP0003119_abnormal_digestive_system1.19560723
99MP0009840_abnormal_foam_cell1.19287606
100MP0001919_abnormal_reproductive_system1.18298829
101MP0005451_abnormal_body_composition1.17225772
102MP0003656_abnormal_erythrocyte_physiolo1.16224021
103MP0010307_abnormal_tumor_latency1.13800616
104MP0003950_abnormal_plasma_membrane1.13425740
105MP0008872_abnormal_physiological_respon1.13051186
106MP0004043_abnormal_pH_regulation1.12909663
107MP0006054_spinal_hemorrhage1.12224569
108MP0000372_irregular_coat_pigmentation1.10392641
109MP0002019_abnormal_tumor_incidence1.10208270
110MP0009278_abnormal_bone_marrow1.10024388
111MP0001873_stomach_inflammation1.08468041
112MP0005379_endocrine/exocrine_gland_phen1.07275350
113MP0009697_abnormal_copulation1.06847073
114MP0003787_abnormal_imprinting1.06409905
115MP0002277_abnormal_respiratory_mucosa1.05612244
116MP0003786_premature_aging1.04221607
117MP0000653_abnormal_sex_gland1.03822917
118MP0000631_abnormal_neuroendocrine_gland1.02068962
119MP0002210_abnormal_sex_determination1.01393057
120MP0002751_abnormal_autonomic_nervous1.00909254
121MP0009763_increased_sensitivity_to1.00111751
122MP0002139_abnormal_hepatobiliary_system0.99408099
123MP0003011_delayed_dark_adaptation0.98949051
124MP0005332_abnormal_amino_acid0.97465316
125MP0003698_abnormal_male_reproductive0.96127418
126MP0002736_abnormal_nociception_after0.95875859
127MP0002933_joint_inflammation0.94986057
128MP0008789_abnormal_olfactory_epithelium0.94239571
129MP0004215_abnormal_myocardial_fiber0.94011884
130MP0001145_abnormal_male_reproductive0.92981545
131MP0001324_abnormal_eye_pigmentation0.92277726
132MP0003111_abnormal_nucleus_morphology0.91921892
133MP0002160_abnormal_reproductive_system0.91615791
134MP0005085_abnormal_gallbladder_physiolo0.91271348
135MP0001286_abnormal_eye_development0.91070751
136MP0006276_abnormal_autonomic_nervous0.90920625
137MP0005391_vision/eye_phenotype0.90392282
138MP0005390_skeleton_phenotype0.90176711
139MP0002998_abnormal_bone_remodeling0.90141570
140MP0006035_abnormal_mitochondrial_morpho0.89981540
141MP0008260_abnormal_autophagy0.89340212
142MP0000465_gastrointestinal_hemorrhage0.89180871
143MP0008932_abnormal_embryonic_tissue0.88247204
144MP0000703_abnormal_thymus_morphology0.87993124
145MP0002090_abnormal_vision0.86410255
146MP0005195_abnormal_posterior_eye0.85500148
147MP0005395_other_phenotype0.84664967
148MP0002163_abnormal_gland_morphology0.84549003
149MP0005408_hypopigmentation0.83852127
150MP0005023_abnormal_wound_healing0.83317609
151MP0002876_abnormal_thyroid_physiology0.81816055
152MP0008995_early_reproductive_senescence0.81479488
153MP0003315_abnormal_perineum_morphology0.81294919
154MP0005166_decreased_susceptibility_to0.81250381
155MP0005164_abnormal_response_to0.80370045
156MP0010678_abnormal_skin_adnexa0.79839159
157MP0003121_genomic_imprinting0.79720572
158MP0000613_abnormal_salivary_gland0.79079185
159MP0002928_abnormal_bile_duct0.78893824
160MP0001501_abnormal_sleep_pattern0.78213548
161MP0009046_muscle_twitch0.78012056
162MP0002233_abnormal_nose_morphology0.76949526
163MP0000609_abnormal_liver_physiology0.75436975
164MP0005319_abnormal_enzyme/_coenzyme0.74700246
165MP0000598_abnormal_liver_morphology0.73953969
166MP0003195_calcinosis0.73346623
167MP0001243_abnormal_dermal_layer0.72864778
168MP0003828_pulmonary_edema0.72237344
169MP0003795_abnormal_bone_structure0.70655604
170MP0001119_abnormal_female_reproductive0.70545670
171MP0005174_abnormal_tail_pigmentation0.69209056
172MP0000313_abnormal_cell_death0.68924059
173MP0003075_altered_response_to0.67475726
174MP0003718_maternal_effect0.67449153
175MP0003453_abnormal_keratinocyte_physiol0.66465457
176MP0001764_abnormal_homeostasis0.66380672
177MP0000371_diluted_coat_color0.66113518
178MP0001851_eye_inflammation0.65741594
179MP0005075_abnormal_melanosome_morpholog0.65721192
180MP0000350_abnormal_cell_proliferation0.65248101
181MP0008873_increased_physiological_sensi0.64287907

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.14108321
2Eczematoid dermatitis (HP:0000976)4.70788063
3Recurrent bacterial skin infections (HP:0005406)4.70636346
4Recurrent gram-negative bacterial infections (HP:0005420)4.49833078
5Elevated erythrocyte sedimentation rate (HP:0003565)4.43041225
6Pancreatic cysts (HP:0001737)4.08740625
7Mediastinal lymphadenopathy (HP:0100721)3.89191756
8Myositis (HP:0100614)3.82418052
9True hermaphroditism (HP:0010459)3.81252309
10Pancreatic fibrosis (HP:0100732)3.56003595
11Autoimmune thrombocytopenia (HP:0001973)3.51859723
12Abnormality of macrophages (HP:0004311)3.40720809
13Molar tooth sign on MRI (HP:0002419)3.29850542
14Abnormality of midbrain morphology (HP:0002418)3.29850542
15Stomatitis (HP:0010280)3.25811376
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.24483992
17Abnormality of alanine metabolism (HP:0010916)3.24483992
18Hyperalaninemia (HP:0003348)3.24483992
19Orchitis (HP:0100796)3.22025948
20Recurrent skin infections (HP:0001581)3.17260302
21Recurrent viral infections (HP:0004429)3.16915367
22Poor head control (HP:0002421)3.15227002
23Thrombocytosis (HP:0001894)3.12244078
24Retrobulbar optic neuritis (HP:0100654)3.09777632
25Optic neuritis (HP:0100653)3.09777632
26Pustule (HP:0200039)3.07880045
27Recurrent fungal infections (HP:0002841)3.00675311
28Congenital stationary night blindness (HP:0007642)2.98396785
29Petechiae (HP:0000967)2.95836180
30Vacuolated lymphocytes (HP:0001922)2.90097734
31Attenuation of retinal blood vessels (HP:0007843)2.84166430
32Medial flaring of the eyebrow (HP:0010747)2.82461823
33Abnormality of the renal cortex (HP:0011035)2.79241017
34Chronic hepatic failure (HP:0100626)2.74641080
35Vasculitis (HP:0002633)2.70669314
36Agnosia (HP:0010524)2.69433711
37Nephronophthisis (HP:0000090)2.66734633
38Abolished electroretinogram (ERG) (HP:0000550)2.63966954
39Periodontitis (HP:0000704)2.62559745
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.61238941
41Aplastic anemia (HP:0001915)2.60342585
42Nausea (HP:0002018)2.57756561
43Renal cortical cysts (HP:0000803)2.49038097
44Methylmalonic acidemia (HP:0002912)2.48746071
45Progressive inability to walk (HP:0002505)2.44187832
46Inability to walk (HP:0002540)2.40689447
47Abnormality of T cell physiology (HP:0011840)2.40149076
48Congenital primary aphakia (HP:0007707)2.39484535
49Increased IgM level (HP:0003496)2.38607977
50Abnormality of T cells (HP:0002843)2.37640497
51Neuroendocrine neoplasm (HP:0100634)2.37128102
52Chronic obstructive pulmonary disease (HP:0006510)2.36967832
53Obstructive lung disease (HP:0006536)2.36967832
54Chronic mucocutaneous candidiasis (HP:0002728)2.35938245
55Recurrent cutaneous fungal infections (HP:0011370)2.35938245
56Basal ganglia calcification (HP:0002135)2.35348699
57IgM deficiency (HP:0002850)2.34861930
58Abnormality of the renal medulla (HP:0100957)2.34834419
59Abnormality of serum amino acid levels (HP:0003112)2.34678988
60Gingivitis (HP:0000230)2.34330761
61Reduced antithrombin III activity (HP:0001976)2.33932307
62Meningitis (HP:0001287)2.33683526
63Colon cancer (HP:0003003)2.32789735
64Congenital, generalized hypertrichosis (HP:0004540)2.32279843
65Leukocytosis (HP:0001974)2.31576078
66Pulmonary infiltrates (HP:0002113)2.31011539
67Hypergammaglobulinemia (HP:0010702)2.28836662
68Increased CSF lactate (HP:0002490)2.27993094
69Recurrent bronchitis (HP:0002837)2.27886290
70Lipid accumulation in hepatocytes (HP:0006561)2.27750308
71Acute encephalopathy (HP:0006846)2.27554200
72Cellulitis (HP:0100658)2.27500524
73Intestinal atresia (HP:0011100)2.27411222
74Pheochromocytoma (HP:0002666)2.24874170
75Acute necrotizing encephalopathy (HP:0006965)2.24059176
76Chronic otitis media (HP:0000389)2.21623705
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21585193
78Combined immunodeficiency (HP:0005387)2.20688527
79Systemic lupus erythematosus (HP:0002725)2.20520540
80Gait imbalance (HP:0002141)2.19365319
81Abnormal protein glycosylation (HP:0012346)2.19280066
82Abnormal glycosylation (HP:0012345)2.19280066
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19280066
84Abnormal protein N-linked glycosylation (HP:0012347)2.19280066
85Abnormality of T cell number (HP:0011839)2.18063827
86Genital tract atresia (HP:0001827)2.17328920
87Urticaria (HP:0001025)2.17129059
88Nephrogenic diabetes insipidus (HP:0009806)2.16388666
89Abnormality of the prostate (HP:0008775)2.16313219
90Interstitial pulmonary disease (HP:0006530)2.16190566
91Abnormal rod and cone electroretinograms (HP:0008323)2.15545130
92Short tibia (HP:0005736)2.15496650
93Recurrent pneumonia (HP:0006532)2.14939480
94Furrowed tongue (HP:0000221)2.14136229
95Purpura (HP:0000979)2.12336294
96T lymphocytopenia (HP:0005403)2.12117347
97Vaginal atresia (HP:0000148)2.11925352
98Increased hepatocellular lipid droplets (HP:0006565)2.11853165
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.11588929
100Methylmalonic aciduria (HP:0012120)2.11030952
101Hyperglycinemia (HP:0002154)2.10518688
102Aplasia/Hypoplasia of the tongue (HP:0010295)2.10024174
103Hyperglycinuria (HP:0003108)2.09231423
104Meckel diverticulum (HP:0002245)2.09066712
105Abnormality of the labia minora (HP:0012880)2.07521742
106Birth length less than 3rd percentile (HP:0003561)2.07127788
107Male pseudohermaphroditism (HP:0000037)2.05148539
108Abnormal number of erythroid precursors (HP:0012131)2.04948743
109Mitochondrial inheritance (HP:0001427)2.04770864
110Abnormality of cells of the erythroid lineage (HP:0012130)2.04267584
111Congenital sensorineural hearing impairment (HP:0008527)2.03918874
112Pendular nystagmus (HP:0012043)2.03205611
113Recurrent lower respiratory tract infections (HP:0002783)2.02814483
114Abnormality of the ileum (HP:0001549)2.02192218
115Type II lissencephaly (HP:0007260)2.01813864
116Keratoconjunctivitis sicca (HP:0001097)2.01253403
117Arterial thrombosis (HP:0004420)2.01112356
118Abnormality of methionine metabolism (HP:0010901)2.00524831
119Generalized aminoaciduria (HP:0002909)2.00417129
120Aplasia/Hypoplasia of the uvula (HP:0010293)2.00345990
121Type I transferrin isoform profile (HP:0003642)2.00033759
122Epistaxis (HP:0000421)1.99649007
123Vertebral compression fractures (HP:0002953)1.98224202
124Abnormal biliary tract physiology (HP:0012439)1.97673486
125Bile duct proliferation (HP:0001408)1.97673486
126Optic nerve hypoplasia (HP:0000609)1.96328961
127Gingival bleeding (HP:0000225)1.96299800
128Abnormality of the pons (HP:0007361)1.96273732
129Aplasia/hypoplasia of the uterus (HP:0008684)1.95809626
130Hypothermia (HP:0002045)1.95656779
131Sclerocornea (HP:0000647)1.95386680
132Progressive macrocephaly (HP:0004481)1.94951284
133Abnormal lung lobation (HP:0002101)1.94793458
134Stomach cancer (HP:0012126)1.94334236
135IgG deficiency (HP:0004315)1.93861918
136Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93841849
137Anencephaly (HP:0002323)1.93553774
138Prostate neoplasm (HP:0100787)1.93135892
139Osteomyelitis (HP:0002754)1.91869625
140Lymphoma (HP:0002665)1.90877156
141Hypoplasia of the fovea (HP:0007750)1.90135703
142Aplasia/Hypoplasia of the fovea (HP:0008060)1.90135703
143Cystic liver disease (HP:0006706)1.89831511
144Joint swelling (HP:0001386)1.88135551
145Increased neuronal autofluorescent lipopigment (HP:0002074)1.87962181
146Gastrointestinal infarctions (HP:0005244)1.87892542
147Lymphopenia (HP:0001888)1.87861789
148Abnormality of cells of the lymphoid lineage (HP:0012140)1.87680607
149Hemoptysis (HP:0002105)1.85912917
150Palpitations (HP:0001962)1.85206335
151Anorexia (HP:0002039)1.85012445
152Decreased central vision (HP:0007663)1.84886690
153Sloping forehead (HP:0000340)1.84367907
154Gangrene (HP:0100758)1.83794793
155Postaxial foot polydactyly (HP:0001830)1.83544100
156Stenosis of the external auditory canal (HP:0000402)1.83336724
157Pancreatic islet-cell hyperplasia (HP:0004510)1.82558583
158Amaurosis fugax (HP:0100576)1.82159842
159Autoimmune hemolytic anemia (HP:0001890)1.81770292
160Tetraparesis (HP:0002273)1.81578439
161Severe combined immunodeficiency (HP:0004430)1.81267216
162Abnormality of glycine metabolism (HP:0010895)1.81263945
163Abnormality of serine family amino acid metabolism (HP:0010894)1.81263945
164Multiple enchondromatosis (HP:0005701)1.80827252
165Neutropenia (HP:0001875)1.80807383
166Large for gestational age (HP:0001520)1.80801810
167Keratoconjunctivitis (HP:0001096)1.80796378
168Median cleft lip (HP:0000161)1.78833525
169Encephalitis (HP:0002383)1.78541863
170Abnormality of sulfur amino acid metabolism (HP:0004339)1.78403971
171Hepatosplenomegaly (HP:0001433)1.78347953
172Thrombophlebitis (HP:0004418)1.78085564
173Congenital hepatic fibrosis (HP:0002612)1.78023831
174Postaxial hand polydactyly (HP:0001162)1.77598790
175Abnormality of macular pigmentation (HP:0008002)1.76900365
176Microcytic anemia (HP:0001935)1.76804971
177Neoplasm of the adrenal gland (HP:0100631)1.75058868
178Granulocytopenia (HP:0001913)1.74624108
179Skin ulcer (HP:0200042)1.74426569
180Abnormality of vitamin B metabolism (HP:0004340)1.74037966
181Polydipsia (HP:0001959)1.73644343
182Abnormal drinking behavior (HP:0030082)1.73644343
183Abnormality of the fovea (HP:0000493)1.73618456
184Tubular atrophy (HP:0000092)1.73142774
185Dandy-Walker malformation (HP:0001305)1.73110829
186Poor coordination (HP:0002370)1.73020268
187Myocardial infarction (HP:0001658)1.72819139
188Joint hemorrhage (HP:0005261)1.72207280
189Preaxial hand polydactyly (HP:0001177)1.71544861
190Exertional dyspnea (HP:0002875)1.70918655
191Spontaneous hematomas (HP:0007420)1.70418166
192Pallor (HP:0000980)1.69665287
193Abnormality of eosinophils (HP:0001879)1.68502040
194Eosinophilia (HP:0001880)1.68120048
195Prolonged bleeding time (HP:0003010)1.67591347
196Reticulocytopenia (HP:0001896)1.67339051
197Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.66618622
198Pulmonary fibrosis (HP:0002206)1.64475759

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.21931253
2PBK3.28407355
3MAP4K12.94962149
4TRIM282.79881102
5BLK2.76259286
6WNK32.68430528
7TBK12.66009300
8NME22.59801505
9MAP4K22.59434421
10IKBKE2.42131334
11MAP3K142.41151656
12TXK2.39031573
13TYK22.22908573
14JAK32.20246199
15MKNK12.09661351
16MKNK22.08126087
17PIM22.05150841
18IRAK32.04118806
19TNIK2.02527527
20ADRBK21.99506311
21RPS6KA41.97650017
22STK38L1.97103988
23VRK21.95868073
24BCR1.88475700
25KIT1.86840451
26EIF2AK31.86680027
27IRAK41.85883257
28EIF2AK11.75366532
29IKBKB1.70732837
30ZAP701.68646419
31PLK31.68237129
32GRK11.66924756
33TEC1.58600486
34NEK91.57892047
35TSSK61.53504418
36RIPK41.52787694
37BUB11.49229840
38INSRR1.47024019
39ERN11.44168856
40TGFBR11.43965467
41ACVR1B1.42499774
42STK101.41287415
43PIM11.39750705
44MST41.36449841
45KDR1.35525946
46WEE11.34424219
47MAP3K41.31207578
48WNK41.29494049
49BTK1.27541482
50OXSR11.27424454
51NEK21.25372180
52CDC71.21342124
53BRSK21.19303512
54STK161.18656781
55PLK41.16317933
56NEK11.13905577
57PLK21.13738267
58AKT31.12574811
59CHUK1.11298191
60EEF2K1.11129727
61DYRK31.08322029
62FLT31.06812375
63TESK11.05057241
64SRPK11.03161816
65PINK11.02446423
66STK41.02137504
67STK390.99833039
68CSF1R0.99172123
69MAP3K110.99023304
70MAP3K130.97553692
71TAF10.97337699
72LYN0.96423161
73MST1R0.94658242
74TGFBR20.94158240
75CSNK1G10.93451845
76VRK10.92672406
77SCYL20.92437483
78LRRK20.92079580
79TAOK30.91884772
80TLK10.90540569
81MAPK130.90122939
82SYK0.89795816
83TESK20.88362157
84CASK0.86796541
85EIF2AK20.85774850
86TTK0.85231002
87TAOK20.84847124
88ABL20.84618994
89YES10.83455477
90PAK30.82811714
91CSNK1G20.81417966
92RAF10.81046266
93JAK10.80755111
94CSNK1G30.80067782
95LCK0.79969565
96NLK0.79789484
97MAP3K30.79575865
98TRPM70.78600358
99NUAK10.76900484
100PRKCE0.76513607
101CSNK1A1L0.76092449
102RPS6KB20.74028074
103TIE10.73717693
104ATR0.72969985
105MAP3K80.71754354
106MAP2K30.70383863
107PASK0.67689587
108ARAF0.67387690
109MAP2K70.66717064
110AURKB0.66395387
111ITK0.65103214
112PLK10.64498799
113LATS10.63026855
114JAK20.62848898
115MARK30.62833946
116STK240.62332936
117SIK30.60680645
118CDK70.60283473
119CDK40.59779031
120FER0.59233599
121MAPKAPK30.58505702
122MAP3K50.57447161
123EPHA30.56663760
124BCKDK0.56514154
125ADRBK10.55411638
126IRAK10.55274969
127FGFR40.55105800
128MAPKAPK50.54738344
129DYRK20.54517116
130ERBB40.54158266
131CSK0.52506530
132MOS0.52487079
133BRD40.51785484
134PDK20.49455373
135GRK70.47755685
136ZAK0.47430422
137ERBB30.47407889
138PNCK0.46927686
139DAPK20.45711482
140BMPR1B0.44603253
141MATK0.44196783
142RPS6KA50.44058552
143CDK80.43757471
144STK30.43598753
145HCK0.43270822
146MELK0.43210317
147BMPR20.42640301
148CHEK20.41816822
149MUSK0.39734168
150PRKCD0.39502808
151CSNK1A10.30563009
152LIMK10.29023760
153ATM0.29000929
154CSNK2A10.28998865
155PRKCG0.28610437
156NME10.26983824
157IGF1R0.26800120
158CAMKK20.24804037
159PTK2B0.23620884
160PIK3CA0.23354706

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.94700753
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78053414
3Graft-versus-host disease_Homo sapiens_hsa053322.60374169
4DNA replication_Homo sapiens_hsa030302.56351425
5Legionellosis_Homo sapiens_hsa051342.45042337
6Proteasome_Homo sapiens_hsa030502.42708793
7Leishmaniasis_Homo sapiens_hsa051402.33384494
8Propanoate metabolism_Homo sapiens_hsa006402.24277093
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.14401771
10Oxidative phosphorylation_Homo sapiens_hsa001902.13124654
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02879686
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94349326
13Butanoate metabolism_Homo sapiens_hsa006501.90891926
14Ribosome_Homo sapiens_hsa030101.88840220
15Measles_Homo sapiens_hsa051621.85184741
16Staphylococcus aureus infection_Homo sapiens_hsa051501.82574479
17Malaria_Homo sapiens_hsa051441.80287936
18Base excision repair_Homo sapiens_hsa034101.77896821
19Antigen processing and presentation_Homo sapiens_hsa046121.77604596
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75709500
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73667278
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73227672
23Parkinsons disease_Homo sapiens_hsa050121.73021218
24Mismatch repair_Homo sapiens_hsa034301.72923466
25Allograft rejection_Homo sapiens_hsa053301.72693802
26Herpes simplex infection_Homo sapiens_hsa051681.71944418
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67809331
28Phototransduction_Homo sapiens_hsa047441.66822271
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63190239
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57583347
31Nitrogen metabolism_Homo sapiens_hsa009101.56221188
32Primary immunodeficiency_Homo sapiens_hsa053401.55812591
33RNA polymerase_Homo sapiens_hsa030201.50550225
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49744678
35Homologous recombination_Homo sapiens_hsa034401.46678104
36Pyrimidine metabolism_Homo sapiens_hsa002401.45962360
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.44354213
38Protein export_Homo sapiens_hsa030601.38930534
39Linoleic acid metabolism_Homo sapiens_hsa005911.37411474
40Tryptophan metabolism_Homo sapiens_hsa003801.36957917
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36919556
42Hematopoietic cell lineage_Homo sapiens_hsa046401.35753973
43Folate biosynthesis_Homo sapiens_hsa007901.34954685
44Influenza A_Homo sapiens_hsa051641.34670155
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34667071
46Sulfur metabolism_Homo sapiens_hsa009201.34042148
47Type I diabetes mellitus_Homo sapiens_hsa049401.32254189
48Pertussis_Homo sapiens_hsa051331.32239302
49Asthma_Homo sapiens_hsa053101.29080488
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.27367167
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26329734
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25855365
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25816564
54Huntingtons disease_Homo sapiens_hsa050161.25815994
55TNF signaling pathway_Homo sapiens_hsa046681.25432937
56Nucleotide excision repair_Homo sapiens_hsa034201.24844136
57Ether lipid metabolism_Homo sapiens_hsa005651.24492373
58Osteoclast differentiation_Homo sapiens_hsa043801.22972628
59Rheumatoid arthritis_Homo sapiens_hsa053231.22832114
60Spliceosome_Homo sapiens_hsa030401.21596613
61Non-homologous end-joining_Homo sapiens_hsa034501.21088832
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20862118
63Tuberculosis_Homo sapiens_hsa051521.17652874
64Apoptosis_Homo sapiens_hsa042101.13268519
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12611545
66Cell cycle_Homo sapiens_hsa041101.10760070
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10369811
68One carbon pool by folate_Homo sapiens_hsa006701.09755895
69RNA degradation_Homo sapiens_hsa030181.08911837
70Vitamin digestion and absorption_Homo sapiens_hsa049771.05188924
71p53 signaling pathway_Homo sapiens_hsa041151.04824360
72Other glycan degradation_Homo sapiens_hsa005111.00969881
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00147395
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98517792
75Systemic lupus erythematosus_Homo sapiens_hsa053220.97268185
76Hepatitis B_Homo sapiens_hsa051610.96771797
77RNA transport_Homo sapiens_hsa030130.96693637
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96071090
79Epstein-Barr virus infection_Homo sapiens_hsa051690.92848592
80Shigellosis_Homo sapiens_hsa051310.92140422
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.91712720
82Steroid biosynthesis_Homo sapiens_hsa001000.90970496
83Alzheimers disease_Homo sapiens_hsa050100.90295312
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.90271753
85Salmonella infection_Homo sapiens_hsa051320.88783943
86Toxoplasmosis_Homo sapiens_hsa051450.88748635
87Pentose phosphate pathway_Homo sapiens_hsa000300.88081635
88Lysosome_Homo sapiens_hsa041420.88037279
89Basal transcription factors_Homo sapiens_hsa030220.86534613
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.86322227
91Retinol metabolism_Homo sapiens_hsa008300.84807639
92Selenocompound metabolism_Homo sapiens_hsa004500.83553173
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83356260
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83044098
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83038342
96Fatty acid elongation_Homo sapiens_hsa000620.82963054
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82382895
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79084543
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79036480
100Phagosome_Homo sapiens_hsa041450.77546195
101Complement and coagulation cascades_Homo sapiens_hsa046100.76789224
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76119339
103Metabolic pathways_Homo sapiens_hsa011000.75703521
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74537541
105Arachidonic acid metabolism_Homo sapiens_hsa005900.69379724
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69274143
107Caffeine metabolism_Homo sapiens_hsa002320.68674000
108Fanconi anemia pathway_Homo sapiens_hsa034600.68360553
109Circadian rhythm_Homo sapiens_hsa047100.68304540
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.68144008
111Sulfur relay system_Homo sapiens_hsa041220.68060727
112TGF-beta signaling pathway_Homo sapiens_hsa043500.67393369
113B cell receptor signaling pathway_Homo sapiens_hsa046620.66772109
114Viral carcinogenesis_Homo sapiens_hsa052030.65597678
115Glutathione metabolism_Homo sapiens_hsa004800.65068521
116Fatty acid degradation_Homo sapiens_hsa000710.61817561
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.61530308
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59218922
119African trypanosomiasis_Homo sapiens_hsa051430.58583043
120Hepatitis C_Homo sapiens_hsa051600.56297450
121Pyruvate metabolism_Homo sapiens_hsa006200.53874516
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53355052
123Olfactory transduction_Homo sapiens_hsa047400.52668805
124Autoimmune thyroid disease_Homo sapiens_hsa053200.52142996
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51299614
126Chemical carcinogenesis_Homo sapiens_hsa052040.51205551
127Fatty acid metabolism_Homo sapiens_hsa012120.51004342
128Purine metabolism_Homo sapiens_hsa002300.50782449
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.49868174
130mRNA surveillance pathway_Homo sapiens_hsa030150.49600154
131Fat digestion and absorption_Homo sapiens_hsa049750.48332696
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47772705
133Serotonergic synapse_Homo sapiens_hsa047260.47354834
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45128036
135Taste transduction_Homo sapiens_hsa047420.44971002
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44948447
137Hedgehog signaling pathway_Homo sapiens_hsa043400.44315593
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43857149
139HTLV-I infection_Homo sapiens_hsa051660.43765822
140Peroxisome_Homo sapiens_hsa041460.43286383
141T cell receptor signaling pathway_Homo sapiens_hsa046600.43231709
142Nicotine addiction_Homo sapiens_hsa050330.42808378
143Regulation of autophagy_Homo sapiens_hsa041400.41682348
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40784746
145Leukocyte transendothelial migration_Homo sapiens_hsa046700.40057954
146Viral myocarditis_Homo sapiens_hsa054160.38985470
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38873906
148Small cell lung cancer_Homo sapiens_hsa052220.38830855
149Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37376946
150Collecting duct acid secretion_Homo sapiens_hsa049660.36282519
151N-Glycan biosynthesis_Homo sapiens_hsa005100.35808976
152beta-Alanine metabolism_Homo sapiens_hsa004100.33808996
153Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33763850
154Mineral absorption_Homo sapiens_hsa049780.29831257
155Sphingolipid metabolism_Homo sapiens_hsa006000.27465711

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »