RBM8A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)5.19742324
2viral transcription (GO:0019083)5.06339659
3ribosomal small subunit biogenesis (GO:0042274)5.05371742
4translational termination (GO:0006415)4.95491459
5ribosomal small subunit assembly (GO:0000028)4.95464706
6DNA deamination (GO:0045006)4.80232353
7chaperone-mediated protein transport (GO:0072321)4.76768737
8ribosomal large subunit biogenesis (GO:0042273)4.58718842
9proteasome assembly (GO:0043248)4.47537109
10translational elongation (GO:0006414)4.36624250
11translational initiation (GO:0006413)4.31340668
12formation of translation preinitiation complex (GO:0001731)4.30220915
13ribonucleoprotein complex biogenesis (GO:0022613)4.29141703
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27934132
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.26733036
16DNA strand elongation involved in DNA replication (GO:0006271)4.24952822
17cotranslational protein targeting to membrane (GO:0006613)4.19187083
18DNA replication checkpoint (GO:0000076)4.16600400
19protein targeting to ER (GO:0045047)4.16264322
20telomere maintenance via semi-conservative replication (GO:0032201)4.13467684
21DNA replication initiation (GO:0006270)4.06072174
22* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.03779748
23DNA strand elongation (GO:0022616)4.03269965
24spliceosomal snRNP assembly (GO:0000387)3.96597634
25ribosome biogenesis (GO:0042254)3.96143575
26mitotic metaphase plate congression (GO:0007080)3.94933552
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.94403129
28cellular protein complex disassembly (GO:0043624)3.94142040
29viral life cycle (GO:0019058)3.93068351
30protein localization to endoplasmic reticulum (GO:0070972)3.92368691
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.87122779
32rRNA modification (GO:0000154)3.84997161
33nucleobase biosynthetic process (GO:0046112)3.84645899
34ribosome assembly (GO:0042255)3.83883532
35rRNA processing (GO:0006364)3.83620502
36CENP-A containing nucleosome assembly (GO:0034080)3.80786783
37termination of RNA polymerase III transcription (GO:0006386)3.78583924
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.78583924
39purine nucleobase biosynthetic process (GO:0009113)3.77425781
40telomere maintenance via recombination (GO:0000722)3.75997082
41protein deneddylation (GO:0000338)3.75236138
42chromatin remodeling at centromere (GO:0031055)3.74680421
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.73343323
44establishment of viral latency (GO:0019043)3.71358986
45rRNA metabolic process (GO:0016072)3.70585347
46positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.69230476
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.69165362
48spliceosomal complex assembly (GO:0000245)3.67638701
49translation (GO:0006412)3.67167298
50kinetochore assembly (GO:0051382)3.66527946
51energy coupled proton transport, down electrochemical gradient (GO:0015985)3.63104571
52ATP synthesis coupled proton transport (GO:0015986)3.63104571
53kinetochore organization (GO:0051383)3.60662372
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54909181
55negative regulation of ligase activity (GO:0051352)3.54909181
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54104870
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54104870
58mitotic recombination (GO:0006312)3.52792123
59protein complex disassembly (GO:0043241)3.52482897
60protein localization to kinetochore (GO:0034501)3.48835754
617-methylguanosine mRNA capping (GO:0006370)3.46956093
62protein targeting to mitochondrion (GO:0006626)3.44302169
63DNA ligation (GO:0006266)3.44218380
64establishment of integrated proviral latency (GO:0075713)3.42590226
657-methylguanosine RNA capping (GO:0009452)3.40363530
66RNA capping (GO:0036260)3.40363530
67transcription-coupled nucleotide-excision repair (GO:0006283)3.40071081
68DNA replication-independent nucleosome assembly (GO:0006336)3.39803013
69DNA replication-independent nucleosome organization (GO:0034724)3.39803013
70cellular component biogenesis (GO:0044085)3.38466105
71metaphase plate congression (GO:0051310)3.37935726
72DNA damage response, detection of DNA damage (GO:0042769)3.37817529
73telomere maintenance via telomere lengthening (GO:0010833)3.37685190
74regulation of ubiquitin-protein transferase activity (GO:0051438)3.37357996
75pseudouridine synthesis (GO:0001522)3.36160125
76macromolecular complex disassembly (GO:0032984)3.35650009
77DNA replication-dependent nucleosome organization (GO:0034723)3.35183143
78DNA replication-dependent nucleosome assembly (GO:0006335)3.35183143
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.34125237
80DNA double-strand break processing (GO:0000729)3.30650941
81mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30110476
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28677209
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28677209
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28677209
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28254416
86intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28254416
87signal transduction involved in DNA damage checkpoint (GO:0072422)3.28153491
88signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28153491
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27997924
90DNA unwinding involved in DNA replication (GO:0006268)3.27798229
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24788376
92regulation of ligase activity (GO:0051340)3.24691317
93signal transduction involved in cell cycle checkpoint (GO:0072395)3.24378637
94* nuclear-transcribed mRNA catabolic process (GO:0000956)3.23724840
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23495686
96protein localization to mitochondrion (GO:0070585)3.22988361
97establishment of protein localization to mitochondrion (GO:0072655)3.21035220
98regulation of mitotic spindle checkpoint (GO:1903504)3.20994850
99regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.20994850
100nucleotide-excision repair, DNA gap filling (GO:0006297)3.20231633
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19386502
102mitotic sister chromatid segregation (GO:0000070)3.18537160
103histone exchange (GO:0043486)3.16032616
104nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15515698
105transcription from RNA polymerase I promoter (GO:0006360)3.15166600
106DNA catabolic process, exonucleolytic (GO:0000738)3.14914678
107regulation of cellular amino acid metabolic process (GO:0006521)3.13709240
108cullin deneddylation (GO:0010388)3.12857876
109positive regulation of ligase activity (GO:0051351)3.12240548
110respiratory electron transport chain (GO:0022904)3.12063345
111transcription elongation from RNA polymerase I promoter (GO:0006362)3.11736191
112termination of RNA polymerase I transcription (GO:0006363)3.10865199
113mitochondrial respiratory chain complex assembly (GO:0033108)3.10768786
114rRNA methylation (GO:0031167)3.09592493
115establishment of protein localization to mitochondrial membrane (GO:0090151)3.08507825
116* mRNA catabolic process (GO:0006402)3.06464941
117cell cycle G1/S phase transition (GO:0044843)3.06392765
118G1/S transition of mitotic cell cycle (GO:0000082)3.06392765
119protein localization to chromosome, centromeric region (GO:0071459)3.06317752
120electron transport chain (GO:0022900)3.05622754
121maturation of 5.8S rRNA (GO:0000460)3.05034406
122protein complex biogenesis (GO:0070271)3.04978528
123histone mRNA metabolic process (GO:0008334)3.04809541
124regulation of mitochondrial translation (GO:0070129)3.03309628
125viral mRNA export from host cell nucleus (GO:0046784)3.02557844
126mitochondrial respiratory chain complex I assembly (GO:0032981)3.01121157
127NADH dehydrogenase complex assembly (GO:0010257)3.01121157
128mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01121157
129regulation of nuclear cell cycle DNA replication (GO:0033262)3.00647719
130establishment of chromosome localization (GO:0051303)2.99749885
131mitochondrial RNA metabolic process (GO:0000959)2.96858116
132DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.96584578
133regulation of helicase activity (GO:0051095)2.94140122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.73696947
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.59472023
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.86152933
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71547929
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.55824591
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.55136626
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38860208
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.35380325
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.33863639
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.31832153
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.29270686
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.14383236
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.06725959
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03099341
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.02807756
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.84827753
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.79924524
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.73164583
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60742112
20* XRN2_22483619_ChIP-Seq_HELA_Human2.57770962
21* VDR_23849224_ChIP-Seq_CD4+_Human2.45337595
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41759839
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38898153
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31284129
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29524710
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25321409
27DCP1A_22483619_ChIP-Seq_HELA_Human2.17384098
28* TTF2_22483619_ChIP-Seq_HELA_Human2.09084021
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07934675
30FOXP3_21729870_ChIP-Seq_TREG_Human2.06705051
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04655907
32GABP_19822575_ChIP-Seq_HepG2_Human1.96839728
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94069758
34* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93720604
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93236850
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90582655
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.88808297
38* ELK1_19687146_ChIP-ChIP_HELA_Human1.83035027
39* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82398153
40AR_21909140_ChIP-Seq_LNCAP_Human1.71999302
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71777241
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62246768
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.61962210
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60532080
45* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58371867
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57922633
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.57321920
48* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57042885
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48223826
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47116822
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46481390
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44797047
53CIITA_25753668_ChIP-Seq_RAJI_Human1.44423255
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42186129
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.40613689
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38432225
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36177966
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35383573
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33374270
60* KDM5A_27292631_Chip-Seq_BREAST_Human1.33154536
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32282474
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31131847
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29778194
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29178245
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27702969
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27702969
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27702969
68* ELK1_22589737_ChIP-Seq_MCF10A_Human1.27138829
69ZNF274_21170338_ChIP-Seq_K562_Hela1.26181987
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25000287
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23258956
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19640644
73* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15879082
74MYC_18940864_ChIP-ChIP_HL60_Human1.13848307
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13604356
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13588915
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13323840
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10048203
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09654406
80* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09105031
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08353254
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.07503391
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06192105
84EWS_26573619_Chip-Seq_HEK293_Human1.03544599
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02681742
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.02314035
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00665461
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.00333701
89SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00063051
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99797825
91OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98030542
92RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96872964
93NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96643226
94TFEB_21752829_ChIP-Seq_HELA_Human0.96360169
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95653393
96NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92644823
97CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92185997
98IRF1_19129219_ChIP-ChIP_H3396_Human0.91861106
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91210250
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90100884
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85590329
102MYC_22102868_ChIP-Seq_BL_Human0.83590642
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.83343395
104* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82672221
105* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82663016
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82620916
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81127396
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80996069
109* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80458446
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.79787860
111* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79473577
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77905550
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76998913
114EGR1_19374776_ChIP-ChIP_THP-1_Human0.76200082
115SALL1_21062744_ChIP-ChIP_HESCs_Human0.73160628
116ELF5_23300383_ChIP-Seq_T47D_Human0.71668182
117FUS_26573619_Chip-Seq_HEK293_Human0.71491605
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.66900083
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.65654004
120* TP53_22573176_ChIP-Seq_HFKS_Human0.63447089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.73777841
2MP0004957_abnormal_blastocyst_morpholog4.67522410
3MP0003111_abnormal_nucleus_morphology4.42779288
4MP0010094_abnormal_chromosome_stability4.27054229
5MP0003077_abnormal_cell_cycle4.00562271
6MP0008057_abnormal_DNA_replication3.80285658
7MP0008058_abnormal_DNA_repair3.38979578
8MP0008932_abnormal_embryonic_tissue3.13780006
9MP0008007_abnormal_cellular_replicative2.80347337
10MP0003786_premature_aging2.35901243
11MP0003718_maternal_effect2.32822026
12MP0003123_paternal_imprinting2.27806460
13MP0006292_abnormal_olfactory_placode2.17929914
14MP0001730_embryonic_growth_arrest2.15060807
15MP0009379_abnormal_foot_pigmentation2.08596641
16MP0000350_abnormal_cell_proliferation2.08362999
17MP0003315_abnormal_perineum_morphology1.90038070
18MP0008877_abnormal_DNA_methylation1.80697121
19MP0010030_abnormal_orbit_morphology1.79093077
20MP0000372_irregular_coat_pigmentation1.65863602
21MP0001697_abnormal_embryo_size1.63870346
22MP0003941_abnormal_skin_development1.62374361
23MP0005380_embryogenesis_phenotype1.62206423
24MP0001672_abnormal_embryogenesis/_devel1.62206423
25MP0002396_abnormal_hematopoietic_system1.55809437
26MP0002736_abnormal_nociception_after1.54666187
27MP0002085_abnormal_embryonic_tissue1.53123434
28MP0004133_heterotaxia1.51461809
29MP0009697_abnormal_copulation1.47706296
30MP0002080_prenatal_lethality1.47523870
31MP0003567_abnormal_fetal_cardiomyocyte1.43635941
32MP0000313_abnormal_cell_death1.43577597
33MP0003136_yellow_coat_color1.42266927
34MP0003984_embryonic_growth_retardation1.37097640
35MP0009333_abnormal_splenocyte_physiolog1.35028131
36MP0002088_abnormal_embryonic_growth/wei1.34364057
37MP0000490_abnormal_crypts_of1.33511213
38MP0001293_anophthalmia1.32298455
39MP0002084_abnormal_developmental_patter1.31982772
40MP0002210_abnormal_sex_determination1.29705110
41MP0002653_abnormal_ependyma_morphology1.25234548
42MP0005253_abnormal_eye_physiology1.23134815
43MP0001984_abnormal_olfaction1.22873078
44MP0003890_abnormal_embryonic-extraembry1.18745242
45MP0002019_abnormal_tumor_incidence1.17743614
46MP0002102_abnormal_ear_morphology1.16418676
47MP0003186_abnormal_redox_activity1.15788902
48MP0003121_genomic_imprinting1.14860721
49MP0002160_abnormal_reproductive_system1.14347606
50MP0003119_abnormal_digestive_system1.12766733
51MP0001145_abnormal_male_reproductive1.12143774
52MP0004197_abnormal_fetal_growth/weight/1.11454179
53MP0002086_abnormal_extraembryonic_tissu1.06627907
54MP0002938_white_spotting1.06151801
55MP0002132_abnormal_respiratory_system1.03413247
56MP0000049_abnormal_middle_ear1.03130667
57MP0002234_abnormal_pharynx_morphology1.02003084
58MP0005389_reproductive_system_phenotype1.01822044
59MP0010352_gastrointestinal_tract_polyps1.01692356
60MP0003806_abnormal_nucleotide_metabolis1.01171685
61MP0002233_abnormal_nose_morphology1.00888801
62MP0001346_abnormal_lacrimal_gland0.99844444
63MP0000647_abnormal_sebaceous_gland0.99032464
64MP0003937_abnormal_limbs/digits/tail_de0.98659573
65MP0000358_abnormal_cell_content/0.97901777
66MP0006035_abnormal_mitochondrial_morpho0.97569165
67MP0008789_abnormal_olfactory_epithelium0.95140682
68MP0000537_abnormal_urethra_morphology0.95100876
69MP0004147_increased_porphyrin_level0.94069820
70MP0005391_vision/eye_phenotype0.93356001
71MP0010307_abnormal_tumor_latency0.92159445
72MP0001286_abnormal_eye_development0.92054124
73MP0000653_abnormal_sex_gland0.91982970
74MP0005075_abnormal_melanosome_morpholog0.90608904
75MP0005187_abnormal_penis_morphology0.89362224
76MP0002111_abnormal_tail_morphology0.89111529
77MP0002277_abnormal_respiratory_mucosa0.88611933
78MP0003938_abnormal_ear_development0.88439144
79MP0001929_abnormal_gametogenesis0.87369677
80MP0001919_abnormal_reproductive_system0.85884797
81MP0002751_abnormal_autonomic_nervous0.85579195
82MP0008872_abnormal_physiological_respon0.84642341
83MP0009053_abnormal_anal_canal0.84003068
84MP0000631_abnormal_neuroendocrine_gland0.83282142
85MP0002697_abnormal_eye_size0.83175160
86MP0000703_abnormal_thymus_morphology0.82528333
87MP0009672_abnormal_birth_weight0.82302566
88MP0005084_abnormal_gallbladder_morpholo0.82070146
89MP0001905_abnormal_dopamine_level0.81722431
90MP0001119_abnormal_female_reproductive0.79797349
91MP0000566_synostosis0.78880379
92MP0001968_abnormal_touch/_nociception0.77136981
93MP0003698_abnormal_male_reproductive0.77095652
94MP0006036_abnormal_mitochondrial_physio0.76575597
95MP0000750_abnormal_muscle_regeneration0.76227507
96MP0002638_abnormal_pupillary_reflex0.75472638
97MP0002163_abnormal_gland_morphology0.75008003
98MP0000858_altered_metastatic_potential0.74903256
99MP0001727_abnormal_embryo_implantation0.74238089
100MP0002722_abnormal_immune_system0.71127171
101MP0005408_hypopigmentation0.70225570
102MP0001529_abnormal_vocalization0.69824977
103MP0003763_abnormal_thymus_physiology0.69641746
104MP0001764_abnormal_homeostasis0.69449532
105MP0004808_abnormal_hematopoietic_stem0.69427462
106MP0000428_abnormal_craniofacial_morphol0.68471539
107MP0003936_abnormal_reproductive_system0.68340355
108MP0005384_cellular_phenotype0.66089624
109MP0008995_early_reproductive_senescence0.65707607
110MP0001853_heart_inflammation0.65369952
111MP0000516_abnormal_urinary_system0.64596743
112MP0005367_renal/urinary_system_phenotyp0.64596743
113MP0001188_hyperpigmentation0.63840357
114MP0004381_abnormal_hair_follicle0.63839883
115MP0002095_abnormal_skin_pigmentation0.63281459
116MP0003861_abnormal_nervous_system0.63170411
117MP0000689_abnormal_spleen_morphology0.62533310
118MP0003880_abnormal_central_pattern0.62511614
119MP0002398_abnormal_bone_marrow0.61945123
120MP0002092_abnormal_eye_morphology0.61834638
121MP0005499_abnormal_olfactory_system0.61206089
122MP0005394_taste/olfaction_phenotype0.61206089
123MP0003221_abnormal_cardiomyocyte_apopto0.60544440
124MP0006072_abnormal_retinal_apoptosis0.60472106
125MP0003755_abnormal_palate_morphology0.60391453
126MP0000432_abnormal_head_morphology0.57504160

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.31146583
2Abnormality of cells of the erythroid lineage (HP:0012130)4.85099695
3Birth length less than 3rd percentile (HP:0003561)4.51002072
4Abnormal number of erythroid precursors (HP:0012131)4.50606086
5Breast hypoplasia (HP:0003187)4.49304884
6Macrocytic anemia (HP:0001972)3.92417197
7Pallor (HP:0000980)3.49926069
8Oral leukoplakia (HP:0002745)3.49298082
9Cerebral hypomyelination (HP:0006808)3.47659302
10Rough bone trabeculation (HP:0100670)3.42881896
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.34300175
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.33578821
13Chromsome breakage (HP:0040012)3.33500058
14Cerebral edema (HP:0002181)3.11313508
15* Patellar aplasia (HP:0006443)3.03935496
16* Aplasia/Hypoplasia of the patella (HP:0006498)2.98230985
17Aplastic anemia (HP:0001915)2.97425828
18Abnormality of the preputium (HP:0100587)2.94400397
19Absent thumb (HP:0009777)2.91827483
20Trismus (HP:0000211)2.91573490
21Colon cancer (HP:0003003)2.90484169
22Supernumerary spleens (HP:0009799)2.81547658
23Multiple enchondromatosis (HP:0005701)2.75805144
24Renal Fanconi syndrome (HP:0001994)2.75577945
25Abnormality of the anterior horn cell (HP:0006802)2.73769423
26Degeneration of anterior horn cells (HP:0002398)2.73769423
27Triphalangeal thumb (HP:0001199)2.70195226
28Lactic acidosis (HP:0003128)2.69187987
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.68764550
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.67217107
31Increased hepatocellular lipid droplets (HP:0006565)2.63134192
32Selective tooth agenesis (HP:0001592)2.62296275
33Microretrognathia (HP:0000308)2.61284321
34Acute necrotizing encephalopathy (HP:0006965)2.59576073
35* Meckel diverticulum (HP:0002245)2.59290569
36Mitochondrial inheritance (HP:0001427)2.58397306
37* Absent radius (HP:0003974)2.58368629
38Abnormality of the labia minora (HP:0012880)2.57487511
39Cleft eyelid (HP:0000625)2.56603817
40Abnormality of chromosome stability (HP:0003220)2.56068507
41Abnormal trabecular bone morphology (HP:0100671)2.53997919
42Secondary amenorrhea (HP:0000869)2.53970825
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53185531
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53185531
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.53145140
46Premature graying of hair (HP:0002216)2.51288444
47Increased intramyocellular lipid droplets (HP:0012240)2.50306576
48* Abnormality of the ileum (HP:0001549)2.46991232
49Increased CSF lactate (HP:0002490)2.45848194
50Hepatocellular necrosis (HP:0001404)2.43184996
51Premature ovarian failure (HP:0008209)2.41864480
5211 pairs of ribs (HP:0000878)2.41611245
53* Aplasia involving forearm bones (HP:0009822)2.41176043
54* Absent forearm bone (HP:0003953)2.41176043
55Neoplasm of the pancreas (HP:0002894)2.40953857
56Bone marrow hypocellularity (HP:0005528)2.40696147
57Abnormal lung lobation (HP:0002101)2.40116416
58Duodenal stenosis (HP:0100867)2.36425634
59Small intestinal stenosis (HP:0012848)2.36425634
60Increased serum lactate (HP:0002151)2.35238959
61Respiratory failure (HP:0002878)2.33733491
62Leukodystrophy (HP:0002415)2.32351487
633-Methylglutaconic aciduria (HP:0003535)2.31833680
64Methylmalonic acidemia (HP:0002912)2.31048281
65Impulsivity (HP:0100710)2.30348540
66Abnormal number of incisors (HP:0011064)2.29653444
67Sparse eyelashes (HP:0000653)2.27094449
68Microvesicular hepatic steatosis (HP:0001414)2.25949582
69Methylmalonic aciduria (HP:0012120)2.23819967
70* Horseshoe kidney (HP:0000085)2.23359384
71Type I transferrin isoform profile (HP:0003642)2.23309473
72Abnormal mitochondria in muscle tissue (HP:0008316)2.23175456
73Myelodysplasia (HP:0002863)2.21536898
74Hypoplasia of the radius (HP:0002984)2.21415506
75Ependymoma (HP:0002888)2.21329292
76Optic disc pallor (HP:0000543)2.20671004
77Tracheoesophageal fistula (HP:0002575)2.20208347
78Agnosia (HP:0010524)2.18409282
79Medulloblastoma (HP:0002885)2.18323941
80Lipid accumulation in hepatocytes (HP:0006561)2.17823579
81Abnormality of glycolysis (HP:0004366)2.16076828
82Increased serum pyruvate (HP:0003542)2.16076828
83Pendular nystagmus (HP:0012043)2.14164418
84Atresia of the external auditory canal (HP:0000413)2.14110815
85Respiratory difficulties (HP:0002880)2.13605606
86Poor head control (HP:0002421)2.12023849
87Exertional dyspnea (HP:0002875)2.11735819
88Cellular immunodeficiency (HP:0005374)2.11573971
89Abnormality of the pons (HP:0007361)2.09177658
90Glossoptosis (HP:0000162)2.08419911
91Hepatic necrosis (HP:0002605)2.05538782
92Hypoplasia of the pons (HP:0012110)2.03436986
93Concave nail (HP:0001598)2.03127139
94Rhabdomyosarcoma (HP:0002859)2.00531117
95Congenital, generalized hypertrichosis (HP:0004540)2.00098609
96Duplicated collecting system (HP:0000081)1.99969624
97Stenosis of the external auditory canal (HP:0000402)1.99716030
98Retinal dysplasia (HP:0007973)1.97799441
99Lethargy (HP:0001254)1.97601064
100Facial cleft (HP:0002006)1.96983813
101Increased muscle lipid content (HP:0009058)1.96512929
102Abnormality of the duodenum (HP:0002246)1.96178268
103Muscle fiber atrophy (HP:0100295)1.93941349
104Sloping forehead (HP:0000340)1.93855158
105* Carpal bone hypoplasia (HP:0001498)1.93250368
106Pancytopenia (HP:0001876)1.91488409
107Hyperglycinemia (HP:0002154)1.89975494
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89729848
109Abnormal protein N-linked glycosylation (HP:0012347)1.89729848
110Abnormal protein glycosylation (HP:0012346)1.89729848
111Abnormal glycosylation (HP:0012345)1.89729848
112Progressive muscle weakness (HP:0003323)1.89082432
113CNS hypomyelination (HP:0003429)1.88667246
114Abdominal situs inversus (HP:0003363)1.88289325
115Abnormality of abdominal situs (HP:0011620)1.88289325
116Depressed nasal ridge (HP:0000457)1.85568144
117Progressive macrocephaly (HP:0004481)1.84920724
118Abnormality of methionine metabolism (HP:0010901)1.83172665
119Postnatal microcephaly (HP:0005484)1.81309846
120Abnormality of alanine metabolism (HP:0010916)1.81172382
121Hyperalaninemia (HP:0003348)1.81172382
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81172382
123CNS demyelination (HP:0007305)1.80772406
124Acute encephalopathy (HP:0006846)1.78859401
125Rib fusion (HP:0000902)1.77590619
126Exercise intolerance (HP:0003546)1.77309259
127Short thumb (HP:0009778)1.75370855
128Cortical dysplasia (HP:0002539)1.72206248
129Abnormality of the carotid arteries (HP:0005344)1.69671772
130Glioma (HP:0009733)1.68985888
131Preaxial hand polydactyly (HP:0001177)1.66998292
132Abnormality of serum amino acid levels (HP:0003112)1.65210413
133Emotional lability (HP:0000712)1.64305847
134Short tibia (HP:0005736)1.63194852
135Absent septum pellucidum (HP:0001331)1.62674674
136Sclerocornea (HP:0000647)1.62028321
137Pancreatic fibrosis (HP:0100732)1.60648412

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.49050274
2WEE14.52042924
3VRK23.84754310
4EIF2AK13.55950954
5STK163.08248209
6CDC73.05354454
7NME22.93746279
8TRIM282.88718404
9PLK42.82005482
10TLK12.74191238
11TSSK62.24055731
12VRK12.20679830
13TESK22.16286675
14EIF2AK32.11762486
15TTK2.10356175
16EPHA22.09956960
17ACVR1B2.01400655
18MKNK11.99584224
19NEK21.98165757
20PLK11.96282807
21BRSK21.94848040
22NUAK11.88347042
23DYRK31.86323082
24MKNK21.71825248
25CDK71.64945358
26AURKB1.58094122
27RPS6KB21.51102239
28* SRPK11.50606369
29PLK31.50378173
30AURKA1.46135689
31MAP4K21.42611463
32NEK11.42064186
33PNCK1.34570338
34NME11.32893719
35PBK1.28811248
36PIM21.27746111
37CHEK21.27679043
38ATR1.24626363
39BRSK11.18622814
40WNK31.18473683
41RPS6KA41.17475046
42DYRK21.15465587
43TAF11.13298794
44ZAK1.11621718
45PAK41.11088776
46MAP2K71.10748759
47ERBB31.07073428
48PDK21.06428202
49KDR1.05432713
50PASK1.03090258
51IRAK30.99596224
52CHEK10.97893246
53TXK0.96887202
54EIF2AK20.96004445
55MAP3K80.92957926
56CSNK1G20.92277118
57CSNK1G10.92021017
58MAP3K40.90211922
59TGFBR10.89526176
60CSNK1A1L0.89512138
61CDK120.88170365
62CDK80.87458003
63MST40.86440050
64CSNK2A10.82071453
65SIK30.81888208
66CSNK2A20.80016499
67BRAF0.76796140
68TESK10.76715425
69PRKCI0.76464375
70PAK10.76452784
71CCNB10.75762438
72CDK40.75428321
73STK40.75024685
74MAP3K110.74921885
75BMPR1B0.74889693
76STK100.72326813
77LIMK10.72211521
78RPS6KA50.70721322
79PLK20.69983129
80CDK20.68488358
81STK38L0.65505717
82AKT30.64559425
83ATM0.64501427
84DAPK10.62616973
85BRD40.62512564
86CDK190.61173061
87LATS20.57768843
88PIM10.57679967
89MINK10.53044458
90CDK10.51038012
91ABL20.48958406
92LRRK20.48463318
93MUSK0.48252315
94ILK0.47343563
95INSRR0.47106856
96IRAK40.46042455
97CDK30.44205688
98ERBB40.41024271
99MAPKAPK30.37990980
100CSNK1E0.36117508
101CLK10.34220045
102PINK10.33907718
103MAP3K120.33748607
104SCYL20.33661978
105BLK0.33448904
106AKT20.33078795
107CSNK1A10.32816881
108ADRBK20.32371595
109CDK180.31741728
110ALK0.31369581
111YES10.31231627
112BCR0.28326754
113TNIK0.27731729
114MELK0.26598583
115MARK30.25271621
116BCKDK0.25145861
117TAOK20.23806690
118IKBKB0.23476414
119CDK150.23468200
120WNK40.22719402
121CSNK1G30.21476573
122DAPK30.20891481
123CDK11A0.19000362
124PRKDC0.18702496
125NLK0.17723428
126ARAF0.14420978
127CDK140.14198775
128GRK10.14185091
129UHMK10.12614928
130MAPKAPK20.12080618
131IRAK20.09992812

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.88377388
2Proteasome_Homo sapiens_hsa030504.32259970
3DNA replication_Homo sapiens_hsa030304.30964938
4RNA polymerase_Homo sapiens_hsa030204.01740863
5Mismatch repair_Homo sapiens_hsa034303.75191717
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.65633824
7* Spliceosome_Homo sapiens_hsa030403.50309244
8Homologous recombination_Homo sapiens_hsa034402.98884788
9* RNA transport_Homo sapiens_hsa030132.86178906
10Nucleotide excision repair_Homo sapiens_hsa034202.70942223
11Pyrimidine metabolism_Homo sapiens_hsa002402.70626796
12Base excision repair_Homo sapiens_hsa034102.62421784
13Cell cycle_Homo sapiens_hsa041102.24470004
14Fanconi anemia pathway_Homo sapiens_hsa034602.18592823
15One carbon pool by folate_Homo sapiens_hsa006702.12880479
16Basal transcription factors_Homo sapiens_hsa030222.11530030
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01975140
18RNA degradation_Homo sapiens_hsa030181.86410875
19Non-homologous end-joining_Homo sapiens_hsa034501.75652947
20Oxidative phosphorylation_Homo sapiens_hsa001901.65086233
21Parkinsons disease_Homo sapiens_hsa050121.61139217
22Huntingtons disease_Homo sapiens_hsa050161.47578131
23Protein export_Homo sapiens_hsa030601.46378294
24Purine metabolism_Homo sapiens_hsa002301.44883986
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43402766
26* mRNA surveillance pathway_Homo sapiens_hsa030151.40344146
27p53 signaling pathway_Homo sapiens_hsa041151.38019955
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28947939
29Epstein-Barr virus infection_Homo sapiens_hsa051691.23167725
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19042673
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10968562
32Propanoate metabolism_Homo sapiens_hsa006401.06613834
33Folate biosynthesis_Homo sapiens_hsa007901.05731854
34Pyruvate metabolism_Homo sapiens_hsa006200.99134769
35Fatty acid elongation_Homo sapiens_hsa000620.96052648
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91921240
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89283900
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88113300
39Steroid biosynthesis_Homo sapiens_hsa001000.85011649
40Systemic lupus erythematosus_Homo sapiens_hsa053220.84551616
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83803570
42Alzheimers disease_Homo sapiens_hsa050100.82239863
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78091738
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76627179
45Oocyte meiosis_Homo sapiens_hsa041140.75838580
46Sulfur relay system_Homo sapiens_hsa041220.75359160
47Vitamin B6 metabolism_Homo sapiens_hsa007500.74338633
48Herpes simplex infection_Homo sapiens_hsa051680.72623504
49Pentose phosphate pathway_Homo sapiens_hsa000300.72442936
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67023528
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64075380
52Antigen processing and presentation_Homo sapiens_hsa046120.63739153
53Glutathione metabolism_Homo sapiens_hsa004800.62136130
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.62099439
55Viral carcinogenesis_Homo sapiens_hsa052030.61105298
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59716464
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55441764
58HTLV-I infection_Homo sapiens_hsa051660.53167226
59Peroxisome_Homo sapiens_hsa041460.52820347
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.50487130
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.49247616
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49142368
63Arachidonic acid metabolism_Homo sapiens_hsa005900.48416515
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48080460
65Biosynthesis of amino acids_Homo sapiens_hsa012300.46247660
66Sulfur metabolism_Homo sapiens_hsa009200.42518217
67Basal cell carcinoma_Homo sapiens_hsa052170.42336971
68Thyroid cancer_Homo sapiens_hsa052160.41391255
69Phototransduction_Homo sapiens_hsa047440.40718701
70Regulation of autophagy_Homo sapiens_hsa041400.40663579
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40500989
72Metabolic pathways_Homo sapiens_hsa011000.39373488
73Butanoate metabolism_Homo sapiens_hsa006500.37704831
74Primary immunodeficiency_Homo sapiens_hsa053400.36922812
75Hippo signaling pathway_Homo sapiens_hsa043900.36028410
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35619035
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34224151
78Legionellosis_Homo sapiens_hsa051340.33461259
79Graft-versus-host disease_Homo sapiens_hsa053320.33005924
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32481970
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30969081
82Fructose and mannose metabolism_Homo sapiens_hsa000510.30497694
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29258403
84TGF-beta signaling pathway_Homo sapiens_hsa043500.28998588
85Selenocompound metabolism_Homo sapiens_hsa004500.28643638
86Cardiac muscle contraction_Homo sapiens_hsa042600.28622686
87Collecting duct acid secretion_Homo sapiens_hsa049660.28489723
88MicroRNAs in cancer_Homo sapiens_hsa052060.27704444
89Hedgehog signaling pathway_Homo sapiens_hsa043400.27557726
90Alcoholism_Homo sapiens_hsa050340.26278213
91Allograft rejection_Homo sapiens_hsa053300.23852240
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22482299
93Apoptosis_Homo sapiens_hsa042100.22368978
94Notch signaling pathway_Homo sapiens_hsa043300.22259076
95Carbon metabolism_Homo sapiens_hsa012000.22097016
96Fatty acid metabolism_Homo sapiens_hsa012120.21546294
97Asthma_Homo sapiens_hsa053100.21515799
98N-Glycan biosynthesis_Homo sapiens_hsa005100.20955422
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20466170
100Small cell lung cancer_Homo sapiens_hsa052220.19352885
101Shigellosis_Homo sapiens_hsa051310.18950279
102Arginine and proline metabolism_Homo sapiens_hsa003300.17964514
103Linoleic acid metabolism_Homo sapiens_hsa005910.17376964
104Nitrogen metabolism_Homo sapiens_hsa009100.16631590
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16484507
106beta-Alanine metabolism_Homo sapiens_hsa004100.16386215
107Galactose metabolism_Homo sapiens_hsa000520.15676366
108Autoimmune thyroid disease_Homo sapiens_hsa053200.15390180
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14971639
110Measles_Homo sapiens_hsa051620.14861471
111Pathways in cancer_Homo sapiens_hsa052000.14554309
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.14545275
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13433878
114Colorectal cancer_Homo sapiens_hsa052100.11721095
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11584453
116Wnt signaling pathway_Homo sapiens_hsa043100.10945100
117Hematopoietic cell lineage_Homo sapiens_hsa046400.10683065
118Bladder cancer_Homo sapiens_hsa052190.10388727
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10073020
120Caffeine metabolism_Homo sapiens_hsa002320.09599035
121Hepatitis B_Homo sapiens_hsa051610.08781859
122Tryptophan metabolism_Homo sapiens_hsa003800.07666753
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.07501028
124HIF-1 signaling pathway_Homo sapiens_hsa040660.07344401
125Tight junction_Homo sapiens_hsa045300.06690394
126Vibrio cholerae infection_Homo sapiens_hsa051100.04504767
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02807995
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.01576767

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