RBM8B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.77519777
2ATP synthesis coupled proton transport (GO:0015986)6.36828536
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.36828536
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.85503799
5viral transcription (GO:0019083)5.54714680
6translational termination (GO:0006415)5.39837371
7neuron fate determination (GO:0048664)5.20217310
8ribosomal small subunit assembly (GO:0000028)5.11864327
9positive regulation of male gonad development (GO:2000020)4.96967800
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.96141568
11regulation of male gonad development (GO:2000018)4.93157859
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.81036687
13cotranslational protein targeting to membrane (GO:0006613)4.79119790
14protein targeting to ER (GO:0045047)4.76703341
15rRNA modification (GO:0000154)4.71928008
16translational elongation (GO:0006414)4.61227980
17mitochondrial respiratory chain complex I assembly (GO:0032981)4.60197749
18NADH dehydrogenase complex assembly (GO:0010257)4.60197749
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.60197749
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.51885182
21protein localization to endoplasmic reticulum (GO:0070972)4.42139833
22negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.41382579
23respiratory electron transport chain (GO:0022904)4.35738292
24protein complex biogenesis (GO:0070271)4.35592520
25electron transport chain (GO:0022900)4.28428589
26rRNA methylation (GO:0031167)4.24751011
27ribosomal small subunit biogenesis (GO:0042274)4.22443442
28cellular protein complex disassembly (GO:0043624)4.16668611
29maturation of SSU-rRNA (GO:0030490)4.12303883
30chaperone-mediated protein transport (GO:0072321)4.10140435
31water-soluble vitamin biosynthetic process (GO:0042364)3.95124032
32mitochondrial respiratory chain complex assembly (GO:0033108)3.87686345
33translational initiation (GO:0006413)3.84414128
34viral life cycle (GO:0019058)3.82012175
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.80467072
36gonadal mesoderm development (GO:0007506)3.71635339
37retinal ganglion cell axon guidance (GO:0031290)3.64674976
38response to pheromone (GO:0019236)3.64065415
39cell morphogenesis involved in neuron differentiation (GO:0048667)3.62672445
40ATP biosynthetic process (GO:0006754)3.56509789
41positive regulation of megakaryocyte differentiation (GO:0045654)3.49983293
42intracellular protein transmembrane import (GO:0044743)3.46876628
43purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.44811685
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.44525549
45negative regulation of DNA-templated transcription, elongation (GO:0032785)3.43515106
46protein complex disassembly (GO:0043241)3.41893004
47inner mitochondrial membrane organization (GO:0007007)3.39472566
48translation (GO:0006412)3.37438288
49midbrain development (GO:0030901)3.35664945
50proteasome assembly (GO:0043248)3.34922658
51negative regulation of epidermis development (GO:0045683)3.34633072
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27161849
53protein neddylation (GO:0045116)3.25792915
54macromolecular complex disassembly (GO:0032984)3.21579892
55ribosomal large subunit biogenesis (GO:0042273)3.17614758
56protein targeting to membrane (GO:0006612)3.13938234
57hydrogen ion transmembrane transport (GO:1902600)3.12692810
58GTP biosynthetic process (GO:0006183)3.07767690
59cysteine metabolic process (GO:0006534)3.07440041
60negative regulation of epidermal cell differentiation (GO:0045605)3.05876689
61L-fucose catabolic process (GO:0042355)3.01955496
62fucose catabolic process (GO:0019317)3.01955496
63L-fucose metabolic process (GO:0042354)3.01955496
64regulation of immunoglobulin secretion (GO:0051023)2.98463015
65ventricular septum morphogenesis (GO:0060412)2.95949789
66ribonucleoside triphosphate biosynthetic process (GO:0009201)2.95467714
67microtubule depolymerization (GO:0007019)2.95011523
68regulation of female gonad development (GO:2000194)2.93533175
69proton transport (GO:0015992)2.89316151
70neuronal stem cell maintenance (GO:0097150)2.89067989
71intracellular protein transmembrane transport (GO:0065002)2.88579954
72nucleoside triphosphate biosynthetic process (GO:0009142)2.88562321
73hematopoietic stem cell proliferation (GO:0071425)2.87523937
74mannosylation (GO:0097502)2.87407322
75hydrogen transport (GO:0006818)2.84149307
76positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.83192841
77nuclear-transcribed mRNA catabolic process (GO:0000956)2.80062844
78protein transmembrane transport (GO:0071806)2.74392329
79negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.73249196
80negative regulation of cell aging (GO:0090344)2.71853127
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70649666
82G-protein coupled receptor internalization (GO:0002031)2.70408155
83DNA deamination (GO:0045006)2.70094650
84spinal cord association neuron differentiation (GO:0021527)2.69596161
85nucleoside diphosphate phosphorylation (GO:0006165)2.69318583
86mRNA catabolic process (GO:0006402)2.65433252
87nephron epithelium morphogenesis (GO:0072088)2.63774455
88nephron tubule morphogenesis (GO:0072078)2.63774455
89protein-cofactor linkage (GO:0018065)2.62401886
90lateral sprouting from an epithelium (GO:0060601)2.62351975
91epithelial cilium movement (GO:0003351)2.61657621
92spliceosomal snRNP assembly (GO:0000387)2.61052246
93cellular component biogenesis (GO:0044085)2.59020409
94kinetochore assembly (GO:0051382)2.58004917
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.57669014
96UTP biosynthetic process (GO:0006228)2.56909615
97regulation of oxidative phosphorylation (GO:0002082)2.55757609
98gamma-aminobutyric acid transport (GO:0015812)2.55028597
99neural tube formation (GO:0001841)2.55014712
100protein localization to cilium (GO:0061512)2.51775794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.98489027
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.26115517
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.16462753
4EZH2_22144423_ChIP-Seq_EOC_Human3.13075024
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.90638170
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79687217
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.69005960
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63211442
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61028782
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.42317982
11FUS_26573619_Chip-Seq_HEK293_Human2.38918584
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.34287578
13EWS_26573619_Chip-Seq_HEK293_Human2.33805917
14GBX2_23144817_ChIP-Seq_PC3_Human2.24279628
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22291360
16TAF15_26573619_Chip-Seq_HEK293_Human2.15599027
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13492907
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03757862
19VDR_22108803_ChIP-Seq_LS180_Human2.02233545
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.00780647
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91783422
22IGF1R_20145208_ChIP-Seq_DFB_Human1.89395005
23ZNF274_21170338_ChIP-Seq_K562_Hela1.86956801
24TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84666010
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.84666010
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.84151996
27P300_19829295_ChIP-Seq_ESCs_Human1.79618180
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74385391
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.73271888
30MYC_18940864_ChIP-ChIP_HL60_Human1.71097772
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.61972006
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54623761
33VDR_23849224_ChIP-Seq_CD4+_Human1.53723688
34ELK1_19687146_ChIP-ChIP_HELA_Human1.52904420
35RNF2_27304074_Chip-Seq_NSC_Mouse1.51830799
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50366518
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47591994
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.46420517
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44929947
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43563781
41TP53_22573176_ChIP-Seq_HFKS_Human1.42172185
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42051401
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41763419
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.40167475
45ER_23166858_ChIP-Seq_MCF-7_Human1.38182415
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35269077
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35174488
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32989659
49NANOG_19829295_ChIP-Seq_ESCs_Human1.31486054
50SOX2_19829295_ChIP-Seq_ESCs_Human1.31486054
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31308758
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29152821
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.28142676
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.27913525
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.23619284
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23397634
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20131225
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19975251
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19476299
60AR_25329375_ChIP-Seq_VCAP_Human1.17781009
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16774024
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16164522
63TTF2_22483619_ChIP-Seq_HELA_Human1.16043556
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14447077
65BCAT_22108803_ChIP-Seq_LS180_Human1.13062007
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11868145
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11284083
68CBP_20019798_ChIP-Seq_JUKART_Human1.11204727
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11204727
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10191078
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09807295
72IRF1_19129219_ChIP-ChIP_H3396_Human1.09334462
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08594537
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08510336
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06713942
76HTT_18923047_ChIP-ChIP_STHdh_Human1.05989712
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.05380308
78FOXP3_21729870_ChIP-Seq_TREG_Human1.04788942
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04588208
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02747706
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02279236
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01356259
83SMAD4_21741376_ChIP-Seq_EPCs_Human0.99911866
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98063674
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97382609
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96017305
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95943581
88TCF4_22108803_ChIP-Seq_LS180_Human0.95468959
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94894147
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93916269
91JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93681746
92AR_21572438_ChIP-Seq_LNCaP_Human0.93227905
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.92052681
94REST_21632747_ChIP-Seq_MESCs_Mouse0.91389283
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91017209
96SRF_21415370_ChIP-Seq_HL-1_Mouse0.90962420
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.88880884
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.88580373
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.87161842
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85835300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.74357917
2MP0003136_yellow_coat_color3.02706569
3MP0006072_abnormal_retinal_apoptosis2.97319941
4MP0006292_abnormal_olfactory_placode2.95022184
5MP0002138_abnormal_hepatobiliary_system2.93828172
6MP0010030_abnormal_orbit_morphology2.86796146
7MP0005253_abnormal_eye_physiology2.64047544
8MP0002938_white_spotting2.63441280
9MP0008875_abnormal_xenobiotic_pharmacok2.40310893
10MP0004142_abnormal_muscle_tone2.36710843
11MP0000372_irregular_coat_pigmentation2.16808505
12MP0004742_abnormal_vestibular_system2.09539167
13MP0005645_abnormal_hypothalamus_physiol2.08352169
14MP0005084_abnormal_gallbladder_morpholo2.06448993
15MP0003890_abnormal_embryonic-extraembry2.02121151
16MP0002736_abnormal_nociception_after1.92098513
17MP0000566_synostosis1.89160040
18MP0005646_abnormal_pituitary_gland1.70687850
19MP0005410_abnormal_fertilization1.70188466
20MP0001293_anophthalmia1.68288759
21MP0005551_abnormal_eye_electrophysiolog1.66452119
22MP0000569_abnormal_digit_pigmentation1.65304920
23MP0003195_calcinosis1.64128137
24MP0002095_abnormal_skin_pigmentation1.62776406
25MP0005394_taste/olfaction_phenotype1.60801119
26MP0005499_abnormal_olfactory_system1.60801119
27MP0002163_abnormal_gland_morphology1.60286426
28MP0005171_absent_coat_pigmentation1.53074935
29MP0005423_abnormal_somatic_nervous1.50667752
30MP0003806_abnormal_nucleotide_metabolis1.50062525
31MP0008789_abnormal_olfactory_epithelium1.47602792
32MP0005391_vision/eye_phenotype1.47508734
33MP0004133_heterotaxia1.43399908
34MP0006276_abnormal_autonomic_nervous1.42095850
35MP0002272_abnormal_nervous_system1.40999619
36MP0003011_delayed_dark_adaptation1.35109721
37MP0005167_abnormal_blood-brain_barrier1.34916555
38MP0003638_abnormal_response/metabolism_1.33838623
39MP0000631_abnormal_neuroendocrine_gland1.33362317
40MP0004885_abnormal_endolymph1.32164255
41MP0004215_abnormal_myocardial_fiber1.30019573
42MP0005671_abnormal_response_to1.28724957
43MP0001968_abnormal_touch/_nociception1.25604812
44MP0000778_abnormal_nervous_system1.25272715
45MP0008872_abnormal_physiological_respon1.23821645
46MP0005360_urolithiasis1.23794184
47MP0005197_abnormal_uvea_morphology1.23518604
48MP0005379_endocrine/exocrine_gland_phen1.23053651
49MP0001348_abnormal_lacrimal_gland1.22653682
50MP0001188_hyperpigmentation1.19784234
51MP0010368_abnormal_lymphatic_system1.17918535
52MP0002928_abnormal_bile_duct1.13384513
53MP0001529_abnormal_vocalization1.11182644
54MP0008057_abnormal_DNA_replication1.09980230
55MP0002735_abnormal_chemical_nociception1.07963470
56MP0003567_abnormal_fetal_cardiomyocyte1.07950120
57MP0009745_abnormal_behavioral_response1.06571838
58MP0001440_abnormal_grooming_behavior1.06392757
59MP0002234_abnormal_pharynx_morphology1.05381544
60MP0000026_abnormal_inner_ear1.05286561
61MP0009046_muscle_twitch1.03957424
62MP0001542_abnormal_bone_strength1.03870971
63MP0001879_abnormal_lymphatic_vessel1.02279147
64MP0002067_abnormal_sensory_capabilities1.02216992
65MP0005187_abnormal_penis_morphology1.01422946
66MP0001346_abnormal_lacrimal_gland1.01016373
67MP0002557_abnormal_social/conspecific_i0.97161533
68MP0005195_abnormal_posterior_eye0.97035857
69MP0002210_abnormal_sex_determination0.95880381
70MP0003937_abnormal_limbs/digits/tail_de0.94582309
71MP0001905_abnormal_dopamine_level0.92761418
72MP0000685_abnormal_immune_system0.90457893
73MP0002277_abnormal_respiratory_mucosa0.90096542
74MP0002697_abnormal_eye_size0.89016050
75MP0001984_abnormal_olfaction0.84033701
76MP0002653_abnormal_ependyma_morphology0.83872280
77MP0001286_abnormal_eye_development0.82859915
78MP0005408_hypopigmentation0.82546248
79MP0005595_abnormal_vascular_smooth0.82084786
80MP0004145_abnormal_muscle_electrophysio0.80929376
81MP0000049_abnormal_middle_ear0.80819541
82MP0001501_abnormal_sleep_pattern0.79403223
83MP0001873_stomach_inflammation0.77887650
84MP0005387_immune_system_phenotype0.76426415
85MP0001790_abnormal_immune_system0.76426415
86MP0003880_abnormal_central_pattern0.76023636
87MP0000955_abnormal_spinal_cord0.75131466
88MP0002572_abnormal_emotion/affect_behav0.75044361
89MP0008995_early_reproductive_senescence0.73900686
90MP0003122_maternal_imprinting0.73484398
91MP0003698_abnormal_male_reproductive0.73041912
92MP0001929_abnormal_gametogenesis0.71864660
93MP0002139_abnormal_hepatobiliary_system0.71716534
94MP0002752_abnormal_somatic_nervous0.70761309
95MP0002837_dystrophic_cardiac_calcinosis0.69766792
96MP0004019_abnormal_vitamin_homeostasis0.69619760
97MP0000653_abnormal_sex_gland0.69582459
98MP0001502_abnormal_circadian_rhythm0.69295216
99MP0006035_abnormal_mitochondrial_morpho0.68629164
100MP0005085_abnormal_gallbladder_physiolo0.67367911

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.29889671
2Abnormality of abdominal situs (HP:0011620)4.84032223
3Abdominal situs inversus (HP:0003363)4.84032223
4Acute necrotizing encephalopathy (HP:0006965)4.29111020
5Increased hepatocellular lipid droplets (HP:0006565)4.09906940
6Congenital, generalized hypertrichosis (HP:0004540)4.04727821
7Mitochondrial inheritance (HP:0001427)3.77438531
8Abnormal mitochondria in muscle tissue (HP:0008316)3.64651392
9Lipid accumulation in hepatocytes (HP:0006561)3.60048217
10Acute encephalopathy (HP:0006846)3.55806234
11Renal Fanconi syndrome (HP:0001994)3.53735567
12Abnormality of the pons (HP:0007361)3.45638466
13Stomatitis (HP:0010280)3.45499140
14Increased CSF lactate (HP:0002490)3.41891835
15Progressive macrocephaly (HP:0004481)3.38667973
16Hypoplasia of the pons (HP:0012110)3.34138070
17Reticulocytopenia (HP:0001896)3.32177327
18Pancreatic cysts (HP:0001737)3.17791989
19True hermaphroditism (HP:0010459)3.15017063
20Nephronophthisis (HP:0000090)3.10462244
21Sclerocornea (HP:0000647)3.08664918
22Hepatocellular necrosis (HP:0001404)3.06307392
23Macrocytic anemia (HP:0001972)2.95085132
24Abnormal sex determination (HP:0012244)2.92952474
25Sex reversal (HP:0012245)2.92952474
26Abnormal number of erythroid precursors (HP:0012131)2.85546259
27Exertional dyspnea (HP:0002875)2.75526744
28Abnormality of cells of the erythroid lineage (HP:0012130)2.69157582
29Aplasia/hypoplasia of the uterus (HP:0008684)2.62770379
30Abnormal drinking behavior (HP:0030082)2.61001303
31Polydipsia (HP:0001959)2.61001303
32Abnormality of midbrain morphology (HP:0002418)2.57705190
33Molar tooth sign on MRI (HP:0002419)2.57705190
34Septo-optic dysplasia (HP:0100842)2.56182790
35Hepatic necrosis (HP:0002605)2.52410944
36Abnormality of the renal medulla (HP:0100957)2.49413329
37Colon cancer (HP:0003003)2.46043822
38Cerebral edema (HP:0002181)2.44170589
39Abnormality of renal resorption (HP:0011038)2.35461364
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32952799
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32952799
42Rib fusion (HP:0000902)2.32474937
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.31896481
44Delayed CNS myelination (HP:0002188)2.31073307
45Increased intramyocellular lipid droplets (HP:0012240)2.29792330
46Absent septum pellucidum (HP:0001331)2.29592113
47Tubular atrophy (HP:0000092)2.25367526
48Abnormality of the labia minora (HP:0012880)2.24561082
49Methylmalonic acidemia (HP:0002912)2.18760991
50Increased IgM level (HP:0003496)2.18238259
51Supernumerary bones of the axial skeleton (HP:0009144)2.16659473
52Pancreatic fibrosis (HP:0100732)2.14708349
53Abnormality of the renal cortex (HP:0011035)2.12995218
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11411207
55Optic disc pallor (HP:0000543)2.10346374
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.09466684
57Type I transferrin isoform profile (HP:0003642)2.08918305
58Leukodystrophy (HP:0002415)2.07998300
593-Methylglutaconic aciduria (HP:0003535)2.07799550
60Methylmalonic aciduria (HP:0012120)2.07790584
61Abnormal rod and cone electroretinograms (HP:0008323)2.05993838
62High anterior hairline (HP:0009890)2.04774647
63Abnormality of placental membranes (HP:0011409)2.00241314
64Amniotic constriction ring (HP:0009775)2.00241314
65Abnormality of urine glucose concentration (HP:0011016)1.99814419
66Glycosuria (HP:0003076)1.99814419
67Supernumerary ribs (HP:0005815)1.94481129
68Abnormality of the septum pellucidum (HP:0007375)1.94434785
69Abnormal biliary tract physiology (HP:0012439)1.89665315
70Bile duct proliferation (HP:0001408)1.89665315
71Polyuria (HP:0000103)1.88960361
72Increased serum lactate (HP:0002151)1.87158393
73Pallor (HP:0000980)1.84208101
74Limb dystonia (HP:0002451)1.83453666
75Large for gestational age (HP:0001520)1.80058221
76Lactic acidosis (HP:0003128)1.79924081
77Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79655809
78Growth hormone deficiency (HP:0000824)1.79398274
79Arthropathy (HP:0003040)1.79308235
80Male pseudohermaphroditism (HP:0000037)1.78533562
81Respiratory failure (HP:0002878)1.78461044
82Abnormality of secondary sexual hair (HP:0009888)1.78389152
83Abnormality of the axillary hair (HP:0100134)1.78389152
84Hyperphosphaturia (HP:0003109)1.77757496
85Poor head control (HP:0002421)1.77636918
86Pancytopenia (HP:0001876)1.75405606
87Increased muscle lipid content (HP:0009058)1.74316667
88Hyperglycinemia (HP:0002154)1.73567788
89Chronic sinusitis (HP:0011109)1.72993234
90Duplicated collecting system (HP:0000081)1.71771300
91Congenital hepatic fibrosis (HP:0002612)1.71648499
92Aplastic anemia (HP:0001915)1.70830224
93Medial flaring of the eyebrow (HP:0010747)1.69956003
94Preaxial hand polydactyly (HP:0001177)1.69036860
952-3 toe syndactyly (HP:0004691)1.68648957
96Anencephaly (HP:0002323)1.68641786
97Exercise intolerance (HP:0003546)1.67688185
98Decreased central vision (HP:0007663)1.67603965
99IgG deficiency (HP:0004315)1.66408901
100Skull defect (HP:0001362)1.65050849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK14.24125140
2PNCK3.29584218
3VRK23.14300951
4MAP3K122.80982170
5NME12.79529411
6VRK12.67886582
7WNK32.65568823
8WNK42.64130355
9TSSK62.41313171
10STK392.15752274
11ZAK2.14455047
12TLK12.09900615
13SRPK11.97982668
14DYRK21.97616370
15NUAK11.87401518
16TXK1.84984273
17TAOK31.77134822
18WEE11.73113704
19TAF11.70999030
20BUB11.66880777
21KIT1.61602867
22MAPK151.54689499
23TGFBR11.49182012
24CDC71.47897369
25ADRBK21.47198030
26PASK1.41690653
27EIF2AK21.40480708
28MST41.29806076
29PLK31.29480828
30NEK11.28767893
31MKNK21.28363949
32MKNK11.22112096
33PBK1.21930940
34MAPK131.17986652
35EPHA41.11138341
36OBSCN1.10990420
37MAP4K21.02495907
38CDK30.95498073
39OXSR10.93145663
40CSNK1G20.93112357
41FES0.91588309
42PRKCG0.91283206
43IKBKB0.90752276
44NTRK20.89858970
45MARK10.86985448
46PLK40.86716832
47TIE10.85564365
48CSNK1G10.83835278
49TNIK0.83506357
50PINK10.82696704
51INSRR0.82093940
52BMPR1B0.80551486
53MAP3K40.79506783
54MAPKAPK50.79166060
55SGK4940.78968127
56SGK2230.78968127
57EIF2AK30.76229183
58PLK20.76066295
59BCKDK0.74052977
60SGK20.72340132
61PIK3CA0.71971538
62SIK20.71450847
63CSNK1G30.70668592
64PHKG20.68765611
65PHKG10.68765611
66FGFR20.68240058
67CAMK2A0.66785534
68EPHB20.65311064
69CSNK1A10.63564184
70BCR0.60988543
71PRKCQ0.60870152
72CSNK1A1L0.60097578
73PTK2B0.60020797
74CCNB10.57297098
75PRKACA0.55906274
76PIK3CG0.55027425
77MAP2K40.54677027
78AURKA0.53452049
79MAP2K70.52566973
80PRKG10.51752755
81SYK0.51436436
82GRK50.50565214
83PRKACG0.49857321
84RPS6KA50.48311183
85STK38L0.46026050
86PRKCE0.45814516
87AKT30.44073014
88CAMK10.43386337
89CSNK2A20.40272468
90STK30.38091300
91MAP3K110.37326566
92CSNK2A10.37140287
93PKN10.37081963
94ADRBK10.36687086
95PRKACB0.35669924
96FGFR10.35106449
97IKBKE0.35083882
98STK160.34481826
99PAK30.34220016
100DYRK30.33913569

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.80090867
2Oxidative phosphorylation_Homo sapiens_hsa001904.44905102
3Parkinsons disease_Homo sapiens_hsa050123.73357857
4Proteasome_Homo sapiens_hsa030503.24286741
5Huntingtons disease_Homo sapiens_hsa050162.62175436
6Alzheimers disease_Homo sapiens_hsa050102.61596286
7Protein export_Homo sapiens_hsa030602.58373493
8Phototransduction_Homo sapiens_hsa047442.34818638
9Asthma_Homo sapiens_hsa053102.33181119
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.16918334
11Cardiac muscle contraction_Homo sapiens_hsa042601.97583984
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.91767052
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90098456
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76350772
15RNA polymerase_Homo sapiens_hsa030201.70066677
16Allograft rejection_Homo sapiens_hsa053301.67851989
17Autoimmune thyroid disease_Homo sapiens_hsa053201.64593480
18Systemic lupus erythematosus_Homo sapiens_hsa053221.63525068
19Mismatch repair_Homo sapiens_hsa034301.59134911
20Steroid biosynthesis_Homo sapiens_hsa001001.51451004
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49160497
22One carbon pool by folate_Homo sapiens_hsa006701.47244305
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43911209
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42978552
25Nicotine addiction_Homo sapiens_hsa050331.39233714
26Caffeine metabolism_Homo sapiens_hsa002321.38855399
27Homologous recombination_Homo sapiens_hsa034401.32621969
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.26370807
29DNA replication_Homo sapiens_hsa030301.20494623
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20347374
31Folate biosynthesis_Homo sapiens_hsa007901.17915848
32Primary immunodeficiency_Homo sapiens_hsa053401.17737901
33Fanconi anemia pathway_Homo sapiens_hsa034601.15869102
34RNA degradation_Homo sapiens_hsa030181.15164321
35RNA transport_Homo sapiens_hsa030131.13060748
36Spliceosome_Homo sapiens_hsa030401.08971215
37Peroxisome_Homo sapiens_hsa041461.08494780
38Sulfur relay system_Homo sapiens_hsa041221.03603169
39Butanoate metabolism_Homo sapiens_hsa006500.97421136
40Linoleic acid metabolism_Homo sapiens_hsa005910.96272216
41Retinol metabolism_Homo sapiens_hsa008300.90075358
42Nitrogen metabolism_Homo sapiens_hsa009100.89011110
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.88028705
44Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86656641
45Basal cell carcinoma_Homo sapiens_hsa052170.85458315
46Hedgehog signaling pathway_Homo sapiens_hsa043400.84239331
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83441060
48Type I diabetes mellitus_Homo sapiens_hsa049400.82704567
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.82552184
50Purine metabolism_Homo sapiens_hsa002300.81769045
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80704112
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.80019168
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79202848
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75576048
55Nucleotide excision repair_Homo sapiens_hsa034200.74371442
56Alcoholism_Homo sapiens_hsa050340.72775978
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72747921
58Chemical carcinogenesis_Homo sapiens_hsa052040.72483702
59Ether lipid metabolism_Homo sapiens_hsa005650.70672414
60Regulation of autophagy_Homo sapiens_hsa041400.69749243
61Pyrimidine metabolism_Homo sapiens_hsa002400.69514959
62Vitamin digestion and absorption_Homo sapiens_hsa049770.67202872
63Metabolic pathways_Homo sapiens_hsa011000.66750040
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66538064
65Graft-versus-host disease_Homo sapiens_hsa053320.66030198
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62352923
67Morphine addiction_Homo sapiens_hsa050320.60374351
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58687158
69Collecting duct acid secretion_Homo sapiens_hsa049660.58371788
70Propanoate metabolism_Homo sapiens_hsa006400.56340228
71Glutathione metabolism_Homo sapiens_hsa004800.55593494
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54162999
73GABAergic synapse_Homo sapiens_hsa047270.51426926
74Basal transcription factors_Homo sapiens_hsa030220.51084396
75Tryptophan metabolism_Homo sapiens_hsa003800.51054199
76Olfactory transduction_Homo sapiens_hsa047400.50158696
77Rheumatoid arthritis_Homo sapiens_hsa053230.49472687
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47912345
79Antigen processing and presentation_Homo sapiens_hsa046120.46234234
80Taste transduction_Homo sapiens_hsa047420.44941839
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.43721817
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43527775
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41698399
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41005648
85Circadian entrainment_Homo sapiens_hsa047130.40477945
86Hematopoietic cell lineage_Homo sapiens_hsa046400.40400593
87Cocaine addiction_Homo sapiens_hsa050300.40088616
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38971094
89Salivary secretion_Homo sapiens_hsa049700.38370633
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36890513
91Non-homologous end-joining_Homo sapiens_hsa034500.34092459
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30811238
93Mineral absorption_Homo sapiens_hsa049780.29586030
94Glutamatergic synapse_Homo sapiens_hsa047240.29397576
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27995361
96Arachidonic acid metabolism_Homo sapiens_hsa005900.27785134
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25800661
98beta-Alanine metabolism_Homo sapiens_hsa004100.25338942
99Serotonergic synapse_Homo sapiens_hsa047260.24530057
100Insulin secretion_Homo sapiens_hsa049110.24278117

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