RBMS1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.33534984
2response to peptidoglycan (GO:0032494)6.30079986
3modulation by symbiont of host immune response (GO:0052553)5.84273624
4positive regulation by symbiont of host defense response (GO:0052509)5.84273624
5modulation by symbiont of host defense response (GO:0052031)5.84273624
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.84273624
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.84273624
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.84273624
9positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.45860127
10detection of molecule of bacterial origin (GO:0032490)5.43202240
11cellular extravasation (GO:0045123)5.22516802
12negative regulation of interleukin-12 production (GO:0032695)5.16970654
13neutrophil activation involved in immune response (GO:0002283)4.95928205
14macrophage activation involved in immune response (GO:0002281)4.82910805
15microglial cell activation (GO:0001774)4.78211426
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.58819033
17negative regulation of cell killing (GO:0031342)4.58819033
18regulation of gamma-delta T cell activation (GO:0046643)4.55494994
19regulation of B cell receptor signaling pathway (GO:0050855)4.55105756
20neutrophil mediated immunity (GO:0002446)4.44906582
21detection of other organism (GO:0098543)4.23797260
22macrophage activation (GO:0042116)4.23440268
23positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.22227729
24regulation of interferon-beta biosynthetic process (GO:0045357)4.19660749
25neutrophil activation (GO:0042119)4.19537780
26response to host immune response (GO:0052572)4.18247132
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.18247132
28detection of external biotic stimulus (GO:0098581)4.13657951
29response to muramyl dipeptide (GO:0032495)4.01747512
30response to host (GO:0075136)3.95228287
31response to host defenses (GO:0052200)3.95228287
32response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.95228287
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.91406170
34regulation of gamma-delta T cell differentiation (GO:0045586)3.89236997
35detection of biotic stimulus (GO:0009595)3.83926422
36positive regulation of mast cell activation (GO:0033005)3.82253496
37regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.73123975
38respiratory burst (GO:0045730)3.71850059
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.71775723
40granulocyte activation (GO:0036230)3.70531432
41myeloid leukocyte mediated immunity (GO:0002444)3.67324486
42regulation of mast cell degranulation (GO:0043304)3.64150311
43regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.62884710
44leukocyte aggregation (GO:0070486)3.55871736
45regulation of macrophage cytokine production (GO:0010935)3.55700132
46T-helper 1 type immune response (GO:0042088)3.54293139
47negative regulation of T cell mediated immunity (GO:0002710)3.53550793
48detection of bacterium (GO:0016045)3.51128646
49sequestering of actin monomers (GO:0042989)3.49770724
50regulation of mast cell activation (GO:0033003)3.44894302
51myeloid cell activation involved in immune response (GO:0002275)3.44611823
52energy homeostasis (GO:0097009)3.43463855
53positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.41508370
54regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.41384167
55lipopolysaccharide-mediated signaling pathway (GO:0031663)3.40252766
56negative regulation of interleukin-6 production (GO:0032715)3.36471026
57leukocyte migration involved in inflammatory response (GO:0002523)3.34636725
58regulation of mast cell activation involved in immune response (GO:0033006)3.34396765
59negative regulation of lymphocyte mediated immunity (GO:0002707)3.33466571
60positive regulation of mast cell activation involved in immune response (GO:0033008)3.33411154
61positive regulation of mast cell degranulation (GO:0043306)3.33411154
62regulation of interleukin-12 biosynthetic process (GO:0045075)3.32783438
63regulation of myeloid leukocyte mediated immunity (GO:0002886)3.30749374
64production of molecular mediator involved in inflammatory response (GO:0002532)3.29902335
65neutrophil chemotaxis (GO:0030593)3.27242613
66positive thymic T cell selection (GO:0045059)3.22657621
67regulation of interleukin-6 biosynthetic process (GO:0045408)3.20524809
68neutrophil migration (GO:1990266)3.19416361
69defense response to protozoan (GO:0042832)3.18170054
70B cell receptor signaling pathway (GO:0050853)3.17120027
71positive regulation of tolerance induction (GO:0002645)3.11243209
72positive regulation of toll-like receptor signaling pathway (GO:0034123)3.09556264
73germinal center formation (GO:0002467)3.06374132
74regulation of leukocyte degranulation (GO:0043300)3.05547944
75regulation of tolerance induction (GO:0002643)3.03710476
76negative thymic T cell selection (GO:0045060)3.03624233
77regulation of interleukin-8 biosynthetic process (GO:0045414)3.03499930
78regulation of B cell differentiation (GO:0045577)3.03233258
79negative regulation of interleukin-1 production (GO:0032692)3.00106099
80tolerance induction (GO:0002507)2.98978469
81superoxide anion generation (GO:0042554)2.98613613
82activated T cell proliferation (GO:0050798)2.98195730
83dopaminergic neuron differentiation (GO:0071542)2.98172957
84positive regulation of interferon-alpha production (GO:0032727)2.97792935
85antigen processing and presentation of endogenous antigen (GO:0019883)2.95757516
86interferon-gamma production (GO:0032609)2.94655030
87immunoglobulin mediated immune response (GO:0016064)2.94463601
88positive regulation of B cell differentiation (GO:0045579)2.92983949
89negative regulation of interleukin-1 beta production (GO:0032691)2.92205806
90negative T cell selection (GO:0043383)2.89913406
91negative regulation of toll-like receptor signaling pathway (GO:0034122)2.88754353
92regulation of dendritic cell antigen processing and presentation (GO:0002604)2.88596793
93negative regulation of leukocyte mediated immunity (GO:0002704)2.88409520
94response to protozoan (GO:0001562)2.86832962
95negative regulation of interleukin-17 production (GO:0032700)2.84356123
96myeloid leukocyte activation (GO:0002274)2.82871349
97dendritic cell migration (GO:0036336)2.80975947
98positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.80124135
99regulation of toll-like receptor signaling pathway (GO:0034121)2.79693825
100negative regulation of erythrocyte differentiation (GO:0045647)2.78496585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.67566038
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.31169559
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.11851197
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.10833338
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.91141608
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.32803068
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.24388956
8RUNX_20019798_ChIP-Seq_JUKART_Human3.23355020
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20780231
10SCL_19346495_ChIP-Seq_HPC-7_Human3.08434649
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.84396366
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.77558796
13VDR_24787735_ChIP-Seq_THP-1_Human2.72780280
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.68974568
15VDR_24763502_ChIP-Seq_THP-1_Human2.58923277
16GATA1_22025678_ChIP-Seq_K562_Human2.57147658
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51195006
18SPI1_23127762_ChIP-Seq_K562_Human2.44692770
19SPI1_23547873_ChIP-Seq_NB4_Human2.32800749
20PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.29947270
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28439974
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27909969
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22985096
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11056663
25VDR_21846776_ChIP-Seq_THP-1_Human2.07090896
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04752820
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92078461
28MYB_26560356_Chip-Seq_TH2_Human1.86496168
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.83540142
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.81629500
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74704247
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74629417
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.69134217
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61752694
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61070994
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59872429
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56510597
38GATA3_26560356_Chip-Seq_TH2_Human1.49443865
39MAF_26560356_Chip-Seq_TH1_Human1.48521293
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43361927
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41662238
42GATA3_27048872_Chip-Seq_THYMUS_Human1.40343991
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40089869
44MYB_26560356_Chip-Seq_TH1_Human1.36869439
45GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34433985
46PU_27001747_Chip-Seq_BMDM_Mouse1.34277554
47UTX_26944678_Chip-Seq_JUKART_Human1.32420139
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28327087
49SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28039866
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26484505
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26317472
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.26258856
53TCF7_22412390_ChIP-Seq_EML_Mouse1.25135836
54GATA1_19941826_ChIP-Seq_K562_Human1.24588154
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22792856
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21216471
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17218348
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16424001
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13833958
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11054780
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10653503
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09175010
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08841547
64TAF15_26573619_Chip-Seq_HEK293_Human1.06771640
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06574386
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06574386
67GATA2_19941826_ChIP-Seq_K562_Human1.05935151
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01163060
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97222009
70KDM2B_26808549_Chip-Seq_JURKAT_Human0.96597237
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95943854
72EGR1_19032775_ChIP-ChIP_M12_Human0.95567802
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94961372
74MAF_26560356_Chip-Seq_TH2_Human0.90290950
75FLI1_27457419_Chip-Seq_LIVER_Mouse0.89137455
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87374906
77PRDM14_20953172_ChIP-Seq_ESCs_Human0.87023887
78KDM2B_26808549_Chip-Seq_DND41_Human0.85936778
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83594660
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83466819
81ER_23166858_ChIP-Seq_MCF-7_Human0.83394096
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83372201
83GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81815731
84FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81020369
85CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79978904
86SMRT_27268052_Chip-Seq_Bcells_Human0.79456740
87STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78542757
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77804479
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75953354
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75388554
91BCAT_22108803_ChIP-Seq_LS180_Human0.75222452
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74751029
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74221300
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.73678326
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.73033991
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72246202
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71575796
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.69713598
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.69192052
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.69133879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.95119060
2MP0000569_abnormal_digit_pigmentation4.93532176
3MP0003303_peritoneal_inflammation4.12128243
4MP0003436_decreased_susceptibility_to3.66072186
5MP0001835_abnormal_antigen_presentation3.47030231
6MP0003828_pulmonary_edema3.12953087
7MP0002419_abnormal_innate_immunity3.01634176
8MP0001800_abnormal_humoral_immune2.63874451
9MP0005025_abnormal_response_to2.50802795
10MP0009785_altered_susceptibility_to2.46100902
11MP0005000_abnormal_immune_tolerance2.40497708
12MP0005671_abnormal_response_to2.37638498
13MP0002723_abnormal_immune_serum2.35091008
14MP0000685_abnormal_immune_system2.34468276
15MP0002452_abnormal_antigen_presenting2.32427144
16MP0003300_gastrointestinal_ulcer2.27019273
17MP0002420_abnormal_adaptive_immunity2.21705042
18MP0001819_abnormal_immune_cell2.19313161
19MP0002132_abnormal_respiratory_system2.08762057
20MP0002148_abnormal_hypersensitivity_rea2.06281817
21MP0004381_abnormal_hair_follicle2.01096850
22MP0004883_abnormal_blood_vessel2.00732761
23MP0009764_decreased_sensitivity_to1.97903613
24MP0005387_immune_system_phenotype1.91067628
25MP0001790_abnormal_immune_system1.91067628
26MP0001533_abnormal_skeleton_physiology1.84567500
27MP0003172_abnormal_lysosome_physiology1.79546344
28MP0009278_abnormal_bone_marrow1.76869769
29MP0008260_abnormal_autophagy1.76479887
30MP0002405_respiratory_system_inflammati1.73388496
31MP0001346_abnormal_lacrimal_gland1.70936383
32MP0000716_abnormal_immune_system1.67697586
33MP0002398_abnormal_bone_marrow1.60011773
34MP0004808_abnormal_hematopoietic_stem1.57706425
35MP0003656_abnormal_erythrocyte_physiolo1.55736154
36MP0002277_abnormal_respiratory_mucosa1.54469396
37MP0005464_abnormal_platelet_physiology1.52797563
38MP0003191_abnormal_cellular_cholesterol1.51788093
39MP0001845_abnormal_inflammatory_respons1.49528776
40MP0005164_abnormal_response_to1.49190829
41MP0006082_CNS_inflammation1.45817494
42MP0002396_abnormal_hematopoietic_system1.44294794
43MP0000604_amyloidosis1.43927804
44MP0003763_abnormal_thymus_physiology1.42662453
45MP0000465_gastrointestinal_hemorrhage1.39510435
46MP0003329_amyloid_beta_deposits1.37423503
47MP0010155_abnormal_intestine_physiology1.35770126
48MP0002166_altered_tumor_susceptibility1.35276183
49MP0004947_skin_inflammation1.30738977
50MP0003646_muscle_fatigue1.30467191
51MP0000689_abnormal_spleen_morphology1.28727474
52MP0001853_heart_inflammation1.28615244
53MP0002653_abnormal_ependyma_morphology1.27216937
54MP0002722_abnormal_immune_system1.26804749
55MP0002429_abnormal_blood_cell1.23731508
56MP0003075_altered_response_to1.22859774
57MP0008469_abnormal_protein_level1.18567611
58MP0005075_abnormal_melanosome_morpholog1.17719782
59MP0005310_abnormal_salivary_gland1.14870358
60MP0005397_hematopoietic_system_phenotyp1.12923831
61MP0001545_abnormal_hematopoietic_system1.12923831
62MP0002009_preneoplasia1.11767830
63MP0002998_abnormal_bone_remodeling1.11420510
64MP0000343_altered_response_to1.10884780
65MP0001851_eye_inflammation1.10285192
66MP0000703_abnormal_thymus_morphology1.08962255
67MP0000858_altered_metastatic_potential1.08177885
68MP0000015_abnormal_ear_pigmentation1.08026119
69MP0002006_tumorigenesis1.00464373
70MP0005174_abnormal_tail_pigmentation0.97124989
71MP0004130_abnormal_muscle_cell0.96513436
72MP0008004_abnormal_stomach_pH0.93463814
73MP0001324_abnormal_eye_pigmentation0.93281107
74MP0003866_abnormal_defecation0.93110634
75MP0002735_abnormal_chemical_nociception0.88871230
76MP0005167_abnormal_blood-brain_barrier0.85818669
77MP0001905_abnormal_dopamine_level0.85262039
78MP0005390_skeleton_phenotype0.84818385
79MP0002332_abnormal_exercise_endurance0.84481070
80MP0003448_altered_tumor_morphology0.83197427
81MP0005084_abnormal_gallbladder_morpholo0.82952903
82MP0001663_abnormal_digestive_system0.77846873
83MP0003091_abnormal_cell_migration0.75771783
84MP0005076_abnormal_cell_differentiation0.75651892
85MP0002928_abnormal_bile_duct0.73891564
86MP0009765_abnormal_xenobiotic_induced0.72533524
87MP0003787_abnormal_imprinting0.71055576
88MP0002138_abnormal_hepatobiliary_system0.70363274
89MP0000249_abnormal_blood_vessel0.70071789
90MP0005166_decreased_susceptibility_to0.67042974
91MP0008057_abnormal_DNA_replication0.65032328
92MP0005451_abnormal_body_composition0.63807947
93MP0005388_respiratory_system_phenotype0.63643678
94MP0002133_abnormal_respiratory_system0.63643678
95MP0005376_homeostasis/metabolism_phenot0.63234958
96MP0002933_joint_inflammation0.63074313
97MP0003690_abnormal_glial_cell0.62796086
98MP0005535_abnormal_body_temperature0.62753257
99MP0003632_abnormal_nervous_system0.58926208
100MP0001186_pigmentation_phenotype0.57790651

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.04890378
2Recurrent abscess formation (HP:0002722)5.52803392
3Myositis (HP:0100614)5.37073967
4Eczematoid dermatitis (HP:0000976)5.27946098
5Stomatitis (HP:0010280)5.22570781
6Optic neuritis (HP:0100653)5.18613726
7Retrobulbar optic neuritis (HP:0100654)5.18613726
8Orchitis (HP:0100796)5.05659968
9Recurrent gram-negative bacterial infections (HP:0005420)5.01108318
10Elevated erythrocyte sedimentation rate (HP:0003565)4.87512974
11Recurrent skin infections (HP:0001581)4.33681995
12Gastrointestinal infarctions (HP:0005244)4.15002113
13Abnormality of macrophages (HP:0004311)4.11825070
14Chronic mucocutaneous candidiasis (HP:0002728)3.97829213
15Recurrent cutaneous fungal infections (HP:0011370)3.97829213
16Recurrent fungal infections (HP:0002841)3.93929673
17Encephalitis (HP:0002383)3.76998326
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.70557199
19Stomach cancer (HP:0012126)3.66487844
20Keratoconjunctivitis sicca (HP:0001097)3.65069746
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.43545273
22Viral hepatitis (HP:0006562)3.38195115
23Keratoconjunctivitis (HP:0001096)3.34413970
24Arterial thrombosis (HP:0004420)3.22545604
25Peritonitis (HP:0002586)3.15812338
26Subacute progressive viral hepatitis (HP:0006572)3.15372415
27Vasculitis (HP:0002633)3.12635353
28Mediastinal lymphadenopathy (HP:0100721)3.05027428
29Meningitis (HP:0001287)3.03453811
30Gingival bleeding (HP:0000225)3.03177482
31Episodic fever (HP:0001954)2.96387000
32Amyloidosis (HP:0011034)2.84585180
33T lymphocytopenia (HP:0005403)2.80943069
34Anterior segment dysgenesis (HP:0007700)2.80697722
35Leukocytosis (HP:0001974)2.79895218
36Obstructive lung disease (HP:0006536)2.77515639
37Chronic obstructive pulmonary disease (HP:0006510)2.77515639
38Chest pain (HP:0100749)2.76134067
39Gingivitis (HP:0000230)2.71802167
40Abnormality of T cell number (HP:0011839)2.71719077
41Prolonged bleeding time (HP:0003010)2.67113828
42Hemoptysis (HP:0002105)2.64925671
43Polyphagia (HP:0002591)2.56506567
44Pulmonary infiltrates (HP:0002113)2.53956451
45Neoplasm of the tracheobronchial system (HP:0100552)2.53435285
46Alveolar cell carcinoma (HP:0006519)2.50680368
47Recurrent viral infections (HP:0004429)2.49839997
48Gangrene (HP:0100758)2.49346500
49Vertigo (HP:0002321)2.48015661
50Colitis (HP:0002583)2.45630492
51Epistaxis (HP:0000421)2.45076697
52Urticaria (HP:0001025)2.42422504
53Panhypogammaglobulinemia (HP:0003139)2.40364439
54Cellulitis (HP:0100658)2.35925885
55Spontaneous hematomas (HP:0007420)2.35674368
56Abnormality of T cells (HP:0002843)2.33741257
57Chronic otitis media (HP:0000389)2.32996956
58Inflammation of the large intestine (HP:0002037)2.32326467
59Increased IgE level (HP:0003212)2.27022376
60Supernumerary ribs (HP:0005815)2.25929004
61Acute lymphatic leukemia (HP:0006721)2.25739193
62Anorexia (HP:0002039)2.25462086
63IgM deficiency (HP:0002850)2.20171731
64Abnormal drinking behavior (HP:0030082)2.18893848
65Polydipsia (HP:0001959)2.18893848
66Supernumerary bones of the axial skeleton (HP:0009144)2.18850261
67Abnormality of the peritoneum (HP:0002585)2.18382288
68Pulmonary embolism (HP:0002204)2.14685384
69Slow saccadic eye movements (HP:0000514)2.11962136
70Gastrointestinal inflammation (HP:0004386)2.10181722
71Thrombocytosis (HP:0001894)2.07457445
72Recurrent bronchitis (HP:0002837)2.01785616
73Amaurosis fugax (HP:0100576)2.00425597
74Muscle fiber splitting (HP:0003555)1.96096376
75Exertional dyspnea (HP:0002875)1.92467585
76Micronodular cirrhosis (HP:0001413)1.91797702
77Abnormality of the pleura (HP:0002103)1.90704057
78Increased IgM level (HP:0003496)1.89342269
79Abnormality of T cell physiology (HP:0011840)1.87529835
80Acute myeloid leukemia (HP:0004808)1.85488952
81Polyneuropathy (HP:0001271)1.84764954
82Glomerulopathy (HP:0100820)1.84405509
83Chronic sinusitis (HP:0011109)1.84152422
84Widely spaced teeth (HP:0000687)1.84003668
85Abnormality of the parietal bone (HP:0002696)1.83026456
86Respiratory difficulties (HP:0002880)1.81406535
87Pustule (HP:0200039)1.81074691
88Abnormality of the endocardium (HP:0004306)1.77669680
89Agammaglobulinemia (HP:0004432)1.74458633
90Osteomyelitis (HP:0002754)1.73036545
91Concave nail (HP:0001598)1.72500334
92Abnormality of liposaccharide metabolism (HP:0010968)1.71486022
93Abnormality of glycosphingolipid metabolism (HP:0004343)1.71486022
94Abnormality of glycolipid metabolism (HP:0010969)1.71486022
95Granulocytopenia (HP:0001913)1.68116108
96Xerostomia (HP:0000217)1.67511795
97Eosinophilia (HP:0001880)1.63633141
98Short 4th metacarpal (HP:0010044)1.63120759
99Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63120759
100Segmental peripheral demyelination/remyelination (HP:0003481)1.62710897

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.78686364
2IRAK43.51013507
3TAOK33.31639544
4BLK2.81592756
5MAP2K32.59537989
6MAP4K12.56816888
7MAP3K142.53157098
8CSK2.41836927
9FES2.37008840
10IRAK12.35024182
11TXK2.30251667
12TYK22.28502323
13MAP3K132.21430630
14IKBKE2.10969099
15FGR2.06574670
16GRK62.06561563
17IRAK22.05043773
18ZAP701.80980638
19SYK1.71626150
20JAK31.66506359
21KIT1.63713549
22TBK11.61063672
23IRAK31.53806133
24BTK1.51652106
25MATK1.49419165
26IKBKB1.48974438
27TEC1.47862025
28CSF1R1.47108522
29HCK1.45242702
30BMPR21.41060303
31JAK11.37469716
32TLK11.26115250
33MAP3K31.25123272
34WNK11.18272184
35LYN1.17112133
36PRPF4B1.14037583
37JAK21.11306110
38MARK31.09040902
39MAP2K41.08200287
40MAP3K11.07539219
41KSR21.06938834
42SIK11.06522315
43CHUK1.04446266
44LRRK21.03439235
45LCK1.03242247
46ITK1.01879293
47MAP3K21.00804763
48EPHB10.99168324
49SIK30.96533952
50PIK3CG0.96406411
51TNK20.96190087
52MARK20.94830952
53MAP3K110.94011381
54MAP3K70.93525645
55GRK70.89894376
56PINK10.87536659
57YES10.82630773
58EPHA30.82566455
59PTK2B0.74898467
60MAP2K60.74497411
61MAPK70.68824769
62MAP3K60.66391541
63PIM10.64497644
64CDK190.62833945
65FGFR30.62435249
66SIK20.59418981
67NME10.58152094
68NLK0.57939004
69MAPK120.57788323
70SGK20.56414133
71RAF10.55564565
72PDK10.53725949
73FRK0.52872825
74FYN0.52637163
75CDK80.52039288
76MAPK40.51120362
77DYRK30.50460204
78DYRK1A0.50364262
79PASK0.50021962
80KSR10.49009721
81TAOK10.47930502
82ERN10.47081659
83SGK30.42800256
84DAPK20.41439149
85CAMK1D0.39823020
86PDPK10.39644724
87RET0.39314752
88MAP3K50.39014161
89CAMK1G0.38997183
90CDK120.38723132
91HIPK20.36740465
92SGK10.36520519
93ABL10.35007530
94PRKCQ0.34481959
95DYRK1B0.33155072
96ADRBK10.32849669
97STK110.31423508
98PNCK0.29361110
99MOS0.29323362
100RPS6KA60.29219754

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.09162242
2Osteoclast differentiation_Homo sapiens_hsa043802.90986452
3NOD-like receptor signaling pathway_Homo sapiens_hsa046212.68834597
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31912934
5B cell receptor signaling pathway_Homo sapiens_hsa046622.23228651
6Staphylococcus aureus infection_Homo sapiens_hsa051502.18594773
7Tuberculosis_Homo sapiens_hsa051522.15576657
8Legionellosis_Homo sapiens_hsa051342.03103240
9Malaria_Homo sapiens_hsa051442.01552001
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.91902193
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.88153951
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87076445
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75223200
14Acute myeloid leukemia_Homo sapiens_hsa052211.71423909
15TNF signaling pathway_Homo sapiens_hsa046681.70004626
16T cell receptor signaling pathway_Homo sapiens_hsa046601.68643651
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64582908
18Chemokine signaling pathway_Homo sapiens_hsa040621.62554573
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.58647803
20Measles_Homo sapiens_hsa051621.56028837
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52258186
22Dorso-ventral axis formation_Homo sapiens_hsa043201.50944627
23Toxoplasmosis_Homo sapiens_hsa051451.47596425
24Influenza A_Homo sapiens_hsa051641.44567429
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.42028576
26Hematopoietic cell lineage_Homo sapiens_hsa046401.39951399
27Hepatitis B_Homo sapiens_hsa051611.37554630
28Renal cell carcinoma_Homo sapiens_hsa052111.36909442
29Primary immunodeficiency_Homo sapiens_hsa053401.33537702
30Graft-versus-host disease_Homo sapiens_hsa053321.31704018
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.30819562
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28559573
33Non-small cell lung cancer_Homo sapiens_hsa052231.28551985
34Pertussis_Homo sapiens_hsa051331.17354330
35Platelet activation_Homo sapiens_hsa046111.11193729
36Allograft rejection_Homo sapiens_hsa053301.10872967
37Rheumatoid arthritis_Homo sapiens_hsa053231.03102708
38Notch signaling pathway_Homo sapiens_hsa043301.02220717
39Prolactin signaling pathway_Homo sapiens_hsa049171.02124336
40Pancreatic cancer_Homo sapiens_hsa052121.00710960
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00376584
42Hepatitis C_Homo sapiens_hsa051601.00142419
43Salmonella infection_Homo sapiens_hsa051320.98017713
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97505842
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.97445279
46Leukocyte transendothelial migration_Homo sapiens_hsa046700.97149506
47Herpes simplex infection_Homo sapiens_hsa051680.94785504
48Phagosome_Homo sapiens_hsa041450.94653013
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94385171
50Autoimmune thyroid disease_Homo sapiens_hsa053200.94260234
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.92780524
52Apoptosis_Homo sapiens_hsa042100.89608275
53Chronic myeloid leukemia_Homo sapiens_hsa052200.88998854
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88897859
55Amoebiasis_Homo sapiens_hsa051460.88511528
56African trypanosomiasis_Homo sapiens_hsa051430.86779781
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86547919
58FoxO signaling pathway_Homo sapiens_hsa040680.85443418
59Type I diabetes mellitus_Homo sapiens_hsa049400.83433441
60Endometrial cancer_Homo sapiens_hsa052130.82274737
61Asthma_Homo sapiens_hsa053100.80904212
62Type II diabetes mellitus_Homo sapiens_hsa049300.80506717
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79225148
64Antigen processing and presentation_Homo sapiens_hsa046120.75733358
65VEGF signaling pathway_Homo sapiens_hsa043700.73332572
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70740573
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69868773
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69740715
69MAPK signaling pathway_Homo sapiens_hsa040100.68394581
70Renin-angiotensin system_Homo sapiens_hsa046140.67684227
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67190513
72HIF-1 signaling pathway_Homo sapiens_hsa040660.64663915
73Regulation of autophagy_Homo sapiens_hsa041400.64579553
74Prostate cancer_Homo sapiens_hsa052150.63460593
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63083293
76Other glycan degradation_Homo sapiens_hsa005110.62145530
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.60855151
78Choline metabolism in cancer_Homo sapiens_hsa052310.59762882
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56706418
80Colorectal cancer_Homo sapiens_hsa052100.55903773
81Shigellosis_Homo sapiens_hsa051310.55174034
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.54736296
83GnRH signaling pathway_Homo sapiens_hsa049120.53924129
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51627212
85Epstein-Barr virus infection_Homo sapiens_hsa051690.50638638
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49532314
87Insulin resistance_Homo sapiens_hsa049310.48260320
88mTOR signaling pathway_Homo sapiens_hsa041500.47914495
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46895634
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46770092
91cAMP signaling pathway_Homo sapiens_hsa040240.46311661
92ErbB signaling pathway_Homo sapiens_hsa040120.46137001
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46104156
94Estrogen signaling pathway_Homo sapiens_hsa049150.42575397
95Ras signaling pathway_Homo sapiens_hsa040140.40191280
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.38854665
97Cholinergic synapse_Homo sapiens_hsa047250.37209641
98HTLV-I infection_Homo sapiens_hsa051660.36425600
99Arachidonic acid metabolism_Homo sapiens_hsa005900.35558237
100Serotonergic synapse_Homo sapiens_hsa047260.33897112

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