RBMS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.30077503
2protein heterotrimerization (GO:0070208)4.24022106
3pericardium development (GO:0060039)3.99810038
4cell adhesion mediated by integrin (GO:0033627)3.81779258
5glomerular basement membrane development (GO:0032836)3.71521916
6basement membrane organization (GO:0071711)3.65368428
7cardiac myofibril assembly (GO:0055003)3.57567132
8skin morphogenesis (GO:0043589)3.56628361
9mesodermal cell differentiation (GO:0048333)3.50738537
10substrate-dependent cell migration (GO:0006929)3.47536458
11smooth muscle tissue development (GO:0048745)3.41856197
12vascular endothelial growth factor signaling pathway (GO:0038084)3.41497318
13hippo signaling (GO:0035329)3.39907011
14chondrocyte proliferation (GO:0035988)3.33457221
15plasma membrane repair (GO:0001778)3.27208235
16regulation of hippo signaling (GO:0035330)3.26249856
17collagen fibril organization (GO:0030199)3.25823438
18artery development (GO:0060840)3.25195288
19bone trabecula formation (GO:0060346)3.24013992
20sarcomere organization (GO:0045214)3.21195775
21regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.19002570
22sequestering of extracellular ligand from receptor (GO:0035581)3.17426420
23epithelial cell-cell adhesion (GO:0090136)3.16676755
24regulation of SMAD protein import into nucleus (GO:0060390)3.16358596
25lung vasculature development (GO:0060426)3.15085018
26cellular response to vitamin (GO:0071295)3.12996606
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.09516116
28surfactant homeostasis (GO:0043129)3.08468244
29sprouting angiogenesis (GO:0002040)3.05053121
30polarized epithelial cell differentiation (GO:0030859)3.01172390
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.99746314
32retina vasculature morphogenesis in camera-type eye (GO:0061299)2.94166657
33myofibril assembly (GO:0030239)2.93331962
34positive regulation of SMAD protein import into nucleus (GO:0060391)2.93070975
35regulation of transforming growth factor beta2 production (GO:0032909)2.91456146
36notochord development (GO:0030903)2.90500818
37endodermal cell differentiation (GO:0035987)2.89869365
38muscle filament sliding (GO:0030049)2.89164859
39actin-myosin filament sliding (GO:0033275)2.89164859
40establishment of apical/basal cell polarity (GO:0035089)2.88949736
41axon extension involved in axon guidance (GO:0048846)2.87699783
42neuron projection extension involved in neuron projection guidance (GO:1902284)2.87699783
43negative regulation of axon extension involved in axon guidance (GO:0048843)2.86748498
44regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.86419789
45regulation of tight junction assembly (GO:2000810)2.85508502
46renal filtration (GO:0097205)2.85077116
47endocardial cushion development (GO:0003197)2.85063997
48negative regulation of chondrocyte differentiation (GO:0032331)2.83546634
49regulation of cardioblast differentiation (GO:0051890)2.82666298
50negative regulation of protein localization to cell surface (GO:2000009)2.80608691
51cell-substrate junction assembly (GO:0007044)2.79140216
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.78444683
53cellular response to vitamin D (GO:0071305)2.78432934
54glomerular filtration (GO:0003094)2.77881012
55wound healing, spreading of cells (GO:0044319)2.75817852
56cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.75216843
57cardiac muscle cell development (GO:0055013)2.74468545
58regulation of axon extension involved in axon guidance (GO:0048841)2.71804360
59type B pancreatic cell proliferation (GO:0044342)2.70746075
60cardiac cell development (GO:0055006)2.68868761
61cell migration involved in sprouting angiogenesis (GO:0002042)2.68644225
62embryonic foregut morphogenesis (GO:0048617)2.68314166
63low-density lipoprotein particle clearance (GO:0034383)2.67648278
64hemidesmosome assembly (GO:0031581)2.67352626
65lymph vessel development (GO:0001945)2.66418713
66fibroblast migration (GO:0010761)2.65736344
67muscle cell migration (GO:0014812)2.65605897
68lung lobe morphogenesis (GO:0060463)2.65156527
69negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.65099368
70regulation of posttranscriptional gene silencing (GO:0060147)2.64914604
71regulation of gene silencing by miRNA (GO:0060964)2.64914604
72regulation of gene silencing by RNA (GO:0060966)2.64914604
73positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.63833748
74wound healing, spreading of epidermal cells (GO:0035313)2.63688192
75chemical homeostasis within a tissue (GO:0048875)2.63668108
76atrioventricular valve morphogenesis (GO:0003181)2.63416658
77negative regulation of cartilage development (GO:0061037)2.63034095
78apoptotic cell clearance (GO:0043277)2.62622044
79adhesion of symbiont to host cell (GO:0044650)2.61788550
80virion attachment to host cell (GO:0019062)2.61788550
81actin-mediated cell contraction (GO:0070252)2.61147610
82regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.59774268
83branching involved in salivary gland morphogenesis (GO:0060445)2.59516746
84glomerular visceral epithelial cell development (GO:0072015)2.58400618
85cell proliferation involved in metanephros development (GO:0072203)2.57850739
86venous blood vessel morphogenesis (GO:0048845)2.56348412
87cell migration involved in heart development (GO:0060973)2.56020589
88adherens junction assembly (GO:0034333)2.55458267
89endothelial cell morphogenesis (GO:0001886)2.54281969
90embryonic camera-type eye development (GO:0031076)2.54217591
91bundle of His cell to Purkinje myocyte communication (GO:0086069)2.53494916
92extracellular matrix assembly (GO:0085029)2.52626495
93cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.52140938
94metanephric mesenchyme development (GO:0072075)2.51837954
95G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.51762755
96substrate adhesion-dependent cell spreading (GO:0034446)2.51271860
97endothelium development (GO:0003158)2.50141855
98lymphangiogenesis (GO:0001946)2.49991125
99mesenchyme development (GO:0060485)2.49934331
100mesenchymal-epithelial cell signaling (GO:0060638)2.48937986
101anatomical structure regression (GO:0060033)2.48170149
102positive regulation of cartilage development (GO:0061036)2.47971061
103hypotonic response (GO:0006971)2.47860531
104trabecula formation (GO:0060343)2.47190293
105negative regulation of keratinocyte proliferation (GO:0010839)2.47101441
106regulation of G0 to G1 transition (GO:0070316)2.46858490
107regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.46148022
108desmosome organization (GO:0002934)2.45391336
109kidney mesenchyme development (GO:0072074)2.45046436
110vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.45007236
111apoptotic process involved in morphogenesis (GO:0060561)2.44594900
112actomyosin structure organization (GO:0031032)2.44449072
113outer ear morphogenesis (GO:0042473)2.43820734
114response to gravity (GO:0009629)2.42950905
115organ formation (GO:0048645)2.42536230
116regulation of axon guidance (GO:1902667)2.42191557
117regulation of mitotic spindle organization (GO:0060236)2.41208974
118positive regulation of blood vessel endothelial cell migration (GO:0043536)2.40465161
119positive regulation of epithelial to mesenchymal transition (GO:0010718)2.40130075
120muscle cell fate commitment (GO:0042693)2.38748372
121negative regulation of axon guidance (GO:1902668)2.38266141
122neuron remodeling (GO:0016322)2.37517238
123neural crest cell development (GO:0014032)2.37388596
124regulation of heart morphogenesis (GO:2000826)2.36842694
125outflow tract septum morphogenesis (GO:0003148)2.36717947
126regulation of integrin-mediated signaling pathway (GO:2001044)2.35404672
127ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.35153342
128protein hydroxylation (GO:0018126)2.34814087
129regulation of endothelial cell differentiation (GO:0045601)2.34660798
130endocrine hormone secretion (GO:0060986)2.34215959
131regulation of glomerular filtration (GO:0003093)2.33330587
132regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.33263598
133positive regulation of osteoblast proliferation (GO:0033690)2.31976309
134negative regulation of Rho protein signal transduction (GO:0035024)2.31329114
135cardiac muscle tissue morphogenesis (GO:0055008)2.31190569
136positive regulation of endothelial cell migration (GO:0010595)2.30999101
137peptidyl-proline hydroxylation (GO:0019511)2.30889568
138protein localization to cell surface (GO:0034394)2.30758333
139collagen metabolic process (GO:0032963)2.30509962
140negative regulation of fatty acid transport (GO:2000192)2.30509188
141maternal placenta development (GO:0001893)2.30166518
142membrane raft organization (GO:0031579)2.30146174
143regulation of integrin activation (GO:0033623)2.30031916
144face morphogenesis (GO:0060325)2.29770790
145cell-substrate adherens junction assembly (GO:0007045)2.29707580
146focal adhesion assembly (GO:0048041)2.29707580
147heart trabecula formation (GO:0060347)2.28625285
148endothelial cell chemotaxis (GO:0035767)2.27900551
149blood vessel endothelial cell migration (GO:0043534)2.27772349
150wound healing (GO:0042060)2.27746277
151dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.27736584
152morphogenesis of an endothelium (GO:0003159)2.26912312
153endothelial tube morphogenesis (GO:0061154)2.26912312
154heterochromatin organization (GO:0070828)2.26683174
155positive regulation of endothelial cell apoptotic process (GO:2000353)2.26348155
156regulation of cartilage development (GO:0061035)2.26336744
157negative regulation of catenin import into nucleus (GO:0035414)2.25258157
158blood vessel maturation (GO:0001955)2.23047762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.76836711
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.74237358
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.41536055
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.40104681
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75413951
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.72058136
7CLOCK_20551151_ChIP-Seq_293T_Human2.68315369
8E2F7_22180533_ChIP-Seq_HELA_Human2.62287066
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.54603032
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.54603032
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.54603032
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.52407843
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.49366063
14GATA2_21666600_ChIP-Seq_HMVEC_Human2.34729809
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.33396154
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.32984698
17ZNF217_24962896_ChIP-Seq_MCF-7_Human2.28210343
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22789369
19RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.18262828
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.09070210
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06527172
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.03711154
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.01264355
24TP53_16413492_ChIP-PET_HCT116_Human2.00279829
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98827555
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88673353
27* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.87328037
28AHR_22903824_ChIP-Seq_MCF-7_Human1.86037192
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.83621830
30SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.83336706
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.81016721
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79930923
33JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76781189
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.73352853
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72749893
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.70716724
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.69094229
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67151724
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.67082557
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.67082557
41TP53_18474530_ChIP-ChIP_U2OS_Human1.66588733
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66252604
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65520915
44* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62816364
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.61857517
46JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58593207
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.58011432
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.58002020
49TBX20_22328084_ChIP-Seq_HEART_Mouse1.57713099
50TBX20_22080862_ChIP-Seq_HEART_Mouse1.57713099
51AR_21909140_ChIP-Seq_LNCAP_Human1.57582380
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55989081
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54047554
54NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.53449284
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51495192
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.50101259
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.49914330
58RACK7_27058665_Chip-Seq_MCF-7_Human1.48868499
59GBX2_23144817_ChIP-Seq_PC3_Human1.47789303
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46446994
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45164980
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44701356
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44085632
64ATF3_27146783_Chip-Seq_COLON_Human1.43976842
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.42771793
66ZNF263_19887448_ChIP-Seq_K562_Human1.42724888
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42329113
68TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41461930
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41413599
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40923297
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.39018421
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36927990
73BRD4_25478319_ChIP-Seq_HGPS_Human1.35703416
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35385542
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.33922291
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.33158153
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32810958
78* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32741981
79ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32317542
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32248505
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.30506145
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29224841
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29224841
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.29163009
85* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29020964
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28552991
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27491770
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27044908
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26186005
90* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25668796
91MYC_22102868_ChIP-Seq_BL_Human1.24852185
92SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23826304
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.23653885
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23217832
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22205442
96TP53_23651856_ChIP-Seq_MEFs_Mouse1.20765369
97SOX2_20726797_ChIP-Seq_SW620_Human1.20373440
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20224616
99KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20161776
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20120089
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19956376
102TP63_23658742_ChIP-Seq_EP156T_Human1.19759172
103EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19418897
104RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19418897
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19390745
106EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18642242
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18087100
108MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17978035
109TP53_22127205_ChIP-Seq_IMR90_Human1.16677731
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16515634
111FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16243800
112SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15870186
113RXR_22108803_ChIP-Seq_LS180_Human1.15005312
114SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14677410
115SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13987276
116* FOXO3_23340844_ChIP-Seq_DLD1_Human1.13748270
117CJUN_26792858_Chip-Seq_BT549_Human1.13641812
118SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13232788
119* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.12038189
120NANOG_21062744_ChIP-ChIP_HESCs_Human1.10979011
121* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10548586
122SMAD4_21799915_ChIP-Seq_A2780_Human1.10349940
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08341117
124MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07892556
125STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07874330
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07644996
127CDX2_20551321_ChIP-Seq_CACO-2_Human1.07234668
128KDM2B_26808549_Chip-Seq_DND41_Human1.06693709
129NCOR1_26117541_ChIP-Seq_K562_Human1.06181362
130* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05831547
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04389489
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04278683
133ESR1_20079471_ChIP-ChIP_T-47D_Human1.03432825
134ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03119122
135GATA4_25053715_ChIP-Seq_YYC3_Human1.02748945
136NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02716483
137HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02597460
138ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02148072
139ISL1_27105846_Chip-Seq_CPCs_Mouse1.01956221
140VDR_21846776_ChIP-Seq_THP-1_Human1.01726174
141JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01665297
142SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01527345
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01338710
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00681928
145STAT3_23295773_ChIP-Seq_U87_Human1.00387979
146SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99851651
147BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99778068
148P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98751095
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98668646
150DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98663260
151CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98075220
152* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97683978
153KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97066477
154* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97056045
155TP53_20018659_ChIP-ChIP_R1E_Mouse0.97010755
156FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96651066
157TCF4_18268006_ChIP-ChIP_LS174T_Human0.95556998
158RNF2_27304074_Chip-Seq_ESCs_Mouse0.95151853
159STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92172304
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91675048
161SMAD4_21741376_ChIP-Seq_HESCs_Human0.90062387
162PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90048625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.61351091
2MP0005275_abnormal_skin_tensile3.09148747
3MP0003705_abnormal_hypodermis_morpholog3.02181790
4MP0005503_abnormal_tendon_morphology2.87310435
5MP0004272_abnormal_basement_membrane2.64720275
6MP0000013_abnormal_adipose_tissue2.36237963
7MP0004084_abnormal_cardiac_muscle2.35452269
8MP0010030_abnormal_orbit_morphology2.32650357
9MP0003279_aneurysm2.30831566
10MP0003566_abnormal_cell_adhesion2.15200104
11MP0005623_abnormal_meninges_morphology2.10083325
12MP0009780_abnormal_chondrocyte_physiolo2.07611254
13MP0010368_abnormal_lymphatic_system2.00781924
14MP0001542_abnormal_bone_strength1.91765913
15MP0005595_abnormal_vascular_smooth1.78024985
16MP0003828_pulmonary_edema1.71200635
17MP0010352_gastrointestinal_tract_polyps1.69440405
18MP0000750_abnormal_muscle_regeneration1.68032549
19MP0003941_abnormal_skin_development1.64435110
20MP0005670_abnormal_white_adipose1.59453550
21MP0001958_emphysema1.57494466
22MP0003567_abnormal_fetal_cardiomyocyte1.53958361
23MP0005508_abnormal_skeleton_morphology1.53633619
24MP0010630_abnormal_cardiac_muscle1.52529950
25MP0008775_abnormal_heart_ventricle1.50409780
26MP0009384_cardiac_valve_regurgitation1.49774132
27MP0005023_abnormal_wound_healing1.48342009
28MP0000733_abnormal_muscle_development1.47466611
29MP0000751_myopathy1.47252136
30MP0001879_abnormal_lymphatic_vessel1.46613803
31MP0003385_abnormal_body_wall1.46304887
32MP0005330_cardiomyopathy1.45615083
33MP0006138_congestive_heart_failure1.44789613
34MP0005076_abnormal_cell_differentiation1.43892977
35MP0002837_dystrophic_cardiac_calcinosis1.43713818
36MP0004185_abnormal_adipocyte_glucose1.43223220
37MP0009053_abnormal_anal_canal1.40702114
38MP0004087_abnormal_muscle_fiber1.39981389
39MP0000767_abnormal_smooth_muscle1.39907273
40MP0005409_darkened_coat_color1.37256328
41MP0002060_abnormal_skin_morphology1.36451763
42MP0000749_muscle_degeneration1.34231162
43MP0004782_abnormal_surfactant_physiolog1.33140053
44MP0005666_abnormal_adipose_tissue1.32140620
45MP0001299_abnormal_eye_distance/1.31000806
46MP0009278_abnormal_bone_marrow1.25794679
47MP0002249_abnormal_larynx_morphology1.25491966
48MP0004036_abnormal_muscle_relaxation1.25105321
49MP0009250_abnormal_appendicular_skeleto1.24945973
50MP0002896_abnormal_bone_mineralization1.23493774
51MP0005385_cardiovascular_system_phenoty1.23458205
52MP0001544_abnormal_cardiovascular_syste1.23458205
53MP0002108_abnormal_muscle_morphology1.22921050
54MP0003950_abnormal_plasma_membrane1.21595146
55MP0003942_abnormal_urinary_system1.21198929
56MP0004233_abnormal_muscle_weight1.21021469
57MP0002877_abnormal_melanocyte_morpholog1.20920327
58MP0003091_abnormal_cell_migration1.18059261
59MP0005375_adipose_tissue_phenotype1.13641903
60MP0003984_embryonic_growth_retardation1.09626615
61MP0002088_abnormal_embryonic_growth/wei1.09059649
62MP0002972_abnormal_cardiac_muscle1.08512369
63MP0010386_abnormal_urinary_bladder1.07691979
64MP0004197_abnormal_fetal_growth/weight/1.07062671
65MP0000428_abnormal_craniofacial_morphol1.06203792
66MP0002925_abnormal_cardiovascular_devel1.06038987
67MP0000003_abnormal_adipose_tissue1.05247191
68MP0005380_embryogenesis_phenotype1.04248095
69MP0001672_abnormal_embryogenesis/_devel1.04248095
70MP0002932_abnormal_joint_morphology1.03442931
71MP0005164_abnormal_response_to1.02994078
72MP0004130_abnormal_muscle_cell1.01852666
73MP0000266_abnormal_heart_morphology1.01848087
74MP0003115_abnormal_respiratory_system1.01735417
75MP0002128_abnormal_blood_circulation1.01495912
76MP0003935_abnormal_craniofacial_develop1.01042538
77MP0000759_abnormal_skeletal_muscle1.00998007
78MP0006054_spinal_hemorrhage1.00928683
79MP0000534_abnormal_ureter_morphology0.99416826
80MP0000537_abnormal_urethra_morphology0.98526455
81MP0005257_abnormal_intraocular_pressure0.97388097
82MP0004215_abnormal_myocardial_fiber0.97099173
83MP0002086_abnormal_extraembryonic_tissu0.96917936
84MP0003045_fibrosis0.95987456
85MP0002269_muscular_atrophy0.95873719
86MP0000516_abnormal_urinary_system0.95788719
87MP0005367_renal/urinary_system_phenotyp0.95788719
88MP0005197_abnormal_uvea_morphology0.95617344
89MP0001614_abnormal_blood_vessel0.95232664
90MP0005165_increased_susceptibility_to0.94346879
91MP0005620_abnormal_muscle_contractility0.94246744
92MP0005369_muscle_phenotype0.93780129
93MP0002106_abnormal_muscle_physiology0.93030556
94MP0000762_abnormal_tongue_morphology0.92992805
95MP0000049_abnormal_middle_ear0.92377724
96MP0002282_abnormal_trachea_morphology0.91737641
97MP0000432_abnormal_head_morphology0.89425091
98MP0002295_abnormal_pulmonary_circulatio0.89248894
99MP0002168_other_aberrant_phenotype0.89216404
100MP0002127_abnormal_cardiovascular_syste0.88941948
101MP0000538_abnormal_urinary_bladder0.88562935
102MP0002085_abnormal_embryonic_tissue0.87911998
103MP0000343_altered_response_to0.87766096
104MP0003755_abnormal_palate_morphology0.87763580
105MP0002234_abnormal_pharynx_morphology0.87606899
106MP0003937_abnormal_limbs/digits/tail_de0.86739237
107MP0002933_joint_inflammation0.85365914
108MP0002111_abnormal_tail_morphology0.84828112
109MP0005171_absent_coat_pigmentation0.84619162
110MP0005388_respiratory_system_phenotype0.83778442
111MP0002133_abnormal_respiratory_system0.83778442
112MP0002084_abnormal_developmental_patter0.82435086
113MP0000383_abnormal_hair_follicle0.81763575
114MP0004484_altered_response_of0.80996990
115MP0001293_anophthalmia0.79530520
116MP0001697_abnormal_embryo_size0.79479526
117MP0005083_abnormal_biliary_tract0.78858150
118MP0002115_abnormal_skeleton_extremities0.78263247
119MP0000163_abnormal_cartilage_morphology0.78088326
120MP0010678_abnormal_skin_adnexa0.77936141
121MP0003123_paternal_imprinting0.76602271
122MP0001915_intracranial_hemorrhage0.76460952
123MP0002138_abnormal_hepatobiliary_system0.75714515
124MP0001243_abnormal_dermal_layer0.75340339
125MP0003119_abnormal_digestive_system0.75246914
126MP0000569_abnormal_digit_pigmentation0.75059138
127MP0001175_abnormal_lung_morphology0.74599682
128MP0004957_abnormal_blastocyst_morpholog0.74343814
129MP0000249_abnormal_blood_vessel0.74044772
130MP0000427_abnormal_hair_cycle0.73573074
131MP0000230_abnormal_systemic_arterial0.73376744
132MP0005390_skeleton_phenotype0.73251476
133MP0000467_abnormal_esophagus_morphology0.71639660
134MP0003283_abnormal_digestive_organ0.70390518
135MP0000613_abnormal_salivary_gland0.67716331
136MP0002332_abnormal_exercise_endurance0.66991463
137MP0001661_extended_life_span0.65287328
138MP0002109_abnormal_limb_morphology0.64912673

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.62485824
2Premature rupture of membranes (HP:0001788)4.93044070
3Vascular tortuosity (HP:0004948)4.26664559
4Ankle contracture (HP:0006466)4.21866588
5Arterial tortuosity (HP:0005116)4.07645507
6Increased connective tissue (HP:0009025)3.91546340
7Shallow orbits (HP:0000586)3.73975127
8Broad metatarsal (HP:0001783)3.70747934
9Right ventricular cardiomyopathy (HP:0011663)3.38229463
10Cerebral aneurysm (HP:0004944)3.34262877
11Ventricular tachycardia (HP:0004756)3.32176433
12Aortic dissection (HP:0002647)3.27371709
13Type 1 muscle fiber predominance (HP:0003803)3.26340883
14Muscle fiber splitting (HP:0003555)3.01735747
15Aortic aneurysm (HP:0004942)3.01001426
16Spinal rigidity (HP:0003306)2.84612888
17Soft skin (HP:0000977)2.77419577
18Atrophic scars (HP:0001075)2.69060687
19Overgrowth (HP:0001548)2.66382466
20Lipoatrophy (HP:0100578)2.62945602
21Hyporeflexia of lower limbs (HP:0002600)2.58891273
22Short 4th metacarpal (HP:0010044)2.58855401
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58855401
24Rectal prolapse (HP:0002035)2.58735988
25Sudden death (HP:0001699)2.58627962
26Spondylolisthesis (HP:0003302)2.55651124
27Aortic valve stenosis (HP:0001650)2.54003119
28Short nail (HP:0001799)2.51801692
29Exercise-induced muscle cramps (HP:0003710)2.50220955
30Cervical subluxation (HP:0003308)2.47789916
31Abnormality of the 4th metacarpal (HP:0010012)2.45971748
32Cardiovascular calcification (HP:0011915)2.44759266
33Blue sclerae (HP:0000592)2.44424103
34Aortic regurgitation (HP:0001659)2.36969953
35Selective tooth agenesis (HP:0001592)2.33293331
36Dilatation of the ascending aorta (HP:0005111)2.32984564
37Aneurysm (HP:0002617)2.32788873
38Mildly elevated creatine phosphokinase (HP:0008180)2.31220597
39Bladder diverticulum (HP:0000015)2.29431803
40Wrist flexion contracture (HP:0001239)2.29346418
41Fragile skin (HP:0001030)2.24551878
42Increased variability in muscle fiber diameter (HP:0003557)2.22898122
43Mesangial abnormality (HP:0001966)2.21692962
44Difficulty climbing stairs (HP:0003551)2.18905318
45Broad toe (HP:0001837)2.16087334
46Broad face (HP:0000283)2.13414365
47Mitral valve prolapse (HP:0001634)2.12707062
48Follicular hyperkeratosis (HP:0007502)2.11876394
49Wide anterior fontanel (HP:0000260)2.11749145
50Tibial bowing (HP:0002982)2.09112503
51Mesomelia (HP:0003027)2.08404917
52Limited hip movement (HP:0008800)2.07005652
53Ulnar bowing (HP:0003031)2.06830180
54Peritonitis (HP:0002586)2.06577737
55Difficulty running (HP:0009046)2.06243869
56Lymphangioma (HP:0100764)2.05530932
57Abnormality of the calf musculature (HP:0001430)2.05307200
58Increased corneal curvature (HP:0100692)2.04857074
59Keratoconus (HP:0000563)2.04857074
60Wormian bones (HP:0002645)2.03941343
61Atrial fibrillation (HP:0005110)2.02748898
62Abnormality of skeletal muscle fiber size (HP:0012084)2.02732584
63Spinal cord lesions (HP:0100561)2.02390486
64Syringomyelia (HP:0003396)2.02390486
65Vertebral compression fractures (HP:0002953)1.99147709
66Hip contracture (HP:0003273)1.97048238
67Genu recurvatum (HP:0002816)1.96710306
68Interstitial pulmonary disease (HP:0006530)1.96204040
69Neonatal short-limb short stature (HP:0008921)1.95581761
70Vascular calcification (HP:0004934)1.95160276
71Abnormality of dentin (HP:0010299)1.95052668
72Broad hallux (HP:0010055)1.94572821
73Tubular atrophy (HP:0000092)1.93420821
74Abnormality of the left ventricular outflow tract (HP:0011103)1.93264127
75Subaortic stenosis (HP:0001682)1.93264127
76Joint stiffness (HP:0001387)1.92462156
77Distal lower limb muscle weakness (HP:0009053)1.91534953
78Bradycardia (HP:0001662)1.88890967
79Glucose intolerance (HP:0000833)1.88852943
80Coronal craniosynostosis (HP:0004440)1.87368416
81Scapular winging (HP:0003691)1.87259977
82Primary atrial arrhythmia (HP:0001692)1.86910038
83Elbow flexion contracture (HP:0002987)1.86487906
84Supraventricular arrhythmia (HP:0005115)1.86153798
85Osteolytic defects of the hand bones (HP:0009699)1.85988478
86Osteolytic defects of the phalanges of the hand (HP:0009771)1.85988478
87Reduced subcutaneous adipose tissue (HP:0003758)1.84404069
88Camptodactyly of toe (HP:0001836)1.83782547
89Radial bowing (HP:0002986)1.83703922
90Natal tooth (HP:0000695)1.82179928
91Abnormality of the nasal septum (HP:0000419)1.79676036
92Generalized amyotrophy (HP:0003700)1.78954620
93Morphological abnormality of the middle ear (HP:0008609)1.78806639
94Ovoid vertebral bodies (HP:0003300)1.78497804
95Mitral stenosis (HP:0001718)1.78314338
96Supraventricular tachycardia (HP:0004755)1.77901310
97Pulmonary artery stenosis (HP:0004415)1.77884320
98Bowed forearm bones (HP:0003956)1.77864349
99Bowing of the arm (HP:0006488)1.77864349
100Broad ribs (HP:0000885)1.76929597
101Hypoplastic ischia (HP:0003175)1.76906696
102Long toe (HP:0010511)1.76851898
103Striae distensae (HP:0001065)1.76316844
104Multiple enchondromatosis (HP:0005701)1.75798186
105Dilated cardiomyopathy (HP:0001644)1.75036756
106Calf muscle hypertrophy (HP:0008981)1.73945062
107Myoglobinuria (HP:0002913)1.73113841
108Abnormal hemoglobin (HP:0011902)1.72457068
109Abnormality of the calcaneus (HP:0008364)1.72234643
110Round ear (HP:0100830)1.71563568
111Tubulointerstitial fibrosis (HP:0005576)1.70704815
112Abnormality of the anterior chamber (HP:0000593)1.70311402
113Hyperextensible skin (HP:0000974)1.70237096
114Ectopia lentis (HP:0001083)1.69468706
115Preaxial foot polydactyly (HP:0001841)1.68785529
116Knee flexion contracture (HP:0006380)1.68697195
117Abnormality of the right ventricle (HP:0001707)1.68677198
118Renal duplication (HP:0000075)1.68100907
119Hypoplasia of the iris (HP:0007676)1.67967322
120Slender build (HP:0001533)1.67839192
121Abnormality of the acetabulum (HP:0003170)1.67806514
122Hematochezia (HP:0002573)1.67655679
123Biconcave vertebral bodies (HP:0004586)1.67314857
124Mitral regurgitation (HP:0001653)1.66924776
125Joint laxity (HP:0001388)1.66505232
126Protruding ear (HP:0000411)1.66406348
127Fused cervical vertebrae (HP:0002949)1.66006018
128Milia (HP:0001056)1.65884007
129Acanthosis nigricans (HP:0000956)1.62890651
130Adactyly (HP:0009776)1.62839868
131Short hallux (HP:0010109)1.62600634
132Asymmetric septal hypertrophy (HP:0001670)1.62592858
133Bulbous nose (HP:0000414)1.61361353
134Hydroureter (HP:0000072)1.60623278
135Abnormality of the distal phalanx of the thumb (HP:0009617)1.60227856
136EMG: myopathic abnormalities (HP:0003458)1.59960075
137Tarsal synostosis (HP:0008368)1.59864020
138Anterior segment dysgenesis (HP:0007700)1.59862802
139Coxa vara (HP:0002812)1.59686323
140Abnormality of the distal phalanges of the toes (HP:0010182)1.59380791
141Deviation of the hallux (HP:0010051)1.58737568
142Bowel diverticulosis (HP:0005222)1.58317151
143Broad thumb (HP:0011304)1.57955872
144Aplasia/Hypoplasia of the hallux (HP:0008362)1.56784471
145Short humerus (HP:0005792)1.56576081
146Entropion (HP:0000621)1.56018377
147Short 5th finger (HP:0009237)1.54295450
148Disproportionate tall stature (HP:0001519)1.53868922
149Chorioretinal atrophy (HP:0000533)1.53313915
150Infantile muscular hypotonia (HP:0008947)1.52690397
151Buphthalmos (HP:0000557)1.50133266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.71210022
2TRIB33.70742636
3FRK2.80177744
4LATS12.73228647
5DDR22.73047860
6PDGFRA2.53828821
7CDK122.43010669
8PKN22.34872428
9ERN12.26384431
10EPHB22.03802961
11SIK11.91976139
12MYLK1.85588043
13LATS21.80035445
14TGFBR21.75943384
15MAP3K101.72979116
16TIE11.71807007
17DMPK1.62485986
18STK38L1.62466704
19NTRK11.52304771
20STK381.52088487
21EPHA21.50493703
22STK31.49808066
23RIPK11.46360265
24BMX1.43409429
25ADRBK11.43185188
26ERBB41.39948021
27EPHB11.34611648
28PAK21.32583186
29ICK1.32348034
30LRRK21.30658662
31CDK71.29126671
32BMPR1B1.28011343
33MET1.27479796
34STK101.24687201
35OBSCN1.24296037
36WNK41.23832776
37LIMK11.21574537
38EEF2K1.21322537
39PIK3CA1.20689711
40TRPM71.20463815
41CAMK1D1.14457634
42MTOR1.14366892
43KDR1.10137355
44FLT31.08834864
45PAK41.07964477
46ILK1.04522519
47RPS6KA41.03983916
48FER1.03035025
49PTK61.02924743
50NEK11.00799733
51PTK21.00336872
52MAPK150.99664566
53RPS6KA20.99615186
54RPS6KB20.97746239
55MAP3K70.96181275
56ADRBK20.95964741
57GRK70.95770678
58BCKDK0.95661113
59MAP2K30.94512421
60MAPKAPK30.93149550
61TTK0.92420243
62GRK10.92248441
63TGFBR10.91712765
64STK390.91595694
65ZAK0.91332066
66NME20.90871984
67PDK30.90774989
68PDK40.90774989
69LMTK20.89940929
70CDK60.89846088
71NEK90.88728810
72MELK0.88029068
73PRKD20.83587880
74PIK3CG0.83435378
75STK240.83377179
76CDK40.82527820
77FGFR10.81007988
78INSRR0.80445708
79STK40.80101037
80MOS0.78709502
81EPHA30.77775221
82MAP3K30.77653515
83PRKCE0.76726377
84NEK20.76592924
85CHUK0.73804968
86MAP3K80.72730607
87PDGFRB0.70530778
88CDC42BPA0.69195970
89ABL20.67826098
90PRKD10.63508681
91MAP2K10.61458506
92PIM20.61191053
93MAPK70.59561618
94ROCK10.59350423
95PDK20.57197067
96MAP3K60.57016852
97PIM10.56839130
98CDK80.55604247
99AURKB0.53124206
100PRKAA20.52041540
101RPS6KL10.51439199
102RPS6KC10.51439199
103NUAK10.51313692
104MST1R0.51281540
105SGK30.51040603
106ACVR1B0.50032582
107AKT30.49859177
108FGFR30.49297066
109PNCK0.49131895
110PLK10.48723193
111AKT20.48346210
112PAK30.48342336
113ROCK20.47547634
114TAOK20.47337085
115MAPKAPK20.47179660
116TYRO30.47046503
117RPS6KA60.45822553
118CSK0.45133153
119PHKG10.45105503
120PHKG20.45105503
121BRD40.44462655
122WEE10.43107490
123DYRK1B0.41919206
124PAK10.41555398
125BRSK20.41467094
126WNK10.39256869
127PRKG20.38803500
128MUSK0.38357658
129FGFR20.37833322
130GSK3A0.37774088
131PTK2B0.37426011
132CAMK1G0.37361839
133ZAP700.36344272
134MARK20.33106225
135PRKAA10.32186306
136IGF1R0.30741153
137MAPKAPK50.28534189
138ABL10.28525335
139INSR0.27869806
140CAMK10.26877925

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.81773754
2Adherens junction_Homo sapiens_hsa045202.38834581
3Focal adhesion_Homo sapiens_hsa045102.33313201
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.30204770
5Small cell lung cancer_Homo sapiens_hsa052222.16709674
6Basal cell carcinoma_Homo sapiens_hsa052172.11869259
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.08717059
8Dilated cardiomyopathy_Homo sapiens_hsa054142.07435135
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00933189
10Hippo signaling pathway_Homo sapiens_hsa043901.97732332
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90865856
12Proteoglycans in cancer_Homo sapiens_hsa052051.89691102
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.84371111
14TGF-beta signaling pathway_Homo sapiens_hsa043501.84029768
15Viral myocarditis_Homo sapiens_hsa054161.81236803
16p53 signaling pathway_Homo sapiens_hsa041151.69769106
17MicroRNAs in cancer_Homo sapiens_hsa052061.66779699
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.64978831
19Dorso-ventral axis formation_Homo sapiens_hsa043201.58058082
20Hedgehog signaling pathway_Homo sapiens_hsa043401.57245738
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55561873
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.53280597
23Notch signaling pathway_Homo sapiens_hsa043301.51701678
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.49851871
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.45612208
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43301875
27Bladder cancer_Homo sapiens_hsa052191.38518709
28Axon guidance_Homo sapiens_hsa043601.35201524
29Amoebiasis_Homo sapiens_hsa051461.33310772
30Chronic myeloid leukemia_Homo sapiens_hsa052201.32045084
31Tight junction_Homo sapiens_hsa045301.31214891
32Cell cycle_Homo sapiens_hsa041101.28616428
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.25346821
34Lysine degradation_Homo sapiens_hsa003101.21815795
35Base excision repair_Homo sapiens_hsa034101.20225732
36Protein digestion and absorption_Homo sapiens_hsa049741.18343990
37Pathways in cancer_Homo sapiens_hsa052001.17834067
38Circadian rhythm_Homo sapiens_hsa047101.17784904
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.17123929
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15440431
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12418569
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12380600
43HTLV-I infection_Homo sapiens_hsa051661.09578125
44Fatty acid biosynthesis_Homo sapiens_hsa000611.08650027
45AMPK signaling pathway_Homo sapiens_hsa041521.08293521
46Selenocompound metabolism_Homo sapiens_hsa004501.04917614
47Propanoate metabolism_Homo sapiens_hsa006401.03931905
48Fatty acid degradation_Homo sapiens_hsa000711.03625264
49RNA transport_Homo sapiens_hsa030131.03440507
50Ovarian steroidogenesis_Homo sapiens_hsa049131.03074784
51Prostate cancer_Homo sapiens_hsa052151.02755351
52Fatty acid metabolism_Homo sapiens_hsa012121.02333394
53Mismatch repair_Homo sapiens_hsa034301.00603958
54Melanoma_Homo sapiens_hsa052180.99623180
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.99506362
56Sulfur metabolism_Homo sapiens_hsa009200.98800694
57Insulin resistance_Homo sapiens_hsa049310.98165336
58Linoleic acid metabolism_Homo sapiens_hsa005910.94752298
59Thyroid cancer_Homo sapiens_hsa052160.93522600
60Ribosome_Homo sapiens_hsa030100.93215768
61DNA replication_Homo sapiens_hsa030300.92302062
62mTOR signaling pathway_Homo sapiens_hsa041500.91869487
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90101747
64PPAR signaling pathway_Homo sapiens_hsa033200.89958864
65HIF-1 signaling pathway_Homo sapiens_hsa040660.89917518
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89042508
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89041136
68Toxoplasmosis_Homo sapiens_hsa051450.88678599
69Carbon metabolism_Homo sapiens_hsa012000.88129967
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87959412
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87066278
72Ras signaling pathway_Homo sapiens_hsa040140.86380046
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.86186402
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84286445
75Acute myeloid leukemia_Homo sapiens_hsa052210.84045734
76Complement and coagulation cascades_Homo sapiens_hsa046100.83630441
77Sphingolipid metabolism_Homo sapiens_hsa006000.83007729
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79979743
79Melanogenesis_Homo sapiens_hsa049160.79711032
80Phototransduction_Homo sapiens_hsa047440.79146820
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77460146
82Thyroid hormone synthesis_Homo sapiens_hsa049180.77287690
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.76758527
84Spliceosome_Homo sapiens_hsa030400.76453164
85Shigellosis_Homo sapiens_hsa051310.76347474
86Ether lipid metabolism_Homo sapiens_hsa005650.75965321
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75458553
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74155186
89Wnt signaling pathway_Homo sapiens_hsa043100.72890837
90Malaria_Homo sapiens_hsa051440.71765417
91Renin secretion_Homo sapiens_hsa049240.71668852
92ABC transporters_Homo sapiens_hsa020100.71034291
93MAPK signaling pathway_Homo sapiens_hsa040100.70193981
94Endometrial cancer_Homo sapiens_hsa052130.69061339
95cAMP signaling pathway_Homo sapiens_hsa040240.68438700
96Nitrogen metabolism_Homo sapiens_hsa009100.68160123
97Insulin signaling pathway_Homo sapiens_hsa049100.67471451
98Nucleotide excision repair_Homo sapiens_hsa034200.66982737
99Apoptosis_Homo sapiens_hsa042100.66711713
100mRNA surveillance pathway_Homo sapiens_hsa030150.66558927
101Viral carcinogenesis_Homo sapiens_hsa052030.66488807
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66328050
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64962892
104Histidine metabolism_Homo sapiens_hsa003400.64463505
105Pancreatic cancer_Homo sapiens_hsa052120.63422240
106One carbon pool by folate_Homo sapiens_hsa006700.63300603
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63258548
108Homologous recombination_Homo sapiens_hsa034400.62143148
109Salivary secretion_Homo sapiens_hsa049700.61718812
110Oxytocin signaling pathway_Homo sapiens_hsa049210.60027390
111Rap1 signaling pathway_Homo sapiens_hsa040150.59783126
112Endocytosis_Homo sapiens_hsa041440.58314655
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57162707
114Herpes simplex infection_Homo sapiens_hsa051680.55988875
115FoxO signaling pathway_Homo sapiens_hsa040680.55820804
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55525570
117Tryptophan metabolism_Homo sapiens_hsa003800.55450900
118Platelet activation_Homo sapiens_hsa046110.55299296
119Calcium signaling pathway_Homo sapiens_hsa040200.54771477
120Gap junction_Homo sapiens_hsa045400.54688425
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54579953
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53825513
123Legionellosis_Homo sapiens_hsa051340.53560373
124Colorectal cancer_Homo sapiens_hsa052100.52768084
125Biosynthesis of amino acids_Homo sapiens_hsa012300.52067530
126Fanconi anemia pathway_Homo sapiens_hsa034600.51647865
127Glycerolipid metabolism_Homo sapiens_hsa005610.51629285
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51478243
129Hepatitis B_Homo sapiens_hsa051610.51332267
130Estrogen signaling pathway_Homo sapiens_hsa049150.49143821
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47595411
132Lysosome_Homo sapiens_hsa041420.47520053
133Renal cell carcinoma_Homo sapiens_hsa052110.47238240
134Caffeine metabolism_Homo sapiens_hsa002320.46507698
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46339480
136Renin-angiotensin system_Homo sapiens_hsa046140.45998180
137Gastric acid secretion_Homo sapiens_hsa049710.45701250
138Serotonergic synapse_Homo sapiens_hsa047260.45298768
139Arachidonic acid metabolism_Homo sapiens_hsa005900.45278942
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45225355
141Mineral absorption_Homo sapiens_hsa049780.45123781
142Bile secretion_Homo sapiens_hsa049760.44260764
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44188827
144GnRH signaling pathway_Homo sapiens_hsa049120.44156813
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.43657089
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42836882
147TNF signaling pathway_Homo sapiens_hsa046680.42596602
148Choline metabolism in cancer_Homo sapiens_hsa052310.40817719
149Arginine and proline metabolism_Homo sapiens_hsa003300.40357115
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39958213
151Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39364518
152Galactose metabolism_Homo sapiens_hsa000520.39247221
153VEGF signaling pathway_Homo sapiens_hsa043700.36593360
154Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35049477

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