Rank | Gene Set | Z-score |
---|---|---|
1 | positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141) | 9.23610008 |
2 | regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139) | 9.23610008 |
3 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339 | 8.38476946 |
4 | negative regulation of metanephros development (GO:0072217) | 5.87592021 |
5 | regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307) | 5.82210925 |
6 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 5.76090673 |
7 | regulation of podosome assembly (GO:0071801) | 5.42563925 |
8 | negative regulation of interleukin-17 production (GO:0032700) | 5.36108888 |
9 | regulation of MHC class II biosynthetic process (GO:0045346) | 5.32289680 |
10 | positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511) | 5.27027128 |
11 | regulation of vitamin D biosynthetic process (GO:0060556) | 5.22472933 |
12 | negative regulation of neurological system process (GO:0031645) | 5.03900950 |
13 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.96180180 |
14 | regulation of interleukin-6 biosynthetic process (GO:0045408) | 4.93665965 |
15 | regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510) | 4.49229623 |
16 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 4.46839694 |
17 | rRNA methylation (GO:0031167) | 4.38572621 |
18 | rRNA modification (GO:0000154) | 4.31418732 |
19 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.25412206 |
20 | positive regulation of steroid biosynthetic process (GO:0010893) | 4.21216513 |
21 | positive regulation of chemokine biosynthetic process (GO:0045080) | 4.18884187 |
22 | regulation of vitamin metabolic process (GO:0030656) | 4.07577409 |
23 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 4.07271335 |
24 | positive regulation of alcohol biosynthetic process (GO:1902932) | 3.96445582 |
25 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.81595874 |
26 | defense response to protozoan (GO:0042832) | 3.81406343 |
27 | positive regulation of muscle cell apoptotic process (GO:0010661) | 3.80693552 |
28 | regulation of secondary heart field cardioblast proliferation (GO:0003266) | 3.77588224 |
29 | regulation of cardioblast proliferation (GO:0003264) | 3.77588224 |
30 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.65659205 |
31 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.65659205 |
32 | protein maturation by protein folding (GO:0022417) | 3.64417748 |
33 | regulation of smooth muscle cell apoptotic process (GO:0034391) | 3.63481324 |
34 | positive regulation of osteoclast differentiation (GO:0045672) | 3.52910179 |
35 | positive regulation of interleukin-12 production (GO:0032735) | 3.50592501 |
36 | positive regulation of phosphatase activity (GO:0010922) | 3.45344132 |
37 | negative regulation of kidney development (GO:0090185) | 3.42947213 |
38 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235 | 3.39500154 |
39 | viral mRNA export from host cell nucleus (GO:0046784) | 3.35824872 |
40 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.35446743 |
41 | maturation of 5.8S rRNA (GO:0000460) | 3.35372129 |
42 | ubiquinone biosynthetic process (GO:0006744) | 3.33957481 |
43 | positive regulation of organelle assembly (GO:1902117) | 3.30325428 |
44 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.29074481 |
45 | positive regulation of interleukin-1 beta production (GO:0032731) | 3.28027286 |
46 | proteasome assembly (GO:0043248) | 3.24409559 |
47 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.23912781 |
48 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 3.23361310 |
49 | alpha-beta T cell activation involved in immune response (GO:0002287) | 3.23361310 |
50 | T cell differentiation involved in immune response (GO:0002292) | 3.23361310 |
51 | positive regulation of isotype switching (GO:0045830) | 3.23210166 |
52 | chaperone-mediated protein transport (GO:0072321) | 3.22715709 |
53 | response to protozoan (GO:0001562) | 3.20377886 |
54 | regulation of nephron tubule epithelial cell differentiation (GO:0072182) | 3.15393651 |
55 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.11308969 |
56 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.09857037 |
57 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.09857037 |
58 | isotype switching (GO:0045190) | 3.09857037 |
59 | protein complex biogenesis (GO:0070271) | 3.08901166 |
60 | positive regulation of DNA recombination (GO:0045911) | 3.07925958 |
61 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.07119446 |
62 | NADH dehydrogenase complex assembly (GO:0010257) | 3.07119446 |
63 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.07119446 |
64 | termination of RNA polymerase III transcription (GO:0006386) | 3.06008007 |
65 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.06008007 |
66 | leukocyte apoptotic process (GO:0071887) | 3.05684002 |
67 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.05619336 |
68 | histone-serine phosphorylation (GO:0035404) | 3.05271851 |
69 | negative regulation of macrophage differentiation (GO:0045650) | 3.01407476 |
70 | pseudouridine synthesis (GO:0001522) | 2.99710980 |
71 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.97790812 |
72 | negative regulation of ligase activity (GO:0051352) | 2.97790812 |
73 | regulation of chemokine biosynthetic process (GO:0045073) | 2.97248262 |
74 | ubiquinone metabolic process (GO:0006743) | 2.96288193 |
75 | negative regulation of glucose import (GO:0046325) | 2.95317034 |
76 | mannosylation (GO:0097502) | 2.94683507 |
77 | positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531) | 2.94635775 |
78 | myeloid dendritic cell differentiation (GO:0043011) | 2.94256642 |
79 | positive regulation of macrophage derived foam cell differentiation (GO:0010744) | 2.91886654 |
80 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.91805537 |
81 | myeloid dendritic cell activation (GO:0001773) | 2.88957204 |
82 | histone mRNA metabolic process (GO:0008334) | 2.88364845 |
83 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 2.87580867 |
84 | positive regulation of interleukin-1 production (GO:0032732) | 2.84663071 |
85 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.83372080 |
86 | cardiac right ventricle morphogenesis (GO:0003215) | 2.82185784 |
87 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.80552396 |
88 | DNA deamination (GO:0045006) | 2.79852666 |
89 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.79846866 |
90 | regulation of epithelial cell differentiation involved in kidney development (GO:2000696) | 2.78512356 |
91 | nucleoside transmembrane transport (GO:1901642) | 2.78256752 |
92 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.75047508 |
93 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.75047508 |
94 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.75047508 |
95 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.73620695 |
96 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.73620695 |
97 | signal peptide processing (GO:0006465) | 2.71383364 |
98 | negative regulation of growth of symbiont in host (GO:0044130) | 2.71194758 |
99 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 2.71194758 |
100 | regulation of growth of symbiont in host (GO:0044126) | 2.71194758 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.28138762 |
2 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 3.67271779 |
3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.46467540 |
4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.40429620 |
5 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.24498241 |
6 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.20864792 |
7 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 3.15546338 |
8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.96948638 |
9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.83449464 |
10 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.70098006 |
11 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.64577651 |
12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.64022685 |
13 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.63981754 |
14 | VDR_22108803_ChIP-Seq_LS180_Human | 2.61918847 |
15 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.35820380 |
16 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.31427350 |
17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.27578405 |
18 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.22513555 |
19 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.18582064 |
20 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.08283658 |
21 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.08247416 |
22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.06770168 |
23 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.00185569 |
24 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.94366970 |
25 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.89797468 |
26 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.89384722 |
27 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.87626247 |
28 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.82522425 |
29 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.81363598 |
30 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.80409699 |
31 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.76112661 |
32 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.71620686 |
33 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.70217268 |
34 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.64543344 |
35 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.62469895 |
36 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.60610386 |
37 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.55866985 |
38 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.55323324 |
39 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.54830620 |
40 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.53194538 |
41 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.53071604 |
42 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.51901968 |
43 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.48509939 |
44 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.47994802 |
45 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.42725674 |
46 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.41350542 |
47 | EWS_26573619_Chip-Seq_HEK293_Human | 1.39662303 |
48 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.38307501 |
49 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.36185770 |
50 | FUS_26573619_Chip-Seq_HEK293_Human | 1.34650496 |
51 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.30543324 |
52 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.18172267 |
53 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.17701090 |
54 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.16591743 |
55 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.15582242 |
56 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.12967906 |
57 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.12635064 |
58 | P300_19829295_ChIP-Seq_ESCs_Human | 1.10269827 |
59 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.09127392 |
60 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.08771720 |
61 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.07500962 |
62 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.06872309 |
63 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.04716022 |
64 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.03302631 |
65 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.02639460 |
66 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.02325017 |
67 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.02030548 |
68 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.01823234 |
69 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.01361536 |
70 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.00345512 |
71 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.97507556 |
72 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.96077151 |
73 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.94729609 |
74 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.94729609 |
75 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.94670387 |
76 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.93463634 |
77 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.93043385 |
78 | E2F7_22180533_ChIP-Seq_HELA_Human | 0.91170053 |
79 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.91144315 |
80 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.90260773 |
81 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.89993062 |
82 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.89756528 |
83 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.89756528 |
84 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.89353942 |
85 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.89167694 |
86 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.88913851 |
87 | GATA3_26560356_Chip-Seq_TH1_Human | 0.88879379 |
88 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.88700482 |
89 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.86824246 |
90 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 0.86789625 |
91 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.86600720 |
92 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.86273192 |
93 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.83280097 |
94 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.83148254 |
95 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.83137790 |
96 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.82764919 |
97 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.82528008 |
98 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 0.81891880 |
99 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.81389491 |
100 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.81379576 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0001873_stomach_inflammation | 6.28084502 |
2 | MP0004782_abnormal_surfactant_physiolog | 4.45481196 |
3 | MP0001835_abnormal_antigen_presentation | 4.33109604 |
4 | MP0010307_abnormal_tumor_latency | 3.45192619 |
5 | MP0006072_abnormal_retinal_apoptosis | 2.99819041 |
6 | MP0001958_emphysema | 2.58105166 |
7 | MP0001529_abnormal_vocalization | 2.55398702 |
8 | MP0003186_abnormal_redox_activity | 2.49569369 |
9 | MP0005671_abnormal_response_to | 2.43128215 |
10 | MP0005646_abnormal_pituitary_gland | 2.41997214 |
11 | MP0003195_calcinosis | 2.38433838 |
12 | MP0003718_maternal_effect | 2.11224806 |
13 | MP0006054_spinal_hemorrhage | 1.99964838 |
14 | MP0000015_abnormal_ear_pigmentation | 1.97072869 |
15 | MP0005551_abnormal_eye_electrophysiolog | 1.95372526 |
16 | MP0005253_abnormal_eye_physiology | 1.93612654 |
17 | MP0008007_abnormal_cellular_replicative | 1.80805974 |
18 | MP0008058_abnormal_DNA_repair | 1.79360598 |
19 | MP0008875_abnormal_xenobiotic_pharmacok | 1.78623930 |
20 | MP0002148_abnormal_hypersensitivity_rea | 1.76804493 |
21 | MP0005220_abnormal_exocrine_pancreas | 1.70174569 |
22 | MP0008877_abnormal_DNA_methylation | 1.67449631 |
23 | MP0008872_abnormal_physiological_respon | 1.63545034 |
24 | MP0002234_abnormal_pharynx_morphology | 1.58950535 |
25 | MP0001881_abnormal_mammary_gland | 1.53887713 |
26 | MP0002405_respiratory_system_inflammati | 1.48729474 |
27 | MP0006036_abnormal_mitochondrial_physio | 1.40339039 |
28 | MP0009333_abnormal_splenocyte_physiolog | 1.38619254 |
29 | MP0003950_abnormal_plasma_membrane | 1.37326750 |
30 | MP0004142_abnormal_muscle_tone | 1.34351380 |
31 | MP0002751_abnormal_autonomic_nervous | 1.33642426 |
32 | MP0003111_abnormal_nucleus_morphology | 1.31740449 |
33 | MP0002653_abnormal_ependyma_morphology | 1.31535953 |
34 | MP0003011_delayed_dark_adaptation | 1.31307324 |
35 | MP0001293_anophthalmia | 1.27355985 |
36 | MP0010094_abnormal_chromosome_stability | 1.25658180 |
37 | MP0001984_abnormal_olfaction | 1.23666743 |
38 | MP0004957_abnormal_blastocyst_morpholog | 1.21793096 |
39 | MP0003880_abnormal_central_pattern | 1.19772160 |
40 | MP0009046_muscle_twitch | 1.16056213 |
41 | MP0002210_abnormal_sex_determination | 1.14895873 |
42 | MP0002693_abnormal_pancreas_physiology | 1.12206711 |
43 | MP0001764_abnormal_homeostasis | 1.11218665 |
44 | MP0001986_abnormal_taste_sensitivity | 1.09756005 |
45 | MP0000631_abnormal_neuroendocrine_gland | 1.08607017 |
46 | MP0005174_abnormal_tail_pigmentation | 1.08512124 |
47 | MP0002095_abnormal_skin_pigmentation | 1.06578880 |
48 | MP0000569_abnormal_digit_pigmentation | 1.05969809 |
49 | MP0009765_abnormal_xenobiotic_induced | 0.99541355 |
50 | MP0002736_abnormal_nociception_after | 0.98734356 |
51 | MP0000427_abnormal_hair_cycle | 0.98396374 |
52 | MP0005000_abnormal_immune_tolerance | 0.97375508 |
53 | MP0005332_abnormal_amino_acid | 0.97050985 |
54 | MP0006276_abnormal_autonomic_nervous | 0.96440830 |
55 | MP0005410_abnormal_fertilization | 0.95852891 |
56 | MP0001800_abnormal_humoral_immune | 0.94563021 |
57 | MP0002282_abnormal_trachea_morphology | 0.94440946 |
58 | MP0001663_abnormal_digestive_system | 0.93025829 |
59 | MP0001188_hyperpigmentation | 0.92245834 |
60 | MP0005391_vision/eye_phenotype | 0.90506349 |
61 | MP0006035_abnormal_mitochondrial_morpho | 0.88945040 |
62 | MP0001968_abnormal_touch/_nociception | 0.86564320 |
63 | MP0001929_abnormal_gametogenesis | 0.85777234 |
64 | MP0001919_abnormal_reproductive_system | 0.85207074 |
65 | MP0003121_genomic_imprinting | 0.84829022 |
66 | MP0005310_abnormal_salivary_gland | 0.80765756 |
67 | MP0003787_abnormal_imprinting | 0.79403333 |
68 | MP0002933_joint_inflammation | 0.79034491 |
69 | MP0004145_abnormal_muscle_electrophysio | 0.78664485 |
70 | MP0000653_abnormal_sex_gland | 0.76898334 |
71 | MP0010030_abnormal_orbit_morphology | 0.75613586 |
72 | MP0005075_abnormal_melanosome_morpholog | 0.75155264 |
73 | MP0009785_altered_susceptibility_to | 0.74548341 |
74 | MP0001270_distended_abdomen | 0.74521844 |
75 | MP0002254_reproductive_system_inflammat | 0.74506282 |
76 | MP0005248_abnormal_Harderian_gland | 0.74281932 |
77 | MP0002249_abnormal_larynx_morphology | 0.74244701 |
78 | MP0008932_abnormal_embryonic_tissue | 0.73877213 |
79 | MP0000613_abnormal_salivary_gland | 0.73415943 |
80 | MP0003122_maternal_imprinting | 0.73275123 |
81 | MP0005395_other_phenotype | 0.73185450 |
82 | MP0001486_abnormal_startle_reflex | 0.73004804 |
83 | MP0008775_abnormal_heart_ventricle | 0.72278511 |
84 | MP0010155_abnormal_intestine_physiology | 0.71498665 |
85 | MP0009745_abnormal_behavioral_response | 0.71325283 |
86 | MP0002019_abnormal_tumor_incidence | 0.68910654 |
87 | MP0005501_abnormal_skin_physiology | 0.67894688 |
88 | MP0002132_abnormal_respiratory_system | 0.67101329 |
89 | MP0001145_abnormal_male_reproductive | 0.64902555 |
90 | MP0001853_heart_inflammation | 0.64307814 |
91 | MP0001905_abnormal_dopamine_level | 0.63874783 |
92 | MP0005387_immune_system_phenotype | 0.63258941 |
93 | MP0001790_abnormal_immune_system | 0.63258941 |
94 | MP0008873_increased_physiological_sensi | 0.63086158 |
95 | MP0005195_abnormal_posterior_eye | 0.61688790 |
96 | MP0006292_abnormal_olfactory_placode | 0.60644279 |
97 | MP0000689_abnormal_spleen_morphology | 0.60178883 |
98 | MP0001324_abnormal_eye_pigmentation | 0.58757889 |
99 | MP0004215_abnormal_myocardial_fiber | 0.57798561 |
100 | MP0003693_abnormal_embryo_hatching | 0.57540410 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Type I transferrin isoform profile (HP:0003642) | 4.85357955 |
2 | Abnormality of the pons (HP:0007361) | 4.56668523 |
3 | Hypoplasia of the pons (HP:0012110) | 4.54762481 |
4 | Acute necrotizing encephalopathy (HP:0006965) | 4.06789840 |
5 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 3.83384306 |
6 | Abnormal protein N-linked glycosylation (HP:0012347) | 3.83384306 |
7 | Abnormal protein glycosylation (HP:0012346) | 3.83384306 |
8 | Abnormal glycosylation (HP:0012345) | 3.83384306 |
9 | Attenuation of retinal blood vessels (HP:0007843) | 3.74069448 |
10 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.58178690 |
11 | Acute encephalopathy (HP:0006846) | 3.56425971 |
12 | Reduced antithrombin III activity (HP:0001976) | 3.43319723 |
13 | Progressive macrocephaly (HP:0004481) | 3.42525221 |
14 | Mitochondrial inheritance (HP:0001427) | 3.35421838 |
15 | Pancreatic cysts (HP:0001737) | 3.35394181 |
16 | Nonimmune hydrops fetalis (HP:0001790) | 3.26775896 |
17 | Increased CSF lactate (HP:0002490) | 3.20855842 |
18 | Pancreatic fibrosis (HP:0100732) | 3.12711603 |
19 | True hermaphroditism (HP:0010459) | 3.09781867 |
20 | Cerebellar dysplasia (HP:0007033) | 2.85776431 |
21 | Type II lissencephaly (HP:0007260) | 2.79785338 |
22 | Spastic paraparesis (HP:0002313) | 2.75262553 |
23 | Aplastic anemia (HP:0001915) | 2.72643413 |
24 | Progressive muscle weakness (HP:0003323) | 2.68818685 |
25 | Hepatocellular necrosis (HP:0001404) | 2.67201485 |
26 | Cerebral edema (HP:0002181) | 2.66412437 |
27 | Stomatitis (HP:0010280) | 2.61934327 |
28 | Inability to walk (HP:0002540) | 2.60371342 |
29 | Hepatic necrosis (HP:0002605) | 2.56312157 |
30 | Optic disc pallor (HP:0000543) | 2.55043378 |
31 | Lipid accumulation in hepatocytes (HP:0006561) | 2.54976562 |
32 | Increased serum lactate (HP:0002151) | 2.50380761 |
33 | Large for gestational age (HP:0001520) | 2.49831842 |
34 | Exertional dyspnea (HP:0002875) | 2.48054948 |
35 | Megaloblastic anemia (HP:0001889) | 2.46030880 |
36 | Tubulointerstitial nephritis (HP:0001970) | 2.42953850 |
37 | Increased hepatocellular lipid droplets (HP:0006565) | 2.42252337 |
38 | Colon cancer (HP:0003003) | 2.38881553 |
39 | Cystic liver disease (HP:0006706) | 2.37975126 |
40 | IgA deficiency (HP:0002720) | 2.37781053 |
41 | Congenital stationary night blindness (HP:0007642) | 2.31711042 |
42 | Abnormality of midbrain morphology (HP:0002418) | 2.30166332 |
43 | Molar tooth sign on MRI (HP:0002419) | 2.30166332 |
44 | Renal Fanconi syndrome (HP:0001994) | 2.28694549 |
45 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.26646977 |
46 | Exercise intolerance (HP:0003546) | 2.25403107 |
47 | Cutaneous melanoma (HP:0012056) | 2.25322135 |
48 | Abnormality of methionine metabolism (HP:0010901) | 2.24815300 |
49 | Hypoglycemic coma (HP:0001325) | 2.22759905 |
50 | Glucose intolerance (HP:0000833) | 2.20527524 |
51 | Renal cortical cysts (HP:0000803) | 2.19323307 |
52 | Medial flaring of the eyebrow (HP:0010747) | 2.15505636 |
53 | Leukodystrophy (HP:0002415) | 2.09727632 |
54 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.08238085 |
55 | Recurrent cutaneous fungal infections (HP:0011370) | 2.08238085 |
56 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.06848252 |
57 | Abnormality of the renal cortex (HP:0011035) | 2.04300270 |
58 | Abnormal albumin level (HP:0012116) | 2.01180135 |
59 | Hypoalbuminemia (HP:0003073) | 2.01180135 |
60 | Respiratory failure (HP:0002878) | 2.00356105 |
61 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.99580697 |
62 | Abolished electroretinogram (ERG) (HP:0000550) | 1.96699657 |
63 | Sclerocornea (HP:0000647) | 1.96238342 |
64 | IgG deficiency (HP:0004315) | 1.96039888 |
65 | Abnormality of homocysteine metabolism (HP:0010919) | 1.95877470 |
66 | Homocystinuria (HP:0002156) | 1.95877470 |
67 | Lethargy (HP:0001254) | 1.90496851 |
68 | Long nose (HP:0003189) | 1.89748545 |
69 | Opisthotonus (HP:0002179) | 1.89696518 |
70 | Abnormality of the proximal phalanges of the hand (HP:0009834) | 1.89602654 |
71 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.88147553 |
72 | Occipital encephalocele (HP:0002085) | 1.86159178 |
73 | Methylmalonic acidemia (HP:0002912) | 1.86071405 |
74 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.85999432 |
75 | Generalized aminoaciduria (HP:0002909) | 1.85377918 |
76 | Lactic acidosis (HP:0003128) | 1.84858099 |
77 | Ketoacidosis (HP:0001993) | 1.84749231 |
78 | Confusion (HP:0001289) | 1.82482239 |
79 | Chronic sinusitis (HP:0011109) | 1.81451564 |
80 | Hypoglycemic seizures (HP:0002173) | 1.78841136 |
81 | Postaxial foot polydactyly (HP:0001830) | 1.78598534 |
82 | Delayed myelination (HP:0012448) | 1.78387887 |
83 | Global brain atrophy (HP:0002283) | 1.77080124 |
84 | Prominent metopic ridge (HP:0005487) | 1.76948174 |
85 | Nephronophthisis (HP:0000090) | 1.76030885 |
86 | Degeneration of anterior horn cells (HP:0002398) | 1.75883011 |
87 | Abnormality of the anterior horn cell (HP:0006802) | 1.75883011 |
88 | Methylmalonic aciduria (HP:0012120) | 1.72710536 |
89 | Curly hair (HP:0002212) | 1.72586245 |
90 | Albinism (HP:0001022) | 1.70752403 |
91 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.69209763 |
92 | Oral leukoplakia (HP:0002745) | 1.68883509 |
93 | Anencephaly (HP:0002323) | 1.68008519 |
94 | Abnormal pancreas size (HP:0012094) | 1.67622993 |
95 | Hyperglycinuria (HP:0003108) | 1.66770747 |
96 | Decreased central vision (HP:0007663) | 1.66523672 |
97 | Gaze-evoked nystagmus (HP:0000640) | 1.65081599 |
98 | Cheilitis (HP:0100825) | 1.64738847 |
99 | Hypokinesia (HP:0002375) | 1.64593678 |
100 | Neutropenia (HP:0001875) | 1.63707486 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BRSK2 | 4.66037097 |
2 | CAMKK2 | 3.97153647 |
3 | FLT3 | 3.75561987 |
4 | STK16 | 3.73866380 |
5 | EIF2AK3 | 3.40423243 |
6 | TXK | 2.95066691 |
7 | VRK2 | 2.67633898 |
8 | TNIK | 2.66201818 |
9 | WNK3 | 2.63379219 |
10 | PKN2 | 2.59877258 |
11 | BMPR1B | 2.58811008 |
12 | NME1 | 2.49301831 |
13 | MST4 | 2.29395075 |
14 | TLK1 | 2.24113631 |
15 | PBK | 2.18435919 |
16 | FRK | 1.98615554 |
17 | BUB1 | 1.98429779 |
18 | VRK1 | 1.93306645 |
19 | BRSK1 | 1.76428513 |
20 | ZAK | 1.68785261 |
21 | CAMKK1 | 1.65119629 |
22 | AKT3 | 1.63020404 |
23 | MKNK2 | 1.58229943 |
24 | PINK1 | 1.50124990 |
25 | OXSR1 | 1.35313571 |
26 | MET | 1.34657797 |
27 | NUAK1 | 1.25601428 |
28 | TSSK6 | 1.24878217 |
29 | TNK2 | 1.19465686 |
30 | MAP2K7 | 1.16263331 |
31 | ADRBK2 | 1.13012102 |
32 | PIK3CG | 1.12623553 |
33 | PASK | 1.12467538 |
34 | IRAK4 | 1.08927061 |
35 | CDC7 | 1.05939874 |
36 | ADRBK1 | 1.01878510 |
37 | TEC | 1.01172006 |
38 | NEK1 | 1.00624953 |
39 | STK38L | 0.99699212 |
40 | IRAK2 | 0.98117648 |
41 | EIF2AK1 | 0.97775663 |
42 | ACVR1B | 0.92662044 |
43 | EIF2AK2 | 0.90647448 |
44 | IRAK1 | 0.85384001 |
45 | PLK3 | 0.83125362 |
46 | MKNK1 | 0.80987024 |
47 | GRK1 | 0.80035958 |
48 | STK39 | 0.79040808 |
49 | CDK8 | 0.77359571 |
50 | WNK1 | 0.73713297 |
51 | PRKD3 | 0.70643819 |
52 | ERBB3 | 0.69503497 |
53 | MAP3K12 | 0.66470331 |
54 | PKN1 | 0.66286619 |
55 | PRKAA2 | 0.59468755 |
56 | TAOK3 | 0.58756824 |
57 | MAP4K2 | 0.57763716 |
58 | KIT | 0.57256098 |
59 | MAP3K4 | 0.55792457 |
60 | STK11 | 0.55771332 |
61 | TTK | 0.53003450 |
62 | PLK1 | 0.52310059 |
63 | ATR | 0.47017221 |
64 | MARK3 | 0.46425196 |
65 | INSRR | 0.45987112 |
66 | CSF1R | 0.44942332 |
67 | WNK4 | 0.44677801 |
68 | CDK3 | 0.43461166 |
69 | CASK | 0.42729254 |
70 | PAK3 | 0.41731161 |
71 | MAP3K7 | 0.41218022 |
72 | NTRK3 | 0.40789439 |
73 | ATM | 0.35842340 |
74 | CSNK1G2 | 0.34605783 |
75 | CSNK1A1 | 0.33936245 |
76 | ITK | 0.32333343 |
77 | PAK6 | 0.32146318 |
78 | CSNK1A1L | 0.31503027 |
79 | CHEK1 | 0.31206599 |
80 | SRPK1 | 0.30552716 |
81 | SYK | 0.30492973 |
82 | BCKDK | 0.29732936 |
83 | TGFBR1 | 0.28180303 |
84 | PHKG1 | 0.27831513 |
85 | PHKG2 | 0.27831513 |
86 | CSNK2A2 | 0.27556620 |
87 | MAP2K6 | 0.26177942 |
88 | CLK1 | 0.25698298 |
89 | CSNK1G1 | 0.23850642 |
90 | PTK2B | 0.23845321 |
91 | PRKCQ | 0.23356959 |
92 | STK24 | 0.23038464 |
93 | CSNK1G3 | 0.22298950 |
94 | CAMK1 | 0.22020321 |
95 | TIE1 | 0.20261315 |
96 | AURKB | 0.19623008 |
97 | ABL1 | 0.19119390 |
98 | IGF1R | 0.18969671 |
99 | PRKCA | 0.18458165 |
100 | STK10 | 0.18440650 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 6.03578457 |
2 | Protein export_Homo sapiens_hsa03060 | 3.66382769 |
3 | Regulation of autophagy_Homo sapiens_hsa04140 | 3.54976703 |
4 | RNA polymerase_Homo sapiens_hsa03020 | 3.02083003 |
5 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.87244897 |
6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.83450172 |
7 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.70738157 |
8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.05865233 |
9 | Parkinsons disease_Homo sapiens_hsa05012 | 1.98318255 |
10 | Homologous recombination_Homo sapiens_hsa03440 | 1.97617229 |
11 | RNA degradation_Homo sapiens_hsa03018 | 1.80803462 |
12 | DNA replication_Homo sapiens_hsa03030 | 1.73039236 |
13 | Phototransduction_Homo sapiens_hsa04744 | 1.55944874 |
14 | Basal transcription factors_Homo sapiens_hsa03022 | 1.53843216 |
15 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.52835970 |
16 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.50882175 |
17 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.50798570 |
18 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.47888042 |
19 | Allograft rejection_Homo sapiens_hsa05330 | 1.47473764 |
20 | Huntingtons disease_Homo sapiens_hsa05016 | 1.44497359 |
21 | Spliceosome_Homo sapiens_hsa03040 | 1.41865730 |
22 | Mismatch repair_Homo sapiens_hsa03430 | 1.40258403 |
23 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.39381824 |
24 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.33075056 |
25 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.31790330 |
26 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.31667428 |
27 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.28472446 |
28 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.28344416 |
29 | Ribosome_Homo sapiens_hsa03010 | 1.25626368 |
30 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.25357200 |
31 | Olfactory transduction_Homo sapiens_hsa04740 | 1.23576300 |
32 | RNA transport_Homo sapiens_hsa03013 | 1.23350423 |
33 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.21955901 |
34 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.21686395 |
35 | Base excision repair_Homo sapiens_hsa03410 | 1.19097539 |
36 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.18313104 |
37 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.10666583 |
38 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.06931241 |
39 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.06027608 |
40 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.05812770 |
41 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.01956655 |
42 | Purine metabolism_Homo sapiens_hsa00230 | 0.99333431 |
43 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.95379605 |
44 | Alzheimers disease_Homo sapiens_hsa05010 | 0.95193022 |
45 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.92769346 |
46 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.92337840 |
47 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.90156708 |
48 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.88682071 |
49 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.87979437 |
50 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.87329894 |
51 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.86645879 |
52 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.83279048 |
53 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.82437299 |
54 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.81252856 |
55 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.78784747 |
56 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.77890060 |
57 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.77664044 |
58 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.76861753 |
59 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.76745510 |
60 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.73829431 |
61 | Sulfur relay system_Homo sapiens_hsa04122 | 0.70385202 |
62 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.68702770 |
63 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.66896909 |
64 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.64848757 |
65 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.64706557 |
66 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.64677757 |
67 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.64310856 |
68 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.64279388 |
69 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.64043200 |
70 | Asthma_Homo sapiens_hsa05310 | 0.62628230 |
71 | Metabolic pathways_Homo sapiens_hsa01100 | 0.61629399 |
72 | Circadian rhythm_Homo sapiens_hsa04710 | 0.60818371 |
73 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.60305158 |
74 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.59811750 |
75 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.58399785 |
76 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.57087487 |
77 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.56180166 |
78 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.54932906 |
79 | Taste transduction_Homo sapiens_hsa04742 | 0.53197199 |
80 | Peroxisome_Homo sapiens_hsa04146 | 0.52100177 |
81 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.51198323 |
82 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.50595809 |
83 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.50455332 |
84 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.48749039 |
85 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.44650659 |
86 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.43028945 |
87 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.41357696 |
88 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.41004447 |
89 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.39293083 |
90 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.38932781 |
91 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.37540605 |
92 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.36298354 |
93 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.36073332 |
94 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.35579828 |
95 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.35576825 |
96 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.34255016 |
97 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.28708876 |
98 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.28107513 |
99 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.26237766 |
100 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.25672313 |