RBMS2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)9.23610008
2regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)9.23610008
3regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033398.38476946
4negative regulation of metanephros development (GO:0072217)5.87592021
5regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.82210925
6regulation of interleukin-12 biosynthetic process (GO:0045075)5.76090673
7regulation of podosome assembly (GO:0071801)5.42563925
8negative regulation of interleukin-17 production (GO:0032700)5.36108888
9regulation of MHC class II biosynthetic process (GO:0045346)5.32289680
10positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)5.27027128
11regulation of vitamin D biosynthetic process (GO:0060556)5.22472933
12negative regulation of neurological system process (GO:0031645)5.03900950
13regulation of isotype switching to IgG isotypes (GO:0048302)4.96180180
14regulation of interleukin-6 biosynthetic process (GO:0045408)4.93665965
15regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.49229623
16positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.46839694
17rRNA methylation (GO:0031167)4.38572621
18rRNA modification (GO:0000154)4.31418732
19positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.25412206
20positive regulation of steroid biosynthetic process (GO:0010893)4.21216513
21positive regulation of chemokine biosynthetic process (GO:0045080)4.18884187
22regulation of vitamin metabolic process (GO:0030656)4.07577409
23regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.07271335
24positive regulation of alcohol biosynthetic process (GO:1902932)3.96445582
25regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.81595874
26defense response to protozoan (GO:0042832)3.81406343
27positive regulation of muscle cell apoptotic process (GO:0010661)3.80693552
28regulation of secondary heart field cardioblast proliferation (GO:0003266)3.77588224
29regulation of cardioblast proliferation (GO:0003264)3.77588224
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.65659205
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.65659205
32protein maturation by protein folding (GO:0022417)3.64417748
33regulation of smooth muscle cell apoptotic process (GO:0034391)3.63481324
34positive regulation of osteoclast differentiation (GO:0045672)3.52910179
35positive regulation of interleukin-12 production (GO:0032735)3.50592501
36positive regulation of phosphatase activity (GO:0010922)3.45344132
37negative regulation of kidney development (GO:0090185)3.42947213
38regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.39500154
39viral mRNA export from host cell nucleus (GO:0046784)3.35824872
40regulation of cellular amino acid metabolic process (GO:0006521)3.35446743
41maturation of 5.8S rRNA (GO:0000460)3.35372129
42ubiquinone biosynthetic process (GO:0006744)3.33957481
43positive regulation of organelle assembly (GO:1902117)3.30325428
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29074481
45positive regulation of interleukin-1 beta production (GO:0032731)3.28027286
46proteasome assembly (GO:0043248)3.24409559
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23912781
48alpha-beta T cell differentiation involved in immune response (GO:0002293)3.23361310
49alpha-beta T cell activation involved in immune response (GO:0002287)3.23361310
50T cell differentiation involved in immune response (GO:0002292)3.23361310
51positive regulation of isotype switching (GO:0045830)3.23210166
52chaperone-mediated protein transport (GO:0072321)3.22715709
53response to protozoan (GO:0001562)3.20377886
54regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.15393651
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11308969
56somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.09857037
57somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.09857037
58isotype switching (GO:0045190)3.09857037
59protein complex biogenesis (GO:0070271)3.08901166
60positive regulation of DNA recombination (GO:0045911)3.07925958
61mitochondrial respiratory chain complex I assembly (GO:0032981)3.07119446
62NADH dehydrogenase complex assembly (GO:0010257)3.07119446
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07119446
64termination of RNA polymerase III transcription (GO:0006386)3.06008007
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.06008007
66leukocyte apoptotic process (GO:0071887)3.05684002
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05619336
68histone-serine phosphorylation (GO:0035404)3.05271851
69negative regulation of macrophage differentiation (GO:0045650)3.01407476
70pseudouridine synthesis (GO:0001522)2.99710980
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97790812
72negative regulation of ligase activity (GO:0051352)2.97790812
73regulation of chemokine biosynthetic process (GO:0045073)2.97248262
74ubiquinone metabolic process (GO:0006743)2.96288193
75negative regulation of glucose import (GO:0046325)2.95317034
76mannosylation (GO:0097502)2.94683507
77positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.94635775
78myeloid dendritic cell differentiation (GO:0043011)2.94256642
79positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.91886654
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91805537
81myeloid dendritic cell activation (GO:0001773)2.88957204
82histone mRNA metabolic process (GO:0008334)2.88364845
83positive regulation of interleukin-1 beta secretion (GO:0050718)2.87580867
84positive regulation of interleukin-1 production (GO:0032732)2.84663071
85dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.83372080
86cardiac right ventricle morphogenesis (GO:0003215)2.82185784
87mitochondrial respiratory chain complex assembly (GO:0033108)2.80552396
88DNA deamination (GO:0045006)2.79852666
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.79846866
90regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.78512356
91nucleoside transmembrane transport (GO:1901642)2.78256752
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.75047508
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.75047508
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.75047508
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.73620695
96signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.73620695
97signal peptide processing (GO:0006465)2.71383364
98negative regulation of growth of symbiont in host (GO:0044130)2.71194758
99negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.71194758
100regulation of growth of symbiont in host (GO:0044126)2.71194758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.28138762
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.67271779
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.46467540
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.40429620
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.24498241
6ZNF274_21170338_ChIP-Seq_K562_Hela3.20864792
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.15546338
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.96948638
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83449464
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70098006
11VDR_23849224_ChIP-Seq_CD4+_Human2.64577651
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64022685
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.63981754
14VDR_22108803_ChIP-Seq_LS180_Human2.61918847
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.35820380
16IGF1R_20145208_ChIP-Seq_DFB_Human2.31427350
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27578405
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22513555
19ELK1_19687146_ChIP-ChIP_HELA_Human2.18582064
20DCP1A_22483619_ChIP-Seq_HELA_Human2.08283658
21FOXP3_21729870_ChIP-Seq_TREG_Human2.08247416
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.06770168
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00185569
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94366970
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.89797468
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.89384722
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87626247
28MYC_18940864_ChIP-ChIP_HL60_Human1.82522425
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.81363598
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.80409699
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76112661
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71620686
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70217268
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.64543344
35IRF1_19129219_ChIP-ChIP_H3396_Human1.62469895
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60610386
37GABP_19822575_ChIP-Seq_HepG2_Human1.55866985
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55323324
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54830620
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53194538
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53071604
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51901968
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48509939
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47994802
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.42725674
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41350542
47EWS_26573619_Chip-Seq_HEK293_Human1.39662303
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38307501
49ER_23166858_ChIP-Seq_MCF-7_Human1.36185770
50FUS_26573619_Chip-Seq_HEK293_Human1.34650496
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30543324
52BCAT_22108803_ChIP-Seq_LS180_Human1.18172267
53HTT_18923047_ChIP-ChIP_STHdh_Human1.17701090
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16591743
55ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15582242
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12967906
57TP53_22573176_ChIP-Seq_HFKS_Human1.12635064
58P300_19829295_ChIP-Seq_ESCs_Human1.10269827
59KDM5A_27292631_Chip-Seq_BREAST_Human1.09127392
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08771720
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.07500962
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.06872309
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04716022
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03302631
65TTF2_22483619_ChIP-Seq_HELA_Human1.02639460
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.02325017
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02030548
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01823234
69LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01361536
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00345512
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97507556
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96077151
73SOX2_19829295_ChIP-Seq_ESCs_Human0.94729609
74NANOG_19829295_ChIP-Seq_ESCs_Human0.94729609
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94670387
76CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93463634
77NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93043385
78E2F7_22180533_ChIP-Seq_HELA_Human0.91170053
79CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91144315
80RBPJ_21746931_ChIP-Seq_IB4_Human0.90260773
81TAF15_26573619_Chip-Seq_HEK293_Human0.89993062
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89756528
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.89756528
84TCF4_22108803_ChIP-Seq_LS180_Human0.89353942
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89167694
86STAT3_18555785_Chip-Seq_ESCs_Mouse0.88913851
87GATA3_26560356_Chip-Seq_TH1_Human0.88879379
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88700482
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86824246
90KLF4_18555785_Chip-Seq_ESCs_Mouse0.86789625
91P300_18555785_Chip-Seq_ESCs_Mouse0.86600720
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86273192
93XRN2_22483619_ChIP-Seq_HELA_Human0.83280097
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83148254
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.83137790
96ETV1_20927104_ChIP-Seq_GIST48_Human0.82764919
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82528008
98SOX2_18555785_Chip-Seq_ESCs_Mouse0.81891880
99MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81389491
100IRF8_22096565_ChIP-ChIP_GC-B_Human0.81379576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation6.28084502
2MP0004782_abnormal_surfactant_physiolog4.45481196
3MP0001835_abnormal_antigen_presentation4.33109604
4MP0010307_abnormal_tumor_latency3.45192619
5MP0006072_abnormal_retinal_apoptosis2.99819041
6MP0001958_emphysema2.58105166
7MP0001529_abnormal_vocalization2.55398702
8MP0003186_abnormal_redox_activity2.49569369
9MP0005671_abnormal_response_to2.43128215
10MP0005646_abnormal_pituitary_gland2.41997214
11MP0003195_calcinosis2.38433838
12MP0003718_maternal_effect2.11224806
13MP0006054_spinal_hemorrhage1.99964838
14MP0000015_abnormal_ear_pigmentation1.97072869
15MP0005551_abnormal_eye_electrophysiolog1.95372526
16MP0005253_abnormal_eye_physiology1.93612654
17MP0008007_abnormal_cellular_replicative1.80805974
18MP0008058_abnormal_DNA_repair1.79360598
19MP0008875_abnormal_xenobiotic_pharmacok1.78623930
20MP0002148_abnormal_hypersensitivity_rea1.76804493
21MP0005220_abnormal_exocrine_pancreas1.70174569
22MP0008877_abnormal_DNA_methylation1.67449631
23MP0008872_abnormal_physiological_respon1.63545034
24MP0002234_abnormal_pharynx_morphology1.58950535
25MP0001881_abnormal_mammary_gland1.53887713
26MP0002405_respiratory_system_inflammati1.48729474
27MP0006036_abnormal_mitochondrial_physio1.40339039
28MP0009333_abnormal_splenocyte_physiolog1.38619254
29MP0003950_abnormal_plasma_membrane1.37326750
30MP0004142_abnormal_muscle_tone1.34351380
31MP0002751_abnormal_autonomic_nervous1.33642426
32MP0003111_abnormal_nucleus_morphology1.31740449
33MP0002653_abnormal_ependyma_morphology1.31535953
34MP0003011_delayed_dark_adaptation1.31307324
35MP0001293_anophthalmia1.27355985
36MP0010094_abnormal_chromosome_stability1.25658180
37MP0001984_abnormal_olfaction1.23666743
38MP0004957_abnormal_blastocyst_morpholog1.21793096
39MP0003880_abnormal_central_pattern1.19772160
40MP0009046_muscle_twitch1.16056213
41MP0002210_abnormal_sex_determination1.14895873
42MP0002693_abnormal_pancreas_physiology1.12206711
43MP0001764_abnormal_homeostasis1.11218665
44MP0001986_abnormal_taste_sensitivity1.09756005
45MP0000631_abnormal_neuroendocrine_gland1.08607017
46MP0005174_abnormal_tail_pigmentation1.08512124
47MP0002095_abnormal_skin_pigmentation1.06578880
48MP0000569_abnormal_digit_pigmentation1.05969809
49MP0009765_abnormal_xenobiotic_induced0.99541355
50MP0002736_abnormal_nociception_after0.98734356
51MP0000427_abnormal_hair_cycle0.98396374
52MP0005000_abnormal_immune_tolerance0.97375508
53MP0005332_abnormal_amino_acid0.97050985
54MP0006276_abnormal_autonomic_nervous0.96440830
55MP0005410_abnormal_fertilization0.95852891
56MP0001800_abnormal_humoral_immune0.94563021
57MP0002282_abnormal_trachea_morphology0.94440946
58MP0001663_abnormal_digestive_system0.93025829
59MP0001188_hyperpigmentation0.92245834
60MP0005391_vision/eye_phenotype0.90506349
61MP0006035_abnormal_mitochondrial_morpho0.88945040
62MP0001968_abnormal_touch/_nociception0.86564320
63MP0001929_abnormal_gametogenesis0.85777234
64MP0001919_abnormal_reproductive_system0.85207074
65MP0003121_genomic_imprinting0.84829022
66MP0005310_abnormal_salivary_gland0.80765756
67MP0003787_abnormal_imprinting0.79403333
68MP0002933_joint_inflammation0.79034491
69MP0004145_abnormal_muscle_electrophysio0.78664485
70MP0000653_abnormal_sex_gland0.76898334
71MP0010030_abnormal_orbit_morphology0.75613586
72MP0005075_abnormal_melanosome_morpholog0.75155264
73MP0009785_altered_susceptibility_to0.74548341
74MP0001270_distended_abdomen0.74521844
75MP0002254_reproductive_system_inflammat0.74506282
76MP0005248_abnormal_Harderian_gland0.74281932
77MP0002249_abnormal_larynx_morphology0.74244701
78MP0008932_abnormal_embryonic_tissue0.73877213
79MP0000613_abnormal_salivary_gland0.73415943
80MP0003122_maternal_imprinting0.73275123
81MP0005395_other_phenotype0.73185450
82MP0001486_abnormal_startle_reflex0.73004804
83MP0008775_abnormal_heart_ventricle0.72278511
84MP0010155_abnormal_intestine_physiology0.71498665
85MP0009745_abnormal_behavioral_response0.71325283
86MP0002019_abnormal_tumor_incidence0.68910654
87MP0005501_abnormal_skin_physiology0.67894688
88MP0002132_abnormal_respiratory_system0.67101329
89MP0001145_abnormal_male_reproductive0.64902555
90MP0001853_heart_inflammation0.64307814
91MP0001905_abnormal_dopamine_level0.63874783
92MP0005387_immune_system_phenotype0.63258941
93MP0001790_abnormal_immune_system0.63258941
94MP0008873_increased_physiological_sensi0.63086158
95MP0005195_abnormal_posterior_eye0.61688790
96MP0006292_abnormal_olfactory_placode0.60644279
97MP0000689_abnormal_spleen_morphology0.60178883
98MP0001324_abnormal_eye_pigmentation0.58757889
99MP0004215_abnormal_myocardial_fiber0.57798561
100MP0003693_abnormal_embryo_hatching0.57540410

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)4.85357955
2Abnormality of the pons (HP:0007361)4.56668523
3Hypoplasia of the pons (HP:0012110)4.54762481
4Acute necrotizing encephalopathy (HP:0006965)4.06789840
5Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.83384306
6Abnormal protein N-linked glycosylation (HP:0012347)3.83384306
7Abnormal protein glycosylation (HP:0012346)3.83384306
8Abnormal glycosylation (HP:0012345)3.83384306
9Attenuation of retinal blood vessels (HP:0007843)3.74069448
10Abnormal mitochondria in muscle tissue (HP:0008316)3.58178690
11Acute encephalopathy (HP:0006846)3.56425971
12Reduced antithrombin III activity (HP:0001976)3.43319723
13Progressive macrocephaly (HP:0004481)3.42525221
14Mitochondrial inheritance (HP:0001427)3.35421838
15Pancreatic cysts (HP:0001737)3.35394181
16Nonimmune hydrops fetalis (HP:0001790)3.26775896
17Increased CSF lactate (HP:0002490)3.20855842
18Pancreatic fibrosis (HP:0100732)3.12711603
19True hermaphroditism (HP:0010459)3.09781867
20Cerebellar dysplasia (HP:0007033)2.85776431
21Type II lissencephaly (HP:0007260)2.79785338
22Spastic paraparesis (HP:0002313)2.75262553
23Aplastic anemia (HP:0001915)2.72643413
24Progressive muscle weakness (HP:0003323)2.68818685
25Hepatocellular necrosis (HP:0001404)2.67201485
26Cerebral edema (HP:0002181)2.66412437
27Stomatitis (HP:0010280)2.61934327
28Inability to walk (HP:0002540)2.60371342
29Hepatic necrosis (HP:0002605)2.56312157
30Optic disc pallor (HP:0000543)2.55043378
31Lipid accumulation in hepatocytes (HP:0006561)2.54976562
32Increased serum lactate (HP:0002151)2.50380761
33Large for gestational age (HP:0001520)2.49831842
34Exertional dyspnea (HP:0002875)2.48054948
35Megaloblastic anemia (HP:0001889)2.46030880
36Tubulointerstitial nephritis (HP:0001970)2.42953850
37Increased hepatocellular lipid droplets (HP:0006565)2.42252337
38Colon cancer (HP:0003003)2.38881553
39Cystic liver disease (HP:0006706)2.37975126
40IgA deficiency (HP:0002720)2.37781053
41Congenital stationary night blindness (HP:0007642)2.31711042
42Abnormality of midbrain morphology (HP:0002418)2.30166332
43Molar tooth sign on MRI (HP:0002419)2.30166332
44Renal Fanconi syndrome (HP:0001994)2.28694549
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26646977
46Exercise intolerance (HP:0003546)2.25403107
47Cutaneous melanoma (HP:0012056)2.25322135
48Abnormality of methionine metabolism (HP:0010901)2.24815300
49Hypoglycemic coma (HP:0001325)2.22759905
50Glucose intolerance (HP:0000833)2.20527524
51Renal cortical cysts (HP:0000803)2.19323307
52Medial flaring of the eyebrow (HP:0010747)2.15505636
53Leukodystrophy (HP:0002415)2.09727632
54Chronic mucocutaneous candidiasis (HP:0002728)2.08238085
55Recurrent cutaneous fungal infections (HP:0011370)2.08238085
56Abnormal rod and cone electroretinograms (HP:0008323)2.06848252
57Abnormality of the renal cortex (HP:0011035)2.04300270
58Abnormal albumin level (HP:0012116)2.01180135
59Hypoalbuminemia (HP:0003073)2.01180135
60Respiratory failure (HP:0002878)2.00356105
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99580697
62Abolished electroretinogram (ERG) (HP:0000550)1.96699657
63Sclerocornea (HP:0000647)1.96238342
64IgG deficiency (HP:0004315)1.96039888
65Abnormality of homocysteine metabolism (HP:0010919)1.95877470
66Homocystinuria (HP:0002156)1.95877470
67Lethargy (HP:0001254)1.90496851
68Long nose (HP:0003189)1.89748545
69Opisthotonus (HP:0002179)1.89696518
70Abnormality of the proximal phalanges of the hand (HP:0009834)1.89602654
71Pancreatic islet-cell hyperplasia (HP:0004510)1.88147553
72Occipital encephalocele (HP:0002085)1.86159178
73Methylmalonic acidemia (HP:0002912)1.86071405
74Hyperinsulinemic hypoglycemia (HP:0000825)1.85999432
75Generalized aminoaciduria (HP:0002909)1.85377918
76Lactic acidosis (HP:0003128)1.84858099
77Ketoacidosis (HP:0001993)1.84749231
78Confusion (HP:0001289)1.82482239
79Chronic sinusitis (HP:0011109)1.81451564
80Hypoglycemic seizures (HP:0002173)1.78841136
81Postaxial foot polydactyly (HP:0001830)1.78598534
82Delayed myelination (HP:0012448)1.78387887
83Global brain atrophy (HP:0002283)1.77080124
84Prominent metopic ridge (HP:0005487)1.76948174
85Nephronophthisis (HP:0000090)1.76030885
86Degeneration of anterior horn cells (HP:0002398)1.75883011
87Abnormality of the anterior horn cell (HP:0006802)1.75883011
88Methylmalonic aciduria (HP:0012120)1.72710536
89Curly hair (HP:0002212)1.72586245
90Albinism (HP:0001022)1.70752403
91Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69209763
92Oral leukoplakia (HP:0002745)1.68883509
93Anencephaly (HP:0002323)1.68008519
94Abnormal pancreas size (HP:0012094)1.67622993
95Hyperglycinuria (HP:0003108)1.66770747
96Decreased central vision (HP:0007663)1.66523672
97Gaze-evoked nystagmus (HP:0000640)1.65081599
98Cheilitis (HP:0100825)1.64738847
99Hypokinesia (HP:0002375)1.64593678
100Neutropenia (HP:0001875)1.63707486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK24.66037097
2CAMKK23.97153647
3FLT33.75561987
4STK163.73866380
5EIF2AK33.40423243
6TXK2.95066691
7VRK22.67633898
8TNIK2.66201818
9WNK32.63379219
10PKN22.59877258
11BMPR1B2.58811008
12NME12.49301831
13MST42.29395075
14TLK12.24113631
15PBK2.18435919
16FRK1.98615554
17BUB11.98429779
18VRK11.93306645
19BRSK11.76428513
20ZAK1.68785261
21CAMKK11.65119629
22AKT31.63020404
23MKNK21.58229943
24PINK11.50124990
25OXSR11.35313571
26MET1.34657797
27NUAK11.25601428
28TSSK61.24878217
29TNK21.19465686
30MAP2K71.16263331
31ADRBK21.13012102
32PIK3CG1.12623553
33PASK1.12467538
34IRAK41.08927061
35CDC71.05939874
36ADRBK11.01878510
37TEC1.01172006
38NEK11.00624953
39STK38L0.99699212
40IRAK20.98117648
41EIF2AK10.97775663
42ACVR1B0.92662044
43EIF2AK20.90647448
44IRAK10.85384001
45PLK30.83125362
46MKNK10.80987024
47GRK10.80035958
48STK390.79040808
49CDK80.77359571
50WNK10.73713297
51PRKD30.70643819
52ERBB30.69503497
53MAP3K120.66470331
54PKN10.66286619
55PRKAA20.59468755
56TAOK30.58756824
57MAP4K20.57763716
58KIT0.57256098
59MAP3K40.55792457
60STK110.55771332
61TTK0.53003450
62PLK10.52310059
63ATR0.47017221
64MARK30.46425196
65INSRR0.45987112
66CSF1R0.44942332
67WNK40.44677801
68CDK30.43461166
69CASK0.42729254
70PAK30.41731161
71MAP3K70.41218022
72NTRK30.40789439
73ATM0.35842340
74CSNK1G20.34605783
75CSNK1A10.33936245
76ITK0.32333343
77PAK60.32146318
78CSNK1A1L0.31503027
79CHEK10.31206599
80SRPK10.30552716
81SYK0.30492973
82BCKDK0.29732936
83TGFBR10.28180303
84PHKG10.27831513
85PHKG20.27831513
86CSNK2A20.27556620
87MAP2K60.26177942
88CLK10.25698298
89CSNK1G10.23850642
90PTK2B0.23845321
91PRKCQ0.23356959
92STK240.23038464
93CSNK1G30.22298950
94CAMK10.22020321
95TIE10.20261315
96AURKB0.19623008
97ABL10.19119390
98IGF1R0.18969671
99PRKCA0.18458165
100STK100.18440650

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030506.03578457
2Protein export_Homo sapiens_hsa030603.66382769
3Regulation of autophagy_Homo sapiens_hsa041403.54976703
4RNA polymerase_Homo sapiens_hsa030203.02083003
5Butanoate metabolism_Homo sapiens_hsa006502.87244897
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83450172
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.70738157
8Oxidative phosphorylation_Homo sapiens_hsa001902.05865233
9Parkinsons disease_Homo sapiens_hsa050121.98318255
10Homologous recombination_Homo sapiens_hsa034401.97617229
11RNA degradation_Homo sapiens_hsa030181.80803462
12DNA replication_Homo sapiens_hsa030301.73039236
13Phototransduction_Homo sapiens_hsa047441.55944874
14Basal transcription factors_Homo sapiens_hsa030221.53843216
15Pyrimidine metabolism_Homo sapiens_hsa002401.52835970
16Steroid biosynthesis_Homo sapiens_hsa001001.50882175
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50798570
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47888042
19Allograft rejection_Homo sapiens_hsa053301.47473764
20Huntingtons disease_Homo sapiens_hsa050161.44497359
21Spliceosome_Homo sapiens_hsa030401.41865730
22Mismatch repair_Homo sapiens_hsa034301.40258403
23Rheumatoid arthritis_Homo sapiens_hsa053231.39381824
24Linoleic acid metabolism_Homo sapiens_hsa005911.33075056
25One carbon pool by folate_Homo sapiens_hsa006701.31790330
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31667428
27Propanoate metabolism_Homo sapiens_hsa006401.28472446
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28344416
29Ribosome_Homo sapiens_hsa030101.25626368
30Type I diabetes mellitus_Homo sapiens_hsa049401.25357200
31Olfactory transduction_Homo sapiens_hsa047401.23576300
32RNA transport_Homo sapiens_hsa030131.23350423
33African trypanosomiasis_Homo sapiens_hsa051431.21955901
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21686395
35Base excision repair_Homo sapiens_hsa034101.19097539
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18313104
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10666583
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.06931241
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06027608
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05812770
41Nucleotide excision repair_Homo sapiens_hsa034201.01956655
42Purine metabolism_Homo sapiens_hsa002300.99333431
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95379605
44Alzheimers disease_Homo sapiens_hsa050100.95193022
45TGF-beta signaling pathway_Homo sapiens_hsa043500.92769346
46Vitamin B6 metabolism_Homo sapiens_hsa007500.92337840
47Fanconi anemia pathway_Homo sapiens_hsa034600.90156708
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88682071
49Non-homologous end-joining_Homo sapiens_hsa034500.87979437
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87329894
51Graft-versus-host disease_Homo sapiens_hsa053320.86645879
52Systemic lupus erythematosus_Homo sapiens_hsa053220.83279048
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.82437299
54N-Glycan biosynthesis_Homo sapiens_hsa005100.81252856
55Fatty acid elongation_Homo sapiens_hsa000620.78784747
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.77890060
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77664044
58Nitrogen metabolism_Homo sapiens_hsa009100.76861753
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76745510
60Tryptophan metabolism_Homo sapiens_hsa003800.73829431
61Sulfur relay system_Homo sapiens_hsa041220.70385202
62beta-Alanine metabolism_Homo sapiens_hsa004100.68702770
63Ether lipid metabolism_Homo sapiens_hsa005650.66896909
64Pyruvate metabolism_Homo sapiens_hsa006200.64848757
65Primary immunodeficiency_Homo sapiens_hsa053400.64706557
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64677757
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64310856
68Folate biosynthesis_Homo sapiens_hsa007900.64279388
69Fatty acid degradation_Homo sapiens_hsa000710.64043200
70Asthma_Homo sapiens_hsa053100.62628230
71Metabolic pathways_Homo sapiens_hsa011000.61629399
72Circadian rhythm_Homo sapiens_hsa047100.60818371
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60305158
74Glutathione metabolism_Homo sapiens_hsa004800.59811750
75Antigen processing and presentation_Homo sapiens_hsa046120.58399785
76Fructose and mannose metabolism_Homo sapiens_hsa000510.57087487
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56180166
78Fat digestion and absorption_Homo sapiens_hsa049750.54932906
79Taste transduction_Homo sapiens_hsa047420.53197199
80Peroxisome_Homo sapiens_hsa041460.52100177
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51198323
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.50595809
83Arachidonic acid metabolism_Homo sapiens_hsa005900.50455332
84Fatty acid metabolism_Homo sapiens_hsa012120.48749039
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44650659
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.43028945
87Hematopoietic cell lineage_Homo sapiens_hsa046400.41357696
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41004447
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.39293083
90Selenocompound metabolism_Homo sapiens_hsa004500.38932781
91Epstein-Barr virus infection_Homo sapiens_hsa051690.37540605
92Caffeine metabolism_Homo sapiens_hsa002320.36298354
93Vitamin digestion and absorption_Homo sapiens_hsa049770.36073332
94Tyrosine metabolism_Homo sapiens_hsa003500.35579828
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35576825
96Cardiac muscle contraction_Homo sapiens_hsa042600.34255016
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28708876
98Ovarian steroidogenesis_Homo sapiens_hsa049130.28107513
99T cell receptor signaling pathway_Homo sapiens_hsa046600.26237766
100Autoimmune thyroid disease_Homo sapiens_hsa053200.25672313

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