RBMX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified. A snoRNA gene (SNORD61) is found in one of its introns. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.44925919
2mitotic sister chromatid segregation (GO:0000070)4.40122809
3kinetochore organization (GO:0051383)4.27907227
4histone exchange (GO:0043486)4.24363480
5DNA replication checkpoint (GO:0000076)4.21497544
6protein localization to chromosome, centromeric region (GO:0071459)4.15931268
7kinetochore assembly (GO:0051382)4.13379064
8nuclear pore organization (GO:0006999)4.11099741
9DNA strand elongation involved in DNA replication (GO:0006271)4.05864579
10DNA strand elongation (GO:0022616)3.90711951
11DNA replication-dependent nucleosome assembly (GO:0006335)3.88119118
12DNA replication-dependent nucleosome organization (GO:0034723)3.88119118
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.83588666
14regulation of centriole replication (GO:0046599)3.83024676
15response to pheromone (GO:0019236)3.78210328
16telomere maintenance via semi-conservative replication (GO:0032201)3.76119675
17establishment of integrated proviral latency (GO:0075713)3.75487080
18mitotic sister chromatid cohesion (GO:0007064)3.74678427
19positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.66331479
20mitotic chromosome condensation (GO:0007076)3.54808334
21* negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.53186304
22histone H2A acetylation (GO:0043968)3.50963165
23mRNA splice site selection (GO:0006376)3.50012648
24protein-DNA complex disassembly (GO:0032986)3.45228060
25nucleosome disassembly (GO:0006337)3.45228060
26regulation of DNA endoreduplication (GO:0032875)3.42411834
27somatic hypermutation of immunoglobulin genes (GO:0016446)3.39551257
28somatic diversification of immune receptors via somatic mutation (GO:0002566)3.39551257
29attachment of spindle microtubules to kinetochore (GO:0008608)3.36521011
30* negative regulation of RNA splicing (GO:0033119)3.34531289
31regulation of centrosome cycle (GO:0046605)3.33624852
32telomere maintenance via recombination (GO:0000722)3.33453759
33mitotic nuclear envelope disassembly (GO:0007077)3.30146028
34spindle assembly checkpoint (GO:0071173)3.28797973
35microtubule depolymerization (GO:0007019)3.28411625
36IMP biosynthetic process (GO:0006188)3.25587258
37regulation of helicase activity (GO:0051095)3.24375320
38central nervous system projection neuron axonogenesis (GO:0021952)3.23438671
39mitotic spindle assembly checkpoint (GO:0007094)3.23395953
40non-recombinational repair (GO:0000726)3.20854639
41double-strand break repair via nonhomologous end joining (GO:0006303)3.20854639
42regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18027801
43regulation of mitotic spindle checkpoint (GO:1903504)3.18027801
44negative regulation of mitotic sister chromatid separation (GO:2000816)3.17750437
45negative regulation of mitotic sister chromatid segregation (GO:0033048)3.17750437
46negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.17750437
47negative regulation of sister chromatid segregation (GO:0033046)3.17750437
48DNA topological change (GO:0006265)3.17670591
49chromatin assembly or disassembly (GO:0006333)3.16471807
50pore complex assembly (GO:0046931)3.14967222
51mitotic G2/M transition checkpoint (GO:0044818)3.13302201
52peptidyl-lysine trimethylation (GO:0018023)3.12960128
53histone H3-K4 trimethylation (GO:0080182)3.11418443
54purine nucleobase biosynthetic process (GO:0009113)3.11329557
55viral mRNA export from host cell nucleus (GO:0046784)3.10578169
56negative regulation of DNA recombination (GO:0045910)3.09644407
57negative regulation of DNA-dependent DNA replication (GO:2000104)3.08754074
58chromosome segregation (GO:0007059)3.08312128
59negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04644617
60* regulation of mRNA splicing, via spliceosome (GO:0048024)3.04463083
61membrane disassembly (GO:0030397)3.04045289
62nuclear envelope disassembly (GO:0051081)3.04045289
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.03972371
64negative regulation of chromosome segregation (GO:0051985)3.03914377
65nucleobase biosynthetic process (GO:0046112)3.02715750
66centriole replication (GO:0007099)3.02377833
67DNA replication initiation (GO:0006270)3.01117230
68maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00746806
69histone H3-K9 methylation (GO:0051567)3.00002527
70regulation of spindle organization (GO:0090224)2.98271219
71DNA damage response, detection of DNA damage (GO:0042769)2.98110348
72telomere maintenance via telomere lengthening (GO:0010833)2.97889931
73spindle checkpoint (GO:0031577)2.96776759
74cerebral cortex radially oriented cell migration (GO:0021799)2.95569827
75resolution of meiotic recombination intermediates (GO:0000712)2.93119287
76positive regulation of chromosome segregation (GO:0051984)2.91265148
77DNA replication-independent nucleosome assembly (GO:0006336)2.90856866
78DNA replication-independent nucleosome organization (GO:0034724)2.90856866
79histone deubiquitination (GO:0016578)2.90696876
80regulation of mitotic sister chromatid separation (GO:0010965)2.90622865
81regulation of mitotic sister chromatid segregation (GO:0033047)2.90622865
82regulation of sister chromatid segregation (GO:0033045)2.90622865
83heterochromatin organization (GO:0070828)2.90263010
84regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89036745
85DNA catabolic process, exonucleolytic (GO:0000738)2.88711845
86kidney morphogenesis (GO:0060993)2.88701225
87regulation of centrosome duplication (GO:0010824)2.88490372
88protein prenylation (GO:0018342)2.88449452
89prenylation (GO:0097354)2.88449452
90regulation of sister chromatid cohesion (GO:0007063)2.88309407
91pyrimidine nucleobase catabolic process (GO:0006208)2.87097709
92mitotic spindle checkpoint (GO:0071174)2.86893465
93CENP-A containing nucleosome assembly (GO:0034080)2.86823165
94DNA ligation (GO:0006266)2.86300134
95IMP metabolic process (GO:0046040)2.85680545
96dentate gyrus development (GO:0021542)2.84741511
97* negative regulation of mRNA processing (GO:0050686)2.83232074
98pre-miRNA processing (GO:0031054)2.82827496
99DNA unwinding involved in DNA replication (GO:0006268)2.82151194
100protein K11-linked ubiquitination (GO:0070979)2.81517861
101protein localization to chromosome (GO:0034502)2.81434574
102interkinetic nuclear migration (GO:0022027)2.79865292
103mesenchymal cell differentiation involved in renal system development (GO:2001012)2.79844770
104mesenchymal cell differentiation involved in kidney development (GO:0072161)2.79844770
105regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.79562105
106facial nerve structural organization (GO:0021612)2.78349671
107ATP-dependent chromatin remodeling (GO:0043044)2.77662258
108positive regulation of DNA-dependent DNA replication (GO:2000105)2.76948928
109sister chromatid segregation (GO:0000819)2.75043970
110DNA double-strand break processing (GO:0000729)2.74263019
111regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73234042
112DNA strand renaturation (GO:0000733)2.69636120
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67576422
114V(D)J recombination (GO:0033151)2.66736290
115negative regulation of mitosis (GO:0045839)2.66686925
116chromatin remodeling at centromere (GO:0031055)2.66489362
117negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.65201761
118regulation of respiratory system process (GO:0044065)2.64088502
119cell differentiation involved in metanephros development (GO:0072202)2.63128226
120generation of neurons (GO:0048699)2.60852540
121cell proliferation in forebrain (GO:0021846)2.59753101
122* regulation of RNA splicing (GO:0043484)2.59695112
123regulation of nuclear cell cycle DNA replication (GO:0033262)2.57613551
124* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.57508400
125* mRNA splicing, via spliceosome (GO:0000398)2.57508400
126regulation of chromosome segregation (GO:0051983)2.57141019
127postsynaptic membrane organization (GO:0001941)2.53260722
128regulation of DNA damage checkpoint (GO:2000001)2.53179961
129metaphase plate congression (GO:0051310)2.51783096
130DNA demethylation (GO:0080111)2.51442137
131dosage compensation (GO:0007549)2.50925632
132* RNA splicing, via transesterification reactions (GO:0000375)2.50335667
133limb bud formation (GO:0060174)2.50273721
134mitotic metaphase plate congression (GO:0007080)2.49440549
135cell proliferation involved in metanephros development (GO:0072203)2.49368483
136replication fork processing (GO:0031297)2.48026429
137glial cell proliferation (GO:0014009)2.45340120
138somite development (GO:0061053)2.44826474
139positive regulation of histone H3-K4 methylation (GO:0051571)2.43601005
140regulation of telomere maintenance (GO:0032204)2.43577499
141termination of RNA polymerase II transcription (GO:0006369)2.43543975
142mismatch repair (GO:0006298)2.43362656
143protein localization to kinetochore (GO:0034501)2.42509436
144microtubule nucleation (GO:0007020)2.42372701
145central nervous system neuron axonogenesis (GO:0021955)2.41836179
146negative regulation of axon guidance (GO:1902668)2.41742227
147axonal fasciculation (GO:0007413)2.40214682
148establishment of chromosome localization (GO:0051303)2.40134909
149mitotic recombination (GO:0006312)2.38375105
150proximal/distal pattern formation (GO:0009954)2.37564150
151regulation of mesenchymal cell apoptotic process (GO:2001053)2.37167139
152sympathetic nervous system development (GO:0048485)2.36113150
153cranial nerve structural organization (GO:0021604)2.35829944
154cell differentiation involved in kidney development (GO:0061005)2.33998848
155DNA integration (GO:0015074)2.33722005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.42052912
2E2F7_22180533_ChIP-Seq_HELA_Human5.41208263
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.70937419
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.86476872
5EZH2_22144423_ChIP-Seq_EOC_Human3.34306230
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.18191385
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09433166
8GBX2_23144817_ChIP-Seq_PC3_Human2.74027946
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.70159736
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62374057
11* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45667292
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45592181
13CIITA_25753668_ChIP-Seq_RAJI_Human2.35013088
14YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33678503
15AR_21909140_ChIP-Seq_LNCAP_Human2.26395947
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24720145
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24106328
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20007276
19IGF1R_20145208_ChIP-Seq_DFB_Human2.18865529
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16600993
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.13480094
22* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09939253
23* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07847337
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.99719524
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.94978408
26* VDR_23849224_ChIP-Seq_CD4+_Human1.94403062
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.92794729
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89204437
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87949750
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84363098
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.83377550
32* TTF2_22483619_ChIP-Seq_HELA_Human1.83322987
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76799331
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76741832
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.72490363
36EWS_26573619_Chip-Seq_HEK293_Human1.72281268
37* XRN2_22483619_ChIP-Seq_HELA_Human1.72100590
38FUS_26573619_Chip-Seq_HEK293_Human1.71767018
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.69388013
40DCP1A_22483619_ChIP-Seq_HELA_Human1.67194542
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67137285
42MYC_18940864_ChIP-ChIP_HL60_Human1.64737409
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62393078
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61479865
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60889675
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57175490
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54533510
48NANOG_16153702_ChIP-ChIP_HESCs_Human1.52072234
49ZNF274_21170338_ChIP-Seq_K562_Hela1.48873878
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.48058677
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.47931329
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47883930
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47445323
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45639244
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45546899
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.44822580
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43627440
58* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42120774
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40911540
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38381096
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36355385
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35482284
63VDR_22108803_ChIP-Seq_LS180_Human1.33837484
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31818069
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31423210
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27888711
67SOX9_26525672_Chip-Seq_HEART_Mouse1.26229323
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25196023
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.24916262
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24720495
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22683216
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.21315258
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21080202
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20093315
75* IRF1_19129219_ChIP-ChIP_H3396_Human1.19584177
76GABP_19822575_ChIP-Seq_HepG2_Human1.17458141
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17034034
78RNF2_27304074_Chip-Seq_NSC_Mouse1.16915294
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16909422
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16909422
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16702217
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15512139
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.15009374
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14779299
85* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13384416
86ELK1_19687146_ChIP-ChIP_HELA_Human1.13378649
87RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12463477
88EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12463477
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12337303
90P300_19829295_ChIP-Seq_ESCs_Human1.11882759
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11502496
92* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11360793
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09649994
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08670433
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08644083
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08643126
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08632585
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08329862
99EST1_17652178_ChIP-ChIP_JURKAT_Human1.08086774
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07719948
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05944300
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03552832
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.01881230
104CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01447439
105SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01320357
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00973136
107KDM5A_27292631_Chip-Seq_BREAST_Human1.00254737
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00052876
109LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99525691
110NANOG_18555785_Chip-Seq_ESCs_Mouse0.98151732
111SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97900933
112EZH2_27294783_Chip-Seq_ESCs_Mouse0.97605173
113SRF_21415370_ChIP-Seq_HL-1_Mouse0.96367060
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95102263
115SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94285493
116P53_22387025_ChIP-Seq_ESCs_Mouse0.93943060
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93319433
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92793530
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92140749
120NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91645437
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90129943
122KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90129943
123KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90129943
124CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89835855
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89830559
126* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88697811
127FLI1_27457419_Chip-Seq_LIVER_Mouse0.88652033
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.88619577
129PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86152163
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86143729
131TAF15_26573619_Chip-Seq_HEK293_Human0.86096274
132E2F1_18555785_Chip-Seq_ESCs_Mouse0.85382590
133MYC_22102868_ChIP-Seq_BL_Human0.84755806
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83713138
135FOXP3_21729870_ChIP-Seq_TREG_Human0.82946699
136YY1_21170310_ChIP-Seq_MESCs_Mouse0.82427189
137YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82389542
138MYC_18555785_ChIP-Seq_MESCs_Mouse0.82347137
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81810522
140SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80588645
141SMAD4_21799915_ChIP-Seq_A2780_Human0.80249980
142* SOX17_20123909_ChIP-Seq_XEN_Mouse0.77246852
143* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.76569309
144POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.74345434
145FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.73891511
146* NANOG_21062744_ChIP-ChIP_HESCs_Human0.73749466
147NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.71546073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.32537227
2MP0006292_abnormal_olfactory_placode2.90635726
3MP0003787_abnormal_imprinting2.62010622
4MP0000566_synostosis2.55730203
5MP0003122_maternal_imprinting2.51340683
6MP0003121_genomic_imprinting2.45965664
7MP0010094_abnormal_chromosome_stability2.26121265
8MP0003111_abnormal_nucleus_morphology2.21786271
9MP0002938_white_spotting2.20149976
10MP0000778_abnormal_nervous_system2.15482636
11MP0003567_abnormal_fetal_cardiomyocyte2.00393468
12MP0005423_abnormal_somatic_nervous1.91449248
13MP0002102_abnormal_ear_morphology1.91418956
14MP0003385_abnormal_body_wall1.90412206
15MP0001188_hyperpigmentation1.90378278
16MP0008007_abnormal_cellular_replicative1.90352711
17MP0008877_abnormal_DNA_methylation1.89718535
18MP0008058_abnormal_DNA_repair1.86986118
19MP0000049_abnormal_middle_ear1.85944132
20MP0003938_abnormal_ear_development1.79859921
21MP0003942_abnormal_urinary_system1.70179450
22MP0003077_abnormal_cell_cycle1.66645040
23MP0008057_abnormal_DNA_replication1.66177922
24MP0008789_abnormal_olfactory_epithelium1.58825821
25MP0000631_abnormal_neuroendocrine_gland1.58042648
26MP0002009_preneoplasia1.57751482
27MP0010030_abnormal_orbit_morphology1.56056481
28MP0009697_abnormal_copulation1.48584035
29MP0000350_abnormal_cell_proliferation1.48136180
30MP0002084_abnormal_developmental_patter1.45575083
31MP0004859_abnormal_synaptic_plasticity1.45384212
32MP0001730_embryonic_growth_arrest1.44120385
33MP0009250_abnormal_appendicular_skeleto1.42788740
34MP0001293_anophthalmia1.42470010
35MP0001672_abnormal_embryogenesis/_devel1.42123161
36MP0005380_embryogenesis_phenotype1.42123161
37MP0001697_abnormal_embryo_size1.41611899
38MP0005367_renal/urinary_system_phenotyp1.41204200
39MP0000516_abnormal_urinary_system1.41204200
40MP0003718_maternal_effect1.40803356
41MP0008995_early_reproductive_senescence1.40563905
42MP0005499_abnormal_olfactory_system1.38924939
43MP0005394_taste/olfaction_phenotype1.38924939
44MP0005248_abnormal_Harderian_gland1.37245956
45MP0003786_premature_aging1.34845258
46MP0004197_abnormal_fetal_growth/weight/1.34799732
47MP0003890_abnormal_embryonic-extraembry1.31983949
48MP0000015_abnormal_ear_pigmentation1.29806994
49MP0009053_abnormal_anal_canal1.29703355
50MP0003693_abnormal_embryo_hatching1.29560979
51MP0003861_abnormal_nervous_system1.28829826
52MP0001984_abnormal_olfaction1.28239401
53MP0002638_abnormal_pupillary_reflex1.26803431
54MP0002116_abnormal_craniofacial_bone1.26501040
55MP0003115_abnormal_respiratory_system1.24780403
56MP0002111_abnormal_tail_morphology1.24602629
57MP0005174_abnormal_tail_pigmentation1.23924239
58MP0000534_abnormal_ureter_morphology1.23913153
59MP0003136_yellow_coat_color1.23633906
60MP0003935_abnormal_craniofacial_develop1.21804029
61MP0003984_embryonic_growth_retardation1.21034153
62MP0000537_abnormal_urethra_morphology1.20104174
63MP0002163_abnormal_gland_morphology1.18559397
64MP0002088_abnormal_embryonic_growth/wei1.18148981
65MP0002184_abnormal_innervation1.17914956
66MP0009672_abnormal_birth_weight1.17273818
67MP0005171_absent_coat_pigmentation1.17226163
68MP0003880_abnormal_central_pattern1.16990704
69MP0002095_abnormal_skin_pigmentation1.16527623
70MP0002751_abnormal_autonomic_nervous1.14937323
71MP0003755_abnormal_palate_morphology1.14923778
72MP0005409_darkened_coat_color1.14550090
73MP0003123_paternal_imprinting1.12817354
74MP0002234_abnormal_pharynx_morphology1.12289802
75MP0001286_abnormal_eye_development1.11931231
76MP0004808_abnormal_hematopoietic_stem1.11750935
77MP0003937_abnormal_limbs/digits/tail_de1.11389037
78MP0002396_abnormal_hematopoietic_system1.11028152
79MP0004133_heterotaxia1.09573993
80MP0005646_abnormal_pituitary_gland1.09030619
81MP0002080_prenatal_lethality1.08235492
82MP0000428_abnormal_craniofacial_morphol1.07557126
83MP0002210_abnormal_sex_determination1.04521327
84MP0001145_abnormal_male_reproductive1.04138895
85MP0002092_abnormal_eye_morphology1.03711196
86MP0002081_perinatal_lethality1.02851048
87MP0004885_abnormal_endolymph1.02141289
88MP0002557_abnormal_social/conspecific_i1.00611899
89MP0002177_abnormal_outer_ear1.00265867
90MP0000026_abnormal_inner_ear1.00094226
91MP0002697_abnormal_eye_size0.99905537
92MP0001929_abnormal_gametogenesis0.99785424
93MP0003221_abnormal_cardiomyocyte_apopto0.99350184
94MP0002249_abnormal_larynx_morphology0.99026359
95MP0002063_abnormal_learning/memory/cond0.99010908
96MP0001177_atelectasis0.97013477
97MP0001346_abnormal_lacrimal_gland0.96372616
98MP0000653_abnormal_sex_gland0.96039845
99MP0002152_abnormal_brain_morphology0.95859724
100MP0005187_abnormal_penis_morphology0.95526758
101MP0010307_abnormal_tumor_latency0.95466071
102MP0001485_abnormal_pinna_reflex0.95212088
103MP0002932_abnormal_joint_morphology0.95085629
104MP0008932_abnormal_embryonic_tissue0.93428330
105MP0001486_abnormal_startle_reflex0.93415814
106MP0002233_abnormal_nose_morphology0.92941283
107MP0003635_abnormal_synaptic_transmissio0.91931297
108MP0002160_abnormal_reproductive_system0.91826259
109MP0000313_abnormal_cell_death0.89312937
110MP0000647_abnormal_sebaceous_gland0.88938259
111MP0004147_increased_porphyrin_level0.88400354
112MP0006072_abnormal_retinal_apoptosis0.87980540
113MP0000372_irregular_coat_pigmentation0.87590260
114MP0000955_abnormal_spinal_cord0.86998164
115MP0004811_abnormal_neuron_physiology0.86325288
116MP0002109_abnormal_limb_morphology0.86208282
117MP0001119_abnormal_female_reproductive0.86141798
118MP0002882_abnormal_neuron_morphology0.85822477
119MP0001529_abnormal_vocalization0.85315002
120MP0005253_abnormal_eye_physiology0.85221949
121MP0006035_abnormal_mitochondrial_morpho0.84959901
122MP0003119_abnormal_digestive_system0.84738620
123MP0002735_abnormal_chemical_nociception0.84507048
124MP0002114_abnormal_axial_skeleton0.82952806
125MP0002067_abnormal_sensory_capabilities0.82728710
126MP0001270_distended_abdomen0.82625221
127MP0003941_abnormal_skin_development0.82375702
128MP0004957_abnormal_blastocyst_morpholog0.82370323
129MP0002736_abnormal_nociception_after0.82104759
130MP0005391_vision/eye_phenotype0.81825990
131MP0002085_abnormal_embryonic_tissue0.81031900
132MP0002086_abnormal_extraembryonic_tissu0.80271848
133MP0003315_abnormal_perineum_morphology0.79023383
134MP0005645_abnormal_hypothalamus_physiol0.78965555
135MP0002572_abnormal_emotion/affect_behav0.78699273
136MP0005551_abnormal_eye_electrophysiolog0.77714182
137MP0002752_abnormal_somatic_nervous0.76312169
138MP0009703_decreased_birth_body0.76058067
139MP0003698_abnormal_male_reproductive0.75442527
140MP0000432_abnormal_head_morphology0.70315938
141MP0000579_abnormal_nail_morphology0.69777317
142MP0002282_abnormal_trachea_morphology0.67883007
143MP0006276_abnormal_autonomic_nervous0.66134616

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.78861354
2Short 4th metacarpal (HP:0010044)3.78861354
3Volvulus (HP:0002580)3.37549522
4Carpal bone hypoplasia (HP:0001498)3.14497416
5Abnormality of the preputium (HP:0100587)3.10598083
6Asymmetry of the thorax (HP:0001555)3.02142279
7Abnormality of the intervertebral disk (HP:0005108)2.96395646
8Cortical dysplasia (HP:0002539)2.92873157
9Abnormality of the labia minora (HP:0012880)2.92278756
10Abnormality of the fingertips (HP:0001211)2.72439335
11Patellar aplasia (HP:0006443)2.72149278
12Abnormal hair whorl (HP:0010721)2.64240995
13Abnormality of the 4th metacarpal (HP:0010012)2.61440794
14Hepatoblastoma (HP:0002884)2.57844040
15Abnormality of the duodenum (HP:0002246)2.57122588
16Sloping forehead (HP:0000340)2.53642507
17Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.52802078
18Aplasia/Hypoplasia of the patella (HP:0006498)2.51380917
19Triphalangeal thumb (HP:0001199)2.49508574
20Renal duplication (HP:0000075)2.47082873
21Increased nuchal translucency (HP:0010880)2.46428827
22Medulloblastoma (HP:0002885)2.43940553
23Myelodysplasia (HP:0002863)2.42336692
24Absent radius (HP:0003974)2.39739217
25Tented upper lip vermilion (HP:0010804)2.39720622
26Protruding tongue (HP:0010808)2.39308005
27Septo-optic dysplasia (HP:0100842)2.35387820
28Renal hypoplasia (HP:0000089)2.31557067
29Absent forearm bone (HP:0003953)2.30896856
30Aplasia involving forearm bones (HP:0009822)2.30896856
31Trigonocephaly (HP:0000243)2.26753638
32Reticulocytopenia (HP:0001896)2.25522504
33High anterior hairline (HP:0009890)2.24978860
34Nephroblastoma (Wilms tumor) (HP:0002667)2.24306572
35Abnormality of the ileum (HP:0001549)2.19460900
36Febrile seizures (HP:0002373)2.19246165
37Rhabdomyosarcoma (HP:0002859)2.19221786
38Meckel diverticulum (HP:0002245)2.17486836
39Morphological abnormality of the middle ear (HP:0008609)2.15650622
40Pendular nystagmus (HP:0012043)2.14841573
41Clubbing of toes (HP:0100760)2.13725479
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13345334
43Embryonal renal neoplasm (HP:0011794)2.12930580
44Midline defect of the nose (HP:0004122)2.11668757
45Slow-growing hair (HP:0002217)2.11155767
46Abnormality of hair growth rate (HP:0011363)2.11155767
47Acute lymphatic leukemia (HP:0006721)2.10710998
48Abnormal lung lobation (HP:0002101)2.10706974
49Elfin facies (HP:0004428)2.09431874
50Embryonal neoplasm (HP:0002898)2.08707456
51Papillary thyroid carcinoma (HP:0002895)2.07940005
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.06967345
53Supernumerary spleens (HP:0009799)2.06863158
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.06017602
55Abnormality of the incisor (HP:0000676)2.04841916
56Ependymoma (HP:0002888)2.04678773
57Obsessive-compulsive behavior (HP:0000722)2.03762179
58Syringomyelia (HP:0003396)2.03645360
59Spinal cord lesions (HP:0100561)2.03645360
60Abnormality of the metopic suture (HP:0005556)2.00698169
61Horseshoe kidney (HP:0000085)1.99925138
62Chromsome breakage (HP:0040012)1.99400823
63Gonadotropin excess (HP:0000837)1.99072598
64Shoulder girdle muscle weakness (HP:0003547)1.98177120
65Cutaneous finger syndactyly (HP:0010554)1.97862948
66Optic nerve coloboma (HP:0000588)1.97633121
67Cutaneous syndactyly (HP:0012725)1.96995461
68Colon cancer (HP:0003003)1.96806263
69Intestinal atresia (HP:0011100)1.96796787
70Heterochromia iridis (HP:0001100)1.96612868
71Abnormal number of incisors (HP:0011064)1.94983182
72Short philtrum (HP:0000322)1.90276518
73Hemivertebrae (HP:0002937)1.89723124
74Cutis marmorata (HP:0000965)1.89539967
75Neoplasm of the colon (HP:0100273)1.89477986
76Deep philtrum (HP:0002002)1.86276075
77Abnormality of the septum pellucidum (HP:0007375)1.86221363
78Glioma (HP:0009733)1.85871916
79Vertebral arch anomaly (HP:0008438)1.85117738
80Abnormality of the carotid arteries (HP:0005344)1.84351090
81Myelomeningocele (HP:0002475)1.84186015
82Long clavicles (HP:0000890)1.83032248
83Growth hormone deficiency (HP:0000824)1.82822605
84Abnormality of chromosome segregation (HP:0002916)1.81635662
85Anophthalmia (HP:0000528)1.81388207
86Lissencephaly (HP:0001339)1.80958665
87Duplicated collecting system (HP:0000081)1.80604617
88Ectopic kidney (HP:0000086)1.80536408
89Hypoplastic pelvis (HP:0008839)1.79747084
90Flat cornea (HP:0007720)1.79159988
91Broad alveolar ridges (HP:0000187)1.78959752
92True hermaphroditism (HP:0010459)1.78621255
93Spina bifida occulta (HP:0003298)1.78480572
94Preaxial hand polydactyly (HP:0001177)1.77879966
95Renovascular hypertension (HP:0100817)1.77259293
96Nephronophthisis (HP:0000090)1.76140459
97Thick eyebrow (HP:0000574)1.75540516
98Absent septum pellucidum (HP:0001331)1.73850795
99Pancreatic islet-cell hyperplasia (HP:0004510)1.71568844
100Long eyelashes (HP:0000527)1.70594797
101Fibular aplasia (HP:0002990)1.70208733
102Bilateral microphthalmos (HP:0007633)1.69973966
103Duodenal stenosis (HP:0100867)1.68089986
104Small intestinal stenosis (HP:0012848)1.68089986
105Smooth philtrum (HP:0000319)1.67983890
106Aqueductal stenosis (HP:0002410)1.66337569
107Hyperacusis (HP:0010780)1.66180472
108Esophageal atresia (HP:0002032)1.65888056
109Partial agenesis of the corpus callosum (HP:0001338)1.65149762
110Germ cell neoplasia (HP:0100728)1.65077738
111Abnormality of incisor morphology (HP:0011063)1.64410984
112Central scotoma (HP:0000603)1.64026464
113Pelvic girdle muscle weakness (HP:0003749)1.62902774
114Abnormality of the renal collecting system (HP:0004742)1.62782549
115Postaxial foot polydactyly (HP:0001830)1.62285974
116Hyperglycinemia (HP:0002154)1.61171227
117Arteriovenous malformation (HP:0100026)1.61073986
118Gastrointestinal atresia (HP:0002589)1.61062288
119Birth length less than 3rd percentile (HP:0003561)1.60704391
120Bifid tongue (HP:0010297)1.60320227
121Scotoma (HP:0000575)1.60137422
122Duplication of thumb phalanx (HP:0009942)1.59899525
123Pointed chin (HP:0000307)1.59880629
124Dandy-Walker malformation (HP:0001305)1.59779522
125Astigmatism (HP:0000483)1.58987432
126Oligodactyly (hands) (HP:0001180)1.58769737
127Neoplasm of striated muscle (HP:0009728)1.58738805
128Ovarian neoplasm (HP:0100615)1.58409133
129Small hand (HP:0200055)1.58385986
130Short thumb (HP:0009778)1.57772786
131Abnormality of chromosome stability (HP:0003220)1.57718825
132Abnormal number of erythroid precursors (HP:0012131)1.56923581
133Cafe-au-lait spot (HP:0000957)1.55875927
134Stenosis of the external auditory canal (HP:0000402)1.55295690
135Anencephaly (HP:0002323)1.54762178
136Tracheomalacia (HP:0002779)1.54118973
137Absent thumb (HP:0009777)1.53938325
138Abnormality of the astrocytes (HP:0100707)1.53926597
139Astrocytoma (HP:0009592)1.53926597
140Epileptic encephalopathy (HP:0200134)1.53488199
141Holoprosencephaly (HP:0001360)1.53342706
142Anal atresia (HP:0002023)1.53250909
143Pancreatic fibrosis (HP:0100732)1.52090174
144Abnormality of cochlea (HP:0000375)1.51250964
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.51157273
146Abnormality of the nasolacrimal system (HP:0000614)1.50510981
147Abnormality of the diencephalon (HP:0010662)1.49552045
148Tracheoesophageal fistula (HP:0002575)1.49532738
149Cellular immunodeficiency (HP:0005374)1.49326682
150Progressive sensorineural hearing impairment (HP:0000408)1.48974268
151Neoplasm of the adrenal cortex (HP:0100641)1.48818073
152Oral leukoplakia (HP:0002745)1.48422959
153Irregular epiphyses (HP:0010582)1.47761327
154Pancreatic cysts (HP:0001737)1.47475239
155Chorioretinal atrophy (HP:0000533)1.47392518
156Abnormality of the parietal bone (HP:0002696)1.47350407
157Congenital diaphragmatic hernia (HP:0000776)1.46499714
158Oligodactyly (HP:0012165)1.46461189
159Sacral dimple (HP:0000960)1.46100827
160Diastasis recti (HP:0001540)1.45913773
161Abnormality of the columella (HP:0009929)1.45693460
162Supernumerary ribs (HP:0005815)1.45214062
163Microtia (HP:0008551)1.44547859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK13.40554494
2MKNK13.35294569
3ERBB33.25930680
4MKNK23.09444653
5TTK3.06535528
6TNIK2.83105429
7MARK12.78327805
8NEK12.76510840
9CASK2.66609505
10STK162.60334275
11SIK32.50599208
12CCNB12.47027468
13CDC72.37499099
14MAPK132.22496792
15PBK2.06000987
16YES12.00343413
17MAP2K71.98319820
18TRIM281.94503898
19LATS11.83187745
20NTRK21.76067478
21TAF11.73438736
22VRK21.72960692
23EIF2AK31.55590595
24PLK31.55440378
25MUSK1.54563600
26BRD41.53794801
27PRPF4B1.52926762
28DYRK21.52371697
29BUB11.46552951
30SGK21.39369116
31PLK41.37552303
32ATR1.37490863
33CLK11.28013218
34KSR11.24740483
35MAP4K21.23305413
36RPS6KA41.21166391
37VRK11.21073865
38TAOK21.20552029
39PASK1.17713819
40PNCK1.17244201
41SIK21.16733873
42DYRK1A1.15024280
43TSSK61.12154463
44BMPR1B1.12075910
45PLK21.05539979
46EPHA30.98408136
47PLK10.98145923
48EPHB20.96069633
49BRSK10.95117308
50MAP3K40.94283649
51UHMK10.93576091
52CDK80.93032603
53NEK20.91594398
54ZAK0.91401037
55DYRK30.90112144
56EIF2AK20.88159861
57STK40.88045319
58STK30.86804909
59TXK0.86480276
60INSRR0.85018294
61CSNK1G10.83826699
62FGFR20.80535054
63MAP3K100.77672664
64CDK10.77080665
65SGK2230.76194672
66SGK4940.76194672
67BCR0.76101669
68RPS6KA20.75589341
69CHEK10.73576766
70NTRK30.72545147
71FGFR10.71929423
72MINK10.70864128
73AKT30.69895663
74* AURKB0.69557367
75BRSK20.68744232
76EPHA40.68690858
77SGK30.67560466
78CDK30.67419433
79ATM0.65398055
80ERBB20.64014278
81MST40.63839338
82CSNK1G30.61573961
83WNK30.61405193
84MAPK90.60901622
85DAPK10.60541660
86CDK190.60138486
87BLK0.60105587
88CDK70.59981741
89TLK10.59914655
90* CDK20.59080837
91RPS6KB10.58039719
92CDK60.57895389
93IRAK20.56778686
94STK38L0.56197634
95NUAK10.55162000
96AKT20.55151818
97IRAK10.54830751
98ILK0.53429298
99CHEK20.53221600
100CSNK1A1L0.52940706
101TGFBR10.51868028
102CAMK40.50599204
103NLK0.50525563
104CSNK1G20.49551453
105AURKA0.46165000
106ACVR1B0.45208019
107CAMK1G0.45090400
108FGFR30.44182378
109* MAPK80.44182145
110NME10.43421633
111CDK90.42983819
112* GSK3B0.42907558
113PDGFRA0.42378961
114RPS6KC10.42230780
115RPS6KL10.42230780
116CSNK2A10.41970179
117LIMK10.41306760
118DYRK1B0.41005514
119MAPK140.40973310
120CHUK0.40343018
121MELK0.40300710
122CSNK2A20.39872826
123KIT0.39692729
124CSNK1E0.39249512
125PRKDC0.38400629
126AKT10.37953295
127EIF2AK10.37497138
128CDK40.37051260
129WEE10.36514861
130RPS6KB20.35612541
131ROCK10.35396592
132MAP3K120.35309817
133PKN10.35267063
134RPS6KA50.33854072
135ALK0.33727089
136GRK10.32674322
137BCKDK0.28268359
138ERBB40.26693812
139CDK180.22515168
140PIM10.22249231
141PDK20.21124614

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.78860139
2Cell cycle_Homo sapiens_hsa041102.77612150
3* Spliceosome_Homo sapiens_hsa030402.74626047
4Base excision repair_Homo sapiens_hsa034102.62137480
5Mismatch repair_Homo sapiens_hsa034302.57277414
6Ribosome_Homo sapiens_hsa030102.39576733
7mRNA surveillance pathway_Homo sapiens_hsa030152.27525553
8Proteasome_Homo sapiens_hsa030502.11737273
9Homologous recombination_Homo sapiens_hsa034402.06749236
10Basal cell carcinoma_Homo sapiens_hsa052172.00503599
11One carbon pool by folate_Homo sapiens_hsa006701.87718003
12Non-homologous end-joining_Homo sapiens_hsa034501.80959562
13Protein export_Homo sapiens_hsa030601.73978877
14Fanconi anemia pathway_Homo sapiens_hsa034601.72607588
15RNA transport_Homo sapiens_hsa030131.69095589
16Nucleotide excision repair_Homo sapiens_hsa034201.66301407
17Nicotine addiction_Homo sapiens_hsa050331.65118080
18Colorectal cancer_Homo sapiens_hsa052101.65112289
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58451760
20Phototransduction_Homo sapiens_hsa047441.51120732
21Endometrial cancer_Homo sapiens_hsa052131.46446271
22Axon guidance_Homo sapiens_hsa043601.44036608
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.43678242
24Propanoate metabolism_Homo sapiens_hsa006401.43607889
25RNA degradation_Homo sapiens_hsa030181.41005510
26Notch signaling pathway_Homo sapiens_hsa043301.40410228
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.37536074
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.32086120
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31058941
30Hedgehog signaling pathway_Homo sapiens_hsa043401.29722273
31Steroid biosynthesis_Homo sapiens_hsa001001.28668454
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28417870
33Selenocompound metabolism_Homo sapiens_hsa004501.25339987
34MicroRNAs in cancer_Homo sapiens_hsa052061.24002279
35Basal transcription factors_Homo sapiens_hsa030221.20565031
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17420274
37Oocyte meiosis_Homo sapiens_hsa041141.16604242
38Wnt signaling pathway_Homo sapiens_hsa043101.16351219
39Circadian entrainment_Homo sapiens_hsa047131.15589442
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14736993
41HTLV-I infection_Homo sapiens_hsa051661.12638100
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12236216
43Alcoholism_Homo sapiens_hsa050341.12132763
44Glutamatergic synapse_Homo sapiens_hsa047241.11916040
45RNA polymerase_Homo sapiens_hsa030201.06878220
46Parkinsons disease_Homo sapiens_hsa050121.05407730
47Pyruvate metabolism_Homo sapiens_hsa006201.05168747
48Morphine addiction_Homo sapiens_hsa050321.04655455
49Viral myocarditis_Homo sapiens_hsa054161.03336471
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02497829
51Lysine degradation_Homo sapiens_hsa003101.01982732
52Primary immunodeficiency_Homo sapiens_hsa053401.01905728
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01151569
54Hippo signaling pathway_Homo sapiens_hsa043901.01018170
55Herpes simplex infection_Homo sapiens_hsa051680.98456293
56Huntingtons disease_Homo sapiens_hsa050160.98372062
57Olfactory transduction_Homo sapiens_hsa047400.98338850
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97975439
59Dopaminergic synapse_Homo sapiens_hsa047280.96211443
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95408662
61GABAergic synapse_Homo sapiens_hsa047270.92843577
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91459143
63Biosynthesis of amino acids_Homo sapiens_hsa012300.90019327
64Chronic myeloid leukemia_Homo sapiens_hsa052200.89536627
65Cholinergic synapse_Homo sapiens_hsa047250.86725387
66N-Glycan biosynthesis_Homo sapiens_hsa005100.86719492
67Epstein-Barr virus infection_Homo sapiens_hsa051690.85384633
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84988672
69Systemic lupus erythematosus_Homo sapiens_hsa053220.82289674
70Circadian rhythm_Homo sapiens_hsa047100.81090607
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80156439
72Oxidative phosphorylation_Homo sapiens_hsa001900.79466357
73Pyrimidine metabolism_Homo sapiens_hsa002400.78113555
74p53 signaling pathway_Homo sapiens_hsa041150.77268528
75TGF-beta signaling pathway_Homo sapiens_hsa043500.76720457
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76422500
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75689670
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74426148
79Non-small cell lung cancer_Homo sapiens_hsa052230.74413888
80Hepatitis B_Homo sapiens_hsa051610.72634316
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72337816
82Cocaine addiction_Homo sapiens_hsa050300.70260172
83Pathways in cancer_Homo sapiens_hsa052000.69931045
84Viral carcinogenesis_Homo sapiens_hsa052030.69432786
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69366216
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67726353
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.67687773
88Long-term depression_Homo sapiens_hsa047300.66366396
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65894998
90Long-term potentiation_Homo sapiens_hsa047200.65350886
91Glioma_Homo sapiens_hsa052140.64985064
92Fatty acid elongation_Homo sapiens_hsa000620.64548833
93T cell receptor signaling pathway_Homo sapiens_hsa046600.64179140
94Small cell lung cancer_Homo sapiens_hsa052220.62901177
95Purine metabolism_Homo sapiens_hsa002300.62710496
96Carbon metabolism_Homo sapiens_hsa012000.62231860
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61649035
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60991678
99Melanoma_Homo sapiens_hsa052180.60989792
100Melanogenesis_Homo sapiens_hsa049160.59827260
101Amphetamine addiction_Homo sapiens_hsa050310.59794289
102ErbB signaling pathway_Homo sapiens_hsa040120.58754145
103Serotonergic synapse_Homo sapiens_hsa047260.58251372
104Pancreatic cancer_Homo sapiens_hsa052120.57708637
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57538914
106Prostate cancer_Homo sapiens_hsa052150.57205539
107FoxO signaling pathway_Homo sapiens_hsa040680.56045928
108Thyroid cancer_Homo sapiens_hsa052160.55594799
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54922028
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54584027
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53608331
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.51590989
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49356148
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48729055
115Measles_Homo sapiens_hsa051620.48722214
116Gap junction_Homo sapiens_hsa045400.48338666
117mTOR signaling pathway_Homo sapiens_hsa041500.48084922
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47910291
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44198056
120Type I diabetes mellitus_Homo sapiens_hsa049400.43523643
121Butanoate metabolism_Homo sapiens_hsa006500.42731251
122Adherens junction_Homo sapiens_hsa045200.42018398
123MAPK signaling pathway_Homo sapiens_hsa040100.41465774
124Taste transduction_Homo sapiens_hsa047420.41224921
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.40190870
126Oxytocin signaling pathway_Homo sapiens_hsa049210.39844873
127Alzheimers disease_Homo sapiens_hsa050100.38996975
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38438777
129Influenza A_Homo sapiens_hsa051640.37553788
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35096832
131Metabolic pathways_Homo sapiens_hsa011000.29888419
132Glutathione metabolism_Homo sapiens_hsa004800.27224443
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.24055083
134Fatty acid metabolism_Homo sapiens_hsa012120.23491787
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22864950
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19621178
137Vitamin B6 metabolism_Homo sapiens_hsa007500.17617970
138Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15193768
139Folate biosynthesis_Homo sapiens_hsa007900.14355608
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12768888
141Vitamin digestion and absorption_Homo sapiens_hsa049770.12244999
142Regulation of autophagy_Homo sapiens_hsa041400.11706011
143Tight junction_Homo sapiens_hsa045300.10978453
144Ether lipid metabolism_Homo sapiens_hsa005650.07641397
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06473431
146Nitrogen metabolism_Homo sapiens_hsa009100.05764184

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