RBMX2P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.56406656
2pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.25401045
3cytidine deamination (GO:0009972)4.71455447
4cytidine metabolic process (GO:0046087)4.71455447
5cytidine catabolic process (GO:0006216)4.71455447
6pyrimidine nucleotide catabolic process (GO:0006244)4.65533289
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.47565551
8pyrimidine ribonucleoside catabolic process (GO:0046133)4.22969026
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.21012755
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.17218622
11T cell migration (GO:0072678)3.93052453
12ATP synthesis coupled proton transport (GO:0015986)3.88651387
13energy coupled proton transport, down electrochemical gradient (GO:0015985)3.88651387
14signal peptide processing (GO:0006465)3.84604395
15maturation of 5.8S rRNA (GO:0000460)3.77664338
16electron transport chain (GO:0022900)3.69175062
17negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.68152020
18respiratory electron transport chain (GO:0022904)3.60322745
19protein complex biogenesis (GO:0070271)3.54705414
20cellular response to zinc ion (GO:0071294)3.54282254
21behavioral response to nicotine (GO:0035095)3.53919954
22negative regulation of mast cell activation (GO:0033004)3.53870102
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.52042664
24positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.50851063
25base-excision repair, AP site formation (GO:0006285)3.44102030
26negative regulation of T cell differentiation in thymus (GO:0033085)3.44055487
27regulation of activation of Janus kinase activity (GO:0010533)3.38233544
28activated T cell proliferation (GO:0050798)3.33579371
29response to interferon-beta (GO:0035456)3.31021944
30pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.30948757
31negative regulation of telomere maintenance (GO:0032205)3.30605990
32negative regulation of T cell receptor signaling pathway (GO:0050860)3.29379962
33positive regulation of defense response to virus by host (GO:0002230)3.29125406
34regulation of T cell receptor signaling pathway (GO:0050856)3.23816169
35regulation of cytokine production involved in inflammatory response (GO:1900015)3.19014355
36negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.18645417
37ubiquinone biosynthetic process (GO:0006744)3.14896975
38heme transport (GO:0015886)3.12836141
39positive T cell selection (GO:0043368)3.12309214
40cytochrome complex assembly (GO:0017004)3.10296891
41mitochondrial respiratory chain complex assembly (GO:0033108)3.06802990
42pseudouridine synthesis (GO:0001522)3.05556881
43iron-sulfur cluster assembly (GO:0016226)3.04165847
44metallo-sulfur cluster assembly (GO:0031163)3.04165847
45dendritic spine morphogenesis (GO:0060997)2.97720538
46positive regulation of calcium-mediated signaling (GO:0050850)2.97698717
47positive regulation of histone H3-K4 methylation (GO:0051571)2.97401599
48neuron fate determination (GO:0048664)2.87973542
49macrophage chemotaxis (GO:0048246)2.85863801
50protein-cofactor linkage (GO:0018065)2.84369191
51positive regulation of uterine smooth muscle contraction (GO:0070474)2.83374559
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83121314
53mitochondrial respiratory chain complex I assembly (GO:0032981)2.83121314
54NADH dehydrogenase complex assembly (GO:0010257)2.83121314
55regulation of B cell receptor signaling pathway (GO:0050855)2.82835990
56cellular response to interferon-beta (GO:0035458)2.82691163
57ubiquinone metabolic process (GO:0006743)2.79599682
58quinone biosynthetic process (GO:1901663)2.79176523
59adult feeding behavior (GO:0008343)2.77432832
60positive thymic T cell selection (GO:0045059)2.77155267
61axonemal dynein complex assembly (GO:0070286)2.75758538
62regulation of chronic inflammatory response (GO:0002676)2.74714427
63indolalkylamine metabolic process (GO:0006586)2.70949437
64regulation of synapse structural plasticity (GO:0051823)2.69604987
65regulation of endothelial cell differentiation (GO:0045601)2.69090177
66regulation of appetite (GO:0032098)2.68952353
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.66541876
68positive regulation of endothelial cell differentiation (GO:0045603)2.65167886
69negative regulation by host of viral transcription (GO:0043922)2.64618930
70water-soluble vitamin biosynthetic process (GO:0042364)2.63728161
71respiratory chain complex IV assembly (GO:0008535)2.61611697
72cilium movement (GO:0003341)2.61508661
73regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.61135236
74deoxyribonucleotide catabolic process (GO:0009264)2.60642106
75actin nucleation (GO:0045010)2.59775941
76negative regulation of appetite (GO:0032099)2.58850200
77negative regulation of response to food (GO:0032096)2.58850200
78negative T cell selection (GO:0043383)2.58730872
79regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.57868753
80pyrimidine nucleoside catabolic process (GO:0046135)2.56571193
81axon ensheathment in central nervous system (GO:0032291)2.55575306
82central nervous system myelination (GO:0022010)2.55575306
83histone mRNA metabolic process (GO:0008334)2.55413016
84regulation of mitochondrial translation (GO:0070129)2.54410086
85isoprenoid biosynthetic process (GO:0008299)2.53653062
86deoxyribose phosphate catabolic process (GO:0046386)2.53373709
87protein heterotetramerization (GO:0051290)2.51080910
88tryptophan catabolic process (GO:0006569)2.50615953
89indole-containing compound catabolic process (GO:0042436)2.50615953
90indolalkylamine catabolic process (GO:0046218)2.50615953
91proton transport (GO:0015992)2.50570201
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.50258899
93positive regulation of granulocyte differentiation (GO:0030854)2.49880388
94hydrogen ion transmembrane transport (GO:1902600)2.49545282
95hydrogen transport (GO:0006818)2.48342132
96regulation of rhodopsin mediated signaling pathway (GO:0022400)2.46512154
97cellular response to interleukin-15 (GO:0071350)2.45515571
98regulation of calcium-mediated signaling (GO:0050848)2.44917712
99positive regulation of steroid hormone secretion (GO:2000833)2.44628822
100mannosylation (GO:0097502)2.42511893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.43069092
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.92310600
3IGF1R_20145208_ChIP-Seq_DFB_Human3.88580965
4EZH2_22144423_ChIP-Seq_EOC_Human3.77416184
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.95423744
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.90427240
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68062156
8ZNF274_21170338_ChIP-Seq_K562_Hela2.53369603
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.34763115
10VDR_22108803_ChIP-Seq_LS180_Human2.10588656
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99064225
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94519674
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93386486
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87209812
15NOTCH1_21737748_ChIP-Seq_TLL_Human1.85986345
16BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81819679
17ER_23166858_ChIP-Seq_MCF-7_Human1.78814377
18FUS_26573619_Chip-Seq_HEK293_Human1.77961431
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75936746
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75799371
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.74836657
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.69017879
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68929989
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.68401144
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68394780
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63189899
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55457764
28P300_19829295_ChIP-Seq_ESCs_Human1.55151960
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55127101
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.53126151
31HTT_18923047_ChIP-ChIP_STHdh_Human1.52954363
32AR_21572438_ChIP-Seq_LNCaP_Human1.52162493
33RNF2_27304074_Chip-Seq_NSC_Mouse1.51952601
34VDR_23849224_ChIP-Seq_CD4+_Human1.47587141
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46870381
36AR_20517297_ChIP-Seq_VCAP_Human1.42871113
37MYC_18940864_ChIP-ChIP_HL60_Human1.41659152
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39433656
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39433656
40PRDM14_20953172_ChIP-Seq_ESCs_Human1.35365009
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35357252
42CBP_20019798_ChIP-Seq_JUKART_Human1.35357252
43GATA3_26560356_Chip-Seq_TH2_Human1.35110168
44RUNX_20019798_ChIP-Seq_JUKART_Human1.34545864
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32269490
46MYB_26560356_Chip-Seq_TH2_Human1.32119450
47SOX2_19829295_ChIP-Seq_ESCs_Human1.29830663
48NANOG_19829295_ChIP-Seq_ESCs_Human1.29830663
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.29168692
50NCOR_22424771_ChIP-Seq_293T_Human1.27477277
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27438386
52TP53_22573176_ChIP-Seq_HFKS_Human1.26371948
53IRF1_19129219_ChIP-ChIP_H3396_Human1.25679211
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.24943143
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22951956
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22879501
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.22560654
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17721457
59GBX2_23144817_ChIP-Seq_PC3_Human1.17484517
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.15344035
61PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13862622
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13166231
63BCAT_22108803_ChIP-Seq_LS180_Human1.11315531
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10826660
65ERG_20517297_ChIP-Seq_VCAP_Human1.10173398
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.10034034
67GATA3_27048872_Chip-Seq_THYMUS_Human1.08872004
68MYC_19829295_ChIP-Seq_ESCs_Human1.08467565
69EWS_26573619_Chip-Seq_HEK293_Human1.08015840
70TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07907523
71TCF4_22108803_ChIP-Seq_LS180_Human1.07557616
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07076774
73TAF2_19829295_ChIP-Seq_ESCs_Human1.06594671
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06341720
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05736363
76NANOG_20526341_ChIP-Seq_ESCs_Human1.05615706
77REST_21632747_ChIP-Seq_MESCs_Mouse1.04946806
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04374031
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.03642065
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03642065
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03521206
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03354231
83TAF15_26573619_Chip-Seq_HEK293_Human1.02753117
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02295306
85ELK1_19687146_ChIP-ChIP_HELA_Human1.01682502
86ERA_21632823_ChIP-Seq_H3396_Human1.01652710
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01619538
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.01427142
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99542623
90P53_21459846_ChIP-Seq_SAOS-2_Human0.99193797
91SRF_21415370_ChIP-Seq_HL-1_Mouse0.98967049
92SMAD3_21741376_ChIP-Seq_EPCs_Human0.98394912
93RUNX2_22187159_ChIP-Seq_PCA_Human0.97686109
94EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97148485
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96746898
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96406026
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95722548
98JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95506512
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94126418
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93454948

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.38436821
2MP0005671_abnormal_response_to4.37054296
3MP0003880_abnormal_central_pattern3.44923039
4MP0004147_increased_porphyrin_level3.40494809
5MP0002138_abnormal_hepatobiliary_system2.86526561
6MP0005387_immune_system_phenotype2.28002332
7MP0001790_abnormal_immune_system2.28002332
8MP0009785_altered_susceptibility_to2.13766322
9MP0000372_irregular_coat_pigmentation2.12698217
10MP0001968_abnormal_touch/_nociception2.10671624
11MP0002837_dystrophic_cardiac_calcinosis2.00406141
12MP0000685_abnormal_immune_system1.99993963
13MP0006276_abnormal_autonomic_nervous1.96134012
14MP0005084_abnormal_gallbladder_morpholo1.92386381
15MP0006072_abnormal_retinal_apoptosis1.86343343
16MP0003763_abnormal_thymus_physiology1.83878018
17MP0008872_abnormal_physiological_respon1.75139926
18MP0008057_abnormal_DNA_replication1.74540919
19MP0000569_abnormal_digit_pigmentation1.70498829
20MP0009046_muscle_twitch1.64397990
21MP0001835_abnormal_antigen_presentation1.60890148
22MP0003136_yellow_coat_color1.58700437
23MP0003646_muscle_fatigue1.54445198
24MP0001905_abnormal_dopamine_level1.52297855
25MP0002733_abnormal_thermal_nociception1.52025192
26MP0003638_abnormal_response/metabolism_1.50091896
27MP0002148_abnormal_hypersensitivity_rea1.44458009
28MP0003866_abnormal_defecation1.42218859
29MP0001800_abnormal_humoral_immune1.39779263
30MP0002277_abnormal_respiratory_mucosa1.33139405
31MP0003045_fibrosis1.29596142
32MP0001873_stomach_inflammation1.29436567
33MP0009745_abnormal_behavioral_response1.27720298
34MP0001970_abnormal_pain_threshold1.27674248
35MP0002095_abnormal_skin_pigmentation1.27031985
36MP0005025_abnormal_response_to1.25935259
37MP0005075_abnormal_melanosome_morpholog1.25857299
38MP0008058_abnormal_DNA_repair1.23827314
39MP0005645_abnormal_hypothalamus_physiol1.23669727
40MP0005167_abnormal_blood-brain_barrier1.23443792
41MP0005551_abnormal_eye_electrophysiolog1.21697566
42MP0004145_abnormal_muscle_electrophysio1.19872455
43MP0004043_abnormal_pH_regulation1.18358776
44MP0001501_abnormal_sleep_pattern1.17901550
45MP0002938_white_spotting1.17404581
46MP0002272_abnormal_nervous_system1.17227509
47MP0003195_calcinosis1.14818569
48MP0002723_abnormal_immune_serum1.14755009
49MP0002420_abnormal_adaptive_immunity1.14632160
50MP0001879_abnormal_lymphatic_vessel1.14485771
51MP0002933_joint_inflammation1.14275840
52MP0010386_abnormal_urinary_bladder1.13868899
53MP0001984_abnormal_olfaction1.11341628
54MP0009333_abnormal_splenocyte_physiolog1.09962920
55MP0003724_increased_susceptibility_to1.09804040
56MP0001819_abnormal_immune_cell1.08473738
57MP0002405_respiratory_system_inflammati1.05832618
58MP0002736_abnormal_nociception_after1.04125004
59MP0006082_CNS_inflammation1.03915185
60MP0008875_abnormal_xenobiotic_pharmacok1.03335214
61MP0005174_abnormal_tail_pigmentation1.03272582
62MP0005646_abnormal_pituitary_gland1.02552182
63MP0004142_abnormal_muscle_tone1.00998687
64MP0003283_abnormal_digestive_organ1.00397061
65MP0005253_abnormal_eye_physiology0.99719915
66MP0003011_delayed_dark_adaptation0.96725796
67MP0001765_abnormal_ion_homeostasis0.96559778
68MP0004885_abnormal_endolymph0.93386389
69MP0001919_abnormal_reproductive_system0.92401331
70MP0002067_abnormal_sensory_capabilities0.91619133
71MP0003329_amyloid_beta_deposits0.90900401
72MP0002572_abnormal_emotion/affect_behav0.90764878
73MP0006036_abnormal_mitochondrial_physio0.89961892
74MP0003806_abnormal_nucleotide_metabolis0.89949100
75MP0003950_abnormal_plasma_membrane0.89520341
76MP0002452_abnormal_antigen_presenting0.89418926
77MP0004134_abnormal_chest_morphology0.88088711
78MP0008569_lethality_at_weaning0.86215309
79MP0008877_abnormal_DNA_methylation0.86048766
80MP0005410_abnormal_fertilization0.84999991
81MP0008775_abnormal_heart_ventricle0.84672197
82MP0004858_abnormal_nervous_system0.84019023
83MP0009379_abnormal_foot_pigmentation0.83122255
84MP0002557_abnormal_social/conspecific_i0.82390475
85MP0002166_altered_tumor_susceptibility0.82181840
86MP0000716_abnormal_immune_system0.80822924
87MP0002102_abnormal_ear_morphology0.80702590
88MP0005636_abnormal_mineral_homeostasis0.80041413
89MP0001485_abnormal_pinna_reflex0.79622382
90MP0002734_abnormal_mechanical_nocicepti0.79580753
91MP0002184_abnormal_innervation0.79446605
92MP0005000_abnormal_immune_tolerance0.79311834
93MP0002064_seizures0.78424461
94MP0003137_abnormal_impulse_conducting0.78400399
95MP0001529_abnormal_vocalization0.76869381
96MP0000604_amyloidosis0.75708551
97MP0000538_abnormal_urinary_bladder0.74345163
98MP0002638_abnormal_pupillary_reflex0.73983404
99MP0004742_abnormal_vestibular_system0.73448299
100MP0002398_abnormal_bone_marrow0.73230476

Predicted human phenotypes

RankGene SetZ-score
1Congenital, generalized hypertrichosis (HP:0004540)4.24058532
2Elevated erythrocyte sedimentation rate (HP:0003565)3.92267558
3Pancreatic cysts (HP:0001737)3.90012986
4Congenital stationary night blindness (HP:0007642)3.84837084
5True hermaphroditism (HP:0010459)3.80336131
6Abnormal ciliary motility (HP:0012262)3.75032100
7Pancreatic fibrosis (HP:0100732)3.66987416
8Severe combined immunodeficiency (HP:0004430)3.62286792
9Molar tooth sign on MRI (HP:0002419)3.53630609
10Abnormality of midbrain morphology (HP:0002418)3.53630609
11T lymphocytopenia (HP:0005403)3.45356201
12Acute necrotizing encephalopathy (HP:0006965)3.44630055
13Hemiparesis (HP:0001269)3.44144071
14Increased CSF lactate (HP:0002490)3.35481076
15Mitochondrial inheritance (HP:0001427)3.26852223
16Abnormality of T cell number (HP:0011839)3.24828650
17Hypoproteinemia (HP:0003075)3.13066330
18Hepatocellular necrosis (HP:0001404)3.05749503
19Thyroiditis (HP:0100646)3.02759618
20Abnormal biliary tract physiology (HP:0012439)2.91100445
21Bile duct proliferation (HP:0001408)2.91100445
22Stomatitis (HP:0010280)2.87352095
23Abnormal mitochondria in muscle tissue (HP:0008316)2.85958089
24Abnormal rod and cone electroretinograms (HP:0008323)2.82423674
25Nephronophthisis (HP:0000090)2.78192021
26Combined immunodeficiency (HP:0005387)2.77400922
27Prostate neoplasm (HP:0100787)2.76346074
28Progressive macrocephaly (HP:0004481)2.72857463
29Hepatic necrosis (HP:0002605)2.71958040
30Vacuolated lymphocytes (HP:0001922)2.71343218
31Acute encephalopathy (HP:0006846)2.67543861
32Aplastic anemia (HP:0001915)2.66875739
33Renal Fanconi syndrome (HP:0001994)2.60896510
34IgG deficiency (HP:0004315)2.55905652
353-Methylglutaconic aciduria (HP:0003535)2.55696617
36Increased hepatocellular lipid droplets (HP:0006565)2.54510064
37Abnormal respiratory motile cilium physiology (HP:0012261)2.51203716
38Abnormality of eosinophils (HP:0001879)2.50015631
39Constricted visual fields (HP:0001133)2.47803906
40Generalized aminoaciduria (HP:0002909)2.47045962
41Abnormality of T cells (HP:0002843)2.40483289
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40080494
43Lipid accumulation in hepatocytes (HP:0006561)2.37482607
44Paralysis (HP:0003470)2.33898215
45Abnormality of B cell number (HP:0010975)2.31608157
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.25113150
47Absent/shortened dynein arms (HP:0200106)2.25113150
48Abnormality of the prostate (HP:0008775)2.25110100
49Cystic liver disease (HP:0006706)2.23985209
50Sclerocornea (HP:0000647)2.22914857
51Abnormality of the renal medulla (HP:0100957)2.21213898
52Abnormal drinking behavior (HP:0030082)2.18775453
53Polydipsia (HP:0001959)2.18775453
54Male pseudohermaphroditism (HP:0000037)2.18572503
55Chronic hepatic failure (HP:0100626)2.18335359
56Postaxial foot polydactyly (HP:0001830)2.15707666
57Optic disc pallor (HP:0000543)2.15117194
58Optic nerve coloboma (HP:0000588)2.09995424
59Hypoalbuminemia (HP:0003073)2.09272367
60Abnormal albumin level (HP:0012116)2.09272367
61Decreased circulating renin level (HP:0003351)2.07783908
62Abnormality of the renal collecting system (HP:0004742)2.04436048
63Bronchiectasis (HP:0002110)2.02499871
64Cerebral edema (HP:0002181)2.01801306
65Reticulocytopenia (HP:0001896)2.01217653
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00842238
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00842238
68Increased serum lactate (HP:0002151)1.99926799
69Abolished electroretinogram (ERG) (HP:0000550)1.98423121
70Abnormality of the axillary hair (HP:0100134)1.98197263
71Abnormality of secondary sexual hair (HP:0009888)1.98197263
72Abnormal respiratory epithelium morphology (HP:0012253)1.97805851
73Abnormal respiratory motile cilium morphology (HP:0005938)1.97805851
74Panhypogammaglobulinemia (HP:0003139)1.97134713
75Anencephaly (HP:0002323)1.96789735
76Median cleft lip (HP:0000161)1.95810640
77Chronic mucocutaneous candidiasis (HP:0002728)1.95603062
78Recurrent cutaneous fungal infections (HP:0011370)1.95603062
79Increased intramyocellular lipid droplets (HP:0012240)1.94657635
80B lymphocytopenia (HP:0010976)1.94610244
81Episodic fever (HP:0001954)1.92812731
82Chronic sinusitis (HP:0011109)1.91431136
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91126768
84Exertional dyspnea (HP:0002875)1.90189470
85Autoimmune hemolytic anemia (HP:0001890)1.89435937
86Parakeratosis (HP:0001036)1.88500453
87Hypoplasia of the thymus (HP:0000778)1.86993089
88Duplicated collecting system (HP:0000081)1.86086975
89Abnormality of alanine metabolism (HP:0010916)1.82631017
90Hyperalaninemia (HP:0003348)1.82631017
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82631017
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.80062931
93Tubular atrophy (HP:0000092)1.78699879
94Medial flaring of the eyebrow (HP:0010747)1.78611264
95Progressive microcephaly (HP:0000253)1.77214171
96Abnormality of the renal cortex (HP:0011035)1.76422838
97Glycosuria (HP:0003076)1.75656012
98Abnormality of urine glucose concentration (HP:0011016)1.75656012
99Focal motor seizures (HP:0011153)1.74964389
100Abnormality of DNA repair (HP:0003254)1.74454491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR3.53140478
2TSSK63.48689853
3MUSK3.45437453
4MAPK153.40284728
5TXK3.11735305
6GRK12.85598051
7ADRBK22.70886449
8TESK22.66012622
9MAP4K22.55195597
10VRK22.41411698
11TLK12.27746526
12SCYL22.26036110
13TAOK32.22995239
14VRK12.00795824
15TIE11.95080754
16FRK1.87541278
17PDK21.84137054
18WNK31.81033794
19MAPKAPK31.79087082
20WNK41.67620845
21PNCK1.65414438
22MAP3K121.64517047
23MAP4K11.52721330
24INSRR1.45924946
25GRK61.43938776
26SYK1.43345389
27TAF11.40437791
28CAMKK21.40139871
29TESK11.38579520
30ZAK1.32777510
31BTK1.24154266
32LIMK11.22861068
33EPHB21.19738330
34TEC1.19423861
35OXSR11.17918829
36NUAK11.13047225
37BMPR1B1.02590372
38ITK0.99733799
39STK390.95202283
40BMPR20.93604071
41PLK20.86612421
42PRKCQ0.85921907
43MAP3K110.84800081
44STK38L0.82289584
45RPS6KA50.80401241
46EPHB10.79657896
47MYLK0.78521602
48DAPK10.75383022
49TNK20.75025736
50MAPK130.73696551
51MAPKAPK50.73145899
52CSF1R0.71152866
53NEK10.70616631
54LCK0.67134394
55EIF2AK30.66079460
56GRK50.64165932
57BCKDK0.63353478
58PRKCG0.63210454
59ERBB20.60498922
60MATK0.60273502
61IKBKB0.58841503
62CLK10.58058070
63FES0.57187941
64MAP2K20.54218490
65CDK30.53525103
66LYN0.52595855
67ADRBK10.50790571
68CSK0.50297119
69DYRK20.49569860
70PTK2B0.49317748
71MAP2K60.48532664
72ZAP700.47703135
73CAMK2A0.45197806
74LATS10.43215626
75BUB10.43192588
76MAP3K40.43030884
77PLK30.42258676
78CSNK1A10.40599284
79PRKACA0.40558957
80CSNK1G30.39692710
81PHKG10.39549100
82PHKG20.39549100
83NME10.39488606
84PRKCE0.39028960
85CASK0.38891457
86NTRK30.38180734
87PIM10.37027459
88CAMK2D0.36828754
89OBSCN0.34083013
90RPS6KA40.32168485
91TBK10.30873063
92CSNK1A1L0.30807394
93NTRK10.30440918
94PRKCA0.30171226
95MAPKAPK20.29658406
96SRPK10.29049201
97IGF1R0.28712108
98CSNK1G10.28450894
99DAPK20.26087871
100PRKCH0.24678861

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.97987249
2Oxidative phosphorylation_Homo sapiens_hsa001903.74742592
3Proteasome_Homo sapiens_hsa030503.30906231
4Parkinsons disease_Homo sapiens_hsa050123.15214886
5Phototransduction_Homo sapiens_hsa047442.75376142
6Nitrogen metabolism_Homo sapiens_hsa009102.63417533
7Autoimmune thyroid disease_Homo sapiens_hsa053202.18450914
8Huntingtons disease_Homo sapiens_hsa050162.18083160
9Protein export_Homo sapiens_hsa030602.13755761
10Alzheimers disease_Homo sapiens_hsa050102.13253215
11Asthma_Homo sapiens_hsa053102.04654511
12Allograft rejection_Homo sapiens_hsa053302.02421470
13Ribosome_Homo sapiens_hsa030102.01219087
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.78693582
15Antigen processing and presentation_Homo sapiens_hsa046121.76429969
16Graft-versus-host disease_Homo sapiens_hsa053321.71694788
17Cardiac muscle contraction_Homo sapiens_hsa042601.69879624
18Type I diabetes mellitus_Homo sapiens_hsa049401.66473232
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63132460
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62557686
21RNA polymerase_Homo sapiens_hsa030201.62517877
22Hematopoietic cell lineage_Homo sapiens_hsa046401.61184415
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59152721
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54213392
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49080304
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.47747967
27Caffeine metabolism_Homo sapiens_hsa002321.38620234
28Fanconi anemia pathway_Homo sapiens_hsa034601.34504455
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32906356
30Collecting duct acid secretion_Homo sapiens_hsa049661.28602773
31Rheumatoid arthritis_Homo sapiens_hsa053231.26253869
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19599460
33T cell receptor signaling pathway_Homo sapiens_hsa046601.19025250
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17793321
35Nicotine addiction_Homo sapiens_hsa050331.14883951
36Linoleic acid metabolism_Homo sapiens_hsa005911.14550091
37Taste transduction_Homo sapiens_hsa047421.09222753
38Ether lipid metabolism_Homo sapiens_hsa005651.08714023
39Morphine addiction_Homo sapiens_hsa050321.07122792
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06324533
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05935473
42Basal transcription factors_Homo sapiens_hsa030221.04700771
43RNA degradation_Homo sapiens_hsa030181.04658410
44Chemical carcinogenesis_Homo sapiens_hsa052041.04647746
45Olfactory transduction_Homo sapiens_hsa047401.03727783
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02296378
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01588908
48Sulfur relay system_Homo sapiens_hsa041220.93793786
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88108949
50Tryptophan metabolism_Homo sapiens_hsa003800.86487131
51GABAergic synapse_Homo sapiens_hsa047270.85352550
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81119761
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80576228
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79359584
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76627410
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73452800
57Vitamin digestion and absorption_Homo sapiens_hsa049770.70052992
58Homologous recombination_Homo sapiens_hsa034400.67242446
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.66505901
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.65834224
61Insulin secretion_Homo sapiens_hsa049110.64493538
62Regulation of autophagy_Homo sapiens_hsa041400.64297858
63African trypanosomiasis_Homo sapiens_hsa051430.61373751
64Purine metabolism_Homo sapiens_hsa002300.59977450
65Retinol metabolism_Homo sapiens_hsa008300.59644105
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56601778
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55141244
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54701934
69Sulfur metabolism_Homo sapiens_hsa009200.54343928
70Mineral absorption_Homo sapiens_hsa049780.53622171
71Calcium signaling pathway_Homo sapiens_hsa040200.50935370
72Circadian entrainment_Homo sapiens_hsa047130.50092118
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.49821450
74Pyrimidine metabolism_Homo sapiens_hsa002400.49531160
75Butanoate metabolism_Homo sapiens_hsa006500.49314594
76Glycerolipid metabolism_Homo sapiens_hsa005610.48991802
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48423906
78Serotonergic synapse_Homo sapiens_hsa047260.48394725
79Glutamatergic synapse_Homo sapiens_hsa047240.48053744
80Peroxisome_Homo sapiens_hsa041460.47850848
81One carbon pool by folate_Homo sapiens_hsa006700.44340119
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43276502
83Prion diseases_Homo sapiens_hsa050200.42566866
84Metabolic pathways_Homo sapiens_hsa011000.41478892
85N-Glycan biosynthesis_Homo sapiens_hsa005100.40873570
86Amphetamine addiction_Homo sapiens_hsa050310.39463620
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38395722
88Propanoate metabolism_Homo sapiens_hsa006400.37105350
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36136193
90Staphylococcus aureus infection_Homo sapiens_hsa051500.34379323
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.34122940
92Viral myocarditis_Homo sapiens_hsa054160.31591176
93Fatty acid biosynthesis_Homo sapiens_hsa000610.30086953
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30077298
95Bile secretion_Homo sapiens_hsa049760.28060155
96Fat digestion and absorption_Homo sapiens_hsa049750.26921281
97Malaria_Homo sapiens_hsa051440.26658474
98Salivary secretion_Homo sapiens_hsa049700.26562372
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24889754
100Steroid biosynthesis_Homo sapiens_hsa001000.22432643

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