ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	spinal cord association neuron differentiation (GO:0021527)	6.78962693
2	centriole assembly (GO:0098534)	6.51668416
3	cell proliferation in forebrain (GO:0021846)	5.68493489
4	forebrain neuron differentiation (GO:0021879)	4.91858979
5	positive regulation of gastrulation (GO:2000543)	4.74517123
6	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	4.67560904
7	acrosome assembly (GO:0001675)	4.61687581
8	protein K6-linked ubiquitination (GO:0085020)	4.47207623
9	histone H3-K9 methylation (GO:0051567)	4.43056102
10	replicative senescence (GO:0090399)	4.08355233
11	opioid receptor signaling pathway (GO:0038003)	4.06027796
12	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.05553206
13	pharyngeal system development (GO:0060037)	4.04199338
14	sensory perception of smell (GO:0007608)	3.98443818
15	kynurenine metabolic process (GO:0070189)	3.95129579
16	cerebellar Purkinje cell differentiation (GO:0021702)	3.94417039
17	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.89138943
18	head development (GO:0060322)	3.86942411
19	cytoplasmic mRNA processing body assembly (GO:0033962)	3.80233990
20	neural tube formation (GO:0001841)	3.73621518
21	keratinocyte proliferation (GO:0043616)	3.73545203
22	histone H4-K12 acetylation (GO:0043983)	3.71430803
23	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.59359861
24	urogenital system development (GO:0001655)	3.57111259
25	protein K48-linked ubiquitination (GO:0070936)	3.56463619
26	serotonin metabolic process (GO:0042428)	3.56286408
27	indolalkylamine catabolic process (GO:0046218)	3.54079486
28	tryptophan catabolic process (GO:0006569)	3.54079486
29	indole-containing compound catabolic process (GO:0042436)	3.54079486
30	ubiquinone biosynthetic process (GO:0006744)	3.51724705
31	negative regulation of membrane potential (GO:0045837)	3.51165007
32	histone H3-K9 modification (GO:0061647)	3.48327790
33	cell differentiation in spinal cord (GO:0021515)	3.44118799
34	indolalkylamine metabolic process (GO:0006586)	3.42643813
35	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.41105808
36	peristalsis (GO:0030432)	3.40401731
37	genetic imprinting (GO:0071514)	3.39111687
38	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.34400181
39	regulation of mitotic spindle checkpoint (GO:1903504)	3.34400181
40	mechanoreceptor differentiation (GO:0042490)	3.32312250
41	regulation of gene expression by genetic imprinting (GO:0006349)	3.31046973
42	indole-containing compound metabolic process (GO:0042430)	3.26787358
43	behavioral response to nicotine (GO:0035095)	3.26660664
44	piRNA metabolic process (GO:0034587)	3.25003936
45	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.24129648
46	L-fucose catabolic process (GO:0042355)	3.22508068
47	fucose catabolic process (GO:0019317)	3.22508068
48	L-fucose metabolic process (GO:0042354)	3.22508068
49	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.21616678
50	somite development (GO:0061053)	3.21439256
51	ubiquinone metabolic process (GO:0006743)	3.18897223
52	forebrain morphogenesis (GO:0048853)	3.17659464
53	negative regulation of protein localization to cell surface (GO:2000009)	3.16369089
54	glycerophospholipid catabolic process (GO:0046475)	3.12250607
55	primary amino compound metabolic process (GO:1901160)	3.09501659
56	endoderm formation (GO:0001706)	3.08768321
57	locomotory exploration behavior (GO:0035641)	3.07812536
58	peptidyl-threonine dephosphorylation (GO:0035970)	3.05513397
59	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.01278048
60	negative regulation of multicellular organism growth (GO:0040015)	2.98067212
61	outer ear morphogenesis (GO:0042473)	2.97561406
62	segment specification (GO:0007379)	2.96789537
63	parturition (GO:0007567)	2.95538391
64	negative regulation of systemic arterial blood pressure (GO:0003085)	2.90755972
65	quinone biosynthetic process (GO:1901663)	2.90043323
66	tryptophan metabolic process (GO:0006568)	2.88767915
67	membrane depolarization during action potential (GO:0086010)	2.87611512
68	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.87054766
69	behavioral response to ethanol (GO:0048149)	2.86815103
70	interkinetic nuclear migration (GO:0022027)	2.84679704
71	innervation (GO:0060384)	2.79902115
72	regulation of mesoderm development (GO:2000380)	2.79863961
73	regulation of feeding behavior (GO:0060259)	2.78848843
74	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.78353184
75	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.76575314
76	regulation of prostaglandin secretion (GO:0032306)	2.76222063
77	peptidyl-histidine modification (GO:0018202)	2.74534806
78	mitochondrial genome maintenance (GO:0000002)	2.74351758
79	male meiosis I (GO:0007141)	2.71619766
80	negative regulation of axon extension (GO:0030517)	2.69541252
81	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.69480492
82	cellular response to exogenous dsRNA (GO:0071360)	2.69465842
83	negative regulation of gene silencing (GO:0060969)	2.69107857
84	DNA methylation involved in gamete generation (GO:0043046)	2.67238103
85	phospholipid catabolic process (GO:0009395)	2.66404280
86	skeletal muscle organ development (GO:0060538)	2.65562386
87	protein autoubiquitination (GO:0051865)	2.65435846
88	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.65283142
89	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.65283142
90	regulation of DNA methylation (GO:0044030)	2.65123287
91	amine catabolic process (GO:0009310)	2.64575791
92	cellular biogenic amine catabolic process (GO:0042402)	2.64575791
93	inositol phosphate dephosphorylation (GO:0046855)	2.63400451
94	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.63400451
95	regulation of collateral sprouting (GO:0048670)	2.62380023
96	sensory perception of chemical stimulus (GO:0007606)	2.62146422
97	neuronal action potential (GO:0019228)	2.59752173
98	cornea development in camera-type eye (GO:0061303)	2.58949476
99	pituitary gland development (GO:0021983)	2.58820549
100	motile cilium assembly (GO:0044458)	13.3635593

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.17642390
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.51588626
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.45765866
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.14985359
5	EWS_26573619_Chip-Seq_HEK293_Human	3.02818372
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.84999955
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.73203103
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.42267732
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.41157173
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.23182545
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.21210794
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.18207947
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07139585
14	RNF2_27304074_Chip-Seq_NSC_Mouse	1.99253375
15	FUS_26573619_Chip-Seq_HEK293_Human	1.95791988
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85540179
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.82412526
18	P300_19829295_ChIP-Seq_ESCs_Human	1.81159832
19	REST_21632747_ChIP-Seq_MESCs_Mouse	1.77328714
20	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76563324
21	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.76563324
22	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.68219851
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.62499423
24	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.61961271
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.61033552
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60834135
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.60277792
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.57272146
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56514238
30	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.55011305
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.53370786
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.53260575
33	RUNX2_22187159_ChIP-Seq_PCA_Human	1.49626155
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.47223613
35	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.45073858
36	STAT3_23295773_ChIP-Seq_U87_Human	1.44742064
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.43994882
38	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43257066
39	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.43018454
40	AR_21572438_ChIP-Seq_LNCaP_Human	1.38985350
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.38886013
42	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.37982974
43	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.37780386
44	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36740024
45	TCF4_23295773_ChIP-Seq_U87_Human	1.35616237
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35230583
47	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.34594292
48	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.33574446
49	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.31688066
50	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.31311285
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30425448
52	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.30396989
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.29235108
54	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.27291696
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27090289
56	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.26668964
57	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.25970125
58	HOXB7_26014856_ChIP-Seq_BT474_Human	1.25227355
59	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.25226665
60	DROSHA_22980978_ChIP-Seq_HELA_Human	1.24635905
61	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.24387663
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.24072031
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24072031
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23980632
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22837342
66	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.21469956
67	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21117459
68	ERA_21632823_ChIP-Seq_H3396_Human	1.19219912
69	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.18760906
70	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.18734398
71	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.18734398
72	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.18715881
73	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18638392
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18090864
75	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.17084859
76	TP53_16413492_ChIP-PET_HCT116_Human	1.16825314
77	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.15940747
78	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.15579325
79	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.15438184
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14957662
81	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.12772160
82	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.11059933
83	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.10873304
84	NCOR_22424771_ChIP-Seq_293T_Human	1.10694268
85	SMAD4_21799915_ChIP-Seq_A2780_Human	1.08329590
86	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.06718011
87	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.05329553
88	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03566483
89	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.02294720
90	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.02208447
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01559765
92	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01502769
93	TCF4_22108803_ChIP-Seq_LS180_Human	1.01157232
94	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.00650363
95	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.00525417
96	AR_25329375_ChIP-Seq_VCAP_Human	0.99443524
97	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98660003
98	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98127001
99	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.96623863
100	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96413525

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.44149174
2	MP0006292_abnormal_olfactory_placode	4.13849323
3	MP0003122_maternal_imprinting	3.11949248
4	MP0003123_paternal_imprinting	2.90457240
5	MP0001968_abnormal_touch/_nociception	2.82854969
6	MP0003121_genomic_imprinting	2.76312150
7	MP0004885_abnormal_endolymph	2.61194212
8	MP0004142_abnormal_muscle_tone	2.54405486
9	MP0001485_abnormal_pinna_reflex	2.53958940
10	MP0003787_abnormal_imprinting	2.53008032
11	MP0000427_abnormal_hair_cycle	2.51093813
12	MP0002653_abnormal_ependyma_morphology	2.41470628
13	MP0009046_muscle_twitch	2.28828722
14	MP0002736_abnormal_nociception_after	2.25602113
15	MP0003890_abnormal_embryonic-extraembry	2.22109838
16	MP0000631_abnormal_neuroendocrine_gland	2.19509099
17	MP0002735_abnormal_chemical_nociception	1.99774069
18	MP0009745_abnormal_behavioral_response	1.98342009
19	MP0008875_abnormal_xenobiotic_pharmacok	1.90443667
20	MP0005646_abnormal_pituitary_gland	1.82844432
21	MP0006276_abnormal_autonomic_nervous	1.82830926
22	MP0000778_abnormal_nervous_system	1.78579162
23	MP0005551_abnormal_eye_electrophysiolog	1.72965537
24	MP0004145_abnormal_muscle_electrophysio	1.67231915
25	MP0003183_abnormal_peptide_metabolism	1.64682150
26	MP0002272_abnormal_nervous_system	1.62587586
27	MP0002733_abnormal_thermal_nociception	1.56252360
28	MP0002184_abnormal_innervation	1.55116463
29	MP0002102_abnormal_ear_morphology	1.52483841
30	MP0003942_abnormal_urinary_system	1.51926383
31	MP0002067_abnormal_sensory_capabilities	1.51581539
32	MP0004859_abnormal_synaptic_plasticity	1.51412555
33	MP0001501_abnormal_sleep_pattern	1.47830180
34	MP0001440_abnormal_grooming_behavior	1.45098332
35	MP0003136_yellow_coat_color	1.44452652
36	MP0002064_seizures	1.44377289
37	MP0002572_abnormal_emotion/affect_behav	1.44183396
38	MP0005167_abnormal_blood-brain_barrier	1.42179968
39	MP0003646_muscle_fatigue	1.38121549
40	MP0002234_abnormal_pharynx_morphology	1.38095173
41	MP0004133_heterotaxia	1.33842616
42	MP0003879_abnormal_hair_cell	1.31813677
43	MP0002063_abnormal_learning/memory/cond	1.31160626
44	MP0001970_abnormal_pain_threshold	1.30562791
45	MP0002734_abnormal_mechanical_nocicepti	1.29824246
46	MP0008872_abnormal_physiological_respon	1.27615151
47	MP0009379_abnormal_foot_pigmentation	1.26541838
48	MP0001486_abnormal_startle_reflex	1.26128376
49	MP0000955_abnormal_spinal_cord	1.25629385
50	MP0003195_calcinosis	1.19832259
51	MP0000639_abnormal_adrenal_gland	1.19533327
52	MP0002837_dystrophic_cardiac_calcinosis	1.17567289
53	MP0000026_abnormal_inner_ear	1.14901610
54	MP0004019_abnormal_vitamin_homeostasis	1.11513381
55	MP0003635_abnormal_synaptic_transmissio	1.10199138
56	MP0000049_abnormal_middle_ear	1.09735297
57	MP0002557_abnormal_social/conspecific_i	1.08738898
58	MP0003880_abnormal_central_pattern	1.08685062
59	MP0003638_abnormal_response/metabolism_	1.08412596
60	MP0001963_abnormal_hearing_physiology	1.06468880
61	MP0002752_abnormal_somatic_nervous	1.04894441
62	MP0005389_reproductive_system_phenotype	1.01657998
63	MP0003861_abnormal_nervous_system	1.00060057
64	MP0002152_abnormal_brain_morphology	0.99759339
65	MP0004742_abnormal_vestibular_system	0.99686974
66	MP0002882_abnormal_neuron_morphology	0.99329238
67	MP0000678_abnormal_parathyroid_gland	0.99191546
68	MP0002210_abnormal_sex_determination	0.98297665
69	MP0001293_anophthalmia	0.96171455
70	MP0002095_abnormal_skin_pigmentation	0.95507000
71	MP0002876_abnormal_thyroid_physiology	0.94268441
72	MP0005195_abnormal_posterior_eye	0.93797624
73	MP0002160_abnormal_reproductive_system	0.92790859
74	MP0000534_abnormal_ureter_morphology	0.91528549
75	MP0003698_abnormal_male_reproductive	0.91288511
76	MP0004233_abnormal_muscle_weight	0.90635028
77	MP0004215_abnormal_myocardial_fiber	0.89865445
78	MP0002229_neurodegeneration	0.89845785
79	MP0001919_abnormal_reproductive_system	0.87304540
80	MP0010094_abnormal_chromosome_stability	0.86767153
81	MP0003937_abnormal_limbs/digits/tail_de	0.85748278
82	MP0001986_abnormal_taste_sensitivity	0.83312157
83	MP0003938_abnormal_ear_development	0.81512520
84	MP0010307_abnormal_tumor_latency	0.81303372
85	MP0000230_abnormal_systemic_arterial	0.81152204
86	MP0003137_abnormal_impulse_conducting	0.80029367
87	MP0004043_abnormal_pH_regulation	0.79905374
88	MP0009672_abnormal_birth_weight	0.79641397
89	MP0003632_abnormal_nervous_system	0.77043798
90	MP0004924_abnormal_behavior	0.76558428
91	MP0005386_behavior/neurological_phenoty	0.76558428
92	MP0002751_abnormal_autonomic_nervous	0.75159476
93	MP0001145_abnormal_male_reproductive	0.75026326
94	MP0008775_abnormal_heart_ventricle	0.74584717
95	MP0000653_abnormal_sex_gland	0.74468102
96	MP0003786_premature_aging	0.74334701
97	MP0004270_analgesia	0.74333738
98	MP0002066_abnormal_motor_capabilities/c	0.72650182
99	MP0002277_abnormal_respiratory_mucosa	0.71916922
100	MP0004811_abnormal_neuron_physiology	0.71240510

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	5.15361415
2	Molar tooth sign on MRI (HP:0002419)	3.88838702
3	Abnormality of midbrain morphology (HP:0002418)	3.88838702
4	Chromsome breakage (HP:0040012)	3.85353045
5	Flat cornea (HP:0007720)	3.81706289
6	Sclerocornea (HP:0000647)	3.81438148
7	Type II lissencephaly (HP:0007260)	3.65544120
8	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.46159416
9	Absent/shortened dynein arms (HP:0200106)	3.46159416
10	Type 2 muscle fiber atrophy (HP:0003554)	3.41290939
11	Keratoconus (HP:0000563)	3.20370738
12	Increased corneal curvature (HP:0100692)	3.20370738
13	Pancreatic cysts (HP:0001737)	3.12889283
14	Polyuria (HP:0000103)	3.11898529
15	Acute lymphatic leukemia (HP:0006721)	3.06511050
16	Pancreatic fibrosis (HP:0100732)	2.84745331
17	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.78936172
18	Abnormality of alanine metabolism (HP:0010916)	2.78936172
19	Hyperalaninemia (HP:0003348)	2.78936172
20	Visual hallucinations (HP:0002367)	2.76125361
21	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.75039940
22	Abnormality of the renal cortex (HP:0011035)	2.74585044
23	Abnormal drinking behavior (HP:0030082)	2.74032587
24	Polydipsia (HP:0001959)	2.74032587
25	Abnormal ciliary motility (HP:0012262)	2.73647488
26	True hermaphroditism (HP:0010459)	2.73461352
27	Progressive inability to walk (HP:0002505)	2.73391465
28	Chronic hepatic failure (HP:0100626)	2.66738925
29	Cerebellar dysplasia (HP:0007033)	2.64585725
30	Muscle fiber atrophy (HP:0100295)	2.62033711
31	Decreased circulating renin level (HP:0003351)	2.61641006
32	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.61031033
33	Hypoplasia of the pons (HP:0012110)	2.60433803
34	Abnormal urine output (HP:0012590)	2.59284661
35	Inability to walk (HP:0002540)	2.58541797
36	Hyperventilation (HP:0002883)	2.54550966
37	Nephronophthisis (HP:0000090)	2.53765391
38	Abnormality of renal excretion (HP:0011036)	2.53109309
39	Increased number of teeth (HP:0011069)	2.50382331
40	Volvulus (HP:0002580)	2.43380783
41	Hypothermia (HP:0002045)	2.42394456
42	Truncal obesity (HP:0001956)	2.40860446
43	Hypomagnesemia (HP:0002917)	2.39218689
44	Abnormal respiratory epithelium morphology (HP:0012253)	2.38152436
45	Abnormal respiratory motile cilium morphology (HP:0005938)	2.38152436
46	Meckel diverticulum (HP:0002245)	2.36984158
47	Tubular atrophy (HP:0000092)	2.33315459
48	Oligodactyly (hands) (HP:0001180)	2.28986159
49	Abnormality of the renal medulla (HP:0100957)	2.25662373
50	Optic nerve hypoplasia (HP:0000609)	2.25515575
51	Epileptic encephalopathy (HP:0200134)	2.23716769
52	Abnormality of chromosome stability (HP:0003220)	2.23533518
53	Abnormality of the ileum (HP:0001549)	2.21249073
54	Male pseudohermaphroditism (HP:0000037)	2.17020715
55	Osteomalacia (HP:0002749)	2.16526546
56	Abnormality of the pons (HP:0007361)	2.16481871
57	Abnormal eating behavior (HP:0100738)	2.16097251
58	Pendular nystagmus (HP:0012043)	2.14986920
59	Protruding tongue (HP:0010808)	2.11686735
60	Shawl scrotum (HP:0000049)	2.09568342
61	Renal salt wasting (HP:0000127)	2.06824099
62	Abnormality of the nasal septum (HP:0000419)	2.05814500
63	Alkalosis (HP:0001948)	2.04399328
64	Delayed myelination (HP:0012448)	2.01835972
65	Abnormality of the carotid arteries (HP:0005344)	2.01317344
66	Septo-optic dysplasia (HP:0100842)	2.00141972
67	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.00038471
68	Urinary bladder sphincter dysfunction (HP:0002839)	1.98175343
69	Patellar aplasia (HP:0006443)	1.95916759
70	Abnormal hair whorl (HP:0010721)	1.93295307
71	Anophthalmia (HP:0000528)	1.93147758
72	Occipital encephalocele (HP:0002085)	1.92950638
73	Abnormal respiratory motile cilium physiology (HP:0012261)	1.91802661
74	Cystic liver disease (HP:0006706)	1.90933482
75	Irregular vertebral endplates (HP:0003301)	1.89657714
76	Hip contracture (HP:0003273)	1.87422938
77	Bilateral microphthalmos (HP:0007633)	1.87188961
78	Scrotal hypoplasia (HP:0000046)	1.87030304
79	Chorioretinal atrophy (HP:0000533)	1.86587416
80	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.86578726
81	Aplasia/Hypoplasia of the patella (HP:0006498)	1.85280067
82	Gaze-evoked nystagmus (HP:0000640)	1.84732724
83	Ulnar claw (HP:0001178)	1.84593021
84	Abnormality of the axillary hair (HP:0100134)	1.84536459
85	Abnormality of secondary sexual hair (HP:0009888)	1.84536459
86	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84069542
87	Hyperglycinuria (HP:0003108)	1.82542131
88	Bundle branch block (HP:0011710)	1.81643610
89	Reticulocytopenia (HP:0001896)	1.81579288
90	Progressive cerebellar ataxia (HP:0002073)	1.78495817
91	Rib fusion (HP:0000902)	1.77800738
92	Tachypnea (HP:0002789)	1.77764295
93	Focal motor seizures (HP:0011153)	1.76104652
94	Prostate neoplasm (HP:0100787)	1.75061591
95	Abnormality of the preputium (HP:0100587)	1.74305505
96	Lissencephaly (HP:0001339)	1.74121394
97	Fetal akinesia sequence (HP:0001989)	1.73567505
98	Hyperaldosteronism (HP:0000859)	1.72515491
99	Supernumerary spleens (HP:0009799)	1.71981839
100	Medial flaring of the eyebrow (HP:0010747)	1.71273363

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	5.54290581
2	FRK	4.87883208
3	ACVR1B	3.90593597
4	MKNK2	3.51350114
5	BMPR1B	3.45450393
6	ADRBK2	3.32146891
7	ZAK	3.20870293
8	NUAK1	2.73956611
9	TAOK3	2.62340543
10	TRIM28	2.28672960
11	WNK4	2.20038975
12	MUSK	2.06611093
13	SIK2	1.98026200
14	MKNK1	1.90279676
15	ADRBK1	1.81967280
16	TNIK	1.80373931
17	CASK	1.79795604
18	PINK1	1.75390081
19	PIK3CA	1.60302713
20	TGFBR1	1.59014303
21	TAOK1	1.54881633
22	MAPKAPK3	1.53712362
23	GRK1	1.35699996
24	PNCK	1.34652193
25	CHEK2	1.20070320
26	PTK2B	1.19257947
27	CDK7	1.17963833
28	TTK	1.14055803
29	WNK3	1.13330600
30	GRK5	1.00906689
31	CAMKK2	0.96994921
32	STK39	0.93005454
33	NTRK2	0.90244452
34	OXSR1	0.84876182
35	DAPK2	0.84545871
36	NEK2	0.82430900
37	PLK2	0.81816919
38	IRAK2	0.77589013
39	MAPK13	0.77346224
40	MST4	0.73468330
41	NME1	0.72903122
42	PDK2	0.72520313
43	CAMK2A	0.70905420
44	MAP2K7	0.70288417
45	TIE1	0.70149455
46	DYRK2	0.70029783
47	AURKA	0.68637466
48	PRKCG	0.68595464
49	PLK1	0.68021936
50	MAPK11	0.66730072
51	LATS1	0.66576032
52	TAF1	0.64957303
53	MELK	0.63328546
54	SGK1	0.58838126
55	CAMK1	0.58256795
56	MARK1	0.55547046
57	CAMK1G	0.54323980
58	MARK2	0.52354009
59	MAP2K4	0.51837190
60	INSRR	0.51386227
61	MAP3K4	0.50122145
62	STK11	0.49949171
63	PLK3	0.49364169
64	PRKCI	0.49287020
65	TRPM7	0.45876033
66	ALK	0.42363040
67	SGK494	0.41509485
68	SGK223	0.41509485
69	MAPKAPK5	0.41457056
70	PRKACA	0.41167971
71	PRKCH	0.37343995
72	PAK3	0.36548522
73	PRKACG	0.36304810
74	PRKCE	0.34675720
75	IKBKE	0.34365094
76	CDK4	0.33931453
77	MAP2K6	0.33666844
78	CAMK2B	0.33056697
79	CAMK1D	0.32277744
80	STK3	0.32014720
81	EEF2K	0.31878706
82	PRKCQ	0.31216300
83	VRK2	0.31034324
84	CHUK	0.30462234
85	CSNK1E	0.30358380
86	VRK1	0.30237329
87	NTRK3	0.29934328
88	PIK3CG	0.28997714
89	SGK3	0.28956435
90	CSNK1G2	0.28895285
91	ABL2	0.27897807
92	ATM	0.27892035
93	PRKDC	0.27735921
94	SGK2	0.26770013
95	IRAK4	0.26581060
96	ATR	0.26287464
97	MAPK14	0.25302875
98	PRKAA2	0.24711286
99	PRKACB	0.24672239
100	RPS6KA3	0.23203920

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.52053950
2	Linoleic acid metabolism_Homo sapiens_hsa00591	3.27728945
3	Phototransduction_Homo sapiens_hsa04744	3.05567610
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.46531913
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.44355330
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.35091429
7	Homologous recombination_Homo sapiens_hsa03440	2.33382876
8	Ether lipid metabolism_Homo sapiens_hsa00565	2.21751523
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.19343789
10	Nicotine addiction_Homo sapiens_hsa05033	2.18589955
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.15532546
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.04562184
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.98840900
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.95360074
15	Olfactory transduction_Homo sapiens_hsa04740	1.90483987
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.86444308
17	Morphine addiction_Homo sapiens_hsa05032	1.86248252
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.80569607
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.79767791
20	Basal cell carcinoma_Homo sapiens_hsa05217	1.69492902
21	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.68845146
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.66564793
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.65728052
24	Basal transcription factors_Homo sapiens_hsa03022	1.64090273
25	GABAergic synapse_Homo sapiens_hsa04727	1.45273041
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.44751665
27	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.44613950
28	Butanoate metabolism_Homo sapiens_hsa00650	1.42878477
29	Glutamatergic synapse_Homo sapiens_hsa04724	1.42625204
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.38790224
31	Serotonergic synapse_Homo sapiens_hsa04726	1.33766437
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.32134687
33	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.30054481
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.27198568
35	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.23609700
36	Circadian entrainment_Homo sapiens_hsa04713	1.20511700
37	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.19711919
38	Parkinsons disease_Homo sapiens_hsa05012	1.19007475
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.18536617
40	Taste transduction_Homo sapiens_hsa04742	1.17835740
41	Huntingtons disease_Homo sapiens_hsa05016	1.11809766
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.09451786
43	Ribosome_Homo sapiens_hsa03010	1.08049718
44	Caffeine metabolism_Homo sapiens_hsa00232	1.06416988
45	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.05289546
46	Protein export_Homo sapiens_hsa03060	1.03815764
47	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.02052374
48	Alzheimers disease_Homo sapiens_hsa05010	0.98109908
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.90464694
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.89842323
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.87778057
52	Insulin secretion_Homo sapiens_hsa04911	0.87257070
53	Hippo signaling pathway_Homo sapiens_hsa04390	0.86218670
54	RNA degradation_Homo sapiens_hsa03018	0.84997237
55	Long-term depression_Homo sapiens_hsa04730	0.84153598
56	Dopaminergic synapse_Homo sapiens_hsa04728	0.82179945
57	Propanoate metabolism_Homo sapiens_hsa00640	0.80257635
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80052793
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78285522
60	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.78077001
61	Peroxisome_Homo sapiens_hsa04146	0.77347255
62	Fatty acid degradation_Homo sapiens_hsa00071	0.75365254
63	Retinol metabolism_Homo sapiens_hsa00830	0.72422580
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70048523
65	Circadian rhythm_Homo sapiens_hsa04710	0.69901147
66	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.69204146
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.68898382
68	Cocaine addiction_Homo sapiens_hsa05030	0.67573327
69	Non-homologous end-joining_Homo sapiens_hsa03450	0.66855100
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.66121256
71	Cholinergic synapse_Homo sapiens_hsa04725	0.65133560
72	Asthma_Homo sapiens_hsa05310	0.61129441
73	ABC transporters_Homo sapiens_hsa02010	0.57530011
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55748661
75	Salivary secretion_Homo sapiens_hsa04970	0.55016045
76	Regulation of autophagy_Homo sapiens_hsa04140	0.52269201
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.51935695
78	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.51479625
79	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.46430517
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45458661
81	Mineral absorption_Homo sapiens_hsa04978	0.44990235
82	Steroid biosynthesis_Homo sapiens_hsa00100	0.43894758
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.43717962
84	Melanogenesis_Homo sapiens_hsa04916	0.41932585
85	Metabolic pathways_Homo sapiens_hsa01100	0.41864420
86	RNA transport_Homo sapiens_hsa03013	0.40776849
87	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.40543898
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.38687430
89	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.37830382
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37588402
91	Wnt signaling pathway_Homo sapiens_hsa04310	0.37343398
92	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.34750228
93	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.34302809
94	Axon guidance_Homo sapiens_hsa04360	0.33545625
95	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.32497412
96	Type II diabetes mellitus_Homo sapiens_hsa04930	0.32131956
97	Pancreatic secretion_Homo sapiens_hsa04972	0.30938070
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.30798895
99	Ras signaling pathway_Homo sapiens_hsa04014	0.29930807
100	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.27619513

RBMX2P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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