RBMXL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents a retrogene of RNA binding motif protein, X-linked (RBMX), which is located on chromosome X. While all introns in the coding sequence have been processed out compared to the RBMX locus, the ORF is intact and there is specific evidence for transcription at this location. The preservation of the ORF by purifying selection in all Old World monkeys carrying it suggests that this locus is likely to be functional, possibly during male meiosis when X chromosomal genes are silenced or during haploid stages of spermatogenesis. This gene shares 5' exon structure with the cysteine conjugate-beta lyase 2 locus on chromosome 1, but the coding sequences are non-overlapping. Alternative splicing results in two transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.33500623
2DNA strand elongation involved in DNA replication (GO:0006271)5.29090095
3DNA strand elongation (GO:0022616)5.02291291
4DNA replication initiation (GO:0006270)4.91251623
5telomere maintenance via semi-conservative replication (GO:0032201)4.76359605
6ribosomal small subunit assembly (GO:0000028)4.71534002
7maturation of SSU-rRNA (GO:0030490)4.59837937
8formation of translation preinitiation complex (GO:0001731)4.48076570
9DNA double-strand break processing (GO:0000729)4.31367541
10viral transcription (GO:0019083)4.30402014
11nucleobase biosynthetic process (GO:0046112)4.29962281
12negative regulation of DNA-dependent DNA replication (GO:2000104)4.24545063
13translational termination (GO:0006415)4.24122526
14telomere maintenance via recombination (GO:0000722)4.20575518
15protein localization to kinetochore (GO:0034501)4.16671413
16mitotic sister chromatid cohesion (GO:0007064)4.16628426
17DNA replication checkpoint (GO:0000076)4.09391478
18mitotic recombination (GO:0006312)4.05530244
19translational elongation (GO:0006414)3.91485051
20purine nucleobase biosynthetic process (GO:0009113)3.91040404
21ribosomal small subunit biogenesis (GO:0042274)3.90183233
22ribosomal large subunit biogenesis (GO:0042273)3.89913514
23DNA replication-dependent nucleosome assembly (GO:0006335)3.88761745
24DNA replication-dependent nucleosome organization (GO:0034723)3.88761745
25mitotic metaphase plate congression (GO:0007080)3.88383123
26telomere maintenance via telomere lengthening (GO:0010833)3.86110570
27IMP biosynthetic process (GO:0006188)3.83247124
28translational initiation (GO:0006413)3.82873993
29nucleotide-excision repair, DNA gap filling (GO:0006297)3.79304310
30DNA deamination (GO:0045006)3.78501224
31regulation of helicase activity (GO:0051095)3.73258242
32CENP-A containing nucleosome assembly (GO:0034080)3.73005807
33mitotic nuclear envelope disassembly (GO:0007077)3.72758410
34folic acid-containing compound biosynthetic process (GO:0009396)3.72153042
35chromatin remodeling at centromere (GO:0031055)3.69412453
36ribonucleoprotein complex biogenesis (GO:0022613)3.68996027
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.67525948
38ribosome assembly (GO:0042255)3.65756256
39spliceosomal snRNP assembly (GO:0000387)3.64593057
40establishment of integrated proviral latency (GO:0075713)3.59635086
41ribosome biogenesis (GO:0042254)3.57664020
42DNA replication-independent nucleosome organization (GO:0034724)3.55864936
43DNA replication-independent nucleosome assembly (GO:0006336)3.55864936
44regulation of centriole replication (GO:0046599)3.55605669
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.54521854
46replication fork processing (GO:0031297)3.54001927
47protein localization to chromosome, centromeric region (GO:0071459)3.53548207
48regulation of DNA endoreduplication (GO:0032875)3.52546474
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.50580488
50negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.50255264
51tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.49883256
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.49883256
53regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.49870451
54regulation of mitotic spindle checkpoint (GO:1903504)3.49870451
55kinetochore organization (GO:0051383)3.49022315
56DNA catabolic process, exonucleolytic (GO:0000738)3.47803506
57cotranslational protein targeting to membrane (GO:0006613)3.45429817
58protein targeting to ER (GO:0045047)3.43864180
59membrane disassembly (GO:0030397)3.43509760
60nuclear envelope disassembly (GO:0051081)3.43509760
61maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.43275536
62mitochondrial RNA metabolic process (GO:0000959)3.43232272
63metaphase plate congression (GO:0051310)3.42856829
64IMP metabolic process (GO:0046040)3.40505207
65cellular protein complex disassembly (GO:0043624)3.39495844
66rRNA processing (GO:0006364)3.38810046
67negative regulation of RNA splicing (GO:0033119)3.37723554
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.35525218
69viral life cycle (GO:0019058)3.34773554
70spindle checkpoint (GO:0031577)3.31830674
71DNA duplex unwinding (GO:0032508)3.30890674
72DNA geometric change (GO:0032392)3.28897701
73nuclear pore organization (GO:0006999)3.28803349
74somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.28319525
75isotype switching (GO:0045190)3.28319525
76somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.28319525
77mitotic spindle checkpoint (GO:0071174)3.28277970
78rRNA metabolic process (GO:0016072)3.27552642
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26995035
80negative regulation of translation, ncRNA-mediated (GO:0040033)3.25752234
81regulation of translation, ncRNA-mediated (GO:0045974)3.25752234
82negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.25752234
83establishment of protein localization to endoplasmic reticulum (GO:0072599)3.25513299
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.25340313
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25340313
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24347386
87spliceosomal complex assembly (GO:0000245)3.22892949
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22532827
89RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.21148469
90mRNA splicing, via spliceosome (GO:0000398)3.21148469
91RNA splicing, via transesterification reactions (GO:0000375)3.20705124
92mitotic G2/M transition checkpoint (GO:0044818)3.20603488
93protein localization to endoplasmic reticulum (GO:0070972)3.20215636
94non-recombinational repair (GO:0000726)3.19540223
95double-strand break repair via nonhomologous end joining (GO:0006303)3.19540223
96negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17148719
97acrosome assembly (GO:0001675)3.16983482
98protein complex disassembly (GO:0043241)3.16927009
99mitotic sister chromatid segregation (GO:0000070)3.16835258
100viral mRNA export from host cell nucleus (GO:0046784)3.15739624
101anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15551918
102transcription-coupled nucleotide-excision repair (GO:0006283)3.15293772
103kinetochore assembly (GO:0051382)3.14719035
104histone exchange (GO:0043486)3.14673243
105pore complex assembly (GO:0046931)3.13814570
106histone mRNA metabolic process (GO:0008334)3.12661385
107establishment of chromosome localization (GO:0051303)3.12208894
108DNA ligation (GO:0006266)3.10195874
109pseudouridine synthesis (GO:0001522)3.10105910
110mitotic chromosome condensation (GO:0007076)3.08326265
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07934757
112centriole replication (GO:0007099)3.06791288
113transcription from mitochondrial promoter (GO:0006390)3.04607450
114G1/S transition of mitotic cell cycle (GO:0000082)3.04444566
115cell cycle G1/S phase transition (GO:0044843)3.04444566
116DNA-dependent DNA replication (GO:0006261)3.03645528
117proteasome assembly (GO:0043248)3.02758564
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02587526
119termination of RNA polymerase II transcription (GO:0006369)3.02115175
120nuclear-transcribed mRNA catabolic process (GO:0000956)3.01944017
121spindle assembly checkpoint (GO:0071173)3.01612500
122attachment of spindle microtubules to kinetochore (GO:0008608)3.01415187
123regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01406738
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01406738
125regulation of spindle organization (GO:0090224)3.01266769
126macromolecular complex disassembly (GO:0032984)3.00187740
127mitotic spindle assembly checkpoint (GO:0007094)3.00039918
128nuclear pore complex assembly (GO:0051292)2.99913729
129translesion synthesis (GO:0019985)2.99589952
130postreplication repair (GO:0006301)2.99472273
131negative regulation of mRNA processing (GO:0050686)2.98771824
132sister chromatid segregation (GO:0000819)2.97413620
133regulation of mitotic sister chromatid separation (GO:0010965)2.96619572
134regulation of mitotic sister chromatid segregation (GO:0033047)2.96619572
135regulation of sister chromatid segregation (GO:0033045)2.96619572
136translation (GO:0006412)2.96315037
137negative regulation of chromosome segregation (GO:0051985)2.96105842
138rRNA methylation (GO:0031167)2.96073623
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94899249
140negative regulation of sister chromatid segregation (GO:0033046)2.94899249
141negative regulation of mitotic sister chromatid separation (GO:2000816)2.94899249
142negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94899249
143telomere organization (GO:0032200)2.94185328
144DNA damage response, detection of DNA damage (GO:0042769)2.92247583
145recombinational repair (GO:0000725)2.91175494
146double-strand break repair via homologous recombination (GO:0000724)2.90217066
147synapsis (GO:0007129)2.90114954
148mitotic G2 DNA damage checkpoint (GO:0007095)2.88885939
149negative regulation of DNA recombination (GO:0045910)2.87449844
150alternative mRNA splicing, via spliceosome (GO:0000380)2.84158165
151RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82041839
152protein prenylation (GO:0018342)2.81628904
153prenylation (GO:0097354)2.81628904
154rRNA modification (GO:0000154)2.81248056
155regulation of nuclear cell cycle DNA replication (GO:0033262)2.78760291
156mRNA splice site selection (GO:0006376)2.77934287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.18319806
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.58465282
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.97379464
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.90322175
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80490796
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19242117
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.12763388
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09041940
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.06175571
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.01689995
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.95702725
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93756936
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.80711040
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.79695053
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69780739
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.65293300
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62530048
18XRN2_22483619_ChIP-Seq_HELA_Human2.51182343
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44129570
20FUS_26573619_Chip-Seq_HEK293_Human2.39034490
21EWS_26573619_Chip-Seq_HEK293_Human2.38592103
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31091592
23VDR_23849224_ChIP-Seq_CD4+_Human2.19412805
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16957734
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16798073
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11142590
27AR_21909140_ChIP-Seq_LNCAP_Human2.11105636
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06104696
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04485664
30E2F1_21310950_ChIP-Seq_MCF-7_Human2.03249905
31EGR1_19374776_ChIP-ChIP_THP-1_Human2.02127490
32DCP1A_22483619_ChIP-Seq_HELA_Human1.99300414
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98705245
34TTF2_22483619_ChIP-Seq_HELA_Human1.98626349
35FOXP3_21729870_ChIP-Seq_TREG_Human1.98039636
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97635150
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.94099057
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91038881
39TAF15_26573619_Chip-Seq_HEK293_Human1.89243508
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88809066
41GABP_19822575_ChIP-Seq_HepG2_Human1.88583716
42VDR_22108803_ChIP-Seq_LS180_Human1.87970815
43ZNF274_21170338_ChIP-Seq_K562_Hela1.85762232
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78749703
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77529488
46MYC_22102868_ChIP-Seq_BL_Human1.75679026
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74988342
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73480079
49CIITA_25753668_ChIP-Seq_RAJI_Human1.71698929
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69337759
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68809608
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68004283
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66104616
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65152503
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63858673
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61177283
57* ELK1_19687146_ChIP-ChIP_HELA_Human1.59037283
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56453889
59P300_19829295_ChIP-Seq_ESCs_Human1.56379199
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.55096518
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51295502
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50733079
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50227977
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48110437
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47668425
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43777993
67KDM5A_27292631_Chip-Seq_BREAST_Human1.39701975
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39411622
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.39120065
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33740509
71IGF1R_20145208_ChIP-Seq_DFB_Human1.33376264
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33140246
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30999171
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.27554633
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26589283
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26417912
77GBX2_23144817_ChIP-Seq_PC3_Human1.26067383
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25119963
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25096091
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23994765
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23158945
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22752880
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.20980092
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20327286
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18617655
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17987464
87IRF1_19129219_ChIP-ChIP_H3396_Human1.17776016
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17509394
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17155320
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15382172
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14701464
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14448454
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13641331
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12702386
95TFEB_21752829_ChIP-Seq_HELA_Human1.12096544
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10789891
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09176897
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08946552
99VDR_21846776_ChIP-Seq_THP-1_Human1.08500818
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08485821
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07355074
102NANOG_16153702_ChIP-ChIP_HESCs_Human1.06960170
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06450592
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06362053
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.05386086
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02940783
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02505543
108MYC_18940864_ChIP-ChIP_HL60_Human1.02297886
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.01077847
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00556797
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99672706
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99161223
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98949891
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97883605
115CBP_20019798_ChIP-Seq_JUKART_Human0.97883605
116NFE2_27457419_Chip-Seq_LIVER_Mouse0.96291910
117CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95719222
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95016910
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94885072
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94023866
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93578732
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92913226
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92553144
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92527105
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92170131
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89858751
127TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89550980
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.89327307
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88986143
130WT1_19549856_ChIP-ChIP_CCG9911_Human0.88594413
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87892987
132TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87644226
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86329410
134NANOG_21062744_ChIP-ChIP_HESCs_Human0.86301438
135HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86228799
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85445952
137PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85375484
138SALL4_22934838_ChIP-ChIP_CD34+_Human0.84703721
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84559415
140ELK1_22589737_ChIP-Seq_MCF10A_Human0.84345888
141CRX_20693478_ChIP-Seq_RETINA_Mouse0.83302824
142SPI1_23547873_ChIP-Seq_NB4_Human0.82977437
143ER_23166858_ChIP-Seq_MCF-7_Human0.82780616
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.82469240
145KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82366309
146OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82322713
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81055452
148ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79226243
149HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79058474
150SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77330235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.24283785
2MP0010094_abnormal_chromosome_stability4.84984358
3MP0004957_abnormal_blastocyst_morpholog4.58611280
4MP0003111_abnormal_nucleus_morphology4.42677498
5MP0008057_abnormal_DNA_replication4.11273672
6MP0003077_abnormal_cell_cycle4.10265371
7MP0008058_abnormal_DNA_repair3.49932997
8MP0008007_abnormal_cellular_replicative2.95473799
9MP0008932_abnormal_embryonic_tissue2.86952304
10MP0003123_paternal_imprinting2.78937683
11MP0009697_abnormal_copulation2.66684239
12MP0000569_abnormal_digit_pigmentation2.61441299
13MP0001730_embryonic_growth_arrest2.46166282
14MP0002396_abnormal_hematopoietic_system2.42407201
15MP0000350_abnormal_cell_proliferation2.34034718
16MP0010352_gastrointestinal_tract_polyps2.15224649
17MP0003136_yellow_coat_color2.09043171
18MP0010030_abnormal_orbit_morphology1.98964814
19MP0008995_early_reproductive_senescence1.90551440
20MP0008877_abnormal_DNA_methylation1.82696964
21MP0001697_abnormal_embryo_size1.82206058
22MP0003786_premature_aging1.80281979
23MP0000490_abnormal_crypts_of1.78770212
24MP0001672_abnormal_embryogenesis/_devel1.78139330
25MP0005380_embryogenesis_phenotype1.78139330
26MP0003121_genomic_imprinting1.71968265
27MP0002080_prenatal_lethality1.68915657
28MP0002085_abnormal_embryonic_tissue1.68065127
29MP0010307_abnormal_tumor_latency1.63117686
30MP0003984_embryonic_growth_retardation1.61696163
31MP0003567_abnormal_fetal_cardiomyocyte1.58806777
32MP0004808_abnormal_hematopoietic_stem1.58196195
33MP0002088_abnormal_embryonic_growth/wei1.58116302
34MP0002084_abnormal_developmental_patter1.56355620
35MP0000313_abnormal_cell_death1.50713003
36MP0004197_abnormal_fetal_growth/weight/1.48454109
37MP0001188_hyperpigmentation1.48260691
38MP0000537_abnormal_urethra_morphology1.43302177
39MP0001293_anophthalmia1.42305745
40MP0002019_abnormal_tumor_incidence1.41180415
41MP0002009_preneoplasia1.40598794
42MP0002086_abnormal_extraembryonic_tissu1.38660028
43MP0002736_abnormal_nociception_after1.38657941
44MP0009053_abnormal_anal_canal1.38233449
45MP0000372_irregular_coat_pigmentation1.35024408
46MP0002638_abnormal_pupillary_reflex1.32532601
47MP0006072_abnormal_retinal_apoptosis1.31100698
48MP0005253_abnormal_eye_physiology1.30995536
49MP0000647_abnormal_sebaceous_gland1.27294501
50MP0003890_abnormal_embryonic-extraembry1.26316098
51MP0009333_abnormal_splenocyte_physiolog1.24900989
52MP0000631_abnormal_neuroendocrine_gland1.24071753
53MP0000516_abnormal_urinary_system1.23758248
54MP0005367_renal/urinary_system_phenotyp1.23758248
55MP0006054_spinal_hemorrhage1.23168050
56MP0006292_abnormal_olfactory_placode1.22530039
57MP0003315_abnormal_perineum_morphology1.21640672
58MP0002277_abnormal_respiratory_mucosa1.19494290
59MP0002653_abnormal_ependyma_morphology1.18510226
60MP0005397_hematopoietic_system_phenotyp1.18333705
61MP0001545_abnormal_hematopoietic_system1.18333705
62MP0004133_heterotaxia1.17905149
63MP0002095_abnormal_skin_pigmentation1.17069043
64MP0000703_abnormal_thymus_morphology1.13573099
65MP0006035_abnormal_mitochondrial_morpho1.12329128
66MP0005076_abnormal_cell_differentiation1.10140695
67MP0003119_abnormal_digestive_system1.08168082
68MP0005391_vision/eye_phenotype1.08030639
69MP0005187_abnormal_penis_morphology1.03615023
70MP0002938_white_spotting1.02027839
71MP0002210_abnormal_sex_determination1.01778166
72MP0003763_abnormal_thymus_physiology1.01648455
73MP0003718_maternal_effect1.01583209
74MP0002102_abnormal_ear_morphology1.00556540
75MP0002398_abnormal_bone_marrow0.99784692
76MP0002233_abnormal_nose_morphology0.97631343
77MP0002722_abnormal_immune_system0.95425472
78MP0001145_abnormal_male_reproductive0.93654848
79MP0005075_abnormal_melanosome_morpholog0.92941904
80MP0005248_abnormal_Harderian_gland0.92464959
81MP0002111_abnormal_tail_morphology0.90157621
82MP0005174_abnormal_tail_pigmentation0.89234140
83MP0000689_abnormal_spleen_morphology0.89156979
84MP0000358_abnormal_cell_content/0.88936613
85MP0005084_abnormal_gallbladder_morpholo0.88831508
86MP0004215_abnormal_myocardial_fiber0.88538829
87MP0003806_abnormal_nucleotide_metabolis0.87225983
88MP0002160_abnormal_reproductive_system0.84256349
89MP0003937_abnormal_limbs/digits/tail_de0.82920871
90MP0000049_abnormal_middle_ear0.82775091
91MP0002090_abnormal_vision0.82632488
92MP0003943_abnormal_hepatobiliary_system0.81675260
93MP0001915_intracranial_hemorrhage0.80589686
94MP0001529_abnormal_vocalization0.79537622
95MP0009672_abnormal_birth_weight0.79290840
96MP0002429_abnormal_blood_cell0.78216453
97MP0000428_abnormal_craniofacial_morphol0.78028037
98MP0008789_abnormal_olfactory_epithelium0.77185955
99MP0009379_abnormal_foot_pigmentation0.77105485
100MP0001764_abnormal_homeostasis0.76997814
101MP0005384_cellular_phenotype0.76894366
102MP0003122_maternal_imprinting0.76323748
103MP0005394_taste/olfaction_phenotype0.76203204
104MP0005499_abnormal_olfactory_system0.76203204
105MP0001919_abnormal_reproductive_system0.75906417
106MP0001324_abnormal_eye_pigmentation0.75503161
107MP0002092_abnormal_eye_morphology0.75410393
108MP0002132_abnormal_respiratory_system0.75201103
109MP0000858_altered_metastatic_potential0.75163671
110MP0001286_abnormal_eye_development0.73963515
111MP0000653_abnormal_sex_gland0.73682973
112MP0003221_abnormal_cardiomyocyte_apopto0.73655076
113MP0005395_other_phenotype0.72697620
114MP0009278_abnormal_bone_marrow0.71960282
115MP0000383_abnormal_hair_follicle0.71803118
116MP0000427_abnormal_hair_cycle0.70746227
117MP0002751_abnormal_autonomic_nervous0.70743344
118MP0008872_abnormal_physiological_respon0.70488172
119MP0002282_abnormal_trachea_morphology0.69257880
120MP0003656_abnormal_erythrocyte_physiolo0.68771000
121MP0001929_abnormal_gametogenesis0.67264509
122MP0004147_increased_porphyrin_level0.66456048
123MP0005621_abnormal_cell_physiology0.65364887
124MP0000477_abnormal_intestine_morphology0.65220070
125MP0003698_abnormal_male_reproductive0.64305229
126MP0005389_reproductive_system_phenotype0.64056930
127MP0003861_abnormal_nervous_system0.63887977
128MP0008873_increased_physiological_sensi0.62598101
129MP0001119_abnormal_female_reproductive0.62375336
130MP0005266_abnormal_metabolism0.62051074
131MP0001853_heart_inflammation0.61778767
132MP0002932_abnormal_joint_morphology0.61512938
133MP0003942_abnormal_urinary_system0.60441430
134MP0000716_abnormal_immune_system0.59689570
135MP0003186_abnormal_redox_activity0.57908554
136MP0005023_abnormal_wound_healing0.57458847
137MP0009703_decreased_birth_body0.57335721
138MP0003941_abnormal_skin_development0.56949266
139MP0001849_ear_inflammation0.56514663
140MP0008770_decreased_survivor_rate0.56170424
141MP0002697_abnormal_eye_size0.55681979
142MP0002114_abnormal_axial_skeleton0.54810154
143MP0003115_abnormal_respiratory_system0.53279584

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.73420425
2Reticulocytopenia (HP:0001896)4.68196090
3Abnormality of cells of the erythroid lineage (HP:0012130)4.62851362
4Abnormal number of erythroid precursors (HP:0012131)4.37132128
5Colon cancer (HP:0003003)3.81695357
6Breast hypoplasia (HP:0003187)3.66263741
7Selective tooth agenesis (HP:0001592)3.58355747
8Oral leukoplakia (HP:0002745)3.47881628
9Medulloblastoma (HP:0002885)3.43805377
10Patellar aplasia (HP:0006443)3.43259590
11Aplasia/Hypoplasia of the patella (HP:0006498)3.22175436
12Degeneration of anterior horn cells (HP:0002398)3.16649802
13Abnormality of the anterior horn cell (HP:0006802)3.16649802
14Aplastic anemia (HP:0001915)3.16263604
15Chromsome breakage (HP:0040012)3.15815556
16Abnormal number of incisors (HP:0011064)3.10264122
17Abnormality of alanine metabolism (HP:0010916)3.09516417
18Hyperalaninemia (HP:0003348)3.09516417
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.09516417
20Ependymoma (HP:0002888)3.09132347
21Macrocytic anemia (HP:0001972)3.02032704
22Pallor (HP:0000980)2.99346206
23Meckel diverticulum (HP:0002245)2.96947387
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95062187
25Abnormality of the ileum (HP:0001549)2.88724973
26Abnormality of chromosome stability (HP:0003220)2.81086680
27Agnosia (HP:0010524)2.80980334
28Rough bone trabeculation (HP:0100670)2.76454736
29Absent thumb (HP:0009777)2.75556058
30Abnormality of the preputium (HP:0100587)2.74544510
3111 pairs of ribs (HP:0000878)2.67929908
32Carpal bone hypoplasia (HP:0001498)2.60442968
33Neoplasm of the pancreas (HP:0002894)2.59852712
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.58291262
35Abnormality of serum amino acid levels (HP:0003112)2.55325375
36Small intestinal stenosis (HP:0012848)2.54344474
37Duodenal stenosis (HP:0100867)2.54344474
38Myelodysplasia (HP:0002863)2.54272699
39Absent radius (HP:0003974)2.52190834
40Abnormal lung lobation (HP:0002101)2.51281918
41Atresia of the external auditory canal (HP:0000413)2.51002376
42Stenosis of the external auditory canal (HP:0000402)2.47298712
43Cerebral hypomyelination (HP:0006808)2.47006063
44Trismus (HP:0000211)2.46692345
45Rhabdomyosarcoma (HP:0002859)2.45885905
46Premature graying of hair (HP:0002216)2.43281201
47Microretrognathia (HP:0000308)2.40165886
48Hyperglycinemia (HP:0002154)2.40033193
49Multiple enchondromatosis (HP:0005701)2.40022904
50Absent forearm bone (HP:0003953)2.35410437
51Aplasia involving forearm bones (HP:0009822)2.35410437
52Proximal placement of thumb (HP:0009623)2.34801565
53Intestinal atresia (HP:0011100)2.34578898
54Abnormality of the labia minora (HP:0012880)2.34367615
55Glossoptosis (HP:0000162)2.28790728
56Horseshoe kidney (HP:0000085)2.26031487
57Abnormality of the septum pellucidum (HP:0007375)2.25621125
58Abnormality of methionine metabolism (HP:0010901)2.24399956
59Tracheoesophageal fistula (HP:0002575)2.24188136
60Deviation of the thumb (HP:0009603)2.23953389
61Increased nuchal translucency (HP:0010880)2.23826128
62Basal cell carcinoma (HP:0002671)2.23618636
63Triphalangeal thumb (HP:0001199)2.21685109
64Papillary thyroid carcinoma (HP:0002895)2.20471769
65Bone marrow hypocellularity (HP:0005528)2.19943817
66Supernumerary spleens (HP:0009799)2.19076363
67Aplasia/Hypoplasia of the sternum (HP:0006714)2.16326294
68Thrombocytosis (HP:0001894)2.16248348
69Cleft eyelid (HP:0000625)2.15915831
70Pancreatic cysts (HP:0001737)2.15193036
71Abnormality of the duodenum (HP:0002246)2.14203354
72Hypoplastic labia majora (HP:0000059)2.11349686
73Septo-optic dysplasia (HP:0100842)2.09951211
74Biliary tract neoplasm (HP:0100574)2.09840342
75Cellular immunodeficiency (HP:0005374)2.09123618
76Sloping forehead (HP:0000340)2.08371303
77Missing ribs (HP:0000921)2.06425354
78Median cleft lip (HP:0000161)2.04827535
79Ectopic kidney (HP:0000086)2.02742822
80Abnormality of the pons (HP:0007361)2.02546413
81Bifid tongue (HP:0010297)1.99920160
82Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99701969
83Slender long bone (HP:0003100)1.98076443
84Short 4th metacarpal (HP:0010044)1.97568213
85Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97568213
86Cortical dysplasia (HP:0002539)1.96129194
87Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95972631
88Impulsivity (HP:0100710)1.95435856
89Atrophy/Degeneration involving motor neurons (HP:0007373)1.93314291
90Neoplasm of the small intestine (HP:0100833)1.92441782
91Pancreatic fibrosis (HP:0100732)1.92297148
92Abnormality of abdominal situs (HP:0011620)1.92192071
93Abdominal situs inversus (HP:0003363)1.92192071
94Amyotrophic lateral sclerosis (HP:0007354)1.92162728
95Lymphoma (HP:0002665)1.91918467
96Absent septum pellucidum (HP:0001331)1.91072634
97Clubbing of toes (HP:0100760)1.90817465
98Optic nerve coloboma (HP:0000588)1.90189662
99Squamous cell carcinoma (HP:0002860)1.89920872
100Neoplasm of the colon (HP:0100273)1.89705939
101Gastrointestinal atresia (HP:0002589)1.88968392
102Abnormality of midbrain morphology (HP:0002418)1.88243277
103Molar tooth sign on MRI (HP:0002419)1.88243277
104Nephroblastoma (Wilms tumor) (HP:0002667)1.87851883
105Abnormal trabecular bone morphology (HP:0100671)1.87797202
106Stomach cancer (HP:0012126)1.87747519
107Thyroid carcinoma (HP:0002890)1.86199753
108Hypoplasia of the radius (HP:0002984)1.84925647
109Neoplasm of striated muscle (HP:0009728)1.84110802
110Abnormality of the astrocytes (HP:0100707)1.84015067
111Astrocytoma (HP:0009592)1.84015067
112Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83886786
113Short thumb (HP:0009778)1.83473093
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82984426
115Abnormality of the labia majora (HP:0012881)1.82750857
116Amaurosis fugax (HP:0100576)1.82430454
117Abnormality of the carotid arteries (HP:0005344)1.81824279
118Abnormality of reticulocytes (HP:0004312)1.81810147
119Facial cleft (HP:0002006)1.80218803
120Medial flaring of the eyebrow (HP:0010747)1.79783167
121Cupped ear (HP:0000378)1.79648945
122Glioma (HP:0009733)1.79306528
123Increased hepatocellular lipid droplets (HP:0006565)1.79094784
124Methylmalonic acidemia (HP:0002912)1.78660061
125Hypoplasia of the pons (HP:0012110)1.76910208
126Embryonal renal neoplasm (HP:0011794)1.75855418
127Homocystinuria (HP:0002156)1.75371368
128Abnormality of homocysteine metabolism (HP:0010919)1.75371368
129Abnormality of DNA repair (HP:0003254)1.75079590
130Pancytopenia (HP:0001876)1.73228510
131Duplicated collecting system (HP:0000081)1.73017825
132Preauricular skin tag (HP:0000384)1.72801277
133Cafe-au-lait spot (HP:0000957)1.72562460
134Volvulus (HP:0002580)1.72084906
135Abnormality of glycolysis (HP:0004366)1.71696204
136Increased serum pyruvate (HP:0003542)1.71696204
137Premature ovarian failure (HP:0008209)1.70960493
138Gonadotropin excess (HP:0000837)1.70510028
139Dyskinesia (HP:0100660)1.70110321
140Neoplasm of the oral cavity (HP:0100649)1.70062119
141Abolished electroretinogram (ERG) (HP:0000550)1.67882032
142Fair hair (HP:0002286)1.67666906
143Acute necrotizing encephalopathy (HP:0006965)1.67595314
144Limb hypertonia (HP:0002509)1.67057214
145Progressive inability to walk (HP:0002505)1.66718511
146Chronic hepatic failure (HP:0100626)1.66265876
147Renal cortical cysts (HP:0000803)1.65048343
148Lipid accumulation in hepatocytes (HP:0006561)1.64729433
149Postnatal microcephaly (HP:0005484)1.64098316
150Cerebral edema (HP:0002181)1.62692729
151Acute encephalopathy (HP:0006846)1.61417427
152Nephrogenic diabetes insipidus (HP:0009806)1.60857444
153Hyperglycinuria (HP:0003108)1.60444635
154True hermaphroditism (HP:0010459)1.60435182
155Abnormal hair whorl (HP:0010721)1.58265726
156IgM deficiency (HP:0002850)1.57750863
157Increased serum lactate (HP:0002151)1.57090540
158Hypothermia (HP:0002045)1.57059864
159Genital tract atresia (HP:0001827)1.56794288
160Small hand (HP:0200055)1.56756163
161Ovarian neoplasm (HP:0100615)1.56283132
162Progressive macrocephaly (HP:0004481)1.55876252
163Increased CSF lactate (HP:0002490)1.54357937
164Astigmatism (HP:0000483)1.53785692
165Oligodactyly (hands) (HP:0001180)1.53112633
166Labial hypoplasia (HP:0000066)1.52704246

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.57806653
2BUB14.55467706
3WEE14.24214452
4EIF2AK12.97105843
5BMPR1B2.77049906
6TSSK62.61548851
7SRPK12.53762535
8NEK22.48357598
9NUAK12.42690783
10TRIM282.41292350
11TNIK2.25773478
12TTK2.22712582
13STK162.20093782
14NEK12.19717775
15PASK2.14885106
16MKNK12.10077441
17NME22.08837052
18ACVR1B2.00139503
19TESK21.96626621
20BRSK21.93623486
21PLK11.89765310
22TAF11.89704793
23EIF2AK31.86238791
24CDK71.85103342
25DYRK31.84942992
26RPS6KB21.83347913
27ATR1.80611152
28VRK11.76119197
29PLK41.73644107
30MAP4K21.71501050
31TGFBR11.69209649
32EEF2K1.68199941
33TLK11.65828042
34AURKB1.65553144
35RPS6KA41.63812710
36BCR1.58273491
37PDK21.57399504
38MAP3K41.56950385
39PLK31.52969544
40MAP3K101.50769306
41SCYL21.43502793
42CDK41.40548417
43BRSK11.37490477
44ERBB31.36744975
45PAK41.35463627
46MAP3K81.35353252
47MKNK21.32862359
48CHEK21.30327709
49AURKA1.29309048
50WNK31.23646902
51CHEK11.23632666
52CDK121.19321490
53CCNB11.14412347
54NLK1.12475031
55STK101.10667298
56FRK1.07259686
57LATS11.03857667
58SIK31.01184697
59CDK80.98074281
60CSNK1G10.95204998
61STK40.90402750
62PKN20.89372675
63PIM20.86873255
64CDK20.86000331
65TESK10.85355917
66VRK20.83926714
67EPHA20.82836561
68TAOK30.82524292
69ATM0.82323929
70OXSR10.80366129
71STK38L0.79750821
72LRRK20.78237275
73CSNK2A20.77626294
74CLK10.75076368
75PIM10.74544721
76ALK0.72395380
77BRD40.72220881
78KDR0.71716730
79TAOK20.71677442
80CSNK2A10.71372517
81CDK60.71343295
82MAP4K10.71093567
83CASK0.70057783
84FLT30.70017579
85CSNK1G20.69251139
86PAK10.69137326
87PLK20.67808150
88IRAK10.67695160
89MAP2K70.67439339
90STK240.67019204
91MAP3K110.65372461
92CDK10.63640876
93MAPK130.62496811
94EIF2AK20.62151839
95BRAF0.54152672
96ILK0.53395689
97MAPKAPK30.52715643
98STK390.52077210
99MELK0.51891405
100MARK30.51838046
101ZAK0.51687017
102AKT20.51168930
103SGK20.51164501
104PNCK0.47904289
105PRKCI0.47713318
106RPS6KA50.46357525
107MAP2K30.46308162
108ERBB40.45003605
109DYRK20.44956343
110DAPK10.43501106
111PBK0.42574494
112BTK0.41672913
113NEK60.40970484
114TEC0.40588239
115PIK3CG0.39851812
116LIMK10.39294913
117YES10.38809845
118CSNK1E0.36404965
119GRK60.36311030
120MAP3K50.35277206
121CDK30.35052956
122MINK10.33902107
123PAK20.33308070
124INSRR0.33206040
125PRKDC0.32278477
126FGFR10.31892510
127MAP3K120.30590585
128PRKCE0.30550724
129CAMKK20.30329258
130NTRK20.30073508
131CSNK1D0.29746184
132GRK10.29722423
133CDK90.28569662
134CSNK1G30.27692782
135MST40.25709550
136MTOR0.25671367
137CDK11A0.25291635
138STK30.25090086
139NME10.24603049
140ZAP700.23042431
141CDK190.22413580
142CSF1R0.22339912
143CDK180.21470755
144MAPKAPK20.21223851
145UHMK10.20503964

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.37455053
2Mismatch repair_Homo sapiens_hsa034304.50684078
3Ribosome_Homo sapiens_hsa030103.82921964
4* Spliceosome_Homo sapiens_hsa030403.58933132
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.43532880
6Proteasome_Homo sapiens_hsa030503.40340021
7Base excision repair_Homo sapiens_hsa034103.22437210
8RNA transport_Homo sapiens_hsa030133.13680358
9RNA polymerase_Homo sapiens_hsa030203.09254057
10Homologous recombination_Homo sapiens_hsa034402.99092613
11Nucleotide excision repair_Homo sapiens_hsa034202.98273951
12Cell cycle_Homo sapiens_hsa041102.79864883
13One carbon pool by folate_Homo sapiens_hsa006702.55643647
14Pyrimidine metabolism_Homo sapiens_hsa002402.51193877
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48234304
16Fanconi anemia pathway_Homo sapiens_hsa034602.10581121
17Non-homologous end-joining_Homo sapiens_hsa034502.10472791
18RNA degradation_Homo sapiens_hsa030181.86701526
19Propanoate metabolism_Homo sapiens_hsa006401.86150312
20mRNA surveillance pathway_Homo sapiens_hsa030151.79214399
21Basal transcription factors_Homo sapiens_hsa030221.73198943
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72482030
23Steroid biosynthesis_Homo sapiens_hsa001001.58201233
24p53 signaling pathway_Homo sapiens_hsa041151.54628610
25Purine metabolism_Homo sapiens_hsa002301.29205565
26Epstein-Barr virus infection_Homo sapiens_hsa051691.24419956
27Systemic lupus erythematosus_Homo sapiens_hsa053221.14112189
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09656164
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07325333
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00086734
31Viral carcinogenesis_Homo sapiens_hsa052030.94606294
32Oocyte meiosis_Homo sapiens_hsa041140.93736852
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93643255
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92342383
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91976038
36Herpes simplex infection_Homo sapiens_hsa051680.88361792
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88050429
38Antigen processing and presentation_Homo sapiens_hsa046120.84380697
39Circadian rhythm_Homo sapiens_hsa047100.83854161
40HTLV-I infection_Homo sapiens_hsa051660.82806680
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82401482
42Biosynthesis of amino acids_Homo sapiens_hsa012300.81506123
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.81127697
44Nitrogen metabolism_Homo sapiens_hsa009100.79574143
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74332272
46Pentose phosphate pathway_Homo sapiens_hsa000300.72151480
47Thyroid cancer_Homo sapiens_hsa052160.71460992
48Pyruvate metabolism_Homo sapiens_hsa006200.71413009
49Regulation of autophagy_Homo sapiens_hsa041400.67731518
50Butanoate metabolism_Homo sapiens_hsa006500.65823934
51Basal cell carcinoma_Homo sapiens_hsa052170.64858990
52Protein export_Homo sapiens_hsa030600.64128080
53Legionellosis_Homo sapiens_hsa051340.63190186
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.61491007
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60020088
56MicroRNAs in cancer_Homo sapiens_hsa052060.59758031
57Huntingtons disease_Homo sapiens_hsa050160.59714345
58Small cell lung cancer_Homo sapiens_hsa052220.58856331
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57432191
60Selenocompound metabolism_Homo sapiens_hsa004500.56979443
61Nicotine addiction_Homo sapiens_hsa050330.56141546
62Sulfur relay system_Homo sapiens_hsa041220.55348602
63Folate biosynthesis_Homo sapiens_hsa007900.55118151
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53922105
65Hippo signaling pathway_Homo sapiens_hsa043900.52441343
66Primary immunodeficiency_Homo sapiens_hsa053400.52349011
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51397217
68N-Glycan biosynthesis_Homo sapiens_hsa005100.51333626
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.50568083
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50126233
71Parkinsons disease_Homo sapiens_hsa050120.49582561
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49374566
73Colorectal cancer_Homo sapiens_hsa052100.49007343
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48363922
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48038143
76Alcoholism_Homo sapiens_hsa050340.46640912
77Alzheimers disease_Homo sapiens_hsa050100.46458817
78TGF-beta signaling pathway_Homo sapiens_hsa043500.45249181
79Collecting duct acid secretion_Homo sapiens_hsa049660.42948442
80Carbon metabolism_Homo sapiens_hsa012000.41573607
81Apoptosis_Homo sapiens_hsa042100.41338140
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40981272
83Asthma_Homo sapiens_hsa053100.40975727
84Shigellosis_Homo sapiens_hsa051310.40495799
85Chronic myeloid leukemia_Homo sapiens_hsa052200.39866386
86Hedgehog signaling pathway_Homo sapiens_hsa043400.39773752
87Glutathione metabolism_Homo sapiens_hsa004800.39487682
88Fatty acid elongation_Homo sapiens_hsa000620.38685849
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38284173
90Hepatitis B_Homo sapiens_hsa051610.37499912
91Peroxisome_Homo sapiens_hsa041460.37074870
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.37045767
93Notch signaling pathway_Homo sapiens_hsa043300.36595673
94Bladder cancer_Homo sapiens_hsa052190.36430332
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35338860
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34505831
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32637631
98Measles_Homo sapiens_hsa051620.31772625
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31353176
100Pathways in cancer_Homo sapiens_hsa052000.29703549
101Viral myocarditis_Homo sapiens_hsa054160.28027452
102HIF-1 signaling pathway_Homo sapiens_hsa040660.26747112
103Phototransduction_Homo sapiens_hsa047440.26701466
104Olfactory transduction_Homo sapiens_hsa047400.25468092
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.24970657
106Tryptophan metabolism_Homo sapiens_hsa003800.24315796
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23862377
108Taste transduction_Homo sapiens_hsa047420.23854506
109Retinol metabolism_Homo sapiens_hsa008300.23302324
110Linoleic acid metabolism_Homo sapiens_hsa005910.21596218
111Type I diabetes mellitus_Homo sapiens_hsa049400.21053602
112beta-Alanine metabolism_Homo sapiens_hsa004100.19783478
113Wnt signaling pathway_Homo sapiens_hsa043100.19775690
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.17318468
115Oxidative phosphorylation_Homo sapiens_hsa001900.17243541
116Fructose and mannose metabolism_Homo sapiens_hsa000510.17092961
117Acute myeloid leukemia_Homo sapiens_hsa052210.17009361
118Non-small cell lung cancer_Homo sapiens_hsa052230.16847550
119Ether lipid metabolism_Homo sapiens_hsa005650.16280529
120Fatty acid biosynthesis_Homo sapiens_hsa000610.16261034
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16229163
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15813200
123Galactose metabolism_Homo sapiens_hsa000520.14915013
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13852814
125Renin-angiotensin system_Homo sapiens_hsa046140.13068268
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.13009267
127Hematopoietic cell lineage_Homo sapiens_hsa046400.12978695
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12919937
129Influenza A_Homo sapiens_hsa051640.12217751
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.12145882
131Metabolic pathways_Homo sapiens_hsa011000.11848506
132Prostate cancer_Homo sapiens_hsa052150.11578655
133Adherens junction_Homo sapiens_hsa045200.10891016
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07997151
135Melanoma_Homo sapiens_hsa052180.07735456
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07654253
137Pancreatic cancer_Homo sapiens_hsa052120.07182771
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.07065413
139mTOR signaling pathway_Homo sapiens_hsa041500.06892256

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