RBMXL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)9.87893824
2meiotic nuclear division (GO:0007126)8.60366826
3meiosis I (GO:0007127)8.50181211
4regulation of meiosis I (GO:0060631)8.21638514
5DNA synthesis involved in DNA repair (GO:0000731)7.79141472
6regulation of posttranscriptional gene silencing (GO:0060147)6.56983140
7regulation of gene silencing by miRNA (GO:0060964)6.56983140
8regulation of gene silencing by RNA (GO:0060966)6.56983140
9meiotic cell cycle process (GO:1903046)6.45741490
10sister chromatid cohesion (GO:0007062)6.11739412
11spermatid development (GO:0007286)6.11317702
12acrosome reaction (GO:0007340)6.10186587
13resolution of meiotic recombination intermediates (GO:0000712)6.09883191
14positive regulation of meiosis (GO:0045836)6.01906560
15fusion of sperm to egg plasma membrane (GO:0007342)5.75576509
16positive regulation of meiotic cell cycle (GO:0051446)5.72901416
17sperm motility (GO:0030317)5.65350533
18negative regulation of inclusion body assembly (GO:0090084)5.45009885
19histone H3-K9 demethylation (GO:0033169)5.13772637
20DNA replication-dependent nucleosome organization (GO:0034723)5.12084708
21DNA replication-dependent nucleosome assembly (GO:0006335)5.12084708
22binding of sperm to zona pellucida (GO:0007339)5.11464185
23nuclear pore organization (GO:0006999)4.97710962
24nuclear pore complex assembly (GO:0051292)4.82161672
25germ cell development (GO:0007281)4.69383734
26heterochromatin organization (GO:0070828)4.60514689
27histone H3-K36 demethylation (GO:0070544)4.56328854
28DNA packaging (GO:0006323)4.55851498
29somatic hypermutation of immunoglobulin genes (GO:0016446)4.55160455
30somatic diversification of immune receptors via somatic mutation (GO:0002566)4.55160455
31plasma membrane fusion (GO:0045026)4.46968082
32sperm-egg recognition (GO:0035036)4.44415956
33regulation of histone H3-K9 methylation (GO:0051570)4.43459556
34establishment of apical/basal cell polarity (GO:0035089)4.41973052
35histone H4-K12 acetylation (GO:0043983)4.38399415
36mitotic sister chromatid cohesion (GO:0007064)4.36663092
37reciprocal meiotic recombination (GO:0007131)4.31084730
38reciprocal DNA recombination (GO:0035825)4.31084730
39DNA methylation (GO:0006306)4.28951960
40DNA alkylation (GO:0006305)4.28951960
41regulation of cilium movement (GO:0003352)4.25400173
42meiotic cell cycle (GO:0051321)4.18035750
43pre-miRNA processing (GO:0031054)4.13707525
44protein localization to kinetochore (GO:0034501)4.13038470
45male gamete generation (GO:0048232)4.09560657
46spermatogenesis (GO:0007283)4.09536238
47regulation of helicase activity (GO:0051095)4.02378285
48mitotic sister chromatid segregation (GO:0000070)4.01059114
49determination of adult lifespan (GO:0008340)4.00622497
50DNA replication initiation (GO:0006270)3.96522123
51chromatin assembly (GO:0031497)3.94026977
52female gamete generation (GO:0007292)3.93223246
53cellular process involved in reproduction in multicellular organism (GO:0022412)3.91866665
54gamete generation (GO:0007276)3.91720725
55folic acid-containing compound biosynthetic process (GO:0009396)3.87374894
56gene silencing (GO:0016458)3.87173424
57paraxial mesoderm development (GO:0048339)3.84736730
58protein localization to chromosome, centromeric region (GO:0071459)3.83719206
59regulation of gene silencing (GO:0060968)3.80495803
60regulation of translational fidelity (GO:0006450)3.79103566
61regulation of meiotic cell cycle (GO:0051445)3.78925370
62mitotic nuclear envelope disassembly (GO:0007077)3.77384069
63regulation of DNA endoreduplication (GO:0032875)3.77061615
64histone exchange (GO:0043486)3.76484798
65establishment of monopolar cell polarity (GO:0061162)3.76476034
66establishment or maintenance of monopolar cell polarity (GO:0061339)3.76476034
67formation of translation preinitiation complex (GO:0001731)3.75069420
68DNA unwinding involved in DNA replication (GO:0006268)3.74339748
69fertilization (GO:0009566)3.72797214
70pore complex assembly (GO:0046931)3.58259136
71anterior/posterior axis specification, embryo (GO:0008595)3.58089981
72oogenesis (GO:0048477)3.57428931
73cell-cell recognition (GO:0009988)3.57317887
74positive regulation of SMAD protein import into nucleus (GO:0060391)3.57198779
75ribosome biogenesis (GO:0042254)3.52355261
76histone arginine methylation (GO:0034969)3.51666278
77mitotic metaphase plate congression (GO:0007080)3.51340168
78nuclear envelope disassembly (GO:0051081)3.51076031
79membrane disassembly (GO:0030397)3.51076031
80protein K6-linked ubiquitination (GO:0085020)3.48389497
81regulation of nuclear cell cycle DNA replication (GO:0033262)3.48014473
82regulation of hippo signaling (GO:0035330)3.46298940
83motile cilium assembly (GO:0044458)3.46026124
84DNA geometric change (GO:0032392)3.45430542
85negative regulation of histone methylation (GO:0031061)3.44917711
86DNA duplex unwinding (GO:0032508)3.44827519
87histone H4-K8 acetylation (GO:0043982)3.44659867
88histone H4-K5 acetylation (GO:0043981)3.44659867
89single strand break repair (GO:0000012)3.44117254
90sister chromatid segregation (GO:0000819)3.43524797
91genitalia morphogenesis (GO:0035112)3.40421745
92DNA strand elongation involved in DNA replication (GO:0006271)3.39436333
93nucleobase biosynthetic process (GO:0046112)3.38884174
94regulation of microtubule-based movement (GO:0060632)3.38288092
95regulation of meiosis (GO:0040020)3.36825476
96protein K11-linked deubiquitination (GO:0035871)3.36468398
97DNA replication checkpoint (GO:0000076)3.36420134
98regulation of telomere maintenance via telomerase (GO:0032210)3.35589012
99maturation of SSU-rRNA (GO:0030490)3.33381092
100centriole replication (GO:0007099)3.31294115
101regulation of inclusion body assembly (GO:0090083)3.30081558
102centriole assembly (GO:0098534)3.28974145
103IMP biosynthetic process (GO:0006188)3.26583586
104axonemal dynein complex assembly (GO:0070286)3.23344505
105embryonic process involved in female pregnancy (GO:0060136)3.22819785
106DNA strand elongation (GO:0022616)3.19214938
107piRNA metabolic process (GO:0034587)3.17331523
108maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.15514113
109histone H2A acetylation (GO:0043968)3.14630767
110negative regulation of gene silencing (GO:0060969)3.14038751
111chromosome organization (GO:0051276)3.13922290
112spliceosomal tri-snRNP complex assembly (GO:0000244)3.13437403
113ribonucleoprotein complex biogenesis (GO:0022613)3.13325913
114polarized epithelial cell differentiation (GO:0030859)3.13010655
115positive regulation of chromosome segregation (GO:0051984)3.12511755
116ribosomal small subunit biogenesis (GO:0042274)3.12063203
117replication fork processing (GO:0031297)3.12045570
118sex differentiation (GO:0007548)3.11701344
119negative regulation of meiosis (GO:0045835)3.11609881
120calcium ion-dependent exocytosis (GO:0017156)3.09953017
121telomere maintenance via semi-conservative replication (GO:0032201)3.08941695
122DNA catabolic process, exonucleolytic (GO:0000738)3.08712536
123sperm capacitation (GO:0048240)3.08619868
124meiotic chromosome segregation (GO:0045132)3.07354444
125synaptonemal complex assembly (GO:0007130)3.07346576
126multicellular organismal reproductive process (GO:0048609)3.06912397
127negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.05479084
128embryonic body morphogenesis (GO:0010172)3.05229870
129trophectodermal cell differentiation (GO:0001829)3.03427531
130metaphase plate congression (GO:0051310)3.01671662
131regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00822287
132spermatid nucleus differentiation (GO:0007289)3.00118710
133DNA methylation or demethylation (GO:0044728)2.99702833
134kinetochore organization (GO:0051383)2.99377260
135nodal signaling pathway (GO:0038092)2.98950842
136histone lysine demethylation (GO:0070076)2.97856295
137purine nucleobase biosynthetic process (GO:0009113)2.94253999
138mitotic chromosome condensation (GO:0007076)2.94081364
139DNA conformation change (GO:0071103)2.93077148
140histone demethylation (GO:0016577)2.92080687
141chromatin assembly or disassembly (GO:0006333)2.91819688
142positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91437884
143positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91437884
144positive regulation of mitotic sister chromatid separation (GO:1901970)2.91437884
145peptidyl-arginine omega-N-methylation (GO:0035247)2.91208460
146chromatin remodeling at centromere (GO:0031055)2.90778802
147chaperone-mediated protein complex assembly (GO:0051131)2.90422093
148kinetochore assembly (GO:0051382)2.90171361
149regulation of centriole replication (GO:0046599)2.89907311
150nuclear division (GO:0000280)2.89742142
151regulation of double-strand break repair (GO:2000779)2.89617487
152mitochondrial DNA metabolic process (GO:0032042)2.89600426
153regulation of SMAD protein import into nucleus (GO:0060390)2.88460240
154apoptotic process involved in morphogenesis (GO:0060561)2.88407741
155cilium or flagellum-dependent cell motility (GO:0001539)2.87686755
156interkinetic nuclear migration (GO:0022027)2.86399209
157regulation of sister chromatid cohesion (GO:0007063)2.85489164
158synaptonemal complex organization (GO:0070193)2.85410875
159spindle assembly (GO:0051225)2.84994651
160microtubule depolymerization (GO:0007019)2.82431020
161negative regulation of androgen receptor signaling pathway (GO:0060766)2.81317858
162regulation of centrosome cycle (GO:0046605)2.80992899
163proline biosynthetic process (GO:0006561)2.80432336
164IMP metabolic process (GO:0046040)2.78715957
165gene silencing by RNA (GO:0031047)2.77833688
166microtubule polymerization or depolymerization (GO:0031109)2.77309293
167chromosome condensation (GO:0030261)2.77105637
168DNA biosynthetic process (GO:0071897)2.77058015
169regulation of double-strand break repair via homologous recombination (GO:0010569)2.76702473
170nonmotile primary cilium assembly (GO:0035058)2.75754608
171mRNA transport (GO:0051028)2.75144767
172protein polyglutamylation (GO:0018095)2.74558738
173epithelial cilium movement (GO:0003351)2.73915026
174organelle fission (GO:0048285)2.73237956
175histone H4-K16 acetylation (GO:0043984)2.73134723
176rRNA methylation (GO:0031167)2.72983240
177phosphatidylethanolamine biosynthetic process (GO:0006646)2.72151554
178multicellular organism reproduction (GO:0032504)2.71749324
179attachment of spindle microtubules to kinetochore (GO:0008608)2.69244501
180protein dealkylation (GO:0008214)2.64143083
181protein demethylation (GO:0006482)2.64143083
182synapsis (GO:0007129)13.4106702
183male meiosis (GO:0007140)11.0352380
184male meiosis I (GO:0007141)10.7313237
185chromosome organization involved in meiosis (GO:0070192)10.2798295

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.15605832
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.33958183
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.33958183
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.33958183
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.63674276
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.61339511
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.56900556
8IGF1R_20145208_ChIP-Seq_DFB_Human3.50632075
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.07157158
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04235575
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.97468137
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90294170
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.80398925
14FUS_26573619_Chip-Seq_HEK293_Human2.53503608
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.51782558
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.48785434
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48252037
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46798232
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.38170676
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.34809222
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.31831046
22STAT3_1855785_ChIP-Seq_MESCs_Mouse2.31574529
23SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.29727566
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29465447
25ZNF274_21170338_ChIP-Seq_K562_Hela2.29183947
26TCF3_18692474_ChIP-Seq_MESCs_Mouse2.25925507
27VDR_22108803_ChIP-Seq_LS180_Human2.23047050
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21164579
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20577964
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.20346728
31SOX2_18555785_ChIP-Seq_MESCs_Mouse2.16816586
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12408137
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.11473172
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.11251034
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.09068620
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08637842
37RNF2_27304074_Chip-Seq_NSC_Mouse2.08330175
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04729820
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02673271
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96035262
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.93393480
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92773596
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.89066740
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.88799006
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86556920
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.85255098
47BCAT_22108803_ChIP-Seq_LS180_Human1.84489646
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82418569
49NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.77834023
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.75592917
51POU5F1_16518401_ChIP-PET_MESCs_Mouse1.70459044
52ERA_21632823_ChIP-Seq_H3396_Human1.68897772
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67805256
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67805256
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66753897
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.65961525
57ER_23166858_ChIP-Seq_MCF-7_Human1.65781741
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65608725
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63517144
60NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.62934283
61XRN2_22483619_ChIP-Seq_HELA_Human1.61065557
62SMAD4_21741376_ChIP-Seq_EPCs_Human1.60385447
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60138806
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.56960894
65SOX2_18692474_ChIP-Seq_MESCs_Mouse1.55101471
66AR_25329375_ChIP-Seq_VCAP_Human1.51779342
67RUNX2_22187159_ChIP-Seq_PCA_Human1.50818099
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.49401456
69SOX2_18692474_ChIP-Seq_MEFs_Mouse1.48956456
70NANOG_18692474_ChIP-Seq_MEFs_Mouse1.45636091
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45394624
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.44581340
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.44339192
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43581726
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43082204
76NANOG_18692474_ChIP-Seq_MESCs_Mouse1.42292850
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41676454
78TAF15_26573619_Chip-Seq_HEK293_Human1.41009927
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.40511557
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40316555
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39310513
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38854635
83POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.37540491
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.36429766
85TP53_22573176_ChIP-Seq_HFKS_Human1.35526049
86MYC_19829295_ChIP-Seq_ESCs_Human1.34690975
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34074513
88STAT3_23295773_ChIP-Seq_U87_Human1.33358720
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32947751
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32653156
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32200946
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31212634
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.30667882
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29904853
95GATA3_26560356_Chip-Seq_TH1_Human1.29650030
96* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29254292
97P300_19829295_ChIP-Seq_ESCs_Human1.28476339
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28260292
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27495337
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.27342992
101RAC3_21632823_ChIP-Seq_H3396_Human1.25657313
102TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.25436402
103YY1_22570637_ChIP-Seq_MALME-3M_Human1.24738448
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24191300
105SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.23799796
106HOXB7_26014856_ChIP-Seq_BT474_Human1.23306836
107GBX2_23144817_ChIP-Seq_PC3_Human1.22815358
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22278096
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22071176
110FOXH1_21741376_ChIP-Seq_EPCs_Human1.21922182
111THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21846305
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.21208562
113AR_21909140_ChIP-Seq_LNCAP_Human1.21009225
114WDR5_24793694_ChIP-Seq_LNCAP_Human1.19310552
115TCF4_23295773_ChIP-Seq_U87_Human1.18736609
116TTF2_22483619_ChIP-Seq_HELA_Human1.17971366
117OCT4_20526341_ChIP-Seq_ESCs_Human1.16725486
118EGR1_19374776_ChIP-ChIP_THP-1_Human1.15307254
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15287406
120* KAP1_27257070_Chip-Seq_ESCs_Mouse1.14608105
121ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12207611
122PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.11336142
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11073709
124VDR_23849224_ChIP-Seq_CD4+_Human1.10518251
125KDM5A_27292631_Chip-Seq_BREAST_Human1.07802283
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07032816
127ETV1_20927104_ChIP-Seq_GIST48_Human1.06576646
128NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06419708
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05891785
130DCP1A_22483619_ChIP-Seq_HELA_Human1.05793972
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05541790
132CBP_20019798_ChIP-Seq_JUKART_Human1.05541790
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05054981
134FOXP3_21729870_ChIP-Seq_TREG_Human1.04472741
135POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03762221
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02971673
137MYC_22102868_ChIP-Seq_BL_Human1.02708786
138GABP_19822575_ChIP-Seq_HepG2_Human1.02521361
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01693724
140RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01607555
141NANOG_16518401_ChIP-PET_MESCs_Mouse1.01052729
142SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00576388
143SMAD4_21799915_ChIP-Seq_A2780_Human1.00527332
144CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00185243
145E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00161570
146ZNF263_19887448_ChIP-Seq_K562_Human0.99778452
147GABP_17652178_ChIP-ChIP_JURKAT_Human0.99691650
148TP63_19390658_ChIP-ChIP_HaCaT_Human0.99467612
149CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99115721
150RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99084315
151MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98991278
152SMC4_20622854_ChIP-Seq_HELA_Human0.98981478
153BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.98914209
154CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98856873
155CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98809739
156PHF8_20622854_ChIP-Seq_HELA_Human0.98684339
157SOX9_26525672_Chip-Seq_HEART_Mouse0.98215963
158TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97726683
159SOX2_19829295_ChIP-Seq_ESCs_Human0.97560192
160NANOG_19829295_ChIP-Seq_ESCs_Human0.97560192
161SMAD3_21741376_ChIP-Seq_ESCs_Human0.97555562
162MYC_18940864_ChIP-ChIP_HL60_Human0.96805021
163CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96616478
164* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96291697
165EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96124616
166CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95428025
167RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94885418
168P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94296888
169YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94232844
170* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94007386
171CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93003090
172OCT4_19829295_ChIP-Seq_ESCs_Human0.92874303
173FOXA1_25329375_ChIP-Seq_VCAP_Human0.92635888
174FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92635888
175ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91686482
176HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90690940
177SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90601042
178CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86061167
179TFEB_21752829_ChIP-Seq_HELA_Human0.85499299
180ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83973250
181IRF1_19129219_ChIP-ChIP_H3396_Human0.82643525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.78225888
2MP0004957_abnormal_blastocyst_morpholog3.96969368
3MP0010094_abnormal_chromosome_stability3.79014102
4MP0003111_abnormal_nucleus_morphology3.61294375
5MP0003693_abnormal_embryo_hatching3.33845578
6MP0002653_abnormal_ependyma_morphology3.26231710
7MP0003077_abnormal_cell_cycle3.04445071
8MP0004133_heterotaxia2.90504391
9MP0008058_abnormal_DNA_repair2.77406948
10MP0003806_abnormal_nucleotide_metabolis2.54962509
11MP0008877_abnormal_DNA_methylation2.54636293
12MP0010368_abnormal_lymphatic_system2.51938542
13MP0010352_gastrointestinal_tract_polyps2.50618842
14MP0005410_abnormal_fertilization2.31705958
15MP0001730_embryonic_growth_arrest2.29782404
16MP0003890_abnormal_embryonic-extraembry2.24938805
17MP0003646_muscle_fatigue2.22823219
18MP0000350_abnormal_cell_proliferation2.18781104
19MP0003941_abnormal_skin_development2.17884288
20MP0000678_abnormal_parathyroid_gland2.15914488
21MP0008004_abnormal_stomach_pH2.13759609
22MP0008932_abnormal_embryonic_tissue2.13074485
23MP0003136_yellow_coat_color2.12953499
24MP0002084_abnormal_developmental_patter2.11036218
25MP0002085_abnormal_embryonic_tissue2.05599514
26MP0001672_abnormal_embryogenesis/_devel2.04119164
27MP0005380_embryogenesis_phenotype2.04119164
28MP0003283_abnormal_digestive_organ2.03380450
29MP0000569_abnormal_digit_pigmentation2.01413682
30MP0003119_abnormal_digestive_system1.95795255
31MP0004197_abnormal_fetal_growth/weight/1.93855529
32MP0003123_paternal_imprinting1.92454452
33MP0003786_premature_aging1.92028762
34MP0005174_abnormal_tail_pigmentation1.90952037
35MP0002086_abnormal_extraembryonic_tissu1.86043684
36MP0001697_abnormal_embryo_size1.84408864
37MP0001929_abnormal_gametogenesis1.83257106
38MP0002210_abnormal_sex_determination1.82643389
39MP0001293_anophthalmia1.77924522
40MP0010307_abnormal_tumor_latency1.73475320
41MP0005389_reproductive_system_phenotype1.71925210
42MP0010030_abnormal_orbit_morphology1.71532546
43MP0003984_embryonic_growth_retardation1.71324931
44MP0001145_abnormal_male_reproductive1.71175458
45MP0005076_abnormal_cell_differentiation1.70056515
46MP0000383_abnormal_hair_follicle1.69564058
47MP0002088_abnormal_embryonic_growth/wei1.68550771
48MP0002736_abnormal_nociception_after1.68511108
49MP0008007_abnormal_cellular_replicative1.65320422
50MP0006292_abnormal_olfactory_placode1.61890561
51MP0004264_abnormal_extraembryonic_tissu1.60309876
52MP0003705_abnormal_hypodermis_morpholog1.57535702
53MP0003698_abnormal_male_reproductive1.55654130
54MP0002080_prenatal_lethality1.54687792
55MP0003699_abnormal_female_reproductive1.41897209
56MP0003718_maternal_effect1.36319320
57MP0001968_abnormal_touch/_nociception1.35492082
58MP0000653_abnormal_sex_gland1.34873324
59MP0000015_abnormal_ear_pigmentation1.32165420
60MP0001849_ear_inflammation1.27808911
61MP0003121_genomic_imprinting1.26871345
62MP0001984_abnormal_olfaction1.21930512
63MP0010234_abnormal_vibrissa_follicle1.20731053
64MP0005266_abnormal_metabolism1.19417212
65MP0000313_abnormal_cell_death1.15958282
66MP0006035_abnormal_mitochondrial_morpho1.15541326
67MP0002095_abnormal_skin_pigmentation1.11823790
68MP0001879_abnormal_lymphatic_vessel1.11812005
69MP0004233_abnormal_muscle_weight1.09736114
70MP0000490_abnormal_crypts_of1.08103063
71MP0005367_renal/urinary_system_phenotyp1.07773907
72MP0000516_abnormal_urinary_system1.07773907
73MP0002249_abnormal_larynx_morphology1.07223273
74MP0002111_abnormal_tail_morphology1.06266606
75MP0003566_abnormal_cell_adhesion1.04790031
76MP0002161_abnormal_fertility/fecundity1.04167207
77MP0003567_abnormal_fetal_cardiomyocyte1.00553313
78MP0010678_abnormal_skin_adnexa0.98178207
79MP0001661_extended_life_span0.97823037
80MP0005310_abnormal_salivary_gland0.96149369
81MP0002019_abnormal_tumor_incidence0.95849682
82MP0005623_abnormal_meninges_morphology0.93910675
83MP0002822_catalepsy0.93225288
84MP0009278_abnormal_bone_marrow0.92884549
85MP0002796_impaired_skin_barrier0.91699827
86MP0003861_abnormal_nervous_system0.91527939
87MP0002332_abnormal_exercise_endurance0.91280416
88MP0002697_abnormal_eye_size0.91037403
89MP0008995_early_reproductive_senescence0.90639886
90MP0005670_abnormal_white_adipose0.90273920
91MP0002092_abnormal_eye_morphology0.90043816
92MP0005409_darkened_coat_color0.88393698
93MP0001188_hyperpigmentation0.87974896
94MP0009053_abnormal_anal_canal0.87789102
95MP0005501_abnormal_skin_physiology0.87775999
96MP0001286_abnormal_eye_development0.86361014
97MP0009703_decreased_birth_body0.85980006
98MP0000432_abnormal_head_morphology0.85697190
99MP0002160_abnormal_reproductive_system0.82934808
100MP0004742_abnormal_vestibular_system0.82563688
101MP0003880_abnormal_central_pattern0.82556095
102MP0005058_abnormal_lysosome_morphology0.82191539
103MP0003936_abnormal_reproductive_system0.81579720
104MP0008789_abnormal_olfactory_epithelium0.81073046
105MP0003315_abnormal_perineum_morphology0.79578025
106MP0000427_abnormal_hair_cycle0.79214121
107MP0001486_abnormal_startle_reflex0.78735988
108MP0003937_abnormal_limbs/digits/tail_de0.78139238
109MP0000371_diluted_coat_color0.76922138
110MP0005551_abnormal_eye_electrophysiolog0.76617651
111MP0002735_abnormal_chemical_nociception0.76508053
112MP0001348_abnormal_lacrimal_gland0.76297723
113MP0005023_abnormal_wound_healing0.76018162
114MP0006072_abnormal_retinal_apoptosis0.73207496
115MP0003755_abnormal_palate_morphology0.72904983
116MP0000358_abnormal_cell_content/0.72171541
117MP0003935_abnormal_craniofacial_develop0.72021557
118MP0002127_abnormal_cardiovascular_syste0.71976591
119MP0002269_muscular_atrophy0.71742623
120MP0005647_abnormal_sex_gland0.71610902
121MP0002925_abnormal_cardiovascular_devel0.70585881
122MP0000631_abnormal_neuroendocrine_gland0.69576210
123MP0000537_abnormal_urethra_morphology0.69546789
124MP0005423_abnormal_somatic_nervous0.68941341
125MP0001764_abnormal_homeostasis0.66594281
126MP0003453_abnormal_keratinocyte_physiol0.66548398
127MP0008770_decreased_survivor_rate0.65642455
128MP0001919_abnormal_reproductive_system0.65573581
129MP0004185_abnormal_adipocyte_glucose0.65396968
130MP0000467_abnormal_esophagus_morphology0.64707000
131MP0001915_intracranial_hemorrhage0.64544378
132MP0002114_abnormal_axial_skeleton0.64437885
133MP0005384_cellular_phenotype0.63338980
134MP0002067_abnormal_sensory_capabilities0.62891888
135MP0003959_abnormal_lean_body0.62423023
136MP0005395_other_phenotype0.62319940
137MP0002254_reproductive_system_inflammat0.61999951
138MP0002075_abnormal_coat/hair_pigmentati0.61626786
139MP0005379_endocrine/exocrine_gland_phen0.61310775
140MP0001119_abnormal_female_reproductive0.59969302
141MP0003943_abnormal_hepatobiliary_system0.59648889
142MP0005377_hearing/vestibular/ear_phenot0.59318545
143MP0003878_abnormal_ear_physiology0.59318545
144MP0000647_abnormal_sebaceous_gland0.58453775
145MP0005499_abnormal_olfactory_system0.57188391
146MP0005394_taste/olfaction_phenotype0.57188391
147MP0002163_abnormal_gland_morphology0.56640976
148MP0000955_abnormal_spinal_cord0.53862855
149MP0002272_abnormal_nervous_system0.53512602
150MP0001963_abnormal_hearing_physiology0.51511305
151MP0000026_abnormal_inner_ear0.50017381
152MP0005646_abnormal_pituitary_gland0.49015168
153MP0002971_abnormal_brown_adipose0.47189682
154MP0000566_synostosis0.45786443
155MP0000049_abnormal_middle_ear0.45250139
156MP0002229_neurodegeneration0.45089094
157MP0009745_abnormal_behavioral_response0.43101020

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.53945104
2Gonadotropin excess (HP:0000837)4.82724970
3Shoulder girdle muscle weakness (HP:0003547)4.74615377
4Osteomalacia (HP:0002749)4.56131222
5Upper motor neuron abnormality (HP:0002127)4.49042008
6Absent/shortened dynein arms (HP:0200106)4.39574011
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.39574011
8Severe visual impairment (HP:0001141)4.23900732
9Rib fusion (HP:0000902)4.22596084
10Abnormality of the astrocytes (HP:0100707)4.14814259
11Astrocytoma (HP:0009592)4.14814259
12Horizontal nystagmus (HP:0000666)4.13792544
13Supernumerary spleens (HP:0009799)4.08330233
14Abnormality of the labia minora (HP:0012880)4.06127261
15Volvulus (HP:0002580)3.98711930
16Azoospermia (HP:0000027)3.90770123
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.84392782
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.84392782
19Aplasia/hypoplasia of the humerus (HP:0006507)3.80519446
20Short humerus (HP:0005792)3.76180953
21Resting tremor (HP:0002322)3.71041742
22Neoplasm of the oral cavity (HP:0100649)3.64926991
23Medulloblastoma (HP:0002885)3.63795240
24Oligodactyly (hands) (HP:0001180)3.63447793
25Abnormality of the lower motor neuron (HP:0002366)3.61226214
26Absent radius (HP:0003974)3.60281566
27Rectovaginal fistula (HP:0000143)3.56282162
28Rectal fistula (HP:0100590)3.56282162
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.55768470
30Rhabdomyosarcoma (HP:0002859)3.54426678
31Scotoma (HP:0000575)3.45969114
32Tubulointerstitial nephritis (HP:0001970)3.43374541
33Selective tooth agenesis (HP:0001592)3.41794101
34Abnormality of abdominal situs (HP:0011620)3.39678882
35Abdominal situs inversus (HP:0003363)3.39678882
36Aplasia involving forearm bones (HP:0009822)3.38210983
37Absent forearm bone (HP:0003953)3.38210983
38Missing ribs (HP:0000921)3.35178107
39Chromsome breakage (HP:0040012)3.34121605
40Breast hypoplasia (HP:0003187)3.31330119
41Impulsivity (HP:0100710)3.31051431
42Glioma (HP:0009733)3.25824391
43Abnormal spermatogenesis (HP:0008669)3.22967818
44Neoplasm of striated muscle (HP:0009728)3.19084491
45Abnormal ciliary motility (HP:0012262)3.15702989
46Intestinal fistula (HP:0100819)3.12688892
47Agnosia (HP:0010524)3.12215052
48Spontaneous abortion (HP:0005268)3.08284194
49Abnormality of the corticospinal tract (HP:0002492)3.07438536
50Abnormal respiratory epithelium morphology (HP:0012253)3.04182385
51Abnormal respiratory motile cilium morphology (HP:0005938)3.04182385
52Absent thumb (HP:0009777)3.04170442
53Nephronophthisis (HP:0000090)3.02997575
54Vaginal fistula (HP:0004320)2.99366476
55Abnormal respiratory motile cilium physiology (HP:0012261)2.95937944
56Rimmed vacuoles (HP:0003805)2.95539240
57Truncal obesity (HP:0001956)2.89793793
58Abnormality of the salivary glands (HP:0010286)2.78886933
59Shawl scrotum (HP:0000049)2.74285539
60Birth length less than 3rd percentile (HP:0003561)2.73314088
61Esophageal atresia (HP:0002032)2.71668345
62Oligodactyly (HP:0012165)2.71360328
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.66481001
64Abnormality of the ileum (HP:0001549)2.65541203
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.64710853
66Capillary hemangiomas (HP:0005306)2.63109085
67Colon cancer (HP:0003003)2.61483933
68Abnormality of the renal medulla (HP:0100957)2.60353320
69Carpal bone hypoplasia (HP:0001498)2.59788787
70Meckel diverticulum (HP:0002245)2.55592871
71Infertility (HP:0000789)2.54243347
72Basal cell carcinoma (HP:0002671)2.53659885
73Hyperkalemia (HP:0002153)2.48799761
74Patellar aplasia (HP:0006443)2.47425602
75Reticulocytopenia (HP:0001896)2.45986497
76Asplenia (HP:0001746)2.45113276
77Abnormality of macular pigmentation (HP:0008002)2.42840919
78Abnormal lung lobation (HP:0002101)2.40412221
79Limb-girdle muscle weakness (HP:0003325)2.38495588
80Urinary urgency (HP:0000012)2.38073871
81Increased nuchal translucency (HP:0010880)2.37613377
82Supernumerary ribs (HP:0005815)2.36993437
83Broad distal phalanx of finger (HP:0009836)2.36305488
84Male pseudohermaphroditism (HP:0000037)2.36161300
85Pseudobulbar signs (HP:0002200)2.34948750
86Chronic hepatic failure (HP:0100626)2.33555438
87Vertebral clefting (HP:0008428)2.32969813
88Tubulointerstitial abnormality (HP:0001969)2.32798567
89Supernumerary bones of the axial skeleton (HP:0009144)2.32227409
90Megalencephaly (HP:0001355)2.29587173
91Premature ovarian failure (HP:0008209)2.29360868
92Congenital sensorineural hearing impairment (HP:0008527)2.29280742
93Abnormality of the costochondral junction (HP:0000919)2.28170388
94Abnormality of chromosome stability (HP:0003220)2.28150287
95Abnormality of the preputium (HP:0100587)2.27103198
96Aplasia/Hypoplasia of the spleen (HP:0010451)2.25782661
97Vertebral fusion (HP:0002948)2.25516058
98Hypoplasia of the uterus (HP:0000013)2.24984497
99Gastrointestinal atresia (HP:0002589)2.24208952
100Aplasia/Hypoplasia of the patella (HP:0006498)2.22041220
101Hypochromic microcytic anemia (HP:0004840)2.21951565
102Trismus (HP:0000211)2.21001869
103Facial hemangioma (HP:0000329)2.20636227
104Aplasia/Hypoplasia of the earlobes (HP:0009906)2.19362057
105Sex reversal (HP:0012245)2.17638457
106Abnormal sex determination (HP:0012244)2.17638457
107Degeneration of anterior horn cells (HP:0002398)2.16596182
108Abnormality of the anterior horn cell (HP:0006802)2.16596182
109Delayed epiphyseal ossification (HP:0002663)2.16238188
110Nephroblastoma (Wilms tumor) (HP:0002667)2.14582408
111Fused cervical vertebrae (HP:0002949)2.10213251
112Atrophy/Degeneration involving motor neurons (HP:0007373)2.08939832
113Hemivertebrae (HP:0002937)2.08715084
114Biliary tract neoplasm (HP:0100574)2.08409687
115Occipital encephalocele (HP:0002085)2.07688324
116Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.04190198
117Vertebral hypoplasia (HP:0008417)2.04190198
118Retinal dysplasia (HP:0007973)2.03979207
119Abnormal number of incisors (HP:0011064)2.03362996
120Menstrual irregularities (HP:0000858)2.00960370
121Duodenal stenosis (HP:0100867)2.00669235
122Small intestinal stenosis (HP:0012848)2.00669235
123Hyperventilation (HP:0002883)1.99872667
124Duplicated collecting system (HP:0000081)1.99673983
125Astigmatism (HP:0000483)1.99065299
126Absent speech (HP:0001344)1.98242127
127Abnormality of chromosome segregation (HP:0002916)1.98177628
128Metaphyseal cupping (HP:0003021)1.95864477
129Male infertility (HP:0003251)1.95823242
130Tongue fasciculations (HP:0001308)1.95402912
131Widely spaced teeth (HP:0000687)1.95394535
132Bilateral microphthalmos (HP:0007633)1.95138276
13311 pairs of ribs (HP:0000878)1.95104169
134Type II lissencephaly (HP:0007260)1.95093908
135Embryonal renal neoplasm (HP:0011794)1.94955407
136High anterior hairline (HP:0009890)1.94459737
137Tracheoesophageal fistula (HP:0002575)1.94398423
138Multiple enchondromatosis (HP:0005701)1.94294640
139Abnormality of DNA repair (HP:0003254)1.92828217
140Sloping forehead (HP:0000340)1.90799639
141Abnormality of cells of the erythroid lineage (HP:0012130)1.87787872
142Heterotopia (HP:0002282)1.87053445
143Myelodysplasia (HP:0002863)1.86047080
144Microglossia (HP:0000171)1.84976937
145Proximal placement of thumb (HP:0009623)1.84812486
146Abnormality of pyrimidine metabolism (HP:0004353)1.84755535
147Short 1st metacarpal (HP:0010034)1.84363074
148Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.84363074
149Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84338526
150Angiofibromas (HP:0010615)1.83758646
151Adenoma sebaceum (HP:0009720)1.83758646
152Rickets (HP:0002748)1.82453805
153Spinal muscular atrophy (HP:0007269)1.81712553
154Abnormality of the duodenum (HP:0002246)1.81708529
155Intellectual disability, moderate (HP:0002342)1.80834814
156Aplasia/Hypoplasia of the sternum (HP:0006714)1.80510889
157Delayed puberty (HP:0000823)1.79575341
158Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78647584
159Abnormal protein N-linked glycosylation (HP:0012347)1.78647584
160Abnormal protein glycosylation (HP:0012346)1.78647584
161Abnormal glycosylation (HP:0012345)1.78647584
162Deviation of the thumb (HP:0009603)1.78216230
163Muscle fibrillation (HP:0010546)1.78151436
164Short thumb (HP:0009778)1.77503351
165Squamous cell carcinoma (HP:0002860)1.77082351
166Embryonal neoplasm (HP:0002898)1.77025787
167Ectopic kidney (HP:0000086)1.76694703
168Vertebral arch anomaly (HP:0008438)1.76212029
169Enlarged epiphyses (HP:0010580)1.75857432
170Amyotrophic lateral sclerosis (HP:0007354)1.75719421
171Cafe-au-lait spot (HP:0000957)1.75407118
172Cystic liver disease (HP:0006706)1.75206307
173Abnormality of the vocal cords (HP:0008777)1.75102974
174Abnormality of the renal collecting system (HP:0004742)1.71491356
175Central scotoma (HP:0000603)1.71265497
176Flattened epiphyses (HP:0003071)1.70478165
177Postural instability (HP:0002172)1.68941368
178Abnormality of the aortic arch (HP:0012303)1.68206646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.39887169
2EPHA23.87274350
3CDK193.85281600
4PLK43.55374030
5ICK3.17113663
6WEE13.15878643
7CDC73.04532204
8TTK2.76187277
9RPS6KB22.53065474
10TLK12.52037306
11PINK12.43576366
12NEK22.41584182
13BUB12.35355380
14CAMK1G2.33704452
15MST1R2.31926912
16CDK72.23757332
17AKT32.11755497
18PDK32.07592196
19PDK42.07592196
20NEK12.01353767
21PTK2B2.00444177
22PLK11.93327185
23CHEK21.79226101
24TYRO31.72545448
25MAPKAPK31.66947413
26PDK21.56793329
27NEK91.49966665
28BRD41.49332239
29BRAF1.48098246
30MAP4K21.43425102
31CHEK11.41281927
32DYRK31.38125756
33MARK31.36302271
34ATR1.36187928
35LATS21.30908531
36SRPK11.27753135
37AURKA1.26927624
38PNCK1.25457275
39FLT31.23803562
40PASK1.23009849
41PLK21.22753106
42CDK41.20963305
43AURKB1.20066547
44STK38L1.19339003
45ALK1.14730110
46OXSR11.12716386
47MAP3K101.11756840
48WNK11.11551562
49MAP3K21.10711079
50DDR21.09365063
51KSR21.07799408
52MTOR1.07409756
53CDK21.04992215
54PIM11.04822386
55PAK41.02579959
56ATM1.02459047
57STK41.01801983
58TSSK61.01720530
59CLK11.01493801
60TESK20.99764218
61STK100.98941312
62MATK0.98589092
63TESK10.98092147
64FGFR10.97718967
65MAP3K80.97096674
66BRSK20.96891633
67ZAK0.95906414
68EEF2K0.92665193
69ACVR1B0.92634670
70PDGFRB0.92236777
71WNK40.90763860
72MET0.90506479
73CSF1R0.88788568
74VRK10.88075646
75EIF2AK10.87124455
76SCYL20.85954817
77PRKD30.84745536
78BMX0.82579594
79RET0.82549052
80MAP3K60.79805618
81SGK10.79608133
82PRKCI0.79043159
83RPS6KB10.75031884
84INSRR0.74919745
85KSR10.74427941
86CDK60.73010910
87MAP3K130.72447367
88PKN20.70761217
89PLK30.70439042
90STK240.70307229
91CDK10.67472280
92STK160.67357721
93NTRK30.66057490
94CSNK1D0.65609321
95GRK60.64299966
96STK380.64132577
97MAPK150.63184250
98CSNK1E0.62990931
99CSNK2A20.62571026
100STK390.62358804
101EPHA40.61801809
102AKT20.61670350
103CASK0.61583232
104PAK10.60873914
105MKNK20.60802773
106CDK30.60795424
107CDK80.59652621
108NEK60.59472320
109ERBB40.57048078
110FGR0.56382113
111PRKCZ0.55700263
112PDK10.54665761
113MAP3K110.54057421
114PDPK10.53899898
115NME20.52720952
116MAP3K90.51008128
117YES10.49994606
118DYRK1B0.49033518
119EGFR0.48047933
120PDGFRA0.47074403
121MAP3K10.46953390
122DYRK20.46781550
123DYRK1A0.46245533
124LATS10.44779277
125RPS6KA50.44372092
126STK30.44179341
127CSK0.43888175
128CSNK2A10.43887390
129PHKG10.43681648
130PHKG20.43681648
131CCNB10.42847509
132MAPK140.42368988
133MELK0.42167134
134MAPK10.41502126
135MINK10.41152077
136PRKDC0.39630011
137GSK3B0.39591188
138DAPK10.39148494
139BRSK10.36409774
140MKNK10.35018689
141CDK11A0.34087853
142BCKDK0.33927193
143RPS6KA10.32902030
144PRKG10.32094029
145SGK2230.31339879
146SGK4940.31339879
147AKT10.31240031
148RIPK10.31197694
149CAMK10.31131600
150NLK0.28149794
151PIK3CG0.27548433
152MAP3K50.25677265

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.72601696
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.31523913
3DNA replication_Homo sapiens_hsa030304.31451412
4RNA transport_Homo sapiens_hsa030133.47699599
5One carbon pool by folate_Homo sapiens_hsa006703.14016071
6* Spliceosome_Homo sapiens_hsa030402.91585088
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.82921134
8Base excision repair_Homo sapiens_hsa034102.80528965
9Nucleotide excision repair_Homo sapiens_hsa034202.75546143
10Ribosome_Homo sapiens_hsa030102.72121397
11Fanconi anemia pathway_Homo sapiens_hsa034602.71331233
12Homologous recombination_Homo sapiens_hsa034402.64663276
13mRNA surveillance pathway_Homo sapiens_hsa030152.43367645
14Cell cycle_Homo sapiens_hsa041102.31676917
15RNA polymerase_Homo sapiens_hsa030202.27173010
16Regulation of autophagy_Homo sapiens_hsa041402.07044245
17Basal transcription factors_Homo sapiens_hsa030222.03030048
18Systemic lupus erythematosus_Homo sapiens_hsa053221.90482239
19Non-homologous end-joining_Homo sapiens_hsa034501.65463889
20Nicotine addiction_Homo sapiens_hsa050331.64693775
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61931622
22RNA degradation_Homo sapiens_hsa030181.61076836
23Pyrimidine metabolism_Homo sapiens_hsa002401.60811218
24p53 signaling pathway_Homo sapiens_hsa041151.58394022
25Biosynthesis of amino acids_Homo sapiens_hsa012301.53481842
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47419488
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.42575690
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.41392040
29Selenocompound metabolism_Homo sapiens_hsa004501.35741836
30Butanoate metabolism_Homo sapiens_hsa006501.33781913
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.28548441
32Propanoate metabolism_Homo sapiens_hsa006401.28390929
33Olfactory transduction_Homo sapiens_hsa047401.24614903
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23222255
35Vitamin B6 metabolism_Homo sapiens_hsa007501.19944165
36Oocyte meiosis_Homo sapiens_hsa041141.15859812
37Proteasome_Homo sapiens_hsa030501.15247393
38Hippo signaling pathway_Homo sapiens_hsa043901.14830362
39Fructose and mannose metabolism_Homo sapiens_hsa000511.12128955
40Basal cell carcinoma_Homo sapiens_hsa052171.11069338
41beta-Alanine metabolism_Homo sapiens_hsa004101.09826107
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05136923
43Viral carcinogenesis_Homo sapiens_hsa052031.00938522
44Type II diabetes mellitus_Homo sapiens_hsa049300.99614047
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99478343
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99253368
47Notch signaling pathway_Homo sapiens_hsa043300.98484505
48Fatty acid biosynthesis_Homo sapiens_hsa000610.96565225
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.96302855
50Fatty acid degradation_Homo sapiens_hsa000710.96201929
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95827265
52Hedgehog signaling pathway_Homo sapiens_hsa043400.94861399
53Circadian rhythm_Homo sapiens_hsa047100.88584426
54Phenylalanine metabolism_Homo sapiens_hsa003600.87454789
55Alcoholism_Homo sapiens_hsa050340.86057161
56ErbB signaling pathway_Homo sapiens_hsa040120.84822792
57Fatty acid metabolism_Homo sapiens_hsa012120.84354977
58mTOR signaling pathway_Homo sapiens_hsa041500.83981056
59Morphine addiction_Homo sapiens_hsa050320.83125571
60Carbon metabolism_Homo sapiens_hsa012000.82357521
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82165020
62Gap junction_Homo sapiens_hsa045400.81784713
63TGF-beta signaling pathway_Homo sapiens_hsa043500.81513270
64Folate biosynthesis_Homo sapiens_hsa007900.81307282
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77742683
66MicroRNAs in cancer_Homo sapiens_hsa052060.77531015
67N-Glycan biosynthesis_Homo sapiens_hsa005100.77431324
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.76740597
69Purine metabolism_Homo sapiens_hsa002300.73095615
70Adherens junction_Homo sapiens_hsa045200.72119098
71Thyroid cancer_Homo sapiens_hsa052160.71051070
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69878626
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69760667
74Epstein-Barr virus infection_Homo sapiens_hsa051690.69671074
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.67852480
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66860871
77Bladder cancer_Homo sapiens_hsa052190.65132934
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64477462
79Tight junction_Homo sapiens_hsa045300.63683649
80Choline metabolism in cancer_Homo sapiens_hsa052310.63267199
81Lysine degradation_Homo sapiens_hsa003100.62889542
82Linoleic acid metabolism_Homo sapiens_hsa005910.62298062
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62104583
84Pentose phosphate pathway_Homo sapiens_hsa000300.61676987
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58508120
86Sulfur relay system_Homo sapiens_hsa041220.56933965
87Nitrogen metabolism_Homo sapiens_hsa009100.55703677
88Arginine and proline metabolism_Homo sapiens_hsa003300.55562085
89Glutathione metabolism_Homo sapiens_hsa004800.53566649
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52726496
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52701581
92Prolactin signaling pathway_Homo sapiens_hsa049170.52176595
93Herpes simplex infection_Homo sapiens_hsa051680.50648189
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49870257
95HTLV-I infection_Homo sapiens_hsa051660.49328916
96Endometrial cancer_Homo sapiens_hsa052130.46641154
97Galactose metabolism_Homo sapiens_hsa000520.46576521
98Glycerolipid metabolism_Homo sapiens_hsa005610.46030368
99Wnt signaling pathway_Homo sapiens_hsa043100.45892826
100Taste transduction_Homo sapiens_hsa047420.43316468
101Pyruvate metabolism_Homo sapiens_hsa006200.41999872
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.41641194
103Calcium signaling pathway_Homo sapiens_hsa040200.40704586
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40166502
105VEGF signaling pathway_Homo sapiens_hsa043700.37227192
106FoxO signaling pathway_Homo sapiens_hsa040680.35886597
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35879841
108Pathways in cancer_Homo sapiens_hsa052000.35408345
109Small cell lung cancer_Homo sapiens_hsa052220.34034659
110Ether lipid metabolism_Homo sapiens_hsa005650.32869021
111Phototransduction_Homo sapiens_hsa047440.32599872
112Huntingtons disease_Homo sapiens_hsa050160.32228178
113Arachidonic acid metabolism_Homo sapiens_hsa005900.30555881
114Colorectal cancer_Homo sapiens_hsa052100.30326833
115Glioma_Homo sapiens_hsa052140.29506667
116Endocytosis_Homo sapiens_hsa041440.28475290
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.27928153
118Arginine biosynthesis_Homo sapiens_hsa002200.27926428
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27797453
120MAPK signaling pathway_Homo sapiens_hsa040100.27461572
121Dorso-ventral axis formation_Homo sapiens_hsa043200.25938234
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25625962
123Antigen processing and presentation_Homo sapiens_hsa046120.25487628
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24725043
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24553097
126Estrogen signaling pathway_Homo sapiens_hsa049150.23798471
127Glutamatergic synapse_Homo sapiens_hsa047240.23607714
128HIF-1 signaling pathway_Homo sapiens_hsa040660.22127341
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20745410
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20047352
131cAMP signaling pathway_Homo sapiens_hsa040240.19772394
132Retinol metabolism_Homo sapiens_hsa008300.19622335
133Non-small cell lung cancer_Homo sapiens_hsa052230.19169093
134Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18278367
135Melanoma_Homo sapiens_hsa052180.18212822
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.17797358
137Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17082710
138Glucagon signaling pathway_Homo sapiens_hsa049220.16612607
139AMPK signaling pathway_Homo sapiens_hsa041520.15227780
140Apoptosis_Homo sapiens_hsa042100.15043284
141Metabolic pathways_Homo sapiens_hsa011000.14058523
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13226764
143T cell receptor signaling pathway_Homo sapiens_hsa046600.13081935
144Inositol phosphate metabolism_Homo sapiens_hsa005620.11856721
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11258568
146Acute myeloid leukemia_Homo sapiens_hsa052210.07854606
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.06204258
148Legionellosis_Homo sapiens_hsa051340.05411947
149Prostate cancer_Homo sapiens_hsa052150.05159870

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