ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-fucose catabolic process (GO:0042355)	5.81657394
2	fucose catabolic process (GO:0019317)	5.81657394
3	L-fucose metabolic process (GO:0042354)	5.81657394
4	cullin deneddylation (GO:0010388)	5.19884653
5	protein deneddylation (GO:0000338)	5.04373173
6	DNA deamination (GO:0045006)	4.65059751
7	protein neddylation (GO:0045116)	4.64610995
8	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.39760350
9	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.22215239
10	platelet dense granule organization (GO:0060155)	4.07936988
11	negative regulation of mast cell activation (GO:0033004)	4.03878435
12	protein-cofactor linkage (GO:0018065)	3.83004809
13	behavioral response to ethanol (GO:0048149)	3.69436975
14	inositol phosphate dephosphorylation (GO:0046855)	3.68559561
15	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.68559561
16	peptidyl-histidine modification (GO:0018202)	3.55069155
17	mitochondrial respiratory chain complex assembly (GO:0033108)	3.52091675
18	protein complex biogenesis (GO:0070271)	3.45236627
19	neuronal action potential propagation (GO:0019227)	3.39279236
20	inositol phosphate catabolic process (GO:0071545)	3.36742041
21	fusion of sperm to egg plasma membrane (GO:0007342)	3.36089389
22	proteasome assembly (GO:0043248)	3.30650798
23	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.22962363
24	telomere maintenance via semi-conservative replication (GO:0032201)	3.20041943
25	aggressive behavior (GO:0002118)	3.17548481
26	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.16120758
27	DNA damage response, detection of DNA damage (GO:0042769)	3.12745337
28	fucosylation (GO:0036065)	3.09169325
29	histone H2A acetylation (GO:0043968)	3.07568579
30	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.05896631
31	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.05896631
32	glutathione biosynthetic process (GO:0006750)	3.05852953
33	daunorubicin metabolic process (GO:0044597)	3.04760985
34	polyketide metabolic process (GO:0030638)	3.04760985
35	doxorubicin metabolic process (GO:0044598)	3.04760985
36	nonribosomal peptide biosynthetic process (GO:0019184)	3.01681691
37	negative regulation of membrane potential (GO:0045837)	3.00133871
38	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.99616113
39	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.98979729
40	telomere maintenance via recombination (GO:0000722)	2.97636874
41	ATP synthesis coupled proton transport (GO:0015986)	2.97450727
42	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.97450727
43	water-soluble vitamin biosynthetic process (GO:0042364)	2.96719713
44	respiratory chain complex IV assembly (GO:0008535)	2.95758518
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.93514547
46	NADH dehydrogenase complex assembly (GO:0010257)	2.93514547
47	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.93514547
48	response to pheromone (GO:0019236)	2.93211910
49	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.93097441
50	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.93097441
51	dendritic spine morphogenesis (GO:0060997)	2.88863830
52	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.87269895
53	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.86313973
54	sequestering of actin monomers (GO:0042989)	2.85842835
55	cytochrome complex assembly (GO:0017004)	2.81943942
56	immunoglobulin mediated immune response (GO:0016064)	2.81126494
57	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.80265907
58	cell migration in hindbrain (GO:0021535)	2.79840232
59	negative regulation of telomere maintenance (GO:0032205)	2.79839070
60	resolution of meiotic recombination intermediates (GO:0000712)	2.79688265
61	intraciliary transport (GO:0042073)	2.79582785
62	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.78325213
63	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.78325213
64	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.78325213
65	tryptophan catabolic process (GO:0006569)	2.78079293
66	indole-containing compound catabolic process (GO:0042436)	2.78079293
67	indolalkylamine catabolic process (GO:0046218)	2.78079293
68	replication fork processing (GO:0031297)	2.76083792
69	tyrosine phosphorylation of STAT protein (GO:0007260)	2.74666698
70	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.73673533
71	aminoglycoside antibiotic metabolic process (GO:0030647)	2.73613718
72	base-excision repair, AP site formation (GO:0006285)	2.70725115
73	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.69632295
74	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.69632295
75	telomere maintenance via telomere lengthening (GO:0010833)	2.67479084
76	S-adenosylmethionine metabolic process (GO:0046500)	2.67270088
77	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.65718304
78	fucose metabolic process (GO:0006004)	2.65596940
79	regulation of cellular amino acid metabolic process (GO:0006521)	2.65578381
80	neuron fate determination (GO:0048664)	2.65225048
81	neurotransmitter-gated ion channel clustering (GO:0072578)	2.64065221
82	branched-chain amino acid catabolic process (GO:0009083)	2.62619787
83	ubiquinone metabolic process (GO:0006743)	2.62473416
84	plasma membrane fusion (GO:0045026)	2.62419563
85	secretory granule organization (GO:0033363)	2.61445012
86	mitotic recombination (GO:0006312)	2.60516679
87	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.59271876
88	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.59095437
89	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	2.58365691
90	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	2.58365691
91	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.57794554
92	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.57794554
93	ubiquinone biosynthetic process (GO:0006744)	2.57369846
94	behavioral response to nicotine (GO:0035095)	2.56116748
95	multicellular organism reproduction (GO:0032504)	2.53700225
96	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.53551643
97	auditory receptor cell stereocilium organization (GO:0060088)	2.53321348
98	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	2.52000729
99	tryptophan metabolic process (GO:0006568)	2.50658942
100	chaperone-mediated protein transport (GO:0072321)	2.50606624

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.79101156
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.65845211
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.36575293
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.31677604
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.91383146
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.80489786
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.73492016
8	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.66667626
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.60163417
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.53713860
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.52199313
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.51487029
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.43508304
14	EWS_26573619_Chip-Seq_HEK293_Human	2.40775232
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.37814056
16	IRF1_19129219_ChIP-ChIP_H3396_Human	2.32927627
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.21266206
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.09790915
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.07933139
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.06684175
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.04354269
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.02394953
23	FUS_26573619_Chip-Seq_HEK293_Human	2.02225721
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.98247815
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.97409339
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.93561318
27	VDR_22108803_ChIP-Seq_LS180_Human	1.92417841
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.87044422
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.85454767
30	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.80560945
31	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.76787719
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.76609155
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.75039811
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.71265049
35	P300_19829295_ChIP-Seq_ESCs_Human	1.66740782
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.63790391
37	RNF2_27304074_Chip-Seq_NSC_Mouse	1.57558939
38	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.51622800
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.49758597
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47114367
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.45501411
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.44176802
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43478295
44	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.43238837
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.41964435
46	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.40596855
47	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.36776523
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34292007
49	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.30478731
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.29577918
51	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.28799028
52	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.28673966
53	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.26944156
54	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.25864930
55	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.25683769
56	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24686939
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18801242
58	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.18048749
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17366525
60	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.17114140
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16566802
62	CIITA_25753668_ChIP-Seq_RAJI_Human	1.14672328
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13024846
64	GABP_19822575_ChIP-Seq_HepG2_Human	1.12447557
65	GBX2_23144817_ChIP-Seq_PC3_Human	1.11256929
66	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.10466532
67	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.08925086
68	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07094917
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05100433
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05100433
71	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.04721775
72	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.03375836
73	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.01688860
74	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00828734
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99462381
76	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.95122384
77	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.94716671
78	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94232711
79	CBP_20019798_ChIP-Seq_JUKART_Human	0.94232711
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93524955
81	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.93377347
82	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.92737019
83	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.92004969
84	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.90688294
85	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.88799307
86	DCP1A_22483619_ChIP-Seq_HELA_Human	0.88712901
87	HOXB7_26014856_ChIP-Seq_BT474_Human	0.88666565
88	AR_20517297_ChIP-Seq_VCAP_Human	0.88306098
89	TTF2_22483619_ChIP-Seq_HELA_Human	0.88078634
90	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.87855169
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.87352912
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.87217827
93	NCOR_22424771_ChIP-Seq_293T_Human	0.86637380
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.86406000
95	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.85909328
96	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.85365504
97	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.84717296
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.83010074
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.82961649
100	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.82933888

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	5.94256517
2	MP0005084_abnormal_gallbladder_morpholo	4.35417863
3	MP0001529_abnormal_vocalization	3.44415012
4	MP0002102_abnormal_ear_morphology	3.21554176
5	MP0006292_abnormal_olfactory_placode	3.20425903
6	MP0010386_abnormal_urinary_bladder	2.93937880
7	MP0005085_abnormal_gallbladder_physiolo	2.58402431
8	MP0001968_abnormal_touch/_nociception	2.41116774
9	MP0005646_abnormal_pituitary_gland	2.33754190
10	MP0006072_abnormal_retinal_apoptosis	2.27237923
11	MP0006276_abnormal_autonomic_nervous	2.04751150
12	MP0006054_spinal_hemorrhage	2.01667493
13	MP0008058_abnormal_DNA_repair	1.99803999
14	MP0004133_heterotaxia	1.85777357
15	MP0003303_peritoneal_inflammation	1.84841878
16	MP0001764_abnormal_homeostasis	1.84585545
17	MP0001293_anophthalmia	1.71549004
18	MP0003880_abnormal_central_pattern	1.67740535
19	MP0004885_abnormal_endolymph	1.63791031
20	MP0000631_abnormal_neuroendocrine_gland	1.57469294
21	MP0002733_abnormal_thermal_nociception	1.57360913
22	MP0008875_abnormal_xenobiotic_pharmacok	1.56233488
23	MP0000537_abnormal_urethra_morphology	1.55587206
24	MP0008872_abnormal_physiological_respon	1.54161264
25	MP0002736_abnormal_nociception_after	1.48590973
26	MP0001664_abnormal_digestion	1.47226715
27	MP0004043_abnormal_pH_regulation	1.41354060
28	MP0002272_abnormal_nervous_system	1.39308924
29	MP0009046_muscle_twitch	1.36567004
30	MP0008995_early_reproductive_senescence	1.33251107
31	MP0001835_abnormal_antigen_presentation	1.31605364
32	MP0000465_gastrointestinal_hemorrhage	1.30107289
33	MP0003890_abnormal_embryonic-extraembry	1.29391767
34	MP0000613_abnormal_salivary_gland	1.27436630
35	MP0005367_renal/urinary_system_phenotyp	1.26010779
36	MP0000516_abnormal_urinary_system	1.26010779
37	MP0006036_abnormal_mitochondrial_physio	1.25623003
38	MP0000049_abnormal_middle_ear	1.23582940
39	MP0004742_abnormal_vestibular_system	1.22879884
40	MP0001486_abnormal_startle_reflex	1.22638585
41	MP0003724_increased_susceptibility_to	1.22338787
42	MP0008789_abnormal_olfactory_epithelium	1.21022736
43	MP0005253_abnormal_eye_physiology	1.20989974
44	MP0002638_abnormal_pupillary_reflex	1.19537723
45	MP0003693_abnormal_embryo_hatching	1.16960774
46	MP0001501_abnormal_sleep_pattern	1.15716225
47	MP0004142_abnormal_muscle_tone	1.14858921
48	MP0001970_abnormal_pain_threshold	1.14281738
49	MP0005551_abnormal_eye_electrophysiolog	1.14083360
50	MP0005075_abnormal_melanosome_morpholog	1.13988322
51	MP0005410_abnormal_fertilization	1.13203203
52	MP0001485_abnormal_pinna_reflex	1.11093817
53	MP0000538_abnormal_urinary_bladder	1.09231770
54	MP0003252_abnormal_bile_duct	1.04817016
55	MP0009745_abnormal_behavioral_response	1.02620036
56	MP0002938_white_spotting	1.01612324
57	MP0003119_abnormal_digestive_system	0.99783443
58	MP0001663_abnormal_digestive_system	0.99298379
59	MP0003137_abnormal_impulse_conducting	0.99011790
60	MP0005187_abnormal_penis_morphology	0.98954758
61	MP0002234_abnormal_pharynx_morphology	0.98056859
62	MP0002557_abnormal_social/conspecific_i	0.97463361
63	MP0003806_abnormal_nucleotide_metabolis	0.95100130
64	MP0003195_calcinosis	0.94973452
65	MP0005645_abnormal_hypothalamus_physiol	0.93073864
66	MP0003718_maternal_effect	0.92367975
67	MP0002837_dystrophic_cardiac_calcinosis	0.91732493
68	MP0003315_abnormal_perineum_morphology	0.89732392
69	MP0002166_altered_tumor_susceptibility	0.88828049
70	MP0005332_abnormal_amino_acid	0.88278164
71	MP0002751_abnormal_autonomic_nervous	0.87710088
72	MP0001984_abnormal_olfaction	0.86073995
73	MP0000566_synostosis	0.81236947
74	MP0002139_abnormal_hepatobiliary_system	0.81031500
75	MP0005365_abnormal_bile_salt	0.80000626
76	MP0003937_abnormal_limbs/digits/tail_de	0.79201420
77	MP0000569_abnormal_digit_pigmentation	0.78631506
78	MP0005381_digestive/alimentary_phenotyp	0.77026430
79	MP0005671_abnormal_response_to	0.73901298
80	MP0005499_abnormal_olfactory_system	0.73900180
81	MP0005394_taste/olfaction_phenotype	0.73900180
82	MP0005670_abnormal_white_adipose	0.73804105
83	MP0004147_increased_porphyrin_level	0.72548857
84	MP0001905_abnormal_dopamine_level	0.72069519
85	MP0005386_behavior/neurological_phenoty	0.70425970
86	MP0004924_abnormal_behavior	0.70425970
87	MP0005391_vision/eye_phenotype	0.69111053
88	MP0006035_abnormal_mitochondrial_morpho	0.68934593
89	MP0002572_abnormal_emotion/affect_behav	0.68481579
90	MP0003633_abnormal_nervous_system	0.66971900
91	MP0003221_abnormal_cardiomyocyte_apopto	0.64993437
92	MP0002282_abnormal_trachea_morphology	0.64927473
93	MP0001873_stomach_inflammation	0.63575842
94	MP0003786_premature_aging	0.61604044
95	MP0002693_abnormal_pancreas_physiology	0.60062107
96	MP0005195_abnormal_posterior_eye	0.59392286
97	MP0001666_abnormal_nutrient_absorption	0.59006297
98	MP0009764_decreased_sensitivity_to	0.58373792
99	MP0002909_abnormal_adrenal_gland	0.57117353
100	MP0002069_abnormal_eating/drinking_beha	0.56937816

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypomagnesemia (HP:0002917)	4.51961429
2	Delayed CNS myelination (HP:0002188)	4.35692847
3	Abnormality of the prostate (HP:0008775)	4.24309666
4	Acute necrotizing encephalopathy (HP:0006965)	3.95531247
5	Acute encephalopathy (HP:0006846)	3.77074400
6	Prostate neoplasm (HP:0100787)	3.62554299
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.62444637
8	Abnormality of magnesium homeostasis (HP:0004921)	3.55678584
9	Progressive macrocephaly (HP:0004481)	3.43935192
10	Molar tooth sign on MRI (HP:0002419)	3.24340088
11	Abnormality of midbrain morphology (HP:0002418)	3.24340088
12	Progressive inability to walk (HP:0002505)	3.04881308
13	Supernumerary spleens (HP:0009799)	2.99465866
14	Short 1st metacarpal (HP:0010034)	2.99301022
15	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.99301022
16	Increased serum lactate (HP:0002151)	2.92057670
17	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.87884015
18	Cerebral edema (HP:0002181)	2.87699921
19	Mitochondrial inheritance (HP:0001427)	2.87551664
20	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.84522628
21	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.84522628
22	Abolished electroretinogram (ERG) (HP:0000550)	2.84044323
23	Type 2 muscle fiber atrophy (HP:0003554)	2.74478953
24	Urethral obstruction (HP:0000796)	2.74020810
25	Abnormality of the 1st metacarpal (HP:0010009)	2.66412227
26	Increased CSF lactate (HP:0002490)	2.57028996
27	Hepatocellular necrosis (HP:0001404)	2.56184017
28	Lactic acidosis (HP:0003128)	2.53006705
29	Generalized aminoaciduria (HP:0002909)	2.48120237
30	Volvulus (HP:0002580)	2.44645111
31	Abnormality of male internal genitalia (HP:0000022)	2.44312102
32	Methylmalonic acidemia (HP:0002912)	2.39286205
33	Hepatic necrosis (HP:0002605)	2.38797803
34	Polyuria (HP:0000103)	2.36079000
35	Optic disc pallor (HP:0000543)	2.33491993
36	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.30830112
37	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.27993048
38	Asplenia (HP:0001746)	2.26732960
39	Retinal dysplasia (HP:0007973)	2.26095575
40	Absent epiphyses (HP:0010577)	2.25761280
41	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.25761280
42	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.25088290
43	Thyroid-stimulating hormone excess (HP:0002925)	2.24383430
44	Medial flaring of the eyebrow (HP:0010747)	2.23318938
45	3-Methylglutaconic aciduria (HP:0003535)	2.21990845
46	Limb hypertonia (HP:0002509)	2.21495171
47	Short phalanx of the thumb (HP:0009660)	2.19822911
48	Pancreatic cysts (HP:0001737)	2.19660960
49	True hermaphroditism (HP:0010459)	2.19511505
50	J-shaped sella turcica (HP:0002680)	2.19355027
51	Renal salt wasting (HP:0000127)	2.17501244
52	Abnormality of alanine metabolism (HP:0010916)	2.17022556
53	Hyperalaninemia (HP:0003348)	2.17022556
54	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.17022556
55	Hypothermia (HP:0002045)	2.15646084
56	Nephronophthisis (HP:0000090)	2.15395374
57	Cellular immunodeficiency (HP:0005374)	2.14844764
58	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.13702538
59	Hypoplasia of the fovea (HP:0007750)	2.13231614
60	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.13231614
61	Short tibia (HP:0005736)	2.10845768
62	Muscle fiber atrophy (HP:0100295)	2.10303302
63	Abnormality of the renal medulla (HP:0100957)	2.09572566
64	Hydroureter (HP:0000072)	2.09126095
65	Increased hepatocellular lipid droplets (HP:0006565)	2.05768325
66	Xerostomia (HP:0000217)	2.00567042
67	Chronic mucocutaneous candidiasis (HP:0002728)	1.98911613
68	Recurrent cutaneous fungal infections (HP:0011370)	1.98911613
69	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.95823715
70	Increased intramyocellular lipid droplets (HP:0012240)	1.92472160
71	Abnormality of the fovea (HP:0000493)	1.91563618
72	Abnormal urine output (HP:0012590)	1.91561065
73	Dyschromatopsia (HP:0007641)	1.90978474
74	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.90823627
75	Short hallux (HP:0010109)	1.90206981
76	Lipid accumulation in hepatocytes (HP:0006561)	1.90169758
77	Delayed myelination (HP:0012448)	1.89764210
78	Inability to walk (HP:0002540)	1.88758583
79	Colon cancer (HP:0003003)	1.88558096
80	Abnormality of the renal cortex (HP:0011035)	1.86654219
81	Methylmalonic aciduria (HP:0012120)	1.86048133
82	Hypoproteinemia (HP:0003075)	1.85795209
83	Broad-based gait (HP:0002136)	1.84164062
84	Abnormality of the pons (HP:0007361)	1.83527280
85	Hyperglycinemia (HP:0002154)	1.82839318
86	Respiratory failure (HP:0002878)	1.82680912
87	Ureteral stenosis (HP:0000071)	1.82371624
88	Attenuation of retinal blood vessels (HP:0007843)	1.82268707
89	Aplasia/hypoplasia of the uterus (HP:0008684)	1.80635476
90	Alkalosis (HP:0001948)	1.78322926
91	Exercise intolerance (HP:0003546)	1.78127257
92	Abnormal number of erythroid precursors (HP:0012131)	1.77425596
93	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.77145994
94	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.77145994
95	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.73993446
96	Tubulointerstitial abnormality (HP:0001969)	1.73924882
97	Leukodystrophy (HP:0002415)	1.73052878
98	Palpitations (HP:0001962)	1.71166684
99	Pancreatic fibrosis (HP:0100732)	1.71060538
100	Tubulointerstitial nephritis (HP:0001970)	1.70667262

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	6.47733775
2	PINK1	3.47433326
3	TLK1	3.40056747
4	ADRBK2	3.12157697
5	ZAK	2.96681127
6	VRK2	2.80545017
7	KIT	2.43266432
8	TRIM28	2.19871597
9	TAF1	2.16760231
10	MKNK1	2.14003270
11	BCKDK	2.01361522
12	VRK1	1.96948223
13	MAP3K4	1.95927179
14	WNK3	1.83666580
15	BCR	1.82570670
16	NUAK1	1.80093154
17	CSNK1G3	1.74546743
18	RPS6KA4	1.58967155
19	FER	1.58267416
20	CSNK1G2	1.57504415
21	SRPK1	1.54474518
22	GRK1	1.44815464
23	CSNK1G1	1.41968352
24	CSNK1A1L	1.40585339
25	MAP2K7	1.32663406
26	PLK3	1.25762810
27	KDR	1.22652695
28	FRK	1.19311386
29	PLK2	1.17153664
30	TXK	1.16011954
31	EIF2AK1	1.10129603
32	BRSK2	1.08741863
33	CDK8	1.06460419
34	CAMKK2	1.04012269
35	TSSK6	1.03551412
36	ERBB3	1.02835641
37	EIF2AK3	1.01706221
38	TIE1	0.99962001
39	INSRR	0.99464870
40	PHKG2	0.93153203
41	PHKG1	0.93153203
42	RPS6KA5	0.91635007
43	BMPR1B	0.90780121
44	MAPKAPK5	0.88243291
45	CDK3	0.85154444
46	ADRBK1	0.84817574
47	SCYL2	0.84358780
48	PLK4	0.82760917
49	IRAK2	0.81847954
50	DYRK2	0.81265259
51	BUB1	0.79987099
52	CLK1	0.73937289
53	MINK1	0.70601994
54	PRKCE	0.70577190
55	CDC7	0.70397060
56	WNK4	0.69107726
57	CASK	0.68050799
58	EPHA4	0.67518825
59	NEK1	0.66945759
60	CDK19	0.65433360
61	SIK3	0.65092894
62	MAPK13	0.60992325
63	CSNK1A1	0.60465029
64	GRK5	0.59562445
65	CSF1R	0.58564488
66	TAOK3	0.57975528
67	SYK	0.57626084
68	TYRO3	0.57025406
69	CDK9	0.53741356
70	TNK2	0.52837472
71	MST4	0.52292827
72	CAMKK1	0.51725073
73	IKBKE	0.51303605
74	EPHB2	0.51008158
75	DAPK1	0.50911914
76	CAMK2A	0.50814770
77	PLK1	0.50055878
78	FLT3	0.49891701
79	CHEK2	0.49773547
80	CCNB1	0.48368907
81	TYK2	0.48345856
82	PRKCG	0.46695068
83	AURKB	0.44946214
84	ATR	0.43967673
85	MKNK2	0.42072370
86	JAK3	0.41986889
87	LYN	0.38732053
88	CDK18	0.38663913
89	PBK	0.38543077
90	CSNK2A1	0.35028761
91	EPHB1	0.34141703
92	EIF2AK2	0.33592773
93	TEC	0.33071267
94	CDK15	0.31782433
95	ERBB4	0.31057363
96	PRKACA	0.30542130
97	PRKCA	0.28445252
98	CDK11A	0.28111683
99	CDK14	0.28011152
100	NME1	0.27903576

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.35001779
2	Proteasome_Homo sapiens_hsa03050	3.19197454
3	Allograft rejection_Homo sapiens_hsa05330	3.13091867
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.12530159
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.94580297
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.78499380
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.73149559
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.26941771
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.12790415
10	Parkinsons disease_Homo sapiens_hsa05012	2.07815201
11	Protein export_Homo sapiens_hsa03060	2.02115317
12	Mismatch repair_Homo sapiens_hsa03430	1.99474422
13	Propanoate metabolism_Homo sapiens_hsa00640	1.94104521
14	Antigen processing and presentation_Homo sapiens_hsa04612	1.87438083
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.73955889
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.73506433
17	RNA polymerase_Homo sapiens_hsa03020	1.72798355
18	DNA replication_Homo sapiens_hsa03030	1.68618854
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.65125466
20	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.53527731
21	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.53209780
22	Pyruvate metabolism_Homo sapiens_hsa00620	1.50246113
23	RNA degradation_Homo sapiens_hsa03018	1.50104571
24	Rheumatoid arthritis_Homo sapiens_hsa05323	1.47946199
25	Sulfur metabolism_Homo sapiens_hsa00920	1.46296631
26	Viral myocarditis_Homo sapiens_hsa05416	1.42947183
27	Basal transcription factors_Homo sapiens_hsa03022	1.42008723
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.40267711
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.35834753
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.31974388
31	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.30265618
32	Base excision repair_Homo sapiens_hsa03410	1.27810928
33	Huntingtons disease_Homo sapiens_hsa05016	1.24031527
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.13624740
35	Phototransduction_Homo sapiens_hsa04744	1.12268880
36	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.11573500
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.06582844
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.05156640
39	Spliceosome_Homo sapiens_hsa03040	1.04400727
40	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.02395438
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.01972958
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01322587
43	Steroid biosynthesis_Homo sapiens_hsa00100	0.98689335
44	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.97782069
45	Taste transduction_Homo sapiens_hsa04742	0.96068203
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.95533029
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95505383
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.94728928
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.91444389
50	Alzheimers disease_Homo sapiens_hsa05010	0.90528336
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90010627
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89715398
53	RNA transport_Homo sapiens_hsa03013	0.89459552
54	Fatty acid elongation_Homo sapiens_hsa00062	0.88661272
55	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.87473536
56	Ribosome_Homo sapiens_hsa03010	0.85348864
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84762853
58	Nicotine addiction_Homo sapiens_hsa05033	0.83391940
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.80650275
60	Purine metabolism_Homo sapiens_hsa00230	0.79512723
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.77798679
62	Folate biosynthesis_Homo sapiens_hsa00790	0.76152025
63	Leishmaniasis_Homo sapiens_hsa05140	0.73760197
64	Regulation of autophagy_Homo sapiens_hsa04140	0.72285800
65	Butanoate metabolism_Homo sapiens_hsa00650	0.71101281
66	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.70895226
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67332927
68	Cardiac muscle contraction_Homo sapiens_hsa04260	0.66720237
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65084976
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.63832809
71	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.60038029
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.60006556
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58792527
74	Retinol metabolism_Homo sapiens_hsa00830	0.57884966
75	Metabolic pathways_Homo sapiens_hsa01100	0.55467270
76	Caffeine metabolism_Homo sapiens_hsa00232	0.55242377
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54013321
78	Homologous recombination_Homo sapiens_hsa03440	0.52976639
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48077040
80	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.47301153
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46334282
82	Morphine addiction_Homo sapiens_hsa05032	0.46143606
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45701550
84	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.45451278
85	Phagosome_Homo sapiens_hsa04145	0.44173123
86	Salivary secretion_Homo sapiens_hsa04970	0.43390090
87	Herpes simplex infection_Homo sapiens_hsa05168	0.43113483
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41804915
89	GABAergic synapse_Homo sapiens_hsa04727	0.40303001
90	Olfactory transduction_Homo sapiens_hsa04740	0.39940506
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38847347
92	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37877064
93	Sulfur relay system_Homo sapiens_hsa04122	0.37727752
94	Chemical carcinogenesis_Homo sapiens_hsa05204	0.36799751
95	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.34241939
96	Peroxisome_Homo sapiens_hsa04146	0.28268010
97	Fatty acid degradation_Homo sapiens_hsa00071	0.27626212
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.26976469
99	Carbon metabolism_Homo sapiens_hsa01200	0.25975185
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.25644781

RBMXP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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