ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	7.89905484
2	cytidine metabolic process (GO:0046087)	5.48744009
3	cytidine catabolic process (GO:0006216)	5.48744009
4	cytidine deamination (GO:0009972)	5.48744009
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.03855615
6	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.49747430
7	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.49747430
8	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.48515389
9	behavioral response to nicotine (GO:0035095)	4.03894315
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.78642469
11	regulation of cellular amino acid metabolic process (GO:0006521)	3.74237703
12	protein neddylation (GO:0045116)	3.70909589
13	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.68928885
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.62941189
15	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.61466370
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.59052669
17	ATP synthesis coupled proton transport (GO:0015986)	3.59052669
18	aggressive behavior (GO:0002118)	3.57374208
19	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.54658997
20	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.54658997
21	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.54658997
22	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.49463355
23	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.49463355
24	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.47008211
25	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.44699669
26	proteasome assembly (GO:0043248)	3.43875510
27	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.37889436
28	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.37889436
29	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.37272755
30	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.33592515
31	rRNA modification (GO:0000154)	3.32149936
32	S-adenosylmethionine metabolic process (GO:0046500)	3.30076237
33	respiratory chain complex IV assembly (GO:0008535)	3.29520467
34	kynurenine metabolic process (GO:0070189)	3.25742153
35	iron-sulfur cluster assembly (GO:0016226)	3.21436030
36	metallo-sulfur cluster assembly (GO:0031163)	3.21436030
37	negative regulation of ligase activity (GO:0051352)	3.21204237
38	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.21204237
39	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.19759006
40	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.17827655
41	positive thymic T cell selection (GO:0045059)	3.07839417
42	L-fucose catabolic process (GO:0042355)	3.03674247
43	fucose catabolic process (GO:0019317)	3.03674247
44	L-fucose metabolic process (GO:0042354)	3.03674247
45	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.99714035
46	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.99347763
47	electron transport chain (GO:0022900)	2.98368378
48	tryptophan catabolic process (GO:0006569)	2.97604639
49	indole-containing compound catabolic process (GO:0042436)	2.97604639
50	indolalkylamine catabolic process (GO:0046218)	2.97604639
51	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.95864614
52	cytochrome complex assembly (GO:0017004)	2.89396394
53	respiratory electron transport chain (GO:0022904)	2.87916976
54	negative regulation by host of viral transcription (GO:0043922)	2.87664550
55	rRNA methylation (GO:0031167)	2.84413600
56	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.84029656
57	tryptophan metabolic process (GO:0006568)	2.81872346
58	GPI anchor metabolic process (GO:0006505)	2.81195538
59	positive regulation of ligase activity (GO:0051351)	2.79973009
60	protein complex biogenesis (GO:0070271)	2.78909241
61	positive regulation of defense response to virus by host (GO:0002230)	2.77542855
62	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.76121283
63	mannosylation (GO:0097502)	2.73533289
64	positive regulation of cell cycle arrest (GO:0071158)	2.73083144
65	regulation of cellular amine metabolic process (GO:0033238)	2.73000768
66	positive regulation of prostaglandin secretion (GO:0032308)	2.71777859
67	piRNA metabolic process (GO:0034587)	2.70269468
68	GPI anchor biosynthetic process (GO:0006506)	2.68950899
69	response to pheromone (GO:0019236)	2.68740507
70	immunoglobulin mediated immune response (GO:0016064)	2.66944997
71	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.65224005
72	regulation of interleukin-8 secretion (GO:2000482)	2.64891479
73	platelet dense granule organization (GO:0060155)	2.64397225
74	sulfation (GO:0051923)	2.64301079
75	pyrimidine nucleoside catabolic process (GO:0046135)	2.64109197
76	mitochondrial respiratory chain complex assembly (GO:0033108)	2.62035231
77	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.60606364
78	cullin deneddylation (GO:0010388)	2.58905331
79	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.57529633
80	termination of RNA polymerase III transcription (GO:0006386)	2.57529633
81	B cell mediated immunity (GO:0019724)	2.55713748
82	negative regulation of mast cell activation (GO:0033004)	2.54596306
83	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.53437677
84	indolalkylamine metabolic process (GO:0006586)	2.52617316
85	positive regulation of monocyte chemotaxis (GO:0090026)	2.50002656
86	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.48285387
87	protein deneddylation (GO:0000338)	2.43940603
88	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.40250758
89	positive regulation of fatty acid transport (GO:2000193)	2.40064157
90	positive regulation of interleukin-8 secretion (GO:2000484)	2.39457773
91	tRNA processing (GO:0008033)	2.39340842
92	peptidyl-histidine modification (GO:0018202)	2.37207464
93	pseudouridine synthesis (GO:0001522)	2.36608231
94	negative regulation of T cell apoptotic process (GO:0070233)	2.35503099
95	positive regulation of calcium-mediated signaling (GO:0050850)	2.34615588
96	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.33906942
97	regulation of cell cycle arrest (GO:0071156)	2.33680058
98	rRNA catabolic process (GO:0016075)	2.32463680
99	proton transport (GO:0015992)	2.32353930
100	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.31713523

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.27510784
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.88596471
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.80598603
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.54533734
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.38609606
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.09556104
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.97854823
8	VDR_22108803_ChIP-Seq_LS180_Human	2.92235885
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.87910547
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.84140852
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.81488377
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.76009427
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.73263152
14	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.46203686
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.45828256
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.40370054
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.32409977
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.30103390
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.26338888
20	IGF1R_20145208_ChIP-Seq_DFB_Human	2.19977658
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.19719777
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.15863281
23	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.13490685
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12265088
25	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.09102816
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.02092841
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.97559316
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.78186942
29	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.78026610
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73256504
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.70362629
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.66146461
33	GATA3_26560356_Chip-Seq_TH2_Human	1.62457447
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.59433177
35	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.59421945
36	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.52648108
37	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.49598791
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.49500675
39	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.48100010
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46798234
41	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.45587209
42	AR_20517297_ChIP-Seq_VCAP_Human	1.45023000
43	EWS_26573619_Chip-Seq_HEK293_Human	1.41825056
44	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.34551894
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31162898
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31162898
47	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.29049693
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.25585954
49	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.25206762
50	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24867783
51	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.23976244
52	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.23027202
53	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.22693647
54	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22474948
55	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.22464705
56	NCOR_22424771_ChIP-Seq_293T_Human	1.22122518
57	FUS_26573619_Chip-Seq_HEK293_Human	1.21349666
58	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.20460581
59	MYB_26560356_Chip-Seq_TH2_Human	1.20326302
60	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19072547
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18245928
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18245928
63	TAF15_26573619_Chip-Seq_HEK293_Human	1.17656725
64	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.16031312
65	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.15397359
66	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.13093610
67	GABP_19822575_ChIP-Seq_HepG2_Human	1.11823438
68	GATA3_27048872_Chip-Seq_THYMUS_Human	1.08763126
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07457887
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06452031
71	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05792989
72	TAF2_19829295_ChIP-Seq_ESCs_Human	1.05440318
73	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04704351
74	CBP_20019798_ChIP-Seq_JUKART_Human	1.04322626
75	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.04322626
76	ER_23166858_ChIP-Seq_MCF-7_Human	1.04024805
77	CIITA_25753668_ChIP-Seq_RAJI_Human	1.03653777
78	GATA3_26560356_Chip-Seq_TH1_Human	1.03358338
79	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02836479
80	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.02646461
81	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.02490780
82	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02360559
83	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00398198
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99726072
85	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99199980
86	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.98775445
87	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98638442
88	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.98365325
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98069955
90	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98020595
91	DCP1A_22483619_ChIP-Seq_HELA_Human	0.97687555
92	P300_19829295_ChIP-Seq_ESCs_Human	0.96934042
93	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.96766456
94	ERA_21632823_ChIP-Seq_H3396_Human	0.96128738
95	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.95807433
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95512306
97	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.95340942
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.95198860
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94420423
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.92491538

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.60233076
2	MP0003806_abnormal_nucleotide_metabolis	3.50877485
3	MP0000372_irregular_coat_pigmentation	3.02867507
4	MP0005084_abnormal_gallbladder_morpholo	2.91941270
5	MP0002138_abnormal_hepatobiliary_system	2.82843646
6	MP0002102_abnormal_ear_morphology	2.64987403
7	MP0005646_abnormal_pituitary_gland	2.42518163
8	MP0008875_abnormal_xenobiotic_pharmacok	2.36623266
9	MP0008872_abnormal_physiological_respon	2.33427363
10	MP0001835_abnormal_antigen_presentation	2.31733279
11	MP0008058_abnormal_DNA_repair	2.13643357
12	MP0002148_abnormal_hypersensitivity_rea	2.10653088
13	MP0002163_abnormal_gland_morphology	2.08050621
14	MP0006072_abnormal_retinal_apoptosis	1.93066059
15	MP0005075_abnormal_melanosome_morpholog	1.91457095
16	MP0003011_delayed_dark_adaptation	1.87251882
17	MP0009785_altered_susceptibility_to	1.85116988
18	MP0001800_abnormal_humoral_immune	1.67647774
19	MP0005551_abnormal_eye_electrophysiolog	1.65201695
20	MP0006036_abnormal_mitochondrial_physio	1.64284170
21	MP0003866_abnormal_defecation	1.63799997
22	MP0003693_abnormal_embryo_hatching	1.62083052
23	MP0004145_abnormal_muscle_electrophysio	1.58316452
24	MP0004043_abnormal_pH_regulation	1.57564142
25	MP0003880_abnormal_central_pattern	1.53631304
26	MP0005000_abnormal_immune_tolerance	1.52589200
27	MP0006082_CNS_inflammation	1.51199595
28	MP0005085_abnormal_gallbladder_physiolo	1.47454514
29	MP0001968_abnormal_touch/_nociception	1.46437635
30	MP0005410_abnormal_fertilization	1.44133796
31	MP0001986_abnormal_taste_sensitivity	1.43988378
32	MP0008995_early_reproductive_senescence	1.43578928
33	MP0003195_calcinosis	1.42041924
34	MP0006276_abnormal_autonomic_nervous	1.40365444
35	MP0002723_abnormal_immune_serum	1.39984366
36	MP0010094_abnormal_chromosome_stability	1.39371907
37	MP0003718_maternal_effect	1.39218656
38	MP0010386_abnormal_urinary_bladder	1.36181328
39	MP0002452_abnormal_antigen_presenting	1.33366231
40	MP0005253_abnormal_eye_physiology	1.32262054
41	MP0003786_premature_aging	1.31319810
42	MP0005645_abnormal_hypothalamus_physiol	1.29921003
43	MP0005332_abnormal_amino_acid	1.29236714
44	MP0002006_tumorigenesis	1.28031969
45	MP0001819_abnormal_immune_cell	1.27802704
46	MP0002277_abnormal_respiratory_mucosa	1.27606198
47	MP0003724_increased_susceptibility_to	1.27303748
48	MP0002166_altered_tumor_susceptibility	1.27136820
49	MP0002420_abnormal_adaptive_immunity	1.26367423
50	MP0002876_abnormal_thyroid_physiology	1.19143679
51	MP0001764_abnormal_homeostasis	1.18197386
52	MP0006035_abnormal_mitochondrial_morpho	1.17611553
53	MP0001790_abnormal_immune_system	1.16677488
54	MP0005387_immune_system_phenotype	1.16677488
55	MP0005025_abnormal_response_to	1.15162947
56	MP0000685_abnormal_immune_system	1.13592344
57	MP0005379_endocrine/exocrine_gland_phen	1.12018939
58	MP0004147_increased_porphyrin_level	1.09142026
59	MP0003646_muscle_fatigue	1.08610227
60	MP0010155_abnormal_intestine_physiology	1.07754606
61	MP0006292_abnormal_olfactory_placode	1.07530744
62	MP0001873_stomach_inflammation	1.07379815
63	MP0009333_abnormal_splenocyte_physiolog	1.07367469
64	MP0005389_reproductive_system_phenotype	1.06554846
65	MP0005377_hearing/vestibular/ear_phenot	1.06401625
66	MP0003878_abnormal_ear_physiology	1.06401625
67	MP0008877_abnormal_DNA_methylation	1.01118375
68	MP0005360_urolithiasis	1.00766840
69	MP0002160_abnormal_reproductive_system	0.99578957
70	MP0003763_abnormal_thymus_physiology	0.98337382
71	MP0002139_abnormal_hepatobiliary_system	0.96119985
72	MP0003183_abnormal_peptide_metabolism	0.96003384
73	MP0001845_abnormal_inflammatory_respons	0.93955658
74	MP0000716_abnormal_immune_system	0.93295699
75	MP0008469_abnormal_protein_level	0.93284414
76	MP0002736_abnormal_nociception_after	0.93190643
77	MP0002095_abnormal_skin_pigmentation	0.92999062
78	MP0000689_abnormal_spleen_morphology	0.89733841
79	MP0002398_abnormal_bone_marrow	0.87851440
80	MP0002733_abnormal_thermal_nociception	0.87380329
81	MP0009764_decreased_sensitivity_to	0.86585149
82	MP0005636_abnormal_mineral_homeostasis	0.86447116
83	MP0001970_abnormal_pain_threshold	0.85912907
84	MP0001905_abnormal_dopamine_level	0.84759358
85	MP0001919_abnormal_reproductive_system	0.84534355
86	MP0010329_abnormal_lipoprotein_level	0.83857491
87	MP0002396_abnormal_hematopoietic_system	0.82328316
88	MP0009643_abnormal_urine_homeostasis	0.82311256
89	MP0001666_abnormal_nutrient_absorption	0.80471504
90	MP0001929_abnormal_gametogenesis	0.78188047
91	MP0005670_abnormal_white_adipose	0.75783826
92	MP0005464_abnormal_platelet_physiology	0.75763640
93	MP0002272_abnormal_nervous_system	0.74731519
94	MP0009745_abnormal_behavioral_response	0.74688232
95	MP0000230_abnormal_systemic_arterial	0.74497968
96	MP0005167_abnormal_blood-brain_barrier	0.74281190
97	MP0003137_abnormal_impulse_conducting	0.73031456
98	MP0002429_abnormal_blood_cell	0.72697174
99	MP0002735_abnormal_chemical_nociception	0.72043601
100	MP0002933_joint_inflammation	0.70331334

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoproteinemia (HP:0003075)	4.07934880
2	Acute necrotizing encephalopathy (HP:0006965)	3.67875722
3	Mitochondrial inheritance (HP:0001427)	3.64263759
4	Hepatocellular necrosis (HP:0001404)	3.58596318
5	Increased CSF lactate (HP:0002490)	3.57900048
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.52401691
7	Abolished electroretinogram (ERG) (HP:0000550)	3.48662067
8	Pancreatic cysts (HP:0001737)	3.43638122
9	Acute encephalopathy (HP:0006846)	3.34346215
10	Hepatic necrosis (HP:0002605)	3.29440286
11	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.21363119
12	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.21363119
13	Progressive macrocephaly (HP:0004481)	3.13781101
14	Pancreatic fibrosis (HP:0100732)	3.12428065
15	Increased intramyocellular lipid droplets (HP:0012240)	3.10859190
16	Aplastic anemia (HP:0001915)	3.09525789
17	3-Methylglutaconic aciduria (HP:0003535)	3.07749923
18	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.04814883
19	True hermaphroditism (HP:0010459)	3.01894190
20	Abnormality of the prostate (HP:0008775)	2.96380913
21	Abnormality of midbrain morphology (HP:0002418)	2.84088174
22	Molar tooth sign on MRI (HP:0002419)	2.84088174
23	Increased serum lactate (HP:0002151)	2.74767264
24	Attenuation of retinal blood vessels (HP:0007843)	2.73137086
25	IgG deficiency (HP:0004315)	2.72965567
26	Increased hepatocellular lipid droplets (HP:0006565)	2.70305845
27	Type 2 muscle fiber atrophy (HP:0003554)	2.69821700
28	Abnormality of alanine metabolism (HP:0010916)	2.67865693
29	Hyperalaninemia (HP:0003348)	2.67865693
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.67865693
31	Type I transferrin isoform profile (HP:0003642)	2.60465238
32	Increased muscle lipid content (HP:0009058)	2.55054953
33	J-shaped sella turcica (HP:0002680)	2.50701717
34	Abnormality of the pons (HP:0007361)	2.50399253
35	Lipid accumulation in hepatocytes (HP:0006561)	2.49899642
36	Lactic acidosis (HP:0003128)	2.48497150
37	Congenital stationary night blindness (HP:0007642)	2.46114140
38	Panhypogammaglobulinemia (HP:0003139)	2.46045921
39	Generalized aminoaciduria (HP:0002909)	2.42729991
40	Carpal bone hypoplasia (HP:0001498)	2.41885782
41	Hypoplasia of the pons (HP:0012110)	2.40232853
42	Abnormality of T cell number (HP:0011839)	2.36623386
43	Reduced antithrombin III activity (HP:0001976)	2.36199458
44	Decreased central vision (HP:0007663)	2.35118998
45	Cerebral edema (HP:0002181)	2.34803315
46	T lymphocytopenia (HP:0005403)	2.31869002
47	Renal Fanconi syndrome (HP:0001994)	2.30925031
48	Optic disc pallor (HP:0000543)	2.30420202
49	Pendular nystagmus (HP:0012043)	2.25948521
50	Oral leukoplakia (HP:0002745)	2.25373170
51	Gaze-evoked nystagmus (HP:0000640)	2.23917188
52	Muscle fiber atrophy (HP:0100295)	2.21829707
53	Nephronophthisis (HP:0000090)	2.20275237
54	Severe combined immunodeficiency (HP:0004430)	2.19310439
55	Abnormality of the renal cortex (HP:0011035)	2.17802998
56	Methylmalonic acidemia (HP:0002912)	2.17089210
57	Abnormal biliary tract physiology (HP:0012439)	2.13911338
58	Bile duct proliferation (HP:0001408)	2.13911338
59	Dyschromatopsia (HP:0007641)	2.07630541
60	Renal cortical cysts (HP:0000803)	2.03942159
61	Lethargy (HP:0001254)	2.03478222
62	Cerebral palsy (HP:0100021)	2.03392798
63	Meckel diverticulum (HP:0002245)	2.03299528
64	Respiratory failure (HP:0002878)	2.02844338
65	Delayed CNS myelination (HP:0002188)	2.02840985
66	Abnormality of the ileum (HP:0001549)	2.01370534
67	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.99465406
68	Abnormal protein N-linked glycosylation (HP:0012347)	1.99465406
69	Abnormal protein glycosylation (HP:0012346)	1.99465406
70	Abnormal glycosylation (HP:0012345)	1.99465406
71	Hypothermia (HP:0002045)	1.96193489
72	Hypoalbuminemia (HP:0003073)	1.96107152
73	Abnormal albumin level (HP:0012116)	1.96107152
74	Opisthotonus (HP:0002179)	1.95297550
75	Thyroiditis (HP:0100646)	1.95183597
76	Abnormality of B cell number (HP:0010975)	1.95153792
77	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.94990540
78	Hypoplasia of the fovea (HP:0007750)	1.94990540
79	Exertional dyspnea (HP:0002875)	1.94364630
80	Exercise intolerance (HP:0003546)	1.94305002
81	Hyperglycinuria (HP:0003108)	1.94110771
82	Methylmalonic aciduria (HP:0012120)	1.90143934
83	Autoimmune hemolytic anemia (HP:0001890)	1.90078832
84	Cystic liver disease (HP:0006706)	1.88876507
85	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.87205379
86	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.83587677
87	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.83326701
88	Abnormality of T cells (HP:0002843)	1.81320929
89	CNS demyelination (HP:0007305)	1.80914449
90	Abnormality of the renal medulla (HP:0100957)	1.80640173
91	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.80558369
92	Increased corneal curvature (HP:0100692)	1.80179167
93	Keratoconus (HP:0000563)	1.80179167
94	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79750931
95	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.78629119
96	Stomach cancer (HP:0012126)	1.78516094
97	Sclerocornea (HP:0000647)	1.76784483
98	Abnormality of eosinophils (HP:0001879)	1.76500404
99	Cleft eyelid (HP:0000625)	1.76365549
100	Medial flaring of the eyebrow (HP:0010747)	1.75602567

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.40334030
2	TAOK3	3.38452310
3	ZAK	3.35607052
4	TLK1	3.26894621
5	TXK	3.17246417
6	NUAK1	3.09391224
7	VRK2	3.00980127
8	ADRBK2	2.79163241
9	KDR	2.40147461
10	MST4	2.24842955
11	STK16	2.18016221
12	BUB1	2.09449609
13	VRK1	2.08792925
14	MUSK	1.91170179
15	GRK1	1.85815509
16	FRK	1.71253864
17	MAP3K12	1.69852322
18	PINK1	1.67650135
19	EIF2AK3	1.64192898
20	BCKDK	1.60112580
21	TRIM28	1.52265438
22	DAPK1	1.41596605
23	ITK	1.41354313
24	KIT	1.37594899
25	SRPK1	1.34040699
26	TIE1	1.25884336
27	CDK19	1.24475642
28	BMPR2	1.21122829
29	TESK2	1.20192910
30	WNK4	1.11988108
31	FES	1.10942552
32	CAMKK2	1.08551762
33	SYK	1.08396317
34	CSNK1G3	1.07492867
35	MYLK	1.03233659
36	FLT3	0.99250422
37	PDK2	0.96125346
38	TNK2	0.95032349
39	PLK3	0.93180019
40	CSNK1A1L	0.92064746
41	BMPR1B	0.91884231
42	OXSR1	0.91540185
43	CSNK1G1	0.90220039
44	MAPKAPK3	0.89154489
45	NME1	0.89004121
46	CSNK1G2	0.86223872
47	TSSK6	0.86167279
48	PHKG2	0.84941117
49	PHKG1	0.84941117
50	EPHA4	0.84274535
51	TEC	0.83697622
52	WNK3	0.80744404
53	PRKCQ	0.80117271
54	CSF1R	0.78989039
55	TAF1	0.78876877
56	INSRR	0.78429368
57	MKNK1	0.78388984
58	IKBKE	0.77673932
59	IKBKB	0.75589871
60	PIK3CG	0.75275259
61	ERBB3	0.74952253
62	BRSK2	0.73314003
63	MAPKAPK5	0.73311861
64	DAPK2	0.71314896
65	TRPM7	0.67085702
66	LYN	0.64572892
67	MATK	0.62071408
68	GRK7	0.61826689
69	MAP4K1	0.61444305
70	PLK4	0.60605671
71	PIK3CA	0.59210729
72	JAK3	0.57694906
73	LCK	0.56947633
74	ADRBK1	0.56920376
75	MAPK13	0.56335985
76	CDK8	0.56302639
77	RPS6KA5	0.55444332
78	IRAK2	0.55306849
79	MAP2K6	0.55273311
80	BLK	0.55160562
81	ATR	0.54787645
82	MAP3K5	0.54628904
83	RIPK4	0.53921590
84	MAP3K4	0.52001697
85	AURKB	0.49642260
86	BTK	0.49534710
87	SCYL2	0.48407403
88	PLK2	0.47521155
89	TBK1	0.47107827
90	PLK1	0.45583534
91	DYRK2	0.43285080
92	DAPK3	0.41226059
93	CSNK1A1	0.38859948
94	EIF2AK2	0.37841104
95	IGF1R	0.37736520
96	CSNK2A1	0.35658183
97	OBSCN	0.35495367
98	PRKCE	0.35127877
99	GRK5	0.34464062
100	BCR	0.32215777

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.27911455
2	Asthma_Homo sapiens_hsa05310	3.49841154
3	Allograft rejection_Homo sapiens_hsa05330	3.37528672
4	Graft-versus-host disease_Homo sapiens_hsa05332	3.35805880
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.33727111
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.84797439
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.72503992
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.43735113
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.23077095
10	Antigen processing and presentation_Homo sapiens_hsa04612	2.04507310
11	Parkinsons disease_Homo sapiens_hsa05012	2.02670242
12	Homologous recombination_Homo sapiens_hsa03440	1.90037006
13	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.89018607
14	Rheumatoid arthritis_Homo sapiens_hsa05323	1.86393830
15	Non-homologous end-joining_Homo sapiens_hsa03450	1.84306938
16	Mismatch repair_Homo sapiens_hsa03430	1.77324704
17	RNA polymerase_Homo sapiens_hsa03020	1.73833422
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.68105122
19	One carbon pool by folate_Homo sapiens_hsa00670	1.58406676
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.53344701
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.47208976
22	Protein export_Homo sapiens_hsa03060	1.45922208
23	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.36886067
24	DNA replication_Homo sapiens_hsa03030	1.34775125
25	Phototransduction_Homo sapiens_hsa04744	1.32292829
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.31797488
27	Propanoate metabolism_Homo sapiens_hsa00640	1.31585169
28	RNA degradation_Homo sapiens_hsa03018	1.27966340
29	Viral myocarditis_Homo sapiens_hsa05416	1.27076739
30	Ribosome_Homo sapiens_hsa03010	1.23463260
31	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.15082429
32	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.10766302
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.09813597
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09585907
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.09062531
36	Peroxisome_Homo sapiens_hsa04146	1.08217373
37	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.07378456
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.05706942
39	Huntingtons disease_Homo sapiens_hsa05016	1.04865821
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.04398165
41	Basal transcription factors_Homo sapiens_hsa03022	1.01425994
42	Alzheimers disease_Homo sapiens_hsa05010	1.01343694
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.99361245
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.97200045
45	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.97001528
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.94931264
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92463231
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.92431010
49	Butanoate metabolism_Homo sapiens_hsa00650	0.92344329
50	RNA transport_Homo sapiens_hsa03013	0.86442649
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85885933
52	Retinol metabolism_Homo sapiens_hsa00830	0.85186117
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83063802
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82263137
55	Sulfur metabolism_Homo sapiens_hsa00920	0.81795871
56	Base excision repair_Homo sapiens_hsa03410	0.80205477
57	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.79262130
58	Regulation of autophagy_Homo sapiens_hsa04140	0.79108994
59	Pyruvate metabolism_Homo sapiens_hsa00620	0.76573896
60	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.75114805
61	Purine metabolism_Homo sapiens_hsa00230	0.73243729
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72682891
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72058869
64	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.72058311
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.71980762
66	Leishmaniasis_Homo sapiens_hsa05140	0.71171190
67	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.70450559
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68704574
69	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67148017
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66842216
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65251323
72	Spliceosome_Homo sapiens_hsa03040	0.65155169
73	Caffeine metabolism_Homo sapiens_hsa00232	0.63745822
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.63588900
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61653643
76	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.61298185
77	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.57924359
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56483702
79	Cardiac muscle contraction_Homo sapiens_hsa04260	0.56475893
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56102697
81	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.54182855
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47811556
83	Metabolic pathways_Homo sapiens_hsa01100	0.47434621
84	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46902013
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.44666516
86	Olfactory transduction_Homo sapiens_hsa04740	0.43772418
87	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.43218772
88	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.42917360
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.42883413
90	Fatty acid degradation_Homo sapiens_hsa00071	0.42691684
91	Herpes simplex infection_Homo sapiens_hsa05168	0.40409495
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.36785555
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35863028
94	Fatty acid elongation_Homo sapiens_hsa00062	0.35417914
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.31463390
96	Nicotine addiction_Homo sapiens_hsa05033	0.29283379
97	Taste transduction_Homo sapiens_hsa04742	0.27853357
98	Salivary secretion_Homo sapiens_hsa04970	0.27757743
99	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.24908260
100	Glutathione metabolism_Homo sapiens_hsa00480	0.22553616

RBMXP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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