RBMXP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.39974163
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.51977475
3protein neddylation (GO:0045116)6.07796064
4response to pheromone (GO:0019236)5.41335564
5cullin deneddylation (GO:0010388)5.33613421
6negative regulation by host of viral transcription (GO:0043922)5.27630076
7protein deneddylation (GO:0000338)4.87298824
8peptidyl-histidine modification (GO:0018202)4.67729071
9branched-chain amino acid catabolic process (GO:0009083)4.50058994
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.21327468
11negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.18459032
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.08921145
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.08921145
14gonadal mesoderm development (GO:0007506)3.85073839
15nonmotile primary cilium assembly (GO:0035058)3.76867325
16cytidine deamination (GO:0009972)3.73375028
17cytidine metabolic process (GO:0046087)3.73375028
18cytidine catabolic process (GO:0006216)3.73375028
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.72086133
20DNA strand renaturation (GO:0000733)3.68136111
21valine metabolic process (GO:0006573)3.62278149
22rRNA catabolic process (GO:0016075)3.49267083
23negative regulation of telomere maintenance (GO:0032205)3.48944428
24branched-chain amino acid metabolic process (GO:0009081)3.44205800
25intestinal cholesterol absorption (GO:0030299)3.43779176
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37904329
27ATP synthesis coupled proton transport (GO:0015986)3.37904329
28chaperone-mediated protein transport (GO:0072321)3.33262644
29behavioral response to nicotine (GO:0035095)3.31127915
30phosphorylated carbohydrate dephosphorylation (GO:0046838)3.29988579
31inositol phosphate dephosphorylation (GO:0046855)3.29988579
32terpenoid biosynthetic process (GO:0016114)3.27379145
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.27345750
34inner mitochondrial membrane organization (GO:0007007)3.25057018
35mitotic metaphase plate congression (GO:0007080)3.20688702
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.20173749
37NADH dehydrogenase complex assembly (GO:0010257)3.20173749
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20173749
39purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.20135309
403-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.20135309
41lateral ventricle development (GO:0021670)3.19150435
42regulation of cilium movement (GO:0003352)3.14406522
43DNA ligation (GO:0006266)3.06878990
44negative regulation of appetite (GO:0032099)3.06735409
45negative regulation of response to food (GO:0032096)3.06735409
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04720486
47negative regulation of DNA-templated transcription, elongation (GO:0032785)3.01479924
48phenol-containing compound catabolic process (GO:0019336)3.01478519
49protein complex biogenesis (GO:0070271)2.96817074
50RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.96162820
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94440215
52DNA double-strand break processing (GO:0000729)2.93520675
53L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88307186
54parturition (GO:0007567)2.85105521
55head development (GO:0060322)2.84118768
56double-strand break repair via homologous recombination (GO:0000724)2.82772588
57regulation of nuclear cell cycle DNA replication (GO:0033262)2.82143109
58inositol phosphate catabolic process (GO:0071545)2.79662063
59histone H2A acetylation (GO:0043968)2.79039787
60cellular response to leptin stimulus (GO:0044320)2.78590295
61modulation by host of viral transcription (GO:0043921)2.78565715
62modulation by host of symbiont transcription (GO:0052472)2.78565715
63recombinational repair (GO:0000725)2.77252230
64modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.75407221
65pyrimidine ribonucleoside catabolic process (GO:0046133)2.73737463
66somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.73457384
67isotype switching (GO:0045190)2.73457384
68somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.73457384
69RNA destabilization (GO:0050779)2.72136761
70maturation of 5.8S rRNA (GO:0000460)2.70599806
71mitochondrial respiratory chain complex assembly (GO:0033108)2.70501606
72RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.68309434
73water-soluble vitamin biosynthetic process (GO:0042364)2.66872588
74ovulation cycle (GO:0042698)2.65883946
75organelle disassembly (GO:1903008)2.65773575
76cornea development in camera-type eye (GO:0061303)2.64777430
77regulation of mesoderm development (GO:2000380)2.64425311
78negative regulation of actin filament bundle assembly (GO:0032232)2.62030647
79peptidyl-arginine omega-N-methylation (GO:0035247)2.61472195
80kinetochore assembly (GO:0051382)2.60621453
81aldehyde catabolic process (GO:0046185)2.60267516
82adenosine metabolic process (GO:0046085)2.59677780
83histone H4-K5 acetylation (GO:0043981)2.59416823
84histone H4-K8 acetylation (GO:0043982)2.59416823
85L-methionine salvage (GO:0071267)2.59100459
86L-methionine biosynthetic process (GO:0071265)2.59100459
87amino acid salvage (GO:0043102)2.59100459
88glyoxylate metabolic process (GO:0046487)2.58108666
89RNA phosphodiester bond hydrolysis (GO:0090501)2.55996816
90metaphase plate congression (GO:0051310)2.55958865
91negative regulation of epidermal cell differentiation (GO:0045605)2.53360704
92protein-cofactor linkage (GO:0018065)2.51956652
93DNA dealkylation (GO:0035510)2.48874473
94negative regulation of stress fiber assembly (GO:0051497)2.48279051
95DNA catabolic process, exonucleolytic (GO:0000738)2.47606662
96negative regulation of membrane potential (GO:0045837)2.43834642
97intra-S DNA damage checkpoint (GO:0031573)2.40387276
98chromatin remodeling at centromere (GO:0031055)2.38815665
99regulation of relaxation of muscle (GO:1901077)2.37434561
100CENP-A containing nucleosome assembly (GO:0034080)2.37182092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.71960882
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.62173228
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25759738
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.23422121
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11242378
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.02801847
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93131855
8ZNF274_21170338_ChIP-Seq_K562_Hela2.92037988
9VDR_22108803_ChIP-Seq_LS180_Human2.82220014
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.75159496
11EZH2_22144423_ChIP-Seq_EOC_Human2.46782163
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43274893
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35450623
14EWS_26573619_Chip-Seq_HEK293_Human2.25585541
15ER_23166858_ChIP-Seq_MCF-7_Human2.20390113
16FUS_26573619_Chip-Seq_HEK293_Human2.18250732
17ELK1_19687146_ChIP-ChIP_HELA_Human2.12645476
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05556684
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.00024323
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.99332450
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.79016011
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73252272
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.71165656
24IRF1_19129219_ChIP-ChIP_H3396_Human1.70256066
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66380620
26FOXP3_21729870_ChIP-Seq_TREG_Human1.66219303
27P300_19829295_ChIP-Seq_ESCs_Human1.60761112
28GBX2_23144817_ChIP-Seq_PC3_Human1.59977334
29TAF15_26573619_Chip-Seq_HEK293_Human1.59899380
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59130980
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56759159
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53737224
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53737224
34IGF1R_20145208_ChIP-Seq_DFB_Human1.50512310
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50407428
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50226644
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48816747
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47432646
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46582802
40BCAT_22108803_ChIP-Seq_LS180_Human1.44715083
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42315127
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.41999675
43HTT_18923047_ChIP-ChIP_STHdh_Human1.41887077
44VDR_23849224_ChIP-Seq_CD4+_Human1.40220446
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39718799
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37282982
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36211526
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.35808626
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32827168
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31956537
51TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.31609214
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30562045
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29036363
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.28578464
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27025965
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26044588
57CBP_20019798_ChIP-Seq_JUKART_Human1.26044588
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25596422
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24310051
60AR_20517297_ChIP-Seq_VCAP_Human1.23725616
61TP53_22573176_ChIP-Seq_HFKS_Human1.20574333
62SMAD4_21799915_ChIP-Seq_A2780_Human1.19656628
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18645301
64CDX2_22108803_ChIP-Seq_LS180_Human1.16914305
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13011775
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11595902
67SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.11525472
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11133631
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08567845
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08192243
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06153538
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.05871213
73RUNX2_22187159_ChIP-Seq_PCA_Human1.04726208
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04413323
75MYC_18940864_ChIP-ChIP_HL60_Human1.03166836
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02952017
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02584965
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.02130454
79P53_22387025_ChIP-Seq_ESCs_Mouse1.01829331
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.01786044
81TCF4_22108803_ChIP-Seq_LS180_Human1.00839008
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99380002
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99096215
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98743336
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97916402
86TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96667164
87HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96364476
88NANOG_18555785_Chip-Seq_ESCs_Mouse0.95632391
89P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95174529
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94592007
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94296447
92GATA3_21878914_ChIP-Seq_MCF-7_Human0.93302673
93P300_18555785_Chip-Seq_ESCs_Mouse0.93006600
94CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91913176
95TCF4_23295773_ChIP-Seq_U87_Human0.90630663
96MYC_19829295_ChIP-Seq_ESCs_Human0.90284403
97STAT3_23295773_ChIP-Seq_U87_Human0.88634567
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.88370955
99HOXB7_26014856_ChIP-Seq_BT474_Human0.87718250
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.87579870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after2.91121087
2MP0009697_abnormal_copulation2.76570995
3MP0001293_anophthalmia2.73057723
4MP0001968_abnormal_touch/_nociception2.56625321
5MP0004147_increased_porphyrin_level2.48491066
6MP0002653_abnormal_ependyma_morphology2.47397919
7MP0003011_delayed_dark_adaptation2.42466286
8MP0006072_abnormal_retinal_apoptosis2.41882776
9MP0002102_abnormal_ear_morphology2.37516324
10MP0008789_abnormal_olfactory_epithelium2.32824427
11MP0000049_abnormal_middle_ear2.23505188
12MP0005084_abnormal_gallbladder_morpholo2.13051028
13MP0005646_abnormal_pituitary_gland2.05256467
14MP0003880_abnormal_central_pattern2.02132832
15MP0006292_abnormal_olfactory_placode1.87509577
16MP0004133_heterotaxia1.86392957
17MP0005075_abnormal_melanosome_morpholog1.84387464
18MP0002234_abnormal_pharynx_morphology1.68407177
19MP0003136_yellow_coat_color1.67249569
20MP0001984_abnormal_olfaction1.64833884
21MP0005645_abnormal_hypothalamus_physiol1.61798286
22MP0002938_white_spotting1.57038768
23MP0005367_renal/urinary_system_phenotyp1.54852492
24MP0000516_abnormal_urinary_system1.54852492
25MP0008872_abnormal_physiological_respon1.50074786
26MP0002163_abnormal_gland_morphology1.48674824
27MP0008058_abnormal_DNA_repair1.47631027
28MP0009780_abnormal_chondrocyte_physiolo1.46114283
29MP0002272_abnormal_nervous_system1.44628538
30MP0000631_abnormal_neuroendocrine_gland1.43003475
31MP0005253_abnormal_eye_physiology1.42366470
32MP0004215_abnormal_myocardial_fiber1.41403277
33MP0005174_abnormal_tail_pigmentation1.39048001
34MP0001986_abnormal_taste_sensitivity1.38558420
35MP0003937_abnormal_limbs/digits/tail_de1.38512978
36MP0008877_abnormal_DNA_methylation1.36901300
37MP0006054_spinal_hemorrhage1.34945918
38MP0005551_abnormal_eye_electrophysiolog1.30618180
39MP0005394_taste/olfaction_phenotype1.30589461
40MP0005499_abnormal_olfactory_system1.30589461
41MP0002233_abnormal_nose_morphology1.29187641
42MP0003806_abnormal_nucleotide_metabolis1.26187737
43MP0008875_abnormal_xenobiotic_pharmacok1.25907096
44MP0002177_abnormal_outer_ear1.25771818
45MP0000372_irregular_coat_pigmentation1.22869533
46MP0001486_abnormal_startle_reflex1.20192294
47MP0004145_abnormal_muscle_electrophysio1.17296168
48MP0003186_abnormal_redox_activity1.15372849
49MP0008775_abnormal_heart_ventricle1.14403859
50MP0002733_abnormal_thermal_nociception1.14384846
51MP0004043_abnormal_pH_regulation1.13618380
52MP0009745_abnormal_behavioral_response1.12913223
53MP0002138_abnormal_hepatobiliary_system1.11967149
54MP0002095_abnormal_skin_pigmentation1.11214461
55MP0002127_abnormal_cardiovascular_syste1.11209095
56MP0000026_abnormal_inner_ear1.10510544
57MP0001346_abnormal_lacrimal_gland1.10204532
58MP0004885_abnormal_endolymph1.08658546
59MP0003693_abnormal_embryo_hatching1.07980886
60MP0003938_abnormal_ear_development1.06916108
61MP0005379_endocrine/exocrine_gland_phen1.06069352
62MP0005167_abnormal_blood-brain_barrier1.05685655
63MP0000566_synostosis1.05107734
64MP0001485_abnormal_pinna_reflex1.04472258
65MP0002876_abnormal_thyroid_physiology1.04436473
66MP0005195_abnormal_posterior_eye1.02672127
67MP0001501_abnormal_sleep_pattern1.01297008
68MP0001963_abnormal_hearing_physiology1.01232156
69MP0003111_abnormal_nucleus_morphology0.99826824
70MP0001970_abnormal_pain_threshold0.98291759
71MP0001764_abnormal_homeostasis0.97720126
72MP0004084_abnormal_cardiac_muscle0.97221404
73MP0010329_abnormal_lipoprotein_level0.96785467
74MP0003718_maternal_effect0.96597342
75MP0000613_abnormal_salivary_gland0.95694487
76MP0002277_abnormal_respiratory_mucosa0.94029809
77MP0005391_vision/eye_phenotype0.92733650
78MP0003786_premature_aging0.92235145
79MP0002752_abnormal_somatic_nervous0.89527042
80MP0002734_abnormal_mechanical_nocicepti0.88855251
81MP0002254_reproductive_system_inflammat0.88420994
82MP0001905_abnormal_dopamine_level0.82538685
83MP0010094_abnormal_chromosome_stability0.81814571
84MP0000015_abnormal_ear_pigmentation0.80449761
85MP0002735_abnormal_chemical_nociception0.80229820
86MP0003122_maternal_imprinting0.79169490
87MP0005671_abnormal_response_to0.77435660
88MP0008932_abnormal_embryonic_tissue0.76858699
89MP0003119_abnormal_digestive_system0.76721770
90MP0002184_abnormal_innervation0.76098955
91MP0002282_abnormal_trachea_morphology0.74927923
92MP0001666_abnormal_nutrient_absorption0.73404208
93MP0000749_muscle_degeneration0.72684062
94MP0002063_abnormal_learning/memory/cond0.72089240
95MP0002210_abnormal_sex_determination0.71514017
96MP0006035_abnormal_mitochondrial_morpho0.71190365
97MP0002067_abnormal_sensory_capabilities0.70979651
98MP0002572_abnormal_emotion/affect_behav0.70389633
99MP0002148_abnormal_hypersensitivity_rea0.69993095
100MP0003890_abnormal_embryonic-extraembry0.69568566

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pupillary function (HP:0007686)4.84865207
23-Methylglutaconic aciduria (HP:0003535)3.92882212
3Stenosis of the external auditory canal (HP:0000402)3.73555260
4Abnormal delayed hypersensitivity skin test (HP:0002963)3.47703639
5Panhypogammaglobulinemia (HP:0003139)3.27492089
6Rectal fistula (HP:0100590)3.09056149
7Rectovaginal fistula (HP:0000143)3.09056149
8Acute encephalopathy (HP:0006846)3.01733250
9Abolished electroretinogram (ERG) (HP:0000550)2.93652555
10Colon cancer (HP:0003003)2.90265399
11Molar tooth sign on MRI (HP:0002419)2.88006349
12Abnormality of midbrain morphology (HP:0002418)2.88006349
13IgG deficiency (HP:0004315)2.86781023
14Keratoconus (HP:0000563)2.86594293
15Increased corneal curvature (HP:0100692)2.86594293
16Nephronophthisis (HP:0000090)2.82248552
17Medial flaring of the eyebrow (HP:0010747)2.78488455
18Hypoplasia of the pons (HP:0012110)2.77960322
19Abnormality of alanine metabolism (HP:0010916)2.68422325
20Hyperalaninemia (HP:0003348)2.68422325
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68422325
22Spinal muscular atrophy (HP:0007269)2.68419489
23Chorioretinal atrophy (HP:0000533)2.66402855
24Pendular nystagmus (HP:0012043)2.64519269
25Acute necrotizing encephalopathy (HP:0006965)2.61848454
26Abnormality of the labia minora (HP:0012880)2.56876610
27Abnormality of the pons (HP:0007361)2.53094424
28Congenital primary aphakia (HP:0007707)2.53013368
29Short 1st metacarpal (HP:0010034)2.51348178
30Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.51348178
31Delayed CNS myelination (HP:0002188)2.50948772
32Gait imbalance (HP:0002141)2.50877608
33Nephrogenic diabetes insipidus (HP:0009806)2.48170689
34Short hallux (HP:0010109)2.45566714
35Aplasia/Hypoplasia of the hallux (HP:0008362)2.43212270
36Increased serum pyruvate (HP:0003542)2.40498843
37Pancreatic fibrosis (HP:0100732)2.40354402
38Abnormality of the anterior horn cell (HP:0006802)2.37301325
39Degeneration of anterior horn cells (HP:0002398)2.37301325
40Abnormality of the renal medulla (HP:0100957)2.33438533
41Maternal diabetes (HP:0009800)2.32101514
42Limb dystonia (HP:0002451)2.31734253
43Pancreatic cysts (HP:0001737)2.30858288
44Intestinal fistula (HP:0100819)2.29246070
45Hyperglycinemia (HP:0002154)2.29125981
46Abnormal mitochondria in muscle tissue (HP:0008316)2.27596512
47Recurrent cutaneous fungal infections (HP:0011370)2.26842945
48Chronic mucocutaneous candidiasis (HP:0002728)2.26842945
49Increased IgM level (HP:0003496)2.21857926
50Vaginal fistula (HP:0004320)2.20793765
51Abnormality of T cell physiology (HP:0011840)2.20340957
52Abnormality of the 1st metacarpal (HP:0010009)2.17906775
53Severe visual impairment (HP:0001141)2.13773397
54Abnormality of eosinophils (HP:0001879)2.08924565
55Abnormality of cells of the erythroid lineage (HP:0012130)2.08619566
56Hypoproteinemia (HP:0003075)2.05550191
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04749655
58Progressive macrocephaly (HP:0004481)2.03754552
59Hypoplasia of the ulna (HP:0003022)2.02817349
60Spontaneous abortion (HP:0005268)2.01937594
61Aplasia/hypoplasia of the uterus (HP:0008684)2.01069762
62Severe combined immunodeficiency (HP:0004430)2.00871239
63Aplasia/Hypoplasia of the ulna (HP:0006495)2.00505124
64Hyperglycinuria (HP:0003108)1.98101724
65Sensorimotor neuropathy (HP:0007141)1.97714006
66Thyroiditis (HP:0100646)1.97137999
67Partial agenesis of the corpus callosum (HP:0001338)1.96471677
68Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94435121
69Hypoplasia of the thymus (HP:0000778)1.94329228
70Oligodactyly (hands) (HP:0001180)1.92661723
71Abnormality of glycolysis (HP:0004366)1.92563208
72Poor coordination (HP:0002370)1.90863473
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88992880
74Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88992880
75Septate vagina (HP:0001153)1.87799193
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87311226
77Postaxial hand polydactyly (HP:0001162)1.86489427
78Cerebral edema (HP:0002181)1.85686454
79Conjunctival hamartoma (HP:0100780)1.85222486
80Genital tract atresia (HP:0001827)1.84347033
81Retinal dysplasia (HP:0007973)1.83662047
82Abnormality of serum amino acid levels (HP:0003112)1.83503535
83Vaginal atresia (HP:0000148)1.83174822
84True hermaphroditism (HP:0010459)1.82942850
85Inability to walk (HP:0002540)1.81986887
86Decreased central vision (HP:0007663)1.80642510
87Eosinophilia (HP:0001880)1.78487138
88Abnormality of T cell number (HP:0011839)1.78225298
89Abnormal number of incisors (HP:0011064)1.77654132
90Abnormality of the proximal phalanges of the hand (HP:0009834)1.77635730
91Short tibia (HP:0005736)1.77589514
92Abnormal number of erythroid precursors (HP:0012131)1.76687984
93Primary adrenal insufficiency (HP:0008207)1.75604145
94Large eyes (HP:0001090)1.75583283
95Aplasia/Hypoplasia of the spleen (HP:0010451)1.75433712
96Abnormality of small intestinal villus morphology (HP:0011472)1.74563989
97Villous atrophy (HP:0011473)1.74563989
98Sclerocornea (HP:0000647)1.74446682
99Attenuation of retinal blood vessels (HP:0007843)1.74166841
100Intestinal atresia (HP:0011100)1.71365259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.57076472
2BUB12.94212298
3ZAK2.92743824
4TXK2.86188363
5VRK22.86095973
6VRK12.85128995
7MAP4K22.77289459
8STK392.34880623
9TTK2.31891065
10PINK12.29034968
11NUAK12.23926642
12MAP3K122.16535214
13MST42.15683391
14EPHA42.15097554
15PNCK2.04647252
16CCNB11.96685338
17PBK1.88154473
18WNK41.82311164
19PLK31.71866453
20NEK91.64848145
21TAF11.59560915
22NEK11.53439442
23DYRK21.44227476
24TLK11.41516373
25WEE11.39573548
26ADRBK21.36975412
27OXSR11.34022459
28BCKDK1.32350597
29MAP3K41.30651354
30SRPK11.27382120
31BMPR1B1.26863762
32PRKD31.24887766
33SCYL21.23540773
34TNIK1.20818565
35EIF2AK31.18874684
36CDC71.16261538
37MYLK1.12893722
38CDK81.10073167
39NME11.07908961
40PIK3CA1.07739961
41GRK10.99685650
42GRK50.93901024
43TNK20.93618519
44CSNK1G10.91989643
45CSNK1G30.91662082
46PLK40.88446023
47TIE10.87001457
48CSNK1G20.86426182
49PLK20.83997058
50MAPK130.82437374
51CAMK10.81899465
52DAPK10.80025387
53BCR0.79201138
54EIF2AK20.75804266
55KDR0.75730686
56ATR0.75629241
57WNK30.73143721
58STK160.71391310
59CAMK1G0.65238523
60CSNK1A1L0.64206724
61DAPK20.59996267
62FLT30.59519964
63ALK0.59417596
64MKNK20.59254248
65CAMK40.57911689
66TRIM280.55987049
67PRKCE0.55347464
68PRKCG0.54739441
69ERBB40.53501691
70PRKCQ0.50644181
71AURKB0.50413105
72PLK10.50334456
73OBSCN0.48249879
74IGF1R0.47535492
75CASK0.46780898
76CAMK1D0.46643996
77TSSK60.46638629
78LIMK10.43409372
79BRSK20.43035134
80MELK0.40765631
81CSNK1A10.40628843
82KIT0.40350293
83GRK70.39502986
84STK38L0.38904090
85PKN10.38779531
86NME20.38211003
87DAPK30.38099477
88ACVR1B0.37725465
89JAK30.37352782
90SGK20.36459640
91SGK4940.35776404
92SGK2230.35776404
93EIF2AK10.35655194
94PTK2B0.35494361
95CAMKK20.33895517
96MET0.33614574
97PIK3CG0.33592786
98MKNK10.33006963
99ATM0.31413515
100ILK0.30821554

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.43747266
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.05235956
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.93180741
4Proteasome_Homo sapiens_hsa030502.92084949
5Propanoate metabolism_Homo sapiens_hsa006402.56550954
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56336847
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47881713
8Homologous recombination_Homo sapiens_hsa034402.34432849
9RNA polymerase_Homo sapiens_hsa030202.34247554
10Oxidative phosphorylation_Homo sapiens_hsa001902.28713210
11Primary immunodeficiency_Homo sapiens_hsa053402.24243033
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02365110
13Parkinsons disease_Homo sapiens_hsa050121.93470374
14Linoleic acid metabolism_Homo sapiens_hsa005911.93082100
15Fatty acid elongation_Homo sapiens_hsa000621.85968953
16Pyruvate metabolism_Homo sapiens_hsa006201.85932697
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69627872
18Non-homologous end-joining_Homo sapiens_hsa034501.68883617
19Phototransduction_Homo sapiens_hsa047441.68112808
20Nucleotide excision repair_Homo sapiens_hsa034201.62601015
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58702394
22RNA degradation_Homo sapiens_hsa030181.53159716
23Spliceosome_Homo sapiens_hsa030401.49540967
24Basal transcription factors_Homo sapiens_hsa030221.45339914
25Mismatch repair_Homo sapiens_hsa034301.34901914
26Alzheimers disease_Homo sapiens_hsa050101.31094540
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30270384
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.30015324
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29381362
30Huntingtons disease_Homo sapiens_hsa050161.29157743
31Selenocompound metabolism_Homo sapiens_hsa004501.27353840
32Collecting duct acid secretion_Homo sapiens_hsa049661.24754720
33Caffeine metabolism_Homo sapiens_hsa002321.21766013
34Butanoate metabolism_Homo sapiens_hsa006501.21275481
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20853204
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18830011
37DNA replication_Homo sapiens_hsa030301.13108035
38Peroxisome_Homo sapiens_hsa041461.11148891
39Sulfur metabolism_Homo sapiens_hsa009201.10862236
40Hedgehog signaling pathway_Homo sapiens_hsa043401.06195468
41Purine metabolism_Homo sapiens_hsa002300.99524442
42Nitrogen metabolism_Homo sapiens_hsa009100.99139625
43beta-Alanine metabolism_Homo sapiens_hsa004100.97848128
44Ether lipid metabolism_Homo sapiens_hsa005650.97256520
45Nicotine addiction_Homo sapiens_hsa050330.96202798
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95347074
47Base excision repair_Homo sapiens_hsa034100.94756325
48Pyrimidine metabolism_Homo sapiens_hsa002400.94243549
49RNA transport_Homo sapiens_hsa030130.93839193
50Arachidonic acid metabolism_Homo sapiens_hsa005900.92326532
51One carbon pool by folate_Homo sapiens_hsa006700.91729681
52Retinol metabolism_Homo sapiens_hsa008300.88810936
53p53 signaling pathway_Homo sapiens_hsa041150.86856528
54Fatty acid metabolism_Homo sapiens_hsa012120.83723605
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81429843
56Basal cell carcinoma_Homo sapiens_hsa052170.79826904
57Autoimmune thyroid disease_Homo sapiens_hsa053200.74964874
58Steroid biosynthesis_Homo sapiens_hsa001000.73784869
59Chemical carcinogenesis_Homo sapiens_hsa052040.73244571
60Cardiac muscle contraction_Homo sapiens_hsa042600.71661164
61Fat digestion and absorption_Homo sapiens_hsa049750.71154943
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71024021
63Ovarian steroidogenesis_Homo sapiens_hsa049130.70490399
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70445026
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69808443
66Morphine addiction_Homo sapiens_hsa050320.68588809
67Asthma_Homo sapiens_hsa053100.68419164
68Regulation of autophagy_Homo sapiens_hsa041400.65737028
69Tryptophan metabolism_Homo sapiens_hsa003800.64689957
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64133630
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64102474
72Wnt signaling pathway_Homo sapiens_hsa043100.62824656
73Oocyte meiosis_Homo sapiens_hsa041140.62619492
74Sulfur relay system_Homo sapiens_hsa041220.62597978
75Glutamatergic synapse_Homo sapiens_hsa047240.62465340
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62329958
77Fanconi anemia pathway_Homo sapiens_hsa034600.60610179
78Metabolic pathways_Homo sapiens_hsa011000.58325983
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56949808
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54049135
81GABAergic synapse_Homo sapiens_hsa047270.53711067
82Ribosome_Homo sapiens_hsa030100.53459759
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52549412
84Circadian entrainment_Homo sapiens_hsa047130.51702352
85Carbon metabolism_Homo sapiens_hsa012000.48764412
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.47785629
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44101494
88Antigen processing and presentation_Homo sapiens_hsa046120.43973173
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43683933
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.41865913
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39322036
92Long-term depression_Homo sapiens_hsa047300.37723529
93Rheumatoid arthritis_Homo sapiens_hsa053230.37300107
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.37252032
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36270593
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35320486
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.34242230
98Oxytocin signaling pathway_Homo sapiens_hsa049210.33786187
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33777711
100Biosynthesis of amino acids_Homo sapiens_hsa012300.32352851

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