ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.47510510
2	histone mRNA catabolic process (GO:0071044)	5.85546196
3	L-fucose catabolic process (GO:0042355)	5.76691501
4	fucose catabolic process (GO:0019317)	5.76691501
5	L-fucose metabolic process (GO:0042354)	5.76691501
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.74612794
7	ATP synthesis coupled proton transport (GO:0015986)	4.74612794
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.32123267
9	response to pheromone (GO:0019236)	4.23151801
10	retinal cone cell development (GO:0046549)	3.85568535
11	cellular ketone body metabolic process (GO:0046950)	3.82199086
12	fucosylation (GO:0036065)	3.76364240
13	snRNA processing (GO:0016180)	3.59558093
14	cornea development in camera-type eye (GO:0061303)	3.58554356
15	basic amino acid transport (GO:0015802)	3.58172591
16	negative regulation of telomere maintenance (GO:0032205)	3.55702126
17	kynurenine metabolic process (GO:0070189)	3.52931171
18	indolalkylamine metabolic process (GO:0006586)	3.52133102
19	negative regulation of mast cell activation (GO:0033004)	3.48408028
20	detection of light stimulus involved in sensory perception (GO:0050962)	3.46349372
21	detection of light stimulus involved in visual perception (GO:0050908)	3.46349372
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.45938425
23	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.38472242
24	indole-containing compound catabolic process (GO:0042436)	3.37825880
25	indolalkylamine catabolic process (GO:0046218)	3.37825880
26	tryptophan catabolic process (GO:0006569)	3.37825880
27	cellular response to ATP (GO:0071318)	3.35253503
28	ketone body metabolic process (GO:1902224)	3.35074776
29	exogenous drug catabolic process (GO:0042738)	3.34663388
30	synaptic transmission, cholinergic (GO:0007271)	3.34603805
31	DNA deamination (GO:0045006)	3.30002003
32	tryptophan metabolic process (GO:0006568)	3.25924011
33	mRNA cleavage (GO:0006379)	3.24018288
34	neural tube formation (GO:0001841)	3.22808621
35	regulation of hippo signaling (GO:0035330)	3.19570942
36	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.12314482
37	maturation of 5.8S rRNA (GO:0000460)	3.07819461
38	snRNA metabolic process (GO:0016073)	3.07729289
39	histone mRNA metabolic process (GO:0008334)	3.07387057
40	epithelial cilium movement (GO:0003351)	3.06777429
41	ATP biosynthetic process (GO:0006754)	3.04053811
42	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.03659191
43	drug catabolic process (GO:0042737)	3.02193263
44	piRNA metabolic process (GO:0034587)	2.96998279
45	coenzyme catabolic process (GO:0009109)	2.96233011
46	kidney morphogenesis (GO:0060993)	2.95515839
47	indole-containing compound metabolic process (GO:0042430)	2.90338154
48	pseudouridine synthesis (GO:0001522)	2.89888973
49	protein-cofactor linkage (GO:0018065)	2.89455139
50	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.89454277
51	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.89131905
52	sulfation (GO:0051923)	2.87496933
53	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.85197281
54	auditory receptor cell stereocilium organization (GO:0060088)	2.84979457
55	postsynaptic membrane organization (GO:0001941)	2.84662212
56	protein polyglutamylation (GO:0018095)	2.82156228
57	protein import into peroxisome matrix (GO:0016558)	2.80758868
58	multicellular organism reproduction (GO:0032504)	2.80081025
59	vitamin catabolic process (GO:0009111)	2.79972909
60	fat-soluble vitamin catabolic process (GO:0042363)	2.79972909
61	axoneme assembly (GO:0035082)	2.79772932
62	nonmotile primary cilium assembly (GO:0035058)	2.78465231
63	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.75741380
64	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.75741380
65	regulation of translation, ncRNA-mediated (GO:0045974)	2.75741380
66	lysine metabolic process (GO:0006553)	2.75382422
67	lysine catabolic process (GO:0006554)	2.75382422
68	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.74964139
69	protein localization to cilium (GO:0061512)	2.74171790
70	mRNA polyadenylation (GO:0006378)	2.70643108
71	regulation of neurotransmitter uptake (GO:0051580)	2.70168617
72	protein prenylation (GO:0018342)	2.69146193
73	prenylation (GO:0097354)	2.69146193
74	positive regulation of CREB transcription factor activity (GO:0032793)	2.68167918
75	photoreceptor cell development (GO:0042461)	2.67132609
76	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.66137069
77	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.65926450
78	rhodopsin mediated signaling pathway (GO:0016056)	2.65599280
79	endoderm formation (GO:0001706)	2.64482521
80	cilium movement (GO:0003341)	2.63090897
81	reflex (GO:0060004)	2.62935949
82	positive regulation of defense response to virus by host (GO:0002230)	2.62805760
83	nephron tubule morphogenesis (GO:0072078)	2.58377418
84	nephron epithelium morphogenesis (GO:0072088)	2.58377418
85	inner ear receptor stereocilium organization (GO:0060122)	2.58251361
86	regulation of mesoderm development (GO:2000380)	2.57162493
87	regulation of isotype switching to IgG isotypes (GO:0048302)	2.57089960
88	opioid receptor signaling pathway (GO:0038003)	2.56265234
89	gamma-aminobutyric acid transport (GO:0015812)	2.55805241
90	regulation of posttranscriptional gene silencing (GO:0060147)	2.54802674
91	regulation of gene silencing by miRNA (GO:0060964)	2.54802674
92	regulation of gene silencing by RNA (GO:0060966)	2.54802674
93	head development (GO:0060322)	2.54113666
94	behavioral response to ethanol (GO:0048149)	2.51579190
95	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.51397981
96	positive regulation of meiosis (GO:0045836)	2.51373825
97	adaptation of signaling pathway (GO:0023058)	2.50716566
98	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.50644619
99	rRNA catabolic process (GO:0016075)	2.50326294
100	eye photoreceptor cell development (GO:0042462)	2.50285978

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.62631304
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.32823168
3	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	3.08037303
4	VDR_22108803_ChIP-Seq_LS180_Human	2.98786293
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.82054600
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.46934913
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42032157
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.29978060
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.26328778
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.19111459
11	EWS_26573619_Chip-Seq_HEK293_Human	2.06698652
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.01912034
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.82188884
14	TP53_22573176_ChIP-Seq_HFKS_Human	1.81630014
15	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.74991973
16	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.73208951
17	P300_19829295_ChIP-Seq_ESCs_Human	1.70899876
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.70178819
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.65505555
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.64945055
21	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.59158199
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59158199
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.57721348
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.57506814
25	AR_21572438_ChIP-Seq_LNCaP_Human	1.53493942
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.51042225
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.49110137
28	STAT3_23295773_ChIP-Seq_U87_Human	1.48539255
29	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48202587
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.47575476
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47184406
32	TCF4_23295773_ChIP-Seq_U87_Human	1.45384161
33	FUS_26573619_Chip-Seq_HEK293_Human	1.44710409
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.42706471
35	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42027632
36	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42027632
37	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.41183647
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36392716
39	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.35470945
40	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.35205114
41	NCOR_22424771_ChIP-Seq_293T_Human	1.31571634
42	AR_25329375_ChIP-Seq_VCAP_Human	1.29253138
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27680208
44	AR_20517297_ChIP-Seq_VCAP_Human	1.27237244
45	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.27018643
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26892483
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26865233
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.26157433
49	ERA_21632823_ChIP-Seq_H3396_Human	1.25983260
50	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22421394
51	HOXB7_26014856_ChIP-Seq_BT474_Human	1.22400058
52	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.21764215
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.21498745
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21264598
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20607815
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.20607815
57	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20124321
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20087199
59	P53_21459846_ChIP-Seq_SAOS-2_Human	1.19534033
60	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.19203487
61	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.18725373
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18702835
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18702835
64	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.17720553
65	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.17100702
66	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16972484
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16910812
68	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16868424
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15309521
70	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.15194496
71	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.14190487
72	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12511651
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12157745
74	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.11348389
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10087946
76	SMAD4_21799915_ChIP-Seq_A2780_Human	1.09972703
77	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.09130408
78	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09089323
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09087984
80	MYC_19829295_ChIP-Seq_ESCs_Human	1.09048030
81	DROSHA_22980978_ChIP-Seq_HELA_Human	1.08055301
82	TP53_16413492_ChIP-PET_HCT116_Human	1.07944178
83	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.07130169
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.07121713
85	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06700587
86	TCF4_22108803_ChIP-Seq_LS180_Human	1.05613449
87	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05111691
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04565450
89	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04430868
90	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03981021
91	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.03879196
92	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.03575129
93	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.00870703
94	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00355016
95	GATA3_26560356_Chip-Seq_TH2_Human	0.99740141
96	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99702177
97	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99183204
98	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.99134958
99	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.98527759
100	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.98043320

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004043_abnormal_pH_regulation	3.12831504
2	MP0004147_increased_porphyrin_level	3.12403257
3	MP0003646_muscle_fatigue	2.89166299
4	MP0008875_abnormal_xenobiotic_pharmacok	2.77460675
5	MP0003195_calcinosis	2.71641122
6	MP0008872_abnormal_physiological_respon	2.52209224
7	MP0005551_abnormal_eye_electrophysiolog	2.38447838
8	MP0009745_abnormal_behavioral_response	2.28573657
9	MP0004742_abnormal_vestibular_system	2.13421975
10	MP0002653_abnormal_ependyma_morphology	2.13027086
11	MP0008877_abnormal_DNA_methylation	2.10307999
12	MP0002102_abnormal_ear_morphology	2.06561841
13	MP0004885_abnormal_endolymph	2.05522363
14	MP0000427_abnormal_hair_cycle	2.04606924
15	MP0001986_abnormal_taste_sensitivity	1.96796165
16	MP0001968_abnormal_touch/_nociception	1.91806119
17	MP0002876_abnormal_thyroid_physiology	1.84501114
18	MP0005645_abnormal_hypothalamus_physiol	1.82989769
19	MP0003136_yellow_coat_color	1.80647662
20	MP0006072_abnormal_retinal_apoptosis	1.77686210
21	MP0005084_abnormal_gallbladder_morpholo	1.74305944
22	MP0004142_abnormal_muscle_tone	1.71734829
23	MP0005167_abnormal_blood-brain_barrier	1.70191425
24	MP0002138_abnormal_hepatobiliary_system	1.69729779
25	MP0004133_heterotaxia	1.63639932
26	MP0001501_abnormal_sleep_pattern	1.60038784
27	MP0002735_abnormal_chemical_nociception	1.57513075
28	MP0002736_abnormal_nociception_after	1.55320154
29	MP0002272_abnormal_nervous_system	1.55050811
30	MP0005253_abnormal_eye_physiology	1.54477654
31	MP0001485_abnormal_pinna_reflex	1.52003339
32	MP0003787_abnormal_imprinting	1.50081683
33	MP0005646_abnormal_pituitary_gland	1.45426729
34	MP0002928_abnormal_bile_duct	1.45377111
35	MP0003718_maternal_effect	1.43374748
36	MP0002837_dystrophic_cardiac_calcinosis	1.42509310
37	MP0002938_white_spotting	1.41049015
38	MP0003880_abnormal_central_pattern	1.37398512
39	MP0000383_abnormal_hair_follicle	1.36941920
40	MP0009046_muscle_twitch	1.36370799
41	MP0002064_seizures	1.36263922
42	MP0002638_abnormal_pupillary_reflex	1.35915408
43	MP0000566_synostosis	1.35698461
44	MP0004145_abnormal_muscle_electrophysio	1.30054079
45	MP0006276_abnormal_autonomic_nervous	1.25758501
46	MP0003011_delayed_dark_adaptation	1.22969301
47	MP0003635_abnormal_synaptic_transmissio	1.22258261
48	MP0002557_abnormal_social/conspecific_i	1.21280318
49	MP0002572_abnormal_emotion/affect_behav	1.20878453
50	MP0002067_abnormal_sensory_capabilities	1.20357405
51	MP0002063_abnormal_learning/memory/cond	1.20248373
52	MP0001502_abnormal_circadian_rhythm	1.17071878
53	MP0003890_abnormal_embryonic-extraembry	1.16705187
54	MP0009780_abnormal_chondrocyte_physiolo	1.14373992
55	MP0005365_abnormal_bile_salt	1.12530682
56	MP0005195_abnormal_posterior_eye	1.11526746
57	MP0002733_abnormal_thermal_nociception	1.11499046
58	MP0001486_abnormal_startle_reflex	1.09110613
59	MP0000631_abnormal_neuroendocrine_gland	1.07706945
60	MP0001919_abnormal_reproductive_system	1.07567968
61	MP0005386_behavior/neurological_phenoty	1.07349880
62	MP0004924_abnormal_behavior	1.07349880
63	MP0001970_abnormal_pain_threshold	1.06307826
64	MP0002752_abnormal_somatic_nervous	1.06209557
65	MP0006292_abnormal_olfactory_placode	1.05901911
66	MP0000026_abnormal_inner_ear	1.05640249
67	MP0001529_abnormal_vocalization	1.03370907
68	MP0005377_hearing/vestibular/ear_phenot	1.03176045
69	MP0003878_abnormal_ear_physiology	1.03176045
70	MP0002822_catalepsy	1.01517703
71	MP0002234_abnormal_pharynx_morphology	1.00072970
72	MP0000778_abnormal_nervous_system	0.98667646
73	MP0002184_abnormal_innervation	0.97582013
74	MP0000685_abnormal_immune_system	0.95899125
75	MP0000569_abnormal_digit_pigmentation	0.94757825
76	MP0005085_abnormal_gallbladder_physiolo	0.94674434
77	MP0001963_abnormal_hearing_physiology	0.94528969
78	MP0003119_abnormal_digestive_system	0.94492730
79	MP0009764_decreased_sensitivity_to	0.93188082
80	MP0002229_neurodegeneration	0.93020048
81	MP0005410_abnormal_fertilization	0.90579189
82	MP0008775_abnormal_heart_ventricle	0.89018623
83	MP0003045_fibrosis	0.88928770
84	MP0001664_abnormal_digestion	0.88574511
85	MP0002751_abnormal_autonomic_nervous	0.87761519
86	MP0005389_reproductive_system_phenotype	0.87647706
87	MP0002277_abnormal_respiratory_mucosa	0.86765720
88	MP0000470_abnormal_stomach_morphology	0.84012702
89	MP0001835_abnormal_antigen_presentation	0.83770033
90	MP0005332_abnormal_amino_acid	0.81150223
91	MP0003879_abnormal_hair_cell	0.80405029
92	MP0001324_abnormal_eye_pigmentation	0.78002976
93	MP0005671_abnormal_response_to	0.76825877
94	MP0000955_abnormal_spinal_cord	0.76526792
95	MP0000230_abnormal_systemic_arterial	0.75902953
96	MP0001873_stomach_inflammation	0.75231229
97	MP0001663_abnormal_digestive_system	0.75190068
98	MP0004019_abnormal_vitamin_homeostasis	0.74410969
99	MP0002693_abnormal_pancreas_physiology	0.73724158
100	MP0010386_abnormal_urinary_bladder	0.71721001

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.96312998
2	Abnormality of alanine metabolism (HP:0010916)	4.93993054
3	Hyperalaninemia (HP:0003348)	4.93993054
4	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.93993054
5	Pancreatic cysts (HP:0001737)	3.89563576
6	Abnormality of midbrain morphology (HP:0002418)	3.80951239
7	Molar tooth sign on MRI (HP:0002419)	3.80951239
8	Decreased circulating renin level (HP:0003351)	3.71334023
9	Attenuation of retinal blood vessels (HP:0007843)	3.61309653
10	Pancreatic fibrosis (HP:0100732)	3.33975608
11	Abnormality of the renal cortex (HP:0011035)	3.33305266
12	Nephronophthisis (HP:0000090)	3.32692890
13	Progressive inability to walk (HP:0002505)	3.26828144
14	Inability to walk (HP:0002540)	3.19102099
15	Abnormal drinking behavior (HP:0030082)	3.14441125
16	Polydipsia (HP:0001959)	3.14441125
17	Pendular nystagmus (HP:0012043)	3.13231251
18	True hermaphroditism (HP:0010459)	3.13194483
19	Type II lissencephaly (HP:0007260)	3.07979557
20	Abnormality of the renal medulla (HP:0100957)	3.05655148
21	Stomatitis (HP:0010280)	2.98601208
22	Absent/shortened dynein arms (HP:0200106)	2.79668459
23	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.79668459
24	Congenital, generalized hypertrichosis (HP:0004540)	2.73293382
25	Abolished electroretinogram (ERG) (HP:0000550)	2.66937819
26	Tubular atrophy (HP:0000092)	2.65749577
27	Hyperventilation (HP:0002883)	2.57739718
28	Chorioretinal atrophy (HP:0000533)	2.56117399
29	Concave nail (HP:0001598)	2.53018431
30	Lissencephaly (HP:0001339)	2.51716798
31	Polyuria (HP:0000103)	2.51687261
32	Increased corneal curvature (HP:0100692)	2.49963327
33	Keratoconus (HP:0000563)	2.49963327
34	Progressive cerebellar ataxia (HP:0002073)	2.43289558
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.34690440
36	Cystic liver disease (HP:0006706)	2.32498691
37	Chronic hepatic failure (HP:0100626)	2.31169577
38	Tachypnea (HP:0002789)	2.30757956
39	Febrile seizures (HP:0002373)	2.30075642
40	Oral leukoplakia (HP:0002745)	2.29747227
41	Abnormal respiratory motile cilium morphology (HP:0005938)	2.29128836
42	Abnormal respiratory epithelium morphology (HP:0012253)	2.29128836
43	Partial agenesis of the corpus callosum (HP:0001338)	2.28549411
44	Alkalosis (HP:0001948)	2.28310195
45	Pachygyria (HP:0001302)	2.27714838
46	Abnormality of the pons (HP:0007361)	2.27528675
47	Hypoplasia of the pons (HP:0012110)	2.27255025
48	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.26728460
49	Sclerocornea (HP:0000647)	2.22562112
50	Broad-based gait (HP:0002136)	2.22086030
51	Decreased central vision (HP:0007663)	2.21107775
52	Large for gestational age (HP:0001520)	2.21076106
53	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.19039420
54	Ketosis (HP:0001946)	2.17116156
55	Abnormality of macular pigmentation (HP:0008002)	2.16811819
56	Abnormality of renin-angiotensin system (HP:0000847)	2.13454554
57	Genetic anticipation (HP:0003743)	2.10987396
58	Ketoacidosis (HP:0001993)	2.10560976
59	Abnormal ciliary motility (HP:0012262)	2.06846950
60	Hypoplasia of the uterus (HP:0000013)	2.05293290
61	Severe muscular hypotonia (HP:0006829)	2.03351294
62	Abnormal urine output (HP:0012590)	2.03278995
63	Metabolic alkalosis (HP:0200114)	2.03185152
64	Tongue fasciculations (HP:0001308)	2.02790044
65	Duplicated collecting system (HP:0000081)	2.02346925
66	Bilateral microphthalmos (HP:0007633)	2.02189763
67	Optic nerve hypoplasia (HP:0000609)	1.99951987
68	Optic disc pallor (HP:0000543)	1.98761651
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.98746046
70	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.98082748
71	Widely spaced teeth (HP:0000687)	1.97185404
72	Hypoplastic nipples (HP:0002557)	1.96921247
73	Cerebellar dysplasia (HP:0007033)	1.96754264
74	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.95356633
75	Bile duct proliferation (HP:0001408)	1.95280906
76	Abnormal biliary tract physiology (HP:0012439)	1.95280906
77	Gaze-evoked nystagmus (HP:0000640)	1.93890540
78	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.93091009
79	Protruding tongue (HP:0010808)	1.92178076
80	Renal cortical cysts (HP:0000803)	1.91606447
81	Ectopic kidney (HP:0000086)	1.91490977
82	Clumsiness (HP:0002312)	1.89067051
83	Medial flaring of the eyebrow (HP:0010747)	1.88104765
84	Abnormality of the renal collecting system (HP:0004742)	1.87606784
85	Bulbous nose (HP:0000414)	1.86842049
86	Congenital hepatic fibrosis (HP:0002612)	1.86815351
87	Type 2 muscle fiber atrophy (HP:0003554)	1.86548229
88	Hypoplasia of the fovea (HP:0007750)	1.86536376
89	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.86536376
90	Oligodactyly (hands) (HP:0001180)	1.86124212
91	Rib fusion (HP:0000902)	1.85574330
92	Bony spicule pigmentary retinopathy (HP:0007737)	1.85247353
93	Anencephaly (HP:0002323)	1.82479740
94	Tubulointerstitial fibrosis (HP:0005576)	1.82060442
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.81434896
96	Conical tooth (HP:0000698)	1.80403708
97	Abnormal number of erythroid precursors (HP:0012131)	1.77467420
98	Abnormality of transition element cation homeostasis (HP:0011030)	1.74099055
99	Polyphagia (HP:0002591)	1.72975828
100	Abnormality of the fovea (HP:0000493)	1.71159462

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	5.27799352
2	DAPK2	4.13564663
3	BMPR1B	4.10275455
4	TLK1	4.04655196
5	WNK4	3.12547202
6	GRK1	2.99205277
7	MAP4K2	2.78210691
8	TNIK	2.57181321
9	ACVR1B	2.54086979
10	FRK	2.53740002
11	PINK1	2.45404981
12	TGFBR1	2.42846037
13	MARK1	2.37599477
14	TSSK6	2.08898448
15	ZAK	2.06468103
16	TXK	1.91550314
17	ADRBK1	1.68109953
18	WNK3	1.59839791
19	TAOK3	1.59052130
20	MAPK13	1.58154236
21	NUAK1	1.35883150
22	NEK9	1.29326208
23	SIK2	1.25807384
24	NME1	1.22681244
25	BCKDK	1.22415268
26	STK38L	1.22047121
27	MAP2K7	1.18236959
28	OXSR1	1.16650832
29	DYRK2	1.10468322
30	STK39	1.08263525
31	CAMKK2	1.05408862
32	WNK1	0.98576328
33	MAP3K4	0.96397022
34	CDK8	0.88334948
35	CASK	0.88126034
36	INSRR	0.87662254
37	PAK3	0.86558729
38	KIT	0.86360067
39	NTRK2	0.85732751
40	NLK	0.85532454
41	IRAK1	0.85423137
42	TIE1	0.83676220
43	PRKCE	0.79357226
44	MAP4K1	0.79227962
45	RPS6KA5	0.78329986
46	PRKCI	0.73960786
47	PTK2B	0.71013470
48	PRKCG	0.70768574
49	CAMK1	0.70445680
50	PHKG2	0.70024288
51	PHKG1	0.70024288
52	IKBKB	0.68231969
53	MAPKAPK3	0.67795167
54	PNCK	0.63049082
55	MKNK2	0.59423311
56	TEC	0.58335346
57	SYK	0.58026253
58	EPHB2	0.57631049
59	RPS6KA6	0.57387254
60	PKN1	0.55778948
61	ITK	0.55016090
62	MAPK15	0.54739824
63	ATR	0.53054637
64	PRKCQ	0.52058339
65	NEK2	0.49678646
66	CAMK2A	0.48842785
67	CAMK1D	0.47167215
68	FLT3	0.46007393
69	CAMK4	0.44960273
70	NTRK3	0.44712331
71	MAPKAPK5	0.44464506
72	STK3	0.44387137
73	PRKG1	0.41616774
74	MET	0.40541648
75	GRK7	0.39960997
76	CAMK1G	0.39126637
77	PIK3CA	0.38699253
78	PRKACA	0.37932109
79	PRKAA2	0.37873636
80	PRKCZ	0.37778300
81	CSNK1G2	0.35983176
82	IKBKE	0.35944123
83	MAP2K2	0.35648406
84	CHUK	0.35176086
85	CSNK1A1	0.34784250
86	MAP2K6	0.34546319
87	CDK3	0.33240858
88	CAMKK1	0.32505439
89	CHEK2	0.32193876
90	PASK	0.31774217
91	STK11	0.31377077
92	BCR	0.31354050
93	PRKCH	0.29636742
94	MKNK1	0.29352503
95	MAP2K1	0.28600594
96	PRKCA	0.28549991
97	CSNK1D	0.25633329
98	PLK2	0.24079726
99	PLK1	0.23073171
100	TRIM28	0.22862677

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.66434578
2	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.84985260
3	Phototransduction_Homo sapiens_hsa04744	2.65944905
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.58655226
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.47635254
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.45852317
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.40101878
8	Nicotine addiction_Homo sapiens_hsa05033	2.35127032
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.29336126
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.25877265
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.12758822
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.11576803
13	Asthma_Homo sapiens_hsa05310	2.07149660
14	Butanoate metabolism_Homo sapiens_hsa00650	1.94714814
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.94412211
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.94010540
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.91847896
18	Basal transcription factors_Homo sapiens_hsa03022	1.75902768
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.67450843
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.64142830
21	Allograft rejection_Homo sapiens_hsa05330	1.63451600
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.61097290
23	Caffeine metabolism_Homo sapiens_hsa00232	1.54741648
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.53542668
25	Oxidative phosphorylation_Homo sapiens_hsa00190	1.48870855
26	Morphine addiction_Homo sapiens_hsa05032	1.48350439
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.46781159
28	Olfactory transduction_Homo sapiens_hsa04740	1.45392802
29	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.42284923
30	RNA polymerase_Homo sapiens_hsa03020	1.34074938
31	Histidine metabolism_Homo sapiens_hsa00340	1.30404916
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.24259674
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.22161449
34	Taste transduction_Homo sapiens_hsa04742	1.22153813
35	Circadian entrainment_Homo sapiens_hsa04713	1.21850234
36	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.13230376
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.10579364
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.09277250
39	ABC transporters_Homo sapiens_hsa02010	1.06244975
40	Parkinsons disease_Homo sapiens_hsa05012	1.04677162
41	Serotonergic synapse_Homo sapiens_hsa04726	1.03960489
42	GABAergic synapse_Homo sapiens_hsa04727	1.03696817
43	Glutamatergic synapse_Homo sapiens_hsa04724	1.02683445
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01876223
45	Homologous recombination_Homo sapiens_hsa03440	1.01452386
46	One carbon pool by folate_Homo sapiens_hsa00670	0.99899648
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.98501074
48	Insulin secretion_Homo sapiens_hsa04911	0.98400367
49	Protein export_Homo sapiens_hsa03060	0.97594761
50	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.97027222
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95203190
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.90847679
53	Ribosome_Homo sapiens_hsa03010	0.90276715
54	Calcium signaling pathway_Homo sapiens_hsa04020	0.84319675
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.83686690
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.83292737
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.82109640
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81625084
59	Graft-versus-host disease_Homo sapiens_hsa05332	0.81370269
60	Primary immunodeficiency_Homo sapiens_hsa05340	0.78733612
61	Peroxisome_Homo sapiens_hsa04146	0.76461479
62	Alzheimers disease_Homo sapiens_hsa05010	0.76451621
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.76447019
64	RNA degradation_Homo sapiens_hsa03018	0.75275321
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70279339
66	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.70174500
67	Salivary secretion_Homo sapiens_hsa04970	0.68241903
68	Huntingtons disease_Homo sapiens_hsa05016	0.68203548
69	Mineral absorption_Homo sapiens_hsa04978	0.68133115
70	Lysine degradation_Homo sapiens_hsa00310	0.66040307
71	Retinol metabolism_Homo sapiens_hsa00830	0.64929327
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62643102
73	Propanoate metabolism_Homo sapiens_hsa00640	0.62178210
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.61103793
75	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56378690
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.55144953
77	Sulfur metabolism_Homo sapiens_hsa00920	0.53733358
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51556784
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51286168
80	Cocaine addiction_Homo sapiens_hsa05030	0.49829302
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47564425
82	Long-term depression_Homo sapiens_hsa04730	0.46883663
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.46768093
84	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.44832806
85	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.44715413
86	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.42692158
87	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.39633039
88	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.38422576
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.37454917
90	Metabolic pathways_Homo sapiens_hsa01100	0.36697599
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.35516511
92	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.35231132
93	Cholinergic synapse_Homo sapiens_hsa04725	0.33502041
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.32666248
95	Sulfur relay system_Homo sapiens_hsa04122	0.32498963
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32411860
97	Amphetamine addiction_Homo sapiens_hsa05031	0.31132132
98	Regulation of autophagy_Homo sapiens_hsa04140	0.30110927
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.28663992
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.25695812

RBMY2FP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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