RBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.20213945
2regulation of guanylate cyclase activity (GO:0031282)7.55834475
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)7.53138025
4virion attachment to host cell (GO:0019062)7.31509763
5adhesion of symbiont to host cell (GO:0044650)7.31509763
6phospholipid efflux (GO:0033700)7.03714829
7regulation of cholesterol esterification (GO:0010872)6.96385821
8positive regulation of triglyceride lipase activity (GO:0061365)6.84703581
9positive regulation of lipoprotein lipase activity (GO:0051006)6.84703581
10regulation of triglyceride catabolic process (GO:0010896)6.58984046
11fat-soluble vitamin biosynthetic process (GO:0042362)6.37355564
12plasma lipoprotein particle assembly (GO:0034377)6.21354842
13flavonoid metabolic process (GO:0009812)6.14007683
14positive regulation of guanylate cyclase activity (GO:0031284)6.04986460
15adhesion of symbiont to host (GO:0044406)6.04852253
16protein-lipid complex assembly (GO:0065005)5.89773665
17fructose metabolic process (GO:0006000)5.67941575
18actin filament depolymerization (GO:0030042)5.58756724
19digestive system process (GO:0022600)5.49905787
20cholesterol efflux (GO:0033344)5.49024347
21drug catabolic process (GO:0042737)5.46982767
22hormone catabolic process (GO:0042447)5.45381696
23lipoprotein metabolic process (GO:0042157)5.21919504
24regulation of cellular extravasation (GO:0002691)5.14991665
25modified amino acid transport (GO:0072337)5.06091994
26reverse cholesterol transport (GO:0043691)5.03173373
27positive regulation of fatty acid biosynthetic process (GO:0045723)4.94222594
28drug metabolic process (GO:0017144)4.93095179
29very-low-density lipoprotein particle assembly (GO:0034379)4.90942651
30drinking behavior (GO:0042756)4.89840929
313-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.77746606
32purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.77746606
33peptide catabolic process (GO:0043171)4.75347554
34peptide hormone processing (GO:0016486)4.74653693
35diacylglycerol metabolic process (GO:0046339)4.65497511
36urea cycle (GO:0000050)4.64583632
37bile acid and bile salt transport (GO:0015721)4.60732705
38regulation of cGMP biosynthetic process (GO:0030826)4.58039062
39digestion (GO:0007586)4.55858717
40glucose 6-phosphate metabolic process (GO:0051156)4.55066689
41cellular glucuronidation (GO:0052695)4.51382810
42high-density lipoprotein particle remodeling (GO:0034375)4.47915861
43glucuronate metabolic process (GO:0019585)4.47848798
44uronic acid metabolic process (GO:0006063)4.47848798
45urea metabolic process (GO:0019627)4.44795893
46purine nucleotide salvage (GO:0032261)4.43845904
47cholesterol transport (GO:0030301)4.41259990
48sterol transport (GO:0015918)4.41259990
49glycolipid catabolic process (GO:0019377)4.32064954
50antibacterial humoral response (GO:0019731)4.32064774
51cholesterol homeostasis (GO:0042632)4.30919404
52glycosphingolipid catabolic process (GO:0046479)4.26622967
53sterol homeostasis (GO:0055092)4.26247095
54receptor guanylyl cyclase signaling pathway (GO:0007168)4.25249889
55lipoprotein transport (GO:0042953)4.22972303
56negative regulation of sterol transport (GO:0032372)4.18742101
57negative regulation of cholesterol transport (GO:0032375)4.18742101
58regulation of lipoprotein metabolic process (GO:0050746)4.18477124
59response to hepatocyte growth factor (GO:0035728)4.17508670
60cellular response to hepatocyte growth factor stimulus (GO:0035729)4.17508670
61antimicrobial humoral response (GO:0019730)4.16716901
62protein-lipid complex remodeling (GO:0034368)4.15987064
63macromolecular complex remodeling (GO:0034367)4.15987064
64plasma lipoprotein particle remodeling (GO:0034369)4.15987064
65positive regulation of triglyceride metabolic process (GO:0090208)4.12295418
66nitrogen cycle metabolic process (GO:0071941)4.10568632
67response to hydroperoxide (GO:0033194)4.02288813
68plasma lipoprotein particle organization (GO:0071827)3.97205949
69protein-lipid complex subunit organization (GO:0071825)3.93329710
70bundle of His cell to Purkinje myocyte communication (GO:0086069)3.91104746
71regulation of vitamin metabolic process (GO:0030656)3.86809317
72cellular response to nitric oxide (GO:0071732)3.85274930
73glutamine family amino acid biosynthetic process (GO:0009084)3.84520775
74renal system process involved in regulation of blood volume (GO:0001977)3.83644649
75regulation of cGMP metabolic process (GO:0030823)3.81192292
76NADH metabolic process (GO:0006734)3.78485976
77alkaloid metabolic process (GO:0009820)3.78030679
78oligosaccharide catabolic process (GO:0009313)3.77992622
79positive regulation of glycoprotein biosynthetic process (GO:0010560)3.77213146
80homocysteine metabolic process (GO:0050667)3.74471429
81positive regulation of lipid catabolic process (GO:0050996)3.74021044
82positive regulation of pseudopodium assembly (GO:0031274)3.68689393
83regulation of bile acid biosynthetic process (GO:0070857)3.68310505
84mRNA modification (GO:0016556)3.68019248
85regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.65196873
86vitamin transmembrane transport (GO:0035461)3.64638195
87response to phenylpropanoid (GO:0080184)3.64257677
88regulation of systemic arterial blood pressure by hormone (GO:0001990)3.63413296
89regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.63413296
90endocrine process (GO:0050886)3.63413296
91vitamin transport (GO:0051180)3.62436998
92sulfation (GO:0051923)3.58683808
93sphingomyelin metabolic process (GO:0006684)3.58189142
94arginine metabolic process (GO:0006525)3.53687718
95phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.52342927
96regulation of digestive system process (GO:0044058)3.49848215
97positive regulation of cGMP biosynthetic process (GO:0030828)3.49309975
98midgut development (GO:0007494)3.46990710
99thyroid hormone metabolic process (GO:0042403)3.44910725
100ceramide catabolic process (GO:0046514)3.44466038
101epoxygenase P450 pathway (GO:0019373)3.43055023
102fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.41340207
103exogenous drug catabolic process (GO:0042738)3.40497204
104glycosylceramide metabolic process (GO:0006677)3.39992400
105positive regulation of glycoprotein metabolic process (GO:1903020)3.38666263
106bile acid metabolic process (GO:0008206)3.38211243
107positive regulation of T cell differentiation in thymus (GO:0033089)3.37448238
108nucleoside diphosphate biosynthetic process (GO:0009133)3.37363061
109sulfate transmembrane transport (GO:1902358)3.35965885
110response to nitric oxide (GO:0071731)3.35872798
111innate immune response in mucosa (GO:0002227)3.34379725
112vitamin biosynthetic process (GO:0009110)3.34336493
113cytidine deamination (GO:0009972)3.33369212
114cytidine metabolic process (GO:0046087)3.33369212
115cytidine catabolic process (GO:0006216)3.33369212
116nucleobase catabolic process (GO:0046113)3.31783980
117regulation of pseudopodium assembly (GO:0031272)3.29797188
118regulation of cholesterol transport (GO:0032374)3.29161768
119regulation of sterol transport (GO:0032371)3.29161768
120cellular response to reactive nitrogen species (GO:1902170)3.26667765
121regulation of Golgi to plasma membrane protein transport (GO:0042996)3.25487118
122UDP-N-acetylglucosamine metabolic process (GO:0006047)3.23353790
123sulfur compound transport (GO:0072348)3.22607837
124hydrogen peroxide catabolic process (GO:0042744)3.22466036
125cellular response to oxygen radical (GO:0071450)3.22408494
126removal of superoxide radicals (GO:0019430)3.22408494
127cellular response to superoxide (GO:0071451)3.22408494
128regulation of cholesterol homeostasis (GO:2000188)3.21999264
129transepithelial transport (GO:0070633)3.19850076
130regulation of systemic arterial blood pressure (GO:0003073)3.19531399
131antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.17448055
132vitamin D metabolic process (GO:0042359)3.16565717
133cGMP biosynthetic process (GO:0006182)3.15814172
134L-ascorbic acid metabolic process (GO:0019852)3.14283715
135negative regulation of digestive system process (GO:0060457)3.12062571
136negative regulation of thymocyte apoptotic process (GO:0070244)3.11399844
137regulation of penile erection (GO:0060405)3.08517341
138phenylpropanoid metabolic process (GO:0009698)3.08133609
139cellular carbohydrate catabolic process (GO:0044275)3.07678421
140maintenance of gastrointestinal epithelium (GO:0030277)3.05723831
141polyol transport (GO:0015791)3.05681293
142transcytosis (GO:0045056)3.02736034
143bicarbonate transport (GO:0015701)3.01908894
144mature B cell differentiation involved in immune response (GO:0002313)2.99812591
145glycerol metabolic process (GO:0006071)2.99776825
146sperm capacitation (GO:0048240)2.96469222
147lipid homeostasis (GO:0055088)2.93597618
148L-alpha-amino acid transmembrane transport (GO:1902475)2.91689432
149histamine secretion (GO:0001821)2.91111058
150intestinal absorption (GO:0050892)13.0285239
151angiotensin maturation (GO:0002003)12.2390393
152intestinal cholesterol absorption (GO:0030299)12.0196978

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.08732342
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.21845315
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.48076395
4* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.39103099
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.23604908
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.10474418
7GATA4_25053715_ChIP-Seq_YYC3_Human2.97969664
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.92396420
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.76722007
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.68548777
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.65041903
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.52551971
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.51002154
14GATA6_25053715_ChIP-Seq_YYC3_Human2.49913709
15SOX2_20726797_ChIP-Seq_SW620_Human2.45569004
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.26134813
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99849882
18SRY_22984422_ChIP-ChIP_TESTIS_Rat1.90909368
19* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.90360377
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.87672458
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.75223153
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74290160
23NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.69942672
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69346999
25KLF5_25053715_ChIP-Seq_YYC3_Human1.66861974
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.58354805
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56295205
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52454676
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50415850
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.49735803
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49259099
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48408072
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47426497
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.46622940
35GATA1_22025678_ChIP-Seq_K562_Human1.45667000
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.45264346
37RUNX1_27514584_Chip-Seq_MCF-7_Human1.44539481
38GATA2_19941826_ChIP-Seq_K562_Human1.43764788
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43210581
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41526236
41CLOCK_20551151_ChIP-Seq_293T_Human1.41466537
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39193998
43HNF4A_19822575_ChIP-Seq_HepG2_Human1.39042910
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.36655944
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34365549
46RACK7_27058665_Chip-Seq_MCF-7_Human1.32470528
47CDX2_22108803_ChIP-Seq_LS180_Human1.31690663
48BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.31557761
49ATF3_27146783_Chip-Seq_COLON_Human1.30299442
50FOXA1_25552417_ChIP-Seq_VCAP_Human1.28907466
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20977837
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19967045
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.19252218
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18875229
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15997704
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14073443
57SA1_27219007_Chip-Seq_Bcells_Human1.13255918
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.13015824
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12344228
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12153703
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10874282
62RXR_22108803_ChIP-Seq_LS180_Human1.10263873
63CREB1_26743006_Chip-Seq_LNCaP_Human1.08026042
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07391287
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07325381
66JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04930474
67JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.04425691
68LXR_22292898_ChIP-Seq_THP-1_Human1.03980176
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03381576
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03056535
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02838414
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02515139
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02039206
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01730948
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01256039
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.01089283
77EGR1_19032775_ChIP-ChIP_M12_Human1.00861139
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98032348
79TET1_21451524_ChIP-Seq_MESCs_Mouse0.97415709
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96858602
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96128889
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95898235
83ESR1_21235772_ChIP-Seq_MCF-7_Human0.95525907
84CTCF_27219007_Chip-Seq_Bcells_Human0.94491711
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94231416
86CEBPB_22108803_ChIP-Seq_LS180_Human0.94230016
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94021656
88IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93443733
89AR_21909140_ChIP-Seq_LNCAP_Human0.92853891
90GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92733123
91P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91184530
92CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91160936
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90098576
94SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88926842
95BCOR_27268052_Chip-Seq_Bcells_Human0.88454695
96GATA1_19941826_ChIP-Seq_K562_Human0.88425581
97* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88269049
98BCL6_27268052_Chip-Seq_Bcells_Human0.88168451
99VDR_24787735_ChIP-Seq_THP-1_Human0.87965868
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86493728
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85669692
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84386724
103TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.84225113
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.84176990
105SOX2_22085726_ChIP-Seq_NPCs_Mouse0.83332447
106P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83249051
107FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82179068
108SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81812484
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81694449
110RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81217600
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81092564
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80524828
113* TP63_23658742_ChIP-Seq_EP156T_Human0.79343638
114VDR_22108803_ChIP-Seq_LS180_Human0.78917381
115NANOG_20526341_ChIP-Seq_ESCs_Human0.78608570
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78269677
117EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77803615
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77691326
119ZNF263_19887448_ChIP-Seq_K562_Human0.77077181
120STAT1_20625510_ChIP-Seq_HELA_Human0.77035614
121STAT6_21828071_ChIP-Seq_BEAS2B_Human0.76999648
122GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.76281185
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76178210
124SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76076773
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75564831
126KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75520761
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75218064
128TCF3_18692474_ChIP-Seq_MESCs_Mouse0.75165230
129SOX9_24532713_ChIP-Seq_HFSC_Mouse0.74719166
130DROSHA_22980978_ChIP-Seq_HELA_Human0.73796972
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.72638044
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.72638044
133GATA3_24758297_ChIP-Seq_MCF-7_Human0.71006286
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.70373765
135* TP63_22573176_ChIP-Seq_HFKS_Human0.68995292
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.68942403
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.67889147
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.67533397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell5.66094535
2* MP0001666_abnormal_nutrient_absorption5.26600580
3MP0003183_abnormal_peptide_metabolism4.66346315
4MP0002139_abnormal_hepatobiliary_system3.99415050
5MP0010234_abnormal_vibrissa_follicle3.75725007
6MP0003252_abnormal_bile_duct3.34372681
7MP0008875_abnormal_xenobiotic_pharmacok3.22876739
8MP0010329_abnormal_lipoprotein_level3.12399468
9MP0004264_abnormal_extraembryonic_tissu3.03661617
10MP0000462_abnormal_digestive_system3.03291061
11MP0005085_abnormal_gallbladder_physiolo2.85081109
12MP0003866_abnormal_defecation2.50638323
13MP0004147_increased_porphyrin_level2.26645474
14MP0002822_catalepsy2.13165188
15MP0005409_darkened_coat_color2.09525708
16MP0005360_urolithiasis10.2517054
17MP0005084_abnormal_gallbladder_morpholo1.99081015
18MP0009697_abnormal_copulation1.91810443
19MP0000537_abnormal_urethra_morphology1.85867879
20MP0004043_abnormal_pH_regulation1.74801604
21MP0003878_abnormal_ear_physiology1.71296106
22MP0005377_hearing/vestibular/ear_phenot1.71296106
23MP0003868_abnormal_feces_composition1.67661639
24MP0001664_abnormal_digestion1.66785185
25MP0002254_reproductive_system_inflammat1.61670134
26MP0005381_digestive/alimentary_phenotyp1.61636156
27MP0005448_abnormal_energy_balance1.60146250
28MP0003705_abnormal_hypodermis_morpholog1.57584325
29MP0001663_abnormal_digestive_system1.57542489
30MP0005670_abnormal_white_adipose1.57373682
31MP0003191_abnormal_cellular_cholesterol1.54533948
32MP0000538_abnormal_urinary_bladder1.53221664
33MP0005365_abnormal_bile_salt1.50637681
34MP0002089_abnormal_postnatal_growth/wei1.47447094
35MP0010352_gastrointestinal_tract_polyps1.46861700
36MP0010155_abnormal_intestine_physiology1.43627775
37MP0002796_impaired_skin_barrier1.43339858
38MP0003300_gastrointestinal_ulcer1.41585619
39MP0004858_abnormal_nervous_system1.37964170
40MP0006054_spinal_hemorrhage1.35335571
41MP0000477_abnormal_intestine_morphology1.33593527
42MP0001188_hyperpigmentation1.32381912
43MP0001873_stomach_inflammation1.32319460
44MP0009379_abnormal_foot_pigmentation1.30404190
45MP0005332_abnormal_amino_acid1.19293626
46MP0002118_abnormal_lipid_homeostasis1.14959756
47MP0001501_abnormal_sleep_pattern1.14487691
48MP0000490_abnormal_crypts_of1.12364627
49MP0004270_analgesia1.09661327
50MP0004782_abnormal_surfactant_physiolog1.07751722
51MP0000609_abnormal_liver_physiology1.04055214
52MP0005535_abnormal_body_temperature1.02150786
53MP0003806_abnormal_nucleotide_metabolis1.01059269
54MP0009643_abnormal_urine_homeostasis0.98713367
55MP0000467_abnormal_esophagus_morphology0.94776883
56MP0001849_ear_inflammation0.93446319
57* MP0004019_abnormal_vitamin_homeostasis0.93412555
58MP0009780_abnormal_chondrocyte_physiolo0.93046095
59MP0004947_skin_inflammation0.89569060
60MP0001845_abnormal_inflammatory_respons0.86816879
61MP0001756_abnormal_urination0.86437239
62MP0005501_abnormal_skin_physiology0.85358287
63MP0005167_abnormal_blood-brain_barrier0.83538361
64MP0008872_abnormal_physiological_respon0.82666480
65MP0003283_abnormal_digestive_organ0.78672728
66MP0005266_abnormal_metabolism0.78446444
67MP0010678_abnormal_skin_adnexa0.78412833
68MP0009053_abnormal_anal_canal0.76764213
69MP0002396_abnormal_hematopoietic_system0.76437790
70MP0005451_abnormal_body_composition0.76235085
71MP0002876_abnormal_thyroid_physiology0.75140730
72MP0002098_abnormal_vibrissa_morphology0.74088772
73MP0000516_abnormal_urinary_system0.73641013
74MP0005367_renal/urinary_system_phenotyp0.73641013
75MP0008469_abnormal_protein_level0.73540980
76MP0009785_altered_susceptibility_to0.68745440
77MP0001485_abnormal_pinna_reflex0.68452959
78MP0001764_abnormal_homeostasis0.67351281
79MP0005319_abnormal_enzyme/_coenzyme0.67083920
80MP0005166_decreased_susceptibility_to0.67012417
81MP0002166_altered_tumor_susceptibility0.66873324
82MP0003724_increased_susceptibility_to0.64606542
83MP0000465_gastrointestinal_hemorrhage0.63966753
84MP0003879_abnormal_hair_cell0.63794752
85MP0005666_abnormal_adipose_tissue0.62616572
86MP0003638_abnormal_response/metabolism_0.61259677
87MP0000604_amyloidosis0.60820010
88MP0006138_congestive_heart_failure0.60222802
89MP0003329_amyloid_beta_deposits0.59036208
90MP0003950_abnormal_plasma_membrane0.58880283
91MP0006082_CNS_inflammation0.58680150
92MP0003453_abnormal_keratinocyte_physiol0.58193349
93MP0009765_abnormal_xenobiotic_induced0.58012638
94MP0009384_cardiac_valve_regurgitation0.56869182
95MP0009642_abnormal_blood_homeostasis0.56731811
96MP0005174_abnormal_tail_pigmentation0.56466012
97MP0001765_abnormal_ion_homeostasis0.56389607
98MP0009115_abnormal_fat_cell0.56316530
99MP0001835_abnormal_antigen_presentation0.55926900
100MP0005025_abnormal_response_to0.55268316
101MP0002136_abnormal_kidney_physiology0.55209035
102MP0005636_abnormal_mineral_homeostasis0.54136614
103MP0005376_homeostasis/metabolism_phenot0.53062660
104MP0001216_abnormal_epidermal_layer0.52289682
105MP0000678_abnormal_parathyroid_gland0.51561661
106MP0003953_abnormal_hormone_level0.51554665
107MP0005387_immune_system_phenotype0.50344559
108MP0001790_abnormal_immune_system0.50344559
109MP0005584_abnormal_enzyme/coenzyme_acti0.48248970
110MP0003436_decreased_susceptibility_to0.46855415
111MP0002896_abnormal_bone_mineralization0.46280164
112MP0003315_abnormal_perineum_morphology0.45272946
113MP0001191_abnormal_skin_condition0.44679537
114MP0009333_abnormal_splenocyte_physiolog0.44426622
115MP0005058_abnormal_lysosome_morphology0.44221859
116MP0000579_abnormal_nail_morphology0.43966585
117MP0002138_abnormal_hepatobiliary_system0.43940625
118MP0005165_increased_susceptibility_to0.43635240
119MP0000427_abnormal_hair_cycle0.43211615
120MP0003656_abnormal_erythrocyte_physiolo0.42202134
121MP0000230_abnormal_systemic_arterial0.42114306
122MP0002971_abnormal_brown_adipose0.41474150
123MP0002078_abnormal_glucose_homeostasis0.38938501
124MP0009764_decreased_sensitivity_to0.38870769
125MP0000249_abnormal_blood_vessel0.37825957
126MP0001881_abnormal_mammary_gland0.37760628
127MP0005334_abnormal_fat_pad0.36837843
128MP0000598_abnormal_liver_morphology0.34766580
129MP0000470_abnormal_stomach_morphology0.34637900
130MP0008873_increased_physiological_sensi0.33989217
131MP0000377_abnormal_hair_follicle0.32310393
132MP0005023_abnormal_wound_healing0.31980991

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)8.38233609
2Acanthocytosis (HP:0001927)7.94960425
3Hypobetalipoproteinemia (HP:0003563)7.93831400
4Abnormality of glutamine family amino acid metabolism (HP:0010902)7.43353035
5Autoimmune thrombocytopenia (HP:0001973)6.84728409
6Abnormality of proline metabolism (HP:0010907)5.78696351
7Hydroxyprolinuria (HP:0003080)5.78696351
8Malnutrition (HP:0004395)5.76909192
9Cupped ribs (HP:0000887)5.06052967
10Conjugated hyperbilirubinemia (HP:0002908)5.05435411
11Autoimmune hemolytic anemia (HP:0001890)4.99685963
12Pigmentary retinal degeneration (HP:0001146)4.99162530
13Hypolipoproteinemia (HP:0010981)4.68578834
14Right ventricular cardiomyopathy (HP:0011663)4.68391050
15Poikilocytosis (HP:0004447)4.52925034
16Increased IgE level (HP:0003212)4.39045791
17Widely patent fontanelles and sutures (HP:0004492)4.27288460
18Mesangial abnormality (HP:0001966)4.21733840
19Systemic lupus erythematosus (HP:0002725)4.13258628
20Facial shape deformation (HP:0011334)4.07702420
21Potter facies (HP:0002009)4.07702420
22Fat malabsorption (HP:0002630)4.07478832
23Proximal tubulopathy (HP:0000114)3.82093198
24Hyperglycinuria (HP:0003108)3.64226253
25Abnormality of B cell number (HP:0010975)3.63670652
26B lymphocytopenia (HP:0010976)3.63670652
27Chronic diarrhea (HP:0002028)3.63522169
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.63105916
29Xanthomatosis (HP:0000991)3.49653806
30Abdominal distention (HP:0003270)3.44350266
31Glycosuria (HP:0003076)3.42448617
32Abnormality of urine glucose concentration (HP:0011016)3.42448617
33Severe combined immunodeficiency (HP:0004430)3.33315520
34Abnormal glucose tolerance (HP:0001952)3.19808574
35Increased purine levels (HP:0004368)3.18514066
36Hyperuricemia (HP:0002149)3.18514066
37Steatorrhea (HP:0002570)3.07173147
38Gastrointestinal dysmotility (HP:0002579)3.02541935
39Combined immunodeficiency (HP:0005387)2.99838500
40Posterior subcapsular cataract (HP:0007787)2.98667660
41Reticulocytosis (HP:0001923)2.95936044
42Decreased circulating renin level (HP:0003351)2.94806733
43Thyroiditis (HP:0100646)2.94369324
44Dehydration (HP:0001944)2.93457462
45Alkalosis (HP:0001948)2.90561801
46Wide cranial sutures (HP:0010537)2.82992929
47Hypercholesterolemia (HP:0003124)2.78446106
48Nephrolithiasis (HP:0000787)2.77424723
49Hyperactive renin-angiotensin system (HP:0000841)2.77028728
50Increased mean platelet volume (HP:0011877)2.69966566
51Metabolic alkalosis (HP:0200114)2.67010565
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.65085424
53Eczematoid dermatitis (HP:0000976)2.62191656
54Abnormality of the vitamin B12 metabolism (HP:0004341)2.59040413
55Polycythemia (HP:0001901)2.55839889
56Enlarged epiphyses (HP:0010580)2.52879102
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52411236
58Abnormality of glycine metabolism (HP:0010895)2.48652035
59Abnormality of serine family amino acid metabolism (HP:0010894)2.48652035
60Abnormality of purine metabolism (HP:0004352)2.47772474
61Epidermoid cyst (HP:0200040)2.45845187
62Abnormality of vitamin B metabolism (HP:0004340)2.41091473
63Delayed epiphyseal ossification (HP:0002663)2.39013179
64Focal segmental glomerulosclerosis (HP:0000097)2.36860207
65Metabolic acidosis (HP:0001942)2.36549247
66Abnormal platelet volume (HP:0011876)2.35989042
67Hyperphosphaturia (HP:0003109)2.35694044
68Abnormal gallbladder physiology (HP:0012438)2.34367671
69Cholecystitis (HP:0001082)2.34367671
70Hypotension (HP:0002615)2.32365039
71Gout (HP:0001997)2.32272092
72Mildly elevated creatine phosphokinase (HP:0008180)2.29465870
73Intrahepatic cholestasis (HP:0001406)2.28635932
74Abnormality of renin-angiotensin system (HP:0000847)2.25421881
75Abnormality of the costochondral junction (HP:0000919)2.25098825
76Palpitations (HP:0001962)2.22151422
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.21656668
78Abnormality of the gastric mucosa (HP:0004295)2.19824379
79Subcapsular cataract (HP:0000523)2.19731085
80Abnormality of magnesium homeostasis (HP:0004921)2.17791112
81Abnormality of pyrimidine metabolism (HP:0004353)2.16511663
82Abnormality of eosinophils (HP:0001879)2.13015765
83Villous atrophy (HP:0011473)2.11137632
84Abnormality of small intestinal villus morphology (HP:0011472)2.11137632
85Abnormality of vitamin metabolism (HP:0100508)2.09118720
86Cerebral palsy (HP:0100021)2.08996894
87Hemorrhage of the eye (HP:0011885)2.08990703
88Woolly hair (HP:0002224)2.08445841
89Progressive sensorineural hearing impairment (HP:0000408)2.07554586
90Protuberant abdomen (HP:0001538)2.07252831
91Dicarboxylic aciduria (HP:0003215)2.06927507
92Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06927507
93Nausea (HP:0002018)2.06451903
94Renal tubular acidosis (HP:0001947)2.04679979
95Pili torti (HP:0003777)2.04259028
96Rectal prolapse (HP:0002035)2.03996184
97Eosinophilia (HP:0001880)2.02715561
98Irritability (HP:0000737)2.01560641
99Abnormal biliary tract morphology (HP:0012440)2.01107111
100Hyperphosphatemia (HP:0002905)2.00781516
101Myopathic facies (HP:0002058)2.00523557
102Glomerulonephritis (HP:0000099)1.99085071
103Abnormality of nucleobase metabolism (HP:0010932)1.98888960
104Abnormal urine phosphate concentration (HP:0012599)1.98281754
105Confusion (HP:0001289)1.94811729
106Flat acetabular roof (HP:0003180)1.94552430
107Goiter (HP:0000853)1.93990108
108Hyperbilirubinemia (HP:0002904)1.93681943
109Congenital sensorineural hearing impairment (HP:0008527)1.91556949
110Syncope (HP:0001279)1.91064405
111Gingivitis (HP:0000230)1.90040122
112Milia (HP:0001056)1.89043076
113Hyperparathyroidism (HP:0000843)1.88534012
114Amyloidosis (HP:0011034)1.87410373
115Hypoalbuminemia (HP:0003073)1.85810062
116Abnormal albumin level (HP:0012116)1.85810062
117Hyperammonemia (HP:0001987)1.85677339
118Growth hormone excess (HP:0000845)1.85622424
119Renal tubular dysfunction (HP:0000124)1.85161567
120Megaloblastic anemia (HP:0001889)1.84331329
121Abnormality of complement system (HP:0005339)1.83461274
122Pustule (HP:0200039)1.81225789
123Abnormality of the 1st metacarpal (HP:0010009)1.80155135
124Complement deficiency (HP:0004431)1.79951074
125Cheilitis (HP:0100825)1.77326644
126Nephritis (HP:0000123)1.77210217
127Glomerulosclerosis (HP:0000096)1.77001082
128Multiple lipomas (HP:0001012)1.76844037
129Progressive hearing impairment (HP:0001730)1.74995493
130Abnormal enzyme/coenzyme activity (HP:0012379)1.73677178
131Granulocytopenia (HP:0001913)1.73530980
132Thin bony cortex (HP:0002753)1.73452945
133White forelock (HP:0002211)1.73429686
134Pancreatitis (HP:0001733)1.72933916
135Abnormality of alkaline phosphatase activity (HP:0004379)1.72874638
136Abnormal platelet function (HP:0011869)1.72696629
137Impaired platelet aggregation (HP:0003540)1.72696629
138Nonimmune hydrops fetalis (HP:0001790)1.72415955
139Lethargy (HP:0001254)1.71411922
140Symptomatic seizures (HP:0011145)1.70630226
141Patchy hypopigmentation of hair (HP:0011365)1.70512496
142Alopecia of scalp (HP:0002293)1.69478395
143Peripheral demyelination (HP:0011096)1.68741611
144Hypophosphatemia (HP:0002148)1.64571594
145Hypocalcemia (HP:0002901)1.63875432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.91168238
2FRK6.13938828
3MST45.58052434
4LMTK24.82212554
5MST1R4.57815196
6GRK63.81040752
7PRKG23.47879693
8NME13.27838243
9EPHA22.93730705
10AKT32.81260441
11RIPK12.61140633
12MAP3K102.56814340
13MAP3K22.32277679
14STK392.28190280
15NUAK12.19479791
16PTK62.18579192
17ERN12.13216752
18MAP2K22.10687833
19OXSR11.90894164
20EPHA31.72524661
21MET1.70869550
22EPHB21.70368165
23TESK21.63570975
24TESK11.51111529
25PIK3CG1.43264714
26STK101.34643610
27TAOK11.29114847
28STK241.23714981
29EPHA41.22265153
30BMX1.17199068
31KSR21.13840302
32DDR21.08539538
33EPHB11.08365387
34FGFR31.04053836
35MAP3K111.00902798
36NLK1.00174594
37FER1.00171106
38PRKCI0.97738610
39MAP3K80.95841839
40PTK20.95478592
41MAP2K60.92391541
42MATK0.91927554
43RIPK40.91809969
44PRPF4B0.82311715
45PIM10.81823366
46MAP3K70.81721187
47PAK40.80331342
48MUSK0.79040310
49PRKAA20.77658711
50MYLK0.77066006
51LATS10.73827397
52BMPR20.72548476
53CASK0.72285985
54CDC42BPA0.72202713
55MAP3K90.71856249
56MAP3K10.70821155
57TBK10.70524340
58TTK0.69559032
59MAP2K10.69551474
60ERBB20.69285384
61PBK0.67859331
62SCYL20.66324228
63PRKCZ0.65953979
64CDK190.65945690
65MAP3K30.65863536
66IRAK10.61764440
67TAOK30.61648154
68MAPK110.59317270
69JAK10.54224426
70ICK0.52170630
71PDPK10.52006576
72LIMK10.51769389
73LRRK20.51400126
74PIM20.50951766
75ERBB40.50312327
76ABL20.46042184
77YES10.45281782
78PAK30.43186470
79MAP3K120.41947052
80TYK20.41422099
81JAK20.40237545
82PRKAA10.36954967
83DYRK1B0.35426036
84CSF1R0.35254178
85IKBKE0.34780824
86MAP4K10.34139711
87CSK0.33780871
88PIK3CA0.33216055
89DMPK0.32540117
90NEK60.32532634
91MAPKAPK20.32392685
92BTK0.32083634
93PDK10.31947504
94PDK20.31859443
95SRC0.30908353
96SYK0.30058456
97TEC0.29774446
98PRKCA0.29771844
99CAMK2B0.27614166
100PKN20.27241381
101CDK60.26752084
102CSNK1A10.26154615
103PRKACG0.25183714
104PAK10.24447719
105FYN0.24178950
106ZAP700.24165678
107FGR0.24086156
108TNIK0.23914305
109PDGFRA0.23024117
110PAK20.22417052
111PRKCQ0.22259360
112PRKCD0.22141819
113TYRO30.20737415
114AKT20.20513628
115PRKACA0.20292941
116ROCK10.19834266
117STK30.19178868
118GRK10.18829530
119DAPK20.18333890
120LYN0.18230390
121IRAK40.18116643
122IGF1R0.16602610
123LCK0.16431407
124ARAF0.15447806
125CAMK2D0.13807343
126MELK0.13785508
127GSK3A0.13460619
128FGFR40.13075471
129CDK50.12890471
130CAMK2G0.12674153
131IRAK30.11759624
132BRAF0.10997966
133ITK0.10490721
134RET0.09573985
135STK110.08639174
136MAPK40.07461681
137PRKCB0.06737181

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.78854034
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.93584894
3Renin-angiotensin system_Homo sapiens_hsa046144.91456237
4Mineral absorption_Homo sapiens_hsa049784.10141049
5* Vitamin digestion and absorption_Homo sapiens_hsa049773.18940906
6Caffeine metabolism_Homo sapiens_hsa002323.06312506
7Carbohydrate digestion and absorption_Homo sapiens_hsa049732.98216230
8Galactose metabolism_Homo sapiens_hsa000522.93703560
9Starch and sucrose metabolism_Homo sapiens_hsa005002.72541244
10Folate biosynthesis_Homo sapiens_hsa007902.41565366
11Protein digestion and absorption_Homo sapiens_hsa049742.37334834
12Bile secretion_Homo sapiens_hsa049761.95100667
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.92798447
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.92677602
15Fructose and mannose metabolism_Homo sapiens_hsa000511.81518610
16Sulfur metabolism_Homo sapiens_hsa009201.80211252
17Histidine metabolism_Homo sapiens_hsa003401.64838488
18PPAR signaling pathway_Homo sapiens_hsa033201.50477567
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49552136
20Glycerolipid metabolism_Homo sapiens_hsa005611.38504117
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.37043677
22Glutathione metabolism_Homo sapiens_hsa004801.34628684
23Sphingolipid metabolism_Homo sapiens_hsa006001.31373606
24Arginine biosynthesis_Homo sapiens_hsa002201.23627016
25Asthma_Homo sapiens_hsa053101.17304571
26Tryptophan metabolism_Homo sapiens_hsa003801.15575537
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13209335
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12895281
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09726393
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09148817
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08678390
32Nitrogen metabolism_Homo sapiens_hsa009101.06818129
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02194398
34Fatty acid degradation_Homo sapiens_hsa000711.01479233
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01459661
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92622152
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92403383
38Arginine and proline metabolism_Homo sapiens_hsa003300.90823958
39Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86151897
40ABC transporters_Homo sapiens_hsa020100.80906728
41Allograft rejection_Homo sapiens_hsa053300.77036708
42Autoimmune thyroid disease_Homo sapiens_hsa053200.71403169
43Thyroid hormone synthesis_Homo sapiens_hsa049180.69890306
44Pyruvate metabolism_Homo sapiens_hsa006200.69688601
45Glycerophospholipid metabolism_Homo sapiens_hsa005640.69083421
46Graft-versus-host disease_Homo sapiens_hsa053320.67912231
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66203319
48Carbon metabolism_Homo sapiens_hsa012000.66155619
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.64178963
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64157801
51Staphylococcus aureus infection_Homo sapiens_hsa051500.62809458
52Pentose phosphate pathway_Homo sapiens_hsa000300.60094823
53Fatty acid biosynthesis_Homo sapiens_hsa000610.56533621
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51660363
55Retinol metabolism_Homo sapiens_hsa008300.51592933
56Type II diabetes mellitus_Homo sapiens_hsa049300.51414033
57Chemical carcinogenesis_Homo sapiens_hsa052040.51022893
58Type I diabetes mellitus_Homo sapiens_hsa049400.50789181
59Tight junction_Homo sapiens_hsa045300.49252123
60beta-Alanine metabolism_Homo sapiens_hsa004100.44803483
61Linoleic acid metabolism_Homo sapiens_hsa005910.44649095
62Arachidonic acid metabolism_Homo sapiens_hsa005900.42218169
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41399342
64Pancreatic secretion_Homo sapiens_hsa049720.38013469
65Biosynthesis of amino acids_Homo sapiens_hsa012300.37335597
66Fatty acid metabolism_Homo sapiens_hsa012120.36785409
67Other glycan degradation_Homo sapiens_hsa005110.34950419
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34277811
69Tyrosine metabolism_Homo sapiens_hsa003500.34236016
70Gastric acid secretion_Homo sapiens_hsa049710.33425906
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32600962
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31736574
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.31277008
74African trypanosomiasis_Homo sapiens_hsa051430.31146965
75Antigen processing and presentation_Homo sapiens_hsa046120.30681755
76Peroxisome_Homo sapiens_hsa041460.27222466
77Ether lipid metabolism_Homo sapiens_hsa005650.26931829
78Steroid biosynthesis_Homo sapiens_hsa001000.25225079
79Thyroid cancer_Homo sapiens_hsa052160.23785449
80Leishmaniasis_Homo sapiens_hsa051400.22767111
81Salmonella infection_Homo sapiens_hsa051320.22681815
82Metabolic pathways_Homo sapiens_hsa011000.22281481
83Bladder cancer_Homo sapiens_hsa052190.22237446
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.22180295
85Renin secretion_Homo sapiens_hsa049240.22074338
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.21929596
87Cocaine addiction_Homo sapiens_hsa050300.21710358
88Sulfur relay system_Homo sapiens_hsa041220.20640014
89Hepatitis C_Homo sapiens_hsa051600.19244897
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.19013123
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18856311
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18586961
93GnRH signaling pathway_Homo sapiens_hsa049120.17965707
94Insulin secretion_Homo sapiens_hsa049110.16632480
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16530551
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.16108002
97Butanoate metabolism_Homo sapiens_hsa006500.15301454
98Glucagon signaling pathway_Homo sapiens_hsa049220.15072568
99Selenocompound metabolism_Homo sapiens_hsa004500.14299624
100Salivary secretion_Homo sapiens_hsa049700.13353563
101Fatty acid elongation_Homo sapiens_hsa000620.12583053
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.12501701
103Adherens junction_Homo sapiens_hsa045200.11058462
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10457648
105Lysine degradation_Homo sapiens_hsa003100.10435391
106Pertussis_Homo sapiens_hsa051330.10160222
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.10130217
108Viral myocarditis_Homo sapiens_hsa054160.09484892
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09146368
110Insulin resistance_Homo sapiens_hsa049310.07826924
111Serotonergic synapse_Homo sapiens_hsa047260.07750046
112Phenylalanine metabolism_Homo sapiens_hsa003600.06847353
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.06308231
114Long-term depression_Homo sapiens_hsa047300.05018275
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.04759694
116Amphetamine addiction_Homo sapiens_hsa050310.04723589
117VEGF signaling pathway_Homo sapiens_hsa043700.04230139
118Toxoplasmosis_Homo sapiens_hsa051450.03939586
119Hematopoietic cell lineage_Homo sapiens_hsa046400.03567678
120Gap junction_Homo sapiens_hsa045400.01780419
121Propanoate metabolism_Homo sapiens_hsa006400.01579604
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.01026202
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.00206245
124Vibrio cholerae infection_Homo sapiens_hsa05110-0.0234572
125Choline metabolism in cancer_Homo sapiens_hsa05231-0.0201401
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0009882

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