Rank | Gene Set | Z-score |
---|---|---|
1 | exogenous drug catabolic process (GO:0042738) | 8.68617125 |
2 | regulation of fibrinolysis (GO:0051917) | 8.23339322 |
3 | negative regulation of fibrinolysis (GO:0051918) | 8.16414848 |
4 | drug catabolic process (GO:0042737) | 8.13690224 |
5 | epoxygenase P450 pathway (GO:0019373) | 7.56599857 |
6 | glyoxylate metabolic process (GO:0046487) | 7.39631929 |
7 | L-phenylalanine catabolic process (GO:0006559) | 7.32450240 |
8 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 7.32450240 |
9 | omega-hydroxylase P450 pathway (GO:0097267) | 6.84213725 |
10 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 6.77755661 |
11 | L-phenylalanine metabolic process (GO:0006558) | 6.77755661 |
12 | regulation of protein activation cascade (GO:2000257) | 6.74750340 |
13 | complement activation, alternative pathway (GO:0006957) | 6.55617499 |
14 | urea metabolic process (GO:0019627) | 6.53672894 |
15 | fibrinolysis (GO:0042730) | 6.39505297 |
16 | regulation of complement activation (GO:0030449) | 6.38419291 |
17 | negative regulation of sterol transport (GO:0032372) | 6.24105535 |
18 | negative regulation of cholesterol transport (GO:0032375) | 6.24105535 |
19 | protein carboxylation (GO:0018214) | 6.17217099 |
20 | peptidyl-glutamic acid carboxylation (GO:0017187) | 6.17217099 |
21 | ethanol oxidation (GO:0006069) | 6.16694672 |
22 | nitrogen cycle metabolic process (GO:0071941) | 5.96290923 |
23 | cellular glucuronidation (GO:0052695) | 5.82848768 |
24 | urea cycle (GO:0000050) | 5.65233809 |
25 | drug metabolic process (GO:0017144) | 5.61085469 |
26 | uronic acid metabolic process (GO:0006063) | 5.55725860 |
27 | glucuronate metabolic process (GO:0019585) | 5.55725860 |
28 | blood coagulation, intrinsic pathway (GO:0007597) | 5.54974235 |
29 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 5.38664647 |
30 | regulation of triglyceride catabolic process (GO:0010896) | 5.34172230 |
31 | phospholipid efflux (GO:0033700) | 5.31580427 |
32 | regulation of plasminogen activation (GO:0010755) | 5.29843550 |
33 | aromatic amino acid family catabolic process (GO:0009074) | 5.26484851 |
34 | phenylpropanoid metabolic process (GO:0009698) | 5.12038789 |
35 | oxidative demethylation (GO:0070989) | 5.11208621 |
36 | bile acid biosynthetic process (GO:0006699) | 5.00788517 |
37 | serine family amino acid catabolic process (GO:0009071) | 4.99094663 |
38 | ethanol metabolic process (GO:0006067) | 4.89914149 |
39 | high-density lipoprotein particle remodeling (GO:0034375) | 4.88320978 |
40 | negative regulation of blood coagulation (GO:0030195) | 4.82537373 |
41 | negative regulation of hemostasis (GO:1900047) | 4.82537373 |
42 | protein activation cascade (GO:0072376) | 4.81739600 |
43 | glycine metabolic process (GO:0006544) | 4.79300642 |
44 | protein-lipid complex remodeling (GO:0034368) | 4.78244750 |
45 | macromolecular complex remodeling (GO:0034367) | 4.78244750 |
46 | plasma lipoprotein particle remodeling (GO:0034369) | 4.78244750 |
47 | bile acid metabolic process (GO:0008206) | 4.77832639 |
48 | complement activation, classical pathway (GO:0006958) | 4.72364474 |
49 | acylglycerol homeostasis (GO:0055090) | 4.66652257 |
50 | triglyceride homeostasis (GO:0070328) | 4.66652257 |
51 | S-adenosylmethionine metabolic process (GO:0046500) | 4.61995718 |
52 | regulation of cholesterol esterification (GO:0010872) | 4.58353507 |
53 | cholesterol efflux (GO:0033344) | 4.57634208 |
54 | complement activation (GO:0006956) | 4.56474269 |
55 | amino-acid betaine metabolic process (GO:0006577) | 4.55875421 |
56 | bile acid and bile salt transport (GO:0015721) | 4.51321891 |
57 | very-low-density lipoprotein particle assembly (GO:0034379) | 4.48515100 |
58 | positive regulation of triglyceride lipase activity (GO:0061365) | 4.44158245 |
59 | positive regulation of lipoprotein lipase activity (GO:0051006) | 4.44158245 |
60 | negative regulation of coagulation (GO:0050819) | 4.36762660 |
61 | reverse cholesterol transport (GO:0043691) | 4.27990022 |
62 | alkaloid metabolic process (GO:0009820) | 4.26719452 |
63 | negative regulation of wound healing (GO:0061045) | 4.25093557 |
64 | response to mercury ion (GO:0046689) | 4.24810180 |
65 | positive regulation of blood coagulation (GO:0030194) | 4.23267657 |
66 | positive regulation of hemostasis (GO:1900048) | 4.23267657 |
67 | negative regulation of lipase activity (GO:0060192) | 4.22406349 |
68 | acute-phase response (GO:0006953) | 4.18936225 |
69 | regulation of humoral immune response (GO:0002920) | 4.16871963 |
70 | fat-soluble vitamin biosynthetic process (GO:0042362) | 4.14763383 |
71 | tyrosine metabolic process (GO:0006570) | 4.07637238 |
72 | intestinal cholesterol absorption (GO:0030299) | 4.05930123 |
73 | negative regulation of protein activation cascade (GO:2000258) | 4.05356654 |
74 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 3.93129799 |
75 | positive regulation of coagulation (GO:0050820) | 3.87355677 |
76 | imidazole-containing compound metabolic process (GO:0052803) | 3.86101999 |
77 | plasma lipoprotein particle assembly (GO:0034377) | 3.81775686 |
78 | plasma lipoprotein particle clearance (GO:0034381) | 3.74352796 |
79 | plasma lipoprotein particle organization (GO:0071827) | 3.73189286 |
80 | arginine metabolic process (GO:0006525) | 3.70485716 |
81 | serine family amino acid metabolic process (GO:0009069) | 3.68174581 |
82 | flavonoid metabolic process (GO:0009812) | 3.62497419 |
83 | hormone catabolic process (GO:0042447) | 3.57293776 |
84 | glutamate metabolic process (GO:0006536) | 3.57157710 |
85 | regulation of lipoprotein particle clearance (GO:0010984) | 3.56191732 |
86 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 3.52299334 |
87 | protein-lipid complex subunit organization (GO:0071825) | 3.52171948 |
88 | alpha-amino acid catabolic process (GO:1901606) | 3.50609587 |
89 | disruption of cells of other organism involved in symbiotic interaction (GO:0051818) | 3.44160786 |
90 | killing of cells in other organism involved in symbiotic interaction (GO:0051883) | 3.44160786 |
91 | indole-containing compound catabolic process (GO:0042436) | 3.43404505 |
92 | indolalkylamine catabolic process (GO:0046218) | 3.43404505 |
93 | tryptophan catabolic process (GO:0006569) | 3.43404505 |
94 | negative regulation of complement activation (GO:0045916) | 3.43335517 |
95 | protein-lipid complex assembly (GO:0065005) | 3.42289855 |
96 | negative regulation of lipid transport (GO:0032369) | 3.40443497 |
97 | positive regulation of lipid catabolic process (GO:0050996) | 3.39141747 |
98 | polyketide metabolic process (GO:0030638) | 3.38126753 |
99 | doxorubicin metabolic process (GO:0044598) | 3.38126753 |
100 | daunorubicin metabolic process (GO:0044597) | 3.38126753 |
Rank | Gene Set | Z-score |
---|---|---|
1 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 6.42066889 |
2 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 5.55114485 |
3 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 5.51867627 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 5.09790103 |
5 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.64370784 |
6 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 4.40279881 |
7 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 4.26804200 |
8 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 3.74091918 |
9 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.53054898 |
10 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.26457012 |
11 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.17194956 |
12 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 2.13825923 |
13 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 2.10110813 |
14 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.05862221 |
15 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 10.1153111 |
16 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.93845247 |
17 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.87366492 |
18 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.74409135 |
19 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.53858221 |
20 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.47127145 |
21 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.41794358 |
22 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.40909784 |
23 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.37163108 |
24 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.30258117 |
25 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.29959302 |
26 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.15864476 |
27 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.14481019 |
28 | GATA6_25053715_ChIP-Seq_YYC3_Human | 1.13190378 |
29 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.10553280 |
30 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.09946733 |
31 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.08946760 |
32 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.07589460 |
33 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.05143497 |
34 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.03999128 |
35 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.01139101 |
36 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.01120851 |
37 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.98754939 |
38 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.98275865 |
39 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.98274793 |
40 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.98172483 |
41 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.97169859 |
42 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.96136260 |
43 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.95553695 |
44 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.95329362 |
45 | GATA1_19941826_ChIP-Seq_K562_Human | 0.94503504 |
46 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.93148225 |
47 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.92567890 |
48 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.88846750 |
49 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.85941484 |
50 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.85407636 |
51 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.84409644 |
52 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.82732390 |
53 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.82146087 |
54 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.81093756 |
55 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.80342827 |
56 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.79001857 |
57 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.78266813 |
58 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.78060878 |
59 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.77945049 |
60 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.77941702 |
61 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.75952835 |
62 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.74744836 |
63 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.73307318 |
64 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.73191598 |
65 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.72753218 |
66 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.72739060 |
67 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.72656328 |
68 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 0.72639367 |
69 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.72569992 |
70 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.72496165 |
71 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.72279202 |
72 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.71663033 |
73 | SA1_27219007_Chip-Seq_Bcells_Human | 0.71660510 |
74 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.71375751 |
75 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.71326527 |
76 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.70901485 |
77 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.70704301 |
78 | VDR_24763502_ChIP-Seq_THP-1_Human | 0.69879840 |
79 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.69714764 |
80 | GATA2_19941826_ChIP-Seq_K562_Human | 0.69627013 |
81 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.69128148 |
82 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.68866413 |
83 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.68498394 |
84 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.68410437 |
85 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.68232193 |
86 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.67170824 |
87 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.66785458 |
88 | P68_20966046_ChIP-Seq_HELA_Human | 0.66305123 |
89 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.66285318 |
90 | MAF_26560356_Chip-Seq_TH1_Human | 0.66130093 |
91 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.65845120 |
92 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.65477639 |
93 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.65470664 |
94 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.65232575 |
95 | P300_27268052_Chip-Seq_Bcells_Human | 0.64785159 |
96 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.64168166 |
97 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.64126056 |
98 | SPI1_23127762_ChIP-Seq_K562_Human | 0.63873205 |
99 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.63642333 |
100 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.63160455 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 9.31600626 |
2 | MP0005360_urolithiasis | 6.22055263 |
3 | MP0005085_abnormal_gallbladder_physiolo | 5.63750983 |
4 | MP0005365_abnormal_bile_salt | 5.52354983 |
5 | MP0003195_calcinosis | 4.91014253 |
6 | MP0008875_abnormal_xenobiotic_pharmacok | 4.67780431 |
7 | MP0002138_abnormal_hepatobiliary_system | 4.10346783 |
8 | MP0003252_abnormal_bile_duct | 3.83763091 |
9 | MP0001666_abnormal_nutrient_absorption | 3.41062494 |
10 | MP0009840_abnormal_foam_cell | 3.03914414 |
11 | MP0003868_abnormal_feces_composition | 2.90158421 |
12 | MP0010329_abnormal_lipoprotein_level | 2.85958819 |
13 | MP0005332_abnormal_amino_acid | 2.38293431 |
14 | MP0003191_abnormal_cellular_cholesterol | 2.34236300 |
15 | MP0009697_abnormal_copulation | 2.15410673 |
16 | MP0003806_abnormal_nucleotide_metabolis | 1.99090256 |
17 | MP0000609_abnormal_liver_physiology | 1.94142506 |
18 | MP0005451_abnormal_body_composition | 1.91156304 |
19 | MP0002876_abnormal_thyroid_physiology | 1.74877530 |
20 | MP0002118_abnormal_lipid_homeostasis | 1.72209760 |
21 | MP0004019_abnormal_vitamin_homeostasis | 1.48948250 |
22 | MP0001764_abnormal_homeostasis | 1.48079538 |
23 | MP0002132_abnormal_respiratory_system | 1.47876104 |
24 | MP0010368_abnormal_lymphatic_system | 1.40141086 |
25 | MP0009643_abnormal_urine_homeostasis | 1.34158808 |
26 | MP0003656_abnormal_erythrocyte_physiolo | 1.33686173 |
27 | MP0005319_abnormal_enzyme/_coenzyme | 1.21818989 |
28 | MP0005408_hypopigmentation | 1.17272937 |
29 | MP0000598_abnormal_liver_morphology | 1.07681987 |
30 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.07603826 |
31 | MP0005464_abnormal_platelet_physiology | 1.05112455 |
32 | MP0008469_abnormal_protein_level | 0.99468616 |
33 | MP0001661_extended_life_span | 0.99096908 |
34 | MP0003436_decreased_susceptibility_to | 0.98658029 |
35 | MP0005058_abnormal_lysosome_morphology | 0.96196526 |
36 | MP0005636_abnormal_mineral_homeostasis | 0.93735490 |
37 | MP0009642_abnormal_blood_homeostasis | 0.92356090 |
38 | MP0002971_abnormal_brown_adipose | 0.90153937 |
39 | MP0005670_abnormal_white_adipose | 0.90032361 |
40 | MP0003303_peritoneal_inflammation | 0.88616887 |
41 | MP0009763_increased_sensitivity_to | 0.87269914 |
42 | MP0005376_homeostasis/metabolism_phenot | 0.81435374 |
43 | MP0001915_intracranial_hemorrhage | 0.79731339 |
44 | MP0003300_gastrointestinal_ulcer | 0.79672698 |
45 | MP0009785_altered_susceptibility_to | 0.78256395 |
46 | MP0003879_abnormal_hair_cell | 0.75855318 |
47 | MP0003186_abnormal_redox_activity | 0.74460317 |
48 | MP0009764_decreased_sensitivity_to | 0.74437673 |
49 | MP0000604_amyloidosis | 0.71035642 |
50 | MP0000685_abnormal_immune_system | 0.70226540 |
51 | MP0002168_other_aberrant_phenotype | 0.67211482 |
52 | MP0004043_abnormal_pH_regulation | 0.65845773 |
53 | MP0005535_abnormal_body_temperature | 0.65764876 |
54 | MP0010155_abnormal_intestine_physiology | 0.64504801 |
55 | MP0005395_other_phenotype | 0.63490959 |
56 | MP0001851_eye_inflammation | 0.63239961 |
57 | MP0002136_abnormal_kidney_physiology | 0.63147412 |
58 | MP0005023_abnormal_wound_healing | 0.61592964 |
59 | MP0005025_abnormal_response_to | 0.61575035 |
60 | MP0002078_abnormal_glucose_homeostasis | 0.60964132 |
61 | MP0001756_abnormal_urination | 0.60722137 |
62 | MP0005164_abnormal_response_to | 0.59563470 |
63 | MP0008874_decreased_physiological_sensi | 0.58891311 |
64 | MP0009053_abnormal_anal_canal | 0.58793489 |
65 | MP0004883_abnormal_blood_vessel | 0.57965676 |
66 | MP0000249_abnormal_blood_vessel | 0.57501140 |
67 | MP0005334_abnormal_fat_pad | 0.57012708 |
68 | MP0003172_abnormal_lysosome_physiology | 0.55675399 |
69 | MP0002249_abnormal_larynx_morphology | 0.55419107 |
70 | MP0002419_abnormal_innate_immunity | 0.54601221 |
71 | MP0001845_abnormal_inflammatory_respons | 0.53395288 |
72 | MP0003638_abnormal_response/metabolism_ | 0.52986598 |
73 | MP0009115_abnormal_fat_cell | 0.51804245 |
74 | MP0003690_abnormal_glial_cell | 0.50697835 |
75 | MP0005166_decreased_susceptibility_to | 0.48587323 |
76 | MP0004782_abnormal_surfactant_physiolog | 0.48304212 |
77 | MP0003705_abnormal_hypodermis_morpholog | 0.47354138 |
78 | MP0003075_altered_response_to | 0.46171363 |
79 | MP0006036_abnormal_mitochondrial_physio | 0.45428359 |
80 | MP0005266_abnormal_metabolism | 0.45192694 |
81 | MP0009333_abnormal_splenocyte_physiolog | 0.44154169 |
82 | MP0005220_abnormal_exocrine_pancreas | 0.41929327 |
83 | MP0002282_abnormal_trachea_morphology | 0.41458206 |
84 | MP0005448_abnormal_energy_balance | 0.40111563 |
85 | MP0008872_abnormal_physiological_respon | 0.40011877 |
86 | MP0000858_altered_metastatic_potential | 0.39458382 |
87 | MP0002970_abnormal_white_adipose | 0.39285155 |
88 | MP0004264_abnormal_extraembryonic_tissu | 0.38911083 |
89 | MP0001533_abnormal_skeleton_physiology | 0.38639392 |
90 | MP0001800_abnormal_humoral_immune | 0.37036104 |
91 | MP0005397_hematopoietic_system_phenotyp | 0.36927949 |
92 | MP0001545_abnormal_hematopoietic_system | 0.36927949 |
93 | MP0005666_abnormal_adipose_tissue | 0.35390442 |
94 | MP0005409_darkened_coat_color | 0.33849800 |
95 | MP0008260_abnormal_autophagy | 0.33777591 |
96 | MP0009765_abnormal_xenobiotic_induced | 0.33028447 |
97 | MP0005647_abnormal_sex_gland | 0.31811971 |
98 | MP0003953_abnormal_hormone_level | 0.31614447 |
99 | MP0003183_abnormal_peptide_metabolism | 0.30704037 |
100 | MP0002166_altered_tumor_susceptibility | 0.30676406 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Deep venous thrombosis (HP:0002625) | 9.54149231 |
2 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 9.38748555 |
3 | Prolonged partial thromboplastin time (HP:0003645) | 7.98977012 |
4 | Complement deficiency (HP:0004431) | 7.91700846 |
5 | Hypobetalipoproteinemia (HP:0003563) | 7.55178757 |
6 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 7.44887431 |
7 | Abnormality of complement system (HP:0005339) | 6.70056179 |
8 | Systemic lupus erythematosus (HP:0002725) | 6.29849942 |
9 | Joint hemorrhage (HP:0005261) | 5.85019609 |
10 | Hyperlipoproteinemia (HP:0010980) | 5.51472270 |
11 | Conjugated hyperbilirubinemia (HP:0002908) | 5.17118633 |
12 | Xanthomatosis (HP:0000991) | 4.81854595 |
13 | Glomerulonephritis (HP:0000099) | 4.77878337 |
14 | Hypolipoproteinemia (HP:0010981) | 4.45340014 |
15 | Abnormality of the common coagulation pathway (HP:0010990) | 4.41685814 |
16 | Abnormality of pyrimidine metabolism (HP:0004353) | 4.31258264 |
17 | Intrahepatic cholestasis (HP:0001406) | 4.06294833 |
18 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.98127620 |
19 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 3.91278241 |
20 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 3.81130715 |
21 | Hemorrhage of the eye (HP:0011885) | 3.66516962 |
22 | Nephritis (HP:0000123) | 3.66480937 |
23 | Spontaneous abortion (HP:0005268) | 3.51055579 |
24 | Abnormality of the intrinsic pathway (HP:0010989) | 3.47154619 |
25 | Fat malabsorption (HP:0002630) | 3.31721244 |
26 | Rickets (HP:0002748) | 3.12283303 |
27 | Hyperammonemia (HP:0001987) | 3.03373524 |
28 | Gingival bleeding (HP:0000225) | 3.03273016 |
29 | Hypercholesterolemia (HP:0003124) | 2.96741906 |
30 | Hypoalphalipoproteinemia (HP:0003233) | 2.94573747 |
31 | Vascular calcification (HP:0004934) | 2.84705234 |
32 | Mitral stenosis (HP:0001718) | 2.84456978 |
33 | Generalized aminoaciduria (HP:0002909) | 2.83046722 |
34 | Steatorrhea (HP:0002570) | 2.77515587 |
35 | Purpura (HP:0000979) | 2.76837936 |
36 | Delayed CNS myelination (HP:0002188) | 2.72111829 |
37 | Menorrhagia (HP:0000132) | 2.69707323 |
38 | Abnormality of methionine metabolism (HP:0010901) | 2.69457707 |
39 | Hyperglycinemia (HP:0002154) | 2.64150619 |
40 | Abnormality of nucleobase metabolism (HP:0010932) | 2.64019511 |
41 | Thrombophlebitis (HP:0004418) | 2.60594265 |
42 | Pulmonary embolism (HP:0002204) | 2.52820008 |
43 | Cardiovascular calcification (HP:0011915) | 2.52516373 |
44 | Abnormality of glycine metabolism (HP:0010895) | 2.44770925 |
45 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.44770925 |
46 | Osteomalacia (HP:0002749) | 2.44496932 |
47 | Cholecystitis (HP:0001082) | 2.34561345 |
48 | Abnormal gallbladder physiology (HP:0012438) | 2.34561345 |
49 | Epidermoid cyst (HP:0200040) | 2.33576438 |
50 | Hyperbilirubinemia (HP:0002904) | 2.29319981 |
51 | Hyperglycinuria (HP:0003108) | 2.26988970 |
52 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.26036298 |
53 | Alkalosis (HP:0001948) | 2.22373315 |
54 | Impaired platelet aggregation (HP:0003540) | 2.19372523 |
55 | Abnormal platelet function (HP:0011869) | 2.19372523 |
56 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.17406982 |
57 | Hepatocellular carcinoma (HP:0001402) | 2.13975860 |
58 | Abnormality of urine glucose concentration (HP:0011016) | 2.10141247 |
59 | Glycosuria (HP:0003076) | 2.10141247 |
60 | Hyperphosphaturia (HP:0003109) | 2.10001212 |
61 | Myocardial infarction (HP:0001658) | 2.04088120 |
62 | Abnormality of vitamin metabolism (HP:0100508) | 2.03073807 |
63 | Poikilocytosis (HP:0004447) | 2.02271377 |
64 | Epistaxis (HP:0000421) | 2.00514160 |
65 | Abnormality of iron homeostasis (HP:0011031) | 1.98794894 |
66 | Abnormality of serum amino acid levels (HP:0003112) | 1.97190548 |
67 | Metabolic acidosis (HP:0001942) | 1.96641568 |
68 | Elevated alkaline phosphatase (HP:0003155) | 1.95417572 |
69 | Abnormality of the Achilles tendon (HP:0005109) | 1.94537400 |
70 | Increased serum ferritin (HP:0003281) | 1.93919868 |
71 | Abnormality of proline metabolism (HP:0010907) | 1.93599332 |
72 | Hydroxyprolinuria (HP:0003080) | 1.93599332 |
73 | Reticulocytosis (HP:0001923) | 1.93383431 |
74 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.92746805 |
75 | Neonatal hypoglycemia (HP:0001998) | 1.91858583 |
76 | Hypophosphatemic rickets (HP:0004912) | 1.90605603 |
77 | Gout (HP:0001997) | 1.90487914 |
78 | Increased mean platelet volume (HP:0011877) | 1.89543471 |
79 | Abnormality of purine metabolism (HP:0004352) | 1.87368416 |
80 | Joint swelling (HP:0001386) | 1.86343579 |
81 | Polycythemia (HP:0001901) | 1.85470690 |
82 | Abnormality of alkaline phosphatase activity (HP:0004379) | 1.85395625 |
83 | Abnormal platelet volume (HP:0011876) | 1.84950148 |
84 | Cholelithiasis (HP:0001081) | 1.84821531 |
85 | Abnormal urine phosphate concentration (HP:0012599) | 1.81703728 |
86 | Gangrene (HP:0100758) | 1.81660098 |
87 | Hypochromic microcytic anemia (HP:0004840) | 1.81391596 |
88 | Reduced antithrombin III activity (HP:0001976) | 1.80455550 |
89 | Fair hair (HP:0002286) | 1.77249790 |
90 | Hypophosphatemia (HP:0002148) | 1.76248230 |
91 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.73826960 |
92 | Abnormal gallbladder morphology (HP:0012437) | 1.73535895 |
93 | Arthropathy (HP:0003040) | 1.73393742 |
94 | Hypochromic anemia (HP:0001931) | 1.71298886 |
95 | Potter facies (HP:0002009) | 1.70636523 |
96 | Facial shape deformation (HP:0011334) | 1.70636523 |
97 | Acanthocytosis (HP:0001927) | 1.70190011 |
98 | Ketosis (HP:0001946) | 1.66741794 |
99 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.64538034 |
100 | Mucopolysacchariduria (HP:0008155) | 1.64538034 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ERN1 | 6.53232732 |
2 | FGFR4 | 4.12134281 |
3 | TYK2 | 2.92041884 |
4 | TRIB3 | 2.91264577 |
5 | PRPF4B | 2.70641827 |
6 | CDK12 | 2.35821414 |
7 | FGFR3 | 2.27932967 |
8 | PIK3CG | 2.21893946 |
9 | RIPK1 | 2.01244679 |
10 | SIK1 | 1.94971007 |
11 | MST1R | 1.89089517 |
12 | MAP4K1 | 1.69391484 |
13 | ICK | 1.68499731 |
14 | TBK1 | 1.64508131 |
15 | MAPK11 | 1.61272047 |
16 | EPHB1 | 1.49947547 |
17 | RIPK4 | 1.49702499 |
18 | MAP3K14 | 1.38484685 |
19 | MAP2K3 | 1.37950690 |
20 | MAP3K1 | 1.36486289 |
21 | JAK1 | 1.34799635 |
22 | ZAP70 | 1.32497294 |
23 | TESK2 | 1.27840668 |
24 | TNK2 | 1.26447568 |
25 | PRKAA2 | 1.25824456 |
26 | MAP3K3 | 1.24216371 |
27 | EPHA3 | 1.22260847 |
28 | WNK3 | 1.18487811 |
29 | PDPK1 | 1.17105690 |
30 | MAP3K2 | 1.16930970 |
31 | KSR2 | 1.16896420 |
32 | BLK | 1.13929891 |
33 | IRAK3 | 1.10270200 |
34 | JAK3 | 1.07460562 |
35 | PTK6 | 1.07361517 |
36 | NLK | 1.05876008 |
37 | EEF2K | 1.05135543 |
38 | MAP3K13 | 1.03708630 |
39 | PRKACG | 1.01941361 |
40 | CDC42BPA | 1.01540403 |
41 | MAP3K7 | 1.00745036 |
42 | SMG1 | 1.00410485 |
43 | JAK2 | 0.94837590 |
44 | GRK6 | 0.93771886 |
45 | NTRK3 | 0.91037622 |
46 | TGFBR2 | 0.88093231 |
47 | PDGFRA | 0.87254403 |
48 | RET | 0.87040320 |
49 | NEK9 | 0.85280005 |
50 | MAP3K6 | 0.82501849 |
51 | CSF1R | 0.81979127 |
52 | PDK1 | 0.81311513 |
53 | ACVR1B | 0.79623805 |
54 | PKN2 | 0.76680684 |
55 | PIK3CA | 0.76486646 |
56 | RAF1 | 0.75030534 |
57 | CDK6 | 0.74826806 |
58 | SGK3 | 0.72033577 |
59 | PDK2 | 0.71120148 |
60 | CDK4 | 0.70858002 |
61 | MAP3K10 | 0.70758571 |
62 | MTOR | 0.67642376 |
63 | ERBB2 | 0.63406586 |
64 | LATS1 | 0.63386624 |
65 | WNK4 | 0.61737956 |
66 | IKBKE | 0.59301863 |
67 | BMX | 0.55775971 |
68 | PRKAA1 | 0.55618671 |
69 | SGK2 | 0.54735188 |
70 | BTK | 0.53906080 |
71 | MAPK7 | 0.52525054 |
72 | IGF1R | 0.52195675 |
73 | OXSR1 | 0.50902359 |
74 | IRAK4 | 0.50809212 |
75 | MYLK | 0.49730736 |
76 | MAPK4 | 0.49371989 |
77 | IRAK1 | 0.48592747 |
78 | FES | 0.48184402 |
79 | PRKG2 | 0.47096641 |
80 | MAP2K2 | 0.46968024 |
81 | MAP2K6 | 0.46559446 |
82 | SGK223 | 0.46412975 |
83 | SGK494 | 0.46412975 |
84 | TAOK2 | 0.45973343 |
85 | LRRK2 | 0.45032525 |
86 | PRKD2 | 0.42030293 |
87 | CDK9 | 0.42020683 |
88 | MAP2K4 | 0.41340210 |
89 | LCK | 0.41247532 |
90 | HCK | 0.41149966 |
91 | MAPK12 | 0.39544092 |
92 | MAPKAPK3 | 0.38965999 |
93 | DYRK1B | 0.38826611 |
94 | PRKCZ | 0.38806131 |
95 | SIK2 | 0.38741647 |
96 | TRPM7 | 0.38512603 |
97 | MAP3K11 | 0.38354148 |
98 | BCKDK | 0.37865770 |
99 | MAPK3 | 0.37746516 |
100 | SYK | 0.37417607 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Caffeine metabolism_Homo sapiens_hsa00232 | 4.56056308 |
2 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 4.03025149 |
3 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 3.82532754 |
4 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.67418403 |
5 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.42360545 |
6 | Retinol metabolism_Homo sapiens_hsa00830 | 3.30255652 |
7 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 3.25384937 |
8 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 2.79762436 |
9 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.79109488 |
10 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.70418420 |
11 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 2.66788389 |
12 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.66057318 |
13 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.65502372 |
14 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 2.52962432 |
15 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.48387993 |
16 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.48059193 |
17 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.16718716 |
18 | Tyrosine metabolism_Homo sapiens_hsa00350 | 2.16378172 |
19 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.06132469 |
20 | Histidine metabolism_Homo sapiens_hsa00340 | 1.92744975 |
21 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.83585693 |
22 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.81557066 |
23 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.77061150 |
24 | Bile secretion_Homo sapiens_hsa04976 | 1.74504108 |
25 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.62605746 |
26 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.58163122 |
27 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.53653239 |
28 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.47806256 |
29 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.40226554 |
30 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.31385615 |
31 | Peroxisome_Homo sapiens_hsa04146 | 1.21682068 |
32 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.20730915 |
33 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.14013309 |
34 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.12656358 |
35 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.11727223 |
36 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.04511589 |
37 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.04321483 |
38 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.00014995 |
39 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.97793227 |
40 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.95761582 |
41 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.94952811 |
42 | Prion diseases_Homo sapiens_hsa05020 | 0.93995242 |
43 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.91844402 |
44 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.89466822 |
45 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.88415607 |
46 | Carbon metabolism_Homo sapiens_hsa01200 | 0.88293028 |
47 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.81387062 |
48 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.81114337 |
49 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.80680825 |
50 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.80270362 |
51 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.74348607 |
52 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.71116665 |
53 | Lysine degradation_Homo sapiens_hsa00310 | 0.68904160 |
54 | ABC transporters_Homo sapiens_hsa02010 | 0.68450456 |
55 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.66203117 |
56 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.66102753 |
57 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.52231509 |
58 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.50233149 |
59 | Other glycan degradation_Homo sapiens_hsa00511 | 0.48754548 |
60 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.45260247 |
61 | Pertussis_Homo sapiens_hsa05133 | 0.42265460 |
62 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.41969976 |
63 | Sulfur relay system_Homo sapiens_hsa04122 | 0.39523003 |
64 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.35987320 |
65 | Metabolic pathways_Homo sapiens_hsa01100 | 0.35324083 |
66 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.35263348 |
67 | Insulin resistance_Homo sapiens_hsa04931 | 0.33352993 |
68 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.30257075 |
69 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.25944843 |
70 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.20691087 |
71 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.20403303 |
72 | Galactose metabolism_Homo sapiens_hsa00052 | 0.17159255 |
73 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.14909210 |
74 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.11561494 |
75 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.09392058 |
76 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.09169315 |
77 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.06838036 |
78 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.04698549 |
79 | Mineral absorption_Homo sapiens_hsa04978 | 0.04336157 |
80 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.03613206 |
81 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.02565620 |
82 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | -0.1890669 |
83 | Ether lipid metabolism_Homo sapiens_hsa00565 | -0.1842944 |
84 | Serotonergic synapse_Homo sapiens_hsa04726 | -0.1821848 |
85 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.1780089 |
86 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | -0.1758752 |
87 | Leishmaniasis_Homo sapiens_hsa05140 | -0.1747735 |
88 | Type II diabetes mellitus_Homo sapiens_hsa04930 | -0.1738364 |
89 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | -0.1614482 |
90 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | -0.1566244 |
91 | Acute myeloid leukemia_Homo sapiens_hsa05221 | -0.1491600 |
92 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | -0.1438782 |
93 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | -0.1299034 |
94 | Hepatitis C_Homo sapiens_hsa05160 | -0.1117522 |
95 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.0918642 |
96 | Sphingolipid metabolism_Homo sapiens_hsa00600 | -0.0902516 |
97 | Selenocompound metabolism_Homo sapiens_hsa00450 | -0.0618076 |
98 | AMPK signaling pathway_Homo sapiens_hsa04152 | -0.0425837 |
99 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | -0.0296552 |
100 | Amoebiasis_Homo sapiens_hsa05146 | -0.0042311 |