RBP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the cellular retinol-binding protein (CRBP) family, whose members are required for vitamin A stability and metabolism. The encoded protein binds all-trans-retinol and is structurally similar to other CRBPs; however, it has a lower binding affinity for retinol than other CRBPs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)8.23254575
2low-density lipoprotein particle clearance (GO:0034383)7.20639093
3transcytosis (GO:0045056)7.00186949
4phagocytosis, recognition (GO:0006910)6.28785271
5fatty acid transmembrane transport (GO:1902001)5.73374956
6brown fat cell differentiation (GO:0050873)5.57095552
7regulation of cholesterol storage (GO:0010885)5.56782295
8white fat cell differentiation (GO:0050872)5.50884982
9retina vasculature morphogenesis in camera-type eye (GO:0061299)5.00040595
10triglyceride catabolic process (GO:0019433)4.69508258
11negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.63215990
12neutrophil activation involved in immune response (GO:0002283)4.51243031
13carnitine shuttle (GO:0006853)4.44998071
14lymph vessel development (GO:0001945)4.39604051
15negative regulation of cell killing (GO:0031342)4.33470589
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.33470589
17positive regulation of lipid storage (GO:0010884)4.31963694
18bundle of His cell to Purkinje myocyte communication (GO:0086069)4.28599477
19positive regulation by symbiont of host defense response (GO:0052509)4.21765733
20modulation by symbiont of host defense response (GO:0052031)4.21765733
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.21765733
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.21765733
23positive regulation by organism of defense response of other organism involved in symbiotic interact4.21765733
24modulation by symbiont of host immune response (GO:0052553)4.21765733
25lipid storage (GO:0019915)4.18366982
26fatty acid beta-oxidation (GO:0006635)4.18301690
27leukocyte migration involved in inflammatory response (GO:0002523)4.11538794
28negative regulation of lipid storage (GO:0010888)4.10110266
29biotin metabolic process (GO:0006768)4.07214688
30negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.06244159
31ovulation from ovarian follicle (GO:0001542)4.01913921
32tricarboxylic acid cycle (GO:0006099)4.00725495
33neutral lipid catabolic process (GO:0046461)3.99711413
34acylglycerol catabolic process (GO:0046464)3.99711413
35NADH metabolic process (GO:0006734)3.99550620
36regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.97923731
37lipid particle organization (GO:0034389)3.96921671
38branched-chain amino acid catabolic process (GO:0009083)3.91615743
39vascular endothelial growth factor signaling pathway (GO:0038084)3.91308438
40regulation of actin filament-based movement (GO:1903115)3.90537383
41negative regulation of phagocytosis (GO:0050765)3.84217326
42detection of molecule of bacterial origin (GO:0032490)3.83145394
43negative regulation of protein autophosphorylation (GO:0031953)3.81838913
44negative regulation of interleukin-12 production (GO:0032695)3.76942253
45response to dietary excess (GO:0002021)3.74827250
46positive regulation of fatty acid oxidation (GO:0046321)3.73702871
47regulation of lipid storage (GO:0010883)3.72882798
48valine metabolic process (GO:0006573)3.71211684
49sarcomere organization (GO:0045214)3.70700311
50detection of other organism (GO:0098543)3.66855162
51negative regulation of amino acid transport (GO:0051956)3.65552786
52branched-chain amino acid metabolic process (GO:0009081)3.63891252
53response to peptidoglycan (GO:0032494)3.62357190
54macrophage activation involved in immune response (GO:0002281)3.62151398
55regulation of glycogen (starch) synthase activity (GO:2000465)3.62146256
56neutrophil activation (GO:0042119)3.59295637
57positive regulation of macrophage cytokine production (GO:0060907)3.57492664
58regulation of acyl-CoA biosynthetic process (GO:0050812)3.56802701
59negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.56091322
60regulation of macrophage derived foam cell differentiation (GO:0010743)3.54662321
61negative regulation of response to food (GO:0032096)3.53405338
62negative regulation of appetite (GO:0032099)3.53405338
63fatty acid oxidation (GO:0019395)3.51585079
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.50675210
65tyrosine phosphorylation of STAT protein (GO:0007260)3.49961572
66positive regulation of mast cell activation (GO:0033005)3.47416672
67cellular response to leptin stimulus (GO:0044320)3.46242592
68regulation of relaxation of muscle (GO:1901077)3.43441137
69lipid oxidation (GO:0034440)3.43001594
70polyol transport (GO:0015791)3.42733314
71cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.42580930
72detection of external biotic stimulus (GO:0098581)3.42322818
73cardiac myofibril assembly (GO:0055003)3.41440174
74cGMP-mediated signaling (GO:0019934)3.40922812
75positive regulation of gamma-delta T cell activation (GO:0046645)3.40751279
76detection of bacterium (GO:0016045)3.40214694
77diacylglycerol metabolic process (GO:0046339)3.39235082
78regulation of cardiac muscle cell contraction (GO:0086004)3.38649000
79regulation of fatty acid oxidation (GO:0046320)3.38233989
80ventricular cardiac muscle cell action potential (GO:0086005)3.37609427
81negative regulation of granulocyte differentiation (GO:0030853)3.34610506
82fatty acid catabolic process (GO:0009062)3.33955576
83heart trabecula formation (GO:0060347)3.33716279
84cellular response to epinephrine stimulus (GO:0071872)3.32381468
85myofibril assembly (GO:0030239)3.30980359
86regulation of sarcomere organization (GO:0060297)3.30748138
87endothelial cell morphogenesis (GO:0001886)3.25773735
88granulocyte activation (GO:0036230)3.24653704
89carnitine transmembrane transport (GO:1902603)3.22440239
90detection of biotic stimulus (GO:0009595)3.21798477
91negative regulation of systemic arterial blood pressure (GO:0003085)3.21204659
92regulation of gonadotropin secretion (GO:0032276)3.21175031
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20584060
94adhesion of symbiont to host (GO:0044406)3.18557375
95microglial cell activation (GO:0001774)3.11363800
96cellular extravasation (GO:0045123)3.10737235
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09757337
98hemidesmosome assembly (GO:0031581)3.08624230
99gas transport (GO:0015669)3.08152827
100ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.05869588
101cellular response to lithium ion (GO:0071285)3.05698743
102negative regulation of tumor necrosis factor production (GO:0032720)3.04161140
103angiogenesis involved in wound healing (GO:0060055)3.03849012
104endocrine hormone secretion (GO:0060986)3.02187915
105positive regulation of interleukin-1 secretion (GO:0050716)3.00824099
106positive regulation of toll-like receptor signaling pathway (GO:0034123)3.00769980
107regulation of p38MAPK cascade (GO:1900744)3.00231496
108regulation of coenzyme metabolic process (GO:0051196)2.99714452
109regulation of cofactor metabolic process (GO:0051193)2.99714452
110cellular response to nitric oxide (GO:0071732)2.98476354
111glomerular filtration (GO:0003094)2.98281596
112interferon-gamma production (GO:0032609)2.98211380
113negative regulation of nitric-oxide synthase activity (GO:0051001)2.97786987
114long-chain fatty acid transport (GO:0015909)2.97594025
115CDP-diacylglycerol metabolic process (GO:0046341)2.96981829
116negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.96239483
117glycerolipid catabolic process (GO:0046503)2.96081066
118negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.95720898
119regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.94016510
120negative regulation of macrophage differentiation (GO:0045650)2.93026836
121positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.91567230
122response to epinephrine (GO:0071871)2.91295593
123respiratory burst (GO:0045730)2.89819955
124positive regulation of p38MAPK cascade (GO:1900745)2.89343484
125leukocyte tethering or rolling (GO:0050901)2.88961371
126positive regulation of protein homooligomerization (GO:0032464)2.88642858
127glycerol metabolic process (GO:0006071)2.88516034
128positive regulation of mast cell activation involved in immune response (GO:0033008)2.88176001
129positive regulation of mast cell degranulation (GO:0043306)2.88176001
130regulation of protein kinase A signaling (GO:0010738)2.87845041
131negative regulation of potassium ion transmembrane transport (GO:1901380)2.87492487
132macrophage activation (GO:0042116)2.85497970
133regulation of cell communication by electrical coupling (GO:0010649)2.85206433
134regulation of triglyceride biosynthetic process (GO:0010866)2.84662520
135regulation of mast cell degranulation (GO:0043304)2.84316418
136regulation of interferon-beta biosynthetic process (GO:0045357)2.83331989
137response to leptin (GO:0044321)2.82946640
138actin-myosin filament sliding (GO:0033275)2.82738430
139muscle filament sliding (GO:0030049)2.82738430
140cardiac muscle tissue morphogenesis (GO:0055008)2.82654453
141negative regulation of interleukin-1 production (GO:0032692)2.81413819
142positive regulation of glomerulus development (GO:0090193)2.81329208
143positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.81160564
144negative regulation of innate immune response (GO:0045824)2.80453007
145regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.80094527
146cardiac muscle cell development (GO:0055013)2.80093763
147positive regulation of lipoprotein lipase activity (GO:0051006)2.79333786
148positive regulation of triglyceride lipase activity (GO:0061365)2.79333786
149fatty acid homeostasis (GO:0055089)2.79299134
150antigen processing and presentation of endogenous antigen (GO:0019883)2.79265723
151amino-acid betaine transport (GO:0015838)2.78928841
152carnitine transport (GO:0015879)2.78928841
153positive regulation of oligodendrocyte differentiation (GO:0048714)2.77683320
154positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.76575841
155neutrophil mediated immunity (GO:0002446)2.75490549
156respiratory electron transport chain (GO:0022904)2.75167728
157response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.74988601
158response to host immune response (GO:0052572)2.74988601
159cellular response to reactive nitrogen species (GO:1902170)2.72733153
160regulation of mast cell activation (GO:0033003)2.72511601
161desmosome organization (GO:0002934)2.72034034
162negative regulation of DNA biosynthetic process (GO:2000279)2.71911251
163regulation of skeletal muscle contraction (GO:0014819)2.71815583
164regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.71801236
165cardiac muscle contraction (GO:0060048)2.70528901
166negative regulation of lymphocyte mediated immunity (GO:0002707)2.67362613
167myeloid cell activation involved in immune response (GO:0002275)2.67148560
168cardiac cell development (GO:0055006)2.66232647
169electron transport chain (GO:0022900)2.66159676
170regulation of mast cell activation involved in immune response (GO:0033006)2.64401287
171adrenergic receptor signaling pathway (GO:0071875)2.64160719
172negative regulation of cAMP-mediated signaling (GO:0043951)2.62006555
173response to vitamin E (GO:0033197)2.60869623
174hydrogen peroxide biosynthetic process (GO:0050665)2.59805105
175leukocyte aggregation (GO:0070486)2.58843138
176plasma lipoprotein particle clearance (GO:0034381)2.58619799
177antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58295781
178CDP-diacylglycerol biosynthetic process (GO:0016024)2.56123288
179positive regulation of interleukin-8 production (GO:0032757)2.55355281

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.06373474
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.56761920
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.49871232
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.35930318
5GATA1_22025678_ChIP-Seq_K562_Human3.23771751
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.18991830
7CLOCK_20551151_ChIP-Seq_293T_Human3.15893283
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.89258058
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.72044878
10GATA2_21666600_ChIP-Seq_HMVEC_Human2.57240890
11STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.54333142
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.50420791
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49883091
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37860390
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35365587
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.25335488
17ZNF263_19887448_ChIP-Seq_K562_Human2.12270348
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.11341189
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07691270
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06653240
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse10.8119627
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96618081
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94391018
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93645635
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.92891206
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.83206267
27PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.81781365
28EZH2_22144423_ChIP-Seq_EOC_Human1.81271293
29SPI1_23547873_ChIP-Seq_NB4_Human1.78135761
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77084012
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76629338
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.76499441
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76157396
34BCL6_27268052_Chip-Seq_Bcells_Human1.70870081
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67861606
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66314536
37STAT1_20625510_ChIP-Seq_HELA_Human1.65847969
38GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.65422307
39* TBX20_22080862_ChIP-Seq_HEART_Mouse1.64610061
40* TBX20_22328084_ChIP-Seq_HEART_Mouse1.64610061
41* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59477217
42CJUN_26792858_Chip-Seq_BT549_Human1.59428472
43SPI1_23127762_ChIP-Seq_K562_Human1.58388294
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55374402
45* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50406670
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.50404495
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48084153
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47980763
49* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.47464892
50PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46845337
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45261315
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45060662
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44372089
54ERA_21632823_ChIP-Seq_H3396_Human1.44230169
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.43457387
56BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.42358094
57RUNX_20019798_ChIP-Seq_JUKART_Human1.42301807
58VDR_21846776_ChIP-Seq_THP-1_Human1.41450432
59VDR_24763502_ChIP-Seq_THP-1_Human1.40271390
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.39338268
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38666672
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38596343
63P68_20966046_ChIP-Seq_HELA_Human1.34928196
64FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34190854
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33641948
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32506072
67* SA1_27219007_Chip-Seq_Bcells_Human1.32035043
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30452841
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28895390
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28605026
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28503507
72RXR_22158963_ChIP-Seq_LIVER_Mouse1.28193631
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28161178
74BCOR_27268052_Chip-Seq_Bcells_Human1.27773959
75SOX2_20726797_ChIP-Seq_SW620_Human1.27599574
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27142063
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26636365
78* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25798930
79E2F1_20622854_ChIP-Seq_HELA_Human1.24832601
80* YY1_22570637_ChIP-Seq_MALME-3M_Human1.24648378
81* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24383999
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.23031344
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20313881
84SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19997899
85STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19800449
86* NANOG_20526341_ChIP-Seq_ESCs_Human1.19341414
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19139342
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18971781
89FOXH1_21741376_ChIP-Seq_ESCs_Human1.18914161
90AHR_22903824_ChIP-Seq_MCF-7_Human1.18742895
91RAC3_21632823_ChIP-Seq_H3396_Human1.18509565
92CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18169278
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17428341
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15902546
95GATA3_26560356_Chip-Seq_TH2_Human1.15880074
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15592294
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15284165
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14849364
99BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14084476
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12012685
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11307276
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10993082
103* TET1_21451524_ChIP-Seq_MESCs_Mouse1.10330076
104SPI1_20517297_ChIP-Seq_HL60_Human1.10015768
105EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09782264
106RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09782264
107CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08534170
108MAF_26560356_Chip-Seq_TH2_Human1.07402364
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07343461
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07231854
111VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07197752
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06900235
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06440936
114PHF8_20622854_ChIP-Seq_HELA_Human1.05955136
115KLF4_19829295_ChIP-Seq_ESCs_Human1.05824469
116OCT4_19829295_ChIP-Seq_ESCs_Human1.05761651
117P300_27268052_Chip-Seq_Bcells_Human1.05619502
118* CTCF_26484167_Chip-Seq_Bcells_Mouse1.04938280
119PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04296956
120PIAS1_25552417_ChIP-Seq_VCAP_Human1.03994721
121ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03220632
122* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02947947
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02866538
124CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01046629
125BCAT_22108803_ChIP-Seq_LS180_Human1.00720702
126BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.99731997
127* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98879606
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98345023
129* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98276757
130SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97997359
131LXR_22292898_ChIP-Seq_THP-1_Human0.97024814
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96745958
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96745958
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96745958
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96281606
136* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.95825651
137SALL1_21062744_ChIP-ChIP_HESCs_Human0.94749720
138STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93983505
139GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93416479
140* CTCF_20526341_ChIP-Seq_ESCs_Human0.93390331
141SA1_27219007_Chip-Seq_ERYTHROID_Human0.92997308
142AR_21572438_ChIP-Seq_LNCaP_Human0.92194895
143GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91920882
144CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91672048
145RXR_22108803_ChIP-Seq_LS180_Human0.90739096
146FLI1_27457419_Chip-Seq_LIVER_Mouse0.90625482
147SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90562255
148OCT4_20526341_ChIP-Seq_ESCs_Human0.89854281
149LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89845718
150EZH2_27304074_Chip-Seq_ESCs_Mouse0.89621189
151GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89297212
152SOX2_21211035_ChIP-Seq_LN229_Human0.89080011
153ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89002295
154ER_23166858_ChIP-Seq_MCF-7_Human0.86727804
155ELF1_20517297_ChIP-Seq_JURKAT_Human0.86628248
156HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86386857
157RUNX1_27514584_Chip-Seq_MCF-7_Human0.86296199
158NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85965294
159LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85958203
160ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85685300
161EED_16625203_ChIP-ChIP_MESCs_Mouse0.84658540
162NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84302775
163PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82098762
164UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81728634
165ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81408172
166P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81123728
167PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80949478
168PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80689340
169WT1_19549856_ChIP-ChIP_CCG9911_Human0.80321842
170NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79723577
171JARID2_20075857_ChIP-Seq_MESCs_Mouse0.79205061
172* GATA3_21878914_ChIP-Seq_MCF-7_Human0.79199779
173SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.76104960
174FOXO3_23340844_ChIP-Seq_DLD1_Human0.75100681
175POU3F2_20337985_ChIP-ChIP_501MEL_Human0.74426690
176LXR_22158963_ChIP-Seq_LIVER_Mouse0.72938653
177GBX2_23144817_ChIP-Seq_PC3_Human0.72745197
178GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72736716
179TP53_18474530_ChIP-ChIP_U2OS_Human0.70835220
180VDR_24787735_ChIP-Seq_THP-1_Human0.70490090
181NR3C1_21868756_ChIP-Seq_MCF10A_Human0.70286691
182CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.69300443
183EZH2_27294783_Chip-Seq_ESCs_Mouse0.68816443
184SMC3_22415368_ChIP-Seq_MEFs_Mouse0.68778685
185* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67507051
186SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.66598278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose7.69215100
2MP0005666_abnormal_adipose_tissue4.37318848
3MP0002837_dystrophic_cardiac_calcinosis4.21991839
4MP0004130_abnormal_muscle_cell3.92477378
5MP0004185_abnormal_adipocyte_glucose3.75001054
6MP0003724_increased_susceptibility_to3.54922807
7MP0004084_abnormal_cardiac_muscle3.33769105
8MP0005375_adipose_tissue_phenotype3.28490933
9MP0003011_delayed_dark_adaptation3.19340796
10MP0004215_abnormal_myocardial_fiber3.05859686
11MP0000013_abnormal_adipose_tissue2.92645111
12MP0003828_pulmonary_edema2.81794462
13MP0001881_abnormal_mammary_gland2.68036037
14MP0003646_muscle_fatigue2.55871963
15MP0001879_abnormal_lymphatic_vessel2.55794565
16MP0004147_increased_porphyrin_level2.52471407
17MP0000003_abnormal_adipose_tissue2.51864236
18MP0003303_peritoneal_inflammation2.34362201
19MP0005330_cardiomyopathy2.29183250
20MP0004036_abnormal_muscle_relaxation2.28638443
21MP0000750_abnormal_muscle_regeneration2.27116257
22MP0000343_altered_response_to2.26672272
23MP0003950_abnormal_plasma_membrane2.02162464
24MP0000751_myopathy2.01909740
25MP0002419_abnormal_innate_immunity1.97006200
26MP0002972_abnormal_cardiac_muscle1.94715569
27MP0003436_decreased_susceptibility_to1.94017590
28MP0002876_abnormal_thyroid_physiology1.93561656
29MP0009785_altered_susceptibility_to1.91991256
30MP0002254_reproductive_system_inflammat1.86563106
31MP0004484_altered_response_of1.84916085
32MP0001986_abnormal_taste_sensitivity1.83146535
33MP0005620_abnormal_muscle_contractility1.82733373
34MP0009379_abnormal_foot_pigmentation1.80639519
35MP0004272_abnormal_basement_membrane1.79810953
36MP0005385_cardiovascular_system_phenoty1.75605643
37MP0001544_abnormal_cardiovascular_syste1.75605643
38MP0009115_abnormal_fat_cell1.75225536
39MP0006082_CNS_inflammation1.71272475
40MP0005025_abnormal_response_to1.69762243
41MP0002971_abnormal_brown_adipose1.69598058
42MP0010368_abnormal_lymphatic_system1.67295447
43MP0000749_muscle_degeneration1.65866440
44MP0008438_abnormal_cutaneous_collagen1.65464012
45MP0001835_abnormal_antigen_presentation1.64887010
46MP0008775_abnormal_heart_ventricle1.61645095
47MP0004087_abnormal_muscle_fiber1.59857465
48MP0006138_congestive_heart_failure1.58873222
49MP0008260_abnormal_autophagy1.58246289
50MP0002148_abnormal_hypersensitivity_rea1.55944273
51MP0005671_abnormal_response_to1.54678267
52MP0001533_abnormal_skeleton_physiology1.53665725
53MP0005171_absent_coat_pigmentation1.52802408
54MP0003941_abnormal_skin_development1.50625527
55MP0005084_abnormal_gallbladder_morpholo1.47412041
56MP0003075_altered_response_to1.45766761
57MP0005334_abnormal_fat_pad1.41154839
58MP0003137_abnormal_impulse_conducting1.39526818
59MP0005000_abnormal_immune_tolerance1.39275673
60MP0002723_abnormal_immune_serum1.34547852
61MP0003787_abnormal_imprinting1.34240287
62MP0001800_abnormal_humoral_immune1.32573233
63MP0009764_decreased_sensitivity_to1.30728695
64MP0001790_abnormal_immune_system1.30617434
65MP0005387_immune_system_phenotype1.30617434
66MP0010630_abnormal_cardiac_muscle1.30085273
67MP0002420_abnormal_adaptive_immunity1.29859688
68MP0001819_abnormal_immune_cell1.28149341
69MP0000685_abnormal_immune_system1.24034444
70MP0002452_abnormal_antigen_presenting1.23935598
71MP0002132_abnormal_respiratory_system1.16918452
72MP0003566_abnormal_cell_adhesion1.15499745
73MP0001188_hyperpigmentation1.14054996
74MP0006276_abnormal_autonomic_nervous1.13878647
75MP0002909_abnormal_adrenal_gland1.13502856
76MP0010329_abnormal_lipoprotein_level1.12954057
77MP0002106_abnormal_muscle_physiology1.12816755
78MP0002970_abnormal_white_adipose1.10513468
79MP0000759_abnormal_skeletal_muscle1.08428005
80MP0005083_abnormal_biliary_tract1.08391460
81MP0005275_abnormal_skin_tensile1.08018045
82MP0005165_increased_susceptibility_to1.05820808
83MP0004085_abnormal_heartbeat1.03387862
84MP0003221_abnormal_cardiomyocyte_apopto1.02081890
85MP0003806_abnormal_nucleotide_metabolis1.02062566
86MP0005167_abnormal_blood-brain_barrier0.98383707
87MP0002332_abnormal_exercise_endurance0.98163430
88MP0002118_abnormal_lipid_homeostasis0.97320040
89MP0005464_abnormal_platelet_physiology0.96807329
90MP0001845_abnormal_inflammatory_respons0.96605710
91MP0005369_muscle_phenotype0.96369748
92MP0001764_abnormal_homeostasis0.95201909
93MP0002405_respiratory_system_inflammati0.92476450
94MP0002277_abnormal_respiratory_mucosa0.92237926
95MP0005058_abnormal_lysosome_morphology0.92021062
96MP0006036_abnormal_mitochondrial_physio0.91471458
97MP0005647_abnormal_sex_gland0.91145404
98MP0004883_abnormal_blood_vessel0.88995424
99MP0008469_abnormal_protein_level0.87569024
100MP0005365_abnormal_bile_salt0.86153188
101MP0000230_abnormal_systemic_arterial0.85976676
102MP0001851_eye_inflammation0.85821866
103MP0002933_joint_inflammation0.82833095
104MP0002822_catalepsy0.82617211
105MP0002108_abnormal_muscle_morphology0.79999802
106MP0005266_abnormal_metabolism0.79146983
107MP0009333_abnormal_splenocyte_physiolog0.77512797
108MP0005535_abnormal_body_temperature0.77207044
109MP0000566_synostosis0.75718252
110MP0000609_abnormal_liver_physiology0.75187172
111MP0005164_abnormal_response_to0.74891770
112MP0005595_abnormal_vascular_smooth0.74719023
113MP0002127_abnormal_cardiovascular_syste0.73828176
114MP0003045_fibrosis0.73750896
115MP0000716_abnormal_immune_system0.72613790
116MP0000249_abnormal_blood_vessel0.71813245
117MP0003959_abnormal_lean_body0.71588401
118MP0001663_abnormal_digestive_system0.71207003
119MP0001661_extended_life_span0.69788670
120MP0005379_endocrine/exocrine_gland_phen0.68971291
121MP0005397_hematopoietic_system_phenotyp0.68332138
122MP0001545_abnormal_hematopoietic_system0.68332138
123MP0003186_abnormal_redox_activity0.68088414
124MP0002078_abnormal_glucose_homeostasis0.68046703
125MP0005584_abnormal_enzyme/coenzyme_acti0.67656821
126MP0002295_abnormal_pulmonary_circulatio0.67197704
127MP0003879_abnormal_hair_cell0.66342969
128MP0001501_abnormal_sleep_pattern0.66110088
129MP0002638_abnormal_pupillary_reflex0.64780864
130MP0000689_abnormal_spleen_morphology0.64641662
131MP0000767_abnormal_smooth_muscle0.64134650
132MP0005319_abnormal_enzyme/_coenzyme0.63757404
133MP0003191_abnormal_cellular_cholesterol0.62008276
134MP0002653_abnormal_ependyma_morphology0.61212799
135MP0005452_abnormal_adipose_tissue0.60722567
136MP0008874_decreased_physiological_sensi0.60650404
137MP0005388_respiratory_system_phenotype0.59040283
138MP0002133_abnormal_respiratory_system0.59040283
139MP0005376_homeostasis/metabolism_phenot0.58728788
140MP0003948_abnormal_gas_homeostasis0.58379876
141MP0000858_altered_metastatic_potential0.57572929
142MP0003690_abnormal_glial_cell0.55397188
143MP0008995_early_reproductive_senescence0.54792983
144MP0005377_hearing/vestibular/ear_phenot0.54500112
145MP0003878_abnormal_ear_physiology0.54500112
146MP0000627_abnormal_mammary_gland0.53934463
147MP0002060_abnormal_skin_morphology0.53346271
148MP0002269_muscular_atrophy0.53264509
149MP0004510_myositis0.52980158
150MP0009278_abnormal_bone_marrow0.50957130
151MP0005448_abnormal_energy_balance0.50450075
152MP0000266_abnormal_heart_morphology0.50394885
153MP0002877_abnormal_melanocyte_morpholog0.50030073
154MP0003279_aneurysm0.48006896
155MP0001727_abnormal_embryo_implantation0.45864782
156MP0003448_altered_tumor_morphology0.45102903
157MP0004381_abnormal_hair_follicle0.44406836

Predicted human phenotypes

RankGene SetZ-score
1Ventricular tachycardia (HP:0004756)5.44319355
2Oligomenorrhea (HP:0000876)5.32185262
3Stomatitis (HP:0010280)5.21959665
4Muscle fiber splitting (HP:0003555)5.09761147
5Right ventricular cardiomyopathy (HP:0011663)4.83079562
6Insulin-resistant diabetes mellitus (HP:0000831)4.65346703
7Sudden death (HP:0001699)4.60140087
8Recurrent bacterial skin infections (HP:0005406)4.56846092
9Atrial fibrillation (HP:0005110)4.56277535
10Lipoatrophy (HP:0100578)4.51442932
11Myositis (HP:0100614)4.51062392
12Recurrent abscess formation (HP:0002722)4.44447383
13Orchitis (HP:0100796)4.31336367
14Primary atrial arrhythmia (HP:0001692)4.24568346
15Increased connective tissue (HP:0009025)4.23813011
16Optic neuritis (HP:0100653)4.21317303
17Retrobulbar optic neuritis (HP:0100654)4.21317303
18Acanthosis nigricans (HP:0000956)4.12440660
19Supraventricular arrhythmia (HP:0005115)4.09883477
20Supraventricular tachycardia (HP:0004755)4.07794271
21Elevated erythrocyte sedimentation rate (HP:0003565)4.07001264
22Difficulty running (HP:0009046)4.05425072
23Reduced subcutaneous adipose tissue (HP:0003758)4.03411768
24Stomach cancer (HP:0012126)3.94275000
25Prolonged QT interval (HP:0001657)3.84596992
26Myoglobinuria (HP:0002913)3.82977717
27Eczematoid dermatitis (HP:0000976)3.81934510
28Abnormality of macrophages (HP:0004311)3.80010705
29Rhabdomyolysis (HP:0003201)3.74127115
30Palpitations (HP:0001962)3.72433279
31Exercise-induced myalgia (HP:0003738)3.58723033
32Dilated cardiomyopathy (HP:0001644)3.57383801
33Hypertriglyceridemia (HP:0002155)3.51726190
34Amyloidosis (HP:0011034)3.48410442
35Hyporeflexia of lower limbs (HP:0002600)3.48334234
36Distal lower limb muscle weakness (HP:0009053)3.47160776
37Toxemia of pregnancy (HP:0100603)3.41247849
38Abnormality of fatty-acid metabolism (HP:0004359)3.40726551
39Recurrent gram-negative bacterial infections (HP:0005420)3.40331112
40Syncope (HP:0001279)3.36390066
41Bundle branch block (HP:0011710)3.24603504
42Hyperglycinuria (HP:0003108)3.24562840
43Keratoconjunctivitis (HP:0001096)3.21037859
44Increased muscle lipid content (HP:0009058)3.16208693
45Keratoconjunctivitis sicca (HP:0001097)3.15682489
46Obstructive lung disease (HP:0006536)3.08845430
47Chronic obstructive pulmonary disease (HP:0006510)3.08845430
48Prolonged bleeding time (HP:0003010)3.08359779
49Dicarboxylic aciduria (HP:0003215)3.03364083
50Abnormality of dicarboxylic acid metabolism (HP:0010995)3.03364083
51Calf muscle hypertrophy (HP:0008981)3.03231912
52Hepatic necrosis (HP:0002605)3.00582291
53Polyphagia (HP:0002591)2.99330035
54Gastrointestinal infarctions (HP:0005244)2.96182816
55Hyperalaninemia (HP:0003348)2.95568103
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.95568103
57Abnormality of alanine metabolism (HP:0010916)2.95568103
58Hypoglycemic coma (HP:0001325)2.94603427
59Metaphyseal dysplasia (HP:0100255)2.94122041
60Abnormal eating behavior (HP:0100738)2.91079330
61Hypochromic microcytic anemia (HP:0004840)2.90332679
62Hypercortisolism (HP:0001578)2.89553958
63Recurrent skin infections (HP:0001581)2.87386428
64Decreased subcutaneous fat (HP:0001002)2.86986318
65Heart block (HP:0012722)2.85728912
66Abnormal atrioventricular conduction (HP:0005150)2.85374225
67Insulin resistance (HP:0000855)2.81372108
68Abnormality of the calf musculature (HP:0001430)2.80622815
69Myotonia (HP:0002486)2.78847034
70Hyperglycemia (HP:0003074)2.74851631
71Hypoalphalipoproteinemia (HP:0003233)2.74123751
72Abnormal mitochondria in muscle tissue (HP:0008316)2.73807456
73Hyperlipoproteinemia (HP:0010980)2.72445510
74Increased IgM level (HP:0003496)2.69231577
75Ileus (HP:0002595)2.66598242
76Abnormal EKG (HP:0003115)2.66575277
77Muscle hypertrophy of the lower extremities (HP:0008968)2.66345904
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.63553241
79Episodic fever (HP:0001954)2.60788806
80EMG: myopathic abnormalities (HP:0003458)2.60678683
81Subaortic stenosis (HP:0001682)2.59187198
82Abnormality of the left ventricular outflow tract (HP:0011103)2.59187198
83Mediastinal lymphadenopathy (HP:0100721)2.57454943
84Testicular atrophy (HP:0000029)2.56678830
85Encephalitis (HP:0002383)2.55525486
86Urticaria (HP:0001025)2.54760908
87Ketoacidosis (HP:0001993)2.54588433
88Acute necrotizing encephalopathy (HP:0006965)2.54119055
89Facial diplegia (HP:0001349)2.53588398
90Hemoptysis (HP:0002105)2.53580338
91Bradycardia (HP:0001662)2.52426918
92Neck muscle weakness (HP:0000467)2.52408535
93Absent rod-and cone-mediated responses on ERG (HP:0007688)2.52025878
94Spontaneous hematomas (HP:0007420)2.51958153
95Bone cyst (HP:0012062)2.50112506
96Maternal diabetes (HP:0009800)2.49964767
97Muscle stiffness (HP:0003552)2.48035942
98Ventricular arrhythmia (HP:0004308)2.46525973
99Atrioventricular block (HP:0001678)2.46200595
100Pigmentary retinal degeneration (HP:0001146)2.42020209
101Ventricular fibrillation (HP:0001663)2.41700766
102Prenatal maternal abnormality (HP:0002686)2.41238363
103Colitis (HP:0002583)2.41163571
104Abnormality of liposaccharide metabolism (HP:0010968)2.40972267
105Abnormality of glycosphingolipid metabolism (HP:0004343)2.40972267
106Abnormality of glycolipid metabolism (HP:0010969)2.40972267
107Gingivitis (HP:0000230)2.36218695
108Exercise intolerance (HP:0003546)2.36140115
109Vasculitis (HP:0002633)2.35539622
110Purpura (HP:0000979)2.33443674
111Areflexia of lower limbs (HP:0002522)2.32794384
112Inflammation of the large intestine (HP:0002037)2.32375813
113Meningitis (HP:0001287)2.31469582
114Systemic lupus erythematosus (HP:0002725)2.29526603
115Nausea (HP:0002018)2.28757799
116Congenital, generalized hypertrichosis (HP:0004540)2.28625841
117Abnormality of serine family amino acid metabolism (HP:0010894)2.27377720
118Abnormality of glycine metabolism (HP:0010895)2.27377720
119Exercise-induced muscle cramps (HP:0003710)2.25436098
120Acute encephalopathy (HP:0006846)2.25275468
121Increased variability in muscle fiber diameter (HP:0003557)2.23920583
122Broad metatarsal (HP:0001783)2.23877798
123Spinal rigidity (HP:0003306)2.23216168
124Hypochromic anemia (HP:0001931)2.23097803
125Abnormal hemoglobin (HP:0011902)2.21400564
126Recurrent fungal infections (HP:0002841)2.20127075
127Hepatocellular necrosis (HP:0001404)2.19513473
128Mutism (HP:0002300)2.18419462
129Generalized aminoaciduria (HP:0002909)2.17306964
130Difficulty climbing stairs (HP:0003551)2.15734496
131Long foot (HP:0001833)2.15601172
132Gastrointestinal inflammation (HP:0004386)2.14025464
133Abnormality of skeletal muscle fiber size (HP:0012084)2.13017973
134Duplicated collecting system (HP:0000081)2.12660772
135Renal cortical cysts (HP:0000803)2.11869279
136Anomalous pulmonary venous return (HP:0010772)2.10481401
137Progressive macrocephaly (HP:0004481)2.10240052
138Cerebral edema (HP:0002181)2.08259347
139Mitochondrial inheritance (HP:0001427)2.04516221
140Muscular dystrophy (HP:0003560)2.01906723
141Lactic acidosis (HP:0003128)2.01792355
142Alveolar cell carcinoma (HP:0006519)2.01382037
143Anorexia (HP:0002039)2.01055572
144Abnormality of the heme biosynthetic pathway (HP:0010472)2.01054141
145Polygenic inheritance (HP:0010982)1.99581929
146Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99420939
147Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99420939
148Hemorrhage of the eye (HP:0011885)1.98287435
149Hepatosplenomegaly (HP:0001433)1.98197293
150Axonal loss (HP:0003447)1.98126775
151Pancreatitis (HP:0001733)1.97599426
152Agitation (HP:0000713)1.95314240
153Abnormal rod and cone electroretinograms (HP:0008323)1.95035619
154Recurrent cutaneous fungal infections (HP:0011370)1.94962846
155Chronic mucocutaneous candidiasis (HP:0002728)1.94962846
156Petechiae (HP:0000967)1.94121453
157Pulmonary infiltrates (HP:0002113)1.92401701
158Chest pain (HP:0100749)1.91124627
159Growth hormone excess (HP:0000845)1.91022069
160Neonatal hypoglycemia (HP:0001998)1.90902091
161Gangrene (HP:0100758)1.90337854
162Hypoplasia of the iris (HP:0007676)1.89529762
163Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87889263
164Pulmonary embolism (HP:0002204)1.87216334
165Polyneuropathy (HP:0001271)1.85405227
166Renal Fanconi syndrome (HP:0001994)1.84531181
167Vertigo (HP:0002321)1.83999170
168Microcytic anemia (HP:0001935)1.82995812
169Abnormality of the pulmonary veins (HP:0011718)1.81093370
170Abnormality of the peritoneum (HP:0002585)1.77093865
171Myocardial infarction (HP:0001658)1.75173591
172Increased IgE level (HP:0003212)1.75146969
173Respiratory difficulties (HP:0002880)1.74533420
174Ragged-red muscle fibers (HP:0003200)1.74283020
175Leukocytosis (HP:0001974)1.73951162
1763-Methylglutaconic aciduria (HP:0003535)1.72309660
177Congenital malformation of the right heart (HP:0011723)1.71602161
178Double outlet right ventricle (HP:0001719)1.71602161
179Gastrointestinal stroma tumor (HP:0100723)1.69693957
180Arterial thrombosis (HP:0004420)1.68944922
181Congenital stationary night blindness (HP:0007642)1.65604269
182Epistaxis (HP:0000421)1.65395345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.30743950
2RIPK44.91762961
3MYLK3.87088607
4PDK23.84086961
5CSK3.04210734
6LMTK22.96599529
7FES2.84458914
8BCKDK2.76086372
9BLK2.75137586
10IRAK32.73344886
11TTN2.63408598
12TNK22.54827737
13PDK32.50804077
14PDK42.50804077
15ZAK2.30373868
16KDR2.19599726
17MAP3K112.12583231
18PIK3CA2.10429379
19INSRR2.05780161
20TSSK62.00669250
21TYK21.91513522
22CAMK1D1.90507965
23CDK91.84955672
24TXK1.80964956
25MATK1.80416068
26EPHA31.80412569
27PHKG21.74185673
28PHKG11.74185673
29EPHB21.68816567
30TGFBR21.67705988
31SIK11.61393500
32EPHA21.57797140
33STK161.50173292
34ARAF1.49603374
35MAP4K11.38841889
36MAP3K141.38739953
37SIK31.36901237
38FGR1.36832463
39ZAP701.33595888
40ABL21.32824458
41CAMKK21.32754492
42GRK51.30457388
43MAP3K31.29615084
44NME21.29463475
45BCR1.26336453
46MAP3K61.25138429
47MST1R1.24594755
48BTK1.22825176
49PIK3CG1.22223411
50RIPK11.20145760
51MARK21.19319597
52PRKAA21.19067838
53GRK61.13320415
54TAOK11.12644427
55MAPK151.12280491
56EIF2AK21.09274941
57FGFR41.08340153
58IRAK11.07876231
59LYN1.07736576
60LATS11.07730820
61MAPK121.04507953
62CAMK1G1.04385856
63FER1.02373209
64TAOK31.01607610
65STK111.01310143
66YES11.00864112
67SYK1.00384418
68TBK11.00146653
69MAP3K130.99171479
70HCK0.98784362
71OBSCN0.98735210
72MAP3K10.98444675
73CDK190.95296961
74PINK10.94010889
75MAP2K40.93081847
76MUSK0.90030679
77NUAK10.88945785
78KIT0.86351325
79STK38L0.85881535
80DYRK30.85671654
81LCK0.85631841
82LRRK20.85288339
83ADRBK10.83950658
84IRAK40.83608836
85PDK10.78945590
86EPHB10.78774710
87IKBKB0.75321577
88FGFR30.74107772
89CAMK10.73870189
90CASK0.73449736
91MAPKAPK30.72541523
92NTRK30.70757785
93PRKAA10.70713269
94NLK0.69995955
95MAP2K10.69826532
96AKT30.69646260
97BRAF0.69515250
98MAPK40.68809280
99GRK70.65348348
100SIK20.63603706
101JAK30.62869846
102GRK10.62761287
103NEK60.62553081
104PRKD10.62292606
105DMPK0.62193551
106WNK40.61586225
107KSR20.61358546
108TESK20.60424450
109JAK10.60035573
110CAMKK10.60007333
111IRAK20.59297609
112NME10.57416305
113ITK0.57206347
114DYRK1B0.56549592
115ADRBK20.56036628
116PRKCE0.55847900
117PRKCQ0.55116206
118PRKCD0.51481891
119MAP2K30.51383249
120CDK30.51329803
121BMPR20.49075865
122PRKCZ0.48313159
123FRK0.47762842
124CSF1R0.47320517
125FYN0.46414270
126PKN10.46057892
127MARK30.45765442
128TYRO30.44221441
129PRKACG0.43749527
130OXSR10.41811470
131PAK30.40310277
132MAPK70.39758419
133LATS20.39423476
134PRKG10.38768951
135DYRK20.37745667
136IGF1R0.37449555
137STK100.36410032
138PTK2B0.36205568
139MAP2K20.35529393
140CAMK2D0.35322025
141PRKG20.33199507
142TGFBR10.32185226
143TEC0.31894826
144PRKACA0.29405099
145TRPM70.29364204
146PRKD20.28253048
147CDC42BPA0.27979335
148ERN10.27042696
149TRIB30.25660858
150VRK10.25404780
151DAPK20.25233785
152JAK20.24578056
153MAP3K50.24363691
154IKBKE0.24156036
155CAMK40.23086802
156ERBB20.22324215
157PDPK10.22298674
158GSK3A0.20425740
159DAPK30.19747192

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.59426269
2Propanoate metabolism_Homo sapiens_hsa006404.16283881
3PPAR signaling pathway_Homo sapiens_hsa033203.98979249
4Fatty acid biosynthesis_Homo sapiens_hsa000613.62381736
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.37220806
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.34367272
7Fatty acid degradation_Homo sapiens_hsa000713.19523301
8Fatty acid metabolism_Homo sapiens_hsa012123.01851937
9Staphylococcus aureus infection_Homo sapiens_hsa051502.84628908
10Osteoclast differentiation_Homo sapiens_hsa043802.55425248
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.44210993
12Oxidative phosphorylation_Homo sapiens_hsa001902.39452784
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.26432346
14Parkinsons disease_Homo sapiens_hsa050122.15834153
15Dilated cardiomyopathy_Homo sapiens_hsa054142.04102037
16Fatty acid elongation_Homo sapiens_hsa000621.99435971
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.95575243
18Leishmaniasis_Homo sapiens_hsa051401.94340536
19Regulation of autophagy_Homo sapiens_hsa041401.88053390
20Cardiac muscle contraction_Homo sapiens_hsa042601.86608029
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.86414866
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.81980741
23Fat digestion and absorption_Homo sapiens_hsa049751.81199093
24beta-Alanine metabolism_Homo sapiens_hsa004101.75508621
25Alzheimers disease_Homo sapiens_hsa050101.68342413
26Pyruvate metabolism_Homo sapiens_hsa006201.65646197
27Tuberculosis_Homo sapiens_hsa051521.64641343
28Caffeine metabolism_Homo sapiens_hsa002321.64199670
29Glycerolipid metabolism_Homo sapiens_hsa005611.59128863
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.58821638
31Chemokine signaling pathway_Homo sapiens_hsa040621.57294023
32Huntingtons disease_Homo sapiens_hsa050161.57045228
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47371426
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46819544
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45768545
36Carbon metabolism_Homo sapiens_hsa012001.43783738
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37760547
38ECM-receptor interaction_Homo sapiens_hsa045121.37467198
39Histidine metabolism_Homo sapiens_hsa003401.37450086
40Phagosome_Homo sapiens_hsa041451.31695297
41Collecting duct acid secretion_Homo sapiens_hsa049661.26434877
42AMPK signaling pathway_Homo sapiens_hsa041521.24437560
43Legionellosis_Homo sapiens_hsa051341.22916820
44Allograft rejection_Homo sapiens_hsa053301.19839805
45Insulin resistance_Homo sapiens_hsa049311.16750065
46Peroxisome_Homo sapiens_hsa041461.16651633
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15627667
48B cell receptor signaling pathway_Homo sapiens_hsa046621.14463911
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.13910593
50Graft-versus-host disease_Homo sapiens_hsa053321.11377209
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.05208537
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03927042
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01724087
54Butanoate metabolism_Homo sapiens_hsa006501.00058905
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.97824176
56Acute myeloid leukemia_Homo sapiens_hsa052210.95729215
57Primary immunodeficiency_Homo sapiens_hsa053400.95535413
58Focal adhesion_Homo sapiens_hsa045100.93383661
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92930383
60Malaria_Homo sapiens_hsa051440.92872266
61Rheumatoid arthritis_Homo sapiens_hsa053230.92370432
62Morphine addiction_Homo sapiens_hsa050320.91884290
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88112217
64Lysosome_Homo sapiens_hsa041420.87845304
65African trypanosomiasis_Homo sapiens_hsa051430.84543498
66Pertussis_Homo sapiens_hsa051330.82862566
67Ribosome_Homo sapiens_hsa030100.81821066
68Platelet activation_Homo sapiens_hsa046110.79900134
69Dorso-ventral axis formation_Homo sapiens_hsa043200.79576416
70Galactose metabolism_Homo sapiens_hsa000520.78787260
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77408036
72Adherens junction_Homo sapiens_hsa045200.77342774
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76802647
74Salmonella infection_Homo sapiens_hsa051320.73447639
75Tryptophan metabolism_Homo sapiens_hsa003800.72925110
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72608826
77Viral myocarditis_Homo sapiens_hsa054160.70371660
78Sulfur metabolism_Homo sapiens_hsa009200.68415718
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68043343
80Insulin signaling pathway_Homo sapiens_hsa049100.67743256
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67618964
82Ovarian steroidogenesis_Homo sapiens_hsa049130.66939485
83Autoimmune thyroid disease_Homo sapiens_hsa053200.65718576
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65369216
85HIF-1 signaling pathway_Homo sapiens_hsa040660.65242628
86Arachidonic acid metabolism_Homo sapiens_hsa005900.64310083
87Hematopoietic cell lineage_Homo sapiens_hsa046400.63755921
88Olfactory transduction_Homo sapiens_hsa047400.62530237
89Measles_Homo sapiens_hsa051620.62238181
90Vitamin B6 metabolism_Homo sapiens_hsa007500.61683295
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61312155
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.60825982
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.59861432
94Asthma_Homo sapiens_hsa053100.59568383
95Phenylalanine metabolism_Homo sapiens_hsa003600.57587866
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.57228366
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56701483
98Vitamin digestion and absorption_Homo sapiens_hsa049770.56196385
99Toxoplasmosis_Homo sapiens_hsa051450.55919031
100ABC transporters_Homo sapiens_hsa020100.55448997
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55041309
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.54819850
103Other glycan degradation_Homo sapiens_hsa005110.54473838
104Shigellosis_Homo sapiens_hsa051310.53059747
105Starch and sucrose metabolism_Homo sapiens_hsa005000.52891184
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52472257
107Taste transduction_Homo sapiens_hsa047420.51411706
108Influenza A_Homo sapiens_hsa051640.51321347
109Tyrosine metabolism_Homo sapiens_hsa003500.49891946
110Renin secretion_Homo sapiens_hsa049240.48903639
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48423649
112Type I diabetes mellitus_Homo sapiens_hsa049400.47692303
113Glucagon signaling pathway_Homo sapiens_hsa049220.47654986
114Type II diabetes mellitus_Homo sapiens_hsa049300.47311098
115T cell receptor signaling pathway_Homo sapiens_hsa046600.45531140
116cAMP signaling pathway_Homo sapiens_hsa040240.45105030
117Linoleic acid metabolism_Homo sapiens_hsa005910.44303240
118Small cell lung cancer_Homo sapiens_hsa052220.43237274
119Amoebiasis_Homo sapiens_hsa051460.42134346
120Tight junction_Homo sapiens_hsa045300.41745314
121Folate biosynthesis_Homo sapiens_hsa007900.40959694
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40270099
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40189484
124TNF signaling pathway_Homo sapiens_hsa046680.39261596
125Notch signaling pathway_Homo sapiens_hsa043300.39223307
126Calcium signaling pathway_Homo sapiens_hsa040200.39116893
127Pentose phosphate pathway_Homo sapiens_hsa000300.38662894
128Ether lipid metabolism_Homo sapiens_hsa005650.38620240
129Endocytosis_Homo sapiens_hsa041440.38480116
130FoxO signaling pathway_Homo sapiens_hsa040680.37877583
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36304789
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35604625
133Metabolic pathways_Homo sapiens_hsa011000.33008914
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32978684
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31359036
136Protein digestion and absorption_Homo sapiens_hsa049740.30683442
137Circadian rhythm_Homo sapiens_hsa047100.30519811
138Prolactin signaling pathway_Homo sapiens_hsa049170.30025981
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29556015
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29078042
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28865713
142Arginine and proline metabolism_Homo sapiens_hsa003300.25627112
143Pathways in cancer_Homo sapiens_hsa052000.24924243
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.22157470
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22004503
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21529812
147Sulfur relay system_Homo sapiens_hsa041220.20993826
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.18905853
149Hepatitis C_Homo sapiens_hsa051600.17470025
150Lysine degradation_Homo sapiens_hsa003100.16323837
151Maturity onset diabetes of the young_Homo sapiens_hsa049500.13043060
152Fructose and mannose metabolism_Homo sapiens_hsa000510.11336839
153Rap1 signaling pathway_Homo sapiens_hsa040150.10590533

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