RBPJ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.88470230
2regulation of meiosis I (GO:0060631)4.40397114
3negative regulation of DNA-dependent DNA replication (GO:2000104)4.32811230
4negative regulation of translation, ncRNA-mediated (GO:0040033)4.19699500
5regulation of translation, ncRNA-mediated (GO:0045974)4.19699500
6negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.19699500
7presynaptic membrane organization (GO:0097090)4.16964823
8presynaptic membrane assembly (GO:0097105)4.14696350
9nuclear pore complex assembly (GO:0051292)4.07877923
10replication fork processing (GO:0031297)4.05569295
11nuclear pore organization (GO:0006999)4.01631773
12regulation of DNA endoreduplication (GO:0032875)3.85025625
13neural tube formation (GO:0001841)3.79155308
14limb bud formation (GO:0060174)3.70564062
15kidney morphogenesis (GO:0060993)3.60607409
16olfactory bulb development (GO:0021772)3.59734739
17chromatin remodeling at centromere (GO:0031055)3.51681121
18resolution of meiotic recombination intermediates (GO:0000712)3.49798331
19negative regulation of DNA recombination (GO:0045910)3.45063410
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.44527283
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.44527283
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.44527283
23modulation by symbiont of host immune response (GO:0052553)3.44527283
24positive regulation by symbiont of host defense response (GO:0052509)3.44527283
25modulation by symbiont of host defense response (GO:0052031)3.44527283
26regulation of nuclear cell cycle DNA replication (GO:0033262)3.43648057
27CENP-A containing nucleosome assembly (GO:0034080)3.31909785
28pore complex assembly (GO:0046931)3.30919087
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.30618729
30synapsis (GO:0007129)3.29086862
31histone exchange (GO:0043486)3.26814497
32regulation of collateral sprouting (GO:0048670)3.25133227
33DNA catabolic process, exonucleolytic (GO:0000738)3.24080373
34regulation of telomere maintenance (GO:0032204)3.20551944
35DNA ligation (GO:0006266)3.17474307
36maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.15883429
37somite development (GO:0061053)3.14261605
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.12168300
39forebrain neuron differentiation (GO:0021879)3.11495107
40nonmotile primary cilium assembly (GO:0035058)3.03581489
41negative regulation of meiosis (GO:0045835)3.03567685
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.02533979
43mitotic nuclear envelope disassembly (GO:0007077)3.00140094
44DNA replication-independent nucleosome assembly (GO:0006336)2.99463323
45DNA replication-independent nucleosome organization (GO:0034724)2.99463323
46regulation of non-canonical Wnt signaling pathway (GO:2000050)2.95690568
47response to X-ray (GO:0010165)2.94773946
48negative regulation of interleukin-12 production (GO:0032695)2.94633984
49somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.94586246
50somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.94586246
51isotype switching (GO:0045190)2.94586246
52positive regulation of gamma-delta T cell activation (GO:0046645)2.94176603
53histone H2A acetylation (GO:0043968)2.94075616
54acrosome assembly (GO:0001675)2.93426817
55response to peptidoglycan (GO:0032494)2.90438960
56establishment of integrated proviral latency (GO:0075713)2.89945424
57centriole replication (GO:0007099)2.88861920
58protein localization to kinetochore (GO:0034501)2.88332158
59tolerance induction (GO:0002507)2.87836838
60positive regulation of male gonad development (GO:2000020)2.86421729
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.84925528
62telomere maintenance via telomerase (GO:0007004)2.83348637
63regulation of interleukin-12 biosynthetic process (GO:0045075)2.82877688
64DNA damage response, detection of DNA damage (GO:0042769)2.82800128
65regulation of interferon-alpha production (GO:0032647)2.82765045
66single strand break repair (GO:0000012)2.81914321
67regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.81435083
68pyrimidine nucleobase catabolic process (GO:0006208)2.80896195
69tyrosine phosphorylation of STAT protein (GO:0007260)2.79511216
70nuclear envelope disassembly (GO:0051081)2.79282037
71membrane disassembly (GO:0030397)2.79282037
72DNA deamination (GO:0045006)2.78853939
73positive regulation of interferon-alpha production (GO:0032727)2.77515555
74mitotic G2/M transition checkpoint (GO:0044818)2.76544641
75otic vesicle formation (GO:0030916)2.75816874
76photoreceptor cell maintenance (GO:0045494)2.75104267
77recombinational repair (GO:0000725)2.74827497
78immunoglobulin mediated immune response (GO:0016064)2.74223881
79B cell mediated immunity (GO:0019724)2.73483911
80microtubule depolymerization (GO:0007019)2.73457208
81double-strand break repair via homologous recombination (GO:0000724)2.70785412
82NIK/NF-kappaB signaling (GO:0038061)2.70490207
83DNA unwinding involved in DNA replication (GO:0006268)2.69655478
84regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69375103
85regulation of mitotic spindle checkpoint (GO:1903504)2.69375103
86positive regulation of natural killer cell differentiation (GO:0032825)2.67355153
87positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.67133009
88protein polyglutamylation (GO:0018095)2.66980629
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66636346
90cell proliferation in forebrain (GO:0021846)2.66327503
91protein neddylation (GO:0045116)2.65374086
92DNA demethylation (GO:0080111)2.65035173
93cerebral cortex radially oriented cell migration (GO:0021799)2.63412762
94folic acid-containing compound biosynthetic process (GO:0009396)2.62682497
95detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60763099
96non-recombinational repair (GO:0000726)2.59092134
97double-strand break repair via nonhomologous end joining (GO:0006303)2.59092134
98positive regulation of SMAD protein import into nucleus (GO:0060391)2.59006503
99prenylation (GO:0097354)2.58323625
100protein prenylation (GO:0018342)2.58323625
101nucleobase biosynthetic process (GO:0046112)2.57803051
102regulation of integrin activation (GO:0033623)2.57770449
103central nervous system projection neuron axonogenesis (GO:0021952)2.57211818
104somatic hypermutation of immunoglobulin genes (GO:0016446)2.56770964
105somatic diversification of immune receptors via somatic mutation (GO:0002566)2.56770964
106regulation of posttranscriptional gene silencing (GO:0060147)2.56653699
107regulation of gene silencing by miRNA (GO:0060964)2.56653699
108regulation of gene silencing by RNA (GO:0060966)2.56653699
109negative regulation of axon guidance (GO:1902668)2.54319883
110neutrophil activation involved in immune response (GO:0002283)2.53802757
111natural killer cell mediated immunity (GO:0002228)2.53254531
112natural killer cell mediated cytotoxicity (GO:0042267)2.53254531
113regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.53020289
114Sertoli cell development (GO:0060009)2.52417708
115negative regulation of B cell proliferation (GO:0030889)2.52231484
116regulation of interferon-beta biosynthetic process (GO:0045357)2.51420854
117heterochromatin organization (GO:0070828)2.51416360
118regulation of mitotic spindle organization (GO:0060236)2.51039584
119protein localization to chromosome, centromeric region (GO:0071459)2.50918590
120response to muramyl dipeptide (GO:0032495)2.50815011
121positive regulation of dendritic spine morphogenesis (GO:0061003)2.50548367
122negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.50509102
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.50509102
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.50509102
125negative regulation of sister chromatid segregation (GO:0033046)2.50509102
126negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.50509102
127DNA-dependent DNA replication (GO:0006261)2.49132787
128mitotic spindle checkpoint (GO:0071174)2.49083576
129trophoblast giant cell differentiation (GO:0060707)2.49031105
130mitotic metaphase plate congression (GO:0007080)2.46322242
131mitotic G2 DNA damage checkpoint (GO:0007095)2.46261321
132regulation of helicase activity (GO:0051095)2.45982278
133adaptation of signaling pathway (GO:0023058)2.45822440
134intraciliary transport (GO:0042073)2.45618644
135pinocytosis (GO:0006907)2.44244288
136positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.43872667
137ganglion development (GO:0061548)2.43416706
138positive regulation of protein import into nucleus, translocation (GO:0033160)2.41776814
139regulation of male gonad development (GO:2000018)2.40559410
140postsynaptic membrane organization (GO:0001941)2.40451993
141spindle checkpoint (GO:0031577)2.40070287
142microtubule anchoring (GO:0034453)2.39756257
143regulation of spindle organization (GO:0090224)2.39313716
144positive regulation of interferon-beta production (GO:0032728)2.39296274
145cilium morphogenesis (GO:0060271)2.39249118
146positive regulation of lymphocyte apoptotic process (GO:0070230)2.38705656
147regulation of interleukin-2 biosynthetic process (GO:0045076)2.37752360
148positive regulation of chromosome segregation (GO:0051984)2.35942956
149regulation of alpha-beta T cell proliferation (GO:0046640)2.35138970
150positive regulation of alpha-beta T cell proliferation (GO:0046641)2.32565655
151DNA geometric change (GO:0032392)2.30936176
152negative regulation of histone methylation (GO:0031061)2.30888682
153positive regulation of mitotic sister chromatid separation (GO:1901970)2.29354313
154positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.29354313
155positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.29354313
156NLS-bearing protein import into nucleus (GO:0006607)2.29210164
157regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.29201378
158DNA duplex unwinding (GO:0032508)2.28887458
159pre-miRNA processing (GO:0031054)2.28108188
160DNA replication initiation (GO:0006270)2.27577802
161myeloid dendritic cell differentiation (GO:0043011)2.27200965
162negative T cell selection (GO:0043383)2.27098357
163Arp2/3 complex-mediated actin nucleation (GO:0034314)2.25013924
164modulation by symbiont of host cellular process (GO:0044068)2.24688707
165T cell apoptotic process (GO:0070231)2.23742080
166regulation of histone H3-K9 methylation (GO:0051570)2.23734961
167negative thymic T cell selection (GO:0045060)2.23705121
168mitotic sister chromatid cohesion (GO:0007064)2.22883228
169regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.22267188
170positive regulation of interleukin-17 production (GO:0032740)2.21836870
171IMP biosynthetic process (GO:0006188)2.20888222
172cellular response to interferon-alpha (GO:0035457)2.20637200
173DNA replication-dependent nucleosome assembly (GO:0006335)2.20331562
174DNA replication-dependent nucleosome organization (GO:0034723)2.20331562
175regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.20190781
176determination of adult lifespan (GO:0008340)2.19946387
177regulation of SMAD protein import into nucleus (GO:0060390)2.17685914
178myeloid dendritic cell activation (GO:0001773)2.16816059
179nuclear envelope organization (GO:0006998)2.16591137
180regulation of interleukin-12 production (GO:0032655)2.16578430
181regulation of RNA export from nucleus (GO:0046831)2.15983438
182production of molecular mediator involved in inflammatory response (GO:0002532)2.14559755
183kinetochore organization (GO:0051383)2.14256414
184establishment of chromosome localization (GO:0051303)2.14109799
185positive regulation of B cell differentiation (GO:0045579)2.14108035
186interferon-gamma production (GO:0032609)2.13284395
187positive regulation of leukocyte apoptotic process (GO:2000108)2.13254132
188response to UV-C (GO:0010225)2.11111242
189dosage compensation (GO:0007549)2.10927643
190positive regulation of T cell apoptotic process (GO:0070234)2.10811880
191JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.10234727
192metaphase plate congression (GO:0051310)2.09958531
193positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.09646629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.24211930
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.13273299
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.08898844
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.34718110
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.08102792
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.07333808
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.85243576
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84476455
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78502254
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.76041076
11GBX2_23144817_ChIP-Seq_PC3_Human2.70297364
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.68200243
13VDR_22108803_ChIP-Seq_LS180_Human2.67492534
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64236547
15TAF15_26573619_Chip-Seq_HEK293_Human2.57506703
16EWS_26573619_Chip-Seq_HEK293_Human2.54905389
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53990397
18FUS_26573619_Chip-Seq_HEK293_Human2.53195471
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.47820873
20ZNF274_21170338_ChIP-Seq_K562_Hela2.42451500
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.38826476
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31415005
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28758130
24P300_19829295_ChIP-Seq_ESCs_Human2.28747190
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.22493628
26IGF1R_20145208_ChIP-Seq_DFB_Human2.19594369
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14342711
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.06320638
29* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05292804
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04476672
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.04023046
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.04023046
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.04023046
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97719822
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.97045592
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95671328
37* IRF8_27001747_Chip-Seq_BMDM_Mouse1.93503096
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.90801689
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87057602
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84924138
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84637692
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84323526
43MYC_22102868_ChIP-Seq_BL_Human1.83428611
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82350970
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82150183
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78558100
47* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.77956191
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76131816
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75657604
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74995943
51* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74463107
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72854274
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71406021
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70145860
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69968484
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69026340
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68749717
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.68185255
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.64065381
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61938413
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61337298
62* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60314502
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59083801
64* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58435648
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57982583
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56467322
67* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54328526
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.52226935
69* SPI1_23547873_ChIP-Seq_NB4_Human1.52206024
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52074541
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51954944
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.51046895
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.50835058
74AR_21909140_ChIP-Seq_LNCAP_Human1.50799823
75MYB_26560356_Chip-Seq_TH2_Human1.49693977
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49669688
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.49631471
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49147392
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49147392
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48400979
81* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47730082
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46636536
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45656178
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45634238
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43977413
86VDR_21846776_ChIP-Seq_THP-1_Human1.43860039
87TFEB_21752829_ChIP-Seq_HELA_Human1.42898503
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42711623
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42693393
90MAF_26560356_Chip-Seq_TH1_Human1.41566325
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.41267042
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39521679
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39113931
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38557668
95ELK1_19687146_ChIP-ChIP_HELA_Human1.37846490
96MYB_26560356_Chip-Seq_TH1_Human1.35604311
97BCAT_22108803_ChIP-Seq_LS180_Human1.35578089
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35551925
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34882791
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.34135525
101ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31610787
102* STAT3_23295773_ChIP-Seq_U87_Human1.29515407
103ER_23166858_ChIP-Seq_MCF-7_Human1.28530414
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.27510280
105CBP_20019798_ChIP-Seq_JUKART_Human1.26851530
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26851530
107EZH2_22144423_ChIP-Seq_EOC_Human1.25322855
108MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24414560
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24071339
110XRN2_22483619_ChIP-Seq_HELA_Human1.23609127
111* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22097586
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.21713839
113VDR_23849224_ChIP-Seq_CD4+_Human1.21336544
114MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20501922
115TCF4_22108803_ChIP-Seq_LS180_Human1.20334388
116RUNX1_22412390_ChIP-Seq_EML_Mouse1.18547506
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18214604
118MYC_18940864_ChIP-ChIP_HL60_Human1.17757063
119AR_25329375_ChIP-Seq_VCAP_Human1.17027749
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16738945
121NANOG_19829295_ChIP-Seq_ESCs_Human1.15582484
122SOX2_19829295_ChIP-Seq_ESCs_Human1.15582484
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.14913697
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14353562
125* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14331966
126HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14117316
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13832487
128NANOG_16153702_ChIP-ChIP_HESCs_Human1.13747638
129SOX2_16153702_ChIP-ChIP_HESCs_Human1.13632473
130RUNX2_22187159_ChIP-Seq_PCA_Human1.13474729
131P53_22387025_ChIP-Seq_ESCs_Mouse1.13196380
132MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12875943
133AR_21572438_ChIP-Seq_LNCaP_Human1.12630594
134EST1_17652178_ChIP-ChIP_JURKAT_Human1.12187024
135SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11624250
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11622999
137TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10782421
138* TCF4_23295773_ChIP-Seq_U87_Human1.10671397
139PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10197158
140KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10052628
141UTX_26944678_Chip-Seq_JUKART_Human1.09309046
142CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09191451
143E2F1_18555785_Chip-Seq_ESCs_Mouse1.08495889
144* RNF2_27304074_Chip-Seq_NSC_Mouse1.08429530
145SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08167606
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08085650
147HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06876081
148CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06424804
149TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06409508
150TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05945241
151NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05748215
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05558958
153TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05470963
154KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05455508
155SOX9_26525672_Chip-Seq_HEART_Mouse1.05437666
156CMYC_18555785_Chip-Seq_ESCs_Mouse1.04879720
157PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04298383
158* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03263812
159HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03140129
160PRDM14_20953172_ChIP-Seq_ESCs_Human1.02514277
161P300_18555785_Chip-Seq_ESCs_Mouse1.02323970
162WT1_19549856_ChIP-ChIP_CCG9911_Human1.01684526
163PU_27001747_Chip-Seq_BMDM_Mouse1.01343325
164* TCF7_22412390_ChIP-Seq_EML_Mouse1.00766013
165VDR_24763502_ChIP-Seq_THP-1_Human0.99276727
166E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97907791
167RUNX_20019798_ChIP-Seq_JUKART_Human0.97216186
168NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96529646
169CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95973248
170KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93962488
171TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93634275
172* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93405667
173* KDM5A_27292631_Chip-Seq_BREAST_Human0.92999987
174DCP1A_22483619_ChIP-Seq_HELA_Human0.92779929
175* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92167532
176ETS1_20019798_ChIP-Seq_JURKAT_Human0.91978862
177* TTF2_22483619_ChIP-Seq_HELA_Human0.91493052
178FOXP3_21729870_ChIP-Seq_TREG_Human0.91007334
179NOTCH1_21737748_ChIP-Seq_TLL_Human0.90215963
180* MAF_26560356_Chip-Seq_TH2_Human0.90134035
181PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89305885
182ELK3_25401928_ChIP-Seq_HUVEC_Human0.86769519
183CIITA_25753668_ChIP-Seq_RAJI_Human0.86618644
184POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86368535
185GABP_17652178_ChIP-ChIP_JURKAT_Human0.86256752
186* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83116588
187* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83116588
188* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83102046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.74382617
2MP0006292_abnormal_olfactory_placode2.99364544
3MP0001835_abnormal_antigen_presentation2.79877576
4MP0003436_decreased_susceptibility_to2.69788134
5MP0010352_gastrointestinal_tract_polyps2.67864468
6MP0002102_abnormal_ear_morphology2.60333210
7MP0003787_abnormal_imprinting2.54422185
8MP0008057_abnormal_DNA_replication2.49967363
9MP0003890_abnormal_embryonic-extraembry2.49261418
10MP0001188_hyperpigmentation2.48508982
11MP0003303_peritoneal_inflammation2.44040392
12MP0010307_abnormal_tumor_latency2.36712522
13MP0003693_abnormal_embryo_hatching2.25411155
14MP0003111_abnormal_nucleus_morphology2.24973593
15MP0004742_abnormal_vestibular_system2.23630889
16MP0000685_abnormal_immune_system2.20501895
17MP0000778_abnormal_nervous_system2.20396244
18MP0004885_abnormal_endolymph2.18165354
19MP0005000_abnormal_immune_tolerance2.13414581
20MP0002751_abnormal_autonomic_nervous2.12871183
21MP0003077_abnormal_cell_cycle2.12246426
22MP0010094_abnormal_chromosome_stability2.12044437
23MP0001790_abnormal_immune_system2.04802192
24MP0005387_immune_system_phenotype2.04802192
25MP0003880_abnormal_central_pattern2.03846775
26MP0001485_abnormal_pinna_reflex2.03782503
27MP0005671_abnormal_response_to2.01405252
28MP0000569_abnormal_digit_pigmentation2.01055201
29MP0009785_altered_susceptibility_to1.99496685
30* MP0001800_abnormal_humoral_immune1.96782825
31MP0002148_abnormal_hypersensitivity_rea1.96696509
32MP0006082_CNS_inflammation1.96511691
33MP0006072_abnormal_retinal_apoptosis1.94954887
34MP0009333_abnormal_splenocyte_physiolog1.94904598
35MP0008789_abnormal_olfactory_epithelium1.94714919
36MP0002452_abnormal_antigen_presenting1.93197594
37MP0003121_genomic_imprinting1.93114240
38MP0003300_gastrointestinal_ulcer1.92517121
39* MP0005076_abnormal_cell_differentiation1.89410778
40MP0001177_atelectasis1.85894917
41MP0008007_abnormal_cellular_replicative1.85614489
42MP0002736_abnormal_nociception_after1.84931515
43MP0009278_abnormal_bone_marrow1.82798135
44* MP0003448_altered_tumor_morphology1.81016673
45MP0004957_abnormal_blastocyst_morpholog1.80750444
46MP0002405_respiratory_system_inflammati1.79930427
47MP0002419_abnormal_innate_immunity1.79473429
48* MP0005025_abnormal_response_to1.73857656
49MP0002938_white_spotting1.73398318
50* MP0002723_abnormal_immune_serum1.72024059
51MP0001486_abnormal_startle_reflex1.71947375
52MP0005551_abnormal_eye_electrophysiolog1.66978228
53MP0003705_abnormal_hypodermis_morpholog1.66733802
54MP0000049_abnormal_middle_ear1.65242105
55MP0001819_abnormal_immune_cell1.63446791
56MP0002420_abnormal_adaptive_immunity1.62582217
57MP0000858_altered_metastatic_potential1.62493893
58MP0003566_abnormal_cell_adhesion1.60153432
59MP0001529_abnormal_vocalization1.57532187
60MP0005367_renal/urinary_system_phenotyp1.57391350
61MP0000516_abnormal_urinary_system1.57391350
62MP0005084_abnormal_gallbladder_morpholo1.56858956
63MP0004808_abnormal_hematopoietic_stem1.56676361
64MP0002396_abnormal_hematopoietic_system1.56541218
65MP0002233_abnormal_nose_morphology1.56240765
66MP0001853_heart_inflammation1.55925856
67MP0001968_abnormal_touch/_nociception1.54002781
68MP0003937_abnormal_limbs/digits/tail_de1.51800747
69* MP0002398_abnormal_bone_marrow1.50874508
70MP0000350_abnormal_cell_proliferation1.49882159
71MP0001984_abnormal_olfaction1.46526070
72MP0010155_abnormal_intestine_physiology1.43946232
73MP0002006_tumorigenesis1.43663981
74MP0005397_hematopoietic_system_phenotyp1.42968306
75MP0001545_abnormal_hematopoietic_system1.42968306
76MP0005253_abnormal_eye_physiology1.42600682
77MP0003941_abnormal_skin_development1.42572831
78* MP0003567_abnormal_fetal_cardiomyocyte1.41877342
79MP0003763_abnormal_thymus_physiology1.38411889
80MP0001533_abnormal_skeleton_physiology1.36062450
81MP0004947_skin_inflammation1.35845556
82MP0003724_increased_susceptibility_to1.35338467
83* MP0000716_abnormal_immune_system1.34425200
84MP0008058_abnormal_DNA_repair1.33418546
85MP0005023_abnormal_wound_healing1.32326991
86* MP0000689_abnormal_spleen_morphology1.31581960
87MP0003011_delayed_dark_adaptation1.31086346
88MP0005499_abnormal_olfactory_system1.31067975
89MP0005394_taste/olfaction_phenotype1.31067975
90MP0001286_abnormal_eye_development1.30680589
91MP0003136_yellow_coat_color1.30457662
92* MP0002722_abnormal_immune_system1.29411065
93MP0002166_altered_tumor_susceptibility1.26417168
94MP0004510_myositis1.24956262
95* MP0000490_abnormal_crypts_of1.21377014
96* MP0000703_abnormal_thymus_morphology1.20195710
97MP0000631_abnormal_neuroendocrine_gland1.20075965
98* MP0002429_abnormal_blood_cell1.18222031
99MP0008932_abnormal_embryonic_tissue1.15468099
100MP0001730_embryonic_growth_arrest1.14578943
101MP0002837_dystrophic_cardiac_calcinosis1.13530147
102MP0001845_abnormal_inflammatory_respons1.12970231
103MP0003718_maternal_effect1.12691596
104MP0003938_abnormal_ear_development1.10154506
105MP0004142_abnormal_muscle_tone1.09534966
106MP0003091_abnormal_cell_migration1.08598294
107MP0002019_abnormal_tumor_incidence1.07327078
108MP0002933_joint_inflammation1.06118966
109MP0008438_abnormal_cutaneous_collagen1.05362928
110MP0001915_intracranial_hemorrhage1.05307684
111MP0004133_heterotaxia1.04931984
112MP0004215_abnormal_myocardial_fiber1.04588746
113* MP0002086_abnormal_extraembryonic_tissu1.04476586
114* MP0003861_abnormal_nervous_system1.04442416
115MP0002067_abnormal_sensory_capabilities1.03204121
116* MP0000733_abnormal_muscle_development1.02784866
117MP0002653_abnormal_ependyma_morphology1.02575645
118MP0003755_abnormal_palate_morphology1.02566450
119MP0005058_abnormal_lysosome_morphology1.02350750
120MP0002277_abnormal_respiratory_mucosa1.01361593
121MP0002282_abnormal_trachea_morphology1.00608204
122MP0004197_abnormal_fetal_growth/weight/1.00211079
123MP0003119_abnormal_digestive_system0.99675352
124* MP0005380_embryogenesis_phenotype0.97108531
125* MP0001672_abnormal_embryogenesis/_devel0.97108531
126* MP0000627_abnormal_mammary_gland0.96878734
127MP0005464_abnormal_platelet_physiology0.96849305
128MP0003453_abnormal_keratinocyte_physiol0.96741667
129MP0002752_abnormal_somatic_nervous0.95766647
130MP0001697_abnormal_embryo_size0.95197725
131MP0009703_decreased_birth_body0.94771593
132MP0000343_altered_response_to0.93964349
133MP0002210_abnormal_sex_determination0.93814903
134MP0003984_embryonic_growth_retardation0.93783390
135MP0002095_abnormal_skin_pigmentation0.92794222
136MP0005310_abnormal_salivary_gland0.92088749
137MP0002877_abnormal_melanocyte_morpholog0.91695414
138MP0000372_irregular_coat_pigmentation0.91449379
139MP0000313_abnormal_cell_death0.91193520
140* MP0002088_abnormal_embryonic_growth/wei0.90282977
141MP0002272_abnormal_nervous_system0.90137325
142MP0002735_abnormal_chemical_nociception0.89874872
143MP0003828_pulmonary_edema0.89594412
144MP0005195_abnormal_posterior_eye0.89145528
145MP0009250_abnormal_appendicular_skeleto0.89109809
146MP0001145_abnormal_male_reproductive0.88230799
147MP0001873_stomach_inflammation0.88174436
148MP0001929_abnormal_gametogenesis0.87497237
149MP0006276_abnormal_autonomic_nervous0.86427331
150MP0000647_abnormal_sebaceous_gland0.86146655
151MP0000653_abnormal_sex_gland0.85700508
152MP0005390_skeleton_phenotype0.85471192
153MP0000428_abnormal_craniofacial_morphol0.85345770
154MP0005391_vision/eye_phenotype0.84534921
155MP0001963_abnormal_hearing_physiology0.84372943
156MP0002084_abnormal_developmental_patter0.83823465
157MP0000432_abnormal_head_morphology0.83640924
158MP0003172_abnormal_lysosome_physiology0.83324926
159MP0000465_gastrointestinal_hemorrhage0.83315030
160* MP0002085_abnormal_embryonic_tissue0.83221361
161MP0000427_abnormal_hair_cycle0.82316103
162MP0003385_abnormal_body_wall0.82057975
163* MP0002080_prenatal_lethality0.79405971
164MP0002998_abnormal_bone_remodeling0.79376862
165MP0005377_hearing/vestibular/ear_phenot0.77508599
166MP0003878_abnormal_ear_physiology0.77508599
167MP0005623_abnormal_meninges_morphology0.76627452
168MP0002177_abnormal_outer_ear0.75244526
169* MP0005621_abnormal_cell_physiology0.74573641
170MP0001119_abnormal_female_reproductive0.74527041
171MP0002109_abnormal_limb_morphology0.74424941
172MP0005257_abnormal_intraocular_pressure0.74215639
173MP0000026_abnormal_inner_ear0.73628473
174MP0002734_abnormal_mechanical_nocicepti0.73598131
175MP0005174_abnormal_tail_pigmentation0.73417413
176MP0002063_abnormal_learning/memory/cond0.72824655
177MP0002152_abnormal_brain_morphology0.72551191
178MP0000534_abnormal_ureter_morphology0.72125685
179MP0008995_early_reproductive_senescence0.72051803
180MP0009745_abnormal_behavioral_response0.71879111
181MP0009053_abnormal_anal_canal0.71690487
182MP0001849_ear_inflammation0.71343718
183MP0003950_abnormal_plasma_membrane0.71167341
184MP0001293_anophthalmia0.69769777

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.03121002
2Volvulus (HP:0002580)4.00189431
3Retrobulbar optic neuritis (HP:0100654)3.76441062
4Optic neuritis (HP:0100653)3.76441062
5Recurrent abscess formation (HP:0002722)3.67831263
6Orchitis (HP:0100796)3.51232200
7Myositis (HP:0100614)3.43056436
8Stomatitis (HP:0010280)3.34027073
9Agnosia (HP:0010524)3.23190332
10Septo-optic dysplasia (HP:0100842)3.17943417
11Mediastinal lymphadenopathy (HP:0100721)3.08569660
12Colon cancer (HP:0003003)3.00650440
13Recurrent bacterial skin infections (HP:0005406)2.96676485
14Amaurosis fugax (HP:0100576)2.89422735
15Drooling (HP:0002307)2.87623109
16Elevated erythrocyte sedimentation rate (HP:0003565)2.86000251
17Abnormal hair whorl (HP:0010721)2.85222143
18Nephronophthisis (HP:0000090)2.84304924
19Recurrent fungal infections (HP:0002841)2.83176992
20Pancreatic cysts (HP:0001737)2.79680448
21Pancreatic fibrosis (HP:0100732)2.75515133
22Abnormality of midbrain morphology (HP:0002418)2.75044110
23Molar tooth sign on MRI (HP:0002419)2.75044110
24Abnormality of macrophages (HP:0004311)2.74730442
25Chromsome breakage (HP:0040012)2.70364008
26Arterial thrombosis (HP:0004420)2.69754610
27Prostate neoplasm (HP:0100787)2.68604750
28True hermaphroditism (HP:0010459)2.67685922
29Excessive salivation (HP:0003781)2.66014945
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.65986170
31Osteolytic defects of the hand bones (HP:0009699)2.65986170
32Intestinal atresia (HP:0011100)2.65430982
33Obstructive lung disease (HP:0006536)2.61975166
34Chronic obstructive pulmonary disease (HP:0006510)2.61975166
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56338448
36Medial flaring of the eyebrow (HP:0010747)2.55662530
37Cortical dysplasia (HP:0002539)2.53367821
38Recurrent viral infections (HP:0004429)2.53326221
39Methylmalonic acidemia (HP:0002912)2.53238410
40Genital tract atresia (HP:0001827)2.51784231
41Abnormal lung lobation (HP:0002101)2.51377962
42Increased density of long bones (HP:0006392)2.50189238
43Vaginal atresia (HP:0000148)2.45828691
44Abnormality of the renal medulla (HP:0100957)2.40604642
45Glioma (HP:0009733)2.38981157
46Abolished electroretinogram (ERG) (HP:0000550)2.36818570
47Supernumerary spleens (HP:0009799)2.34785112
48Myocardial infarction (HP:0001658)2.34656198
49Abnormality of the ileum (HP:0001549)2.33020537
50Ependymoma (HP:0002888)2.32078522
51Pulmonary infiltrates (HP:0002113)2.27656260
52Selective tooth agenesis (HP:0001592)2.26932544
53Rectovaginal fistula (HP:0000143)2.26852879
54Rectal fistula (HP:0100590)2.26852879
55Protruding tongue (HP:0010808)2.22302316
56Ectopic kidney (HP:0000086)2.20591315
57Aplasia/Hypoplasia of the sternum (HP:0006714)2.20366717
58T lymphocytopenia (HP:0005403)2.18184918
59Gonadotropin excess (HP:0000837)2.17709973
60Abnormality of T cell number (HP:0011839)2.17391188
61Vasculitis (HP:0002633)2.15047225
62Carpal bone hypoplasia (HP:0001498)2.14268542
63Absent speech (HP:0001344)2.13110385
64Birth length less than 3rd percentile (HP:0003561)2.12521376
65Spinal cord lesions (HP:0100561)2.11648700
66Syringomyelia (HP:0003396)2.11648700
67Periodontitis (HP:0000704)2.11100262
68IgA deficiency (HP:0002720)2.10730259
69Persistence of primary teeth (HP:0006335)2.10501784
70Cupped ear (HP:0000378)2.09620169
71Bifid tongue (HP:0010297)2.09580705
72Keratoconjunctivitis sicca (HP:0001097)2.09248406
73Papillary thyroid carcinoma (HP:0002895)2.09035228
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08595091
75Gait imbalance (HP:0002141)2.08242847
76Optic nerve hypoplasia (HP:0000609)2.05238223
77Leukocytosis (HP:0001974)2.05230123
78Recurrent cutaneous fungal infections (HP:0011370)2.05154082
79Chronic mucocutaneous candidiasis (HP:0002728)2.05154082
80Gingivitis (HP:0000230)2.04811235
81Disinhibition (HP:0000734)2.04662523
82Thrombocytosis (HP:0001894)2.04395760
83Hypoproteinemia (HP:0003075)2.04387685
84Congenital primary aphakia (HP:0007707)2.03276634
85Abnormality of the septum pellucidum (HP:0007375)2.01628419
86Narrow forehead (HP:0000341)2.00655150
87Abnormality of the phalanges of the 2nd finger (HP:0009541)1.97970951
88Renal cortical cysts (HP:0000803)1.97025567
89Keratoconjunctivitis (HP:0001096)1.96586131
90Abnormality of the renal cortex (HP:0011035)1.96536662
91Abnormality of the peritoneum (HP:0002585)1.96454879
92Recurrent skin infections (HP:0001581)1.95906281
93Postaxial foot polydactyly (HP:0001830)1.95644110
94Progressive cerebellar ataxia (HP:0002073)1.94980865
95Hematochezia (HP:0002573)1.94512735
96Megalencephaly (HP:0001355)1.94227393
97Postaxial hand polydactyly (HP:0001162)1.94069976
98Renal hypoplasia (HP:0000089)1.93879383
99Abnormality of chromosome stability (HP:0003220)1.93775210
100Hemoptysis (HP:0002105)1.93698649
101Recurrent gram-negative bacterial infections (HP:0005420)1.93129889
102Deviation of the thumb (HP:0009603)1.92849812
103Gastrointestinal infarctions (HP:0005244)1.92099884
104Autoimmune thrombocytopenia (HP:0001973)1.91691020
105Aplasia/Hypoplasia of the tibia (HP:0005772)1.91543389
106Small hand (HP:0200055)1.90774551
107Gastrointestinal atresia (HP:0002589)1.89211422
108Absent septum pellucidum (HP:0001331)1.88960693
109Large earlobe (HP:0009748)1.88335105
110Myelodysplasia (HP:0002863)1.87153842
111Absent frontal sinuses (HP:0002688)1.86727866
112Genetic anticipation (HP:0003743)1.86535964
113Proximal placement of thumb (HP:0009623)1.86108541
114Aseptic necrosis (HP:0010885)1.85782626
115Aplasia/Hypoplasia of the tongue (HP:0010295)1.84736429
116Hyperventilation (HP:0002883)1.84008497
117Acute myeloid leukemia (HP:0004808)1.83927388
118Neoplasm of the adrenal cortex (HP:0100641)1.83331914
119Nephrogenic diabetes insipidus (HP:0009806)1.83222298
120Short tibia (HP:0005736)1.82852786
121Abnormality of T cells (HP:0002843)1.82808367
122Absent radius (HP:0003974)1.82348899
123Reticulocytopenia (HP:0001896)1.82181532
124Peritonitis (HP:0002586)1.81806129
125Lymphoma (HP:0002665)1.81572145
126Fair hair (HP:0002286)1.81557794
127Sloping forehead (HP:0000340)1.80235284
128Abnormality of the prostate (HP:0008775)1.78965157
129Abnormality of the antihelix (HP:0009738)1.78729639
130Pustule (HP:0200039)1.78028504
131Broad-based gait (HP:0002136)1.77983667
132Chest pain (HP:0100749)1.77257264
133Abnormality of the labia minora (HP:0012880)1.76251293
134Abnormality of the pleura (HP:0002103)1.75981555
135Thyroiditis (HP:0100646)1.75591587
136Hepatoblastoma (HP:0002884)1.75487599
137Bilateral microphthalmos (HP:0007633)1.75435272
138Systemic lupus erythematosus (HP:0002725)1.74916686
139Thick nail (HP:0001805)1.74373385
140Breast hypoplasia (HP:0003187)1.73685768
141Embryonal renal neoplasm (HP:0011794)1.73255125
142Rhabdomyosarcoma (HP:0002859)1.73117812
143Mesomelia (HP:0003027)1.72752767
144Broad foot (HP:0001769)1.71870074
145Anencephaly (HP:0002323)1.71820276
146IgM deficiency (HP:0002850)1.71380067
147Astigmatism (HP:0000483)1.70747814
148Anorexia (HP:0002039)1.69892037
149Inappropriate behavior (HP:0000719)1.69526395
150Basal ganglia calcification (HP:0002135)1.69479014
151Eosinophilia (HP:0001880)1.69270867
152Abnormality of the pons (HP:0007361)1.69069048
153Hypochromic microcytic anemia (HP:0004840)1.68844440
154Medulloblastoma (HP:0002885)1.67677389
155Malignant gastrointestinal tract tumors (HP:0006749)1.67642242
156Gastrointestinal carcinoma (HP:0002672)1.67642242
157Abnormality of the fingertips (HP:0001211)1.67197604
158Abnormality of salivation (HP:0100755)1.66633691
159Aplasia involving forearm bones (HP:0009822)1.66122709
160Absent forearm bone (HP:0003953)1.66122709
161Aqueductal stenosis (HP:0002410)1.66073964
162Stenosis of the external auditory canal (HP:0000402)1.65791200
163Median cleft lip (HP:0000161)1.65569918
164Glomerulopathy (HP:0100820)1.65300537
165Amyotrophic lateral sclerosis (HP:0007354)1.64873125
166Neoplasm of striated muscle (HP:0009728)1.64660203
167Thyroid carcinoma (HP:0002890)1.64580009
168Widely spaced teeth (HP:0000687)1.64285884
169Premature loss of primary teeth (HP:0006323)1.64180318
170Progressive inability to walk (HP:0002505)1.63502137
171Blepharitis (HP:0000498)1.63267981
172Increased cerebral lipofuscin (HP:0011813)1.63187749
173Meckel diverticulum (HP:0002245)1.63000777
174Gangrene (HP:0100758)1.62898915
175Astrocytoma (HP:0009592)1.62879329
176Abnormality of the astrocytes (HP:0100707)1.62879329
177Abnormality of aspartate family amino acid metabolism (HP:0010899)1.62170836
178Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61733089
179Nephroblastoma (Wilms tumor) (HP:0002667)1.61627442
180Abnormality of the anterior horn cell (HP:0006802)1.61404633
181Degeneration of anterior horn cells (HP:0002398)1.61404633
182Sclerocornea (HP:0000647)1.60891425
183Duplicated collecting system (HP:0000081)1.59777739
184Spinal muscular atrophy (HP:0007269)1.58948835
185Abnormality of the nasal septum (HP:0000419)1.58946421
186Aplasia/Hypoplasia of the uvula (HP:0010293)1.58381926
187Neoplasm of the oral cavity (HP:0100649)1.57812509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.48563448
2WNK33.19895222
3TXK2.82507345
4JAK32.59752651
5MAP3K142.51090928
6PNCK2.49661499
7MAP4K12.44214675
8NUAK12.41063948
9TNIK2.31827378
10MARK12.26993947
11MAPK132.26480873
12CDC72.22486382
13CASK2.07472229
14EIF2AK32.05525692
15STK102.00708870
16NEK22.00664501
17IRAK31.96654431
18FRK1.92748591
19WEE11.91580209
20BMPR1B1.85527649
21EPHA21.82532742
22TYK21.79932106
23IKBKB1.74471164
24DYRK21.74421197
25IRAK41.73421739
26BRD41.69267680
27BLK1.68903469
28BCR1.64273742
29TAF11.59269640
30RPS6KA41.57427902
31ZAP701.56745303
32CDK61.53752463
33CLK11.52917084
34EEF2K1.47655038
35TTK1.47534040
36PIM11.45066886
37CDK191.44990625
38CHUK1.41582518
39BRSK21.40756792
40TESK21.35803564
41TRIM281.33079888
42CDK41.30604154
43TTN1.30204367
44MAP4K21.29523349
45BUB11.29000969
46TBK11.28704511
47NEK91.28570391
48ADRBK21.28439446
49STK161.26892388
50BMX1.25689062
51STK41.24798650
52TEC1.24751159
53NME21.24208758
54TSSK61.23962713
55STK38L1.23716006
56MAP3K81.21445223
57MST41.20233628
58SCYL21.20197174
59ATR1.19676717
60ALK1.17646363
61MAP3K41.16741260
62PBK1.15647199
63CCNB11.14994360
64EPHB11.14247969
65VRK11.13679312
66STK31.13308982
67PAK31.12130373
68PIM21.11194781
69ERBB31.11179314
70CSK1.11108389
71CDK71.08566804
72HCK1.07776831
73ITK1.06516407
74PLK41.06330031
75TLK11.05630918
76PAK41.05244567
77JAK11.02817732
78PKN11.02411192
79SRPK11.01736362
80OXSR11.00867716
81PLK11.00654093
82CAMK1D0.99065680
83LCK0.98635042
84RPS6KB20.98471999
85FGFR10.98148628
86IKBKE0.96470121
87PLK30.95972552
88PKN20.95034904
89MKNK10.94032398
90GRK10.93378195
91KIT0.90991082
92PLK20.90970310
93LRRK20.90214523
94AURKB0.88921035
95BTK0.88757756
96CHEK10.85737385
97FGFR20.85441556
98EPHA30.81602120
99CDK30.80549381
100EIF2AK10.78407887
101ZAK0.77156905
102MTOR0.76014010
103FGFR30.74979552
104PRKCE0.73540950
105NLK0.73269842
106MELK0.73203082
107NTRK20.72641291
108PASK0.72503532
109ATM0.72450893
110EPHA40.71857560
111CHEK20.71558364
112MAP3K100.71132997
113CSF1R0.68196627
114CDK90.64429385
115PTK60.63319325
116YES10.63243509
117MARK30.63175381
118FLT30.63018240
119JAK20.62888311
120RPS6KA50.61614233
121CDK20.60316528
122EGFR0.59401547
123PRKCG0.58684062
124FGR0.58380357
125INSRR0.57532886
126MKNK20.57513861
127ACVR1B0.54341847
128NEK10.52593694
129MAP2K30.52537421
130TGFBR10.52493289
131ABL10.52304512
132EIF2AK20.52298495
133PAK20.52255877
134UHMK10.52162739
135FGFR40.51080526
136CSNK1G10.50979276
137CSNK1G20.50443387
138LYN0.50285807
139MINK10.50177931
140DYRK30.49827551
141IRAK10.48577687
142PAK10.47880654
143MAPKAPK20.46870514
144LATS10.46780323
145TRPM70.46756120
146STK390.46626606
147DYRK1A0.45082227
148GRK70.44390293
149SGK20.43705658
150CAMK1G0.43328871
151MAP2K70.42955084
152CAMKK20.42116649
153TGFBR20.41929833
154PRKDC0.41015721
155STK240.40978618
156IGF1R0.38827902
157VRK20.38100208
158ERBB20.35930815
159TAOK30.35606652
160WNK10.35127467
161IRAK20.33585377
162PRKCQ0.32222655
163CSNK1A1L0.31525929
164NME10.31232705

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.37951945
2Allograft rejection_Homo sapiens_hsa053302.26414418
3Leishmaniasis_Homo sapiens_hsa051402.19904153
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19039470
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.19001298
6DNA replication_Homo sapiens_hsa030302.14003323
7Graft-versus-host disease_Homo sapiens_hsa053321.98989425
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97827365
9Propanoate metabolism_Homo sapiens_hsa006401.95814401
10Mismatch repair_Homo sapiens_hsa034301.93647681
11Nicotine addiction_Homo sapiens_hsa050331.86577293
12Measles_Homo sapiens_hsa051621.84777417
13One carbon pool by folate_Homo sapiens_hsa006701.83627186
14Phototransduction_Homo sapiens_hsa047441.81195416
15Legionellosis_Homo sapiens_hsa051341.75426370
16RNA transport_Homo sapiens_hsa030131.72478622
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69422856
18Asthma_Homo sapiens_hsa053101.66206787
19Antigen processing and presentation_Homo sapiens_hsa046121.64868129
20Cell cycle_Homo sapiens_hsa041101.60742932
21Spliceosome_Homo sapiens_hsa030401.59742818
22Osteoclast differentiation_Homo sapiens_hsa043801.59454444
23Steroid biosynthesis_Homo sapiens_hsa001001.59100327
24Herpes simplex infection_Homo sapiens_hsa051681.57886893
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.56689511
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53276059
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52756994
28p53 signaling pathway_Homo sapiens_hsa041151.49620304
29Autoimmune thyroid disease_Homo sapiens_hsa053201.48059934
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43551311
31Malaria_Homo sapiens_hsa051441.40982817
32Staphylococcus aureus infection_Homo sapiens_hsa051501.40019948
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.38918451
34Hedgehog signaling pathway_Homo sapiens_hsa043401.38742642
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37330954
36TNF signaling pathway_Homo sapiens_hsa046681.35770664
37Viral myocarditis_Homo sapiens_hsa054161.35764776
38Selenocompound metabolism_Homo sapiens_hsa004501.34450087
39Toxoplasmosis_Homo sapiens_hsa051451.34313458
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33926579
41Base excision repair_Homo sapiens_hsa034101.33670271
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31509588
43T cell receptor signaling pathway_Homo sapiens_hsa046601.31215212
44Homologous recombination_Homo sapiens_hsa034401.30235648
45Apoptosis_Homo sapiens_hsa042101.29854810
46Pertussis_Homo sapiens_hsa051331.28525726
47Influenza A_Homo sapiens_hsa051641.27552050
48Primary immunodeficiency_Homo sapiens_hsa053401.26619473
49* Viral carcinogenesis_Homo sapiens_hsa052031.26276600
50* Epstein-Barr virus infection_Homo sapiens_hsa051691.25393997
51Fanconi anemia pathway_Homo sapiens_hsa034601.25357458
52Tuberculosis_Homo sapiens_hsa051521.23309582
53Hematopoietic cell lineage_Homo sapiens_hsa046401.23029110
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21638637
55Type I diabetes mellitus_Homo sapiens_hsa049401.19747992
56Shigellosis_Homo sapiens_hsa051311.19412147
57MicroRNAs in cancer_Homo sapiens_hsa052061.19096614
58Oocyte meiosis_Homo sapiens_hsa041141.18521979
59Oxidative phosphorylation_Homo sapiens_hsa001901.16913562
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16729652
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16703206
62Small cell lung cancer_Homo sapiens_hsa052221.16567988
63Chronic myeloid leukemia_Homo sapiens_hsa052201.14614847
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12315381
65Nucleotide excision repair_Homo sapiens_hsa034201.11216077
66Hepatitis B_Homo sapiens_hsa051611.10829100
67HTLV-I infection_Homo sapiens_hsa051661.09786348
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09541914
69Wnt signaling pathway_Homo sapiens_hsa043101.08420351
70Parkinsons disease_Homo sapiens_hsa050121.08070180
71Non-homologous end-joining_Homo sapiens_hsa034501.07376118
72B cell receptor signaling pathway_Homo sapiens_hsa046621.07196652
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05768332
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05567312
75Regulation of autophagy_Homo sapiens_hsa041401.04545144
76Systemic lupus erythematosus_Homo sapiens_hsa053221.01964658
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00491938
78Basal cell carcinoma_Homo sapiens_hsa052171.00238372
79Salmonella infection_Homo sapiens_hsa051321.00063035
80Rheumatoid arthritis_Homo sapiens_hsa053230.99367287
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99127104
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97977790
83RNA polymerase_Homo sapiens_hsa030200.97523794
84mRNA surveillance pathway_Homo sapiens_hsa030150.93154456
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92734088
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92563958
87Glutamatergic synapse_Homo sapiens_hsa047240.91259184
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89603036
89Acute myeloid leukemia_Homo sapiens_hsa052210.89258609
90Chemokine signaling pathway_Homo sapiens_hsa040620.88783211
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.88336019
92Dorso-ventral axis formation_Homo sapiens_hsa043200.87659419
93Ribosome_Homo sapiens_hsa030100.85774482
94Taste transduction_Homo sapiens_hsa047420.82879263
95RNA degradation_Homo sapiens_hsa030180.82313221
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81725469
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81195317
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80618588
99Ether lipid metabolism_Homo sapiens_hsa005650.79803162
100Huntingtons disease_Homo sapiens_hsa050160.79697793
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79604726
102Pancreatic cancer_Homo sapiens_hsa052120.79247802
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.78286141
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76118127
105HIF-1 signaling pathway_Homo sapiens_hsa040660.75963173
106Adherens junction_Homo sapiens_hsa045200.75136102
107Purine metabolism_Homo sapiens_hsa002300.75121086
108Proteoglycans in cancer_Homo sapiens_hsa052050.74481772
109Axon guidance_Homo sapiens_hsa043600.73035014
110Proteasome_Homo sapiens_hsa030500.71910007
111Linoleic acid metabolism_Homo sapiens_hsa005910.71880146
112Morphine addiction_Homo sapiens_hsa050320.71642145
113Phagosome_Homo sapiens_hsa041450.71137964
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70447811
115Hippo signaling pathway_Homo sapiens_hsa043900.70265913
116Long-term depression_Homo sapiens_hsa047300.69606554
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69556288
118Olfactory transduction_Homo sapiens_hsa047400.67551741
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64747521
120Amoebiasis_Homo sapiens_hsa051460.63258925
121* Notch signaling pathway_Homo sapiens_hsa043300.63107055
122Colorectal cancer_Homo sapiens_hsa052100.62388697
123Hepatitis C_Homo sapiens_hsa051600.62324350
124Lysosome_Homo sapiens_hsa041420.62205905
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61766649
126Pyrimidine metabolism_Homo sapiens_hsa002400.61608835
127TGF-beta signaling pathway_Homo sapiens_hsa043500.61476634
128Basal transcription factors_Homo sapiens_hsa030220.60572785
129Prolactin signaling pathway_Homo sapiens_hsa049170.59133498
130Circadian entrainment_Homo sapiens_hsa047130.58378219
131Prostate cancer_Homo sapiens_hsa052150.58092685
132Melanoma_Homo sapiens_hsa052180.57582836
133Other glycan degradation_Homo sapiens_hsa005110.53879260
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.53390613
135Pathways in cancer_Homo sapiens_hsa052000.53058451
136Circadian rhythm_Homo sapiens_hsa047100.52961440
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.52021545
138mTOR signaling pathway_Homo sapiens_hsa041500.52007219
139Dopaminergic synapse_Homo sapiens_hsa047280.51608809
140Renal cell carcinoma_Homo sapiens_hsa052110.51587485
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51286231
142Alzheimers disease_Homo sapiens_hsa050100.50016616
143Serotonergic synapse_Homo sapiens_hsa047260.48276440
144African trypanosomiasis_Homo sapiens_hsa051430.47095442
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45980447
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45764309
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44771669
148Focal adhesion_Homo sapiens_hsa045100.43782135
149GABAergic synapse_Homo sapiens_hsa047270.41823630
150Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41468867
151Ras signaling pathway_Homo sapiens_hsa040140.40815416
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38843739
153Lysine degradation_Homo sapiens_hsa003100.37707410
154Nitrogen metabolism_Homo sapiens_hsa009100.36062191
155Cocaine addiction_Homo sapiens_hsa050300.35565565
156Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35332769
157Amphetamine addiction_Homo sapiens_hsa050310.32869217
158Gap junction_Homo sapiens_hsa045400.29407567
159Collecting duct acid secretion_Homo sapiens_hsa049660.26948790
160Primary bile acid biosynthesis_Homo sapiens_hsa001200.26004192

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