RBPJL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the suppressor of hairless protein family. A similar protein in mouse is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signaling pathway transcription factor recombining binding protein J. The mouse protein has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cobalamin metabolic process (GO:0009235)8.85329367
2negative regulation of epidermis development (GO:0045683)8.25813372
3phosphatidylinositol acyl-chain remodeling (GO:0036149)8.08891707
4phosphatidylserine acyl-chain remodeling (GO:0036150)7.88005447
5phosphatidylglycerol acyl-chain remodeling (GO:0036148)7.65835009
6transcytosis (GO:0045056)7.46416922
7peptidyl-proline hydroxylation (GO:0019511)7.31943174
8sterol catabolic process (GO:0016127)7.27079733
9cholesterol catabolic process (GO:0006707)7.27079733
10intestinal absorption (GO:0050892)6.88465117
11myeloid leukocyte mediated immunity (GO:0002444)6.80960620
12icosanoid transport (GO:0071715)6.71446875
13fatty acid derivative transport (GO:1901571)6.71446875
14regulation of phospholipase A2 activity (GO:0032429)6.40233326
15cysteine metabolic process (GO:0006534)6.39296745
16regulation of keratinocyte differentiation (GO:0045616)6.31667281
17negative regulation of digestive system process (GO:0060457)6.01104596
18atrioventricular valve morphogenesis (GO:0003181)5.93733549
19proline biosynthetic process (GO:0006561)5.87281576
20innate immune response in mucosa (GO:0002227)5.86133470
21glycolipid catabolic process (GO:0019377)5.84664283
22regulation of keratinocyte proliferation (GO:0010837)5.80983334
23membrane lipid catabolic process (GO:0046466)5.76048550
24protein hydroxylation (GO:0018126)5.73989160
25phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.64638597
26regulation of cholesterol homeostasis (GO:2000188)5.58013540
27COPI coating of Golgi vesicle (GO:0048205)5.52870180
28Golgi transport vesicle coating (GO:0048200)5.52870180
29branched-chain amino acid catabolic process (GO:0009083)5.24937572
30ceramide catabolic process (GO:0046514)5.17199886
31mitochondrial calcium ion transport (GO:0006851)5.16832609
32regulation of bile acid biosynthetic process (GO:0070857)5.07547380
33intestinal epithelial cell development (GO:0060576)5.06677392
34negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)5.03706434
35mucosal immune response (GO:0002385)4.85271064
36activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.84058167
37valine metabolic process (GO:0006573)4.75853554
38phosphatidylcholine acyl-chain remodeling (GO:0036151)4.73655083
39serine family amino acid biosynthetic process (GO:0009070)4.65673223
40positive regulation of nuclease activity (GO:0032075)4.63546098
41zinc ion transport (GO:0006829)4.62263467
42cellular modified amino acid catabolic process (GO:0042219)4.61691059
43phosphatidic acid metabolic process (GO:0046473)4.58952969
44phosphatidic acid biosynthetic process (GO:0006654)4.58952969
45phosphatidylserine metabolic process (GO:0006658)4.57242737
46branched-chain amino acid metabolic process (GO:0009081)4.49801078
47response to endoplasmic reticulum stress (GO:0034976)4.45776876
48mitochondrion distribution (GO:0048311)4.41224395
49organ or tissue specific immune response (GO:0002251)4.39157646
50endoplasmic reticulum unfolded protein response (GO:0030968)4.36746046
51positive regulation of heat generation (GO:0031652)4.36153750
52cellular response to unfolded protein (GO:0034620)4.22809633
53homocysteine metabolic process (GO:0050667)4.21251651
54regulation of nuclease activity (GO:0032069)4.21103535
55regulation of fever generation (GO:0031620)4.18739429
56antimicrobial humoral response (GO:0019730)4.18693548
57aspartate family amino acid catabolic process (GO:0009068)4.10883141
58leukotriene biosynthetic process (GO:0019370)4.10287513
59polarized epithelial cell differentiation (GO:0030859)4.07379762
60piRNA metabolic process (GO:0034587)4.04844042
61ER-nucleus signaling pathway (GO:0006984)4.03427739
62L-serine metabolic process (GO:0006563)3.99655713
63synaptonemal complex assembly (GO:0007130)3.98891957
64cellular response to topologically incorrect protein (GO:0035967)3.97857349
65maintenance of protein localization in organelle (GO:0072595)3.96589033
66protein maturation by protein folding (GO:0022417)3.96484445
67positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.93866904
684-hydroxyproline metabolic process (GO:0019471)3.92553123
69defense response to Gram-positive bacterium (GO:0050830)3.90449261
70leukotriene metabolic process (GO:0006691)3.88175410
71proline metabolic process (GO:0006560)3.87129920
72phosphatidylglycerol metabolic process (GO:0046471)3.86006096
73male meiosis I (GO:0007141)3.83672607
74endocrine pancreas development (GO:0031018)3.79049238
75chemical homeostasis within a tissue (GO:0048875)3.78726864
76alditol phosphate metabolic process (GO:0052646)3.77311605
77glutamine metabolic process (GO:0006541)3.75966559
78water-soluble vitamin metabolic process (GO:0006767)3.73685436
79signal peptide processing (GO:0006465)3.69482120
80lung secretory cell differentiation (GO:0061140)3.68057403
81synapsis (GO:0007129)3.67569586
82chromosome organization involved in meiosis (GO:0070192)3.62194653
83regulation of epidermal cell differentiation (GO:0045604)3.60639213
84negative regulation of epithelial cell differentiation (GO:0030857)3.60070258
85cellular protein catabolic process (GO:0044257)3.59107565
86synaptonemal complex organization (GO:0070193)3.56497875
87steroid catabolic process (GO:0006706)3.55083023
88epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.54924621
89endothelial cell migration (GO:0043542)3.51539922
90neutrophil mediated immunity (GO:0002446)3.51026635
91serine family amino acid metabolic process (GO:0009069)3.47414317
92histone H3-K9 demethylation (GO:0033169)3.46273812
93ER overload response (GO:0006983)3.43062650
94establishment of apical/basal cell polarity (GO:0035089)3.42715030
95coenzyme catabolic process (GO:0009109)3.42228826
96response to unfolded protein (GO:0006986)3.41994793
97COPII vesicle coating (GO:0048208)3.41746367
98creatine metabolic process (GO:0006600)3.41323527
99defense response to Gram-negative bacterium (GO:0050829)3.40872382
100endocardial cushion morphogenesis (GO:0003203)3.39495404
101regulation of heat generation (GO:0031650)3.37763249
102ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.32233002
103negative regulation of epidermal cell differentiation (GO:0045605)3.31965872
104surfactant homeostasis (GO:0043129)3.31960649
105sphingolipid catabolic process (GO:0030149)3.31380240
106negative regulation of cell fate commitment (GO:0010454)3.26628890
107response to topologically incorrect protein (GO:0035966)3.26013141
108retinoic acid receptor signaling pathway (GO:0048384)3.17144151
109protein N-linked glycosylation via asparagine (GO:0018279)3.15833753
110peptidyl-asparagine modification (GO:0018196)3.14752527
111erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.13864163
112L-phenylalanine catabolic process (GO:0006559)3.13864163
113icosanoid biosynthetic process (GO:0046456)3.13314302
114fatty acid derivative biosynthetic process (GO:1901570)3.13314302
115retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.10762249
116digestive system process (GO:0022600)3.10138535
117pancreas development (GO:0031016)3.09904433
118antibacterial humoral response (GO:0019731)3.09731220
119regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.08498682
120arachidonic acid secretion (GO:0050482)3.07768987
121icosanoid secretion (GO:0032309)3.07768987
122regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)3.07655232
123GDP-mannose metabolic process (GO:0019673)3.03831985
124activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.02893502
125regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.99720237
126positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.99720237
127male meiosis (GO:0007140)2.99695293
128retina layer formation (GO:0010842)2.98961930
129multicellular organismal catabolic process (GO:0044243)2.98835943
130L-phenylalanine metabolic process (GO:0006558)2.98670106
131erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.98670106
132glomerulus development (GO:0032835)2.96650198
133regulation of oxidative stress-induced cell death (GO:1903201)2.96182486
134cell redox homeostasis (GO:0045454)2.95708928
135peptide catabolic process (GO:0043171)2.94646279
136DNA methylation involved in gamete generation (GO:0043046)2.91934090
137tetrapyrrole metabolic process (GO:0033013)2.90444448
138phospholipid catabolic process (GO:0009395)2.89825493
139protein N-linked glycosylation (GO:0006487)2.88969827
140establishment of monopolar cell polarity (GO:0061162)2.88877325
141establishment or maintenance of monopolar cell polarity (GO:0061339)2.88877325
142sulfur amino acid biosynthetic process (GO:0000097)2.88410846
143glycine transport (GO:0015816)2.88378379
144sterol transport (GO:0015918)2.85845391
145cholesterol transport (GO:0030301)2.85845391
146meiosis I (GO:0007127)2.85077355
147long-chain fatty acid transport (GO:0015909)2.82554356
148DNA synthesis involved in DNA repair (GO:0000731)2.82465311
149positive regulation of calcium ion transport into cytosol (GO:0010524)2.81911522
150vitamin metabolic process (GO:0006766)2.79726899
151mesenchyme morphogenesis (GO:0072132)2.79630563
152positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.78995773
153regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.78995773
154acute-phase response (GO:0006953)2.73049907
155meiotic nuclear division (GO:0007126)2.70318142
156response to leptin (GO:0044321)2.63532224
157negative regulation of receptor activity (GO:2000272)2.63117970
158epithelial cell migration (GO:0010631)2.58025630
159multicellular organismal metabolic process (GO:0044236)2.55799210
160positive regulation of wound healing (GO:0090303)2.54297886
161positive regulation of fibroblast proliferation (GO:0048146)2.53607193
162positive regulation of guanylate cyclase activity (GO:0031284)2.51876842
163negative regulation of androgen receptor signaling pathway (GO:0060766)2.51288009
164L-alpha-amino acid transmembrane transport (GO:1902475)2.50895133
165unsaturated fatty acid biosynthetic process (GO:0006636)2.48024734
166exocrine pancreas development (GO:0031017)16.7524059
167intestinal cholesterol absorption (GO:0030299)16.4499825
168digestion (GO:0007586)13.4930411
169protein retention in ER lumen (GO:0006621)11.9625790
170maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.1881999

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.80187478
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.67082828
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.80679098
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.85199531
5GATA4_25053715_ChIP-Seq_YYC3_Human2.83023012
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.65143409
7GATA1_26923725_Chip-Seq_HPCs_Mouse2.62843215
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.62199014
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.53130813
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.40015095
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.38413019
12* ERG_21242973_ChIP-ChIP_JURKAT_Human2.35948515
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29368824
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.28622682
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.27889332
16GATA6_25053715_ChIP-Seq_YYC3_Human2.27070381
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.14380484
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01562348
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.01106842
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.01106842
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.01106842
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.00505866
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.96845446
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92572824
25PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.92012865
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90141899
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.89351183
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.85569860
29GATA1_22025678_ChIP-Seq_K562_Human1.85416393
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59152035
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58999233
32PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.58690844
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57344493
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51454010
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51326515
36CLOCK_20551151_ChIP-Seq_293T_Human1.49370691
37CREB1_26743006_Chip-Seq_LNCaP_Human1.48951485
38ETV1_20927104_ChIP-Seq_GIST48_Human1.48007812
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46503755
40P63_26484246_Chip-Seq_KERATINOCYTES_Human1.45800907
41CHD1_26751641_Chip-Seq_LNCaP_Human1.44906324
42LXR_22292898_ChIP-Seq_THP-1_Human1.43699600
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.43448425
44PHF8_20622853_ChIP-Seq_HELA_Human1.42676503
45RUNX1_27514584_Chip-Seq_MCF-7_Human1.42572384
46SOX2_20726797_ChIP-Seq_SW620_Human1.41587066
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.40176899
48FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.39726252
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35694616
50HNFA_21074721_ChIP-Seq_CACO-2_Human1.33460340
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32897309
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32117776
53CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.29051732
54RACK7_27058665_Chip-Seq_MCF-7_Human1.28733192
55RBPJ_21746931_ChIP-Seq_IB4_Human1.27492880
56FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.25179876
57NFYA_21822215_ChIP-Seq_K562_Human1.24967684
58CBX2_22325352_ChIP-Seq_293T-Rex_Human1.20823583
59PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.20595131
60P68_20966046_ChIP-Seq_HELA_Human1.19855254
61GATA6_21074721_ChIP-Seq_CACO-2_Human1.17915515
62ATF3_27146783_Chip-Seq_COLON_Human1.17193867
63GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.16863286
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16774777
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.16291166
66BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15395261
67AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13404891
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13379315
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13230638
70NFYB_21822215_ChIP-Seq_K562_Human1.11881397
71TP63_22573176_ChIP-Seq_HFKS_Human1.11329181
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10528333
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.10319721
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.10319721
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10026084
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09149658
77EGR1_19032775_ChIP-ChIP_M12_Human1.08529970
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.07916737
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.07279012
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06639253
81EZH2_22144423_ChIP-Seq_EOC_Human1.05992854
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05483413
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05480541
84* ESET_19884257_ChIP-Seq_ESCs_Mouse1.02386750
85ERA_21632823_ChIP-Seq_H3396_Human0.99663633
86NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99273995
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97083156
88FOXA1_25552417_ChIP-Seq_VCAP_Human0.96425444
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96125912
90CTCF_27219007_Chip-Seq_Bcells_Human0.95613504
91GATA3_24758297_ChIP-Seq_MCF-7_Human0.95564749
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94965923
93* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93966275
94DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93431624
95ETS1_21867929_ChIP-Seq_TH2_Mouse0.93288511
96HTT_18923047_ChIP-ChIP_STHdh_Human0.92864936
97TBL1_22424771_ChIP-Seq_293T_Human0.90808814
98FOXH1_21741376_ChIP-Seq_ESCs_Human0.90724545
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89846847
100KLF5_25053715_ChIP-Seq_YYC3_Human0.89722022
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89249822
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88977364
103* KDM2B_26808549_Chip-Seq_K562_Human0.88094824
104SA1_27219007_Chip-Seq_Bcells_Human0.87467372
105ERG_20517297_ChIP-Seq_VCAP_Human0.86783119
106FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86334825
107GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86263932
108ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86258792
109OCT4_20526341_ChIP-Seq_ESCs_Human0.86060828
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85873031
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83920267
112AR_21572438_ChIP-Seq_LNCaP_Human0.83336851
113CEBPB_22108803_ChIP-Seq_LS180_Human0.82663633
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81033393
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80952729
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80299000
117TRIM28_21343339_ChIP-Seq_HEK293_Human0.80243478
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79454601
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78827086
120P53_22127205_ChIP-Seq_FIBROBLAST_Human0.77971831
121BCOR_27268052_Chip-Seq_Bcells_Human0.77369956
122P53_21459846_ChIP-Seq_SAOS-2_Human0.77300071
123KLF4_19829295_ChIP-Seq_ESCs_Human0.77196400
124EGR1_19374776_ChIP-ChIP_THP-1_Human0.75831778
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.75228938
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73135585
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.72666383
128RUNX1_26923725_Chip-Seq_HPCs_Mouse0.72351652
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.72335521
130LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.70451577
131SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.69913474
132NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.66306725
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.63989925
134MYC_19829295_ChIP-Seq_ESCs_Human0.62612062
135* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.60870439
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.59975783
137FLI1_21867929_ChIP-Seq_CD8_Mouse0.57987467
138CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.57472353
139EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.56326173
140* SOX2_21211035_ChIP-Seq_LN229_Human0.55506106
141GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.55480564
142RNF2_27304074_Chip-Seq_NSC_Mouse0.54565744
143SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.51350943
144OCT4_19829295_ChIP-Seq_ESCs_Human0.49643825
145MYC_19079543_ChIP-ChIP_MESCs_Mouse0.49388061
146P300_27268052_Chip-Seq_Bcells_Human0.49336742
147GF1_26923725_Chip-Seq_HPCs_Mouse0.48950186
148CDX2_22108803_ChIP-Seq_LS180_Human0.48664977
149EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.47534815
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.47275631
151VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.46469641
152LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.45885699
153* DPY_21335234_ChIP-Seq_ESCs_Mouse0.45604322
154FOXH1_21741376_ChIP-Seq_EPCs_Human0.45520844
155CTNNB1_20460455_ChIP-Seq_HCT116_Human0.45344999
156* SMAD4_21741376_ChIP-Seq_EPCs_Human0.45219359
157PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44423597
158STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.44027788

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption8.73898529
2MP0005220_abnormal_exocrine_pancreas6.43680515
3MP0005365_abnormal_bile_salt5.95631614
4MP0003868_abnormal_feces_composition4.85409700
5MP0005084_abnormal_gallbladder_morpholo4.77412122
6MP0005085_abnormal_gallbladder_physiolo3.40716145
7MP0001664_abnormal_digestion2.71850511
8MP0003959_abnormal_lean_body2.41905627
9MP0002693_abnormal_pancreas_physiology2.22138205
10MP0003705_abnormal_hypodermis_morpholog2.15827342
11MP0005083_abnormal_biliary_tract10.5054149
12MP0008004_abnormal_stomach_pH1.93794749
13MP0004782_abnormal_surfactant_physiolog1.81399970
14MP0004264_abnormal_extraembryonic_tissu1.79609132
15MP0008877_abnormal_DNA_methylation1.73529007
16MP0001501_abnormal_sleep_pattern1.69654196
17MP0001944_abnormal_pancreas_morphology1.66103550
18MP0001502_abnormal_circadian_rhythm1.64532930
19MP0004233_abnormal_muscle_weight1.56050515
20MP0010234_abnormal_vibrissa_follicle1.54649931
21MP0002277_abnormal_respiratory_mucosa1.45019524
22MP0005448_abnormal_energy_balance1.39152777
23MP0003638_abnormal_response/metabolism_1.37185227
24MP0008438_abnormal_cutaneous_collagen1.36162301
25MP0002139_abnormal_hepatobiliary_system1.28731423
26MP0005451_abnormal_body_composition1.26329685
27MP0002118_abnormal_lipid_homeostasis1.25854525
28MP0000470_abnormal_stomach_morphology1.19552767
29MP0003183_abnormal_peptide_metabolism1.18483989
30MP0003943_abnormal_hepatobiliary_system1.15769643
31MP0003122_maternal_imprinting1.09697815
32MP0005408_hypopigmentation1.07556393
33MP0006054_spinal_hemorrhage1.06052238
34MP0009384_cardiac_valve_regurgitation1.05474024
35MP0005332_abnormal_amino_acid0.97962184
36MP0000490_abnormal_crypts_of0.96366855
37MP0002970_abnormal_white_adipose0.95970820
38MP0002210_abnormal_sex_determination0.91713149
39MP0001873_stomach_inflammation0.90933072
40MP0003283_abnormal_digestive_organ0.90605936
41MP0005165_increased_susceptibility_to0.90345016
42MP0003828_pulmonary_edema0.89714471
43MP0005076_abnormal_cell_differentiation0.89543934
44MP0010368_abnormal_lymphatic_system0.87778877
45MP0000003_abnormal_adipose_tissue0.87722051
46MP0003123_paternal_imprinting0.87500914
47MP0001145_abnormal_male_reproductive0.83736673
48MP0000566_synostosis0.79176513
49MP0000653_abnormal_sex_gland0.78413230
50MP0003045_fibrosis0.76230200
51MP0002098_abnormal_vibrissa_morphology0.75611883
52MP0002138_abnormal_hepatobiliary_system0.74918152
53MP0003195_calcinosis0.72333579
54MP0000678_abnormal_parathyroid_gland0.71064004
55MP0008789_abnormal_olfactory_epithelium0.69566360
56MP0003941_abnormal_skin_development0.68370722
57MP0001929_abnormal_gametogenesis0.68327068
58MP0010386_abnormal_urinary_bladder0.67967213
59MP0008961_abnormal_basal_metabolism0.67364756
60MP0000613_abnormal_salivary_gland0.66072030
61MP0008770_decreased_survivor_rate0.65027176
62MP0009643_abnormal_urine_homeostasis0.64935965
63MP0001958_emphysema0.64660794
64MP0003698_abnormal_male_reproductive0.64579945
65MP0002078_abnormal_glucose_homeostasis0.64489962
66MP0010678_abnormal_skin_adnexa0.63999175
67MP0003879_abnormal_hair_cell0.63932461
68MP0002132_abnormal_respiratory_system0.59784132
69MP0004272_abnormal_basement_membrane0.58211786
70MP0010329_abnormal_lipoprotein_level0.57586891
71MP0003252_abnormal_bile_duct0.56987098
72MP0002876_abnormal_thyroid_physiology0.56798080
73MP0001663_abnormal_digestive_system0.56317004
74MP0002796_impaired_skin_barrier0.56302659
75MP0002089_abnormal_postnatal_growth/wei0.55351297
76MP0004185_abnormal_adipocyte_glucose0.55287608
77MP0005381_digestive/alimentary_phenotyp0.53334758
78MP0003115_abnormal_respiratory_system0.53184424
79MP0002295_abnormal_pulmonary_circulatio0.52501028
80MP0005647_abnormal_sex_gland0.52358939
81MP0005058_abnormal_lysosome_morphology0.52318999
82MP0002163_abnormal_gland_morphology0.51557353
83MP0008058_abnormal_DNA_repair0.51118265
84MP0000432_abnormal_head_morphology0.50536252
85MP0000647_abnormal_sebaceous_gland0.50524837
86MP0003300_gastrointestinal_ulcer0.50388700
87MP0003953_abnormal_hormone_level0.50366013
88MP0002060_abnormal_skin_morphology0.49614156
89MP0004043_abnormal_pH_regulation0.48202352
90MP0010307_abnormal_tumor_latency0.47885163
91MP0002928_abnormal_bile_duct0.47680380
92MP0003806_abnormal_nucleotide_metabolis0.47601130
93MP0000537_abnormal_urethra_morphology0.47105762
94MP0009765_abnormal_xenobiotic_induced0.47099880
95MP0003119_abnormal_digestive_system0.46012318
96MP0005394_taste/olfaction_phenotype0.45596305
97MP0005499_abnormal_olfactory_system0.45596305
98MP0009703_decreased_birth_body0.44580990
99MP0002009_preneoplasia0.44337516
100MP0000377_abnormal_hair_follicle0.43645902
101MP0005377_hearing/vestibular/ear_phenot0.43413113
102MP0003878_abnormal_ear_physiology0.43413113
103MP0001119_abnormal_female_reproductive0.42448556
104MP0001177_atelectasis0.42406007
105MP0005375_adipose_tissue_phenotype0.42385490
106MP0005535_abnormal_body_temperature0.42306598
107MP0001731_abnormal_postnatal_growth0.42296951
108MP0005452_abnormal_adipose_tissue0.41996418
109MP0003942_abnormal_urinary_system0.40973130
110MP0000598_abnormal_liver_morphology0.40609785
111MP0003699_abnormal_female_reproductive0.40441111
112MP0005666_abnormal_adipose_tissue0.38174121
113MP0000750_abnormal_muscle_regeneration0.38089878
114MP0003795_abnormal_bone_structure0.37798704
115MP0000383_abnormal_hair_follicle0.36345515
116MP0002638_abnormal_pupillary_reflex0.35958416
117MP0003786_premature_aging0.34925740
118MP0001340_abnormal_eyelid_morphology0.34566129
119MP0002938_white_spotting0.33578222
120MP0000367_abnormal_coat/_hair0.33361392
121MP0008057_abnormal_DNA_replication0.32742493
122MP0003186_abnormal_redox_activity0.32569777
123MP0000534_abnormal_ureter_morphology0.32457794
124MP0000462_abnormal_digestive_system0.31269650
125MP0003329_amyloid_beta_deposits0.30852180
126MP0009672_abnormal_birth_weight0.30216713
127MP0004019_abnormal_vitamin_homeostasis0.29764141
128MP0006138_congestive_heart_failure0.29010840
129MP0001845_abnormal_inflammatory_respons0.28820811
130MP0005334_abnormal_fat_pad0.28327835
131MP0002161_abnormal_fertility/fecundity0.28246467
132MP0000371_diluted_coat_color0.27848379
133MP0002896_abnormal_bone_mineralization0.27616742
134MP0002168_other_aberrant_phenotype0.27487031
135MP0000762_abnormal_tongue_morphology0.27368075
136MP0000609_abnormal_liver_physiology0.26838557
137MP0008995_early_reproductive_senescence0.26105832
138MP0001784_abnormal_fluid_regulation0.25939731
139MP0000858_altered_metastatic_potential0.25812374
140MP0009333_abnormal_splenocyte_physiolog0.25733723
141MP0002108_abnormal_muscle_morphology0.25210438
142MP0002160_abnormal_reproductive_system0.25116615
143MP0002233_abnormal_nose_morphology0.24621455
144MP0005319_abnormal_enzyme/_coenzyme0.24526343
145MP0009780_abnormal_chondrocyte_physiolo0.24074501
146MP0000579_abnormal_nail_morphology0.23801222
147MP0002069_abnormal_eating/drinking_beha0.23773134
148MP0004134_abnormal_chest_morphology0.23192868
149MP0010352_gastrointestinal_tract_polyps0.22367928
150MP0003956_abnormal_body_size0.21226429
151MP0009642_abnormal_blood_homeostasis0.20958988
152MP0003567_abnormal_fetal_cardiomyocyte0.20899287
153MP0005670_abnormal_white_adipose0.20326188
154MP0002127_abnormal_cardiovascular_syste0.20029999
155MP0000631_abnormal_neuroendocrine_gland0.19933462
156MP0002971_abnormal_brown_adipose0.17789115

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)8.30769488
2Genetic anticipation (HP:0003743)7.21365662
3Fat malabsorption (HP:0002630)6.62581275
4Gout (HP:0001997)6.41066052
5Short chin (HP:0000331)5.92625784
6Decreased subcutaneous fat (HP:0001002)5.76808425
7Abnormality of subcutaneous fat tissue (HP:0001001)5.17389477
8Type I diabetes mellitus (HP:0100651)5.12934347
9Exocrine pancreatic insufficiency (HP:0001738)5.02452892
10Maternal diabetes (HP:0009800)4.51654807
11Progressive cerebellar ataxia (HP:0002073)4.49806295
12Hypoproteinemia (HP:0003075)4.39003425
13Tubulointerstitial fibrosis (HP:0005576)4.24957158
14Abnormality of the intrinsic pathway (HP:0010989)4.20052490
15Tubulointerstitial nephritis (HP:0001970)4.14992980
16Premature skin wrinkling (HP:0100678)3.98473581
17Joint stiffness (HP:0001387)3.94457016
18Hypoplasia of the pons (HP:0012110)3.81136111
19Abnormal pancreas size (HP:0012094)3.77050672
20Abnormality of the pons (HP:0007361)3.65036728
21Cortical dysplasia (HP:0002539)3.54886351
22Interstitial pulmonary disease (HP:0006530)3.53735912
23Epiphyseal dysplasia (HP:0002656)3.46807044
24Pancreatitis (HP:0001733)3.45551467
25Abnormality of the nasal septum (HP:0000419)3.42307640
26Small epiphyses (HP:0010585)3.40720113
27Carpal bone hypoplasia (HP:0001498)3.38319628
28Male infertility (HP:0003251)3.26991967
29Abnormal tarsal ossification (HP:0008369)3.20083082
30Abnormality of the pancreatic islet cells (HP:0006476)3.11166917
31Abnormality of endocrine pancreas physiology (HP:0012093)3.11166917
32Tubular atrophy (HP:0000092)3.10301619
33Abnormality of the fingertips (HP:0001211)3.06936529
34Abnormality of aromatic amino acid family metabolism (HP:0004338)3.04090779
35Ketosis (HP:0001946)3.01671989
36Anal atresia (HP:0002023)3.00041333
37Abnormality of the pleura (HP:0002103)2.98846977
38Ketoacidosis (HP:0001993)2.85857311
39Urethral obstruction (HP:0000796)2.84158854
40Increased purine levels (HP:0004368)2.81608676
41Hyperuricemia (HP:0002149)2.81608676
42Pigmentary retinal degeneration (HP:0001146)2.81007925
43Slow saccadic eye movements (HP:0000514)2.79331023
44Gonadotropin excess (HP:0000837)2.78202848
45Popliteal pterygium (HP:0009756)2.71049438
46Optic nerve hypoplasia (HP:0000609)2.68816910
47Preauricular pit (HP:0004467)2.64590610
48Periauricular skin pits (HP:0100277)2.64590610
49Renal salt wasting (HP:0000127)2.64458477
50Hypoplastic labia majora (HP:0000059)2.64113298
51Depressed nasal tip (HP:0000437)2.61394360
52Barrel-shaped chest (HP:0001552)2.60672177
53Flat acetabular roof (HP:0003180)2.58820107
54Abnormality of the common coagulation pathway (HP:0010990)2.56433460
55Pectus carinatum (HP:0000768)2.53183983
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.48242419
57Hypoplasia of the odontoid process (HP:0003311)2.47488765
58Long foot (HP:0001833)2.47460113
59Anal stenosis (HP:0002025)2.46610009
60Respiratory distress (HP:0002098)2.46541637
61Azoospermia (HP:0000027)2.44562224
62Papillary thyroid carcinoma (HP:0002895)2.43234588
63Abnormality of the labia majora (HP:0012881)2.42379002
64Prenatal maternal abnormality (HP:0002686)2.41670277
65Fatigue (HP:0012378)2.38758027
66Neonatal respiratory distress (HP:0002643)2.37522575
67Ankyloglossia (HP:0010296)2.37273648
68Abnormality of sulfur amino acid metabolism (HP:0004339)2.36841284
69Hypoplastic scapulae (HP:0000882)2.36110257
70Aplasia/Hypoplasia of the scapulae (HP:0006713)2.36110257
71Tubulointerstitial abnormality (HP:0001969)2.29354150
72Lip pit (HP:0100267)2.27702220
73Atrophic scars (HP:0001075)2.27696771
74Flattened epiphyses (HP:0003071)2.26319047
75Abnormal foot bone ossification (HP:0010675)2.25664560
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24610666
77Congenital glaucoma (HP:0001087)2.23887602
78Hyperglycinemia (HP:0002154)2.22673615
79Axonal loss (HP:0003447)2.21640029
80Hypotension (HP:0002615)2.21524756
81Abnormality of the columella (HP:0009929)2.20505398
82Chronic hepatic failure (HP:0100626)2.19304250
83Thoracic kyphosis (HP:0002942)2.17872040
84Absent eyelashes (HP:0000561)2.17336155
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.14667948
86Skin pits (HP:0100276)2.13792721
87Urinary bladder sphincter dysfunction (HP:0002839)2.12610452
88Abnormality of the aortic arch (HP:0012303)2.10291242
89Beaking of vertebral bodies (HP:0004568)2.08833081
90Hypoplastic iliac wings (HP:0002866)2.08117545
91Facial shape deformation (HP:0011334)2.06676794
92Potter facies (HP:0002009)2.06676794
93Type II lissencephaly (HP:0007260)2.04223003
94Volvulus (HP:0002580)2.01982015
95Tachypnea (HP:0002789)2.00353571
96Abnormality of the odontoid process (HP:0003310)2.00280940
97Abnormality of the lumbar spine (HP:0100712)1.99956028
98Absent eyebrow (HP:0002223)1.99418660
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98190119
100Abnormal protein N-linked glycosylation (HP:0012347)1.98190119
101Abnormal protein glycosylation (HP:0012346)1.98190119
102Abnormal glycosylation (HP:0012345)1.98190119
103Abnormality of chloride homeostasis (HP:0011422)1.94558979
104Esophageal varix (HP:0002040)1.94373319
105Abnormality of glycine metabolism (HP:0010895)1.92694666
106Abnormality of serine family amino acid metabolism (HP:0010894)1.92694666
107Abnormality of the thoracic spine (HP:0100711)1.91905199
108Portal hypertension (HP:0001409)1.91879728
109Insulin-resistant diabetes mellitus (HP:0000831)1.91768349
110Dysmetric saccades (HP:0000641)1.91676316
111Abnormality of the renal cortex (HP:0011035)1.91286156
112Irregular epiphyses (HP:0010582)1.91141183
113Hyperglycinuria (HP:0003108)1.90299487
114Progressive muscle weakness (HP:0003323)1.89821955
115Abnormality of the ischium (HP:0003174)1.89433445
116Abnormality of the renal medulla (HP:0100957)1.89359390
117Macular degeneration (HP:0000608)1.89016698
118Glomerulosclerosis (HP:0000096)1.87949450
119Ileus (HP:0002595)1.86224650
120Late onset (HP:0003584)1.84608518
121Patent foramen ovale (HP:0001655)1.82761747
122Fragile skin (HP:0001030)1.82031666
123Large hands (HP:0001176)1.81975809
124Abnormality of homocysteine metabolism (HP:0010919)1.81403558
125Homocystinuria (HP:0002156)1.81403558
126Severe visual impairment (HP:0001141)1.80773164
127Rectal prolapse (HP:0002035)1.80030827
128Mesangial abnormality (HP:0001966)1.79713169
129Ventricular fibrillation (HP:0001663)1.79288483
130Coxa valga (HP:0002673)1.78840013
131Infantile muscular hypotonia (HP:0008947)1.78443182
132Abnormal spermatogenesis (HP:0008669)1.78239139
133Hypoglycemic coma (HP:0001325)1.77377007
134Myocardial infarction (HP:0001658)1.76604069
135Progressive sensorineural hearing impairment (HP:0000408)1.75796224
136Abnormality of the hepatic vasculature (HP:0006707)1.75468452
137Abnormality of methionine metabolism (HP:0010901)1.75442127
138Hypoplastic ischia (HP:0003175)1.75223116
139Hypoplastic left heart (HP:0004383)1.74854579
140Disproportionate tall stature (HP:0001519)1.74553329
141Type I transferrin isoform profile (HP:0003642)1.73366991
142Enlarged penis (HP:0000040)1.73337514
143Blue sclerae (HP:0000592)1.71704326
14411 pairs of ribs (HP:0000878)1.69503544
145Nasal speech (HP:0001611)1.69285747
146Wormian bones (HP:0002645)1.69140894
147Duplicated collecting system (HP:0000081)1.69139799
148Redundant skin (HP:0001582)1.69134818
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68910244
150Abnormality of purine metabolism (HP:0004352)1.66791988
151Enlarged kidneys (HP:0000105)1.64488547
152Gaze-evoked nystagmus (HP:0000640)1.60886415
153Impaired vibratory sensation (HP:0002495)1.59738248
154Congenital sensorineural hearing impairment (HP:0008527)1.58564749
155Diaphragmatic weakness (HP:0009113)1.58090786
156Abnormality of the wing of the ilium (HP:0011867)1.54998948
157Autoimmune thrombocytopenia (HP:0001973)1.53728845
158Cupped ear (HP:0000378)1.52870377
159Abnormality of the renal collecting system (HP:0004742)1.52018223
160Abnormal biliary tract morphology (HP:0012440)1.51731181
161Abnormal hair whorl (HP:0010721)1.49422747
162Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.48251904
163Decreased circulating renin level (HP:0003351)1.45553160
164Gowers sign (HP:0003391)1.44693276
165Cone-rod dystrophy (HP:0000548)1.44079363
166Facial cleft (HP:0002006)1.42213087
167Aplasia/Hypoplasia of the sternum (HP:0006714)1.41867872
168Abnormality of the labia (HP:0000058)1.41853701
169Nonprogressive disorder (HP:0003680)1.41711852
170Abnormality of DNA repair (HP:0003254)1.41680844
171Cystic liver disease (HP:0006706)1.38156134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.83595470
2ERN15.18144548
3MAP2K24.61408548
4TRIB34.36828755
5PKN24.29370774
6EIF2AK33.83386530
7EPHA23.45272513
8ZAP702.38211871
9CDK122.30229084
10NTRK32.21516101
11BRSK21.95562282
12PAK21.88880603
13MAP2K11.80403972
14PDGFRB1.73037692
15IRAK31.70154470
16IRAK11.67382435
17LATS11.59522683
18PTK61.59170837
19SGK21.58364107
20ICK1.50798782
21AKT31.44042368
22DYRK1A1.42659256
23INSRR1.39175842
24MAPKAPK31.39041533
25RPS6KB21.36947547
26FRK1.36888890
27TAOK31.36692785
28PASK1.36239194
29SGK31.34407478
30WNK41.32298460
31EEF2K1.31101031
32CAMK1G1.30654984
33NME11.30381060
34LRRK21.30116657
35MAPK151.28930298
36PNCK1.28035962
37MELK1.18784253
38DDR21.15635575
39FLT31.08359840
40STK241.07115246
41SCYL21.04810387
42STK391.04299905
43NME21.02905755
44SGK2231.02819183
45SGK4941.02819183
46PIK3CA1.00265630
47SIK10.99740043
48NLK0.98874644
49DAPK20.96796037
50STK380.96627740
51ILK0.95569589
52EPHB10.94349051
53CAMKK10.93290860
54PDGFRA0.92974043
55PIK3CG0.86169552
56FGFR20.85227078
57MTOR0.83854733
58RIPK10.81529571
59MARK30.78942433
60MAP3K50.78004458
61PRKAA10.76832590
62PRKAA20.75229272
63RET0.73661923
64MAP2K60.72060426
65STK110.71456509
66MAP3K30.71348960
67TSSK60.70351522
68MET0.65494514
69PIM10.65075104
70MARK20.64862852
71TNIK0.64044212
72CHUK0.63654297
73MAPK70.62600774
74MUSK0.60801159
75PRKD30.59109839
76CAMK40.58871290
77FER0.57833950
78MST1R0.56875595
79CDK80.56560246
80PRKCI0.54770563
81PDPK10.53636684
82PRKCZ0.53343600
83MAP3K20.53155730
84PRKG20.52887104
85MAP3K90.52629159
86PIM20.50971696
87MAPKAPK50.49280231
88WNK10.49203753
89SGK10.48135155
90OXSR10.46551327
91EPHA30.45804411
92HIPK20.45694196
93IKBKE0.45362942
94WEE10.45202126
95MAPK120.44689959
96IRAK20.43101367
97IKBKB0.41985662
98DYRK1B0.41839504
99VRK10.40751031
100PTK20.40684553
101GSK3A0.40291804
102RPS6KA20.39556394
103GSK3B0.38678619
104CDK90.38070338
105MAPK30.38042851
106BMPR1B0.37524200
107NEK60.37307479
108BRSK10.37183249
109MAP2K30.37128989
110PRKACB0.36661324
111MAP3K10.33769102
112MAPK110.32964949
113ABL10.32934029
114MAPK80.31993218
115PDK10.31600174
116BRD40.31072757
117MAP3K70.30889480
118RPS6KB10.30785308
119NTRK10.30646463
120ERBB20.30043667
121CDK30.28807599
122TGFBR20.28738804
123IRAK40.27239746
124TYRO30.26915158
125PRKD10.26585562
126MAP3K100.26527444
127KSR20.26201000
128PDK20.25846947
129CDK20.25504867
130PTK2B0.25447381
131FGFR10.25142735
132LMTK20.24742577
133MAP3K110.23971109
134PRKCH0.23865936
135MAPK10.23549850
136MAPK100.22672401
137CSNK1A10.22046170
138RPS6KA10.22028598
139FGFR40.21908181
140MAPK140.21833997
141MAP3K80.20568101
142GRK10.18737025
143PAK40.18585368
144CDK40.18397337
145IGF1R0.18259219
146RPS6KA60.18010398
147RPS6KA30.17315073
148AKT10.17007052
149FGR0.16401699
150BMX0.16129811
151EGFR0.14789060
152TBK10.14616135
153CAMK1D0.13924101
154CSNK1E0.13793901
155MATK0.12639034
156AKT20.12377884
157TIE10.11797868
158CSNK1A1L0.11507989
159CDK190.10631035
160TAOK10.09351086

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049728.64484926
2Protein digestion and absorption_Homo sapiens_hsa049746.07993072
3Fat digestion and absorption_Homo sapiens_hsa049756.05373133
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.38968116
5Protein export_Homo sapiens_hsa030603.21787655
6Glycerolipid metabolism_Homo sapiens_hsa005613.18650807
7Folate biosynthesis_Homo sapiens_hsa007902.76666302
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.61048608
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47264804
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.21065019
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03362174
12Steroid biosynthesis_Homo sapiens_hsa001001.95793389
13Circadian rhythm_Homo sapiens_hsa047101.90793188
14Propanoate metabolism_Homo sapiens_hsa006401.61534054
15Vitamin digestion and absorption_Homo sapiens_hsa049771.60579620
16Renin-angiotensin system_Homo sapiens_hsa046141.42491754
17Arginine and proline metabolism_Homo sapiens_hsa003301.33831847
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17907086
19N-Glycan biosynthesis_Homo sapiens_hsa005100.99707583
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95895391
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91753483
22Linoleic acid metabolism_Homo sapiens_hsa005910.89120118
23Biosynthesis of amino acids_Homo sapiens_hsa012300.85168947
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84755587
25Starch and sucrose metabolism_Homo sapiens_hsa005000.78772084
26Influenza A_Homo sapiens_hsa051640.77963651
27One carbon pool by folate_Homo sapiens_hsa006700.75795432
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75430139
29Cysteine and methionine metabolism_Homo sapiens_hsa002700.71169770
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69787455
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68543650
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67573930
33Selenocompound metabolism_Homo sapiens_hsa004500.66477501
34Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66440122
35beta-Alanine metabolism_Homo sapiens_hsa004100.64491036
36Other glycan degradation_Homo sapiens_hsa005110.61691696
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60957326
38Vibrio cholerae infection_Homo sapiens_hsa051100.60769606
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56047362
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53806571
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53613503
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53197468
43Fatty acid degradation_Homo sapiens_hsa000710.51990648
44Insulin secretion_Homo sapiens_hsa049110.50495658
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.46521120
46Glutathione metabolism_Homo sapiens_hsa004800.43850853
47Legionellosis_Homo sapiens_hsa051340.43153625
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41973984
49Ether lipid metabolism_Homo sapiens_hsa005650.40886262
50Pyruvate metabolism_Homo sapiens_hsa006200.40784282
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40029437
52Endometrial cancer_Homo sapiens_hsa052130.39877710
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39710588
54Phototransduction_Homo sapiens_hsa047440.39373212
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38961123
56Sulfur metabolism_Homo sapiens_hsa009200.37767560
57VEGF signaling pathway_Homo sapiens_hsa043700.35141004
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.35066417
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.34044528
60Tryptophan metabolism_Homo sapiens_hsa003800.33280605
61Arachidonic acid metabolism_Homo sapiens_hsa005900.32838080
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32608644
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31247093
64Viral myocarditis_Homo sapiens_hsa054160.29858474
65Sulfur relay system_Homo sapiens_hsa041220.29523725
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28839781
67Histidine metabolism_Homo sapiens_hsa003400.28140745
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27806133
69Lysosome_Homo sapiens_hsa041420.27684649
70ECM-receptor interaction_Homo sapiens_hsa045120.25435268
71Metabolic pathways_Homo sapiens_hsa011000.24798001
72Mineral absorption_Homo sapiens_hsa049780.22458079
73Bile secretion_Homo sapiens_hsa049760.22442845
74Prostate cancer_Homo sapiens_hsa052150.21980047
75ABC transporters_Homo sapiens_hsa020100.21557907
76FoxO signaling pathway_Homo sapiens_hsa040680.18284515
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17067339
78Ribosome_Homo sapiens_hsa030100.16529820
79Ras signaling pathway_Homo sapiens_hsa040140.15113102
80Carbon metabolism_Homo sapiens_hsa012000.14503279
81Tight junction_Homo sapiens_hsa045300.14377845
82Fatty acid metabolism_Homo sapiens_hsa012120.14061613
83Calcium signaling pathway_Homo sapiens_hsa040200.13548608
84Bladder cancer_Homo sapiens_hsa052190.13525903
85Arginine biosynthesis_Homo sapiens_hsa002200.12345472
86Toxoplasmosis_Homo sapiens_hsa051450.12244179
87Fatty acid elongation_Homo sapiens_hsa000620.12103723
88* Notch signaling pathway_Homo sapiens_hsa043300.11565450
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11224216
90Lysine degradation_Homo sapiens_hsa003100.10862682
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.10763951
92Fructose and mannose metabolism_Homo sapiens_hsa000510.10263920
93Pancreatic cancer_Homo sapiens_hsa052120.10259776
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09838315
95Regulation of autophagy_Homo sapiens_hsa041400.09644633
96Non-small cell lung cancer_Homo sapiens_hsa052230.09133537
97TGF-beta signaling pathway_Homo sapiens_hsa043500.08963994
98Hepatitis C_Homo sapiens_hsa051600.08826779
99ErbB signaling pathway_Homo sapiens_hsa040120.08423272
100Estrogen signaling pathway_Homo sapiens_hsa049150.08203094
101Thyroid hormone synthesis_Homo sapiens_hsa049180.07019128
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.06871265
103MAPK signaling pathway_Homo sapiens_hsa040100.06690401
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06572213
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.05743718
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.05588784
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05330308
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.05195521
109Alzheimers disease_Homo sapiens_hsa050100.05160890
110Vitamin B6 metabolism_Homo sapiens_hsa007500.04962783
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.04436862
112Taste transduction_Homo sapiens_hsa047420.04293133
113Oocyte meiosis_Homo sapiens_hsa041140.04225088
114Small cell lung cancer_Homo sapiens_hsa052220.03979173
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.03509405
116Colorectal cancer_Homo sapiens_hsa052100.03457524
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.03074071
118Parkinsons disease_Homo sapiens_hsa050120.02960962
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.02600803
120Cocaine addiction_Homo sapiens_hsa050300.02197358
121mTOR signaling pathway_Homo sapiens_hsa041500.02116119
122RNA transport_Homo sapiens_hsa030130.02059414
123Insulin resistance_Homo sapiens_hsa049310.01797195
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.01737669
125Dorso-ventral axis formation_Homo sapiens_hsa043200.01721538
126mRNA surveillance pathway_Homo sapiens_hsa030150.01521398
127AMPK signaling pathway_Homo sapiens_hsa041520.01506889
128Glucagon signaling pathway_Homo sapiens_hsa049220.01263963
129Adherens junction_Homo sapiens_hsa045200.00639144
130Peroxisome_Homo sapiens_hsa041460.00238791
131Prolactin signaling pathway_Homo sapiens_hsa04917-0.0802744
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0745648
133Phosphatidylinositol signaling system_Homo sapiens_hsa04070-0.0726804
134HTLV-I infection_Homo sapiens_hsa05166-0.0635637
135Chemical carcinogenesis_Homo sapiens_hsa05204-0.0598808
136NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0564048
137Glutamatergic synapse_Homo sapiens_hsa04724-0.0515011
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0493766
139Long-term potentiation_Homo sapiens_hsa04720-0.0480074
140Wnt signaling pathway_Homo sapiens_hsa04310-0.0469404
141Complement and coagulation cascades_Homo sapiens_hsa04610-0.0417474
142Chronic myeloid leukemia_Homo sapiens_hsa05220-0.0400182
143Retinol metabolism_Homo sapiens_hsa00830-0.0391734
144Amphetamine addiction_Homo sapiens_hsa05031-0.0323244
145Herpes simplex infection_Homo sapiens_hsa05168-0.0313840
146Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0247090
147Choline metabolism in cancer_Homo sapiens_hsa05231-0.0154701
148Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0118880
149TNF signaling pathway_Homo sapiens_hsa04668-0.0085186
150Gastric acid secretion_Homo sapiens_hsa04971-0.0062445
151Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0033374

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