ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.33499282
2	cytidine deamination (GO:0009972)	5.77887332
3	cytidine metabolic process (GO:0046087)	5.77887332
4	cytidine catabolic process (GO:0006216)	5.77887332
5	positive regulation of cell fate commitment (GO:0010455)	5.52384878
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.42169388
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.09840022
8	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.94256743
9	regulation of activation of Janus kinase activity (GO:0010533)	4.71128780
10	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	4.49889122
11	regulation of memory T cell differentiation (GO:0043380)	4.22392809
12	positive regulation of interleukin-17 production (GO:0032740)	4.04043768
13	dopamine transport (GO:0015872)	4.01206544
14	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.99881277
15	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.98899166
16	positive regulation of defense response to virus by host (GO:0002230)	3.98526590
17	behavioral response to nicotine (GO:0035095)	3.95209123
18	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.85161528
19	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.77760357
20	fusion of sperm to egg plasma membrane (GO:0007342)	3.75703214
21	positive regulation of T-helper 1 type immune response (GO:0002827)	3.57654029
22	regulation of T cell mediated cytotoxicity (GO:0001914)	3.48455862
23	signal peptide processing (GO:0006465)	3.47916792
24	ribosomal small subunit assembly (GO:0000028)	3.39824116
25	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.37742439
26	positive regulation of action potential (GO:0045760)	3.34388321
27	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.31815665
28	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.29625489
29	ATP synthesis coupled proton transport (GO:0015986)	3.28481742
30	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.28481742
31	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.28455753
32	negative regulation of heart rate (GO:0010459)	3.24294238
33	water-soluble vitamin biosynthetic process (GO:0042364)	3.22690892
34	protein complex biogenesis (GO:0070271)	3.18222356
35	plasma membrane fusion (GO:0045026)	3.17817200
36	neuronal action potential (GO:0019228)	3.17627916
37	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.17026097
38	molting cycle (GO:0042303)	3.12060831
39	hair cycle (GO:0042633)	3.12060831
40	piRNA metabolic process (GO:0034587)	3.11091356
41	detection of light stimulus involved in visual perception (GO:0050908)	3.09405837
42	detection of light stimulus involved in sensory perception (GO:0050962)	3.09405837
43	transmission of nerve impulse (GO:0019226)	3.06877917
44	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.01910444
45	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.00367057
46	mitochondrial respiratory chain complex assembly (GO:0033108)	2.99962913
47	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.92417830
48	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.92417830
49	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.91142671
50	negative regulation of interleukin-10 production (GO:0032693)	2.90020416
51	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.84485145
52	protein polyglutamylation (GO:0018095)	2.84387553
53	regulation of action potential (GO:0098900)	2.83965518
54	photoreceptor cell maintenance (GO:0045494)	2.83291973
55	response to pheromone (GO:0019236)	2.81914259
56	kynurenine metabolic process (GO:0070189)	2.80879248
57	positive regulation of protein homodimerization activity (GO:0090073)	2.80833808
58	pyrimidine nucleoside catabolic process (GO:0046135)	2.78238178
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.76715981
60	preassembly of GPI anchor in ER membrane (GO:0016254)	2.76216072
61	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.75794350
62	regulation of uterine smooth muscle contraction (GO:0070472)	2.74766815
63	negative regulation of monooxygenase activity (GO:0032769)	2.71874664
64	positive regulation of T cell mediated immunity (GO:0002711)	2.70279191
65	positive regulation of cell killing (GO:0031343)	2.69633625
66	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.67646567
67	leukotriene biosynthetic process (GO:0019370)	2.66239484
68	indole-containing compound metabolic process (GO:0042430)	2.65318245
69	regulation of vitamin metabolic process (GO:0030656)	2.63720136
70	regulation of T-helper 1 type immune response (GO:0002825)	2.62625352
71	DNA methylation involved in gamete generation (GO:0043046)	2.62377379
72	regulation of vitamin D biosynthetic process (GO:0060556)	2.62356520
73	auditory receptor cell stereocilium organization (GO:0060088)	2.61451719
74	secondary heart field specification (GO:0003139)	2.60027329
75	heart field specification (GO:0003128)	2.60027329
76	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.58545402
77	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.58545402
78	regulation of acrosome reaction (GO:0060046)	2.56394471
79	tryptophan metabolic process (GO:0006568)	2.55302589
80	positive thymic T cell selection (GO:0045059)	2.53855423
81	histone H2A acetylation (GO:0043968)	2.53758695
82	adenosine metabolic process (GO:0046085)	2.53369638
83	regulation of cell communication by electrical coupling (GO:0010649)	2.51766485
84	axoneme assembly (GO:0035082)	2.51351633
85	synaptic transmission, cholinergic (GO:0007271)	2.51341219
86	negative regulation of mast cell activation (GO:0033004)	2.49133484
87	adaptation of signaling pathway (GO:0023058)	2.48059600
88	indolalkylamine metabolic process (GO:0006586)	2.47317640
89	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.46580916
90	ribosomal large subunit biogenesis (GO:0042273)	2.46576678
91	indole-containing compound catabolic process (GO:0042436)	2.44415721
92	indolalkylamine catabolic process (GO:0046218)	2.44415721
93	tryptophan catabolic process (GO:0006569)	2.44415721
94	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.42403832
95	peristalsis (GO:0030432)	2.40889075
96	L-fucose catabolic process (GO:0042355)	2.40524164
97	fucose catabolic process (GO:0019317)	2.40524164
98	L-fucose metabolic process (GO:0042354)	2.40524164
99	electron transport chain (GO:0022900)	2.39824011
100	respiratory electron transport chain (GO:0022904)	2.39815249

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.92327637
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.53873574
3	GATA1_22025678_ChIP-Seq_K562_Human	3.47838755
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.40466637
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.79579782
6	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.64550529
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.47180502
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.35229997
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30392360
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.15431072
11	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.11899124
12	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.11381954
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.08407838
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.04522711
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03777444
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.03767266
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.02910499
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.02126493
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.99714778
20	EWS_26573619_Chip-Seq_HEK293_Human	1.95757070
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.90730660
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.89499407
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89000573
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.87887759
25	FUS_26573619_Chip-Seq_HEK293_Human	1.87227013
26	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.84943296
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.81932067
28	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.80425138
29	P300_19829295_ChIP-Seq_ESCs_Human	1.79987056
30	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79652593
31	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.73864858
32	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68739642
33	NANOG_19829295_ChIP-Seq_ESCs_Human	1.66224738
34	SOX2_19829295_ChIP-Seq_ESCs_Human	1.66224738
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66013560
36	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.65883570
37	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.56268701
38	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.54314918
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.53190411
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.53190411
41	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.53005221
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51677123
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.49188756
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.48786918
45	GATA3_26560356_Chip-Seq_TH2_Human	1.46391160
46	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.43066655
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40615815
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36827372
49	VDR_23849224_ChIP-Seq_CD4+_Human	1.34680903
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34512046
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34295220
52	MYB_26560356_Chip-Seq_TH2_Human	1.32473935
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29574752
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27632743
55	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.24635177
56	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23864374
57	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.23598509
58	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.22091913
59	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.22027959
60	AR_20517297_ChIP-Seq_VCAP_Human	1.20846551
61	BCAT_22108803_ChIP-Seq_LS180_Human	1.19753147
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18649538
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.17013172
64	RUNX_20019798_ChIP-Seq_JUKART_Human	1.15474073
65	NCOR_22424771_ChIP-Seq_293T_Human	1.14831428
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14015396
67	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.13968663
68	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12205287
69	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11820248
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.10337326
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.10003636
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08666049
73	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.07909354
74	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07755625
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07411649
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06316338
77	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06314633
78	AR_21572438_ChIP-Seq_LNCaP_Human	1.05498252
79	STAT3_23295773_ChIP-Seq_U87_Human	1.04800071
80	CBP_20019798_ChIP-Seq_JUKART_Human	1.04052294
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.04052294
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03999013
83	ERG_20517297_ChIP-Seq_VCAP_Human	1.03071996
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02902240
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01932414
86	TCF4_22108803_ChIP-Seq_LS180_Human	1.01648680
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01171224
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00403867
89	TCF4_23295773_ChIP-Seq_U87_Human	0.99871145
90	AR_25329375_ChIP-Seq_VCAP_Human	0.97027276
91	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.95806483
92	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.95732524
93	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.95207278
94	GATA3_26560356_Chip-Seq_TH1_Human	0.94580693
95	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.94424319
96	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.94247093
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.93973574
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93733292
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93384107
100	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92093407

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.95784328
2	MP0006292_abnormal_olfactory_placode	4.20919503
3	MP0003283_abnormal_digestive_organ	3.22822429
4	MP0009379_abnormal_foot_pigmentation	3.05373073
5	MP0005671_abnormal_response_to	3.01433755
6	MP0003195_calcinosis	2.84430352
7	MP0009333_abnormal_splenocyte_physiolog	2.57574108
8	MP0009785_altered_susceptibility_to	2.39489665
9	MP0001529_abnormal_vocalization	2.35887175
10	MP0001485_abnormal_pinna_reflex	2.35543787
11	MP0005645_abnormal_hypothalamus_physiol	2.25228280
12	MP0005377_hearing/vestibular/ear_phenot	2.21570443
13	MP0003878_abnormal_ear_physiology	2.21570443
14	MP0001835_abnormal_antigen_presentation	2.21018237
15	MP0005551_abnormal_eye_electrophysiolog	2.05426596
16	MP0008995_early_reproductive_senescence	2.02852442
17	MP0008877_abnormal_DNA_methylation	2.02513763
18	MP0006054_spinal_hemorrhage	1.98012457
19	MP0005075_abnormal_melanosome_morpholog	1.95209829
20	MP0002837_dystrophic_cardiac_calcinosis	1.78983642
21	MP0004885_abnormal_endolymph	1.70163632
22	MP0008872_abnormal_physiological_respon	1.70091354
23	MP0001800_abnormal_humoral_immune	1.60881290
24	MP0006276_abnormal_autonomic_nervous	1.58258387
25	MP0003567_abnormal_fetal_cardiomyocyte	1.57230329
26	MP0005646_abnormal_pituitary_gland	1.56170947
27	MP0005000_abnormal_immune_tolerance	1.44605625
28	MP0002277_abnormal_respiratory_mucosa	1.41807522
29	MP0002234_abnormal_pharynx_morphology	1.41224852
30	MP0003183_abnormal_peptide_metabolism	1.39382846
31	MP0002102_abnormal_ear_morphology	1.38858511
32	MP0002736_abnormal_nociception_after	1.37281036
33	MP0008775_abnormal_heart_ventricle	1.37154558
34	MP0005084_abnormal_gallbladder_morpholo	1.35874816
35	MP0004133_heterotaxia	1.35596668
36	MP0001968_abnormal_touch/_nociception	1.35557605
37	MP0001486_abnormal_startle_reflex	1.33578379
38	MP0001873_stomach_inflammation	1.33413105
39	MP0005389_reproductive_system_phenotype	1.31799015
40	MP0006072_abnormal_retinal_apoptosis	1.30796115
41	MP0005367_renal/urinary_system_phenotyp	1.28657293
42	MP0000516_abnormal_urinary_system	1.28657293
43	MP0002723_abnormal_immune_serum	1.28307309
44	MP0001986_abnormal_taste_sensitivity	1.28251688
45	MP0000372_irregular_coat_pigmentation	1.26771524
46	MP0001919_abnormal_reproductive_system	1.25402193
47	MP0003763_abnormal_thymus_physiology	1.23717588
48	MP0002148_abnormal_hypersensitivity_rea	1.18005931
49	MP0006082_CNS_inflammation	1.17608562
50	MP0001501_abnormal_sleep_pattern	1.13907953
51	MP0008875_abnormal_xenobiotic_pharmacok	1.12444989
52	MP0004142_abnormal_muscle_tone	1.10877010
53	MP0003866_abnormal_defecation	1.09919898
54	MP0002405_respiratory_system_inflammati	1.07747506
55	MP0000566_synostosis	1.06185757
56	MP0004043_abnormal_pH_regulation	1.06068348
57	MP0002138_abnormal_hepatobiliary_system	1.05985389
58	MP0002420_abnormal_adaptive_immunity	1.05885600
59	MP0001905_abnormal_dopamine_level	1.05156440
60	MP0001819_abnormal_immune_cell	1.04346222
61	MP0002272_abnormal_nervous_system	1.03329861
62	MP0001963_abnormal_hearing_physiology	1.02232058
63	MP0003938_abnormal_ear_development	1.01926509
64	MP0004742_abnormal_vestibular_system	0.97961592
65	MP0005085_abnormal_gallbladder_physiolo	0.97617459
66	MP0002452_abnormal_antigen_presenting	0.97528964
67	MP0009745_abnormal_behavioral_response	0.96320980
68	MP0001790_abnormal_immune_system	0.94417165
69	MP0005387_immune_system_phenotype	0.94417165
70	MP0002938_white_spotting	0.94125916
71	MP0001765_abnormal_ion_homeostasis	0.93923981
72	MP0005025_abnormal_response_to	0.93435727
73	MP0002160_abnormal_reproductive_system	0.92145377
74	MP0008789_abnormal_olfactory_epithelium	0.90442399
75	MP0001845_abnormal_inflammatory_respons	0.86804723
76	MP0003646_muscle_fatigue	0.85804128
77	MP0003786_premature_aging	0.85641591
78	MP0003638_abnormal_response/metabolism_	0.85570418
79	MP0003011_delayed_dark_adaptation	0.85043491
80	MP0010155_abnormal_intestine_physiology	0.84937614
81	MP0005220_abnormal_exocrine_pancreas	0.83645613
82	MP0002733_abnormal_thermal_nociception	0.81637791
83	MP0005636_abnormal_mineral_homeostasis	0.81286395
84	MP0002693_abnormal_pancreas_physiology	0.77164337
85	MP0004215_abnormal_myocardial_fiber	0.76606090
86	MP0000538_abnormal_urinary_bladder	0.76165449
87	MP0009764_decreased_sensitivity_to	0.76061185
88	MP0000716_abnormal_immune_system	0.73479165
89	MP0000230_abnormal_systemic_arterial	0.71172811
90	MP0000569_abnormal_digit_pigmentation	0.71128711
91	MP0000026_abnormal_inner_ear	0.70887854
92	MP0001764_abnormal_homeostasis	0.69310747
93	MP0001970_abnormal_pain_threshold	0.68946464
94	MP0002909_abnormal_adrenal_gland	0.68807395
95	MP0005410_abnormal_fertilization	0.68490713
96	MP0005253_abnormal_eye_physiology	0.68384495
97	MP0001188_hyperpigmentation	0.67476821
98	MP0005167_abnormal_blood-brain_barrier	0.64953643
99	MP0000383_abnormal_hair_follicle	0.64726496
100	MP0002398_abnormal_bone_marrow	0.64709156

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Retrobulbar optic neuritis (HP:0100654)	5.49639687
2	Optic neuritis (HP:0100653)	5.49639687
3	Orchitis (HP:0100796)	4.57100972
4	Myositis (HP:0100614)	4.12816595
5	Keratoconjunctivitis (HP:0001096)	4.04738728
6	B lymphocytopenia (HP:0010976)	3.89703839
7	Keratoconjunctivitis sicca (HP:0001097)	3.84006106
8	Abnormality of B cell number (HP:0010975)	3.79805418
9	Generalized aminoaciduria (HP:0002909)	3.75046130
10	Absent/shortened dynein arms (HP:0200106)	3.49667539
11	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.49667539
12	Pancreatic cysts (HP:0001737)	3.44182685
13	Abolished electroretinogram (ERG) (HP:0000550)	3.39140618
14	Hypothermia (HP:0002045)	3.22566874
15	Congenital stationary night blindness (HP:0007642)	3.22479692
16	Elevated erythrocyte sedimentation rate (HP:0003565)	3.21289687
17	3-Methylglutaconic aciduria (HP:0003535)	3.10188561
18	Mitochondrial inheritance (HP:0001427)	2.94927428
19	Pendular nystagmus (HP:0012043)	2.93459764
20	Congenital sensorineural hearing impairment (HP:0008527)	2.88382874
21	Encephalitis (HP:0002383)	2.82103084
22	Hepatocellular necrosis (HP:0001404)	2.79658811
23	Increased CSF lactate (HP:0002490)	2.77407355
24	Attenuation of retinal blood vessels (HP:0007843)	2.70959529
25	Pulmonary infiltrates (HP:0002113)	2.65636948
26	Lipid accumulation in hepatocytes (HP:0006561)	2.65355644
27	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.64455743
28	Abnormality of the renal cortex (HP:0011035)	2.62541704
29	Hypoalbuminemia (HP:0003073)	2.58596847
30	Abnormal albumin level (HP:0012116)	2.58596847
31	Congenital, generalized hypertrichosis (HP:0004540)	2.57387684
32	IgG deficiency (HP:0004315)	2.56978918
33	Acute necrotizing encephalopathy (HP:0006965)	2.54466651
34	Increased hepatocellular lipid droplets (HP:0006565)	2.53503271
35	Nephronophthisis (HP:0000090)	2.52893529
36	Renal cortical cysts (HP:0000803)	2.50934230
37	Increased corneal curvature (HP:0100692)	2.49866596
38	Keratoconus (HP:0000563)	2.49866596
39	Hypoproteinemia (HP:0003075)	2.46878269
40	Hepatic necrosis (HP:0002605)	2.45113012
41	True hermaphroditism (HP:0010459)	2.44611925
42	Abnormal mitochondria in muscle tissue (HP:0008316)	2.41963447
43	Pancreatic fibrosis (HP:0100732)	2.41553863
44	Renal Fanconi syndrome (HP:0001994)	2.39933574
45	Abnormality of the renal medulla (HP:0100957)	2.36085950
46	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.33559210
47	Progressive macrocephaly (HP:0004481)	2.32609422
48	Abnormal respiratory epithelium morphology (HP:0012253)	2.30360208
49	Abnormal respiratory motile cilium morphology (HP:0005938)	2.30360208
50	Severe visual impairment (HP:0001141)	2.27040671
51	Adactyly (HP:0009776)	2.26340229
52	Gangrene (HP:0100758)	2.25586345
53	Abnormal ciliary motility (HP:0012262)	2.25449409
54	Optic nerve hypoplasia (HP:0000609)	2.22359495
55	Medial flaring of the eyebrow (HP:0010747)	2.21345857
56	Decreased central vision (HP:0007663)	2.19100541
57	Increased intramyocellular lipid droplets (HP:0012240)	2.18404833
58	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.17162372
59	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.17162372
60	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.15140139
61	Abnormality of midbrain morphology (HP:0002418)	2.14310469
62	Molar tooth sign on MRI (HP:0002419)	2.14310469
63	T lymphocytopenia (HP:0005403)	2.13735071
64	Exertional dyspnea (HP:0002875)	2.10317365
65	Increased muscle lipid content (HP:0009058)	2.08365861
66	Type I transferrin isoform profile (HP:0003642)	2.08052377
67	Keratitis (HP:0000491)	2.07027877
68	Azoospermia (HP:0000027)	2.06398180
69	Methylmalonic acidemia (HP:0002912)	2.05656315
70	Abnormality of urine glucose concentration (HP:0011016)	2.04215419
71	Glycosuria (HP:0003076)	2.04215419
72	Facial diplegia (HP:0001349)	2.03350431
73	Abnormality of the pleura (HP:0002103)	2.02475937
74	Abnormality of T cell number (HP:0011839)	1.99254202
75	Polyneuropathy (HP:0001271)	1.99004958
76	Pulmonary embolism (HP:0002204)	1.93935426
77	Hemoptysis (HP:0002105)	1.92694146
78	Cerebral edema (HP:0002181)	1.91005592
79	Abnormality of macular pigmentation (HP:0008002)	1.90894197
80	Congenital hepatic fibrosis (HP:0002612)	1.90736142
81	Panhypogammaglobulinemia (HP:0003139)	1.90438994
82	Bony spicule pigmentary retinopathy (HP:0007737)	1.89626743
83	Abnormal spermatogenesis (HP:0008669)	1.88633162
84	Abnormality of dental color (HP:0011073)	1.86940415
85	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.85789693
86	Potter facies (HP:0002009)	1.84781118
87	Facial shape deformation (HP:0011334)	1.84781118
88	Acute encephalopathy (HP:0006846)	1.84688742
89	Reduced antithrombin III activity (HP:0001976)	1.84654315
90	Cystic liver disease (HP:0006706)	1.84249772
91	Arthropathy (HP:0003040)	1.81701263
92	Hyperphosphaturia (HP:0003109)	1.81610644
93	Abnormal respiratory motile cilium physiology (HP:0012261)	1.80183765
94	Conical tooth (HP:0000698)	1.79689417
95	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.78505484
96	Septo-optic dysplasia (HP:0100842)	1.77632835
97	Abnormality of vitamin B metabolism (HP:0004340)	1.73741633
98	Vertigo (HP:0002321)	1.73404546
99	Optic disc pallor (HP:0000543)	1.72866862
100	Sclerocornea (HP:0000647)	1.72720499

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.37134043
2	TXK	4.05286489
3	MAP4K2	3.33718383
4	BCKDK	3.16536082
5	FRK	3.05939237
6	INSRR	2.61063601
7	TLK1	2.38272424
8	MST4	2.31722838
9	STK16	2.20940509
10	NUAK1	2.18042125
11	MAP4K1	2.08877462
12	ZAK	2.05718990
13	ADRBK2	2.05117151
14	TIE1	1.90043011
15	KDR	1.86096537
16	GRK6	1.85730278
17	BMPR2	1.80287869
18	TNIK	1.75964029
19	MAP2K6	1.71414281
20	GRK1	1.68483248
21	MAP3K12	1.65913626
22	BMPR1B	1.58286867
23	WNK3	1.57022492
24	MATK	1.40628958
25	ERBB3	1.39988786
26	SCYL2	1.24534466
27	SYK	1.14554970
28	KIT	1.14371355
29	CDK19	1.10520648
30	PHKG2	1.09709575
31	PHKG1	1.09709575
32	PRKCQ	1.09192565
33	ITK	1.08989694
34	ACVR1B	1.07461263
35	EIF2AK3	1.02723357
36	TEC	1.02656453
37	IKBKB	1.02401670
38	BTK	1.00369355
39	SIK2	0.99773221
40	MYLK	0.98781881
41	FGFR2	0.98008667
42	EPHA3	0.95800634
43	WNK4	0.95727708
44	GRK7	0.95013825
45	PASK	0.93984344
46	CAMKK2	0.92542906
47	IKBKE	0.89581623
48	TRPM7	0.85959317
49	PTK2B	0.84514548
50	LYN	0.81259647
51	DAPK2	0.75531527
52	OBSCN	0.73305479
53	LCK	0.72728586
54	MARK3	0.67486256
55	NTRK3	0.63642412
56	ADRBK1	0.61980987
57	MAP3K9	0.59640425
58	TGFBR2	0.57905238
59	TGFBR1	0.57264790
60	ILK	0.55518749
61	PIK3CA	0.54791779
62	VRK1	0.54382253
63	HCK	0.53893936
64	PRKCH	0.53623294
65	PINK1	0.53197520
66	WNK1	0.51619528
67	FES	0.49771742
68	ZAP70	0.49767769
69	CHUK	0.47983970
70	STK11	0.44720203
71	STK4	0.44048692
72	PRKACA	0.42494378
73	EGFR	0.42025775
74	IGF1R	0.41065645
75	PRKCA	0.41053745
76	PRKCE	0.40974780
77	RPS6KA5	0.40395617
78	SIK3	0.38294138
79	JAK3	0.37297096
80	MAPK13	0.35036902
81	CSNK1A1	0.34697125
82	NLK	0.34286151
83	INSR	0.34107468
84	TESK2	0.32834760
85	PKN1	0.32081441
86	DAPK3	0.31247203
87	PRKACB	0.30681268
88	TNK2	0.28705837
89	MUSK	0.28642263
90	STK3	0.28476425
91	DYRK2	0.27135671
92	ABL1	0.26879771
93	DAPK1	0.26809852
94	OXSR1	0.26508062
95	STK38L	0.26428129
96	NTRK2	0.25964458
97	PRKCG	0.25792301
98	CSNK2A1	0.24576831
99	AURKB	0.24347021
100	ROCK1	0.24174610

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.51088576
2	Asthma_Homo sapiens_hsa05310	3.42202295
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.18798774
4	Allograft rejection_Homo sapiens_hsa05330	2.79331854
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.74804816
6	Ribosome_Homo sapiens_hsa03010	2.59958562
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.52486954
8	Phototransduction_Homo sapiens_hsa04744	2.42011881
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.41885248
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.38576867
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.26642844
12	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.26501545
13	Primary immunodeficiency_Homo sapiens_hsa05340	2.12899599
14	Parkinsons disease_Homo sapiens_hsa05012	2.05884689
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.97737620
16	RNA polymerase_Homo sapiens_hsa03020	1.96858763
17	Homologous recombination_Homo sapiens_hsa03440	1.95018479
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.92074740
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.85939351
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.68655156
21	Nicotine addiction_Homo sapiens_hsa05033	1.59016619
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.53217605
23	Taste transduction_Homo sapiens_hsa04742	1.45938012
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.45741441
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.44909064
26	Alzheimers disease_Homo sapiens_hsa05010	1.41533741
27	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.38675839
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.36709636
29	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.33391256
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.30934455
31	Huntingtons disease_Homo sapiens_hsa05016	1.27422331
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.25799353
33	Rheumatoid arthritis_Homo sapiens_hsa05323	1.21588005
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.20563546
35	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.20129807
36	Protein export_Homo sapiens_hsa03060	1.19373042
37	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.19065802
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14433982
39	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.10240135
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.09186226
41	One carbon pool by folate_Homo sapiens_hsa00670	1.06825746
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.99390602
43	Retinol metabolism_Homo sapiens_hsa00830	0.91684659
44	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.90679552
45	Purine metabolism_Homo sapiens_hsa00230	0.87265521
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.85683769
47	RNA degradation_Homo sapiens_hsa03018	0.85663462
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83485019
49	Viral myocarditis_Homo sapiens_hsa05416	0.83369473
50	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.81811599
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81669470
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.81563254
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81260095
54	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.80604326
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80228219
56	Butanoate metabolism_Homo sapiens_hsa00650	0.80112565
57	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.78910649
58	ABC transporters_Homo sapiens_hsa02010	0.77685468
59	Morphine addiction_Homo sapiens_hsa05032	0.75709193
60	Propanoate metabolism_Homo sapiens_hsa00640	0.75260376
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.70419760
62	Olfactory transduction_Homo sapiens_hsa04740	0.69725397
63	Leishmaniasis_Homo sapiens_hsa05140	0.67752314
64	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.67022997
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.65248466
66	Regulation of autophagy_Homo sapiens_hsa04140	0.64444312
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.63095886
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61302791
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.60047050
70	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.59764837
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58769786
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58484028
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57362954
74	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.56348756
75	Basal transcription factors_Homo sapiens_hsa03022	0.54421864
76	African trypanosomiasis_Homo sapiens_hsa05143	0.52887942
77	Fanconi anemia pathway_Homo sapiens_hsa03460	0.52763475
78	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51666990
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.51171898
80	Sulfur metabolism_Homo sapiens_hsa00920	0.50769880
81	Renin-angiotensin system_Homo sapiens_hsa04614	0.50319595
82	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.48194778
83	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.47934437
84	GABAergic synapse_Homo sapiens_hsa04727	0.46713792
85	Salivary secretion_Homo sapiens_hsa04970	0.42834614
86	Caffeine metabolism_Homo sapiens_hsa00232	0.42732216
87	Amphetamine addiction_Homo sapiens_hsa05031	0.41443832
88	Serotonergic synapse_Homo sapiens_hsa04726	0.39864842
89	Metabolic pathways_Homo sapiens_hsa01100	0.39239861
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38407151
91	Alcoholism_Homo sapiens_hsa05034	0.36426545
92	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.34929420
93	Malaria_Homo sapiens_hsa05144	0.33959924
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.33427415
95	Peroxisome_Homo sapiens_hsa04146	0.30741893
96	Circadian entrainment_Homo sapiens_hsa04713	0.30277633
97	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.28674215
98	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.27862137
99	Tuberculosis_Homo sapiens_hsa05152	0.26178005
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.25591867

RBPJP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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