RBPMS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1planar cell polarity pathway involved in neural tube closure (GO:0090179)4.43225404
2sarcomere organization (GO:0045214)4.21486663
3cardiac myofibril assembly (GO:0055003)4.15493646
4regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.07493068
5regulation of gene silencing by RNA (GO:0060966)4.03680242
6regulation of posttranscriptional gene silencing (GO:0060147)4.03680242
7regulation of gene silencing by miRNA (GO:0060964)4.03680242
8endothelial cell morphogenesis (GO:0001886)3.89593572
9positive regulation of catenin import into nucleus (GO:0035413)3.85062925
10cardiac muscle cell development (GO:0055013)3.83678066
11convergent extension (GO:0060026)3.73728477
12paraxial mesoderm development (GO:0048339)3.64295785
13regulation of cardioblast differentiation (GO:0051890)3.63940853
14regulation of cell fate specification (GO:0042659)3.63226980
15bundle of His cell to Purkinje myocyte communication (GO:0086069)3.60873644
16cardiac cell development (GO:0055006)3.58639499
17lung-associated mesenchyme development (GO:0060484)3.55975721
18branching involved in salivary gland morphogenesis (GO:0060445)3.48593476
19bone trabecula formation (GO:0060346)3.47630620
20atrioventricular valve morphogenesis (GO:0003181)3.41166038
21formation of translation preinitiation complex (GO:0001731)3.39806976
22regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.32340382
23myofibril assembly (GO:0030239)3.29313163
24endocardial cushion development (GO:0003197)3.27813633
25protein heterotrimerization (GO:0070208)3.25492601
26cell migration involved in heart development (GO:0060973)3.22910131
27Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.22587507
28ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.17921968
29outer ear morphogenesis (GO:0042473)3.17811588
30non-canonical Wnt signaling pathway (GO:0035567)3.15536576
31cell migration involved in sprouting angiogenesis (GO:0002042)3.14442209
32cardiac muscle tissue morphogenesis (GO:0055008)3.09936581
33hippo signaling (GO:0035329)3.09615493
34tricarboxylic acid cycle (GO:0006099)3.06773324
35regulation of establishment of planar polarity (GO:0090175)3.06082515
36regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.05717965
37chondrocyte proliferation (GO:0035988)3.04769900
38G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.03998308
39negative regulation of androgen receptor signaling pathway (GO:0060766)3.03951539
40regulation of catenin import into nucleus (GO:0035412)3.03105544
41heart trabecula formation (GO:0060347)3.02896715
42folic acid-containing compound biosynthetic process (GO:0009396)3.00888090
43regulation of stem cell maintenance (GO:2000036)3.00764922
44adherens junction assembly (GO:0034333)2.99735620
45negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.98595829
46regulation of hippo signaling (GO:0035330)2.91435270
47endodermal cell differentiation (GO:0035987)2.90629956
48purine nucleobase biosynthetic process (GO:0009113)2.90119768
49regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.89074810
50nucleobase biosynthetic process (GO:0046112)2.88683961
51ventricular cardiac muscle cell development (GO:0055015)2.88663946
52collagen fibril organization (GO:0030199)2.85832045
53atrial septum morphogenesis (GO:0060413)2.84914593
54metanephric mesenchyme development (GO:0072075)2.84650194
55carnitine shuttle (GO:0006853)2.84269141
56extracellular matrix assembly (GO:0085029)2.84234861
57cell-substrate adherens junction assembly (GO:0007045)2.83474978
58focal adhesion assembly (GO:0048041)2.83474978
59regulation of gastrulation (GO:0010470)2.82146071
60actin-myosin filament sliding (GO:0033275)2.81576709
61muscle filament sliding (GO:0030049)2.81576709
62mesenchymal-epithelial cell signaling (GO:0060638)2.80282644
63IMP biosynthetic process (GO:0006188)2.79765139
64heart process (GO:0003015)2.78981790
65heart contraction (GO:0060047)2.78981790
66mesenchyme development (GO:0060485)2.78493436
67mitotic metaphase plate congression (GO:0007080)2.75682947
68oxidative phosphorylation (GO:0006119)2.75408548
69establishment of apical/basal cell polarity (GO:0035089)2.74077151
70kidney mesenchyme development (GO:0072074)2.73813215
71muscle tissue morphogenesis (GO:0060415)2.73620349
72DNA deamination (GO:0045006)2.72608233
73negative regulation of potassium ion transmembrane transport (GO:1901380)2.71760112
74positive regulation of smoothened signaling pathway (GO:0045880)2.69438162
75ribosomal small subunit assembly (GO:0000028)2.69043715
76trophectodermal cell differentiation (GO:0001829)2.67690205
77positive regulation of cardiac muscle cell proliferation (GO:0060045)2.67552649
78epithelial cell-cell adhesion (GO:0090136)2.67266979
79mitotic nuclear envelope disassembly (GO:0007077)2.66445512
80glomerular visceral epithelial cell development (GO:0072015)2.64889539
81tooth mineralization (GO:0034505)2.64727775
82regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64067544
83negative regulation of cardiac muscle tissue development (GO:0055026)2.61375679
84regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.61318197
85trabecula formation (GO:0060343)2.61275903
86fatty acid transmembrane transport (GO:1902001)2.59590632
87transcription from mitochondrial promoter (GO:0006390)2.59311844
88maturation of SSU-rRNA (GO:0030490)2.58762510
89retina vasculature morphogenesis in camera-type eye (GO:0061299)2.58744439
90substrate adhesion-dependent cell spreading (GO:0034446)2.57695690
91lymphangiogenesis (GO:0001946)2.57243394
92IMP metabolic process (GO:0046040)2.57146120
93actomyosin structure organization (GO:0031032)2.57080056
94regulation of apoptotic cell clearance (GO:2000425)2.55835125
95regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.55519283
96regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.55280147
97mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.53613679
98establishment or maintenance of monopolar cell polarity (GO:0061339)2.53369465
99establishment of monopolar cell polarity (GO:0061162)2.53369465
100establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.52237515
101negative regulation of cell fate specification (GO:0009996)2.52043806
102regulation of tight junction assembly (GO:2000810)2.50091769
103positive regulation of endothelial cell apoptotic process (GO:2000353)2.49911447
104negative regulation of chondrocyte differentiation (GO:0032331)2.48381871
105cochlea morphogenesis (GO:0090103)2.48114505
106cell-substrate junction assembly (GO:0007044)2.46493474
107regulation of cardiac muscle cell proliferation (GO:0060043)2.46172384
108gap junction assembly (GO:0016264)2.44760195
109protein localization to kinetochore (GO:0034501)2.44733002
110regulation of non-canonical Wnt signaling pathway (GO:2000050)2.44365983
111cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.44295817
112negative regulation of heart growth (GO:0061117)2.44289387
113negative regulation of cardiac muscle tissue growth (GO:0055022)2.44289387
114cardiac muscle contraction (GO:0060048)2.43430264
115pre-miRNA processing (GO:0031054)2.42989397
116negative regulation of smooth muscle cell migration (GO:0014912)2.42978211
117ribosome assembly (GO:0042255)2.42214507
118nuclear pore organization (GO:0006999)2.41831451
119regulation of transforming growth factor beta2 production (GO:0032909)2.40890221
120metaphase plate congression (GO:0051310)2.40830873
121nuclear envelope disassembly (GO:0051081)2.40355654
122membrane disassembly (GO:0030397)2.40355654
123regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.39807658
124polarized epithelial cell differentiation (GO:0030859)2.39328428
125regulation of cardiac muscle tissue development (GO:0055024)2.38434350
126sequestering of extracellular ligand from receptor (GO:0035581)2.37626987
127ventricular cardiac muscle cell action potential (GO:0086005)2.37242480
128apoptotic process involved in morphogenesis (GO:0060561)2.36736067
129negative regulation of striated muscle cell apoptotic process (GO:0010664)2.36010877
130ribosome biogenesis (GO:0042254)2.35401776
131cardiac muscle hypertrophy (GO:0003300)2.34244468
132actin-mediated cell contraction (GO:0070252)2.33131178
133negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.32098671
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.31584031
135DNA replication initiation (GO:0006270)2.31343631
136pteridine-containing compound biosynthetic process (GO:0042559)2.30944022
137regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.30259430
138venous blood vessel morphogenesis (GO:0048845)2.29431750
139rRNA modification (GO:0000154)2.29105976
1402-oxoglutarate metabolic process (GO:0006103)2.28078334
141cardiac right ventricle morphogenesis (GO:0003215)2.26242025
142heterochromatin organization (GO:0070828)2.26065471
143basement membrane organization (GO:0071711)2.25442534
144folic acid metabolic process (GO:0046655)2.24615193
145negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.23870481
146translational termination (GO:0006415)2.23834361
147viral transcription (GO:0019083)2.23156329
148regulation of spindle organization (GO:0090224)2.22485272
149mitochondrial DNA metabolic process (GO:0032042)2.22300047
150tricarboxylic acid metabolic process (GO:0072350)2.21148206
151translational initiation (GO:0006413)2.19808406
152nodal signaling pathway (GO:0038092)2.18791317
153notochord development (GO:0030903)2.18163881
154negative regulation of fatty acid biosynthetic process (GO:0045717)2.17602339
155regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.16836131
156regulation of gene silencing (GO:0060968)2.16542390
157endothelial tube morphogenesis (GO:0061154)2.15524318
158morphogenesis of an endothelium (GO:0003159)2.15524318
159striated muscle hypertrophy (GO:0014897)2.14625923
160adult heart development (GO:0007512)2.13670147
161DNA replication checkpoint (GO:0000076)2.13225334
162translational elongation (GO:0006414)2.12299823
163vascular endothelial growth factor signaling pathway (GO:0038084)2.10561742
164histone H4-K12 acetylation (GO:0043983)2.10058660
165anterior/posterior axis specification, embryo (GO:0008595)2.09442020
166outflow tract septum morphogenesis (GO:0003148)2.09103405
167ribonucleoprotein complex biogenesis (GO:0022613)2.08559948
168DNA strand elongation involved in DNA replication (GO:0006271)2.08000205
169regulation of mitotic spindle organization (GO:0060236)2.07392229
170* positive regulation of SMAD protein import into nucleus (GO:0060391)2.07337062
171nuclear pore complex assembly (GO:0051292)2.06765300
172DNA replication-dependent nucleosome organization (GO:0034723)2.06379187
173DNA replication-dependent nucleosome assembly (GO:0006335)2.06379187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.23338652
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.76674011
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.48958000
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.42165885
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03314947
6* PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.66073406
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.45478493
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35730023
9* EP300_21415370_ChIP-Seq_HL-1_Mouse2.34393515
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30879705
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.26385288
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.25040891
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21119680
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.20609485
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.20609485
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.20609485
17STAT3_1855785_ChIP-Seq_MESCs_Mouse2.19284920
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15745052
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15281628
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.11012375
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.98251857
22* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97257753
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.95631411
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94963803
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.89223853
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.85573240
27* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84613702
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82624016
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80979525
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78815298
31* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77414878
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.76110768
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.75157587
34* ISL1_27105846_Chip-Seq_CPCs_Mouse1.73840733
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71694647
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.69388388
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.68207767
38* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67550065
39* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64745834
40ZNF263_19887448_ChIP-Seq_K562_Human1.64629751
41* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.64290036
42AR_21909140_ChIP-Seq_LNCAP_Human1.62883939
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60864928
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.60563790
45XRN2_22483619_ChIP-Seq_HELA_Human1.60374167
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59036364
47NFIB_24661679_ChIP-Seq_LUNG_Mouse1.58517221
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.58389306
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57667872
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.57202527
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54358536
52MYC_22102868_ChIP-Seq_BL_Human1.53186584
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50101881
54* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.48796269
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44492603
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43770403
57* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43530595
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41425562
59GABP_17652178_ChIP-ChIP_JURKAT_Human1.40436104
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39340089
61CLOCK_20551151_ChIP-Seq_293T_Human1.38292367
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37866786
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37822752
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37569829
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37462613
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37196186
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35544645
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34816896
69* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33586100
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33290181
71* NANOG_16153702_ChIP-ChIP_HESCs_Human1.33104977
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32381046
73RACK7_27058665_Chip-Seq_MCF-7_Human1.31896882
74SOX2_18692474_ChIP-Seq_MEFs_Mouse1.31577849
75TBX3_20139965_ChIP-Seq_ESCs_Mouse1.30484989
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30157334
77* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.30148986
78TBX20_22080862_ChIP-Seq_HEART_Mouse1.30007708
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.30007708
80TBX3_20139965_ChIP-Seq_MESCs_Mouse1.28880357
81DCP1A_22483619_ChIP-Seq_HELA_Human1.28797197
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28336950
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28098596
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28079051
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27602769
86NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.27539431
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26854545
88GABP_19822575_ChIP-Seq_HepG2_Human1.26700916
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26291193
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25611119
91SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.24691321
92TCF3_18692474_ChIP-Seq_MESCs_Mouse1.24247319
93* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24111587
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23800340
95TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.23387980
96RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22845677
97EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22845677
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.22437945
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22029692
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19158438
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19153509
102NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17948962
103NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17756035
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17720974
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17646211
106RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17264502
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17014451
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16801474
109* LXR_22158963_ChIP-Seq_LIVER_Mouse1.16331220
110* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16270073
111NANOG_21062744_ChIP-ChIP_HESCs_Human1.15633716
112VDR_23849224_ChIP-Seq_CD4+_Human1.15063207
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14940137
114E2F1_21310950_ChIP-Seq_MCF-7_Human1.14818211
115ATF3_27146783_Chip-Seq_COLON_Human1.14802745
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14539067
117TP63_17297297_ChIP-ChIP_HaCaT_Human1.14158468
118MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14135603
119TP63_19390658_ChIP-ChIP_HaCaT_Human1.13975303
120OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13373074
121TFEB_21752829_ChIP-Seq_HELA_Human1.12895934
122* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12481991
123FOXP3_21729870_ChIP-Seq_TREG_Human1.12009842
124* RXR_22158963_ChIP-Seq_LIVER_Mouse1.11454480
125CIITA_25753668_ChIP-Seq_RAJI_Human1.10527488
126* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09365930
127TTF2_22483619_ChIP-Seq_HELA_Human1.09078495
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08592812
129* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08470385
130BRD4_25478319_ChIP-Seq_HGPS_Human1.07971748
131* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07942950
132SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07576276
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07491218
134SRF_21415370_ChIP-Seq_HL-1_Mouse1.05697656
135RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05560671
136TP53_20018659_ChIP-ChIP_R1E_Mouse1.04878768
137* SA1_22415368_ChIP-Seq_MEFs_Mouse1.04708363
138PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04401572
139EED_16625203_ChIP-ChIP_MESCs_Mouse1.04108348
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04101592
141PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03951328
142NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03870707
143NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02665261
144GATA4_21415370_ChIP-Seq_HL-1_Mouse1.02128343
145STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02113106
146RING1B_27294783_Chip-Seq_NPCs_Mouse1.01977484
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01733428
148UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01619936
149EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01434095
150NOTCH1_21737748_ChIP-Seq_TLL_Human1.00016657
151GATA1_26923725_Chip-Seq_HPCs_Mouse0.99887094
152EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99732326
153* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97975493
154ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96021355
155DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95783542
156YY1_21170310_ChIP-Seq_MESCs_Mouse0.94199697
157STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93827605
158KDM2B_26808549_Chip-Seq_K562_Human0.93649013
159CJUN_26792858_Chip-Seq_BT549_Human0.93309844
160KDM5A_27292631_Chip-Seq_BREAST_Human0.93279117
161* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93072863
162SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91928912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.05844326
2MP0004084_abnormal_cardiac_muscle3.81190233
3MP0002254_reproductive_system_inflammat3.61550459
4MP0005503_abnormal_tendon_morphology3.28790771
5MP0005275_abnormal_skin_tensile2.72492957
6MP0002837_dystrophic_cardiac_calcinosis2.55637814
7MP0009384_cardiac_valve_regurgitation2.46546391
8MP0005330_cardiomyopathy2.34080029
9MP0003567_abnormal_fetal_cardiomyocyte2.28810352
10MP0003828_pulmonary_edema2.26958047
11MP0010368_abnormal_lymphatic_system2.25097465
12MP0004957_abnormal_blastocyst_morpholog2.19478653
13MP0004036_abnormal_muscle_relaxation2.18723502
14MP0003693_abnormal_embryo_hatching2.18108743
15MP0001958_emphysema2.08314770
16MP0004215_abnormal_myocardial_fiber2.05536553
17MP0003646_muscle_fatigue2.04993979
18MP0010630_abnormal_cardiac_muscle2.01983312
19MP0005257_abnormal_intraocular_pressure1.94205504
20MP0000462_abnormal_digestive_system1.92247283
21MP0002108_abnormal_muscle_morphology1.77557263
22MP0000750_abnormal_muscle_regeneration1.76333738
23MP0006138_congestive_heart_failure1.75523200
24MP0008775_abnormal_heart_ventricle1.74419165
25MP0005385_cardiovascular_system_phenoty1.74372027
26MP0001544_abnormal_cardiovascular_syste1.74372027
27MP0003566_abnormal_cell_adhesion1.70453920
28MP0010352_gastrointestinal_tract_polyps1.69865406
29MP0003942_abnormal_urinary_system1.64719507
30MP0002972_abnormal_cardiac_muscle1.63031420
31MP0003221_abnormal_cardiomyocyte_apopto1.62095673
32MP0003984_embryonic_growth_retardation1.61376254
33MP0003806_abnormal_nucleotide_metabolis1.60671556
34MP0002088_abnormal_embryonic_growth/wei1.59587545
35MP0005508_abnormal_skeleton_morphology1.59104210
36MP0003941_abnormal_skin_development1.58890266
37MP0003077_abnormal_cell_cycle1.57912142
38MP0000049_abnormal_middle_ear1.57845089
39MP0001672_abnormal_embryogenesis/_devel1.56171471
40MP0005380_embryogenesis_phenotype1.56171471
41MP0004272_abnormal_basement_membrane1.55307954
42MP0002127_abnormal_cardiovascular_syste1.54949508
43MP0004087_abnormal_muscle_fiber1.54672347
44MP0003705_abnormal_hypodermis_morpholog1.47857973
45MP0000751_myopathy1.45047564
46MP0003111_abnormal_nucleus_morphology1.43506399
47MP0003937_abnormal_limbs/digits/tail_de1.43175946
48MP0001730_embryonic_growth_arrest1.40023631
49MP0002697_abnormal_eye_size1.39374184
50MP0003123_paternal_imprinting1.37244245
51MP0000749_muscle_degeneration1.34689173
52MP0000534_abnormal_ureter_morphology1.34519981
53MP0002269_muscular_atrophy1.34333500
54MP0001299_abnormal_eye_distance/1.34155053
55MP0002086_abnormal_extraembryonic_tissu1.31580406
56MP0009250_abnormal_appendicular_skeleto1.30003688
57MP0001697_abnormal_embryo_size1.28449954
58MP0006292_abnormal_olfactory_placode1.25028623
59MP0009379_abnormal_foot_pigmentation1.24344405
60MP0000566_synostosis1.23879068
61MP0000428_abnormal_craniofacial_morphol1.23313954
62MP0002295_abnormal_pulmonary_circulatio1.23222112
63MP0001879_abnormal_lymphatic_vessel1.22079838
64MP0002877_abnormal_melanocyte_morpholog1.21962619
65MP0000762_abnormal_tongue_morphology1.21905558
66MP0010094_abnormal_chromosome_stability1.21892929
67MP0008057_abnormal_DNA_replication1.20087348
68MP0000266_abnormal_heart_morphology1.20034867
69MP0008007_abnormal_cellular_replicative1.18776468
70MP0003137_abnormal_impulse_conducting1.17664578
71MP0002249_abnormal_larynx_morphology1.17376804
72MP0002106_abnormal_muscle_physiology1.16035161
73MP0005620_abnormal_muscle_contractility1.15735409
74MP0003119_abnormal_digestive_system1.15672272
75MP0005623_abnormal_meninges_morphology1.15016560
76MP0001849_ear_inflammation1.14763330
77MP0005670_abnormal_white_adipose1.13728381
78MP0003283_abnormal_digestive_organ1.12850236
79MP0002084_abnormal_developmental_patter1.11802494
80MP0004197_abnormal_fetal_growth/weight/1.11142518
81MP0002085_abnormal_embryonic_tissue1.11140784
82MP0005377_hearing/vestibular/ear_phenot1.10511906
83MP0003878_abnormal_ear_physiology1.10511906
84MP0003385_abnormal_body_wall1.09543242
85MP0004264_abnormal_extraembryonic_tissu1.09144650
86MP0000013_abnormal_adipose_tissue1.08993402
87MP0005666_abnormal_adipose_tissue1.08648752
88MP0006036_abnormal_mitochondrial_physio1.06731206
89MP0002080_prenatal_lethality1.06074569
90MP0008932_abnormal_embryonic_tissue1.03397753
91MP0005595_abnormal_vascular_smooth1.03375031
92MP0000432_abnormal_head_morphology1.03232372
93MP0010030_abnormal_orbit_morphology1.02275821
94MP0000350_abnormal_cell_proliferation1.02184839
95MP0009278_abnormal_bone_marrow1.01762342
96MP0005023_abnormal_wound_healing1.01481628
97MP0002925_abnormal_cardiovascular_devel1.01457477
98MP0005367_renal/urinary_system_phenotyp0.99582916
99MP0000516_abnormal_urinary_system0.99582916
100MP0002089_abnormal_postnatal_growth/wei0.99514441
101MP0004858_abnormal_nervous_system0.98966426
102MP0000343_altered_response_to0.98073871
103MP0003186_abnormal_redox_activity0.96693654
104MP0003115_abnormal_respiratory_system0.95556371
105MP0003279_aneurysm0.94985635
106MP0004133_heterotaxia0.93909516
107MP0001293_anophthalmia0.93489316
108MP0000003_abnormal_adipose_tissue0.93332164
109MP0001661_extended_life_span0.93227890
110MP0002233_abnormal_nose_morphology0.92528638
111MP0004130_abnormal_muscle_cell0.92226890
112MP0003935_abnormal_craniofacial_develop0.90816667
113MP0000767_abnormal_smooth_muscle0.90811531
114MP0002060_abnormal_skin_morphology0.90347596
115MP0001542_abnormal_bone_strength0.89942429
116MP0002128_abnormal_blood_circulation0.89286903
117MP0009703_decreased_birth_body0.88507182
118MP0010386_abnormal_urinary_bladder0.87250050
119MP0004233_abnormal_muscle_weight0.86259282
120MP0005369_muscle_phenotype0.85785375
121MP0002111_abnormal_tail_morphology0.85396736
122MP0000678_abnormal_parathyroid_gland0.84728549
123MP0004484_altered_response_of0.83962742
124MP0009840_abnormal_foam_cell0.83054397
125MP0002796_impaired_skin_barrier0.82881365
126MP0001286_abnormal_eye_development0.82309562
127MP0003755_abnormal_palate_morphology0.80827072
128MP0001545_abnormal_hematopoietic_system0.80745605
129MP0005397_hematopoietic_system_phenotyp0.80745605
130MP0005266_abnormal_metabolism0.80242047
131MP0001614_abnormal_blood_vessel0.80230029
132MP0002116_abnormal_craniofacial_bone0.80016604
133MP0004808_abnormal_hematopoietic_stem0.79719112
134MP0004185_abnormal_adipocyte_glucose0.79478688
135MP0003136_yellow_coat_color0.79181681
136MP0002396_abnormal_hematopoietic_system0.79114998
137MP0005076_abnormal_cell_differentiation0.78475057
138MP0002332_abnormal_exercise_endurance0.78446865
139MP0005319_abnormal_enzyme/_coenzyme0.78426547
140MP0008058_abnormal_DNA_repair0.77259555
141MP0004085_abnormal_heartbeat0.76223221
142MP0000537_abnormal_urethra_morphology0.75393739
143MP0000313_abnormal_cell_death0.72852521
144MP0009643_abnormal_urine_homeostasis0.72747687
145MP0002138_abnormal_hepatobiliary_system0.72433696
146MP0003890_abnormal_embryonic-extraembry0.71050235
147MP0006054_spinal_hemorrhage0.71012077
148MP0005375_adipose_tissue_phenotype0.70852590
149MP0000490_abnormal_crypts_of0.67831381
150MP0009672_abnormal_birth_weight0.67708374
151MP0003950_abnormal_plasma_membrane0.67162565
152MP0009053_abnormal_anal_canal0.66386709

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)5.15506044
2Ventricular tachycardia (HP:0004756)5.06717323
3Sudden death (HP:0001699)4.76170096
4Premature rupture of membranes (HP:0001788)4.50075719
5Broad metatarsal (HP:0001783)4.45155086
6Right ventricular cardiomyopathy (HP:0011663)3.99365643
7Aortic dissection (HP:0002647)3.96641330
8Abnormality of the left ventricular outflow tract (HP:0011103)3.95690884
9Subaortic stenosis (HP:0001682)3.95690884
10Shallow orbits (HP:0000586)3.85777732
11Lipoatrophy (HP:0100578)3.80349234
12Muscle fiber splitting (HP:0003555)3.52158877
13Hypoglycemic coma (HP:0001325)3.48963065
14Atrial fibrillation (HP:0005110)3.43819848
15Multiple enchondromatosis (HP:0005701)3.34598705
16Partial duplication of thumb phalanx (HP:0009944)3.26746043
17Palpitations (HP:0001962)3.26209275
18Supraventricular arrhythmia (HP:0005115)3.20236960
19Partial duplication of the phalanx of hand (HP:0009999)3.18160478
20Primary atrial arrhythmia (HP:0001692)3.17916992
21Supraventricular tachycardia (HP:0004755)3.15924793
22Coronal craniosynostosis (HP:0004440)3.15548737
23Choanal stenosis (HP:0000452)3.01581164
24Type 1 muscle fiber predominance (HP:0003803)3.01062941
25Dilated cardiomyopathy (HP:0001644)3.00342956
26Myoglobinuria (HP:0002913)2.94716960
27Atrioventricular block (HP:0001678)2.93742572
28Vascular tortuosity (HP:0004948)2.90642763
29Exercise-induced muscle cramps (HP:0003710)2.88019805
30Soft skin (HP:0000977)2.85571316
31Bronchomalacia (HP:0002780)2.82760249
32Asymmetric septal hypertrophy (HP:0001670)2.77583012
33Hyperglycinuria (HP:0003108)2.66081317
34Neonatal short-limb short stature (HP:0008921)2.65311448
35Spinal rigidity (HP:0003306)2.63936283
36Cervical subluxation (HP:0003308)2.60600096
37Rhabdomyolysis (HP:0003201)2.56931153
38Syncope (HP:0001279)2.53917472
39Progressive muscle weakness (HP:0003323)2.53791607
40Increased connective tissue (HP:0009025)2.50678375
41Mitral valve prolapse (HP:0001634)2.49152949
42Calf muscle hypertrophy (HP:0008981)2.47148769
43Persistence of primary teeth (HP:0006335)2.45633315
44Selective tooth agenesis (HP:0001592)2.42355969
45Arterial tortuosity (HP:0005116)2.41828421
46Abnormality of dentin (HP:0010299)2.41817726
47Short hallux (HP:0010109)2.41671790
48Ventricular arrhythmia (HP:0004308)2.40463306
49Bundle branch block (HP:0011710)2.39871266
50Hyperinsulinemic hypoglycemia (HP:0000825)2.38872006
51Heart block (HP:0012722)2.38562695
52Ulnar bowing (HP:0003031)2.38394195
53Turricephaly (HP:0000262)2.37358295
54Ragged-red muscle fibers (HP:0003200)2.35961182
55Nausea (HP:0002018)2.33687289
56Dicarboxylic aciduria (HP:0003215)2.33685395
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33685395
58Biconcave vertebral bodies (HP:0004586)2.33485651
59Ankle contracture (HP:0006466)2.33463088
60Generalized aminoaciduria (HP:0002909)2.29371637
61Bladder diverticulum (HP:0000015)2.28445492
62Ependymoma (HP:0002888)2.27856441
63Wide anterior fontanel (HP:0000260)2.26577478
64Wormian bones (HP:0002645)2.26411555
65Ectopia lentis (HP:0001083)2.25754477
66Abnormal atrioventricular conduction (HP:0005150)2.22964534
67Esophageal varix (HP:0002040)2.20767352
68Neonatal death (HP:0003811)2.15661430
69Increased variability in muscle fiber diameter (HP:0003557)2.14173664
70Aplasia/Hypoplasia of the hallux (HP:0008362)2.13519653
71Abnormality of fatty-acid metabolism (HP:0004359)2.13377621
72Blue sclerae (HP:0000592)2.12881579
73Broad long bones (HP:0005622)2.12598378
74Colon cancer (HP:0003003)2.11951940
75Broad thumb (HP:0011304)2.11676272
76Abnormality of the lacrimal duct (HP:0011481)2.10276914
77Ketoacidosis (HP:0001993)2.09078867
78Abnormality of the calf musculature (HP:0001430)2.07941095
79Preaxial foot polydactyly (HP:0001841)2.07074662
80Hyporeflexia of lower limbs (HP:0002600)2.06576819
81Shawl scrotum (HP:0000049)2.06017527
82Septo-optic dysplasia (HP:0100842)2.05289049
83Hyperglycemia (HP:0003074)2.05013447
84Proximal tubulopathy (HP:0000114)2.04869371
85Polycythemia (HP:0001901)2.04634467
86Duplication of thumb phalanx (HP:0009942)2.03656939
87Natal tooth (HP:0000695)2.00956597
88Protrusio acetabuli (HP:0003179)1.99474835
89Morphological abnormality of the middle ear (HP:0008609)1.98609887
90Follicular hyperkeratosis (HP:0007502)1.96956526
91Joint laxity (HP:0001388)1.95563285
92Lymphangioma (HP:0100764)1.94150451
93Abnormality of the middle phalanges of the toes (HP:0010183)1.93685460
94Aplasia/hypoplasia of the humerus (HP:0006507)1.92664344
95Mildly elevated creatine phosphokinase (HP:0008180)1.92617088
96Abnormality of the nasolacrimal system (HP:0000614)1.92564639
97Aortic regurgitation (HP:0001659)1.92085271
98Pancreatic islet-cell hyperplasia (HP:0004510)1.91958233
99Breast hypoplasia (HP:0003187)1.91764143
100Aneurysm (HP:0002617)1.90557141
101Fragile skin (HP:0001030)1.90406873
102Hepatic necrosis (HP:0002605)1.89949704
103Rectal prolapse (HP:0002035)1.89373497
104Advanced eruption of teeth (HP:0006288)1.89216717
105Genu recurvatum (HP:0002816)1.88970606
106Broad phalanx (HP:0006009)1.88527158
107Missing ribs (HP:0000921)1.88341004
108Hypoventilation (HP:0002791)1.87562770
109Difficulty climbing stairs (HP:0003551)1.87389846
110Maternal diabetes (HP:0009800)1.87291862
111Overgrowth (HP:0001548)1.86583560
112Abnormality of glycine metabolism (HP:0010895)1.86379035
113Abnormality of serine family amino acid metabolism (HP:0010894)1.86379035
114Atrophic scars (HP:0001075)1.85674342
115Muscle hypertrophy of the lower extremities (HP:0008968)1.85155589
116Hyperammonemia (HP:0001987)1.83974996
117Broad finger (HP:0001500)1.83468925
118Testicular atrophy (HP:0000029)1.83358693
119Disproportionate tall stature (HP:0001519)1.82235248
120Broad phalanges of the hand (HP:0009768)1.80572192
121Gout (HP:0001997)1.80349964
122Delayed cranial suture closure (HP:0000270)1.80338808
123Distal lower limb muscle weakness (HP:0009053)1.79207715
124Broad toe (HP:0001837)1.79196497
125Abnormal cartilage morphology (HP:0002763)1.78498034
126Reticulocytopenia (HP:0001896)1.78485744
127Mitral regurgitation (HP:0001653)1.78396188
128Areflexia of lower limbs (HP:0002522)1.78108071
129Late onset (HP:0003584)1.77087499
130Bowel diverticulosis (HP:0005222)1.76840548
131Hip contracture (HP:0003273)1.76775263
132Arnold-Chiari malformation (HP:0002308)1.76415026
133Short humerus (HP:0005792)1.76390051
134Hyperglycinemia (HP:0002154)1.75958102
135Hematochezia (HP:0002573)1.74744324
136Absent eyelashes (HP:0000561)1.73938675
137Limited hip movement (HP:0008800)1.72659369
138EMG: myopathic abnormalities (HP:0003458)1.72586898
139Mesangial abnormality (HP:0001966)1.72047924
140Bicornuate uterus (HP:0000813)1.71859545
141Angiofibromas (HP:0010615)1.71642361
142Adenoma sebaceum (HP:0009720)1.71642361
143Neoplasm of the rectum (HP:0100743)1.71454976
144Patent foramen ovale (HP:0001655)1.70784569
145Broad hallux (HP:0010055)1.70543705
146Palmoplantar keratoderma (HP:0000982)1.70028586
147Insulin resistance (HP:0000855)1.69589079
148Generalized amyotrophy (HP:0003700)1.68611890
149Prolonged QT interval (HP:0001657)1.68339136
150Camptodactyly of toe (HP:0001836)1.68285949
151Nasolacrimal duct obstruction (HP:0000579)1.68075172
152Abnormal delivery (HP:0001787)1.67718684
153Abnormality of skeletal muscle fiber size (HP:0012084)1.67409330
154Abnormality of the acetabulum (HP:0003170)1.66913041
155Carpal bone hypoplasia (HP:0001498)1.66329790
156Premature skin wrinkling (HP:0100678)1.65688643
157Dilatation of the ascending aorta (HP:0005111)1.65630559
158Pulmonary artery stenosis (HP:0004415)1.64133351
159Hemangiomatosis (HP:0007461)1.63669363
160Ketosis (HP:0001946)1.63353979
161Cerebral aneurysm (HP:0004944)1.63090695
162Ovarian neoplasm (HP:0100615)1.61652621
163Aplastic anemia (HP:0001915)1.61615775
164Trismus (HP:0000211)1.61438865
165Aplasia involving bones of the upper limbs (HP:0009823)1.60900926
166Aplasia of the phalanges of the hand (HP:0009802)1.60900926
167Aplasia involving bones of the extremities (HP:0009825)1.60900926
168Midface retrusion (HP:0011800)1.59567432
169Vertebral arch anomaly (HP:0008438)1.59475235
170Vaginal fistula (HP:0004320)1.59276052
171Hyperextensible skin (HP:0000974)1.58934549
172Ventricular fibrillation (HP:0001663)1.57747416
173Aortic valve stenosis (HP:0001650)1.57666775
174Myelomeningocele (HP:0002475)1.57570576
175Rib fusion (HP:0000902)1.57444428
176Nonimmune hydrops fetalis (HP:0001790)1.56857264
177Transposition of the great arteries (HP:0001669)1.56289342
178Abnormal connection of the cardiac segments (HP:0011545)1.56289342
179Abnormal ventriculo-arterial connection (HP:0011563)1.56289342
180Synostosis involving the elbow (HP:0003938)1.54849669
181Humeroradial synostosis (HP:0003041)1.54849669
182Delayed CNS myelination (HP:0002188)1.54817716
183Abnormality of the salivary glands (HP:0010286)1.54435513
184Exercise-induced myalgia (HP:0003738)1.54251855
185Abnormal hemoglobin (HP:0011902)1.53402695
186Fused cervical vertebrae (HP:0002949)1.52649573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK3.05862981
2TIE12.97190326
3EPHA22.78117450
4BCKDK2.68156754
5FLT32.61923242
6PKN22.61511563
7TTN2.47866977
8WEE12.38196795
9TAF12.21738379
10TGFBR12.15607345
11KDR2.14385280
12CDK122.10219752
13STK38L1.99892922
14DDR21.96674739
15NEK11.92155891
16NME21.83573549
17BUB11.78856988
18RPS6KB21.77580206
19TRIB31.70569033
20SMG11.65748340
21NEK21.60978125
22ACVR1B1.60418819
23LATS11.53441810
24OBSCN1.51531493
25TGFBR21.51053065
26TTK1.48554705
27PDK41.48056634
28PDK31.48056634
29ERN11.46327324
30STK241.43662858
31MAPKAPK31.40305172
32DMPK1.37227761
33PAK41.35859456
34CDK71.35248268
35MAP2K31.33670862
36VRK21.25629227
37FGFR21.24041861
38FGFR11.23488073
39LATS21.16923261
40CDC71.13696360
41BRSK21.12784448
42DYRK31.12482518
43ZAK1.09939336
44MAP3K31.06538778
45NTRK11.06281531
46ILK1.05182252
47RIPK11.04739521
48CAMK1G1.03825426
49RPS6KA41.03115868
50CAMK1D1.02560865
51CDK41.02313712
52MAPK151.01992921
53MAP3K101.00879083
54PASK1.00792892
55BMX1.00715951
56STK40.99824276
57MAP3K70.99726159
58PLK10.98494622
59AURKB0.95939938
60PDGFRA0.95032116
61RPS6KA20.94996490
62PDK20.94029482
63AKT30.93835759
64SIK10.88544009
65MTOR0.85997499
66PLK40.84124948
67PIK3CG0.82537033
68STK100.81656176
69STK30.81439558
70MAP3K80.80158107
71CAMK10.79990339
72PDGFRB0.75764425
73MAP2K20.75455208
74LRRK20.75421875
75ERBB40.73433574
76STK390.73117131
77EIF2AK10.73115980
78STK380.72437987
79LMTK20.71305099
80TNIK0.71009497
81ROCK10.68565339
82PRKD20.67314911
83PIM10.64970967
84EEF2K0.64279288
85MET0.64241826
86MAP3K110.63354314
87PAK20.63152916
88PTK60.62932053
89NEK90.62739073
90MELK0.61264892
91PRKG20.60959117
92MAP3K60.59581016
93DAPK30.57595830
94SRPK10.55393529
95PTK20.55356436
96AKT20.54520466
97MAPK70.54267185
98NME10.54231993
99NLK0.54192496
100FGFR40.53457161
101OXSR10.53298753
102PBK0.53177534
103SCYL20.52019207
104PINK10.51711056
105CDC42BPA0.51533533
106PRKCI0.49681493
107TYRO30.49499329
108CHEK20.49364363
109WNK10.48989125
110CDK60.48452102
111MATK0.48130540
112PRKD10.47693767
113MKNK20.46341213
114GSK3A0.46024599
115JAK30.45787700
116BRD40.45451231
117WNK40.45415742
118PRKAA20.44979126
119TSSK60.44878050
120MUSK0.43377052
121ATR0.42949575
122AURKA0.42166999
123TESK10.41549371
124ROCK20.41126812
125DYRK1B0.40178301
126MKNK10.40165521
127MAP3K50.40150356
128EPHB20.39303961
129PAK10.39170983
130GRK10.37613343
131RPS6KA60.36510619
132RPS6KL10.36413003
133RPS6KC10.36413003
134DYRK20.36171966
135INSRR0.35784897
136CDK80.35711773
137CHEK10.35605453
138PIK3CA0.35395744
139ICK0.34892062
140MARK20.34684234
141NUAK10.34373507
142KIT0.32698222

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.50130200
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.95184857
3DNA replication_Homo sapiens_hsa030302.42598558
4Mismatch repair_Homo sapiens_hsa034302.29344691
5Ribosome_Homo sapiens_hsa030102.14356680
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11065912
7RNA transport_Homo sapiens_hsa030132.01430161
8Protein digestion and absorption_Homo sapiens_hsa049741.96648827
9Carbon metabolism_Homo sapiens_hsa012001.94172037
10RNA polymerase_Homo sapiens_hsa030201.91374101
11Hedgehog signaling pathway_Homo sapiens_hsa043401.89799666
12Fatty acid degradation_Homo sapiens_hsa000711.86255950
13Base excision repair_Homo sapiens_hsa034101.75408135
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73619974
15Propanoate metabolism_Homo sapiens_hsa006401.72477743
16Spliceosome_Homo sapiens_hsa030401.70126806
17One carbon pool by folate_Homo sapiens_hsa006701.69503277
18Complement and coagulation cascades_Homo sapiens_hsa046101.67145110
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62652342
20Selenocompound metabolism_Homo sapiens_hsa004501.62475152
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.60250803
22Biosynthesis of amino acids_Homo sapiens_hsa012301.59139956
23Folate biosynthesis_Homo sapiens_hsa007901.56219557
24Cell cycle_Homo sapiens_hsa041101.54902107
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52084896
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.48155743
27Pyrimidine metabolism_Homo sapiens_hsa002401.45547905
28Proteasome_Homo sapiens_hsa030501.39495942
29Nucleotide excision repair_Homo sapiens_hsa034201.36559538
30Wnt signaling pathway_Homo sapiens_hsa043101.35349093
31Homologous recombination_Homo sapiens_hsa034401.31684567
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29330291
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.26633845
34Vitamin digestion and absorption_Homo sapiens_hsa049771.26224356
35Dilated cardiomyopathy_Homo sapiens_hsa054141.25739010
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.23413347
37RNA degradation_Homo sapiens_hsa030181.22682817
38Tyrosine metabolism_Homo sapiens_hsa003501.22205017
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.17182701
40Sulfur relay system_Homo sapiens_hsa041221.17170628
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.15622853
42Fatty acid metabolism_Homo sapiens_hsa012121.15385906
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12946638
44Adherens junction_Homo sapiens_hsa045201.12691074
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11993683
46p53 signaling pathway_Homo sapiens_hsa041151.11467214
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08605999
48Galactose metabolism_Homo sapiens_hsa000521.06365943
49Amoebiasis_Homo sapiens_hsa051461.05896573
50Cardiac muscle contraction_Homo sapiens_hsa042601.04959282
51Lysine degradation_Homo sapiens_hsa003101.04899724
52Retinol metabolism_Homo sapiens_hsa008301.04380567
53Thyroid cancer_Homo sapiens_hsa052161.03770680
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03411065
55Histidine metabolism_Homo sapiens_hsa003401.01077157
56Tryptophan metabolism_Homo sapiens_hsa003801.00099443
57PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99362141
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99150939
59Pyruvate metabolism_Homo sapiens_hsa006200.98290701
60Small cell lung cancer_Homo sapiens_hsa052220.98015147
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97632698
62Melanogenesis_Homo sapiens_hsa049160.97061192
63Fructose and mannose metabolism_Homo sapiens_hsa000510.96318805
64Pentose phosphate pathway_Homo sapiens_hsa000300.95122050
65Melanoma_Homo sapiens_hsa052180.95095162
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92156931
67Prostate cancer_Homo sapiens_hsa052150.90864071
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90669477
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89990677
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88169026
71mRNA surveillance pathway_Homo sapiens_hsa030150.86220455
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84281420
73Fat digestion and absorption_Homo sapiens_hsa049750.83933211
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83564603
75Basal transcription factors_Homo sapiens_hsa030220.80217182
76Hippo signaling pathway_Homo sapiens_hsa043900.78010419
77Glutathione metabolism_Homo sapiens_hsa004800.77394173
78Viral myocarditis_Homo sapiens_hsa054160.76341481
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.75570833
80Thyroid hormone synthesis_Homo sapiens_hsa049180.74775297
81Tight junction_Homo sapiens_hsa045300.74624589
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73059238
83Insulin resistance_Homo sapiens_hsa049310.72076261
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70198235
85Focal adhesion_Homo sapiens_hsa045100.69563841
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69090562
87TGF-beta signaling pathway_Homo sapiens_hsa043500.68903207
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.68757372
89ECM-receptor interaction_Homo sapiens_hsa045120.68280446
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.67599915
91PPAR signaling pathway_Homo sapiens_hsa033200.66943392
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66575401
93Purine metabolism_Homo sapiens_hsa002300.66393471
94HIF-1 signaling pathway_Homo sapiens_hsa040660.65902702
95Herpes simplex infection_Homo sapiens_hsa051680.65257095
96Notch signaling pathway_Homo sapiens_hsa043300.65217290
97Arginine and proline metabolism_Homo sapiens_hsa003300.64521184
98Bile secretion_Homo sapiens_hsa049760.63838207
99Bladder cancer_Homo sapiens_hsa052190.63393515
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63214491
101Parkinsons disease_Homo sapiens_hsa050120.62053515
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61917375
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60136000
104Fanconi anemia pathway_Homo sapiens_hsa034600.59516990
105Huntingtons disease_Homo sapiens_hsa050160.58870991
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57835018
107Legionellosis_Homo sapiens_hsa051340.57076042
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56603061
109Starch and sucrose metabolism_Homo sapiens_hsa005000.56602717
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56523051
111Arginine biosynthesis_Homo sapiens_hsa002200.56519721
112Peroxisome_Homo sapiens_hsa041460.56455328
113beta-Alanine metabolism_Homo sapiens_hsa004100.56418909
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56349953
115Basal cell carcinoma_Homo sapiens_hsa052170.54575702
116Renin-angiotensin system_Homo sapiens_hsa046140.54442519
117Arachidonic acid metabolism_Homo sapiens_hsa005900.53835915
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53193801
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49651607
120MicroRNAs in cancer_Homo sapiens_hsa052060.49532004
121Chemical carcinogenesis_Homo sapiens_hsa052040.49516786
122HTLV-I infection_Homo sapiens_hsa051660.49426387
123Rap1 signaling pathway_Homo sapiens_hsa040150.49397671
124Vitamin B6 metabolism_Homo sapiens_hsa007500.48513411
125AMPK signaling pathway_Homo sapiens_hsa041520.48344898
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48048261
127Glucagon signaling pathway_Homo sapiens_hsa049220.47317422
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.46143187
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45881009
130Axon guidance_Homo sapiens_hsa043600.45247379
131Epstein-Barr virus infection_Homo sapiens_hsa051690.44969217
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43906307
133Phenylalanine metabolism_Homo sapiens_hsa003600.42955013
134Proteoglycans in cancer_Homo sapiens_hsa052050.42172657
135Pathways in cancer_Homo sapiens_hsa052000.41869788
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41764356
137Acute myeloid leukemia_Homo sapiens_hsa052210.41459990
138Insulin signaling pathway_Homo sapiens_hsa049100.41406613
139Caffeine metabolism_Homo sapiens_hsa002320.40524713
140Gap junction_Homo sapiens_hsa045400.40405035
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.40143886

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