RBPMS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the RNA recognition motif (RRM)-containing protein family and is involved in the development and dedifferentiation of digestive smooth muscle cells. The encoded protein functions as a homodimer and indirectly inhibits the bone morphogenetic protein pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.91633242
2establishment of integrated proviral latency (GO:0075713)4.78314321
3regulation of gene silencing by RNA (GO:0060966)4.41283363
4regulation of posttranscriptional gene silencing (GO:0060147)4.41283363
5regulation of gene silencing by miRNA (GO:0060964)4.41283363
6L-serine metabolic process (GO:0006563)4.28187274
7nucleobase biosynthetic process (GO:0046112)4.12556165
8purine nucleobase biosynthetic process (GO:0009113)4.10919965
9folic acid-containing compound biosynthetic process (GO:0009396)4.10383219
10folic acid metabolic process (GO:0046655)4.02066408
11metaphase plate congression (GO:0051310)4.00488026
12histone exchange (GO:0043486)3.93525896
13regulation of histone H3-K9 methylation (GO:0051570)3.91999878
14ribosome assembly (GO:0042255)3.81829563
15DNA replication checkpoint (GO:0000076)3.77541672
16glycine metabolic process (GO:0006544)3.76791486
17protein localization to kinetochore (GO:0034501)3.73484392
18mitotic nuclear envelope disassembly (GO:0007077)3.73188074
19DNA replication-dependent nucleosome organization (GO:0034723)3.70486622
20DNA replication-dependent nucleosome assembly (GO:0006335)3.70486622
21DNA replication initiation (GO:0006270)3.69864870
22formation of translation preinitiation complex (GO:0001731)3.69701206
23ventricular cardiac muscle cell development (GO:0055015)3.62386758
24negative regulation of gene silencing (GO:0060969)3.58574973
25ribosome biogenesis (GO:0042254)3.54883565
26mitotic sister chromatid segregation (GO:0000070)3.54433281
27establishment of viral latency (GO:0019043)3.47609720
28regulation of spindle organization (GO:0090224)3.44806882
29nuclear envelope disassembly (GO:0051081)3.44216472
30membrane disassembly (GO:0030397)3.44216472
31DNA strand elongation involved in DNA replication (GO:0006271)3.43307171
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39511783
33establishment of chromosome localization (GO:0051303)3.39457625
34paraxial mesoderm development (GO:0048339)3.38462191
35protein complex localization (GO:0031503)3.37081495
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33536414
37regulation of helicase activity (GO:0051095)3.33451618
38maturation of 5.8S rRNA (GO:0000460)3.32059820
39mitotic chromosome condensation (GO:0007076)3.30591138
40serine family amino acid catabolic process (GO:0009071)3.27444141
41regulation of cell fate specification (GO:0042659)3.26923814
42protein localization to chromosome, centromeric region (GO:0071459)3.26465855
43DNA strand elongation (GO:0022616)3.23844876
44rRNA modification (GO:0000154)3.20273800
45DNA unwinding involved in DNA replication (GO:0006268)3.20080463
46regulation of DNA methylation (GO:0044030)3.18365450
47protein K6-linked ubiquitination (GO:0085020)3.15117367
48regulation of SMAD protein import into nucleus (GO:0060390)3.13173856
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10816015
50regulation of mitotic spindle checkpoint (GO:1903504)3.10816015
51positive regulation of chromosome segregation (GO:0051984)3.08169776
52somatic hypermutation of immunoglobulin genes (GO:0016446)3.07785663
53somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07785663
54serine family amino acid metabolic process (GO:0009069)3.07573728
55establishment of protein localization to mitochondrial membrane (GO:0090151)3.07131116
56chaperone-mediated protein transport (GO:0072321)3.06648150
57cellular protein complex localization (GO:0034629)3.04030428
58regulation of telomere maintenance via telomerase (GO:0032210)3.03830306
59pre-miRNA processing (GO:0031054)3.01798132
60regulation of mitotic spindle organization (GO:0060236)3.01289744
61L-alpha-amino acid transmembrane transport (GO:1902475)3.00910113
62serine family amino acid biosynthetic process (GO:0009070)3.00430445
63regulation of chromatin silencing (GO:0031935)3.00239091
64ATP-dependent chromatin remodeling (GO:0043044)2.99981861
65regulation of gene silencing (GO:0060968)2.99671568
66negative regulation of chromosome segregation (GO:0051985)2.99354496
67nuclear pore organization (GO:0006999)2.98656054
68lysine catabolic process (GO:0006554)2.98557576
69lysine metabolic process (GO:0006553)2.98557576
70protein neddylation (GO:0045116)2.96119379
71DNA deamination (GO:0045006)2.95210765
72lung-associated mesenchyme development (GO:0060484)2.94964476
73cell fate commitment involved in formation of primary germ layer (GO:0060795)2.92879089
74nuclear pore complex assembly (GO:0051292)2.92129608
75negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.92056887
76telomere maintenance via semi-conservative replication (GO:0032201)2.91968846
77attachment of spindle microtubules to kinetochore (GO:0008608)2.91736489
78negative regulation of histone methylation (GO:0031061)2.91442363
79chromatin assembly or disassembly (GO:0006333)2.90995463
80regulation of chromosome segregation (GO:0051983)2.89620511
81chromatin remodeling at centromere (GO:0031055)2.88509525
82spindle checkpoint (GO:0031577)2.88069388
83regulation of hippo signaling (GO:0035330)2.87861180
84mitochondrial DNA metabolic process (GO:0032042)2.87279638
85regulation of stem cell maintenance (GO:2000036)2.87271310
86regulation of cardioblast differentiation (GO:0051890)2.87233693
87DNA damage response, detection of DNA damage (GO:0042769)2.86006253
88bundle of His cell to Purkinje myocyte communication (GO:0086069)2.85933255
89CENP-A containing nucleosome assembly (GO:0034080)2.84798894
90negative regulation of mitotic sister chromatid separation (GO:2000816)2.84547508
91negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84547508
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84547508
93negative regulation of sister chromatid segregation (GO:0033046)2.84547508
94kinetochore assembly (GO:0051382)2.84113465
95IMP biosynthetic process (GO:0006188)2.83665884
96sister chromatid segregation (GO:0000819)2.82191709
97regulation of sister chromatid cohesion (GO:0007063)2.81969153
98transcription from mitochondrial promoter (GO:0006390)2.81847324
99regulation of double-strand break repair via homologous recombination (GO:0010569)2.81770650
100regulation of mitotic sister chromatid separation (GO:0010965)2.81715630
101regulation of mitotic sister chromatid segregation (GO:0033047)2.81715630
102regulation of sister chromatid segregation (GO:0033045)2.81715630
103negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81393087
104pteridine-containing compound biosynthetic process (GO:0042559)2.80799999
105folic acid-containing compound metabolic process (GO:0006760)2.80104583
106negative regulation of mitosis (GO:0045839)2.80053315
107negative regulation of androgen receptor signaling pathway (GO:0060766)2.79637444
108regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.79083891
109maturation of SSU-rRNA (GO:0030490)2.78770924
110tetrahydrofolate metabolic process (GO:0046653)2.78248722
111negative regulation of telomerase activity (GO:0051974)2.77884980
112mitotic spindle checkpoint (GO:0071174)2.77533051
113anterior/posterior axis specification, embryo (GO:0008595)2.76331208
114regulation of centrosome cycle (GO:0046605)2.75715013
115nuclear envelope organization (GO:0006998)2.74769427
116mitotic spindle assembly checkpoint (GO:0007094)2.74747747
117single strand break repair (GO:0000012)2.74551340
118ribonucleoprotein complex biogenesis (GO:0022613)2.73377235
119DNA replication-independent nucleosome organization (GO:0034724)2.73152697
120DNA replication-independent nucleosome assembly (GO:0006336)2.73152697
121proteasome assembly (GO:0043248)2.72807580
122histone arginine methylation (GO:0034969)2.72421484
123mitotic G2/M transition checkpoint (GO:0044818)2.71868831
124kinetochore organization (GO:0051383)2.71314035
125spliceosomal snRNP assembly (GO:0000387)2.71126908
126spindle assembly checkpoint (GO:0071173)2.70015072
127heterochromatin organization (GO:0070828)2.69656006
128notochord development (GO:0030903)2.69305219
129chromatin assembly (GO:0031497)2.67040924
130regulation of mitotic metaphase/anaphase transition (GO:0030071)2.66641406
131regulation of nuclear cell cycle DNA replication (GO:0033262)2.66199565
132protein localization to chromosome (GO:0034502)2.65841455
133mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.65573841
134regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.64610855
135positive regulation of SMAD protein import into nucleus (GO:0060391)2.64587534
136IMP metabolic process (GO:0046040)2.64091213
137maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63325365
138anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.63101468
139rRNA methylation (GO:0031167)2.63070762
140cysteine metabolic process (GO:0006534)2.62843843
141histone H2A monoubiquitination (GO:0035518)2.62813565
142telomere maintenance via telomere lengthening (GO:0010833)2.61547955
143telomere maintenance via recombination (GO:0000722)2.61367162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.16500482
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.99221065
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.76732569
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95720750
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.93815356
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90365285
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78444015
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68592479
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.68353759
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62672991
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53584730
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52412865
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.46369048
14NANOG_18555785_ChIP-Seq_MESCs_Mouse2.44826647
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40289637
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.37509501
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.37509501
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.37509501
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.32030319
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.31874781
21AR_21909140_ChIP-Seq_LNCAP_Human2.29505247
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.28946952
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26363134
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18899994
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13678640
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.09548651
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04044773
28NANOG_16153702_ChIP-ChIP_HESCs_Human2.01516352
29STAT3_1855785_ChIP-Seq_MESCs_Mouse2.00838677
30TCF3_18692474_ChIP-Seq_MEFs_Mouse2.00056704
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94915704
32NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.93044541
33XRN2_22483619_ChIP-Seq_HELA_Human1.92966841
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90085889
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88153652
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87857335
37SOX2_16153702_ChIP-ChIP_HESCs_Human1.80588826
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80160973
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.78152164
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.78062609
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68378564
42* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.65678109
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62767124
44GABP_19822575_ChIP-Seq_HepG2_Human1.61297806
45* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.60409420
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.54594956
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53844479
48DCP1A_22483619_ChIP-Seq_HELA_Human1.53397899
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.50441811
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.49519224
51SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.48943937
52VDR_23849224_ChIP-Seq_CD4+_Human1.48511712
53* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45590311
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43711021
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43248213
56NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.42454469
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.42159393
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.40853709
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40151486
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39872002
61TTF2_22483619_ChIP-Seq_HELA_Human1.37201641
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37006816
63NANOG_21062744_ChIP-ChIP_HESCs_Human1.36995294
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35682740
65* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.35479800
66FOXP3_21729870_ChIP-Seq_TREG_Human1.35470963
67KDM5A_27292631_Chip-Seq_BREAST_Human1.32587628
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31191755
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31173141
70* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30787043
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26269190
72SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25721989
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25336675
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25170776
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.25066085
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24791070
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24142426
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23371607
79POU5F1_16518401_ChIP-PET_MESCs_Mouse1.22612559
80PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22560924
81OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22534605
82RXR_22158963_ChIP-Seq_LIVER_Mouse1.21860061
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20235626
84MYC_18940864_ChIP-ChIP_HL60_Human1.20232704
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17759731
86* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17316252
87NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16771713
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16398597
89* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16337836
90* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15914532
91* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.15310001
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14650343
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13349057
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.12231577
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12100307
96ELK1_19687146_ChIP-ChIP_HELA_Human1.09570544
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09277305
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08890121
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07091270
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05254095
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04814511
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04036377
103KAP1_27257070_Chip-Seq_ESCs_Mouse1.03791289
104* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02783964
105CIITA_25753668_ChIP-Seq_RAJI_Human1.01532354
106MYC_22102868_ChIP-Seq_BL_Human1.01220315
107ZNF263_19887448_ChIP-Seq_K562_Human0.96929382
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.96277325
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94653758
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94177447
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92595538
112TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.92171807
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91701378
114EZH2_22144423_ChIP-Seq_EOC_Human0.91210336
115POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91099518
116TFEB_21752829_ChIP-Seq_HELA_Human0.90184264
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87549280
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87317794
119KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86924900
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84831688
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84416557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.43334210
2MP0002254_reproductive_system_inflammat3.89490026
3MP0004957_abnormal_blastocyst_morpholog3.80854545
4MP0003111_abnormal_nucleus_morphology3.71403135
5MP0003806_abnormal_nucleotide_metabolis3.65736417
6MP0010094_abnormal_chromosome_stability3.32252468
7MP0003077_abnormal_cell_cycle3.16231080
8MP0003718_maternal_effect3.08449233
9MP0008057_abnormal_DNA_replication2.68443876
10MP0002653_abnormal_ependyma_morphology2.46696608
11MP0005360_urolithiasis2.36070492
12MP0001730_embryonic_growth_arrest2.32042180
13MP0002837_dystrophic_cardiac_calcinosis2.31174275
14MP0003123_paternal_imprinting2.24478588
15MP0003646_muscle_fatigue2.22941033
16MP0002139_abnormal_hepatobiliary_system2.21768255
17MP0008932_abnormal_embryonic_tissue2.17527218
18MP0008058_abnormal_DNA_repair2.14241874
19MP0010030_abnormal_orbit_morphology2.13475496
20MP0004215_abnormal_myocardial_fiber2.12903052
21MP0003136_yellow_coat_color2.10286674
22MP0001672_abnormal_embryogenesis/_devel1.99392065
23MP0005380_embryogenesis_phenotype1.99392065
24MP0005451_abnormal_body_composition1.99184301
25MP0008877_abnormal_DNA_methylation1.89279423
26MP0005085_abnormal_gallbladder_physiolo1.87689163
27MP0000350_abnormal_cell_proliferation1.84376509
28MP0001697_abnormal_embryo_size1.80905914
29MP0004133_heterotaxia1.80759551
30MP0003984_embryonic_growth_retardation1.76787365
31MP0005365_abnormal_bile_salt1.76724629
32MP0002088_abnormal_embryonic_growth/wei1.73813743
33MP0000751_myopathy1.72778381
34MP0002085_abnormal_embryonic_tissue1.71568802
35MP0009840_abnormal_foam_cell1.68359096
36MP0003890_abnormal_embryonic-extraembry1.63928556
37MP0002084_abnormal_developmental_patter1.62781253
38MP0008007_abnormal_cellular_replicative1.59505061
39MP0010352_gastrointestinal_tract_polyps1.58524144
40MP0004036_abnormal_muscle_relaxation1.55185679
41MP0002086_abnormal_extraembryonic_tissu1.49059283
42MP0003119_abnormal_digestive_system1.47030020
43MP0002080_prenatal_lethality1.44748095
44MP0003137_abnormal_impulse_conducting1.40765605
45MP0005332_abnormal_amino_acid1.39504451
46MP0002972_abnormal_cardiac_muscle1.38857800
47MP0003567_abnormal_fetal_cardiomyocyte1.35061612
48MP0003186_abnormal_redox_activity1.34767412
49MP0002697_abnormal_eye_size1.34194587
50MP0006292_abnormal_olfactory_placode1.33593071
51MP0005395_other_phenotype1.33454348
52MP0000049_abnormal_middle_ear1.31560638
53MP0003786_premature_aging1.29602916
54MP0005385_cardiovascular_system_phenoty1.27834135
55MP0001544_abnormal_cardiovascular_syste1.27834135
56MP0006138_congestive_heart_failure1.27194004
57MP0008875_abnormal_xenobiotic_pharmacok1.22037705
58MP0003705_abnormal_hypodermis_morpholog1.22015311
59MP0002249_abnormal_larynx_morphology1.20009699
60MP0004084_abnormal_cardiac_muscle1.18976368
61MP0004197_abnormal_fetal_growth/weight/1.18710279
62MP0004264_abnormal_extraembryonic_tissu1.15119657
63MP0005266_abnormal_metabolism1.14331800
64MP0006036_abnormal_mitochondrial_physio1.13789415
65MP0002210_abnormal_sex_determination1.13269250
66MP0001293_anophthalmia1.13015003
67MP0008775_abnormal_heart_ventricle1.11921474
68MP0005670_abnormal_white_adipose1.11185379
69MP0003221_abnormal_cardiomyocyte_apopto1.10258759
70MP0001188_hyperpigmentation1.07410819
71MP0002269_muscular_atrophy1.07035759
72MP0004087_abnormal_muscle_fiber1.06428666
73MP0001145_abnormal_male_reproductive1.05845773
74MP0000579_abnormal_nail_morphology1.05594022
75MP0003315_abnormal_perineum_morphology1.04437913
76MP0004019_abnormal_vitamin_homeostasis1.04418844
77MP0009672_abnormal_birth_weight1.04004760
78MP0009053_abnormal_anal_canal1.03903653
79MP0001119_abnormal_female_reproductive1.03499267
80MP0002127_abnormal_cardiovascular_syste1.03270496
81MP0000653_abnormal_sex_gland1.02875748
82MP0008789_abnormal_olfactory_epithelium1.02757733
83MP0000428_abnormal_craniofacial_morphol1.02101838
84MP0002102_abnormal_ear_morphology1.01914565
85MP0002233_abnormal_nose_morphology0.99413591
86MP0005499_abnormal_olfactory_system0.98915558
87MP0005394_taste/olfaction_phenotype0.98915558
88MP0001929_abnormal_gametogenesis0.98500757
89MP0003699_abnormal_female_reproductive0.97809717
90MP0000750_abnormal_muscle_regeneration0.97706046
91MP0003941_abnormal_skin_development0.95991436
92MP0009697_abnormal_copulation0.95684848
93MP0000313_abnormal_cell_death0.95355567
94MP0010307_abnormal_tumor_latency0.93782472
95MP0006035_abnormal_mitochondrial_morpho0.93762786
96MP0002796_impaired_skin_barrier0.93455780
97MP0005620_abnormal_muscle_contractility0.92827544
98MP0003937_abnormal_limbs/digits/tail_de0.91615476
99MP0004185_abnormal_adipocyte_glucose0.90958113
100MP0009379_abnormal_foot_pigmentation0.89534556
101MP0004085_abnormal_heartbeat0.89025825
102MP0002019_abnormal_tumor_incidence0.88471185
103MP0002938_white_spotting0.87030794
104MP0003121_genomic_imprinting0.85519420
105MP0002332_abnormal_exercise_endurance0.84346552
106MP0002111_abnormal_tail_morphology0.83251680
107MP0003861_abnormal_nervous_system0.82258581
108MP0005330_cardiomyopathy0.82044918
109MP0004233_abnormal_muscle_weight0.81296723
110MP0002090_abnormal_vision0.80079374
111MP0004272_abnormal_basement_membrane0.79178361
112MP0000358_abnormal_cell_content/0.78993661
113MP0001661_extended_life_span0.78770343
114MP0001915_intracranial_hemorrhage0.78304192
115MP0001299_abnormal_eye_distance/0.77810009
116MP0001849_ear_inflammation0.77024962
117MP0000266_abnormal_heart_morphology0.76676362
118MP0005319_abnormal_enzyme/_coenzyme0.76345271
119MP0000537_abnormal_urethra_morphology0.76115580
120MP0005023_abnormal_wound_healing0.75043766
121MP0010368_abnormal_lymphatic_system0.74853693
122MP0005666_abnormal_adipose_tissue0.74538765
123MP0003283_abnormal_digestive_organ0.74330121
124MP0000598_abnormal_liver_morphology0.71602243
125MP0000566_synostosis0.70741954
126MP0010630_abnormal_cardiac_muscle0.69730886
127MP0002106_abnormal_muscle_physiology0.69352279
128MP0000609_abnormal_liver_physiology0.69086707
129MP0002736_abnormal_nociception_after0.68388527
130MP0003878_abnormal_ear_physiology0.68373643
131MP0005377_hearing/vestibular/ear_phenot0.68373643
132MP0000490_abnormal_crypts_of0.67615991
133MP0008004_abnormal_stomach_pH0.66195122
134MP0000749_muscle_degeneration0.66069174
135MP0003566_abnormal_cell_adhesion0.65645782
136MP0001764_abnormal_homeostasis0.65116866
137MP0001286_abnormal_eye_development0.64693142
138MP0010329_abnormal_lipoprotein_level0.64422109
139MP0002160_abnormal_reproductive_system0.61844466
140MP0009703_decreased_birth_body0.60879977
141MP0002161_abnormal_fertility/fecundity0.60586742

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)4.67414528
2Birth length less than 3rd percentile (HP:0003561)4.47279507
3Septo-optic dysplasia (HP:0100842)4.03073692
4Hyperglycinuria (HP:0003108)4.00305369
5Hyperglycinemia (HP:0002154)3.73413837
6Absent radius (HP:0003974)3.43593162
7Maternal diabetes (HP:0009800)3.38918507
8Ependymoma (HP:0002888)3.38261267
9Patellar aplasia (HP:0006443)3.36872766
10Carpal bone hypoplasia (HP:0001498)3.36811707
11Abnormality of glycine metabolism (HP:0010895)3.30203750
12Abnormality of serine family amino acid metabolism (HP:0010894)3.30203750
13Supernumerary spleens (HP:0009799)3.28022999
14Abnormality of pyrimidine metabolism (HP:0004353)3.24600369
15Multiple enchondromatosis (HP:0005701)3.20981960
16Oral leukoplakia (HP:0002745)3.20751183
17Aplasia involving forearm bones (HP:0009822)3.20220018
18Absent forearm bone (HP:0003953)3.20220018
19Aplasia/Hypoplasia of the patella (HP:0006498)3.13185868
20Impulsivity (HP:0100710)3.11999368
21Abnormality of the labia minora (HP:0012880)3.10531492
22Shawl scrotum (HP:0000049)3.10303846
23Premature ovarian failure (HP:0008209)3.09727486
24Sudden death (HP:0001699)3.03676421
25Abnormal lung lobation (HP:0002101)3.03240075
26Nephroblastoma (Wilms tumor) (HP:0002667)2.98127444
27Abnormality of monocarboxylic acid metabolism (HP:0010996)2.88719988
28Rhabdomyosarcoma (HP:0002859)2.83056358
29Right ventricular cardiomyopathy (HP:0011663)2.83014656
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.82617808
31Embryonal renal neoplasm (HP:0011794)2.80266819
32Hyperammonemia (HP:0001987)2.78888186
33Aplasia/hypoplasia of the humerus (HP:0006507)2.74648089
34Rib fusion (HP:0000902)2.74466919
35Bundle branch block (HP:0011710)2.74463364
36Selective tooth agenesis (HP:0001592)2.73920694
37Ventricular tachycardia (HP:0004756)2.73383138
38Choanal stenosis (HP:0000452)2.72700990
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64398494
40Chromsome breakage (HP:0040012)2.61283902
41Absent septum pellucidum (HP:0001331)2.61041174
42Abnormality of serum amino acid levels (HP:0003112)2.60165569
43Intrahepatic cholestasis (HP:0001406)2.55527649
44Hepatoblastoma (HP:0002884)2.55477904
45Partial duplication of thumb phalanx (HP:0009944)2.52810490
46Rough bone trabeculation (HP:0100670)2.50606174
47Secondary amenorrhea (HP:0000869)2.49440304
48Medulloblastoma (HP:0002885)2.48490594
49Abnormality of abdominal situs (HP:0011620)2.46911932
50Abdominal situs inversus (HP:0003363)2.46911932
51Bilateral microphthalmos (HP:0007633)2.46051643
52Short humerus (HP:0005792)2.45478112
53Aplasia/Hypoplasia involving the musculature (HP:0001460)2.45348865
54Abnormality of the septum pellucidum (HP:0007375)2.45053506
55Cortical dysplasia (HP:0002539)2.44661364
56Malnutrition (HP:0004395)2.39857550
57Hypobetalipoproteinemia (HP:0003563)2.38696343
58Facial hemangioma (HP:0000329)2.38695301
59Cerebral hypomyelination (HP:0006808)2.38360409
60Homocystinuria (HP:0002156)2.38042476
61Abnormality of homocysteine metabolism (HP:0010919)2.38042476
62Colon cancer (HP:0003003)2.35711138
63Gout (HP:0001997)2.34459739
64Breast aplasia (HP:0100783)2.33995523
65Absent thumb (HP:0009777)2.31290234
66Progressive external ophthalmoplegia (HP:0000590)2.28342155
67Neoplasm of striated muscle (HP:0009728)2.27891441
68Lipoatrophy (HP:0100578)2.25632960
69Palpitations (HP:0001962)2.24139121
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.22775257
71Hypoplastic left heart (HP:0004383)2.22049502
72Acute encephalopathy (HP:0006846)2.18564887
73Acute necrotizing encephalopathy (HP:0006965)2.17095779
74Increased serum pyruvate (HP:0003542)2.17094529
75Abnormality of glycolysis (HP:0004366)2.17094529
76Meckel diverticulum (HP:0002245)2.17028151
77Aplasia/Hypoplasia of the breasts (HP:0010311)2.16690663
78Abnormality of the ileum (HP:0001549)2.15281902
79Neoplasm of the oral cavity (HP:0100649)2.14742991
80Atrial fibrillation (HP:0005110)2.14148256
81Rectal fistula (HP:0100590)2.13965277
82Rectovaginal fistula (HP:0000143)2.13965277
83Partial duplication of the phalanx of hand (HP:0009999)2.13098245
84Lethargy (HP:0001254)2.11556500
85Patent foramen ovale (HP:0001655)2.09863886
86Degeneration of anterior horn cells (HP:0002398)2.09783538
87Abnormality of the anterior horn cell (HP:0006802)2.09783538
88Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09717164
89Dilated cardiomyopathy (HP:0001644)2.08401814
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07743770
91Nausea (HP:0002018)2.06338568
92Trismus (HP:0000211)2.05684372
93Astrocytoma (HP:0009592)2.04469808
94Abnormality of the astrocytes (HP:0100707)2.04469808
95Abnormality of methionine metabolism (HP:0010901)2.04290206
96Facial cleft (HP:0002006)2.03549824
97Hypoglycemic seizures (HP:0002173)2.00712376
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00172003
99Male infertility (HP:0003251)1.99868442
100Aplasia/Hypoplasia of the uvula (HP:0010293)1.99140149
101Vaginal fistula (HP:0004320)1.98363720
102Spastic diplegia (HP:0001264)1.97452274
103Abnormality of the preputium (HP:0100587)1.96812673
104Abnormality of lateral ventricle (HP:0030047)1.96129020
105Stenosis of the external auditory canal (HP:0000402)1.95563147
106Adrenal hypoplasia (HP:0000835)1.95168475
107Increased nuchal translucency (HP:0010880)1.94762671
108Neoplasm of the colon (HP:0100273)1.93909858
109Heart block (HP:0012722)1.93726990
110Rhabdomyolysis (HP:0003201)1.93455221
111Abnormality of chromosome stability (HP:0003220)1.93290548
112Short hallux (HP:0010109)1.91713724
113Ectopic kidney (HP:0000086)1.91130262
114Ureteral duplication (HP:0000073)1.91013291
115Megaloblastic anemia (HP:0001889)1.89848517
116Abnormal mitochondria in muscle tissue (HP:0008316)1.89609882
117Progressive muscle weakness (HP:0003323)1.89016606
118Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88526008
119Dicarboxylic aciduria (HP:0003215)1.88526008
120Abnormal number of erythroid precursors (HP:0012131)1.88444825
121Biliary tract neoplasm (HP:0100574)1.88279609
122Abnormality of nucleobase metabolism (HP:0010932)1.87872231
123Horseshoe kidney (HP:0000085)1.87437389
124Transposition of the great arteries (HP:0001669)1.87197431
125Abnormal connection of the cardiac segments (HP:0011545)1.87197431
126Abnormal ventriculo-arterial connection (HP:0011563)1.87197431
127Abnormal trabecular bone morphology (HP:0100671)1.86974131
128High anterior hairline (HP:0009890)1.86389476
129Primary atrial arrhythmia (HP:0001692)1.86223348
130Delayed CNS myelination (HP:0002188)1.85967557
131Duplication of thumb phalanx (HP:0009942)1.85448130
132Rimmed vacuoles (HP:0003805)1.84455681
133Abnormality of the salivary glands (HP:0010286)1.83805545
134Supraventricular tachycardia (HP:0004755)1.82754302
135Intestinal fistula (HP:0100819)1.82062310
136Abnormality of cells of the erythroid lineage (HP:0012130)1.82000796
137Agnosia (HP:0010524)1.81915859
138Hypolipoproteinemia (HP:0010981)1.81874422
139Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81822382
140Aplasia/Hypoplasia of the hallux (HP:0008362)1.81157314
141Myelomeningocele (HP:0002475)1.80920300
142Neoplasm of the pancreas (HP:0002894)1.80184261
143Delayed puberty (HP:0000823)1.79784844
144Abnormal cartilage morphology (HP:0002763)1.79607413
145Abnormal hair whorl (HP:0010721)1.79227386
146Muscle fiber splitting (HP:0003555)1.78467104
147Triphalangeal thumb (HP:0001199)1.78122848
148Supraventricular arrhythmia (HP:0005115)1.77622286
149Bifid tongue (HP:0010297)1.77580437
150Microretrognathia (HP:0000308)1.77215239
151Abnormal number of incisors (HP:0011064)1.76426672
152Gonadotropin excess (HP:0000837)1.75165295
153Reticulocytopenia (HP:0001896)1.74530343
154Optic nerve hypoplasia (HP:0000609)1.74026407
155Aplasia/Hypoplasia of the sternum (HP:0006714)1.73358383
156Glioma (HP:0009733)1.72420558
157Oligodactyly (HP:0012165)1.72384511
158Metaphyseal cupping (HP:0003021)1.71822320
159Atrioventricular block (HP:0001678)1.71004395
160Preaxial foot polydactyly (HP:0001841)1.69427794
161Cellular immunodeficiency (HP:0005374)1.68258491
162Proximal tubulopathy (HP:0000114)1.65526061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.60532892
2WEE13.63885308
3VRK23.36642810
4TTK3.29648128
5CDC73.09573376
6STK38L2.95008432
7PLK42.91703265
8LATS22.86457687
9TNIK2.79907002
10NEK12.72105383
11NEK22.57000671
12CDK122.40313340
13BCKDK2.39270208
14TAF12.34480436
15EPHA22.33346657
16EIF2AK12.29478555
17LATS12.16635553
18PBK2.15464574
19PLK12.04725533
20DMPK2.00093173
21MYLK1.96652589
22CDK191.94546473
23CDK71.88326175
24MAPKAPK31.77330255
25CHEK21.69284040
26RPS6KB21.68071873
27ERBB41.68003202
28MST41.67560269
29AKT31.66370634
30BRAF1.56667867
31MAP3K61.52924906
32SMG11.51049362
33TRIM281.50802777
34BMX1.43559076
35NUAK11.43141494
36AURKB1.42289500
37ACVR1B1.40602209
38TTN1.40359711
39AURKA1.38804651
40TESK21.36910604
41SRPK11.34180426
42MAP3K81.33575490
43TSSK61.33377113
44TIE11.32229449
45DYRK31.30876998
46CDK41.29162597
47BRSK21.28073447
48EEF2K1.23820304
49PDK31.20750174
50PDK41.20750174
51STK101.12317584
52MELK1.10486595
53PLK31.10250642
54STK31.07648905
55CHEK11.04161036
56KSR21.03662627
57ATR1.03238656
58MAP3K110.97452819
59PAK40.94978613
60NME20.93399441
61NME10.92585334
62DYRK20.91781759
63MAP3K90.89155294
64TAOK10.85305067
65PDK20.82368691
66RPS6KA40.82086528
67CDK80.81832021
68BRSK10.81279421
69CAMK1G0.79911070
70STK40.79804294
71NLK0.79151834
72RAF10.79094656
73FGFR10.79035835
74CDK20.78866702
75MTOR0.77769110
76PNCK0.75862825
77OBSCN0.72754677
78PINK10.72567307
79PRKCI0.71324539
80ICK0.70886105
81PAK10.70480139
82ATM0.68969938
83FLT30.68916060
84ARAF0.66357756
85ABL20.65410259
86CSNK1G10.65234158
87PIM10.61881421
88TYRO30.61868648
89EIF2AK30.61779265
90VRK10.60153235
91KDR0.57763516
92STK380.54874185
93PKN20.54083944
94CDK60.53034168
95MAPK110.52748599
96AKT20.52137168
97ZAK0.51895665
98CSNK1E0.51829858
99MOS0.50825588
100CDK10.50580418
101PRKDC0.49790359
102TLK10.48054217
103EIF2AK20.46996541
104CSNK2A10.46603263
105CSNK2A20.45853057
106OXSR10.45279490
107CAMK1D0.43097609
108MAP3K50.42917296
109MKNK10.41892964
110MET0.41448241
111MUSK0.41404530
112TGFBR10.41161970
113BRD40.40760536
114MKNK20.40745389
115BMPR1B0.40498185
116PRKAA10.39730555
117PASK0.39528651
118ALK0.39369657
119FGR0.37270694
120STK240.36222562
121WNK30.34504895
122PLK20.32996620
123DAPK30.32589763
124TAOK20.32185603
125RPS6KA10.31226429
126STK160.30887142
127CDK90.30483910
128CAMK2D0.29896605
129PTK20.28362062
130CAMK10.28180816
131CSNK1G20.27074221
132MAP3K100.26674953
133EGFR0.25920421
134KSR10.25698560
135GSK3B0.25694449

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.17966226
2Mismatch repair_Homo sapiens_hsa034303.09105637
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01515259
4RNA polymerase_Homo sapiens_hsa030202.67560560
5RNA transport_Homo sapiens_hsa030132.59769617
6One carbon pool by folate_Homo sapiens_hsa006702.51842004
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37636880
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26542512
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22368224
10Vitamin B6 metabolism_Homo sapiens_hsa007502.20697440
11Cell cycle_Homo sapiens_hsa041102.20209744
12Base excision repair_Homo sapiens_hsa034102.18379405
13Cysteine and methionine metabolism_Homo sapiens_hsa002702.05653740
14Biosynthesis of amino acids_Homo sapiens_hsa012302.05153101
15Proteasome_Homo sapiens_hsa030502.04544071
16Spliceosome_Homo sapiens_hsa030402.02919054
17Homologous recombination_Homo sapiens_hsa034401.98265822
18Nucleotide excision repair_Homo sapiens_hsa034201.95856484
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83285643
20Parkinsons disease_Homo sapiens_hsa050121.82959843
21Pyrimidine metabolism_Homo sapiens_hsa002401.82181718
22Folate biosynthesis_Homo sapiens_hsa007901.79560092
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.75597557
24RNA degradation_Homo sapiens_hsa030181.61421120
25Carbon metabolism_Homo sapiens_hsa012001.61158771
26Cardiac muscle contraction_Homo sapiens_hsa042601.58928153
27Basal transcription factors_Homo sapiens_hsa030221.54397694
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53377428
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52847557
30Ribosome_Homo sapiens_hsa030101.47815636
31Selenocompound metabolism_Homo sapiens_hsa004501.47510395
32Oxidative phosphorylation_Homo sapiens_hsa001901.46845934
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45554150
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44716507
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42988658
36Fanconi anemia pathway_Homo sapiens_hsa034601.42036911
37Fatty acid elongation_Homo sapiens_hsa000621.41649134
38Arginine biosynthesis_Homo sapiens_hsa002201.41635354
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.38188613
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.35553638
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.31626539
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30789934
43Propanoate metabolism_Homo sapiens_hsa006401.30194200
44p53 signaling pathway_Homo sapiens_hsa041151.27674279
45mRNA surveillance pathway_Homo sapiens_hsa030151.24183139
46Steroid biosynthesis_Homo sapiens_hsa001001.21068686
47Fatty acid degradation_Homo sapiens_hsa000711.19046596
48Pyruvate metabolism_Homo sapiens_hsa006201.18165090
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14466316
50Arginine and proline metabolism_Homo sapiens_hsa003301.09638909
51Dilated cardiomyopathy_Homo sapiens_hsa054141.07314158
52Nitrogen metabolism_Homo sapiens_hsa009101.06738881
53Pentose phosphate pathway_Homo sapiens_hsa000301.06636873
54Sulfur relay system_Homo sapiens_hsa041221.04884391
55Tryptophan metabolism_Homo sapiens_hsa003801.04402413
56Glutathione metabolism_Homo sapiens_hsa004801.04134591
57Fructose and mannose metabolism_Homo sapiens_hsa000510.99738074
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98906306
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97730907
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93836412
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91337520
62Tight junction_Homo sapiens_hsa045300.90726532
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90533825
64Protein export_Homo sapiens_hsa030600.88630392
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88526948
66beta-Alanine metabolism_Homo sapiens_hsa004100.87730199
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86322832
68Purine metabolism_Homo sapiens_hsa002300.84799403
69Non-homologous end-joining_Homo sapiens_hsa034500.83726445
70Peroxisome_Homo sapiens_hsa041460.83328646
71Wnt signaling pathway_Homo sapiens_hsa043100.81212431
72Alzheimers disease_Homo sapiens_hsa050100.80168411
73Butanoate metabolism_Homo sapiens_hsa006500.79552343
74Fatty acid metabolism_Homo sapiens_hsa012120.77527420
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75850808
76Oocyte meiosis_Homo sapiens_hsa041140.75439731
77Lysine degradation_Homo sapiens_hsa003100.67134967
78Phenylalanine metabolism_Homo sapiens_hsa003600.67022245
79Hippo signaling pathway_Homo sapiens_hsa043900.65278670
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63396045
81TGF-beta signaling pathway_Homo sapiens_hsa043500.62375001
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62226126
83Tyrosine metabolism_Homo sapiens_hsa003500.61195607
84Chemical carcinogenesis_Homo sapiens_hsa052040.60863165
85Linoleic acid metabolism_Homo sapiens_hsa005910.60790051
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59910417
87Retinol metabolism_Homo sapiens_hsa008300.59382318
88PPAR signaling pathway_Homo sapiens_hsa033200.58431966
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58361751
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57261873
91Galactose metabolism_Homo sapiens_hsa000520.54460740
92Metabolic pathways_Homo sapiens_hsa011000.52819632
93Epstein-Barr virus infection_Homo sapiens_hsa051690.50517765
94Basal cell carcinoma_Homo sapiens_hsa052170.48600158
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47564615
96Complement and coagulation cascades_Homo sapiens_hsa046100.47200545
97Vitamin digestion and absorption_Homo sapiens_hsa049770.44407102
98Hedgehog signaling pathway_Homo sapiens_hsa043400.41426917
99Huntingtons disease_Homo sapiens_hsa050160.39917498
100Thyroid cancer_Homo sapiens_hsa052160.38254573
101Fat digestion and absorption_Homo sapiens_hsa049750.37818676
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.37515047
103MicroRNAs in cancer_Homo sapiens_hsa052060.36463801
104Histidine metabolism_Homo sapiens_hsa003400.36097887
105Bladder cancer_Homo sapiens_hsa052190.35129595
106mTOR signaling pathway_Homo sapiens_hsa041500.33870984
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.33824345
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.33633489
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32342967
110Notch signaling pathway_Homo sapiens_hsa043300.31830083
111Adherens junction_Homo sapiens_hsa045200.28122810
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27955982
113Circadian rhythm_Homo sapiens_hsa047100.27936345
114Glycerolipid metabolism_Homo sapiens_hsa005610.26721156
115Colorectal cancer_Homo sapiens_hsa052100.25072521
116Regulation of autophagy_Homo sapiens_hsa041400.24803091
117Arachidonic acid metabolism_Homo sapiens_hsa005900.23738611
118Gap junction_Homo sapiens_hsa045400.23461546
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20107897
120ECM-receptor interaction_Homo sapiens_hsa045120.17716773
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16237293
122Melanogenesis_Homo sapiens_hsa049160.12997637
123Prostate cancer_Homo sapiens_hsa052150.12285421
124Melanoma_Homo sapiens_hsa052180.11644573
125Pathways in cancer_Homo sapiens_hsa052000.11199757
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10972932

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