RBX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.07373145
2ATP synthesis coupled proton transport (GO:0015986)6.65074466
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.65074466
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.21020997
5chaperone-mediated protein transport (GO:0072321)5.65968499
6respiratory electron transport chain (GO:0022904)5.40999387
7electron transport chain (GO:0022900)5.27966936
8cullin deneddylation (GO:0010388)4.73743101
9proteasome assembly (GO:0043248)4.67774273
10protein complex biogenesis (GO:0070271)4.67359368
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.51624691
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.51624691
13NADH dehydrogenase complex assembly (GO:0010257)4.51624691
14protein deneddylation (GO:0000338)4.45045016
15* protein neddylation (GO:0045116)4.41809616
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.41323022
17termination of RNA polymerase III transcription (GO:0006386)4.23011609
18transcription elongation from RNA polymerase III promoter (GO:0006385)4.23011609
19mitochondrial respiratory chain complex assembly (GO:0033108)4.19299503
20GTP biosynthetic process (GO:0006183)4.17214651
21ribosomal small subunit biogenesis (GO:0042274)4.07850599
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.01742437
237-methylguanosine mRNA capping (GO:0006370)3.90447520
24RNA capping (GO:0036260)3.85600131
257-methylguanosine RNA capping (GO:0009452)3.85600131
26sequestering of actin monomers (GO:0042989)3.75838349
27viral transcription (GO:0019083)3.74935142
28regulation of cellular amino acid metabolic process (GO:0006521)3.73606446
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.71354359
30negative regulation of ligase activity (GO:0051352)3.71354359
31regulation of mitochondrial translation (GO:0070129)3.70166214
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.70033941
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.68495451
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67264383
35cotranslational protein targeting to membrane (GO:0006613)3.67260869
36protein targeting to mitochondrion (GO:0006626)3.64730255
37translational termination (GO:0006415)3.62758684
38establishment of protein localization to mitochondrion (GO:0072655)3.59677732
39CENP-A containing nucleosome assembly (GO:0034080)3.59337403
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.58634573
41ribosomal small subunit assembly (GO:0000028)3.57311361
42protein targeting to ER (GO:0045047)3.57071975
43chromatin remodeling at centromere (GO:0031055)3.56783811
44rRNA modification (GO:0000154)3.56576402
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.54246392
46guanosine-containing compound biosynthetic process (GO:1901070)3.54171737
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53531967
48hydrogen ion transmembrane transport (GO:1902600)3.47106072
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46422661
50UTP biosynthetic process (GO:0006228)3.46422276
51protein localization to endoplasmic reticulum (GO:0070972)3.44701491
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.44371778
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.44371778
54signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.41416052
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.41416052
56signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.41416052
57respiratory chain complex IV assembly (GO:0008535)3.39452937
58establishment of protein localization to endoplasmic reticulum (GO:0072599)3.39246469
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.38870639
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.37316644
61protein localization to mitochondrion (GO:0070585)3.34367093
62pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.33020087
63purine nucleoside triphosphate biosynthetic process (GO:0009145)3.30719431
64oxidative phosphorylation (GO:0006119)3.29096026
65signal transduction involved in cell cycle checkpoint (GO:0072395)3.28897820
66signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28724334
67signal transduction involved in DNA damage checkpoint (GO:0072422)3.28724334
68ribosomal large subunit biogenesis (GO:0042273)3.28388536
69establishment of integrated proviral latency (GO:0075713)3.27304805
70protein complex disassembly (GO:0043241)3.26712098
71mitochondrial transport (GO:0006839)3.25501844
72translation (GO:0006412)3.24424149
73nucleoside triphosphate biosynthetic process (GO:0009142)3.21564391
74intracellular protein transmembrane import (GO:0044743)3.19901261
75water-soluble vitamin biosynthetic process (GO:0042364)3.19330540
76cytochrome complex assembly (GO:0017004)3.18345970
77macromolecular complex disassembly (GO:0032984)3.17169088
78maturation of SSU-rRNA (GO:0030490)3.16705140
79ATP biosynthetic process (GO:0006754)3.16486636
80positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16166954
81DNA damage response, detection of DNA damage (GO:0042769)3.15971251
82protein targeting to membrane (GO:0006612)3.15029372
83antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.10409806
84platelet dense granule organization (GO:0060155)3.10208190
85establishment of viral latency (GO:0019043)3.10019654
86proton transport (GO:0015992)3.09419167
87cellular protein complex disassembly (GO:0043624)3.09259878
88peptidyl-histidine modification (GO:0018202)3.08646522
89positive regulation of ligase activity (GO:0051351)3.06499427
90translational elongation (GO:0006414)3.04720066
91purine nucleoside monophosphate biosynthetic process (GO:0009127)3.04613085
92purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.04613085
93deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.04398250
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03097086
95hydrogen transport (GO:0006818)3.00104723
96viral life cycle (GO:0019058)2.99877467
97regulation of cellular amine metabolic process (GO:0033238)2.98911219
98pseudouridine synthesis (GO:0001522)2.95393045
99pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.95105196
100histone exchange (GO:0043486)2.94187662
101ribonucleoside triphosphate biosynthetic process (GO:0009201)2.94042647
102ATP hydrolysis coupled proton transport (GO:0015991)2.93457278
103energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.93457278
104nuclear-transcribed mRNA catabolic process (GO:0000956)2.92108782
105protein-cofactor linkage (GO:0018065)2.90418766
106deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.89602602
107transcription elongation from RNA polymerase I promoter (GO:0006362)2.88720346
108inner mitochondrial membrane organization (GO:0007007)2.88643338
109cellular component biogenesis (GO:0044085)2.87349479
110histone mRNA metabolic process (GO:0008334)2.86708400
111DNA deamination (GO:0045006)2.85441280
112CTP biosynthetic process (GO:0006241)2.84757256
113CTP metabolic process (GO:0046036)2.84757256
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84670840
115spliceosomal complex assembly (GO:0000245)2.83057438
116dopamine transport (GO:0015872)2.81418802
117translational initiation (GO:0006413)2.81228389
118central nervous system myelination (GO:0022010)2.80381911
119axon ensheathment in central nervous system (GO:0032291)2.80381911
120UTP metabolic process (GO:0046051)2.78807762
121tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78722734
122RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78722734
123spliceosomal snRNP assembly (GO:0000387)2.78138719
124regulation of ubiquitin-protein transferase activity (GO:0051438)2.77622050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.77771371
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.31465376
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.27071952
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.92144043
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53192362
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.24621149
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.23325789
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19731440
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.18999350
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.17509741
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12595571
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.08484653
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.99376346
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.68159692
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.41842078
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30105324
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24562294
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.10132536
19* VDR_23849224_ChIP-Seq_CD4+_Human2.09023156
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07913042
21ELK1_19687146_ChIP-ChIP_HELA_Human2.05023772
22DCP1A_22483619_ChIP-Seq_HELA_Human2.03237237
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91889355
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.90327797
25TAF15_26573619_Chip-Seq_HEK293_Human1.89370160
26VDR_22108803_ChIP-Seq_LS180_Human1.86771036
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84495170
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81780066
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80778378
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73475505
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72775722
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72191065
33TTF2_22483619_ChIP-Seq_HELA_Human1.71683950
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71229845
35ZNF274_21170338_ChIP-Seq_K562_Hela1.69772461
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69263259
37XRN2_22483619_ChIP-Seq_HELA_Human1.65731642
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59586297
39FOXP3_21729870_ChIP-Seq_TREG_Human1.56605563
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.53968477
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53077169
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50720311
43FUS_26573619_Chip-Seq_HEK293_Human1.49099401
44GABP_19822575_ChIP-Seq_HepG2_Human1.48634628
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48558415
46EZH2_22144423_ChIP-Seq_EOC_Human1.48315404
47GBX2_23144817_ChIP-Seq_PC3_Human1.47799677
48* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42345736
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35932398
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33263260
51* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32298752
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29089948
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28565406
54MYC_18940864_ChIP-ChIP_HL60_Human1.26375913
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23690678
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.23252565
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22987107
58HTT_18923047_ChIP-ChIP_STHdh_Human1.22879640
59IGF1R_20145208_ChIP-Seq_DFB_Human1.21997832
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21831756
61IRF1_19129219_ChIP-ChIP_H3396_Human1.21490856
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21039500
63EWS_26573619_Chip-Seq_HEK293_Human1.20014660
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16728249
65TP53_22573176_ChIP-Seq_HFKS_Human1.16464692
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13907232
67CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13806596
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13193538
69RNF2_27304074_Chip-Seq_NSC_Mouse1.12088973
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11675228
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.11672344
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10220036
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09994011
74* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09745551
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09634897
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.07217011
77SOX2_19829295_ChIP-Seq_ESCs_Human1.06522451
78NANOG_19829295_ChIP-Seq_ESCs_Human1.06522451
79ER_23166858_ChIP-Seq_MCF-7_Human1.05428466
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03150894
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02756176
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02546492
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01931555
84P300_19829295_ChIP-Seq_ESCs_Human1.00774060
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99058261
86FLI1_27457419_Chip-Seq_LIVER_Mouse0.97797435
87* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97005432
88* FOXA1_25329375_ChIP-Seq_VCAP_Human0.95197824
89* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95197824
90JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94041132
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.93819806
92* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93764224
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.93622199
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92306072
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91862867
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91038163
97* AR_20517297_ChIP-Seq_VCAP_Human0.88958180
98EED_16625203_ChIP-ChIP_MESCs_Mouse0.88002540
99ERG_20517297_ChIP-Seq_VCAP_Human0.87577385
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.86818651
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86355212
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85833424
103SALL4_22934838_ChIP-ChIP_CD34+_Human0.85305437
104SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.85231760
105SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84846149
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84413430
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.83741619
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82689800
109JUN_21703547_ChIP-Seq_K562_Human0.82453046
110* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82395541
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81969081
112REST_19997604_ChIP-ChIP_NEURONS_Mouse0.80677397
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80226482
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79948458
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79810502
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78453458
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77893412
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77832833
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77830766
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77526973
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77435185
122MYCN_18555785_ChIP-Seq_MESCs_Mouse0.77413606
123E2F7_22180533_ChIP-Seq_HELA_Human0.75634573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.88697520
2MP0001529_abnormal_vocalization3.61274723
3MP0009379_abnormal_foot_pigmentation3.16808836
4MP0003806_abnormal_nucleotide_metabolis3.00608631
5MP0001905_abnormal_dopamine_level2.92898238
6MP0006276_abnormal_autonomic_nervous2.65591037
7MP0001986_abnormal_taste_sensitivity2.42976444
8MP0002736_abnormal_nociception_after2.41807120
9MP0003011_delayed_dark_adaptation2.39983399
10MP0001968_abnormal_touch/_nociception2.31975870
11MP0005084_abnormal_gallbladder_morpholo2.24626479
12MP0003136_yellow_coat_color2.18038321
13MP0003122_maternal_imprinting2.14790774
14MP0001188_hyperpigmentation2.06983430
15MP0002735_abnormal_chemical_nociception2.03016051
16MP0002734_abnormal_mechanical_nocicepti2.02822419
17MP0006292_abnormal_olfactory_placode1.91229357
18MP0005423_abnormal_somatic_nervous1.87251322
19MP0004142_abnormal_muscle_tone1.85110619
20MP0009046_muscle_twitch1.84957763
21MP0002272_abnormal_nervous_system1.83744393
22MP0002163_abnormal_gland_morphology1.83374060
23MP0002102_abnormal_ear_morphology1.80720994
24MP0002638_abnormal_pupillary_reflex1.75545620
25MP0002064_seizures1.72798418
26MP0009745_abnormal_behavioral_response1.71070789
27MP0010094_abnormal_chromosome_stability1.69934062
28MP0008877_abnormal_DNA_methylation1.69634260
29MP0005171_absent_coat_pigmentation1.69215023
30MP0004270_analgesia1.62825937
31MP0000372_irregular_coat_pigmentation1.60139659
32MP0008995_early_reproductive_senescence1.59305810
33MP0001970_abnormal_pain_threshold1.58333031
34MP0008932_abnormal_embryonic_tissue1.56938716
35MP0003718_maternal_effect1.55260067
36MP0008789_abnormal_olfactory_epithelium1.48222138
37MP0002572_abnormal_emotion/affect_behav1.46955042
38MP0000778_abnormal_nervous_system1.46265778
39MP0003635_abnormal_synaptic_transmissio1.45554157
40MP0001440_abnormal_grooming_behavior1.44381314
41MP0002733_abnormal_thermal_nociception1.43457555
42MP0004957_abnormal_blastocyst_morpholog1.42280479
43MP0008872_abnormal_physiological_respon1.42274492
44MP0003123_paternal_imprinting1.41011825
45MP0001293_anophthalmia1.40446972
46MP0002751_abnormal_autonomic_nervous1.37905598
47MP0002938_white_spotting1.36179897
48MP0003121_genomic_imprinting1.36159447
49MP0001485_abnormal_pinna_reflex1.35260312
50MP0005409_darkened_coat_color1.32631174
51MP0002067_abnormal_sensory_capabilities1.32423908
52MP0002184_abnormal_innervation1.31434851
53MP0006072_abnormal_retinal_apoptosis1.31219550
54MP0010386_abnormal_urinary_bladder1.31118468
55MP0001486_abnormal_startle_reflex1.29162048
56MP0003693_abnormal_embryo_hatching1.29113399
57MP0003195_calcinosis1.28640808
58MP0005379_endocrine/exocrine_gland_phen1.28444538
59MP0010030_abnormal_orbit_morphology1.27725653
60MP0004742_abnormal_vestibular_system1.26050321
61MP0003315_abnormal_perineum_morphology1.25017663
62MP0001984_abnormal_olfaction1.23020634
63MP0002063_abnormal_learning/memory/cond1.22178198
64MP0006036_abnormal_mitochondrial_physio1.21766033
65MP0006035_abnormal_mitochondrial_morpho1.20683313
66MP0004215_abnormal_myocardial_fiber1.19821318
67MP0005645_abnormal_hypothalamus_physiol1.18441335
68MP0003787_abnormal_imprinting1.16349550
69MP0008875_abnormal_xenobiotic_pharmacok1.16169533
70MP0002277_abnormal_respiratory_mucosa1.14551530
71MP0003938_abnormal_ear_development1.13221786
72MP0000566_synostosis1.12467340
73MP0005499_abnormal_olfactory_system1.12314471
74MP0005394_taste/olfaction_phenotype1.12314471
75MP0000026_abnormal_inner_ear1.11672724
76MP0008260_abnormal_autophagy1.11657223
77MP0000631_abnormal_neuroendocrine_gland1.11479049
78MP0008058_abnormal_DNA_repair1.11421753
79MP0001963_abnormal_hearing_physiology1.10717787
80MP0005386_behavior/neurological_phenoty1.09699162
81MP0004924_abnormal_behavior1.09699162
82MP0003111_abnormal_nucleus_morphology1.07540324
83MP0002752_abnormal_somatic_nervous1.06228119
84MP0005646_abnormal_pituitary_gland1.04577892
85MP0005551_abnormal_eye_electrophysiolog1.04474509
86MP0002653_abnormal_ependyma_morphology1.03020973
87MP0002876_abnormal_thyroid_physiology1.01769163
88MP0003786_premature_aging1.00607049
89MP0002210_abnormal_sex_determination1.00257006
90MP0008057_abnormal_DNA_replication1.00015941
91* MP0003077_abnormal_cell_cycle0.99993308
92MP0001764_abnormal_homeostasis0.99929973
93MP0002095_abnormal_skin_pigmentation0.99800814
94MP0005410_abnormal_fertilization0.99746022
95MP0000920_abnormal_myelination0.98453503
96MP0001727_abnormal_embryo_implantation0.98427620
97MP0003941_abnormal_skin_development0.97537698
98MP0000049_abnormal_middle_ear0.97310208
99MP0003567_abnormal_fetal_cardiomyocyte0.97243887
100MP0002234_abnormal_pharynx_morphology0.96058110
101MP0005389_reproductive_system_phenotype0.95449899
102MP0002882_abnormal_neuron_morphology0.94725202
103MP0002090_abnormal_vision0.94269865
104MP0001501_abnormal_sleep_pattern0.90857737
105MP0005253_abnormal_eye_physiology0.90407217
106MP0001919_abnormal_reproductive_system0.89246209
107MP0004859_abnormal_synaptic_plasticity0.89042477
108MP0002557_abnormal_social/conspecific_i0.87008296
109MP0003137_abnormal_impulse_conducting0.84556709
110MP0005075_abnormal_melanosome_morpholog0.84046299
111MP0002066_abnormal_motor_capabilities/c0.83119007
112MP0005408_hypopigmentation0.82395562
113MP0008007_abnormal_cellular_replicative0.81889301
114MP0004147_increased_porphyrin_level0.80831560
115MP0005174_abnormal_tail_pigmentation0.80438878
116MP0000653_abnormal_sex_gland0.80032696
117MP0000516_abnormal_urinary_system0.79329903
118MP0005367_renal/urinary_system_phenotyp0.79329903
119MP0001542_abnormal_bone_strength0.78706130
120MP0005332_abnormal_amino_acid0.78661324
121MP0000358_abnormal_cell_content/0.78418895
122MP0004145_abnormal_muscle_electrophysio0.78361623
123MP0005195_abnormal_posterior_eye0.78355299
124MP0001929_abnormal_gametogenesis0.78333835
125MP0003186_abnormal_redox_activity0.77570118
126MP0004133_heterotaxia0.76842372
127MP0002160_abnormal_reproductive_system0.76473221
128MP0001145_abnormal_male_reproductive0.75516485
129MP0002229_neurodegeneration0.75169406
130MP0005636_abnormal_mineral_homeostasis0.72611629
131MP0009697_abnormal_copulation0.72295610
132MP0002282_abnormal_trachea_morphology0.71878072
133MP0000955_abnormal_spinal_cord0.71799698
134MP0002837_dystrophic_cardiac_calcinosis0.71377511
135MP0003698_abnormal_male_reproductive0.70653897
136MP0000681_abnormal_thyroid_gland0.70630282
137MP0009250_abnormal_appendicular_skeleto0.69504697
138MP0003950_abnormal_plasma_membrane0.67483276
139MP0002822_catalepsy0.66126073

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.45227670
2Abnormal mitochondria in muscle tissue (HP:0008316)5.76463882
3Mitochondrial inheritance (HP:0001427)5.64841033
4Progressive macrocephaly (HP:0004481)5.36858973
5Acute encephalopathy (HP:0006846)4.89974780
6Increased CSF lactate (HP:0002490)4.75792557
7Hepatocellular necrosis (HP:0001404)4.71592056
8Increased hepatocellular lipid droplets (HP:0006565)4.39270634
9Increased serum pyruvate (HP:0003542)4.25385303
10Abnormality of glycolysis (HP:0004366)4.25385303
11Renal Fanconi syndrome (HP:0001994)3.89612057
12Hepatic necrosis (HP:0002605)3.79864347
13Lipid accumulation in hepatocytes (HP:0006561)3.73133767
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.72104973
153-Methylglutaconic aciduria (HP:0003535)3.58778133
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.55811779
17Congenital, generalized hypertrichosis (HP:0004540)3.52058264
18Optic disc pallor (HP:0000543)3.44199951
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.41968826
20Exercise intolerance (HP:0003546)3.31069569
21Leukodystrophy (HP:0002415)3.28058080
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.27524326
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.27524326
24Respiratory failure (HP:0002878)3.21557805
25Increased serum lactate (HP:0002151)3.05834649
26Abnormality of cells of the erythroid lineage (HP:0012130)3.01124701
27Hypothermia (HP:0002045)2.98979896
28Exertional dyspnea (HP:0002875)2.98074543
29Cerebral hypomyelination (HP:0006808)2.94506870
30Methylmalonic acidemia (HP:0002912)2.92048521
31Cerebral edema (HP:0002181)2.89826394
32Lactic acidosis (HP:0003128)2.88467581
33Increased intramyocellular lipid droplets (HP:0012240)2.86966347
34Parakeratosis (HP:0001036)2.86717650
35Medial flaring of the eyebrow (HP:0010747)2.77839663
36Neuroendocrine neoplasm (HP:0100634)2.72972311
37Abnormal number of erythroid precursors (HP:0012131)2.72409348
38Generalized aminoaciduria (HP:0002909)2.62113151
39Pheochromocytoma (HP:0002666)2.60024957
40Abnormal hair whorl (HP:0010721)2.59003866
41Gait imbalance (HP:0002141)2.57665537
42Abnormality of midbrain morphology (HP:0002418)2.53546098
43Molar tooth sign on MRI (HP:0002419)2.53546098
44Congenital primary aphakia (HP:0007707)2.51259771
45Methylmalonic aciduria (HP:0012120)2.46296687
46Respiratory difficulties (HP:0002880)2.45065666
47Abnormality of renal resorption (HP:0011038)2.40510414
48Nephrogenic diabetes insipidus (HP:0009806)2.40235694
49Lethargy (HP:0001254)2.39120226
50Macrocytic anemia (HP:0001972)2.30251235
51Oral leukoplakia (HP:0002745)2.28286007
52Abnormality of methionine metabolism (HP:0010901)2.26029622
53Colon cancer (HP:0003003)2.25970901
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24371948
55Reticulocytopenia (HP:0001896)2.24193614
56Vaginal atresia (HP:0000148)2.21621556
57Limb dystonia (HP:0002451)2.19459117
58Genital tract atresia (HP:0001827)2.18417234
59Congenital ichthyosiform erythroderma (HP:0007431)2.17965439
60Septo-optic dysplasia (HP:0100842)2.15865603
61X-linked dominant inheritance (HP:0001423)2.15115705
62Emotional lability (HP:0000712)2.14345426
63Increased muscle lipid content (HP:0009058)2.14206792
64CNS demyelination (HP:0007305)2.05038504
65Focal motor seizures (HP:0011153)2.04872642
66Abnormal pupillary function (HP:0007686)2.04792799
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04676469
68Atonic seizures (HP:0010819)1.98717727
69Hyperglycinemia (HP:0002154)1.98351204
70Pancreatic fibrosis (HP:0100732)1.97592731
71Myokymia (HP:0002411)1.96883866
72Delusions (HP:0000746)1.96153377
73Nephronophthisis (HP:0000090)1.95424964
74Aplasia/hypoplasia of the uterus (HP:0008684)1.95274110
75Amniotic constriction ring (HP:0009775)1.93718411
76Abnormality of placental membranes (HP:0011409)1.93718411
77Microvesicular hepatic steatosis (HP:0001414)1.92667991
78Abnormality of serum amino acid levels (HP:0003112)1.91931321
79True hermaphroditism (HP:0010459)1.91798642
80Poor suck (HP:0002033)1.89828347
81Pancreatic cysts (HP:0001737)1.87348924
82Pallor (HP:0000980)1.86232109
83Megaloblastic anemia (HP:0001889)1.86202814
84Breast hypoplasia (HP:0003187)1.84316831
85Adrenal hypoplasia (HP:0000835)1.82909293
86Type I transferrin isoform profile (HP:0003642)1.81118895
87Birth length less than 3rd percentile (HP:0003561)1.80925692
88Sclerocornea (HP:0000647)1.77496031
89CNS hypomyelination (HP:0003429)1.75833910
90Nausea (HP:0002018)1.73835369
91Abnormality of the anterior horn cell (HP:0006802)1.73203608
92Degeneration of anterior horn cells (HP:0002398)1.73203608
93Renal cortical cysts (HP:0000803)1.72579142
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71726606
95Abnormal protein N-linked glycosylation (HP:0012347)1.71726606
96Abnormal protein glycosylation (HP:0012346)1.71726606
97Abnormal glycosylation (HP:0012345)1.71726606
98Abnormality of vitamin B metabolism (HP:0004340)1.71560359
99Abnormality of the labia minora (HP:0012880)1.71211697
100Hyperphosphaturia (HP:0003109)1.71137409
101Absent thumb (HP:0009777)1.70287982
102Congenital stationary night blindness (HP:0007642)1.69920723
103Pancytopenia (HP:0001876)1.69436223
104Abnormal respiratory motile cilium morphology (HP:0005938)1.68918737
105Abnormal respiratory epithelium morphology (HP:0012253)1.68918737
106Absent septum pellucidum (HP:0001331)1.68593917
107Male pseudohermaphroditism (HP:0000037)1.68221218
108Esotropia (HP:0000565)1.67068078
109Abnormal ciliary motility (HP:0012262)1.65915000
110Meckel diverticulum (HP:0002245)1.65535068
111Irregular epiphyses (HP:0010582)1.64934786
112Retinal dysplasia (HP:0007973)1.64931573
113Poor coordination (HP:0002370)1.63605169
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63534212
115Postnatal microcephaly (HP:0005484)1.63389029
116Abnormality of the vitamin B12 metabolism (HP:0004341)1.63223131
117Sensory axonal neuropathy (HP:0003390)1.62913579
118Aplastic anemia (HP:0001915)1.62229315
119Reduced antithrombin III activity (HP:0001976)1.60966555
120Unsteady gait (HP:0002317)1.58766664
121Dicarboxylic aciduria (HP:0003215)1.58729016
122Abnormality of dicarboxylic acid metabolism (HP:0010995)1.58729016
123Abnormality of the ileum (HP:0001549)1.58200500
124Triphalangeal thumb (HP:0001199)1.56701338
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.56304399
126Aplasia/Hypoplasia of the lens (HP:0008063)1.55780963
127Blindness (HP:0000618)1.54845519
128Abnormality of the septum pellucidum (HP:0007375)1.54131334
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.54048872
130Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.54048872
131Progressive external ophthalmoplegia (HP:0000590)1.51461705
132Renal tubular dysfunction (HP:0000124)1.49314588
133Glycosuria (HP:0003076)1.49297248
134Abnormality of urine glucose concentration (HP:0011016)1.49297248
135Stenosis of the external auditory canal (HP:0000402)1.48567401
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.48278651
137Abnormality of alanine metabolism (HP:0010916)1.48278651
138Hyperalaninemia (HP:0003348)1.48278651
139Hypoplasia of the uterus (HP:0000013)1.46923254
140Patellar aplasia (HP:0006443)1.46751189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.13388245
2BUB13.23930871
3STK163.19693781
4CASK3.16076276
5MAP3K122.66110048
6NME12.49015633
7PBK2.31008140
8NME22.29906218
9EIF2AK12.19936568
10CDC72.10655145
11SRPK12.09373503
12BCR2.06373677
13VRK12.03927553
14STK391.97484943
15NUAK11.96281643
16MST41.93991282
17ARAF1.93700988
18MAP4K21.87275818
19TNIK1.85070983
20LIMK11.82399618
21BMPR1B1.78194532
22OXSR11.75415858
23CDK191.75193525
24MAP2K71.74103371
25TLK11.64163467
26TAF11.60465346
27TRIM281.57073180
28WEE11.56243928
29NEK11.55579468
30PLK41.54205765
31DYRK21.52616288
32EIF2AK31.46178676
33CCNB11.44669040
34PLK21.39650184
35TSSK61.39405462
36MYLK1.33394964
37GRK11.33242795
38BCKDK1.32194808
39BRAF1.30005832
40MAPK131.29066887
41MARK11.26959063
42MKNK11.26946909
43PIM21.24256531
44MAPKAPK51.22468982
45GRK51.21783482
46BMPR21.20352065
47ADRBK21.17656280
48PNCK1.15939607
49CSNK1G31.09084260
50GRK71.08019023
51TESK21.07995277
52MUSK1.07437960
53INSRR1.06104721
54FRK1.01077358
55UHMK11.00199945
56PLK30.99067514
57CDK80.98009359
58MKNK20.93862052
59AURKA0.88865690
60CAMK2B0.87871820
61TTK0.84347933
62OBSCN0.83286770
63YES10.82974708
64AKT30.80004905
65MAP3K40.76971248
66MINK10.75216653
67AURKB0.74844228
68IRAK20.73957091
69ADRBK10.73936441
70ZAK0.73590171
71WNK40.71129566
72ABL20.70257984
73CDK140.68566674
74TEC0.67974296
75CAMK2A0.67319320
76EIF2AK20.66639628
77IRAK40.64705436
78CAMK2D0.63038674
79CHEK20.62671108
80PLK10.61694833
81CDK180.61270942
82ERBB30.61263990
83NEK60.60407800
84BRSK20.58460313
85CSNK1G10.57288650
86CSNK1G20.57272880
87PRKCE0.57150666
88PHKG10.57086642
89PHKG20.57086642
90ACVR1B0.55484979
91PAK30.54879465
92NTRK30.54658860
93CSNK2A10.54554723
94CDK150.54493946
95TESK10.54451274
96PRKCG0.54346385
97CAMK2G0.52870192
98CDK11A0.52815559
99RPS6KA50.52448192
100PRPF4B0.52411041
101TIE10.51005675
102ROCK20.50976487
103CDK30.49757218
104ATR0.49402245
105SIK30.49275189
106PASK0.48994634
107PKN10.48851066
108KDR0.48054231
109WNK30.47361334
110BRSK10.46848794
111CSNK1A1L0.46570572
112STK40.46447676
113TXK0.45676134
114DAPK10.45009974
115CSNK2A20.43701684
116FGR0.42080017
117TAOK30.41651213
118DAPK30.41247161
119CSNK1A10.40386575
120PAK10.40236226
121PDK20.39358664
122TGFBR10.39301996
123DYRK30.38811081
124PRKG10.37908924
125IRAK10.37300422
126PRKACA0.36193626
127STK30.35776975
128EPHB20.34834848
129STK240.34697779
130ILK0.33932461
131PINK10.33880706
132NTRK10.32938478

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.27546531
2Proteasome_Homo sapiens_hsa030504.45519612
3Parkinsons disease_Homo sapiens_hsa050124.43469386
4Ribosome_Homo sapiens_hsa030104.07000200
5RNA polymerase_Homo sapiens_hsa030203.40057730
6Huntingtons disease_Homo sapiens_hsa050163.31852528
7Alzheimers disease_Homo sapiens_hsa050103.25418533
8Protein export_Homo sapiens_hsa030603.18861424
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.52260306
10Collecting duct acid secretion_Homo sapiens_hsa049662.30456044
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00424734
12Cardiac muscle contraction_Homo sapiens_hsa042601.89977282
13Pyrimidine metabolism_Homo sapiens_hsa002401.81510226
14Spliceosome_Homo sapiens_hsa030401.81184968
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68385358
16Basal transcription factors_Homo sapiens_hsa030221.67264381
17DNA replication_Homo sapiens_hsa030301.66828423
18Vibrio cholerae infection_Homo sapiens_hsa051101.66335108
19Mismatch repair_Homo sapiens_hsa034301.63036924
20Homologous recombination_Homo sapiens_hsa034401.55016814
21Synaptic vesicle cycle_Homo sapiens_hsa047211.38941282
22* Nucleotide excision repair_Homo sapiens_hsa034201.33120381
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32699422
24One carbon pool by folate_Homo sapiens_hsa006701.31223126
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28178169
26Fatty acid elongation_Homo sapiens_hsa000621.19414511
27Purine metabolism_Homo sapiens_hsa002301.18623057
28Nicotine addiction_Homo sapiens_hsa050331.18334121
29Rheumatoid arthritis_Homo sapiens_hsa053231.16100430
30Phototransduction_Homo sapiens_hsa047441.09809763
31RNA transport_Homo sapiens_hsa030131.07313464
32Propanoate metabolism_Homo sapiens_hsa006401.07147807
33RNA degradation_Homo sapiens_hsa030181.06530776
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05624207
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98884148
36Serotonergic synapse_Homo sapiens_hsa047260.98352681
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95885380
38Ether lipid metabolism_Homo sapiens_hsa005650.93366509
39Steroid biosynthesis_Homo sapiens_hsa001000.93328522
40Base excision repair_Homo sapiens_hsa034100.91230901
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89518734
42Fanconi anemia pathway_Homo sapiens_hsa034600.88362569
43Nitrogen metabolism_Homo sapiens_hsa009100.83330960
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82630988
45Sulfur relay system_Homo sapiens_hsa041220.82615740
46Phagosome_Homo sapiens_hsa041450.80752094
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79623148
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78763541
49Non-homologous end-joining_Homo sapiens_hsa034500.77126501
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76657884
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73040888
52Butanoate metabolism_Homo sapiens_hsa006500.72162457
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70716584
54Chemical carcinogenesis_Homo sapiens_hsa052040.69207583
55Epstein-Barr virus infection_Homo sapiens_hsa051690.67386282
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67325466
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.67036689
58Peroxisome_Homo sapiens_hsa041460.65826219
59Regulation of autophagy_Homo sapiens_hsa041400.64907210
60GABAergic synapse_Homo sapiens_hsa047270.64038115
61Caffeine metabolism_Homo sapiens_hsa002320.63772014
62Arachidonic acid metabolism_Homo sapiens_hsa005900.63471157
63Metabolic pathways_Homo sapiens_hsa011000.63396822
64Sphingolipid metabolism_Homo sapiens_hsa006000.62624735
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62246045
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61802632
67* Cell cycle_Homo sapiens_hsa041100.60487892
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59753446
69Selenocompound metabolism_Homo sapiens_hsa004500.58029373
70Taste transduction_Homo sapiens_hsa047420.55060689
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54614166
72Tryptophan metabolism_Homo sapiens_hsa003800.53589108
73Graft-versus-host disease_Homo sapiens_hsa053320.52223602
74Morphine addiction_Homo sapiens_hsa050320.51504419
75Type I diabetes mellitus_Homo sapiens_hsa049400.50243094
76Autoimmune thyroid disease_Homo sapiens_hsa053200.50130242
77Alcoholism_Homo sapiens_hsa050340.49772630
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49762592
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.48873213
80Dopaminergic synapse_Homo sapiens_hsa047280.48481283
81Glutathione metabolism_Homo sapiens_hsa004800.47407835
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.45926083
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45876169
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45727773
85Sulfur metabolism_Homo sapiens_hsa009200.45019490
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44324378
87Retinol metabolism_Homo sapiens_hsa008300.43994957
88Long-term depression_Homo sapiens_hsa047300.43589744
89Asthma_Homo sapiens_hsa053100.42314148
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.42197595
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41389470
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40384400
93Linoleic acid metabolism_Homo sapiens_hsa005910.40083696
94Allograft rejection_Homo sapiens_hsa053300.39121341
95Glutamatergic synapse_Homo sapiens_hsa047240.37701625
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37560080
97beta-Alanine metabolism_Homo sapiens_hsa004100.37504447
98mRNA surveillance pathway_Homo sapiens_hsa030150.37437123
99* Oocyte meiosis_Homo sapiens_hsa041140.36115209
100Vitamin digestion and absorption_Homo sapiens_hsa049770.34990556
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34169685
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34090584
103Circadian entrainment_Homo sapiens_hsa047130.32726255
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.32121661
105Folate biosynthesis_Homo sapiens_hsa007900.30859752
106Amphetamine addiction_Homo sapiens_hsa050310.29857451
107Vitamin B6 metabolism_Homo sapiens_hsa007500.29754163
108Axon guidance_Homo sapiens_hsa043600.27170603
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25641648
110Mineral absorption_Homo sapiens_hsa049780.24925246
111Tyrosine metabolism_Homo sapiens_hsa003500.24327687
112Primary immunodeficiency_Homo sapiens_hsa053400.24258837
113Olfactory transduction_Homo sapiens_hsa047400.23876393
114Cholinergic synapse_Homo sapiens_hsa047250.23246096
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21254061
116Systemic lupus erythematosus_Homo sapiens_hsa053220.20282090
117Cocaine addiction_Homo sapiens_hsa050300.19994385
118Pyruvate metabolism_Homo sapiens_hsa006200.19316038
119N-Glycan biosynthesis_Homo sapiens_hsa005100.16703064
120* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16216381
121Calcium signaling pathway_Homo sapiens_hsa040200.13282456
122Hedgehog signaling pathway_Homo sapiens_hsa043400.12062834
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11668956
124Long-term potentiation_Homo sapiens_hsa047200.09581277
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09335256
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.08636474
127Phenylalanine metabolism_Homo sapiens_hsa003600.07850572
128Arginine and proline metabolism_Homo sapiens_hsa003300.07693183
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.07415629
130p53 signaling pathway_Homo sapiens_hsa041150.07171178
131Ras signaling pathway_Homo sapiens_hsa040140.06174536

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