RC3H2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.18471006
2nuclear pore organization (GO:0006999)4.45989011
3regulation of transforming growth factor beta2 production (GO:0032909)4.10627223
4presynaptic membrane assembly (GO:0097105)3.94994140
5regulation of NFAT protein import into nucleus (GO:0051532)3.80070961
6mitotic sister chromatid cohesion (GO:0007064)3.68724932
7neuron cell-cell adhesion (GO:0007158)3.61886030
8pore complex assembly (GO:0046931)3.57003007
9presynaptic membrane organization (GO:0097090)3.47933904
10negative regulation of DNA repair (GO:0045738)3.38842345
11protein localization to microtubule (GO:0035372)3.37949184
12NLS-bearing protein import into nucleus (GO:0006607)3.37878501
13axonal fasciculation (GO:0007413)3.37510779
14neuron recognition (GO:0008038)3.16696573
15dendritic spine morphogenesis (GO:0060997)3.14135571
16monoubiquitinated protein deubiquitination (GO:0035520)3.06520078
17histone H3-K4 trimethylation (GO:0080182)3.00110131
18regulation of protein polyubiquitination (GO:1902914)2.99090902
19interkinetic nuclear migration (GO:0022027)2.98875597
20embryonic retina morphogenesis in camera-type eye (GO:0060059)2.98809082
21ionotropic glutamate receptor signaling pathway (GO:0035235)2.93643104
22regulation of RNA export from nucleus (GO:0046831)2.93192096
23negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.92648272
24transmission of nerve impulse (GO:0019226)2.91714003
25vocalization behavior (GO:0071625)2.90006397
26gastrulation with mouth forming second (GO:0001702)2.86730679
27regulation of sarcomere organization (GO:0060297)2.82883186
28regulation of short-term neuronal synaptic plasticity (GO:0048172)2.80570718
29embryonic camera-type eye morphogenesis (GO:0048596)2.78994103
30hippo signaling (GO:0035329)2.78942329
31glutamate receptor signaling pathway (GO:0007215)2.78495060
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77740343
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74002966
34central nervous system projection neuron axonogenesis (GO:0021952)2.72883994
35negative regulation of neurotransmitter secretion (GO:0046929)2.72753041
36regulation of pigment cell differentiation (GO:0050932)2.72443162
37cerebral cortex radially oriented cell migration (GO:0021799)2.71559087
38histone H3-K36 demethylation (GO:0070544)2.70240182
39pre-miRNA processing (GO:0031054)2.69450440
40startle response (GO:0001964)2.68975263
41dendrite morphogenesis (GO:0048813)2.68285741
42peptidyl-threonine phosphorylation (GO:0018107)2.67588726
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.67550967
44peptidyl-threonine modification (GO:0018210)2.67357166
45morphogenesis of an epithelial sheet (GO:0002011)2.66914371
46lipid translocation (GO:0034204)2.66559052
47phospholipid translocation (GO:0045332)2.66559052
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.64592167
49protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.63841600
50protein localization to synapse (GO:0035418)2.60986140
51negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60263801
52glucocorticoid receptor signaling pathway (GO:0042921)2.58577863
53positive regulation of synapse assembly (GO:0051965)2.57081988
54stress granule assembly (GO:0034063)2.56208553
55gamma-aminobutyric acid signaling pathway (GO:0007214)2.55727411
56regulation of Rac protein signal transduction (GO:0035020)2.55460615
57G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54219320
58nerve growth factor signaling pathway (GO:0038180)2.53204494
59regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.53085742
60regulation of synapse assembly (GO:0051963)2.51783713
61negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.51692203
62negative regulation of translation, ncRNA-mediated (GO:0040033)2.51692203
63regulation of translation, ncRNA-mediated (GO:0045974)2.51692203
64limb bud formation (GO:0060174)2.51627769
65protein localization to microtubule cytoskeleton (GO:0072698)2.50788491
66myoblast fusion (GO:0007520)2.50505157
67regulation of establishment of cell polarity (GO:2000114)2.49933110
68regulation of nucleobase-containing compound transport (GO:0032239)2.48285156
69fibroblast migration (GO:0010761)2.48246949
70synaptic transmission, glutamatergic (GO:0035249)2.47396910
71retina layer formation (GO:0010842)2.47289753
72embryonic foregut morphogenesis (GO:0048617)2.47120785
73cerebellar Purkinje cell differentiation (GO:0021702)2.45517706
74central nervous system neuron axonogenesis (GO:0021955)2.44747023
75negative regulation of potassium ion transmembrane transport (GO:1901380)2.44247401
76neuron-neuron synaptic transmission (GO:0007270)2.44055861
77positive regulation of cardiac muscle hypertrophy (GO:0010613)2.43964770
78positive regulation of muscle hypertrophy (GO:0014742)2.43964770
79histone H3-K9 demethylation (GO:0033169)2.43742382
80regulation of dendritic spine morphogenesis (GO:0061001)2.43680576
81negative regulation of neurotransmitter transport (GO:0051589)2.43561209
82pericardium development (GO:0060039)2.43514867
83regulation of cAMP-dependent protein kinase activity (GO:2000479)2.43317841
84cyclic nucleotide catabolic process (GO:0009214)2.42894008
85insulin-like growth factor receptor signaling pathway (GO:0048009)2.41807418
86postsynaptic membrane organization (GO:0001941)2.41597348
87locomotory exploration behavior (GO:0035641)2.40117339
88neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.40035691
89regulation of glutamate receptor signaling pathway (GO:1900449)2.37882821
90cell adhesion mediated by integrin (GO:0033627)2.37827823
91membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.37580447
92neuronal ion channel clustering (GO:0045161)2.37576265
93positive regulation of insulin receptor signaling pathway (GO:0046628)2.36892530
94positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.36486204
95synapse assembly (GO:0007416)2.35834343
96dendritic spine organization (GO:0097061)2.35731277
97neuronal action potential propagation (GO:0019227)2.34087083
98SMAD protein complex assembly (GO:0007183)2.31871948
99regulation of postsynaptic membrane potential (GO:0060078)2.30673090
100regulation of excitatory postsynaptic membrane potential (GO:0060079)2.30238829
101dendrite development (GO:0016358)2.29940547
102plasma membrane repair (GO:0001778)2.29614006
103protein localization to cytoskeleton (GO:0044380)2.29117570
104anatomical structure arrangement (GO:0048532)2.28898543
105positive regulation of cardiac muscle cell differentiation (GO:2000727)2.27852215
106organelle transport along microtubule (GO:0072384)2.27836362
107microtubule anchoring (GO:0034453)2.27592403
108cAMP catabolic process (GO:0006198)2.27360169
109regulation of growth hormone secretion (GO:0060123)2.27125207
110dosage compensation (GO:0007549)2.27004392
111corticosteroid receptor signaling pathway (GO:0031958)2.26905820
112regulation of synaptic vesicle exocytosis (GO:2000300)2.26768128
113regulation of dendritic spine development (GO:0060998)2.25715199
114clathrin coat assembly (GO:0048268)2.25663977
115histone lysine demethylation (GO:0070076)2.24553485
116innervation (GO:0060384)2.24501239
117cytoplasmic mRNA processing body assembly (GO:0033962)2.23849568
118hemidesmosome assembly (GO:0031581)2.22579831
119establishment of nucleus localization (GO:0040023)2.22150717
120inner ear receptor cell development (GO:0060119)2.21771837
121regulation of muscle hypertrophy (GO:0014743)2.21486710
122protein K48-linked deubiquitination (GO:0071108)2.21179563
123spinal cord motor neuron differentiation (GO:0021522)2.20559361
124vesicle transport along microtubule (GO:0047496)2.20497435
125syncytium formation by plasma membrane fusion (GO:0000768)2.20324401
126regulation of cardiac muscle hypertrophy (GO:0010611)2.19748144
127regulation of neuron migration (GO:2001222)2.19083524
128negative regulation of vascular permeability (GO:0043116)2.19033549
129cytoskeletal anchoring at plasma membrane (GO:0007016)2.18568618
130layer formation in cerebral cortex (GO:0021819)2.18382546
131regulation of DNA endoreduplication (GO:0032875)2.17883473
132L-amino acid import (GO:0043092)2.16843273
133phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.16350667
134negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.15598009
135regulation of synaptic transmission, glutamatergic (GO:0051966)2.15279348
136negative regulation of keratinocyte proliferation (GO:0010839)2.15169220
137positive regulation of dendritic spine morphogenesis (GO:0061003)2.14686158
138positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.13861815
139regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.13861815
140heart morphogenesis (GO:0003007)2.12597456
141asymmetric protein localization (GO:0008105)2.12539843
142long-term synaptic potentiation (GO:0060291)2.12037689
143embryonic eye morphogenesis (GO:0048048)2.11857245
144regulation of synaptic transmission, GABAergic (GO:0032228)2.11333811
145peptidyl-serine phosphorylation (GO:0018105)2.10621138
146axon extension (GO:0048675)2.10532072
147suckling behavior (GO:0001967)2.10410290
148histone demethylation (GO:0016577)2.10354427
149positive regulation of cellular response to insulin stimulus (GO:1900078)2.10252348
150paraxial mesoderm development (GO:0048339)2.10036644
151regulation of axon guidance (GO:1902667)2.09824531
152ectodermal placode formation (GO:0060788)2.09728211
153negative regulation of histone methylation (GO:0031061)2.08631058
154myelin assembly (GO:0032288)2.08460820
155calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.07705495
156detection of calcium ion (GO:0005513)2.07353722
157chondrocyte development (GO:0002063)2.06873614
158regulation of centriole replication (GO:0046599)2.06647841
159regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.06369546
160regulation of axon extension involved in axon guidance (GO:0048841)2.05723292
161synapse organization (GO:0050808)2.05207374
162negative regulation of dendrite development (GO:2000171)2.05156591
163embryonic viscerocranium morphogenesis (GO:0048703)2.04517257
164neuron projection extension (GO:1990138)2.04495738
165synaptic vesicle exocytosis (GO:0016079)2.03831142
166cerebellar granule cell differentiation (GO:0021707)2.02913260
167long-chain fatty acid biosynthetic process (GO:0042759)2.02560522
168apical protein localization (GO:0045176)2.01262138
169nucleus localization (GO:0051647)2.01234341
170synaptic vesicle endocytosis (GO:0048488)2.01087733
171negative regulation of axon extension (GO:0030517)2.00731948
172peptidyl-lysine trimethylation (GO:0018023)2.00217904
173membrane assembly (GO:0071709)2.00208920
174cell migration in hindbrain (GO:0021535)2.00186287
175somite development (GO:0061053)2.00184799
176membrane depolarization (GO:0051899)1.99695165
177ganglion development (GO:0061548)1.99402605
178regulation of respiratory system process (GO:0044065)1.99287284
179homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)1.99195531
180sympathetic nervous system development (GO:0048485)1.98371194
181exploration behavior (GO:0035640)1.97948184
182photoreceptor cell differentiation (GO:0046530)1.97881212

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.78690662
2EZH2_22144423_ChIP-Seq_EOC_Human3.28871052
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.00139869
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.56064526
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.46950667
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35822489
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33523492
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21480051
9TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.16346905
10TAF15_26573619_Chip-Seq_HEK293_Human2.15217164
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14289178
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11804997
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08501014
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07613105
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04287323
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03505877
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01653815
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.00979360
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.98980546
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.98077510
21CTNNB1_20460455_ChIP-Seq_HCT116_Human1.96205709
22FUS_26573619_Chip-Seq_HEK293_Human1.92054365
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.91697257
24* P300_19829295_ChIP-Seq_ESCs_Human1.91489836
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.86926145
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.86921654
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.86235493
28GATA1_22025678_ChIP-Seq_K562_Human1.84152213
29SMAD4_21799915_ChIP-Seq_A2780_Human1.83740379
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82947553
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.80833814
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77830886
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77830886
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76809108
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75771922
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74440026
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71893857
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71573368
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71284276
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71248254
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.71171079
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.68391816
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.65564940
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65310436
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.64531380
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63856254
47AR_21572438_ChIP-Seq_LNCaP_Human1.61981024
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60049749
49TP53_16413492_ChIP-PET_HCT116_Human1.59497246
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57813465
51STAT3_23295773_ChIP-Seq_U87_Human1.57631578
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.57408341
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.57081494
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.57027712
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56309292
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56124541
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.55911852
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55810996
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.52584430
60IGF1R_20145208_ChIP-Seq_DFB_Human1.51585163
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51260160
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48825415
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47949219
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45689773
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45689773
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.45510371
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45506208
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45479616
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44058642
70DROSHA_22980978_ChIP-Seq_HELA_Human1.44036526
71EWS_26573619_Chip-Seq_HEK293_Human1.41457319
72ER_23166858_ChIP-Seq_MCF-7_Human1.41055888
73AHR_22903824_ChIP-Seq_MCF-7_Human1.40656617
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.40043812
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39355512
76TCF4_23295773_ChIP-Seq_U87_Human1.38958733
77TP53_18474530_ChIP-ChIP_U2OS_Human1.38777785
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37712198
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.36978989
80SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36090309
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.35719196
82BRD4_25478319_ChIP-Seq_HGPS_Human1.35672029
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34748563
84* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34559740
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33243557
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32638286
87VDR_22108803_ChIP-Seq_LS180_Human1.32580605
88P53_22387025_ChIP-Seq_ESCs_Mouse1.32386146
89RNF2_27304074_Chip-Seq_NSC_Mouse1.31649071
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.31002662
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30265934
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27991616
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27948286
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.27844547
95AR_25329375_ChIP-Seq_VCAP_Human1.27527820
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27460843
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27460843
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26053689
99RUNX2_22187159_ChIP-Seq_PCA_Human1.24875294
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24224902
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.23477345
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.22260214
103FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21038563
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.20824820
105REST_21632747_ChIP-Seq_MESCs_Mouse1.20097548
106SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19983351
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.19732340
108FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18859124
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18537868
110BCAT_22108803_ChIP-Seq_LS180_Human1.18297076
111P300_18555785_Chip-Seq_ESCs_Mouse1.17614363
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16987306
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16810987
114SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15032582
115YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15004386
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14633913
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14318841
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14307498
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13680079
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.11632015
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11041922
122ISL1_27105846_Chip-Seq_CPCs_Mouse1.10851899
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10654432
124NMYC_18555785_Chip-Seq_ESCs_Mouse1.10580333
125TCF4_18268006_ChIP-ChIP_LS174T_Human1.10555540
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09705231
127AR_21909140_ChIP-Seq_LNCAP_Human1.09526107
128ZNF274_21170338_ChIP-Seq_K562_Hela1.09273773
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08761049
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08047152
131SOX9_26525672_Chip-Seq_HEART_Mouse1.07835347
132CJUN_26792858_Chip-Seq_BT549_Human1.07192263
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06950376
134GF1B_26923725_Chip-Seq_HPCs_Mouse1.06920091
135SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05421548
136SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05421548
137NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03670510
138* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02693977
139TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01451536
140TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01341161
141FLI1_21867929_ChIP-Seq_TH2_Mouse1.00469497
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99434097
143E2F7_22180533_ChIP-Seq_HELA_Human0.96349183
144TP63_23658742_ChIP-Seq_EP156T_Human0.95703287
145* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94759381
146FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94487256
147KDM2B_26808549_Chip-Seq_REH_Human0.94370733
148PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94018318
149TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93533539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.69547115
2MP0000569_abnormal_digit_pigmentation3.51722766
3MP0010352_gastrointestinal_tract_polyps3.30211050
4MP0004859_abnormal_synaptic_plasticity2.77405565
5MP0005171_absent_coat_pigmentation2.68493913
6MP0003705_abnormal_hypodermis_morpholog2.66114924
7MP0003787_abnormal_imprinting2.63293145
8MP0002877_abnormal_melanocyte_morpholog2.59472049
9MP0001188_hyperpigmentation2.52780579
10MP0004270_analgesia2.36746802
11MP0010234_abnormal_vibrissa_follicle2.32472165
12MP0000778_abnormal_nervous_system2.26924925
13MP0003950_abnormal_plasma_membrane2.26414971
14MP0003635_abnormal_synaptic_transmissio2.13981950
15MP0009780_abnormal_chondrocyte_physiolo2.09158793
16MP0001486_abnormal_startle_reflex2.06022118
17MP0005409_darkened_coat_color2.04019965
18MP0002009_preneoplasia2.00107261
19MP0003091_abnormal_cell_migration1.97163779
20MP0009745_abnormal_behavioral_response1.88691514
21MP0000537_abnormal_urethra_morphology1.85306456
22MP0002063_abnormal_learning/memory/cond1.80796198
23MP0005187_abnormal_penis_morphology1.73964342
24MP0005646_abnormal_pituitary_gland1.71661190
25MP0005423_abnormal_somatic_nervous1.67917627
26MP0002734_abnormal_mechanical_nocicepti1.66725570
27MP0009046_muscle_twitch1.66262390
28MP0001299_abnormal_eye_distance/1.65911753
29MP0004742_abnormal_vestibular_system1.64275505
30MP0001879_abnormal_lymphatic_vessel1.63733608
31MP0002572_abnormal_emotion/affect_behav1.62108763
32MP0001968_abnormal_touch/_nociception1.59197719
33MP0005076_abnormal_cell_differentiation1.58781014
34MP0004272_abnormal_basement_membrane1.58601111
35MP0006276_abnormal_autonomic_nervous1.58590579
36MP0005645_abnormal_hypothalamus_physiol1.58550038
37MP0003566_abnormal_cell_adhesion1.57609992
38MP0003122_maternal_imprinting1.55562976
39MP0003121_genomic_imprinting1.55136207
40MP0002272_abnormal_nervous_system1.54369145
41MP0002064_seizures1.53457684
42MP0002184_abnormal_innervation1.53028856
43MP0001440_abnormal_grooming_behavior1.49364764
44MP0002735_abnormal_chemical_nociception1.46012949
45MP0003221_abnormal_cardiomyocyte_apopto1.42418502
46MP0000733_abnormal_muscle_development1.41305950
47MP0002067_abnormal_sensory_capabilities1.41164487
48MP0000428_abnormal_craniofacial_morphol1.38745336
49MP0000015_abnormal_ear_pigmentation1.38174436
50MP0001984_abnormal_olfaction1.37969907
51MP0004233_abnormal_muscle_weight1.36835979
52MP0005503_abnormal_tendon_morphology1.36579684
53MP0003136_yellow_coat_color1.36211547
54MP0002697_abnormal_eye_size1.34408771
55MP0000631_abnormal_neuroendocrine_gland1.33983250
56MP0002557_abnormal_social/conspecific_i1.33978360
57MP0003937_abnormal_limbs/digits/tail_de1.30858113
58MP0002102_abnormal_ear_morphology1.28937986
59MP0010307_abnormal_tumor_latency1.25890690
60MP0003045_fibrosis1.25011099
61MP0000383_abnormal_hair_follicle1.24602768
62MP0002092_abnormal_eye_morphology1.23467506
63MP0002084_abnormal_developmental_patter1.22764821
64MP0004134_abnormal_chest_morphology1.22568039
65MP0003941_abnormal_skin_development1.21230082
66MP0000579_abnormal_nail_morphology1.19993750
67MP0001501_abnormal_sleep_pattern1.17955666
68MP0005551_abnormal_eye_electrophysiolog1.16697014
69MP0001177_atelectasis1.16346976
70MP0004924_abnormal_behavior1.15149091
71MP0005386_behavior/neurological_phenoty1.15149091
72MP0010678_abnormal_skin_adnexa1.13929240
73MP0004084_abnormal_cardiac_muscle1.13870576
74MP0003385_abnormal_body_wall1.13475550
75MP0006072_abnormal_retinal_apoptosis1.12928607
76MP0003755_abnormal_palate_morphology1.12878322
77MP0009053_abnormal_anal_canal1.12773945
78MP0000534_abnormal_ureter_morphology1.12510997
79MP0003115_abnormal_respiratory_system1.12191575
80MP0002882_abnormal_neuron_morphology1.11908736
81MP0003938_abnormal_ear_development1.11763792
82MP0000955_abnormal_spinal_cord1.11756706
83MP0004197_abnormal_fetal_growth/weight/1.11730495
84MP0000566_synostosis1.10357139
85MP0000372_irregular_coat_pigmentation1.10234471
86MP0002088_abnormal_embryonic_growth/wei1.09964985
87MP0003984_embryonic_growth_retardation1.09580539
88MP0002751_abnormal_autonomic_nervous1.09157824
89MP0002086_abnormal_extraembryonic_tissu1.09015788
90MP0001502_abnormal_circadian_rhythm1.08967721
91MP0009250_abnormal_appendicular_skeleto1.08909320
92MP0002177_abnormal_outer_ear1.07503111
93MP0006292_abnormal_olfactory_placode1.07286568
94MP0004808_abnormal_hematopoietic_stem1.07207779
95MP0001348_abnormal_lacrimal_gland1.06652766
96MP0000427_abnormal_hair_cycle1.03673079
97MP0001286_abnormal_eye_development1.03324485
98MP0010386_abnormal_urinary_bladder1.02678200
99MP0005499_abnormal_olfactory_system1.02461382
100MP0005394_taste/olfaction_phenotype1.02461382
101MP0002736_abnormal_nociception_after1.01662628
102MP0003890_abnormal_embryonic-extraembry1.01466278
103MP0002233_abnormal_nose_morphology1.00759036
104MP0001485_abnormal_pinna_reflex0.97669671
105MP0008438_abnormal_cutaneous_collagen0.97259282
106MP0002733_abnormal_thermal_nociception0.97035436
107MP0001672_abnormal_embryogenesis/_devel0.96659702
108MP0005380_embryogenesis_phenotype0.96659702
109MP0001970_abnormal_pain_threshold0.95852360
110MP0002089_abnormal_postnatal_growth/wei0.95257241
111MP0000767_abnormal_smooth_muscle0.94694880
112MP0001346_abnormal_lacrimal_gland0.94614573
113MP0000026_abnormal_inner_ear0.94249012
114MP0000377_abnormal_hair_follicle0.94187550
115MP0002925_abnormal_cardiovascular_devel0.93321791
116MP0004185_abnormal_adipocyte_glucose0.92826535
117MP0008789_abnormal_olfactory_epithelium0.92499794
118MP0003300_gastrointestinal_ulcer0.91841437
119MP0009697_abnormal_copulation0.91130758
120MP0001963_abnormal_hearing_physiology0.90842593
121MP0003828_pulmonary_edema0.90726437
122MP0005623_abnormal_meninges_morphology0.90669743
123MP0002108_abnormal_muscle_morphology0.90217222
124MP0004885_abnormal_endolymph0.89960188
125MP0004264_abnormal_extraembryonic_tissu0.89730296
126MP0002822_catalepsy0.89127623
127MP0005253_abnormal_eye_physiology0.88982678
128MP0010368_abnormal_lymphatic_system0.87677767
129MP0002752_abnormal_somatic_nervous0.87576342
130MP0003942_abnormal_urinary_system0.86732286
131MP0002081_perinatal_lethality0.86641844
132MP0002152_abnormal_brain_morphology0.86514011
133MP0000462_abnormal_digestive_system0.86354502
134MP0003935_abnormal_craniofacial_develop0.86223858
135MP0009703_decreased_birth_body0.85627147
136MP0008057_abnormal_DNA_replication0.85468987
137MP0001915_intracranial_hemorrhage0.84865798
138MP0010630_abnormal_cardiac_muscle0.84349689
139MP0000049_abnormal_middle_ear0.84204013
140MP0001697_abnormal_embryo_size0.83512561
141MP0001293_anophthalmia0.83168627
142MP0003861_abnormal_nervous_system0.82959556
143MP0000920_abnormal_myelination0.82366610
144MP0002896_abnormal_bone_mineralization0.81460461
145MP0002085_abnormal_embryonic_tissue0.81300375
146MP0002638_abnormal_pupillary_reflex0.81290444
147MP0005621_abnormal_cell_physiology0.80607839
148MP0002116_abnormal_craniofacial_bone0.79516495
149MP0008569_lethality_at_weaning0.78475496
150MP0003077_abnormal_cell_cycle0.78396229
151MP0004811_abnormal_neuron_physiology0.78332038
152MP0002166_altered_tumor_susceptibility0.78197412
153MP0002098_abnormal_vibrissa_morphology0.77514517
154MP0003943_abnormal_hepatobiliary_system0.77263029
155MP0005248_abnormal_Harderian_gland0.77093306
156MP0005257_abnormal_intraocular_pressure0.76245613
157MP0002876_abnormal_thyroid_physiology0.76218249
158MP0003453_abnormal_keratinocyte_physiol0.74652649
159MP0000432_abnormal_head_morphology0.74530505
160MP0000350_abnormal_cell_proliferation0.74022543
161MP0001730_embryonic_growth_arrest0.73373945
162MP0004036_abnormal_muscle_relaxation0.71937046
163MP0003690_abnormal_glial_cell0.71781596
164MP0000516_abnormal_urinary_system0.71708967
165MP0005367_renal/urinary_system_phenotyp0.71708967
166MP0004130_abnormal_muscle_cell0.70922842
167MP0002938_white_spotting0.70621754
168MP0002066_abnormal_motor_capabilities/c0.70538754
169MP0000749_muscle_degeneration0.70157879
170MP0001943_abnormal_respiration0.69952674
171MP0008961_abnormal_basal_metabolism0.68174313

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)3.67098991
2Arterial tortuosity (HP:0005116)3.39756504
3Curly hair (HP:0002212)3.16148036
4Focal motor seizures (HP:0011153)3.02395224
5Overgrowth (HP:0001548)2.99843159
6Vertebral arch anomaly (HP:0008438)2.89727088
7Dysmetric saccades (HP:0000641)2.84885324
8Vascular tortuosity (HP:0004948)2.84885316
9Atonic seizures (HP:0010819)2.82921098
10Focal seizures (HP:0007359)2.78793072
11Abnormality of the nasal septum (HP:0000419)2.77362537
12Subacute progressive viral hepatitis (HP:0006572)2.74556080
13Excessive salivation (HP:0003781)2.69979484
14Drooling (HP:0002307)2.69979484
15Heterotopia (HP:0002282)2.69423510
16Relative macrocephaly (HP:0004482)2.58826657
17Absent speech (HP:0001344)2.57503018
18Aqueductal stenosis (HP:0002410)2.55312499
19Cubitus valgus (HP:0002967)2.54462852
20Cystic hygroma (HP:0000476)2.53977490
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.45145687
22Degeneration of the lateral corticospinal tracts (HP:0002314)2.45145687
23Blue irides (HP:0000635)2.44979375
24Thyroid carcinoma (HP:0002890)2.44891606
25Subaortic stenosis (HP:0001682)2.43884992
26Abnormality of the left ventricular outflow tract (HP:0011103)2.43884992
27Epileptic encephalopathy (HP:0200134)2.42551726
28Progressive cerebellar ataxia (HP:0002073)2.42225254
29Broad-based gait (HP:0002136)2.40350021
30Protruding tongue (HP:0010808)2.39631188
31Deep philtrum (HP:0002002)2.36720378
32Widely spaced teeth (HP:0000687)2.31519102
33Large earlobe (HP:0009748)2.26821127
34Exotropia (HP:0000577)2.26714479
35Absent frontal sinuses (HP:0002688)2.26432087
36Oligodactyly (hands) (HP:0001180)2.21118800
37Bladder neoplasm (HP:0009725)2.17612539
38Bladder carcinoma (HP:0002862)2.17612539
39Transitional cell carcinoma of the bladder (HP:0006740)2.17239705
40Hepatoblastoma (HP:0002884)2.16598567
41Abnormality of incisor morphology (HP:0011063)2.15711915
42Aplasia involving bones of the upper limbs (HP:0009823)2.15648778
43Aplasia of the phalanges of the hand (HP:0009802)2.15648778
44Aplasia involving bones of the extremities (HP:0009825)2.15648778
45Midline defect of the nose (HP:0004122)2.14459451
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12808735
47Short 4th metacarpal (HP:0010044)2.12808735
48Abnormality of salivation (HP:0100755)2.10906545
49Cupped ear (HP:0000378)2.09855073
50Volvulus (HP:0002580)2.09667892
51Mixed hearing impairment (HP:0000410)2.08303972
52Truncal obesity (HP:0001956)2.05637592
53Mitral valve prolapse (HP:0001634)2.04572746
54Hyperventilation (HP:0002883)2.03369697
55Difficulty running (HP:0009046)2.03195997
56Lip pit (HP:0100267)2.02169106
57Abnormality of the corticospinal tract (HP:0002492)2.01962129
58Ankyloglossia (HP:0010296)1.96789280
59Germ cell neoplasia (HP:0100728)1.96504230
60Gaze-evoked nystagmus (HP:0000640)1.95161863
61Chin dimple (HP:0010751)1.94219824
62Abnormality of the distal phalanx of the thumb (HP:0009617)1.93548884
63Macroorchidism (HP:0000053)1.93499821
64Tubulointerstitial nephritis (HP:0001970)1.92792854
65Fair hair (HP:0002286)1.92689775
66Generalized hypopigmentation of hair (HP:0011358)1.92073619
67Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90623754
68Cutaneous finger syndactyly (HP:0010554)1.89582494
69Sandal gap (HP:0001852)1.89244414
70Short chin (HP:0000331)1.89187611
71Leiomyosarcoma (HP:0100243)1.88948126
72Uterine leiomyosarcoma (HP:0002891)1.88948126
73High anterior hairline (HP:0009890)1.87172731
74Neonatal hypoglycemia (HP:0001998)1.85117859
75Pheochromocytoma (HP:0002666)1.84749079
76Papillary thyroid carcinoma (HP:0002895)1.83921843
77Smooth philtrum (HP:0000319)1.83473996
78Submucous cleft hard palate (HP:0000176)1.82510661
79Acute myeloid leukemia (HP:0004808)1.80224515
80Action tremor (HP:0002345)1.79790989
81Aortic dissection (HP:0002647)1.79340097
82Prostate neoplasm (HP:0100787)1.77570099
83Bell-shaped thorax (HP:0001591)1.76659980
84Absence seizures (HP:0002121)1.76480648
85Intellectual disability, moderate (HP:0002342)1.74986544
86Cutaneous syndactyly (HP:0012725)1.74892043
87Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74719442
88Abnormality of chromosome segregation (HP:0002916)1.73877655
89Missing ribs (HP:0000921)1.73476666
90Tapered finger (HP:0001182)1.73394883
91Astrocytoma (HP:0009592)1.73344539
92Abnormality of the astrocytes (HP:0100707)1.73344539
93Decreased lacrimation (HP:0000633)1.73122755
94Medial flaring of the eyebrow (HP:0010747)1.72954174
95Alacrima (HP:0000522)1.72337735
96Hypoplasia of the iris (HP:0007676)1.71969567
97Morphological abnormality of the middle ear (HP:0008609)1.71496351
98Thick eyebrow (HP:0000574)1.71122054
99Scanning speech (HP:0002168)1.70938317
100Truncal ataxia (HP:0002078)1.70894512
101Gait imbalance (HP:0002141)1.70651841
102Inappropriate behavior (HP:0000719)1.70331333
103Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.70033566
104Asymmetry of the thorax (HP:0001555)1.69601690
105Aplasia cutis congenita (HP:0001057)1.68991604
106Medulloblastoma (HP:0002885)1.68956444
107Anteriorly placed anus (HP:0001545)1.68242768
108Termporal pattern (HP:0011008)1.68006217
109Insidious onset (HP:0003587)1.68006217
110Gastroesophageal reflux (HP:0002020)1.67155291
111Urinary bladder sphincter dysfunction (HP:0002839)1.66695572
112Abnormality of the frontal sinuses (HP:0002687)1.66671554
113Malignant gastrointestinal tract tumors (HP:0006749)1.65764412
114Gastrointestinal carcinoma (HP:0002672)1.65764412
115Dental malocclusion (HP:0000689)1.65602617
116Dialeptic seizures (HP:0011146)1.65538640
117Short foot (HP:0001773)1.65073716
118Tented upper lip vermilion (HP:0010804)1.64295281
119Deeply set eye (HP:0000490)1.64283863
120Abnormality of the labia minora (HP:0012880)1.62633458
121Neoplasm of the heart (HP:0100544)1.61320736
122Abnormality of the lower motor neuron (HP:0002366)1.61299865
123Aortic aneurysm (HP:0004942)1.61023922
124Hypoplastic ischia (HP:0003175)1.60762608
125Coarse hair (HP:0002208)1.60663342
126Genital tract atresia (HP:0001827)1.60355689
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.60096168
128Thickened helices (HP:0000391)1.59945682
129Abnormal hair whorl (HP:0010721)1.59735346
130Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59453718
131Absent/shortened dynein arms (HP:0200106)1.59188332
132Dynein arm defect of respiratory motile cilia (HP:0012255)1.59188332
133Urinary urgency (HP:0000012)1.57780192
134Intestinal atresia (HP:0011100)1.56741993
135Increased mean platelet volume (HP:0011877)1.56650378
136Open mouth (HP:0000194)1.56342772
137Stomach cancer (HP:0012126)1.55943133
138Aplasia/Hypoplasia of the lens (HP:0008063)1.55191116
139Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.54778854
140Absent eyebrow (HP:0002223)1.54766872
141Congenital primary aphakia (HP:0007707)1.54437173
142Broad ribs (HP:0000885)1.54203524
143Obsessive-compulsive behavior (HP:0000722)1.53788358
144Genetic anticipation (HP:0003743)1.53545997
145Omphalocele (HP:0001539)1.52901136
146Syringomyelia (HP:0003396)1.52824833
147Spinal cord lesions (HP:0100561)1.52824833
148Fibrous tissue neoplasm (HP:0012316)1.52236977
149Pulmonic stenosis (HP:0001642)1.52186082
150Low anterior hairline (HP:0000294)1.52101516
151Labial hypoplasia (HP:0000066)1.52046660
152Right ventricular cardiomyopathy (HP:0011663)1.51632949
153Vaginal atresia (HP:0000148)1.51555895
154Impaired vibration sensation in the lower limbs (HP:0002166)1.51210264
155Lower limb muscle weakness (HP:0007340)1.50728356
156Long eyelashes (HP:0000527)1.50654264
157Abnormality of the renal medulla (HP:0100957)1.50516540
158Calf muscle hypertrophy (HP:0008981)1.50375183
159Hypopigmentation of the fundus (HP:0007894)1.50339585
160Menstrual irregularities (HP:0000858)1.50233182
161Long nose (HP:0003189)1.49377579
162Rhabdomyosarcoma (HP:0002859)1.49255391
163Narrow palate (HP:0000189)1.48784365
164Limited hip movement (HP:0008800)1.48518275
165Generalized tonic-clonic seizures (HP:0002069)1.48434443
166Abnormality of oral frenula (HP:0000190)1.48189681
167Glioma (HP:0009733)1.47723809
168Neoplasm of the adrenal cortex (HP:0100641)1.47563083
169Conjunctival telangiectasia (HP:0000524)1.47476877
170Amblyopia (HP:0000646)1.46907507
171Nephronophthisis (HP:0000090)1.46570222
172Abnormality of the epiphyses of the hand (HP:0005924)1.46181994
173Abnormality of the ischium (HP:0003174)1.46174278
174Exostoses (HP:0100777)1.45231011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.68936567
2NTRK32.86085555
3TNIK2.69504532
4EPHA42.41318674
5SCYL22.30872998
6MAP3K42.09034271
7FGFR22.07557562
8STK38L2.06510994
9PDGFRA2.05570244
10FRK2.02738867
11MAP2K71.96969066
12MARK11.95089443
13PKN21.87833676
14MAPK131.85366694
15PNCK1.84222418
16BCR1.80830364
17NUAK11.76752032
18MAP3K101.75699085
19CAMK1G1.72751812
20LATS21.71914308
21BRD41.68871656
22ICK1.67215724
23MKNK21.62395410
24INSRR1.62034680
25ZAK1.61709042
26STK391.58429504
27NEK91.57350783
28NEK61.52873082
29PLK21.46248907
30SGK21.46069890
31PRPF4B1.45451166
32LATS11.43002441
33AKT31.40937374
34RIPK41.39112452
35ERBB31.39058277
36EEF2K1.33992814
37MAP3K61.28907474
38PKN11.27421762
39BMPR21.25756555
40KSR11.25722275
41CDK61.25567426
42NTRK21.25316704
43BMPR1B1.24997539
44WNK11.23395226
45STK241.22011424
46SGK2231.19159300
47SGK4941.19159300
48YES11.18910568
49TAF11.15877427
50FGR1.13532915
51RET1.10934077
52MET1.05713951
53OXSR11.05426389
54BRSK21.03272059
55SGK11.02226283
56PIK3CA1.01183887
57CAMK1D1.00991909
58DMPK1.00144056
59PRKCE0.99725742
60MAP3K20.99086260
61MAP2K40.97522716
62MTOR0.96254625
63MAP3K90.95602276
64GRK70.93014244
65TTN0.92480584
66SGK30.91545477
67CDK30.91391098
68NLK0.91228805
69SIK30.89593617
70MINK10.89287598
71WNK30.86134237
72PAK30.83940684
73STK380.83197374
74MKNK10.82678044
75CDK50.80908526
76FGFR30.80237924
77TYRO30.78902694
78EPHB20.78220084
79SIK20.77981503
80CAMK2A0.77888808
81CSNK1A1L0.76890407
82PAK60.76399610
83DYRK1A0.73152921
84FLT30.73127128
85CCNB10.71873164
86KSR20.70355314
87UHMK10.69900961
88EIF2AK20.69188323
89MAP3K70.68051959
90MST1R0.67258122
91CDK120.66744969
92PDGFRB0.66587690
93MELK0.65786086
94CAMK2B0.64181206
95PAK20.63898178
96ERBB40.61436110
97CDC42BPA0.61420512
98FER0.61342230
99NTRK10.60534681
100PRKCQ0.59981979
101EPHA30.59623766
102DDR20.59268299
103JAK10.59000769
104CDK90.57349502
105PRKG10.55977132
106MAPK100.55276921
107MARK20.53571210
108PRKCG0.51633873
109STK110.51367876
110CAMK2D0.51277049
111IRAK20.50657521
112TRPM70.49761449
113CSNK1G20.49191210
114ADRBK10.48311299
115ADRBK20.47125861
116ROCK10.46751474
117PRKCH0.45172652
118IRAK10.44764292
119EIF2AK30.44572611
120STK30.44088849
121ROCK20.43883490
122GSK3B0.43687198
123RPS6KB20.43041640
124RAF10.42686871
125MAPK70.42667074
126RIPK10.41740243
127CAMKK20.41703827
128CSNK1D0.41536261
129PTK20.41255196
130MAP3K140.40668144
131RPS6KB10.39713085
132FGFR10.39599842
133MARK30.39254312
134RPS6KA30.38966292
135HIPK20.38406316
136PRKCB0.37644061
137TEC0.37220204
138FYN0.36581526
139CDK80.36474539
140FGFR40.36209238
141EGFR0.35854830
142MAP3K50.34861536
143ATM0.34131943
144SIK10.33942243

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.76643309
2Chronic myeloid leukemia_Homo sapiens_hsa052201.96548914
3Glutamatergic synapse_Homo sapiens_hsa047241.88760824
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86789698
5Morphine addiction_Homo sapiens_hsa050321.86194163
6Non-small cell lung cancer_Homo sapiens_hsa052231.75144162
7Pancreatic cancer_Homo sapiens_hsa052121.73495858
8Circadian entrainment_Homo sapiens_hsa047131.73058829
9Axon guidance_Homo sapiens_hsa043601.69996264
10Taste transduction_Homo sapiens_hsa047421.66418797
11Long-term potentiation_Homo sapiens_hsa047201.63912459
12Amphetamine addiction_Homo sapiens_hsa050311.62080207
13Serotonergic synapse_Homo sapiens_hsa047261.60907902
14GABAergic synapse_Homo sapiens_hsa047271.55320211
15Phototransduction_Homo sapiens_hsa047441.53922198
16Olfactory transduction_Homo sapiens_hsa047401.51804281
17Thyroid cancer_Homo sapiens_hsa052161.47625751
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.46173755
19Salivary secretion_Homo sapiens_hsa049701.45157807
20Long-term depression_Homo sapiens_hsa047301.41991025
21Renin secretion_Homo sapiens_hsa049241.41189817
22Dopaminergic synapse_Homo sapiens_hsa047281.41095778
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40805138
24Small cell lung cancer_Homo sapiens_hsa052221.37954162
25Prolactin signaling pathway_Homo sapiens_hsa049171.36826824
26Cholinergic synapse_Homo sapiens_hsa047251.36787121
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.33284504
28Insulin secretion_Homo sapiens_hsa049111.31512405
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30179803
30Type II diabetes mellitus_Homo sapiens_hsa049301.28648797
31Oxytocin signaling pathway_Homo sapiens_hsa049211.24376391
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23108410
33Calcium signaling pathway_Homo sapiens_hsa040201.18471086
34Cocaine addiction_Homo sapiens_hsa050301.17063059
35ErbB signaling pathway_Homo sapiens_hsa040121.15461267
36cAMP signaling pathway_Homo sapiens_hsa040241.12861419
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12138317
38Dorso-ventral axis formation_Homo sapiens_hsa043201.11898605
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11358959
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10314967
41Synaptic vesicle cycle_Homo sapiens_hsa047211.09746764
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09071006
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07643390
44GnRH signaling pathway_Homo sapiens_hsa049121.06702844
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05740015
46Platelet activation_Homo sapiens_hsa046111.03357351
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03288003
48Alcoholism_Homo sapiens_hsa050341.02639890
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02314179
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01383967
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01056909
52Gastric acid secretion_Homo sapiens_hsa049711.00909799
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00535943
54Wnt signaling pathway_Homo sapiens_hsa043101.00482967
55Choline metabolism in cancer_Homo sapiens_hsa052310.98811000
56Acute myeloid leukemia_Homo sapiens_hsa052210.98534715
57Melanogenesis_Homo sapiens_hsa049160.98264819
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97767824
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97079552
60VEGF signaling pathway_Homo sapiens_hsa043700.96249194
61Gap junction_Homo sapiens_hsa045400.94994503
62Insulin signaling pathway_Homo sapiens_hsa049100.94684897
63Glioma_Homo sapiens_hsa052140.94515334
64Cell cycle_Homo sapiens_hsa041100.93875903
65B cell receptor signaling pathway_Homo sapiens_hsa046620.93716669
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.92248797
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92225906
68MAPK signaling pathway_Homo sapiens_hsa040100.92140651
69Dilated cardiomyopathy_Homo sapiens_hsa054140.91072882
70AMPK signaling pathway_Homo sapiens_hsa041520.86549126
71Ras signaling pathway_Homo sapiens_hsa040140.85307116
72Circadian rhythm_Homo sapiens_hsa047100.85052385
73ECM-receptor interaction_Homo sapiens_hsa045120.84910009
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.84593194
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83987264
76Ether lipid metabolism_Homo sapiens_hsa005650.83349306
77Lysine degradation_Homo sapiens_hsa003100.83289274
78Adherens junction_Homo sapiens_hsa045200.83218762
79Prostate cancer_Homo sapiens_hsa052150.82493678
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81893739
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.81265642
82Melanoma_Homo sapiens_hsa052180.80908839
83Amoebiasis_Homo sapiens_hsa051460.78828800
84Notch signaling pathway_Homo sapiens_hsa043300.78803330
85Estrogen signaling pathway_Homo sapiens_hsa049150.77914579
86MicroRNAs in cancer_Homo sapiens_hsa052060.77897490
87Inositol phosphate metabolism_Homo sapiens_hsa005620.77712359
88Hepatitis B_Homo sapiens_hsa051610.77682770
89mRNA surveillance pathway_Homo sapiens_hsa030150.77306686
90Hedgehog signaling pathway_Homo sapiens_hsa043400.72857047
91Insulin resistance_Homo sapiens_hsa049310.72722281
92Ovarian steroidogenesis_Homo sapiens_hsa049130.72647429
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72418373
94Focal adhesion_Homo sapiens_hsa045100.71877324
95Endometrial cancer_Homo sapiens_hsa052130.71769940
96Renal cell carcinoma_Homo sapiens_hsa052110.71520800
97Basal cell carcinoma_Homo sapiens_hsa052170.70976239
98Rap1 signaling pathway_Homo sapiens_hsa040150.69997741
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68382802
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68364178
101Systemic lupus erythematosus_Homo sapiens_hsa053220.67564981
102Bladder cancer_Homo sapiens_hsa052190.67312534
103Viral carcinogenesis_Homo sapiens_hsa052030.66841968
104Oocyte meiosis_Homo sapiens_hsa041140.66687756
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66575850
106TGF-beta signaling pathway_Homo sapiens_hsa043500.66035522
107Autoimmune thyroid disease_Homo sapiens_hsa053200.65524837
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64944592
109Collecting duct acid secretion_Homo sapiens_hsa049660.64850811
110Colorectal cancer_Homo sapiens_hsa052100.64615518
111African trypanosomiasis_Homo sapiens_hsa051430.64552199
112Hepatitis C_Homo sapiens_hsa051600.64535857
113p53 signaling pathway_Homo sapiens_hsa041150.63097751
114Sphingolipid metabolism_Homo sapiens_hsa006000.62439146
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62321574
116Pancreatic secretion_Homo sapiens_hsa049720.62107239
117FoxO signaling pathway_Homo sapiens_hsa040680.60820313
118Chemokine signaling pathway_Homo sapiens_hsa040620.60542580
119Proteoglycans in cancer_Homo sapiens_hsa052050.59947224
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.59909034
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59847782
122Rheumatoid arthritis_Homo sapiens_hsa053230.59242853
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58609745
124Hippo signaling pathway_Homo sapiens_hsa043900.58347485
125T cell receptor signaling pathway_Homo sapiens_hsa046600.57921720
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57852569
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57565325
128Tight junction_Homo sapiens_hsa045300.57330484
129Thyroid hormone synthesis_Homo sapiens_hsa049180.56913303
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52021757
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51724280
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47781069
133Pathways in cancer_Homo sapiens_hsa052000.47475218
134mTOR signaling pathway_Homo sapiens_hsa041500.47243207

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