RCAN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)5.60477406
2cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.30599179
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.97660684
4cell aggregation (GO:0098743)4.66038437
5cartilage condensation (GO:0001502)4.66038437
6hemidesmosome assembly (GO:0031581)4.55001549
7plasma membrane repair (GO:0001778)4.52369140
8muscle filament sliding (GO:0030049)4.46644895
9actin-myosin filament sliding (GO:0033275)4.46644895
10sarcomere organization (GO:0045214)4.39638189
11chondrocyte development (GO:0002063)4.38035630
12cardiac myofibril assembly (GO:0055003)4.32371339
13notochord development (GO:0030903)4.21761404
14negative regulation of potassium ion transmembrane transport (GO:1901380)4.15012094
15actin-mediated cell contraction (GO:0070252)3.91118291
16myofibril assembly (GO:0030239)3.88295162
17cell adhesion mediated by integrin (GO:0033627)3.85312677
18regulation of membrane protein ectodomain proteolysis (GO:0051043)3.84614032
19regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.79318629
20endothelial cell morphogenesis (GO:0001886)3.77452584
21cardiac muscle tissue morphogenesis (GO:0055008)3.63435751
22desmosome organization (GO:0002934)3.60959874
23negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.60783876
24chondrocyte proliferation (GO:0035988)3.60491109
25collagen fibril organization (GO:0030199)3.58475136
26limb bud formation (GO:0060174)3.54705646
27regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.52613564
28atrioventricular valve morphogenesis (GO:0003181)3.43089732
29fibrinolysis (GO:0042730)3.38256903
30positive regulation of p38MAPK cascade (GO:1900745)3.37918607
31muscle tissue morphogenesis (GO:0060415)3.36082992
32ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.29516003
33positive regulation of extracellular matrix organization (GO:1903055)3.28378911
34regulation of skeletal muscle contraction (GO:0014819)3.28285045
35cardiac muscle contraction (GO:0060048)3.28125233
36regulation of p38MAPK cascade (GO:1900744)3.25718618
37cardiac muscle cell development (GO:0055013)3.23895092
38bundle of His cell to Purkinje myocyte communication (GO:0086069)3.20070925
39cellular response to vitamin D (GO:0071305)3.18466128
40positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.15140609
41cellular glucuronidation (GO:0052695)3.11297268
42cellular response to vitamin (GO:0071295)3.10840253
43endocardial cushion morphogenesis (GO:0003203)3.08936561
44regulation of cardioblast differentiation (GO:0051890)3.07907682
45cardiac cell development (GO:0055006)3.07092521
46sodium ion export (GO:0071436)3.06200667
47actin filament-based movement (GO:0030048)3.05856422
48regulation of early endosome to late endosome transport (GO:2000641)3.05813549
49endochondral ossification (GO:0001958)3.05480990
50replacement ossification (GO:0036075)3.05480990
51heart trabecula formation (GO:0060347)2.98854886
52actomyosin structure organization (GO:0031032)2.97564028
53response to lead ion (GO:0010288)2.96607658
54cellular copper ion homeostasis (GO:0006878)2.94943847
55cellular response to zinc ion (GO:0071294)2.93999218
56ventricular cardiac muscle cell action potential (GO:0086005)2.92707978
57regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.91385315
58adhesion of symbiont to host cell (GO:0044650)2.91104789
59virion attachment to host cell (GO:0019062)2.91104789
60striated muscle hypertrophy (GO:0014897)2.90380294
61cardiac muscle hypertrophy (GO:0003300)2.89464624
62cellular response to interferon-alpha (GO:0035457)2.88397272
63substrate-dependent cell migration (GO:0006929)2.87788229
64tooth mineralization (GO:0034505)2.84454334
65peptidyl-proline hydroxylation (GO:0019511)2.83985318
66peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.83114751
67heart valve morphogenesis (GO:0003179)2.82471143
68regulation of vitamin D biosynthetic process (GO:0060556)2.81995942
69protein hydroxylation (GO:0018126)2.81889395
70uronic acid metabolic process (GO:0006063)2.81589117
71glucuronate metabolic process (GO:0019585)2.81589117
72striated muscle contraction (GO:0006941)2.80746230
73positive regulation of astrocyte differentiation (GO:0048711)2.80704016
74endodermal cell differentiation (GO:0035987)2.74507734
75response to vitamin D (GO:0033280)2.73427486
76apoptotic cell clearance (GO:0043277)2.72919474
77positive regulation of cartilage development (GO:0061036)2.72516367
78regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.69454965
79negative regulation of striated muscle cell apoptotic process (GO:0010664)2.69334319
80barbed-end actin filament capping (GO:0051016)2.68259075
81collagen metabolic process (GO:0032963)2.66348674
82collagen catabolic process (GO:0030574)2.66261491
83regulation of sarcomere organization (GO:0060297)2.65737306
84mesenchymal-epithelial cell signaling (GO:0060638)2.64764344
85regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.64722341
86protein localization to endosome (GO:0036010)2.63469205
87cellular potassium ion homeostasis (GO:0030007)2.60836133
88proteoglycan metabolic process (GO:0006029)2.60731462
89tricarboxylic acid cycle (GO:0006099)2.59359366
90regulation of integrin-mediated signaling pathway (GO:2001044)2.57076222
91skin morphogenesis (GO:0043589)2.54891211
92retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54541166
93vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54379879
94carnitine shuttle (GO:0006853)2.53762972
95cartilage development (GO:0051216)2.53389706
96decidualization (GO:0046697)2.53156873
97regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.53007303
98cell communication involved in cardiac conduction (GO:0086065)2.52291803
99regulation of the force of heart contraction (GO:0002026)2.52177493
100sarcoplasmic reticulum calcium ion transport (GO:0070296)2.51928863
101multicellular organismal macromolecule metabolic process (GO:0044259)2.51849919
102negative regulation of coagulation (GO:0050819)2.50871915
103regulation of actin filament-based movement (GO:1903115)2.50843022
104muscle hypertrophy (GO:0014896)2.50496273
105adhesion of symbiont to host (GO:0044406)2.50248532
106lysine catabolic process (GO:0006554)2.49918259
107lysine metabolic process (GO:0006553)2.49918259
108UDP-N-acetylglucosamine metabolic process (GO:0006047)2.49151209
1094-hydroxyproline metabolic process (GO:0019471)2.48605343
110regulation of transforming growth factor beta1 production (GO:0032908)2.47801938
111negative regulation of wound healing (GO:0061045)2.47778431
112multicellular organismal catabolic process (GO:0044243)2.47355906
113positive regulation of chondrocyte differentiation (GO:0032332)2.46848757
114negative regulation of potassium ion transport (GO:0043267)2.46833160
115extracellular matrix disassembly (GO:0022617)2.46286304
116mesenchyme morphogenesis (GO:0072132)2.46128938
117hypotonic response (GO:0006971)2.46122237
118keratan sulfate biosynthetic process (GO:0018146)2.45620085
119regulation of apoptotic process involved in morphogenesis (GO:1902337)2.45244673
120regulation of mononuclear cell migration (GO:0071675)2.44188727
121melanin biosynthetic process (GO:0042438)2.43948632
122glomerular basement membrane development (GO:0032836)2.43384929
123cellular response to cadmium ion (GO:0071276)2.42889570
124fatty acid transmembrane transport (GO:1902001)2.42861017
125negative regulation of heart growth (GO:0061117)2.41962701
126negative regulation of cardiac muscle tissue growth (GO:0055022)2.41962701
127type B pancreatic cell proliferation (GO:0044342)2.41883283
128multicellular organismal metabolic process (GO:0044236)2.41538224
129vascular endothelial growth factor signaling pathway (GO:0038084)2.41357971
130negative regulation of lipase activity (GO:0060192)2.40673091
131regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.40661704
132iron ion import (GO:0097286)2.40321558
133negative regulation of protein localization to cell surface (GO:2000009)2.40265171
134response to gravity (GO:0009629)2.39838907
135ventricular cardiac muscle cell development (GO:0055015)2.39635843
136chondrocyte differentiation (GO:0002062)2.39026007
137regulation of plasminogen activation (GO:0010755)2.38456603
138negative regulation of homotypic cell-cell adhesion (GO:0034111)2.37924678
139regulation of extracellular matrix disassembly (GO:0010715)2.37771611
140regulation of relaxation of muscle (GO:1901077)2.37637663
141kidney mesenchyme development (GO:0072074)2.36503827
142ER overload response (GO:0006983)2.36386017
143cell-substrate junction assembly (GO:0007044)2.36366574
144positive regulation of odontogenesis (GO:0042482)2.36176201
145regulation of vitamin metabolic process (GO:0030656)2.36033767
146substrate adhesion-dependent cell spreading (GO:0034446)2.35675972
147response to BMP (GO:0071772)2.35446404
148cellular response to BMP stimulus (GO:0071773)2.35446404
149cell migration involved in heart development (GO:0060973)2.34910281
150amino-acid betaine transport (GO:0015838)2.34703940
151negative regulation of blood coagulation (GO:0030195)2.34475178
152negative regulation of hemostasis (GO:1900047)2.34475178
153positive regulation of blood vessel endothelial cell migration (GO:0043536)2.31974182
154extracellular matrix assembly (GO:0085029)2.31346283
155maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.30171542
156response to cadmium ion (GO:0046686)2.24167686
157regulation of cytokine secretion involved in immune response (GO:0002739)2.21966556
158positive regulation of calcium ion import (GO:0090280)2.21917005
159chondroitin sulfate catabolic process (GO:0030207)2.20724708
160sequestering of extracellular ligand from receptor (GO:0035581)2.20656268
161positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.19469294
162metanephric mesenchyme development (GO:0072075)2.18824927
163platelet-derived growth factor receptor signaling pathway (GO:0048008)2.18070341
164positive regulation of positive chemotaxis (GO:0050927)2.17954859
165lymphangiogenesis (GO:0001946)2.16453753
166regulation of axon extension involved in axon guidance (GO:0048841)2.15575827
167wound healing, spreading of epidermal cells (GO:0035313)2.15236308
168epithelial cell-cell adhesion (GO:0090136)2.14967436
169Rac protein signal transduction (GO:0016601)2.14955533
170negative regulation of complement activation (GO:0045916)2.13550646
171regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.11565301
172positive regulation of osteoblast proliferation (GO:0033690)2.11534464
173regulation of positive chemotaxis (GO:0050926)2.11491872
174endothelial cell chemotaxis (GO:0035767)2.10267625
175positive regulation of receptor recycling (GO:0001921)2.10265325
176response to parathyroid hormone (GO:0071107)2.10181341
177positive regulation of chemokine biosynthetic process (GO:0045080)2.08594137
178extracellular fibril organization (GO:0043206)2.08506323
179neural crest cell development (GO:0014032)2.08226209
180negative regulation of platelet activation (GO:0010544)2.07691659
181positive regulation of axon extension (GO:0045773)2.07388361
182glial cell migration (GO:0008347)2.07265790
183basement membrane organization (GO:0071711)2.06466522
184melanin metabolic process (GO:0006582)2.06313873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.00509221
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.21696063
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.87755822
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.52588159
5* ESR2_21235772_ChIP-Seq_MCF-7_Human2.51158180
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.31439657
7* ESR1_21235772_ChIP-Seq_MCF-7_Human2.29002993
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26344956
9CLOCK_20551151_ChIP-Seq_293T_Human2.16994149
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.04628433
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04495385
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.96691660
13ESR1_20079471_ChIP-ChIP_T-47D_Human1.88769822
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88376325
15* AR_21572438_ChIP-Seq_LNCaP_Human1.84420767
16* CJUN_26792858_Chip-Seq_BT549_Human1.83251399
17* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77314906
18* BRD4_25478319_ChIP-Seq_HGPS_Human1.74583402
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71123268
20TBX20_22328084_ChIP-Seq_HEART_Mouse1.69682931
21TBX20_22080862_ChIP-Seq_HEART_Mouse1.69682931
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64062308
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.63827119
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60933286
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59465650
26ZNF263_19887448_ChIP-Seq_K562_Human1.58144082
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55770341
28LXR_22158963_ChIP-Seq_LIVER_Mouse1.51202327
29* RXR_22158963_ChIP-Seq_LIVER_Mouse1.48907707
30GATA1_22025678_ChIP-Seq_K562_Human1.48205675
31* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47265042
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45162963
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42995840
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42995840
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42943783
36TP53_16413492_ChIP-PET_HCT116_Human1.41719990
37* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39817490
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39686783
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39372288
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32437055
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.32365423
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30862778
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.30736749
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.29199473
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27750805
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27179867
47RXR_22108803_ChIP-Seq_LS180_Human1.26169320
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24472020
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23917573
50KDM2B_26808549_Chip-Seq_K562_Human1.23785980
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23690706
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22858816
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.22458367
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22333276
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21441449
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20852834
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.20368773
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19537007
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19401792
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19401792
61SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19394846
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19200514
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18428394
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16994822
65SOX2_20726797_ChIP-Seq_SW620_Human1.16842254
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16756166
67TP53_18474530_ChIP-ChIP_U2OS_Human1.16631257
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16456333
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.15591552
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15300449
71* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14058586
72* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13760016
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12717033
74P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11320031
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.11268602
76PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11113977
77* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11023474
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10010359
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10010359
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09680170
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09205542
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07380782
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07145059
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06486058
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04866748
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.04695957
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04065455
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03744639
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03576121
90ATF3_27146783_Chip-Seq_COLON_Human1.03044356
91EGR1_19032775_ChIP-ChIP_M12_Human1.03014298
92* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02460170
93GBX2_23144817_ChIP-Seq_PC3_Human1.02414177
94JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01723669
95* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00531149
96RACK7_27058665_Chip-Seq_MCF-7_Human0.99588410
97CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99330279
98P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99187254
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.99072079
100CDX2_20551321_ChIP-Seq_CACO-2_Human0.98416864
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97109182
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96548569
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96080015
104SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95609129
105TCF4_18268006_ChIP-ChIP_LS174T_Human0.95101317
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94966206
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93624823
108UBF1/2_26484160_Chip-Seq_HMECs_Human0.93271436
109EZH2_27294783_Chip-Seq_NPCs_Mouse0.93266574
110SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93181506
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92678058
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92066390
113ELK3_25401928_ChIP-Seq_HUVEC_Human0.92032563
114RNF2_27304074_Chip-Seq_ESCs_Mouse0.91564431
115MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91062603
116ISL1_27105846_Chip-Seq_CPCs_Mouse0.90924988
117AHR_22903824_ChIP-Seq_MCF-7_Human0.90808151
118TP63_23658742_ChIP-Seq_EP156T_Human0.90511560
119CMYC_18555785_Chip-Seq_ESCs_Mouse0.90501521
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.90271201
121NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90121143
122EZH2_27294783_Chip-Seq_ESCs_Mouse0.88750143
123ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88737893
124SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88016337
125WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87843636
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87656378
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87384680
128PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87308776
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86809932
130SMAD4_21799915_ChIP-Seq_A2780_Human0.86481418
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.85107885
132SA1_22415368_ChIP-Seq_MEFs_Mouse0.85038209
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84995440
134GATA3_24758297_ChIP-Seq_MCF-7_Human0.84054175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.41164429
2MP0000751_myopathy4.22055001
3MP0004084_abnormal_cardiac_muscle3.51106406
4MP0002837_dystrophic_cardiac_calcinosis3.32537825
5MP0000749_muscle_degeneration3.04924031
6MP0003705_abnormal_hypodermis_morpholog2.98630603
7MP0005171_absent_coat_pigmentation2.95699232
8MP0002282_abnormal_trachea_morphology2.72220014
9MP0005257_abnormal_intraocular_pressure2.65290870
10MP0005275_abnormal_skin_tensile2.63224648
11MP0000678_abnormal_parathyroid_gland2.56621564
12MP0004036_abnormal_muscle_relaxation2.52380654
13MP0005503_abnormal_tendon_morphology2.49298794
14MP0005330_cardiomyopathy2.33807184
15MP0004272_abnormal_basement_membrane2.32785709
16MP0004215_abnormal_myocardial_fiber2.21331514
17MP0002933_joint_inflammation2.20370446
18MP0004134_abnormal_chest_morphology2.19349115
19MP0002972_abnormal_cardiac_muscle2.16274521
20MP0000750_abnormal_muscle_regeneration2.15768905
21MP0002877_abnormal_melanocyte_morpholog2.15595793
22MP0008438_abnormal_cutaneous_collagen2.13307443
23MP0004087_abnormal_muscle_fiber2.09658604
24MP0005620_abnormal_muscle_contractility1.95474030
25MP0009250_abnormal_appendicular_skeleto1.90419756
26MP0008775_abnormal_heart_ventricle1.88362643
27MP0009780_abnormal_chondrocyte_physiolo1.84931541
28MP0005408_hypopigmentation1.84670321
29MP0000762_abnormal_tongue_morphology1.79601539
30MP0003566_abnormal_cell_adhesion1.78915863
31MP0000163_abnormal_cartilage_morphology1.74179416
32MP0006054_spinal_hemorrhage1.73471521
33MP0009384_cardiac_valve_regurgitation1.72347498
34MP0000747_muscle_weakness1.69043496
35MP0006138_congestive_heart_failure1.68657739
36MP0002106_abnormal_muscle_physiology1.66382417
37MP0002896_abnormal_bone_mineralization1.62652999
38MP0001544_abnormal_cardiovascular_syste1.60189853
39MP0005385_cardiovascular_system_phenoty1.60189853
40MP0005058_abnormal_lysosome_morphology1.52283358
41* MP0004484_altered_response_of1.51338047
42MP0010368_abnormal_lymphatic_system1.49277741
43MP0001958_emphysema1.47441185
44MP0005369_muscle_phenotype1.47103827
45MP0003279_aneurysm1.46945291
46MP0005197_abnormal_uvea_morphology1.46689161
47MP0003300_gastrointestinal_ulcer1.44992568
48MP0000759_abnormal_skeletal_muscle1.44955771
49MP0010630_abnormal_cardiac_muscle1.42827367
50MP0001299_abnormal_eye_distance/1.41101169
51MP0002115_abnormal_skeleton_extremities1.40000507
52MP0003137_abnormal_impulse_conducting1.39816655
53MP0004145_abnormal_muscle_electrophysio1.38907994
54MP0002332_abnormal_exercise_endurance1.38416587
55MP0008004_abnormal_stomach_pH1.38363485
56MP0002108_abnormal_muscle_morphology1.38190267
57MP0003329_amyloid_beta_deposits1.34340361
58MP0004085_abnormal_heartbeat1.34303227
59MP0002269_muscular_atrophy1.32355186
60MP0005508_abnormal_skeleton_morphology1.31747194
61MP0005409_darkened_coat_color1.30685521
62* MP0000343_altered_response_to1.29214126
63MP0004233_abnormal_muscle_weight1.29056976
64MP0003221_abnormal_cardiomyocyte_apopto1.28675703
65MP0003950_abnormal_plasma_membrane1.26340407
66MP0004130_abnormal_muscle_cell1.25458498
67MP0005595_abnormal_vascular_smooth1.23049373
68MP0003828_pulmonary_edema1.18358651
69MP0000569_abnormal_digit_pigmentation1.17334268
70MP0002796_impaired_skin_barrier1.15208451
71MP0002168_other_aberrant_phenotype1.14801564
72MP0000015_abnormal_ear_pigmentation1.13069567
73MP0004185_abnormal_adipocyte_glucose1.12898301
74MP0002089_abnormal_postnatal_growth/wei1.11697188
75MP0000372_irregular_coat_pigmentation1.11658301
76MP0005023_abnormal_wound_healing1.10898156
77MP0003941_abnormal_skin_development1.10894766
78MP0003385_abnormal_body_wall1.10383019
79MP0003868_abnormal_feces_composition1.10130898
80MP0000920_abnormal_myelination1.08520300
81MP0002113_abnormal_skeleton_development1.07168283
82MP0005360_urolithiasis1.06422970
83MP0002234_abnormal_pharynx_morphology1.05796771
84MP0000604_amyloidosis1.05425770
85MP0001533_abnormal_skeleton_physiology1.03387393
86MP0005390_skeleton_phenotype1.02005636
87MP0001915_intracranial_hemorrhage1.01763537
88MP0003303_peritoneal_inflammation1.01100631
89MP0010352_gastrointestinal_tract_polyps1.00281881
90MP0002060_abnormal_skin_morphology0.99523738
91MP0005367_renal/urinary_system_phenotyp0.98970625
92MP0000516_abnormal_urinary_system0.98970625
93MP0003453_abnormal_keratinocyte_physiol0.98801906
94MP0002139_abnormal_hepatobiliary_system0.98740912
95MP0005666_abnormal_adipose_tissue0.97277387
96* MP0005166_decreased_susceptibility_to0.94939445
97MP0001879_abnormal_lymphatic_vessel0.94936025
98MP0004510_myositis0.89585131
99MP0002090_abnormal_vision0.87480548
100MP0003191_abnormal_cellular_cholesterol0.87178409
101* MP0003448_altered_tumor_morphology0.86672639
102MP0002127_abnormal_cardiovascular_syste0.86239663
103MP0003091_abnormal_cell_migration0.85344582
104MP0003195_calcinosis0.84840667
105MP0005623_abnormal_meninges_morphology0.84669170
106MP0002254_reproductive_system_inflammat0.83461287
107MP0000371_diluted_coat_color0.83313388
108MP0001542_abnormal_bone_strength0.82601403
109MP0002295_abnormal_pulmonary_circulatio0.82268404
110MP0004043_abnormal_pH_regulation0.81756570
111MP0006082_CNS_inflammation0.81343766
112MP0010030_abnormal_orbit_morphology0.81181478
113MP0000733_abnormal_muscle_development0.80229102
114MP0003136_yellow_coat_color0.80024816
115MP0005174_abnormal_tail_pigmentation0.79792053
116MP0003634_abnormal_glial_cell0.79137912
117MP0003755_abnormal_palate_morphology0.78797842
118MP0008961_abnormal_basal_metabolism0.77553824
119MP0002109_abnormal_limb_morphology0.77037194
120MP0010234_abnormal_vibrissa_follicle0.76423642
121MP0005164_abnormal_response_to0.75996266
122MP0003795_abnormal_bone_structure0.72855802
123MP0001324_abnormal_eye_pigmentation0.70926784
124MP0001243_abnormal_dermal_layer0.70618407
125MP0004858_abnormal_nervous_system0.70478635
126MP0000767_abnormal_smooth_muscle0.70278884
127MP0001881_abnormal_mammary_gland0.69829962
128MP0000230_abnormal_systemic_arterial0.69819965
129MP0009053_abnormal_anal_canal0.69667143
130MP0009840_abnormal_foam_cell0.69353993
131MP0002128_abnormal_blood_circulation0.69100359
132MP0005167_abnormal_blood-brain_barrier0.68538608
133MP0003935_abnormal_craniofacial_develop0.68094729
134* MP0000266_abnormal_heart_morphology0.67994865
135MP0002998_abnormal_bone_remodeling0.67707877
136MP0001853_heart_inflammation0.67454558
137MP0002133_abnormal_respiratory_system0.67304906
138MP0005388_respiratory_system_phenotype0.67304906
139MP0001270_distended_abdomen0.66887595
140MP0002938_white_spotting0.66514457
141MP0001501_abnormal_sleep_pattern0.66461945
142MP0005085_abnormal_gallbladder_physiolo0.66204926
143MP0005187_abnormal_penis_morphology0.64395975
144MP0005165_increased_susceptibility_to0.62623036
145MP0003045_fibrosis0.62228603
146MP0003075_altered_response_to0.61352628

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)7.43510084
2Vitreoretinal degeneration (HP:0000655)6.53976205
3Irregular epiphyses (HP:0010582)6.53095619
4Hypoplastic ischia (HP:0003175)6.13209359
5Abnormality of the ischium (HP:0003174)5.47666452
6Cupped ribs (HP:0000887)5.11782870
7Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.88241479
8Abnormal tarsal ossification (HP:0008369)4.36049434
9Flat acetabular roof (HP:0003180)4.26516809
10Small epiphyses (HP:0010585)4.14892562
11Hyperphosphatemia (HP:0002905)3.79139800
12Protrusio acetabuli (HP:0003179)3.76946634
13Flat capital femoral epiphysis (HP:0003370)3.76668491
14Delayed epiphyseal ossification (HP:0002663)3.74921710
15Follicular hyperkeratosis (HP:0007502)3.73376677
16Muscle fiber splitting (HP:0003555)3.73095718
17Vascular tortuosity (HP:0004948)3.65618008
18Arterial tortuosity (HP:0005116)3.64059012
19Metaphyseal cupping (HP:0003021)3.63803371
20Aortic dissection (HP:0002647)3.52176455
21Arthropathy (HP:0003040)3.51553497
22Tetany (HP:0001281)3.43406141
23Genu varum (HP:0002970)3.40394598
24Neonatal short-limb short stature (HP:0008921)3.31159623
25Mitral stenosis (HP:0001718)3.29549222
26Neurofibrillary tangles (HP:0002185)3.25056704
27Increased connective tissue (HP:0009025)3.19682235
28Vacuolated lymphocytes (HP:0001922)3.19040817
29Systemic lupus erythematosus (HP:0002725)3.16917366
30Flattened epiphyses (HP:0003071)3.14144082
31Exercise-induced muscle cramps (HP:0003710)3.14060912
32Osteoarthritis (HP:0002758)3.11324277
33Soft skin (HP:0000977)3.11027743
34Abnormal foot bone ossification (HP:0010675)3.05301564
35Sudden death (HP:0001699)3.03314514
36Hypoplasia of the iris (HP:0007676)2.99746349
37Abnormality of glycolipid metabolism (HP:0010969)2.97565969
38Abnormality of liposaccharide metabolism (HP:0010968)2.97565969
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.97565969
40Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.97396748
41Abnormality of femoral epiphyses (HP:0006499)2.97396748
42Exercise-induced myalgia (HP:0003738)2.91378574
43Abnormality of the vertebral endplates (HP:0005106)2.91139000
44Type 1 muscle fiber predominance (HP:0003803)2.91043135
45Protuberant abdomen (HP:0001538)2.87002553
46Glomerulonephritis (HP:0000099)2.86904377
47Abnormal vertebral ossification (HP:0100569)2.85610362
48Distal lower limb muscle weakness (HP:0009053)2.84713022
49Abnormality of the calf musculature (HP:0001430)2.84645370
50Hyporeflexia of lower limbs (HP:0002600)2.84364491
51Waddling gait (HP:0002515)2.82155048
52Abnormality of the pubic bones (HP:0003172)2.80076649
53Vertebral compression fractures (HP:0002953)2.79980988
54Hip contracture (HP:0003273)2.79958525
55White forelock (HP:0002211)2.78356923
56Right ventricular cardiomyopathy (HP:0011663)2.76656908
57Blue sclerae (HP:0000592)2.74094480
58Ventricular tachycardia (HP:0004756)2.71489536
59Patchy hypopigmentation of hair (HP:0011365)2.70993714
60Hyperparathyroidism (HP:0000843)2.70044584
61Abnormality of dentin (HP:0010299)2.68637960
62Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.67493808
63Absent epiphyses (HP:0010577)2.67493808
64Mild short stature (HP:0003502)2.65900662
65Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.65327394
66Cardiovascular calcification (HP:0011915)2.62778698
67Bladder diverticulum (HP:0000015)2.61944226
68Cervical subluxation (HP:0003308)2.61927867
69Limited hip movement (HP:0008800)2.61316289
70Coxa vara (HP:0002812)2.60806926
71Metaphyseal irregularity (HP:0003025)2.53750181
72Cerebral aneurysm (HP:0004944)2.52910285
73Abnormality of the phalanges of the 2nd finger (HP:0009541)2.52696582
74Ankle contracture (HP:0006466)2.52658999
75Cerebral inclusion bodies (HP:0100314)2.52032382
76Short femoral neck (HP:0100864)2.51369086
77Ovoid vertebral bodies (HP:0003300)2.51064501
78Abnormality of the epiphysis of the femoral head (HP:0010574)2.47779099
79Wormian bones (HP:0002645)2.45363843
80Spondylolisthesis (HP:0003302)2.44236907
81Amelogenesis imperfecta (HP:0000705)2.43174770
82Irregular vertebral endplates (HP:0003301)2.42557632
83Calf muscle hypertrophy (HP:0008981)2.42341752
84Abnormal gallbladder physiology (HP:0012438)2.38427443
85Cholecystitis (HP:0001082)2.38427443
86Hyperextensible skin (HP:0000974)2.37867830
87Ulnar deviation of the wrist (HP:0003049)2.37498967
88Osteolytic defects of the hand bones (HP:0009699)2.37410042
89Osteolytic defects of the phalanges of the hand (HP:0009771)2.37410042
90Abnormality of carpal bone ossification (HP:0006257)2.36915966
91Platyspondyly (HP:0000926)2.34898356
92Abnormality of calcium-phosphate metabolism (HP:0100530)2.33053869
93Tetraparesis (HP:0002273)2.32815613
94Complement deficiency (HP:0004431)2.31489881
95EMG: myopathic abnormalities (HP:0003458)2.31268572
96Deep venous thrombosis (HP:0002625)2.29312855
97Genu recurvatum (HP:0002816)2.28788741
98Thin ribs (HP:0000883)2.26752507
99Dysostosis multiplex (HP:0000943)2.26246388
100Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.25521692
101Vertebral hypoplasia (HP:0008417)2.25521692
102Muscle hypertrophy of the lower extremities (HP:0008968)2.25385900
103Muscle fiber inclusion bodies (HP:0100299)2.24835727
104Vascular calcification (HP:0004934)2.23850633
105Atrial fibrillation (HP:0005110)2.22516877
106Broad metatarsal (HP:0001783)2.22363182
107Aortic aneurysm (HP:0004942)2.21562737
108Spinal rigidity (HP:0003306)2.20668125
109Exostoses (HP:0100777)2.20240401
110Renal duplication (HP:0000075)2.20210749
111Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.19062412
112Peritonitis (HP:0002586)2.18622936
113Abnormality of the femoral head (HP:0003368)2.17966593
114Difficulty climbing stairs (HP:0003551)2.17279736
115Patent foramen ovale (HP:0001655)2.16360796
116Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.16134270
117Axonal loss (HP:0003447)2.13494821
118Beaking of vertebral bodies (HP:0004568)2.09800639
119Metaphyseal dysplasia (HP:0100255)2.09361988
120Alacrima (HP:0000522)2.08343747
121Shallow orbits (HP:0000586)2.07386073
122Primary atrial arrhythmia (HP:0001692)2.05532096
123Abnormality of complement system (HP:0005339)2.04758437
124Limb-girdle muscle atrophy (HP:0003797)2.04629652
125Nephritis (HP:0000123)2.04298303
126Pulmonary artery stenosis (HP:0004415)2.03573144
127Lumbar hyperlordosis (HP:0002938)2.02850929
128Thin bony cortex (HP:0002753)2.01142684
129Scapular winging (HP:0003691)2.00245229
130Stillbirth (HP:0003826)2.00167913
131Abnormality of the proximal phalanges of the hand (HP:0009834)2.00060957
132Abnormal cartilage morphology (HP:0002763)1.99950872
133Premature rupture of membranes (HP:0001788)1.99055758
134Asymmetric septal hypertrophy (HP:0001670)1.98454816
135Vertebral clefting (HP:0008428)1.98005809
136Fragile skin (HP:0001030)1.97384989
137Thoracolumbar scoliosis (HP:0002944)1.96222887
138Abnormality of the vitreous humor (HP:0004327)1.95928824
139Venous insufficiency (HP:0005293)1.95875076
140Mucopolysacchariduria (HP:0008155)1.93014461
141Urinary glycosaminoglycan excretion (HP:0003541)1.93014461
142Decreased lacrimation (HP:0000633)1.92663619
143Conjugated hyperbilirubinemia (HP:0002908)1.92407749
144Supraventricular arrhythmia (HP:0005115)1.91406056
145Supraventricular tachycardia (HP:0004755)1.91069238
146Dilatation of the ascending aorta (HP:0005111)1.90763569
147Mildly elevated creatine phosphokinase (HP:0008180)1.90368922
148Abnormality of the costochondral junction (HP:0000919)1.89600600
149Myoglobinuria (HP:0002913)1.89569738
150Myocardial infarction (HP:0001658)1.88854289
151Abnormality of polysaccharide metabolism (HP:0011012)1.88196340
152Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88196340
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88196340
154Venous abnormality (HP:0002624)1.87197144
155Enlarged epiphyses (HP:0010580)1.86952515
156Myotonia (HP:0002486)1.86951419
157Abnormal hand bone ossification (HP:0010660)1.86611070
158Lipoatrophy (HP:0100578)1.85619492
159Long toe (HP:0010511)1.85597830
160Difficulty running (HP:0009046)1.83641395
161Overgrowth (HP:0001548)1.83495604
162Ulnar claw (HP:0001178)1.83020554
163Hypoplasia of the odontoid process (HP:0003311)1.82656549
164Abnormality of monocarboxylic acid metabolism (HP:0010996)1.82631151
165Nemaline bodies (HP:0003798)1.82296188
166Congenital glaucoma (HP:0001087)1.82012828
167Severe Myopia (HP:0011003)1.81465756
168Short nail (HP:0001799)1.79415230
169Abnormal ossification of hand bones (HP:0005921)1.79286249
170Abnormality of incisor morphology (HP:0011063)1.79138032
171Ocular albinism (HP:0001107)1.78839624
172Action tremor (HP:0002345)1.78649354
173Aplasia/hypoplasia of the femur (HP:0005613)1.78483382
174Blue irides (HP:0000635)1.78408255
175Atrophic scars (HP:0001075)1.78261410
176Joint stiffness (HP:0001387)1.77952584
177Distal upper limb amyotrophy (HP:0007149)1.77404184
178Upper limb amyotrophy (HP:0009129)1.77404184
179J-shaped sella turcica (HP:0002680)1.73591463
180Elbow flexion contracture (HP:0002987)1.71626936
181Tibial bowing (HP:0002982)1.70501720
182Increased variability in muscle fiber diameter (HP:0003557)1.69467602
183Hypoventilation (HP:0002791)1.68793112
184Aortic regurgitation (HP:0001659)1.67761278
185Mitral valve prolapse (HP:0001634)1.65189795
186Slender build (HP:0001533)1.65164778
187Supranuclear gaze palsy (HP:0000605)1.64982588
188Nuclear cataract (HP:0100018)1.63602782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.78028145
2TRIM284.85875510
3OBSCN4.06603162
4STK38L3.55436437
5DDR23.48305810
6STK243.45879016
7NME13.09762806
8TTN2.90228107
9TRIB32.46010823
10PHKG12.23617939
11PHKG22.23617939
12LATS12.05079873
13LATS21.94091531
14TGFBR21.89443653
15PDK21.87151934
16PRKD31.79460172
17IRAK31.77888436
18EPHB21.76913719
19TIE11.75487167
20TAOK11.71815776
21DMPK1.68959803
22PRKG21.61670478
23MAP3K121.60670681
24RIPK11.58700477
25MAPK121.57113680
26WNK41.45370656
27ARAF1.41783585
28PKN21.37768351
29PDK31.32272724
30PDK41.32272724
31MYLK1.29704367
32* MAP3K31.28950908
33ABL21.27427961
34MAP3K111.19846313
35ROCK11.19390331
36EPHA31.15698770
37FER1.14738479
38PIK3CA1.13974093
39LMTK21.13637155
40PAK41.13361366
41EPHB11.13095327
42ERBB31.13057459
43PINK11.09392145
44ERN11.07826888
45MAP2K31.04408669
46MAP2K41.00478121
47TRPM70.98997454
48PTK2B0.98826618
49PAK30.97912928
50EPHA20.95289473
51LIMK10.95137082
52MAPKAPK30.93244919
53NEK60.92985614
54CASK0.92709897
55MAP3K90.91382249
56TAOK20.91141705
57PDGFRB0.90223696
58MAP3K50.90039507
59STK30.87810227
60MINK10.83401067
61MAP3K130.81328594
62MST1R0.79917682
63PIM20.79166436
64ROCK20.79069698
65NEK10.79003661
66EIF2AK30.78160037
67PLK20.75344937
68KSR10.75002873
69PTK20.74836007
70CDC42BPA0.74066157
71PDGFRA0.71464803
72MAPK70.70220322
73MET0.69232726
74MST40.68278982
75ILK0.67226255
76BCKDK0.66761527
77GRK70.66053957
78CDK180.65867638
79PIK3CG0.65165628
80PRKD10.64261699
81MAP2K10.64216343
82MAP3K40.60086873
83PTK60.59155547
84MOS0.59086032
85ERBB40.58702080
86EPHA40.58554642
87RET0.57274877
88JAK10.57241897
89PAK60.55337873
90BCR0.54822830
91MAP3K20.54612208
92MAP3K140.54029611
93WNK30.52323149
94STK380.50154594
95KIT0.49581988
96MAP3K70.49380488
97CAMK2G0.47847612
98TBK10.47775196
99SIK10.47624255
100MUSK0.46595782
101STK390.46238370
102PRKAA10.46021378
103CAMK40.45637225
104* GSK3A0.45570973
105TGFBR10.45220301
106CAMK2A0.44715277
107MAP3K10.44200032
108PAK20.43933224
109NEK90.43831421
110PRKCE0.43277513
111ADRBK10.43226371
112MARK10.42823331
113KSR20.42229687
114LRRK20.42052115
115DAPK30.41896298
116FGFR10.41741586
117GRK50.40885971
118CAMK2B0.40292276
119MAPKAPK20.40288692
120MAP3K60.40112553
121TYRO30.39510570
122PRKCG0.39469825
123PRKACG0.39172121
124TESK10.38365563
125PKN10.38327094
126FGFR40.38146260
127CAMK2D0.36678312
128NTRK10.36057321
129KDR0.34539440
130CDK150.34264020
131FGFR20.34148105
132NTRK30.32665998
133INSR0.32095554
134PDPK10.28265312
135CDK140.27055323
136PRKD20.26845904

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.25535745
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.69002656
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.65590575
4Dilated cardiomyopathy_Homo sapiens_hsa054142.63720058
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.48514341
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.45531977
7Protein digestion and absorption_Homo sapiens_hsa049742.32943505
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26945032
9Mineral absorption_Homo sapiens_hsa049782.26825786
10Cardiac muscle contraction_Homo sapiens_hsa042602.25356566
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.11294655
12Prion diseases_Homo sapiens_hsa050201.90022471
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.83551298
14Focal adhesion_Homo sapiens_hsa045101.80889697
15Starch and sucrose metabolism_Homo sapiens_hsa005001.71981707
16Lysosome_Homo sapiens_hsa041421.65410563
17Other glycan degradation_Homo sapiens_hsa005111.64589490
18Propanoate metabolism_Homo sapiens_hsa006401.40884275
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37491154
20Arginine biosynthesis_Homo sapiens_hsa002201.33313176
21Pertussis_Homo sapiens_hsa051331.33249539
22Fatty acid degradation_Homo sapiens_hsa000711.33083213
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28181462
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26627171
25Nitrogen metabolism_Homo sapiens_hsa009101.23824674
26TNF signaling pathway_Homo sapiens_hsa046681.22234495
27Vibrio cholerae infection_Homo sapiens_hsa051101.21951537
28Carbon metabolism_Homo sapiens_hsa012001.21299431
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19762152
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15757654
31Caffeine metabolism_Homo sapiens_hsa002321.13073421
32Proteoglycans in cancer_Homo sapiens_hsa052051.12944584
33TGF-beta signaling pathway_Homo sapiens_hsa043501.12845047
34PPAR signaling pathway_Homo sapiens_hsa033201.09315586
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08719653
36Bile secretion_Homo sapiens_hsa049761.08461892
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07254987
38Butanoate metabolism_Homo sapiens_hsa006501.07083231
39Fatty acid metabolism_Homo sapiens_hsa012121.05411593
40Hippo signaling pathway_Homo sapiens_hsa043901.04755938
41Amoebiasis_Homo sapiens_hsa051461.03703507
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03194897
43African trypanosomiasis_Homo sapiens_hsa051431.01773346
44Malaria_Homo sapiens_hsa051441.01357615
45Insulin resistance_Homo sapiens_hsa049311.01183207
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98064857
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96364643
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94451603
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93655041
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93213703
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92482658
52Rheumatoid arthritis_Homo sapiens_hsa053230.91845734
53Sulfur metabolism_Homo sapiens_hsa009200.90601368
54Adherens junction_Homo sapiens_hsa045200.89298621
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.87862613
56Pyruvate metabolism_Homo sapiens_hsa006200.87662910
57Arginine and proline metabolism_Homo sapiens_hsa003300.87474543
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86964980
59Oxidative phosphorylation_Homo sapiens_hsa001900.85006983
60Tight junction_Homo sapiens_hsa045300.84898721
61Salmonella infection_Homo sapiens_hsa051320.83685968
62Parkinsons disease_Homo sapiens_hsa050120.83528297
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81948188
64HIF-1 signaling pathway_Homo sapiens_hsa040660.81685894
65Galactose metabolism_Homo sapiens_hsa000520.80922755
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80411907
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78767625
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77822239
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.77728331
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76739270
71Complement and coagulation cascades_Homo sapiens_hsa046100.75533783
72Chemical carcinogenesis_Homo sapiens_hsa052040.75504912
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74921861
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74086543
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72285493
76Viral myocarditis_Homo sapiens_hsa054160.71417702
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71002617
78Basal cell carcinoma_Homo sapiens_hsa052170.70881178
79Fatty acid elongation_Homo sapiens_hsa000620.69960462
80Glucagon signaling pathway_Homo sapiens_hsa049220.69054084
81Staphylococcus aureus infection_Homo sapiens_hsa051500.68939973
82Hedgehog signaling pathway_Homo sapiens_hsa043400.68522042
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67721883
84Gap junction_Homo sapiens_hsa045400.67261205
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65979656
86* Oxytocin signaling pathway_Homo sapiens_hsa049210.65938973
87Renin secretion_Homo sapiens_hsa049240.64813266
88Tryptophan metabolism_Homo sapiens_hsa003800.63870818
89Thyroid hormone synthesis_Homo sapiens_hsa049180.63836996
90Small cell lung cancer_Homo sapiens_hsa052220.63108682
91Biosynthesis of amino acids_Homo sapiens_hsa012300.61768958
92Pancreatic secretion_Homo sapiens_hsa049720.61493075
93Gastric acid secretion_Homo sapiens_hsa049710.60865551
94Cocaine addiction_Homo sapiens_hsa050300.60459645
95Bladder cancer_Homo sapiens_hsa052190.60227674
96Insulin signaling pathway_Homo sapiens_hsa049100.59836025
97Phenylalanine metabolism_Homo sapiens_hsa003600.58185696
98GnRH signaling pathway_Homo sapiens_hsa049120.57572710
99Olfactory transduction_Homo sapiens_hsa047400.57348355
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.57109055
101Melanoma_Homo sapiens_hsa052180.56769369
102beta-Alanine metabolism_Homo sapiens_hsa004100.56582448
103Toxoplasmosis_Homo sapiens_hsa051450.56266624
104Fatty acid biosynthesis_Homo sapiens_hsa000610.55788291
105Dorso-ventral axis formation_Homo sapiens_hsa043200.55571556
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54968221
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54937316
108Renal cell carcinoma_Homo sapiens_hsa052110.54580725
109Glutathione metabolism_Homo sapiens_hsa004800.54398035
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.54263163
111Alzheimers disease_Homo sapiens_hsa050100.54232521
112AMPK signaling pathway_Homo sapiens_hsa041520.53773609
113Circadian rhythm_Homo sapiens_hsa047100.53229791
114Melanogenesis_Homo sapiens_hsa049160.52263191
115Tyrosine metabolism_Homo sapiens_hsa003500.51282644
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49559158
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48869048
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48723593
119Steroid biosynthesis_Homo sapiens_hsa001000.48675799
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48258319
121Ovarian steroidogenesis_Homo sapiens_hsa049130.47957302
122Glioma_Homo sapiens_hsa052140.47107114
123MicroRNAs in cancer_Homo sapiens_hsa052060.47104134
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47077864
125Sphingolipid metabolism_Homo sapiens_hsa006000.46957005
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46514283
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46349843
128Calcium signaling pathway_Homo sapiens_hsa040200.45875999
129VEGF signaling pathway_Homo sapiens_hsa043700.45484437
130Histidine metabolism_Homo sapiens_hsa003400.45418721
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.45267914
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44980489
133Shigellosis_Homo sapiens_hsa051310.44974660
134Estrogen signaling pathway_Homo sapiens_hsa049150.44838127
135mTOR signaling pathway_Homo sapiens_hsa041500.43598597
136Rap1 signaling pathway_Homo sapiens_hsa040150.42965406
137Axon guidance_Homo sapiens_hsa043600.42244609
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42149452
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.41863579
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41543804
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.41181380
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41142551
143Glutamatergic synapse_Homo sapiens_hsa047240.40362509
144Phagosome_Homo sapiens_hsa041450.40163265
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39497270
146Fructose and mannose metabolism_Homo sapiens_hsa000510.37802112
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37610732
148Salivary secretion_Homo sapiens_hsa049700.37557067

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