RCBTB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.95885255
2central nervous system myelination (GO:0022010)8.95885255
3L-phenylalanine catabolic process (GO:0006559)7.24930805
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.24930805
5fatty acid elongation (GO:0030497)6.97581068
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.47735544
7L-phenylalanine metabolic process (GO:0006558)6.47735544
8paraxial mesoderm development (GO:0048339)5.71014404
9aromatic amino acid family catabolic process (GO:0009074)5.22473547
10cholesterol biosynthetic process (GO:0006695)5.05447562
11ensheathment of neurons (GO:0007272)4.83823400
12axon ensheathment (GO:0008366)4.83823400
13myelination (GO:0042552)4.83162725
14pre-miRNA processing (GO:0031054)4.66244395
15long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.56068822
16sterol biosynthetic process (GO:0016126)4.39421203
17myelin maintenance (GO:0043217)4.38715428
18fatty-acyl-CoA biosynthetic process (GO:0046949)4.28166676
19coenzyme catabolic process (GO:0009109)4.21871934
20response to methylmercury (GO:0051597)4.12393090
21single strand break repair (GO:0000012)4.05388459
22very long-chain fatty acid metabolic process (GO:0000038)4.02538837
23bile acid biosynthetic process (GO:0006699)3.99589703
24nuclear pore complex assembly (GO:0051292)3.97513972
25long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.94938752
26glycerophospholipid catabolic process (GO:0046475)3.87937544
27apical protein localization (GO:0045176)3.85221668
28negative regulation of neurotransmitter secretion (GO:0046929)3.84440592
29DNA ligation (GO:0006266)3.84206729
30tyrosine metabolic process (GO:0006570)3.82117215
31alpha-linolenic acid metabolic process (GO:0036109)3.80048361
32fatty-acyl-CoA metabolic process (GO:0035337)3.76955855
33asymmetric protein localization (GO:0008105)3.67617661
34nuclear pore organization (GO:0006999)3.65251762
35regulation of lipoprotein metabolic process (GO:0050746)3.65191808
36bile acid metabolic process (GO:0008206)3.63773421
37glyoxylate metabolic process (GO:0046487)3.61213140
38heme transport (GO:0015886)3.55218060
39long-chain fatty acid biosynthetic process (GO:0042759)3.52316785
40aromatic amino acid family metabolic process (GO:0009072)3.51914963
41amyloid precursor protein metabolic process (GO:0042982)3.46706927
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.46033457
43acyl-CoA biosynthetic process (GO:0071616)3.44819503
44thioester biosynthetic process (GO:0035384)3.44819503
45cofactor catabolic process (GO:0051187)3.42499297
46establishment of mitochondrion localization (GO:0051654)3.41385780
47presynaptic membrane organization (GO:0097090)3.39217693
48negative regulation of neurotransmitter transport (GO:0051589)3.38668444
49indole-containing compound catabolic process (GO:0042436)3.37120593
50indolalkylamine catabolic process (GO:0046218)3.37120593
51tryptophan catabolic process (GO:0006569)3.37120593
52lactate metabolic process (GO:0006089)3.36672259
53presynaptic membrane assembly (GO:0097105)3.30366440
54mitotic sister chromatid cohesion (GO:0007064)3.29593778
55intestinal cholesterol absorption (GO:0030299)3.28003375
56isoprenoid biosynthetic process (GO:0008299)3.25251694
57tryptophan metabolic process (GO:0006568)3.23227473
58cholesterol efflux (GO:0033344)3.22960689
59cholesterol metabolic process (GO:0008203)3.22482910
60regulation of Golgi to plasma membrane protein transport (GO:0042996)3.22303359
61negative regulation of fibrinolysis (GO:0051918)3.21703455
62positive regulation of oligodendrocyte differentiation (GO:0048714)3.21326682
63spermatid nucleus differentiation (GO:0007289)3.19912897
64kynurenine metabolic process (GO:0070189)3.19261815
65response to lipoprotein particle (GO:0055094)3.19127725
66high-density lipoprotein particle remodeling (GO:0034375)3.17940988
67hyperosmotic salinity response (GO:0042538)3.16375843
68regulation of fibrinolysis (GO:0051917)3.15818762
69oligodendrocyte differentiation (GO:0048709)3.14959754
70cysteine metabolic process (GO:0006534)3.14298557
71creatine metabolic process (GO:0006600)3.11820683
72DNA unwinding involved in DNA replication (GO:0006268)3.10162977
73cell fate commitment involved in formation of primary germ layer (GO:0060795)3.08729143
74very-low-density lipoprotein particle assembly (GO:0034379)3.07616751
75peptidyl-glutamic acid carboxylation (GO:0017187)3.07498253
76protein carboxylation (GO:0018214)3.07498253
77eye photoreceptor cell differentiation (GO:0001754)3.06925939
78photoreceptor cell differentiation (GO:0046530)3.06925939
79regulation of RNA export from nucleus (GO:0046831)3.06044909
80L-serine metabolic process (GO:0006563)3.05192948
81plasma lipoprotein particle clearance (GO:0034381)3.02935050
82positive regulation of dendritic spine morphogenesis (GO:0061003)3.02749030
83negative regulation of DNA recombination (GO:0045910)3.01618546
84sterol metabolic process (GO:0016125)3.01435444
85aldehyde catabolic process (GO:0046185)3.00963486
86regulation of meiosis I (GO:0060631)3.00836093
87DNA topological change (GO:0006265)3.00116996
88establishment of integrated proviral latency (GO:0075713)2.99702441
89glutamate metabolic process (GO:0006536)2.98654015
90alpha-amino acid catabolic process (GO:1901606)2.97135275
91steroid biosynthetic process (GO:0006694)2.97040726
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92885544
93somatic hypermutation of immunoglobulin genes (GO:0016446)2.92885544
94regulation of bile acid biosynthetic process (GO:0070857)2.91947187
95acyl-CoA metabolic process (GO:0006637)2.91511116
96thioester metabolic process (GO:0035383)2.91511116
97response to lead ion (GO:0010288)2.91445494
98dicarboxylic acid catabolic process (GO:0043649)2.90052007
99regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.89341380
100serine family amino acid biosynthetic process (GO:0009070)2.88461506
101urea metabolic process (GO:0019627)2.87981932
102urea cycle (GO:0000050)2.87981932
103acetyl-CoA metabolic process (GO:0006084)2.86455516
104left/right axis specification (GO:0070986)2.82206092
105triglyceride homeostasis (GO:0070328)2.82052908
106acylglycerol homeostasis (GO:0055090)2.82052908
107peptidyl-tyrosine autophosphorylation (GO:0038083)2.80207495
108regulation of cholesterol biosynthetic process (GO:0045540)2.79357830
109regulation of cholesterol esterification (GO:0010872)2.77815887
110negative regulation of lipase activity (GO:0060192)2.76117498
111cellular amino acid catabolic process (GO:0009063)2.75639975
112positive regulation of cellular amine metabolic process (GO:0033240)2.75521595
113iron coordination entity transport (GO:1901678)2.74390204
114ethanol oxidation (GO:0006069)2.74385382
115regulation of collateral sprouting (GO:0048670)2.73910038
116pore complex assembly (GO:0046931)2.73535894
117aspartate family amino acid catabolic process (GO:0009068)2.73440791
118notochord development (GO:0030903)2.73082139
119amyloid precursor protein catabolic process (GO:0042987)2.73080426
120primitive streak formation (GO:0090009)2.72470807
121cilium or flagellum-dependent cell motility (GO:0001539)2.72299566
122import into cell (GO:0098657)2.72290326
123regulation of development, heterochronic (GO:0040034)2.71646993
124regulation of triglyceride catabolic process (GO:0010896)2.69876543
125positive regulation of histone H3-K4 methylation (GO:0051571)2.69448927
126ventricular trabecula myocardium morphogenesis (GO:0003222)2.69365595
127short-chain fatty acid metabolic process (GO:0046459)2.69242032
128regulation of protein activation cascade (GO:2000257)2.68526133
129complement activation, alternative pathway (GO:0006957)2.67750562
130nucleotide transmembrane transport (GO:1901679)2.66185484
131sulfur amino acid catabolic process (GO:0000098)2.65978156
132reverse cholesterol transport (GO:0043691)2.65663454
133regulation of chromatin silencing (GO:0031935)2.64036013
134negative regulation of hormone biosynthetic process (GO:0032353)2.57993969
135positive regulation of SMAD protein import into nucleus (GO:0060391)2.57846596
136protein targeting to lysosome (GO:0006622)2.57819072
137establishment of protein localization to vacuole (GO:0072666)2.57819072
138protein targeting to vacuole (GO:0006623)2.57819072
139axonemal dynein complex assembly (GO:0070286)2.57085092
140negative regulation of fibroblast apoptotic process (GO:2000270)2.54958487
141protein prenylation (GO:0018342)2.54414137
142prenylation (GO:0097354)2.54414137
143embryonic retina morphogenesis in camera-type eye (GO:0060059)2.54299991
144mitochondrial fission (GO:0000266)2.50511583
145negative regulation of meiosis (GO:0045835)2.50347268
146negative regulation of dendrite morphogenesis (GO:0050774)2.49298566
147histone H2B ubiquitination (GO:0033523)2.49023729
148spindle assembly involved in mitosis (GO:0090307)2.45205449
149protein ADP-ribosylation (GO:0006471)2.44056948
150suckling behavior (GO:0001967)2.44017657
151cytoplasmic mRNA processing body assembly (GO:0033962)2.42684198
152regulation of nucleobase-containing compound transport (GO:0032239)2.41837848
153nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.41531117
154regulation of sister chromatid cohesion (GO:0007063)2.39107987
155peptidyl-cysteine modification (GO:0018198)2.38725027
156regulation of Rac protein signal transduction (GO:0035020)2.38694864
157non-recombinational repair (GO:0000726)2.37862689
158double-strand break repair via nonhomologous end joining (GO:0006303)2.37862689
159regulation of transforming growth factor beta2 production (GO:0032909)2.37717202
160cerebellar granule cell differentiation (GO:0021707)2.34623703
161hippo signaling (GO:0035329)2.34451662
162somite rostral/caudal axis specification (GO:0032525)2.33361239
163neuronal stem cell maintenance (GO:0097150)2.32086343
164regulation of histone H3-K9 methylation (GO:0051570)2.30942947
165establishment of nucleus localization (GO:0040023)2.29678710
166nodal signaling pathway (GO:0038092)2.27066867
167forebrain neuron differentiation (GO:0021879)2.26983464
168regulation of oxidative stress-induced neuron death (GO:1903203)2.26565219
169inositol metabolic process (GO:0006020)2.26190699
170protoporphyrinogen IX biosynthetic process (GO:0006782)2.25446738
171regulation of protein glycosylation (GO:0060049)2.25236922
172lung-associated mesenchyme development (GO:0060484)2.24373698
173negative regulation of hormone metabolic process (GO:0032351)2.24361553
174neuron cell-cell adhesion (GO:0007158)2.23631491
175regulation of growth hormone secretion (GO:0060123)2.23573970
176definitive hemopoiesis (GO:0060216)2.23370035
177cilium movement (GO:0003341)2.22414382
178negative regulation of JUN kinase activity (GO:0043508)2.22190915
179regulation of posttranscriptional gene silencing (GO:0060147)2.22009340
180regulation of gene silencing by miRNA (GO:0060964)2.22009340
181regulation of gene silencing by RNA (GO:0060966)2.22009340
182regulation of timing of cell differentiation (GO:0048505)2.21427170
183pyrimidine dimer repair (GO:0006290)2.20501245
184histone H2A acetylation (GO:0043968)2.19907821
185monoubiquitinated protein deubiquitination (GO:0035520)2.19217070
186ribosome assembly (GO:0042255)2.17300581
187Golgi to endosome transport (GO:0006895)2.17091042
188microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.13870159
189regulation of cell fate commitment (GO:0010453)2.12959595
190lysine catabolic process (GO:0006554)2.11960496
191lysine metabolic process (GO:0006553)2.11960496
192ectodermal placode formation (GO:0060788)2.11948702
193detection of calcium ion (GO:0005513)2.11870339
194regulation of centriole replication (GO:0046599)2.11726541
195regulation of DNA damage checkpoint (GO:2000001)2.11443665
196RNA polyadenylation (GO:0043631)2.11421216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.07075942
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.81032485
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.44900122
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.35487930
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.30757309
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.84197893
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.80855313
8GBX2_23144817_ChIP-Seq_PC3_Human2.58917043
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51616937
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.44489768
11SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.39124597
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38411811
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38303473
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.37886502
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36238073
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.23895400
17TAF15_26573619_Chip-Seq_HEK293_Human2.16880914
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.09373247
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04297069
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.03851905
21OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.00373926
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.96621680
23E2F7_22180533_ChIP-Seq_HELA_Human1.96529053
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94534507
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.94305304
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.90226024
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90176840
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.80816107
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79499257
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72535190
31TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.69607244
32* FOXA2_19822575_ChIP-Seq_HepG2_Human1.69584482
33NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.61511873
34STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.57594724
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57273130
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51962299
37HTT_18923047_ChIP-ChIP_STHdh_Human1.48478834
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47836390
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.46964541
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45349529
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44403470
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.44039658
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41963714
44STAT3_23295773_ChIP-Seq_U87_Human1.38474454
45* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38304957
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.37171039
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.34636117
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33389656
49ER_23166858_ChIP-Seq_MCF-7_Human1.32638657
50* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.32550004
51TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32008079
52* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28692611
53TBX3_20139965_ChIP-Seq_MESCs_Mouse1.27994087
54* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.26696900
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.26093411
56TBX3_20139965_ChIP-Seq_ESCs_Mouse1.25828434
57YAP1_20516196_ChIP-Seq_MESCs_Mouse1.25661158
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25641902
59P300_19829295_ChIP-Seq_ESCs_Human1.25509653
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24994960
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24994960
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22198544
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.22082446
64SMAD4_21799915_ChIP-Seq_A2780_Human1.21172593
65* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20831483
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.20305278
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20098852
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19378411
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17250926
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17133533
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17081329
72E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17053744
73NANOG_16518401_ChIP-PET_MESCs_Mouse1.16634410
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16527908
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.16271534
76AR_21909140_ChIP-Seq_LNCAP_Human1.16131006
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14309576
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13998618
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.13297572
80ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11009272
81FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10532662
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09846078
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09751873
84FUS_26573619_Chip-Seq_HEK293_Human1.09585461
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09395959
86NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08596619
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08491765
88TCF4_23295773_ChIP-Seq_U87_Human1.08359419
89FOXA1_25552417_ChIP-Seq_VCAP_Human1.08313766
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07993645
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07956969
92IRF1_19129219_ChIP-ChIP_H3396_Human1.07485892
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06802540
94DROSHA_22980978_ChIP-Seq_HELA_Human1.06162181
95ISL1_27105846_Chip-Seq_CPCs_Mouse1.06037715
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05995503
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05076036
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.04762170
99SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04493761
100IGF1R_20145208_ChIP-Seq_DFB_Human1.04450598
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04380864
102STAT3_18555785_ChIP-Seq_MESCs_Mouse1.04152037
103CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03590937
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03372594
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03152215
106MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03130687
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03020668
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.02812998
109SOX9_26525672_Chip-Seq_HEART_Mouse1.02804856
110RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02583550
111EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02583550
112CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01430063
113* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01319300
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01124106
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.00642562
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00247783
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99942431
118* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99865190
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99292051
120* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99159265
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99125389
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98929354
123SMAD4_21741376_ChIP-Seq_EPCs_Human0.98868308
124* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98692637
125EZH2_27294783_Chip-Seq_ESCs_Mouse0.98579814
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98376474
127PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98311611
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98184716
129P300_18555785_Chip-Seq_ESCs_Mouse0.97693311
130JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96626741
131* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96506303
132DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96021308
133TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.95463659
134CBX2_27304074_Chip-Seq_ESCs_Mouse0.94653506
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94188216
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.94109054
137BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93817148
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93136099
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92799180
140EZH2_27294783_Chip-Seq_NPCs_Mouse0.92792620
141EWS_26573619_Chip-Seq_HEK293_Human0.92572349
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.92470262
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92395455
144NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91241993
145AR_21572438_ChIP-Seq_LNCaP_Human0.91152342
146POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91011002
147KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90828780
148KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90828780
149KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90828780
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.90097421
151TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89785659
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89684094
153EZH2_27304074_Chip-Seq_ESCs_Mouse0.89540323
154P53_22387025_ChIP-Seq_ESCs_Mouse0.89058999
155SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.88215808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.61420219
2MP0005360_urolithiasis4.67533378
3MP0003806_abnormal_nucleotide_metabolis4.21191004
4MP0005085_abnormal_gallbladder_physiolo4.11231758
5MP0005365_abnormal_bile_salt4.05235425
6MP0000920_abnormal_myelination3.79004896
7MP0003787_abnormal_imprinting3.21427044
8MP0008875_abnormal_xenobiotic_pharmacok2.97019760
9MP0003195_calcinosis2.89365677
10MP0003252_abnormal_bile_duct2.83195920
11MP0010352_gastrointestinal_tract_polyps2.58906343
12MP0001984_abnormal_olfaction2.57903030
13MP0003690_abnormal_glial_cell2.28653556
14MP0010368_abnormal_lymphatic_system2.19719996
15MP0003868_abnormal_feces_composition2.16456001
16MP0008057_abnormal_DNA_replication2.16396214
17MP0003950_abnormal_plasma_membrane2.13512968
18MP0001188_hyperpigmentation2.11900738
19MP0003567_abnormal_fetal_cardiomyocyte2.10128815
20MP0004043_abnormal_pH_regulation2.09319491
21MP0004270_analgesia2.09001139
22MP0000516_abnormal_urinary_system2.08290608
23MP0005367_renal/urinary_system_phenotyp2.08290608
24MP0001666_abnormal_nutrient_absorption2.08187869
25MP0005083_abnormal_biliary_tract2.07287657
26MP0009840_abnormal_foam_cell1.99691401
27MP0003300_gastrointestinal_ulcer1.96463837
28MP0008877_abnormal_DNA_methylation1.94100226
29MP0000566_synostosis1.93240602
30MP0003941_abnormal_skin_development1.85235941
31MP0000462_abnormal_digestive_system1.83964667
32MP0004885_abnormal_endolymph1.82583524
33MP0001485_abnormal_pinna_reflex1.71546940
34MP0002084_abnormal_developmental_patter1.67887638
35MP0004957_abnormal_blastocyst_morpholog1.65970151
36MP0008058_abnormal_DNA_repair1.63181171
37MP0010329_abnormal_lipoprotein_level1.62067967
38MP0004859_abnormal_synaptic_plasticity1.59975333
39MP0010678_abnormal_skin_adnexa1.59465953
40MP0005332_abnormal_amino_acid1.57775982
41MP0001529_abnormal_vocalization1.57243327
42MP0004742_abnormal_vestibular_system1.50576866
43MP0009697_abnormal_copulation1.50045660
44MP0003634_abnormal_glial_cell1.49334954
45MP0002118_abnormal_lipid_homeostasis1.48698395
46MP0002751_abnormal_autonomic_nervous1.47622750
47MP0000778_abnormal_nervous_system1.46163779
48MP0002909_abnormal_adrenal_gland1.45632930
49MP0003880_abnormal_central_pattern1.45161277
50MP0003111_abnormal_nucleus_morphology1.44390014
51MP0005408_hypopigmentation1.42954453
52MP0001486_abnormal_startle_reflex1.42134525
53MP0003890_abnormal_embryonic-extraembry1.41829416
54MP0005423_abnormal_somatic_nervous1.40698102
55MP0001346_abnormal_lacrimal_gland1.40374680
56MP0003632_abnormal_nervous_system1.37993863
57MP0006054_spinal_hemorrhage1.37728584
58MP0002877_abnormal_melanocyte_morpholog1.36837278
59MP0005409_darkened_coat_color1.36088883
60MP0001915_intracranial_hemorrhage1.35008962
61MP0001672_abnormal_embryogenesis/_devel1.33500032
62MP0005380_embryogenesis_phenotype1.33500032
63MP0001730_embryonic_growth_arrest1.33047845
64MP0003329_amyloid_beta_deposits1.32758047
65MP0005451_abnormal_body_composition1.30722591
66MP0003937_abnormal_limbs/digits/tail_de1.28959126
67MP0000383_abnormal_hair_follicle1.26787188
68MP0002085_abnormal_embryonic_tissue1.23656715
69MP0004142_abnormal_muscle_tone1.23464159
70MP0002396_abnormal_hematopoietic_system1.19848162
71MP0002229_neurodegeneration1.19398561
72MP0010094_abnormal_chromosome_stability1.19257487
73MP0005171_absent_coat_pigmentation1.19224640
74MP0002090_abnormal_vision1.18780424
75MP0002272_abnormal_nervous_system1.17096869
76MP0001697_abnormal_embryo_size1.16417114
77MP0003861_abnormal_nervous_system1.15878377
78MP0003984_embryonic_growth_retardation1.14157884
79MP0005248_abnormal_Harderian_gland1.13087881
80MP0002653_abnormal_ependyma_morphology1.13080811
81MP0004215_abnormal_myocardial_fiber1.12876797
82MP0002088_abnormal_embryonic_growth/wei1.11828741
83MP0000537_abnormal_urethra_morphology1.11261964
84MP0008932_abnormal_embryonic_tissue1.10309599
85MP0004134_abnormal_chest_morphology1.06923449
86MP0002938_white_spotting1.06241419
87MP0000955_abnormal_spinal_cord1.05122390
88MP0001986_abnormal_taste_sensitivity1.04317682
89MP0008260_abnormal_autophagy1.04254901
90MP0002009_preneoplasia1.03636801
91MP0004811_abnormal_neuron_physiology1.00887677
92MP0004197_abnormal_fetal_growth/weight/1.00843613
93MP0002735_abnormal_chemical_nociception0.98825570
94MP0000639_abnormal_adrenal_gland0.98607073
95MP0006072_abnormal_retinal_apoptosis0.97980117
96MP0000609_abnormal_liver_physiology0.97973226
97MP0002111_abnormal_tail_morphology0.97416883
98MP0003566_abnormal_cell_adhesion0.97319140
99MP0004381_abnormal_hair_follicle0.96011358
100MP0004272_abnormal_basement_membrane0.96006857
101MP0003631_nervous_system_phenotype0.95591514
102MP0001299_abnormal_eye_distance/0.94006044
103MP0003122_maternal_imprinting0.93986660
104MP0000613_abnormal_salivary_gland0.92634971
105MP0002837_dystrophic_cardiac_calcinosis0.92204987
106MP0001293_anophthalmia0.90352218
107MP0005220_abnormal_exocrine_pancreas0.90351229
108MP0005379_endocrine/exocrine_gland_phen0.90292358
109MP0008569_lethality_at_weaning0.89248983
110MP0000604_amyloidosis0.88989201
111MP0000350_abnormal_cell_proliferation0.88917221
112MP0000579_abnormal_nail_morphology0.86728001
113MP0003633_abnormal_nervous_system0.86247119
114MP0000428_abnormal_craniofacial_morphol0.86036301
115MP0004133_heterotaxia0.85106857
116MP0003943_abnormal_hepatobiliary_system0.84494574
117MP0008004_abnormal_stomach_pH0.83091939
118MP0001340_abnormal_eyelid_morphology0.82695935
119MP0002086_abnormal_extraembryonic_tissu0.82518496
120MP0001286_abnormal_eye_development0.82061049
121MP0003283_abnormal_digestive_organ0.81560874
122MP0001177_atelectasis0.81545290
123MP0005384_cellular_phenotype0.79051454
124MP0009672_abnormal_birth_weight0.79004937
125MP0002697_abnormal_eye_size0.78752350
126MP0002102_abnormal_ear_morphology0.78330270
127MP0002138_abnormal_hepatobiliary_system0.78041327
128MP0009765_abnormal_xenobiotic_induced0.77938385
129MP0002080_prenatal_lethality0.77814500
130MP0005195_abnormal_posterior_eye0.77729935
131MP0008007_abnormal_cellular_replicative0.77689239
132MP0004264_abnormal_extraembryonic_tissu0.77296689
133MP0001348_abnormal_lacrimal_gland0.76890176
134MP0001905_abnormal_dopamine_level0.76760322
135MP0005394_taste/olfaction_phenotype0.75822498
136MP0005499_abnormal_olfactory_system0.75822498
137MP0005187_abnormal_penis_morphology0.75756108
138MP0000647_abnormal_sebaceous_gland0.75173533
139MP0005584_abnormal_enzyme/coenzyme_acti0.74534535
140MP0005551_abnormal_eye_electrophysiolog0.73629781
141MP0008789_abnormal_olfactory_epithelium0.73457102
142MP0003935_abnormal_craniofacial_develop0.71976142
143MP0010630_abnormal_cardiac_muscle0.71657078
144MP0002882_abnormal_neuron_morphology0.70709476
145MP0010030_abnormal_orbit_morphology0.70674499
146MP0009053_abnormal_anal_canal0.69453558
147MP0002064_seizures0.68829670
148MP0000003_abnormal_adipose_tissue0.67156345
149MP0002233_abnormal_nose_morphology0.65650383
150MP0004019_abnormal_vitamin_homeostasis0.64578260
151MP0002092_abnormal_eye_morphology0.63074754
152MP0002066_abnormal_motor_capabilities/c0.62397026
153MP0001661_extended_life_span0.62235201
154MP0003121_genomic_imprinting0.61463489
155MP0005623_abnormal_meninges_morphology0.60916180
156MP0005058_abnormal_lysosome_morphology0.60858100
157MP0002734_abnormal_mechanical_nocicepti0.60099662
158MP0002752_abnormal_somatic_nervous0.57420211
159MP0002822_catalepsy0.56886576
160MP0001963_abnormal_hearing_physiology0.56587143
161MP0002152_abnormal_brain_morphology0.56533783
162MP0003119_abnormal_digestive_system0.56498638
163MP0005647_abnormal_sex_gland0.56436747
164MP0000467_abnormal_esophagus_morphology0.53929971
165MP0003938_abnormal_ear_development0.53886630
166MP0009703_decreased_birth_body0.53477795
167MP0003136_yellow_coat_color0.53283032

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.32216973
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.88588668
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.88588668
4Intrahepatic cholestasis (HP:0001406)5.64525641
5Neurofibrillary tangles (HP:0002185)4.68677865
6Abnormality of the corticospinal tract (HP:0002492)4.66802603
7Deep venous thrombosis (HP:0002625)4.24038994
8Hypobetalipoproteinemia (HP:0003563)3.87763396
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.76831342
10Parakeratosis (HP:0001036)3.76212973
11Abnormality of methionine metabolism (HP:0010901)3.67689487
12Xanthomatosis (HP:0000991)3.66039239
13Hyperlipoproteinemia (HP:0010980)3.62649646
14Prolonged partial thromboplastin time (HP:0003645)3.56201453
15Cerebral inclusion bodies (HP:0100314)3.55783007
16Termporal pattern (HP:0011008)3.41803715
17Insidious onset (HP:0003587)3.41803715
18Conjugated hyperbilirubinemia (HP:0002908)3.28488779
19Papillary thyroid carcinoma (HP:0002895)3.28465919
20Central scotoma (HP:0000603)3.25750142
21Epidermoid cyst (HP:0200040)3.22098341
22Spastic gait (HP:0002064)3.17251459
23Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.07127424
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.06933798
25Fat malabsorption (HP:0002630)3.06223480
26Hypoglycemic seizures (HP:0002173)2.99988978
27Sensory axonal neuropathy (HP:0003390)2.97624425
28Abnormality of sulfur amino acid metabolism (HP:0004339)2.94868153
29Peripheral hypomyelination (HP:0007182)2.93090258
30Pancreatic islet-cell hyperplasia (HP:0004510)2.91336764
31Biliary tract neoplasm (HP:0100574)2.91043129
32Hepatoblastoma (HP:0002884)2.89520469
33Alacrima (HP:0000522)2.88736291
34Coronal craniosynostosis (HP:0004440)2.88104838
35Onion bulb formation (HP:0003383)2.82817701
36Anteriorly placed anus (HP:0001545)2.79736575
37Hyperinsulinemic hypoglycemia (HP:0000825)2.77381058
38Abnormal auditory evoked potentials (HP:0006958)2.73501576
39Scotoma (HP:0000575)2.72919372
40Male infertility (HP:0003251)2.69441825
41Hypophosphatemic rickets (HP:0004912)2.66716256
42Thyroid carcinoma (HP:0002890)2.62570479
43Amyotrophic lateral sclerosis (HP:0007354)2.56935894
44Abnormality of the pancreatic islet cells (HP:0006476)2.56770016
45Abnormality of endocrine pancreas physiology (HP:0012093)2.56770016
46Abnormal respiratory epithelium morphology (HP:0012253)2.53286829
47Abnormal respiratory motile cilium morphology (HP:0005938)2.53286829
48Decreased lacrimation (HP:0000633)2.50911206
49Spastic diplegia (HP:0001264)2.50569209
50Morphological abnormality of the pyramidal tract (HP:0002062)2.50562797
51Intention tremor (HP:0002080)2.48699768
52Scanning speech (HP:0002168)2.45981906
53Rhinitis (HP:0012384)2.45638874
54Abnormality of the common coagulation pathway (HP:0010990)2.44678207
55Abnormality of the musculature of the pelvis (HP:0001469)2.44049287
56Abnormality of the hip-girdle musculature (HP:0001445)2.44049287
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.43233928
58Ependymoma (HP:0002888)2.42982566
59Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.42796024
60Hyperphosphatemia (HP:0002905)2.42766291
61Medial flaring of the eyebrow (HP:0010747)2.40937876
62Neoplasm of the small intestine (HP:0100833)2.40256133
63Agnosia (HP:0010524)2.38960972
64Increased circulating renin level (HP:0000848)2.38638370
65Hyperglycinemia (HP:0002154)2.38591518
66Split foot (HP:0001839)2.38368073
67Shoulder girdle muscle weakness (HP:0003547)2.38250947
68Steatorrhea (HP:0002570)2.34151666
69Transitional cell carcinoma of the bladder (HP:0006740)2.32713645
70Abnormal hair whorl (HP:0010721)2.32244518
71Hypolipoproteinemia (HP:0010981)2.32103775
72Multiple enchondromatosis (HP:0005701)2.31091304
73Ketosis (HP:0001946)2.31029809
74Medulloblastoma (HP:0002885)2.30046857
75Spastic tetraparesis (HP:0001285)2.28766982
76Slow saccadic eye movements (HP:0000514)2.28172770
77Abnormality of serine family amino acid metabolism (HP:0010894)2.27953745
78Abnormality of glycine metabolism (HP:0010895)2.27953745
79Hyperammonemia (HP:0001987)2.27117985
80Symptomatic seizures (HP:0011145)2.26819665
81Complement deficiency (HP:0004431)2.23451260
82Gonadotropin excess (HP:0000837)2.23374072
83Spastic paraparesis (HP:0002313)2.22076016
84Skull defect (HP:0001362)2.21732813
85Hypochromic microcytic anemia (HP:0004840)2.21677495
86Supranuclear gaze palsy (HP:0000605)2.20778958
87Turricephaly (HP:0000262)2.20628592
88Dysmetria (HP:0001310)2.18072712
89Hypomagnesemia (HP:0002917)2.16988888
90Vertebral arch anomaly (HP:0008438)2.16285278
91Hypoglycemic coma (HP:0001325)2.14555250
92Bladder neoplasm (HP:0009725)2.12764151
93Bladder carcinoma (HP:0002862)2.12764151
94Abnormal ciliary motility (HP:0012262)2.12545185
95Cerebral hypomyelination (HP:0006808)2.11417255
96Leukodystrophy (HP:0002415)2.08989538
97Drooling (HP:0002307)2.08570969
98Enlarged kidneys (HP:0000105)2.08067015
99Ankle clonus (HP:0011448)2.07526177
100Lower limb asymmetry (HP:0100559)2.06643383
101Rickets (HP:0002748)2.06611120
102Congenital primary aphakia (HP:0007707)2.05958731
103Abnormal respiratory motile cilium physiology (HP:0012261)2.05774199
104Choreoathetosis (HP:0001266)2.05741988
105Peripheral demyelination (HP:0011096)2.03548966
106Enlarged penis (HP:0000040)2.02889526
107Tetany (HP:0001281)2.02686269
108Neoplasm of the adrenal cortex (HP:0100641)2.01779532
109Cortical dysplasia (HP:0002539)2.01474474
110Spastic paraplegia (HP:0001258)1.99762092
111Abnormal biliary tract morphology (HP:0012440)1.99190343
112Clonus (HP:0002169)1.99188554
113Gait imbalance (HP:0002141)1.98883990
114Gastrointestinal carcinoma (HP:0002672)1.98519434
115Malignant gastrointestinal tract tumors (HP:0006749)1.98519434
116Pelvic girdle muscle weakness (HP:0003749)1.97587022
117Vaginal atresia (HP:0000148)1.95759662
118Genital tract atresia (HP:0001827)1.95574327
119Complete atrioventricular canal defect (HP:0001674)1.94687878
120Bifid scrotum (HP:0000048)1.94386663
121Curly hair (HP:0002212)1.93862193
122Thyroid-stimulating hormone excess (HP:0002925)1.92652530
123Abnormality of the intrinsic pathway (HP:0010989)1.92554797
124Nephrogenic diabetes insipidus (HP:0009806)1.91957881
125Infantile muscular hypotonia (HP:0008947)1.91801153
126Failure to thrive in infancy (HP:0001531)1.91453894
127Tetraparesis (HP:0002273)1.91110276
128Abnormality of glutamine family amino acid metabolism (HP:0010902)1.88680436
129Poor coordination (HP:0002370)1.88229206
130Abnormal pancreas size (HP:0012094)1.88166585
131Vascular calcification (HP:0004934)1.88046962
132Subaortic stenosis (HP:0001682)1.87917223
133Abnormality of the left ventricular outflow tract (HP:0011103)1.87917223
134Hypercholesterolemia (HP:0003124)1.87817222
135Supernumerary spleens (HP:0009799)1.86298230
136Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85349473
137Neoplasm of the rectum (HP:0100743)1.84589391
138Thickened helices (HP:0000391)1.83687258
139Myelomeningocele (HP:0002475)1.83670082
140Acanthocytosis (HP:0001927)1.83354210
141Abnormality of calcium-phosphate metabolism (HP:0100530)1.83345290
142Intestinal atresia (HP:0011100)1.83324358
143Megalencephaly (HP:0001355)1.82580385
144Abnormality of vitamin metabolism (HP:0100508)1.82306334
145Abnormality of the lower motor neuron (HP:0002366)1.81264681
146Broad foot (HP:0001769)1.81204605
147Astrocytoma (HP:0009592)1.81100188
148Abnormality of the astrocytes (HP:0100707)1.81100188
149Mild short stature (HP:0003502)1.80991873
150Paraparesis (HP:0002385)1.80603326
151Excessive salivation (HP:0003781)1.80020815
152Cupped ear (HP:0000378)1.79708146
153Uterine neoplasm (HP:0010784)1.79027905
154Hypoplastic pelvis (HP:0008839)1.78469204
155Abnormality of glycolysis (HP:0004366)1.78424328
156Increased serum pyruvate (HP:0003542)1.78424328
157Atrioventricular canal defect (HP:0006695)1.77945335
158Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77620753
159Stridor (HP:0010307)1.77560436
160Colon cancer (HP:0003003)1.76748663
161Lower limb muscle weakness (HP:0007340)1.76292973
162Back pain (HP:0003418)1.75985429
163Adactyly (HP:0009776)1.75507823
164Paraplegia (HP:0010550)1.75108729
165Decreased motor nerve conduction velocity (HP:0003431)1.75067665
166Abnormal gallbladder morphology (HP:0012437)1.75045316
167Septo-optic dysplasia (HP:0100842)1.74563660
168Hepatocellular carcinoma (HP:0001402)1.73821481
169Irritability (HP:0000737)1.73640504
170Progressive external ophthalmoplegia (HP:0000590)1.73558135
171Joint hemorrhage (HP:0005261)1.72490910
172Skin nodule (HP:0200036)1.72409643
173Urinary urgency (HP:0000012)1.72305783
174Neoplasm of the adrenal gland (HP:0100631)1.72073049
175Methylmalonic acidemia (HP:0002912)1.70862948
176Urinary incontinence (HP:0000020)1.69745410
177Elevated alkaline phosphatase (HP:0003155)1.68337533
178Segmental peripheral demyelination/remyelination (HP:0003481)1.67881283
179Delayed CNS myelination (HP:0002188)1.67676606
180Opisthotonus (HP:0002179)1.67327751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.46336600
2OXSR13.43511776
3EPHB13.18527906
4MET3.07905200
5FGFR23.05699472
6STK38L2.83704616
7BCR2.77231903
8LMTK22.75165881
9CASK2.53485171
10PBK2.47339929
11PKN12.39301125
12EIF2AK32.25146821
13STK32.24908827
14WNK12.21911731
15SRPK12.20969845
16ICK2.13923335
17CSNK1A1L2.12729962
18WNK42.12259826
19MAPKAPK52.05867929
20INSRR1.97829334
21MKNK21.94037886
22CSNK1G31.92606355
23TTK1.92340724
24UHMK11.91020616
25SGK4941.63873123
26SGK2231.63873123
27ERBB41.63396096
28FGFR31.62862941
29CSNK1G11.62425504
30MST41.54433888
31PLK31.52861179
32CSNK1G21.44627596
33PLK21.41775074
34TIE11.40613770
35LATS21.40603740
36TSSK61.39773599
37TESK21.39107008
38FRK1.38436371
39MAPK151.34936345
40TAF11.32642243
41PAK31.31173392
42NEK61.28736753
43PNCK1.27805956
44NTRK11.25065429
45CAMK2B1.24654128
46TRIM281.24206189
47FGFR41.23790037
48TEC1.22480011
49SIK11.21380661
50NEK91.20397724
51LIMK11.18308592
52ALK1.17759583
53NLK1.16567137
54TYRO31.14765275
55FGR1.13160072
56NTRK31.08727670
57PDGFRA1.07704252
58MARK21.06391967
59PLK41.06017314
60KSR21.05045402
61CDC71.04998371
62PRPF4B1.03177999
63BRD41.02050615
64CDK61.01886497
65PAK60.99140496
66LATS10.98338274
67DYRK1A0.97582106
68STK240.96567723
69ERBB30.96396548
70CLK10.95851761
71YES10.95781527
72BMPR1B0.95742272
73CDK30.94410033
74RPS6KA40.92845783
75KSR10.91393674
76CAMK2G0.91350121
77DYRK20.91060655
78STK40.90410117
79CAMK2D0.89234642
80CDK120.88823235
81TAOK30.86715688
82PRKCQ0.86478850
83PASK0.84715802
84EPHA40.84539493
85BCKDK0.83969825
86GSK3A0.81282640
87CAMK1G0.80800278
88SCYL20.80427381
89CDK190.80353792
90IRAK20.79747879
91TNIK0.79371295
92MELK0.76971527
93FGFR10.76259110
94MAP3K60.74759428
95ROCK20.73473394
96ATM0.73407799
97ITK0.73301460
98CSNK1D0.73161464
99HIPK20.72136667
100PRKD10.71851599
101PLK10.71487186
102MKNK10.67327311
103PRKD30.64108084
104RPS6KA50.63963327
105WEE10.62690978
106NTRK20.62008369
107ERBB20.60606193
108PDGFRB0.60163575
109EPHA30.58576725
110PRKCH0.55657827
111DYRK30.55207755
112PDK20.55022508
113SGK20.54584459
114PRKCG0.54231705
115MAP3K100.53910760
116ZAK0.53794490
117EGFR0.52375302
118STK380.49940499
119MARK10.48781177
120PTK60.48045483
121EIF2AK20.47984001
122ATR0.47637016
123PTK20.47422079
124CSNK1E0.47348199
125RET0.46662715
126CAMK2A0.46170367
127CSNK1A10.45913276
128ADRBK20.45409860
129PRKCE0.44801435
130PDPK10.43975925
131DDR20.43579058
132RAF10.43402496
133PRKG10.43205202
134CDK50.43033587
135IRAK10.42968680
136MAP2K20.42839250
137FES0.42595219
138BRSK20.42166579
139CHEK10.41010934
140ACVR1B0.40707205
141TGFBR10.39779265
142INSR0.39646617
143BMPR20.39589374
144RPS6KB10.39500443
145MAP3K40.39460573
146MAP3K130.39114225
147CDK140.38079530
148FYN0.37670268
149MAP3K70.35879599
150PRKACB0.35515776
151MAP3K20.35247099
152MAPK100.34957362
153MAP2K70.34893244
154BMX0.34613151
155CAMK1D0.34486278
156WNK30.34332140
157AKT30.34293817
158MAPK70.33256830
159MTOR0.33199153
160RIPK10.33116447
161FLT30.32435726
162MAPK10.31489805

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.06401763
2Steroid biosynthesis_Homo sapiens_hsa001003.94411173
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.51246477
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.49507728
5Fatty acid elongation_Homo sapiens_hsa000623.29023732
6Primary bile acid biosynthesis_Homo sapiens_hsa001203.26641842
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.93257161
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58987362
9Butanoate metabolism_Homo sapiens_hsa006502.45265958
10Histidine metabolism_Homo sapiens_hsa003402.44726933
11Non-homologous end-joining_Homo sapiens_hsa034502.42216857
12Sulfur metabolism_Homo sapiens_hsa009202.40472389
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.30112841
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.16848589
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.15100854
16Arginine biosynthesis_Homo sapiens_hsa002202.11651060
17Tryptophan metabolism_Homo sapiens_hsa003802.09326113
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.97562689
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92157234
20mRNA surveillance pathway_Homo sapiens_hsa030151.90177139
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.84945917
22Circadian rhythm_Homo sapiens_hsa047101.74298454
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70571501
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70385216
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70014964
26Mismatch repair_Homo sapiens_hsa034301.67819199
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67245375
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66985314
29Peroxisome_Homo sapiens_hsa041461.65181525
30Complement and coagulation cascades_Homo sapiens_hsa046101.62419238
31Fatty acid metabolism_Homo sapiens_hsa012121.52880717
32RNA transport_Homo sapiens_hsa030131.52859824
33Folate biosynthesis_Homo sapiens_hsa007901.51974288
34Chemical carcinogenesis_Homo sapiens_hsa052041.48181078
35Propanoate metabolism_Homo sapiens_hsa006401.47990565
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47762835
37Fatty acid degradation_Homo sapiens_hsa000711.47536064
38Ether lipid metabolism_Homo sapiens_hsa005651.47472866
39Notch signaling pathway_Homo sapiens_hsa043301.44100051
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41908008
41Cell cycle_Homo sapiens_hsa041101.41505400
42Arginine and proline metabolism_Homo sapiens_hsa003301.41475198
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40167504
44Retinol metabolism_Homo sapiens_hsa008301.35593594
45Inositol phosphate metabolism_Homo sapiens_hsa005621.28762803
46Oocyte meiosis_Homo sapiens_hsa041141.28537333
47Tyrosine metabolism_Homo sapiens_hsa003501.28362453
48Vitamin B6 metabolism_Homo sapiens_hsa007501.27589102
49Adherens junction_Homo sapiens_hsa045201.25564744
50Regulation of autophagy_Homo sapiens_hsa041401.22272597
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20964234
52Selenocompound metabolism_Homo sapiens_hsa004501.20523870
53beta-Alanine metabolism_Homo sapiens_hsa004101.17951671
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16810170
55Bile secretion_Homo sapiens_hsa049761.15644224
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15589845
57Protein export_Homo sapiens_hsa030601.14574171
58RNA degradation_Homo sapiens_hsa030181.13166795
59ABC transporters_Homo sapiens_hsa020101.07639429
60Spliceosome_Homo sapiens_hsa030401.07220863
61Colorectal cancer_Homo sapiens_hsa052101.06777446
62Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05958625
63Endometrial cancer_Homo sapiens_hsa052131.05590161
64Fat digestion and absorption_Homo sapiens_hsa049751.05287672
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01340187
66Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00982186
67Thyroid cancer_Homo sapiens_hsa052160.99645227
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99046916
69Nucleotide excision repair_Homo sapiens_hsa034200.98449634
70Linoleic acid metabolism_Homo sapiens_hsa005910.98066892
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97815131
72PPAR signaling pathway_Homo sapiens_hsa033200.97216292
73MicroRNAs in cancer_Homo sapiens_hsa052060.96184089
74Lysine degradation_Homo sapiens_hsa003100.94476256
75Fanconi anemia pathway_Homo sapiens_hsa034600.92450065
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91866812
77TGF-beta signaling pathway_Homo sapiens_hsa043500.91504876
78DNA replication_Homo sapiens_hsa030300.90810609
79Basal transcription factors_Homo sapiens_hsa030220.90320124
80Phenylalanine metabolism_Homo sapiens_hsa003600.89119981
81mTOR signaling pathway_Homo sapiens_hsa041500.88097230
82p53 signaling pathway_Homo sapiens_hsa041150.87855143
83Glutamatergic synapse_Homo sapiens_hsa047240.85872345
84Gastric acid secretion_Homo sapiens_hsa049710.85533535
85Pyruvate metabolism_Homo sapiens_hsa006200.81240561
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.81110133
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.78670893
88Vitamin digestion and absorption_Homo sapiens_hsa049770.77759135
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.75224703
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74376698
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74360144
92Axon guidance_Homo sapiens_hsa043600.73112691
93Chronic myeloid leukemia_Homo sapiens_hsa052200.72264830
94Circadian entrainment_Homo sapiens_hsa047130.71780213
95Dopaminergic synapse_Homo sapiens_hsa047280.71216834
96Taste transduction_Homo sapiens_hsa047420.70532772
97AMPK signaling pathway_Homo sapiens_hsa041520.70096296
98Long-term potentiation_Homo sapiens_hsa047200.69843036
99Base excision repair_Homo sapiens_hsa034100.69474967
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69069114
101Gap junction_Homo sapiens_hsa045400.67882113
102ECM-receptor interaction_Homo sapiens_hsa045120.67312023
103Melanogenesis_Homo sapiens_hsa049160.66565532
104Prolactin signaling pathway_Homo sapiens_hsa049170.66556046
105Staphylococcus aureus infection_Homo sapiens_hsa051500.66119634
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63860606
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63614464
108Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59968849
109Choline metabolism in cancer_Homo sapiens_hsa052310.59642468
110Small cell lung cancer_Homo sapiens_hsa052220.59125112
111Starch and sucrose metabolism_Homo sapiens_hsa005000.57127842
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56811443
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56086347
114Estrogen signaling pathway_Homo sapiens_hsa049150.55953112
115Glutathione metabolism_Homo sapiens_hsa004800.55658056
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55353960
117Rap1 signaling pathway_Homo sapiens_hsa040150.53028093
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52436170
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51456292
120N-Glycan biosynthesis_Homo sapiens_hsa005100.50446912
121Nicotine addiction_Homo sapiens_hsa050330.47926685
122Sphingolipid metabolism_Homo sapiens_hsa006000.47873508
123Glycerolipid metabolism_Homo sapiens_hsa005610.45882299
124Fatty acid biosynthesis_Homo sapiens_hsa000610.43840731
125Prion diseases_Homo sapiens_hsa050200.41734050
126Renal cell carcinoma_Homo sapiens_hsa052110.41052408
127Metabolic pathways_Homo sapiens_hsa011000.38982757
128Biosynthesis of amino acids_Homo sapiens_hsa012300.38304907
129One carbon pool by folate_Homo sapiens_hsa006700.35899736
130Cocaine addiction_Homo sapiens_hsa050300.33526431
131Caffeine metabolism_Homo sapiens_hsa002320.33409911
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.33322124
133Ovarian steroidogenesis_Homo sapiens_hsa049130.32228006
134Tight junction_Homo sapiens_hsa045300.30710930
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28990317
136GABAergic synapse_Homo sapiens_hsa047270.27285908
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26536566
138Hedgehog signaling pathway_Homo sapiens_hsa043400.26066112
139Basal cell carcinoma_Homo sapiens_hsa052170.25224159
140Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.18987300
141Dorso-ventral axis formation_Homo sapiens_hsa043200.18100214
142Type II diabetes mellitus_Homo sapiens_hsa049300.15823671
143ErbB signaling pathway_Homo sapiens_hsa040120.13885334
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12431306
145Serotonergic synapse_Homo sapiens_hsa047260.11079601
146Autoimmune thyroid disease_Homo sapiens_hsa053200.10806927
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10763930
148Ras signaling pathway_Homo sapiens_hsa040140.10749588
149Hippo signaling pathway_Homo sapiens_hsa043900.09825198
150Mineral absorption_Homo sapiens_hsa049780.09571819
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.09494356
152Prostate cancer_Homo sapiens_hsa052150.09402929
153Carbon metabolism_Homo sapiens_hsa012000.08386545
154SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08015611
155Long-term depression_Homo sapiens_hsa047300.07982235
156Insulin secretion_Homo sapiens_hsa049110.04922461
157Thyroid hormone synthesis_Homo sapiens_hsa049180.04910618
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.02969257
159Wnt signaling pathway_Homo sapiens_hsa043100.01060403
160Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.00245087
161Pancreatic secretion_Homo sapiens_hsa04972-0.0211129
162Lysosome_Homo sapiens_hsa04142-0.0207601

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