RCBTB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.82269984
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.28127817
3negative regulation of cell killing (GO:0031342)5.28127817
4negative regulation of interleukin-12 production (GO:0032695)4.96507223
5detection of other organism (GO:0098543)4.40953779
6positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.30683384
7positive regulation of mast cell activation (GO:0033005)4.28564030
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.23694274
9detection of external biotic stimulus (GO:0098581)4.05635537
10detection of bacterium (GO:0016045)3.86610979
11neutrophil activation (GO:0042119)3.84626366
12positive regulation of mast cell degranulation (GO:0043306)3.79762853
13positive regulation of mast cell activation involved in immune response (GO:0033008)3.79762853
14regulation of mast cell degranulation (GO:0043304)3.73092667
15regulation of mast cell activation (GO:0033003)3.71072379
16granulocyte activation (GO:0036230)3.70758500
17macrophage activation (GO:0042116)3.67189074
18detection of biotic stimulus (GO:0009595)3.64372154
19neutrophil mediated immunity (GO:0002446)3.63292820
20response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.61750860
21response to host immune response (GO:0052572)3.61750860
22negative T cell selection (GO:0043383)3.55056711
23regulation of mast cell activation involved in immune response (GO:0033006)3.54925418
24negative thymic T cell selection (GO:0045060)3.52738662
25amino sugar catabolic process (GO:0046348)3.50927216
26negative regulation of interleukin-1 beta production (GO:0032691)3.49050405
27definitive hemopoiesis (GO:0060216)3.48573635
28positive regulation of cellular amide metabolic process (GO:0034250)3.45596602
29response to interleukin-15 (GO:0070672)3.44707411
30cellular response to interleukin-15 (GO:0071350)3.39035100
31positive regulation by symbiont of host defense response (GO:0052509)3.35541264
32modulation by symbiont of host defense response (GO:0052031)3.35541264
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.35541264
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.35541264
35positive regulation by organism of defense response of other organism involved in symbiotic interact3.35541264
36modulation by symbiont of host immune response (GO:0052553)3.35541264
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.33593838
38negative regulation of phagocytosis (GO:0050765)3.32201729
39myeloid leukocyte mediated immunity (GO:0002444)3.30558152
40interferon-gamma production (GO:0032609)3.25627862
41negative regulation of interleukin-1 production (GO:0032692)3.24595306
42tolerance induction (GO:0002507)3.21920729
43regulation of T cell tolerance induction (GO:0002664)3.21818161
44T cell migration (GO:0072678)3.19534702
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.17791409
46regulation of interferon-beta biosynthetic process (GO:0045357)3.17157856
47regulation of myeloid leukocyte mediated immunity (GO:0002886)3.17113834
48positive regulation of interferon-alpha production (GO:0032727)3.16871121
49interferon-gamma-mediated signaling pathway (GO:0060333)3.16594716
50histamine secretion (GO:0001821)3.15808344
51regulation of tolerance induction (GO:0002643)3.15184175
52negative regulation of T cell mediated immunity (GO:0002710)3.12598483
53regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.12433070
54regulation of leukocyte degranulation (GO:0043300)3.11101096
55regulation of B cell receptor signaling pathway (GO:0050855)3.09733595
56leukocyte migration involved in inflammatory response (GO:0002523)3.09485984
57activated T cell proliferation (GO:0050798)3.09149921
58positive regulation of macrophage cytokine production (GO:0060907)3.08268399
59negative regulation of leukocyte mediated immunity (GO:0002704)3.07851223
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.07627393
61leukocyte aggregation (GO:0070486)3.07427080
62negative regulation of granulocyte differentiation (GO:0030853)3.05672152
63B cell receptor signaling pathway (GO:0050853)3.03289899
64positive regulation of gamma-delta T cell activation (GO:0046645)3.02244671
65positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.99865216
66positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.99392433
67lipopolysaccharide-mediated signaling pathway (GO:0031663)2.99227003
68T-helper 1 type immune response (GO:0042088)2.98290283
69regulation of interferon-alpha production (GO:0032647)2.96225165
70pinocytosis (GO:0006907)2.92480016
71regulation of germinal center formation (GO:0002634)2.92362966
72germinal center formation (GO:0002467)2.90620547
73positive regulation of B cell differentiation (GO:0045579)2.90269566
74leukocyte degranulation (GO:0043299)2.90080477
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.88611628
76positive regulation of leukocyte degranulation (GO:0043302)2.86865894
77T cell selection (GO:0045058)2.86146680
78myeloid leukocyte activation (GO:0002274)2.85379762
79negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.85291812
80N-acetylneuraminate metabolic process (GO:0006054)2.83613829
81neutrophil chemotaxis (GO:0030593)2.82565939
82regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.78451748
83positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.76867880
84immunoglobulin mediated immune response (GO:0016064)2.73310677
85DNA unwinding involved in DNA replication (GO:0006268)2.71239880
86positive regulation of macrophage differentiation (GO:0045651)2.69094339
87regulation of cholesterol storage (GO:0010885)2.65649916
88platelet dense granule organization (GO:0060155)2.53553216
89macrophage activation involved in immune response (GO:0002281)2.53187302
90neutrophil activation involved in immune response (GO:0002283)2.52133246
91B cell mediated immunity (GO:0019724)2.49933666
92positive regulation of protein import into nucleus, translocation (GO:0033160)2.46101442
93kinetochore organization (GO:0051383)2.45996534
94outer ear morphogenesis (GO:0042473)2.45870888
95positive regulation of chemokine secretion (GO:0090197)2.44489885
96antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.44444002
97antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.44444002
98positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.44366239
99germ cell migration (GO:0008354)2.41925992
100response to peptidoglycan (GO:0032494)2.39101001
101regulation of macrophage differentiation (GO:0045649)2.38023625
102phagocytosis, engulfment (GO:0006911)2.36671339
103cellular extravasation (GO:0045123)2.32334393
104response to muramyl dipeptide (GO:0032495)2.32327169
105production of molecular mediator involved in inflammatory response (GO:0002532)2.31696816
106positive regulation of hemostasis (GO:1900048)2.29306221
107positive regulation of blood coagulation (GO:0030194)2.29306221
108respiratory burst (GO:0045730)2.29002052
109positive regulation of antigen processing and presentation (GO:0002579)2.28771980
110DNA topological change (GO:0006265)2.26855690
111triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.26492481
1123-UTR-mediated mRNA stabilization (GO:0070935)2.25840628
113positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.25623028
114regulation of gamma-delta T cell differentiation (GO:0045586)2.25459592
115negative regulation of mast cell activation (GO:0033004)2.25096770
116ribosomal small subunit assembly (GO:0000028)2.23545331
117positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.23472375
118polyketide metabolic process (GO:0030638)2.23431064
119doxorubicin metabolic process (GO:0044598)2.23431064
120daunorubicin metabolic process (GO:0044597)2.23431064
121detection of molecule of bacterial origin (GO:0032490)2.21412985
122positive regulation of coagulation (GO:0050820)2.21364537
123regulation of B cell differentiation (GO:0045577)2.20850402
124dendritic cell chemotaxis (GO:0002407)2.20533974
125positive regulation of erythrocyte differentiation (GO:0045648)2.17994351
126regulation of gamma-delta T cell activation (GO:0046643)2.17990252
127myeloid cell activation involved in immune response (GO:0002275)2.14319997
128positive regulation of monocyte chemotaxis (GO:0090026)2.12918733
129I-kappaB phosphorylation (GO:0007252)2.12284625
130epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.12116931
131positive regulation of interferon-beta production (GO:0032728)2.11658765
132microglial cell activation (GO:0001774)2.10912567
133myeloid dendritic cell activation (GO:0001773)2.09482300
134response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.09108727
135response to host (GO:0075136)2.09108727
136response to host defenses (GO:0052200)2.09108727
137cell proliferation involved in metanephros development (GO:0072203)2.08771534
138antigen processing and presentation of endogenous antigen (GO:0019883)2.07968821
139response to interferon-alpha (GO:0035455)2.07783401
140mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.06847751
141aldehyde catabolic process (GO:0046185)2.06787778
142secretory granule organization (GO:0033363)2.02900433
143hyaluronan catabolic process (GO:0030214)2.02846199
144Arp2/3 complex-mediated actin nucleation (GO:0034314)2.02297743
145negative regulation of lipid storage (GO:0010888)2.01567042
146antigen processing and presentation via MHC class Ib (GO:0002475)1.99900350
147regulation of mononuclear cell migration (GO:0071675)1.99636869
148dendritic cell migration (GO:0036336)1.98780123
149positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)1.98498772
150protein carboxylation (GO:0018214)1.98074402
151peptidyl-glutamic acid carboxylation (GO:0017187)1.98074402
152positive regulation of fatty acid beta-oxidation (GO:0032000)1.97999628
153positive regulation of heterotypic cell-cell adhesion (GO:0034116)1.96661765
154low-density lipoprotein particle clearance (GO:0034383)1.95409324
155positive regulation of macrophage derived foam cell differentiation (GO:0010744)1.95302384
156negative regulation of macrophage differentiation (GO:0045650)1.95301394
157alpha-linolenic acid metabolic process (GO:0036109)1.93273531
158regulation of MHC class II biosynthetic process (GO:0045346)1.92913031
159positive regulation of tumor necrosis factor production (GO:0032760)1.92412097
160plasma lipoprotein particle clearance (GO:0034381)1.92366576
161meiotic chromosome segregation (GO:0045132)1.92069354
162endothelial tube morphogenesis (GO:0061154)1.91522885
163morphogenesis of an endothelium (GO:0003159)1.91522885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.54241258
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.12396575
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.10062640
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.70666728
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.48581449
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.40437396
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.12157631
8* SCL_19346495_ChIP-Seq_HPC-7_Human2.89966959
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.84693363
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83978794
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70095077
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.68324562
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62961955
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52492990
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.51550785
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49693737
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.47852387
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44430477
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41909979
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34607425
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33607678
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26646655
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12220918
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.09750801
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.08079959
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06540104
27SPI1_23547873_ChIP-Seq_NB4_Human1.99865083
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98161891
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95951101
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93354257
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.89877490
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87884404
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.87619950
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86472234
35* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85392364
36VDR_21846776_ChIP-Seq_THP-1_Human1.84843895
37GATA3_27048872_Chip-Seq_THYMUS_Human1.84138738
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83985992
39* MYC_22102868_ChIP-Seq_BL_Human1.79369100
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77867689
41* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77397371
42* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77382753
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74420030
44GATA3_26560356_Chip-Seq_TH2_Human1.73838129
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72536942
46CLOCK_20551151_ChIP-Seq_293T_Human1.68305864
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67494396
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66455399
49* RXR_22158963_ChIP-Seq_LIVER_Mouse1.65110549
50GATA1_22025678_ChIP-Seq_K562_Human1.64173690
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60558762
52MAF_26560356_Chip-Seq_TH1_Human1.59743831
53MYB_26560356_Chip-Seq_TH2_Human1.58311946
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.57733058
55* VDR_24763502_ChIP-Seq_THP-1_Human1.56837333
56* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55427852
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55099369
58AR_21909140_ChIP-Seq_LNCAP_Human1.51426828
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47997305
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.45273139
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43711091
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43558202
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43157809
64RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37810957
65* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36559540
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36045088
67* RUNX_20019798_ChIP-Seq_JUKART_Human1.35396000
68* MYB_26560356_Chip-Seq_TH1_Human1.34661532
69* LXR_22158963_ChIP-Seq_LIVER_Mouse1.33534756
70UTX_26944678_Chip-Seq_JUKART_Human1.33419513
71PU_27001747_Chip-Seq_BMDM_Mouse1.31961967
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.30340783
73* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29842105
74* TCF7_22412390_ChIP-Seq_EML_Mouse1.29730589
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29632492
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28874728
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28071128
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26122673
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25908079
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23147526
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22809840
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20454000
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18830379
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.18688993
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15839328
86SMRT_27268052_Chip-Seq_Bcells_Human1.14858197
87VDR_24787735_ChIP-Seq_THP-1_Human1.14856153
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14392043
89ELK1_19687146_ChIP-ChIP_HELA_Human1.11239580
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09708768
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08149447
92CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07846208
93XRN2_22483619_ChIP-Seq_HELA_Human1.04243388
94* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03614858
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03402389
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02384025
97SPI1_23127762_ChIP-Seq_K562_Human1.02084218
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01800963
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.01132703
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00940679
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00734805
102ELK3_25401928_ChIP-Seq_HUVEC_Human1.00150388
103* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99144498
104NOTCH1_21737748_ChIP-Seq_TLL_Human0.98141751
105CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97486299
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96460325
107* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95549554
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95356754
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93948901
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93138852
111CIITA_25753668_ChIP-Seq_RAJI_Human0.92840655
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.92301262
113GATA2_21666600_ChIP-Seq_HMVEC_Human0.91395815
114MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91022493
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90804497
116MAF_26560356_Chip-Seq_TH2_Human0.90497531
117EZH2_27294783_Chip-Seq_NPCs_Mouse0.87896970
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87249208
119TFEB_21752829_ChIP-Seq_HELA_Human0.87012431
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86952936
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86308108
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86157569
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85851081
124* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85192299
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84790385
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84567140
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81889566
128FOXP3_21729870_ChIP-Seq_TREG_Human0.81595662
129WT1_19549856_ChIP-ChIP_CCG9911_Human0.81438604
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81019312
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80589598
132GATA3_26560356_Chip-Seq_TH1_Human0.79360426
133KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.76535842
134PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76004556
135NFE2_27457419_Chip-Seq_LIVER_Mouse0.74198612
136GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73284836
137POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72917089
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.72698408
139BCAT_22108803_ChIP-Seq_LS180_Human0.71446193
140OCT4_21477851_ChIP-Seq_ESCs_Mouse0.70131747
141SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.67534580
142SALL4_22934838_ChIP-ChIP_CD34+_Human0.67332087
143PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.64903835
144CRX_20693478_ChIP-Seq_RETINA_Mouse0.64383525
145NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64360271

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003172_abnormal_lysosome_physiology2.98060155
2MP0001835_abnormal_antigen_presentation2.74613258
3MP0003436_decreased_susceptibility_to2.47597588
4MP0003191_abnormal_cellular_cholesterol2.28615765
5MP0002009_preneoplasia2.23208858
6MP0008438_abnormal_cutaneous_collagen2.17866844
7MP0006054_spinal_hemorrhage2.05465423
8MP0004808_abnormal_hematopoietic_stem2.01420006
9MP0001879_abnormal_lymphatic_vessel2.01146447
10MP0002419_abnormal_innate_immunity1.95096886
11MP0003690_abnormal_glial_cell1.94334219
12MP0009785_altered_susceptibility_to1.90521861
13MP0010368_abnormal_lymphatic_system1.90232715
14MP0000569_abnormal_digit_pigmentation1.87070796
15MP0002396_abnormal_hematopoietic_system1.84741953
16MP0008007_abnormal_cellular_replicative1.83280637
17MP0009278_abnormal_bone_marrow1.81023964
18MP0003724_increased_susceptibility_to1.78691108
19MP0009697_abnormal_copulation1.78548469
20MP0002452_abnormal_antigen_presenting1.71192128
21MP0005058_abnormal_lysosome_morphology1.70775532
22MP0005464_abnormal_platelet_physiology1.70729971
23MP0002148_abnormal_hypersensitivity_rea1.70289711
24MP0005174_abnormal_tail_pigmentation1.70132241
25MP0000604_amyloidosis1.68917483
26MP0005025_abnormal_response_to1.68226094
27MP0005671_abnormal_response_to1.67803410
28MP0006082_CNS_inflammation1.67257212
29MP0005167_abnormal_blood-brain_barrier1.66928716
30MP0004947_skin_inflammation1.62287779
31MP0003705_abnormal_hypodermis_morpholog1.60637706
32MP0008260_abnormal_autophagy1.59204765
33MP0005000_abnormal_immune_tolerance1.57425850
34MP0000343_altered_response_to1.55684072
35MP0001800_abnormal_humoral_immune1.55434143
36MP0003303_peritoneal_inflammation1.54157883
37MP0003787_abnormal_imprinting1.53164806
38MP0003075_altered_response_to1.50748331
39MP0000685_abnormal_immune_system1.50563322
40MP0002723_abnormal_immune_serum1.50482278
41MP0002420_abnormal_adaptive_immunity1.45552670
42MP0001819_abnormal_immune_cell1.44915752
43MP0009053_abnormal_anal_canal1.43606394
44MP0001853_heart_inflammation1.41891765
45MP0003656_abnormal_erythrocyte_physiolo1.41569511
46MP0002405_respiratory_system_inflammati1.41343986
47MP0004381_abnormal_hair_follicle1.41002487
48MP0003195_calcinosis1.37816571
49MP0010030_abnormal_orbit_morphology1.35882075
50MP0003279_aneurysm1.33762602
51MP0002398_abnormal_bone_marrow1.33665927
52MP0005397_hematopoietic_system_phenotyp1.32830325
53MP0001545_abnormal_hematopoietic_system1.32830325
54MP0005365_abnormal_bile_salt1.31391104
55MP0005248_abnormal_Harderian_gland1.30256973
56MP0004883_abnormal_blood_vessel1.30137286
57MP0001533_abnormal_skeleton_physiology1.29552044
58MP0008877_abnormal_DNA_methylation1.26518700
59MP0005310_abnormal_salivary_gland1.25571781
60MP0000689_abnormal_spleen_morphology1.23564127
61MP0003763_abnormal_thymus_physiology1.22917997
62MP0001790_abnormal_immune_system1.22915279
63MP0005387_immune_system_phenotype1.22915279
64MP0003183_abnormal_peptide_metabolism1.21739969
65MP0010094_abnormal_chromosome_stability1.21506106
66MP0000716_abnormal_immune_system1.20483908
67MP0010329_abnormal_lipoprotein_level1.20356001
68MP0002722_abnormal_immune_system1.19540855
69MP0003186_abnormal_redox_activity1.19402815
70MP0002277_abnormal_respiratory_mucosa1.18984420
71MP0000490_abnormal_crypts_of1.18153065
72MP0000465_gastrointestinal_hemorrhage1.16951548
73MP0001845_abnormal_inflammatory_respons1.16626806
74MP0005670_abnormal_white_adipose1.15316859
75MP0003300_gastrointestinal_ulcer1.12585297
76MP0003077_abnormal_cell_cycle1.11605071
77MP0008469_abnormal_protein_level1.11468442
78MP0010155_abnormal_intestine_physiology1.11297590
79MP0002429_abnormal_blood_cell1.11170235
80MP0001915_intracranial_hemorrhage1.11058358
81MP0009333_abnormal_splenocyte_physiolog1.07410759
82MP0003828_pulmonary_edema1.06344848
83MP0002139_abnormal_hepatobiliary_system1.06027505
84MP0000767_abnormal_smooth_muscle1.04095587
85MP0005360_urolithiasis1.04088956
86MP0010307_abnormal_tumor_latency1.03327124
87MP0000703_abnormal_thymus_morphology1.02423175
88MP0002998_abnormal_bone_remodeling1.01462860
89MP0003252_abnormal_bile_duct1.01249333
90MP0009764_decreased_sensitivity_to1.00196663
91MP0009763_increased_sensitivity_to0.99526468
92MP0000598_abnormal_liver_morphology0.99156119
93MP0005075_abnormal_melanosome_morpholog0.96528307
94MP0003943_abnormal_hepatobiliary_system0.96326533
95MP0004510_myositis0.95978796
96MP0000920_abnormal_myelination0.94031670
97MP0000858_altered_metastatic_potential0.93888166
98MP0002166_altered_tumor_susceptibility0.93222074
99MP0000609_abnormal_liver_physiology0.92330051
100MP0009840_abnormal_foam_cell0.91925912
101MP0002933_joint_inflammation0.91445884
102MP0005390_skeleton_phenotype0.90739372
103MP0005076_abnormal_cell_differentiation0.90587684
104MP0003448_altered_tumor_morphology0.88798316
105MP0008057_abnormal_DNA_replication0.87920986
106MP0002938_white_spotting0.87504440
107MP0000249_abnormal_blood_vessel0.87424487
108MP0003795_abnormal_bone_structure0.87348185
109MP0000733_abnormal_muscle_development0.85967757
110MP0005166_decreased_susceptibility_to0.85925843
111MP0009115_abnormal_fat_cell0.84331163
112MP0008058_abnormal_DNA_repair0.83907428
113MP0002128_abnormal_blood_circulation0.83584757
114MP0005023_abnormal_wound_healing0.83382313
115MP0002006_tumorigenesis0.82686784
116MP0000371_diluted_coat_color0.81204073
117MP0003221_abnormal_cardiomyocyte_apopto0.80301258
118MP0003385_abnormal_body_wall0.79854906
119MP0003566_abnormal_cell_adhesion0.79396532
120MP0001851_eye_inflammation0.79184004
121MP0005503_abnormal_tendon_morphology0.78668515
122MP0002282_abnormal_trachea_morphology0.78172820
123MP0000015_abnormal_ear_pigmentation0.76704022
124MP0002135_abnormal_kidney_morphology0.76395016
125MP0005164_abnormal_response_to0.75110255
126MP0008875_abnormal_xenobiotic_pharmacok0.74570595
127MP0006072_abnormal_retinal_apoptosis0.73725855
128MP0003866_abnormal_defecation0.72293941
129MP0005319_abnormal_enzyme/_coenzyme0.70438406
130MP0005388_respiratory_system_phenotype0.67015539
131MP0002133_abnormal_respiratory_system0.67015539
132MP0001986_abnormal_taste_sensitivity0.62172907
133MP0003632_abnormal_nervous_system0.61865086
134MP0009765_abnormal_xenobiotic_induced0.61362134
135MP0003329_amyloid_beta_deposits0.57573781
136MP0002090_abnormal_vision0.56521804
137MP0003633_abnormal_nervous_system0.55929265
138MP0002132_abnormal_respiratory_system0.52750921
139MP0005647_abnormal_sex_gland0.52501048
140MP0005253_abnormal_eye_physiology0.49038773

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.72996898
2Abnormality of liposaccharide metabolism (HP:0010968)5.72996898
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.72996898
4Stomatitis (HP:0010280)4.65295053
5Recurrent abscess formation (HP:0002722)4.17322271
6Recurrent gram-negative bacterial infections (HP:0005420)4.13347907
7Recurrent bacterial skin infections (HP:0005406)3.92672482
8Eczematoid dermatitis (HP:0000976)3.73519582
9Systemic lupus erythematosus (HP:0002725)3.54119711
10Myositis (HP:0100614)3.40008231
11Chronic mucocutaneous candidiasis (HP:0002728)3.39087896
12Recurrent cutaneous fungal infections (HP:0011370)3.39087896
13Mutism (HP:0002300)3.38367290
14Spontaneous hematomas (HP:0007420)3.36271158
15Loss of speech (HP:0002371)3.29549182
16Hematochezia (HP:0002573)3.21288200
17Vacuolated lymphocytes (HP:0001922)3.10404643
18Glomerulonephritis (HP:0000099)3.04537073
19Keratoconjunctivitis sicca (HP:0001097)3.03715513
20Complement deficiency (HP:0004431)2.97010952
21Disinhibition (HP:0000734)2.90103609
22Hemoptysis (HP:0002105)2.89009196
23Encephalitis (HP:0002383)2.86506975
24Keratoconjunctivitis (HP:0001096)2.84932326
25Elevated erythrocyte sedimentation rate (HP:0003565)2.79895568
26Pulmonary infiltrates (HP:0002113)2.79263125
27Gastrointestinal infarctions (HP:0005244)2.73009398
28Thrombocytosis (HP:0001894)2.71138159
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.69909446
30Mediastinal lymphadenopathy (HP:0100721)2.69784138
31Joint hemorrhage (HP:0005261)2.67903098
32Spinal cord lesions (HP:0100561)2.65253319
33Syringomyelia (HP:0003396)2.65253319
34Agnosia (HP:0010524)2.64870341
35Increased cerebral lipofuscin (HP:0011813)2.64726981
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.62022001
37Aortic aneurysm (HP:0004942)2.61418385
38Recurrent viral infections (HP:0004429)2.60130492
39Vasculitis (HP:0002633)2.59469364
40Orchitis (HP:0100796)2.59410582
41Short 4th metacarpal (HP:0010044)2.58577028
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58577028
43Amyloidosis (HP:0011034)2.58282082
44Autoimmune thrombocytopenia (HP:0001973)2.58226937
45Abnormality of complement system (HP:0005339)2.54963661
46Hepatosplenomegaly (HP:0001433)2.53856808
47Recurrent skin infections (HP:0001581)2.52678696
48Pustule (HP:0200039)2.44529988
49Chest pain (HP:0100749)2.42935932
50Recurrent fungal infections (HP:0002841)2.42838194
51Retinal atrophy (HP:0001105)2.41438511
52Increased IgE level (HP:0003212)2.40325039
53Impaired platelet aggregation (HP:0003540)2.35771793
54Abnormal platelet function (HP:0011869)2.35771793
55Arterial tortuosity (HP:0005116)2.34513900
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34095067
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34095067
58Abnormality of polysaccharide metabolism (HP:0011012)2.34095067
59Bicuspid aortic valve (HP:0001647)2.31214604
60Granulocytopenia (HP:0001913)2.30455743
61Abnormality of B cell number (HP:0010975)2.27601096
62B lymphocytopenia (HP:0010976)2.27601096
63Cellulitis (HP:0100658)2.27598484
64Spondylolisthesis (HP:0003302)2.26892379
65Myocardial infarction (HP:0001658)2.26139552
66Abnormality of eosinophils (HP:0001879)2.24401134
67Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.23499706
68Deep venous thrombosis (HP:0002625)2.23469248
69Abnormality of the 4th metacarpal (HP:0010012)2.21160161
70Polyneuropathy (HP:0001271)2.20889533
71Abnormality of macrophages (HP:0004311)2.20345833
72Pulmonary embolism (HP:0002204)2.19439240
73Episodic fever (HP:0001954)2.19314643
74Aortic dissection (HP:0002647)2.17179180
75Petechiae (HP:0000967)2.15997891
76Prolonged bleeding time (HP:0003010)2.13812309
77Vascular tortuosity (HP:0004948)2.13455077
78Inappropriate behavior (HP:0000719)2.12903088
79Optic neuritis (HP:0100653)2.10499056
80Retrobulbar optic neuritis (HP:0100654)2.10499056
81Mucopolysacchariduria (HP:0008155)2.10119840
82Urinary glycosaminoglycan excretion (HP:0003541)2.10119840
83Protrusio acetabuli (HP:0003179)2.09483592
84Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08892694
85Biconcave vertebral bodies (HP:0004586)2.08706335
86T lymphocytopenia (HP:0005403)2.07002366
87Gingival bleeding (HP:0000225)2.06632317
88Osteomyelitis (HP:0002754)2.05053977
89Conjunctival telangiectasia (HP:0000524)2.04538024
90Panhypogammaglobulinemia (HP:0003139)2.04237246
91Neurofibrillary tangles (HP:0002185)2.01533404
92Aplastic anemia (HP:0001915)2.00681638
93Hypoplasia of the thymus (HP:0000778)2.00141529
94Increased IgM level (HP:0003496)1.99168011
95Lymphopenia (HP:0001888)1.98652910
96Abnormality of T cell number (HP:0011839)1.97252627
97Abnormality of the pleura (HP:0002103)1.96543673
98Colon cancer (HP:0003003)1.95563060
99Neuronal loss in central nervous system (HP:0002529)1.95428948
100Recurrent pneumonia (HP:0006532)1.94713293
101Amaurosis fugax (HP:0100576)1.92713079
102Epistaxis (HP:0000421)1.92355022
103Cerebral aneurysm (HP:0004944)1.91418310
104Thoracic kyphosis (HP:0002942)1.90546646
105Diminished motivation (HP:0000745)1.90521154
106Progressive neurologic deterioration (HP:0002344)1.90453952
107Meningitis (HP:0001287)1.89995858
108Memory impairment (HP:0002354)1.88444475
109Mucosal telangiectasiae (HP:0100579)1.88392906
110Premature loss of primary teeth (HP:0006323)1.87928097
111Leukocytosis (HP:0001974)1.87616483
112IgM deficiency (HP:0002850)1.87072909
113Arterial thrombosis (HP:0004420)1.86089415
114Abnormal platelet volume (HP:0011876)1.85155550
115Stomach cancer (HP:0012126)1.85064452
116Abnormality of pyrimidine metabolism (HP:0004353)1.83752466
117Apathy (HP:0000741)1.83616966
118Anorexia (HP:0002039)1.82551803
119Acute myeloid leukemia (HP:0004808)1.82057060
120Hypercholesterolemia (HP:0003124)1.82005337
121Upper motor neuron abnormality (HP:0002127)1.81240823
122Periodontitis (HP:0000704)1.80934026
123Sepsis (HP:0100806)1.80809722
124Abnormality of the lumbar spine (HP:0100712)1.80646031
125Abnormality of the peritoneum (HP:0002585)1.80164352
126Thyroiditis (HP:0100646)1.79296238
127Chronic obstructive pulmonary disease (HP:0006510)1.79275139
128Obstructive lung disease (HP:0006536)1.79275139
129Inflammation of the large intestine (HP:0002037)1.79224571
130Combined immunodeficiency (HP:0005387)1.79045628
131Striae distensae (HP:0001065)1.78916495
132Colitis (HP:0002583)1.78322950
133Purpura (HP:0000979)1.78203303
134Hypergammaglobulinemia (HP:0010702)1.78139669
135Nephritis (HP:0000123)1.76270406
136Abnormality of the prostate (HP:0008775)1.76110144
137Renal duplication (HP:0000075)1.74622807
138Gingivitis (HP:0000230)1.73596949
139Prostate neoplasm (HP:0100787)1.73044699
140Urticaria (HP:0001025)1.70728504
141Severe combined immunodeficiency (HP:0004430)1.70343050
142Thrombophlebitis (HP:0004418)1.69898641
143Abnormality of T cells (HP:0002843)1.68932957
144Eosinophilia (HP:0001880)1.67708425
145Dysostosis multiplex (HP:0000943)1.67467627
146Increased density of long bones (HP:0006392)1.66678888
147Mitral valve prolapse (HP:0001634)1.65610031
148Soft skin (HP:0000977)1.64781956
149Basal ganglia calcification (HP:0002135)1.64555834
150Esophageal varix (HP:0002040)1.64547121
151Mesangial abnormality (HP:0001966)1.62917553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.01311662
2TGFBR23.93896461
3MAP3K102.43668500
4TGFBR12.42882308
5FES2.42518417
6CAMKK22.41540995
7NEK92.38092237
8MAP4K12.37241592
9FGR2.25431874
10KIT2.25261538
11TXK2.23262533
12KSR12.17183165
13KSR22.09933571
14GRK61.97275298
15IRAK41.95958986
16RPS6KA41.92113893
17TBK11.88956002
18ZAP701.86100033
19STK101.86038805
20PKN21.82877480
21ERN11.78523641
22TYK21.72667731
23CDK61.71566432
24BTK1.68743400
25CSF1R1.66598567
26PAK41.61990140
27TEC1.59475832
28BLK1.56733568
29MAP2K31.55985333
30CDC71.50906781
31MKNK11.48573736
32FLT31.32316385
33SRPK11.31845134
34TRIB31.30631971
35IRAK31.30619482
36SIK11.29856203
37KDR1.29355914
38CAMK1D1.26603150
39NEK21.26034984
40GRK71.24695556
41SGK21.23382263
42TIE11.23028777
43MAP3K21.22297764
44NME21.21619379
45PASK1.20528292
46YES11.19927144
47EEF2K1.15810434
48JAK31.15314912
49RAF11.15248508
50TNK21.13855069
51BMPR21.13580893
52CLK11.12517456
53ITK1.11760622
54CDK81.10643923
55ACVR1B1.10622291
56TAOK21.08960400
57EPHA31.07091719
58ERBB31.05660056
59DYRK31.03226304
60PIM11.02841625
61SCYL21.02174152
62BCKDK1.02119656
63WEE11.01757388
64MELK1.00730937
65LYN1.00111220
66IKBKB0.96559653
67SIK30.95633741
68STK40.95569750
69RIPK10.94973690
70CDK190.94255832
71MAP3K140.90023644
72CDK40.89679345
73IKBKE0.89131522
74MAP3K10.87879398
75MKNK20.87728773
76PTK60.87388277
77MAP3K130.87225910
78CHUK0.86806224
79MAPK70.86658107
80LCK0.86046076
81EPHB20.85866697
82SGK30.85413821
83BRSK20.84935282
84LRRK20.84432396
85HCK0.82875639
86CDK90.82504534
87ATR0.81221385
88CDK30.79304499
89CCNB10.79011591
90SYK0.78732157
91NLK0.76928799
92IRAK10.76899684
93BUB10.74451856
94SGK2230.73981424
95SGK4940.73981424
96EIF2AK20.73486129
97PRPF4B0.73450730
98PTK2B0.72797217
99LATS10.71312182
100JAK20.69919865
101MAP3K30.69287432
102JAK10.68851103
103FGFR40.68407778
104EPHB10.67288587
105CAMK40.66552792
106DYRK1B0.66435695
107AURKB0.66142473
108TAOK10.64591962
109STK30.63443085
110MATK0.63199703
111MAP3K110.62943787
112IGF1R0.61895202
113WNK30.61700981
114MARK30.60172106
115CAMKK10.59723494
116ERBB20.59294630
117MAP3K80.58525871
118PIM20.55518695
119ABL10.52146332
120PDGFRB0.51938903
121CDK70.51888981
122CSK0.51757212
123FYN0.51515112
124FGFR30.51499090
125NUAK10.50361455
126TLK10.50254837
127PRKCQ0.50144281
128RPS6KL10.49253428
129RPS6KC10.49253428
130RPS6KA60.48203914
131DDR20.48189062
132IRAK20.48016958
133RET0.47324347
134PAK20.47011553
135RPS6KB20.46833892
136PIK3CG0.45048056
137HIPK20.44719404
138VRK10.44661002
139MOS0.43694450
140MAP2K60.43233965
141PDK10.42635137
142TAOK30.41004058
143PLK10.40934006
144FRK0.40554525
145ADRBK20.40020041
146MAP3K70.39507029
147EGFR0.39419669
148CAMK1G0.39412157
149MARK20.36674821
150STK240.35999546
151CSNK1G20.34194507

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.02455511
2Autoimmune thyroid disease_Homo sapiens_hsa053202.36942144
3Leishmaniasis_Homo sapiens_hsa051402.16544526
4Complement and coagulation cascades_Homo sapiens_hsa046102.13397694
5DNA replication_Homo sapiens_hsa030302.12457218
6Rheumatoid arthritis_Homo sapiens_hsa053232.10964064
7Type I diabetes mellitus_Homo sapiens_hsa049402.05756365
8Pentose and glucuronate interconversions_Homo sapiens_hsa000401.87343798
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.86450901
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.82900272
11Antigen processing and presentation_Homo sapiens_hsa046121.76405373
12Legionellosis_Homo sapiens_hsa051341.74793871
13Osteoclast differentiation_Homo sapiens_hsa043801.66792204
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.60759579
15Base excision repair_Homo sapiens_hsa034101.58597989
16Chemokine signaling pathway_Homo sapiens_hsa040621.53395271
17One carbon pool by folate_Homo sapiens_hsa006701.50102098
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.47514850
19Measles_Homo sapiens_hsa051621.45468234
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44172650
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43781986
22Fatty acid degradation_Homo sapiens_hsa000711.40793783
23Other glycan degradation_Homo sapiens_hsa005111.40683786
24Mismatch repair_Homo sapiens_hsa034301.38412928
25Herpes simplex infection_Homo sapiens_hsa051681.38260248
26Primary immunodeficiency_Homo sapiens_hsa053401.36939394
27Cell cycle_Homo sapiens_hsa041101.32372800
28Collecting duct acid secretion_Homo sapiens_hsa049661.31357117
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.30664699
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.27141583
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22641472
32Pertussis_Homo sapiens_hsa051331.22536531
33Malaria_Homo sapiens_hsa051441.21436853
34PPAR signaling pathway_Homo sapiens_hsa033201.16013608
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15924242
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15542218
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13294669
38Salmonella infection_Homo sapiens_hsa051321.12649820
39Hematopoietic cell lineage_Homo sapiens_hsa046401.11150036
40Non-homologous end-joining_Homo sapiens_hsa034501.09911163
41Caffeine metabolism_Homo sapiens_hsa002321.08772898
42Chronic myeloid leukemia_Homo sapiens_hsa052201.08111396
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07406895
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06802255
45Spliceosome_Homo sapiens_hsa030401.06562808
46Acute myeloid leukemia_Homo sapiens_hsa052211.06525147
47B cell receptor signaling pathway_Homo sapiens_hsa046621.06503295
48Homologous recombination_Homo sapiens_hsa034401.06240706
49Ribosome_Homo sapiens_hsa030101.04976657
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04661456
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04277143
52Lysosome_Homo sapiens_hsa041421.02395387
53Chemical carcinogenesis_Homo sapiens_hsa052041.01692400
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99944208
55Lysine degradation_Homo sapiens_hsa003100.99907079
56Toxoplasmosis_Homo sapiens_hsa051450.98953994
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97466825
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93959000
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93624521
60Tuberculosis_Homo sapiens_hsa051520.92673471
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92667943
62Systemic lupus erythematosus_Homo sapiens_hsa053220.91826110
63Hepatitis B_Homo sapiens_hsa051610.89797855
64Apoptosis_Homo sapiens_hsa042100.89787128
65Influenza A_Homo sapiens_hsa051640.87100040
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.86367042
67Graft-versus-host disease_Homo sapiens_hsa053320.85553500
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85010192
69Notch signaling pathway_Homo sapiens_hsa043300.84877387
70Dorso-ventral axis formation_Homo sapiens_hsa043200.84683072
71HTLV-I infection_Homo sapiens_hsa051660.84229689
72Selenocompound metabolism_Homo sapiens_hsa004500.84143238
73Shigellosis_Homo sapiens_hsa051310.83126115
74Nucleotide excision repair_Homo sapiens_hsa034200.82842144
75Viral myocarditis_Homo sapiens_hsa054160.82722854
76Propanoate metabolism_Homo sapiens_hsa006400.82510919
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81606416
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.80946571
79Starch and sucrose metabolism_Homo sapiens_hsa005000.79847405
80Retinol metabolism_Homo sapiens_hsa008300.78911807
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78338071
82Peroxisome_Homo sapiens_hsa041460.77804200
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75638324
84beta-Alanine metabolism_Homo sapiens_hsa004100.75301500
85Tryptophan metabolism_Homo sapiens_hsa003800.75011097
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74795222
87Non-small cell lung cancer_Homo sapiens_hsa052230.74212976
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72545784
89TNF signaling pathway_Homo sapiens_hsa046680.71330645
90Small cell lung cancer_Homo sapiens_hsa052220.70391932
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.70369665
92Pancreatic cancer_Homo sapiens_hsa052120.65160034
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64628414
94Pyrimidine metabolism_Homo sapiens_hsa002400.64514056
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64402574
96Hepatitis C_Homo sapiens_hsa051600.64298583
97p53 signaling pathway_Homo sapiens_hsa041150.64218841
98Thyroid cancer_Homo sapiens_hsa052160.64101899
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63760622
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.63430533
101Viral carcinogenesis_Homo sapiens_hsa052030.63058762
102Prolactin signaling pathway_Homo sapiens_hsa049170.62397300
103Platelet activation_Homo sapiens_hsa046110.61437215
104Fatty acid metabolism_Homo sapiens_hsa012120.61292792
105Protein export_Homo sapiens_hsa030600.61191110
106African trypanosomiasis_Homo sapiens_hsa051430.60910217
107T cell receptor signaling pathway_Homo sapiens_hsa046600.60493813
108Amoebiasis_Homo sapiens_hsa051460.59860909
109MicroRNAs in cancer_Homo sapiens_hsa052060.58949377
110Phagosome_Homo sapiens_hsa041450.58763885
111Allograft rejection_Homo sapiens_hsa053300.58082605
112Regulation of autophagy_Homo sapiens_hsa041400.55900066
113Colorectal cancer_Homo sapiens_hsa052100.55130871
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54491155
115Basal cell carcinoma_Homo sapiens_hsa052170.54246994
116Adherens junction_Homo sapiens_hsa045200.53586073
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52394261
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.50748543
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50528133
120Asthma_Homo sapiens_hsa053100.50018356
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49278707
122TGF-beta signaling pathway_Homo sapiens_hsa043500.48649214
123Epstein-Barr virus infection_Homo sapiens_hsa051690.47912687
124Vibrio cholerae infection_Homo sapiens_hsa051100.47672783
125Folate biosynthesis_Homo sapiens_hsa007900.47437316
126Endocytosis_Homo sapiens_hsa041440.45623223
127HIF-1 signaling pathway_Homo sapiens_hsa040660.44960345
128Type II diabetes mellitus_Homo sapiens_hsa049300.40726705
129GnRH signaling pathway_Homo sapiens_hsa049120.39616454
130Renin secretion_Homo sapiens_hsa049240.39318220
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36468580
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.36277186
133Renal cell carcinoma_Homo sapiens_hsa052110.35730495
134VEGF signaling pathway_Homo sapiens_hsa043700.31368701
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30100836
136mTOR signaling pathway_Homo sapiens_hsa041500.29801597
137Endometrial cancer_Homo sapiens_hsa052130.29793759
138FoxO signaling pathway_Homo sapiens_hsa040680.28622638
139Estrogen signaling pathway_Homo sapiens_hsa049150.28385751
140Prostate cancer_Homo sapiens_hsa052150.23454265
141Long-term depression_Homo sapiens_hsa047300.22307758
142Rap1 signaling pathway_Homo sapiens_hsa040150.22213547
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21962696
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17665528
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16386893

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