RCC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomarker for colorectal cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.52436800
2establishment of integrated proviral latency (GO:0075713)4.57274807
3nuclear pore organization (GO:0006999)4.51323325
4nuclear pore complex assembly (GO:0051292)4.46632674
5folic acid-containing compound biosynthetic process (GO:0009396)4.31280665
6regulation of translational fidelity (GO:0006450)4.11953548
7mitotic nuclear envelope disassembly (GO:0007077)4.11492884
8DNA strand elongation involved in DNA replication (GO:0006271)3.97807486
9heterochromatin organization (GO:0070828)3.95751815
10viral transcription (GO:0019083)3.94429026
11DNA replication initiation (GO:0006270)3.93873481
12negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.92956378
13regulation of histone H3-K9 methylation (GO:0051570)3.89232528
14pre-miRNA processing (GO:0031054)3.88260756
15DNA duplex unwinding (GO:0032508)3.87750870
16translational termination (GO:0006415)3.85923689
17nuclear envelope disassembly (GO:0051081)3.84959435
18membrane disassembly (GO:0030397)3.84959435
19DNA geometric change (GO:0032392)3.84640855
20IMP biosynthetic process (GO:0006188)3.80551439
21DNA replication-dependent nucleosome assembly (GO:0006335)3.78242092
22DNA replication-dependent nucleosome organization (GO:0034723)3.78242092
23negative regulation of histone methylation (GO:0031061)3.77230288
24DNA strand elongation (GO:0022616)3.76869825
25ribosomal small subunit assembly (GO:0000028)3.75243751
26* protein localization to kinetochore (GO:0034501)3.74811182
27formation of translation preinitiation complex (GO:0001731)3.73876657
28negative regulation of RNA splicing (GO:0033119)3.70962314
29sister chromatid segregation (GO:0000819)3.68189163
30mitotic sister chromatid segregation (GO:0000070)3.68106868
31* protein complex localization (GO:0031503)3.64468598
32maturation of SSU-rRNA (GO:0030490)3.61071536
33dosage compensation (GO:0007549)3.58586639
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.57486422
35translational elongation (GO:0006414)3.51875900
36regulation of gene silencing by RNA (GO:0060966)3.46971574
37regulation of posttranscriptional gene silencing (GO:0060147)3.46971574
38regulation of gene silencing by miRNA (GO:0060964)3.46971574
39translational initiation (GO:0006413)3.45691523
40chromatin assembly (GO:0031497)3.45331672
41mitotic chromosome condensation (GO:0007076)3.44144072
42negative regulation of mRNA processing (GO:0050686)3.42238503
43regulation of translational termination (GO:0006449)3.41370474
44telomere maintenance via semi-conservative replication (GO:0032201)3.40370318
45L-serine metabolic process (GO:0006563)3.37429534
46histone arginine methylation (GO:0034969)3.37387738
47pore complex assembly (GO:0046931)3.36400457
48establishment of viral latency (GO:0019043)3.32747786
49IMP metabolic process (GO:0046040)3.31544675
50mitotic sister chromatid cohesion (GO:0007064)3.27961554
51nucleobase biosynthetic process (GO:0046112)3.26996195
52negative regulation of mRNA metabolic process (GO:1903312)3.24048884
53peptidyl-arginine omega-N-methylation (GO:0035247)3.22424805
54chromosome condensation (GO:0030261)3.21775350
55mRNA stabilization (GO:0048255)3.21673722
56RNA stabilization (GO:0043489)3.21673722
57paraxial mesoderm development (GO:0048339)3.17763058
58ribosomal small subunit biogenesis (GO:0042274)3.17265842
59positive regulation of SMAD protein import into nucleus (GO:0060391)3.16122982
60ATP-dependent chromatin remodeling (GO:0043044)3.14516997
61* protein localization to chromosome, centromeric region (GO:0071459)3.13672236
62regulation of sister chromatid cohesion (GO:0007063)3.11458153
63nuclear envelope organization (GO:0006998)3.10920588
643-UTR-mediated mRNA stabilization (GO:0070935)3.08300459
65spliceosomal tri-snRNP complex assembly (GO:0000244)3.07304646
66cellular protein complex disassembly (GO:0043624)3.04846692
67DNA synthesis involved in DNA repair (GO:0000731)3.04624874
68protein complex disassembly (GO:0043241)3.03567700
69regulation of nucleobase-containing compound transport (GO:0032239)3.03215288
70DNA conformation change (GO:0071103)3.02818677
71chromatin assembly or disassembly (GO:0006333)3.02814547
72mitotic metaphase plate congression (GO:0007080)3.02532786
73mitotic recombination (GO:0006312)3.01581456
74protein export from nucleus (GO:0006611)3.00978333
75translesion synthesis (GO:0019985)3.00793634
76regulation of RNA export from nucleus (GO:0046831)3.00247610
77proline biosynthetic process (GO:0006561)2.98862839
78mRNA splicing, via spliceosome (GO:0000398)2.98710656
79RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.98710656
80DNA replication checkpoint (GO:0000076)2.97775126
81viral life cycle (GO:0019058)2.97178206
82regulation of spindle organization (GO:0090224)2.96784161
83RNA splicing, via transesterification reactions (GO:0000375)2.96506053
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96098952
85telomere maintenance via recombination (GO:0000722)2.95073115
86regulation of mRNA stability (GO:0043488)2.94147229
87alternative mRNA splicing, via spliceosome (GO:0000380)2.92612271
88planar cell polarity pathway involved in neural tube closure (GO:0090179)2.92386876
89ribosomal large subunit biogenesis (GO:0042273)2.91339615
90protein targeting to ER (GO:0045047)2.87825107
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.85843691
92cotranslational protein targeting to membrane (GO:0006613)2.85403322
93nuclear-transcribed mRNA catabolic process (GO:0000956)2.84884370
94non-recombinational repair (GO:0000726)2.84831671
95double-strand break repair via nonhomologous end joining (GO:0006303)2.84831671
96mitotic G1 DNA damage checkpoint (GO:0031571)2.81994563
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81917262
98DNA topological change (GO:0006265)2.81571661
99peptidyl-arginine methylation (GO:0018216)2.81551763
100peptidyl-arginine N-methylation (GO:0035246)2.81551763
101histone H2A monoubiquitination (GO:0035518)2.81204423
102telomere maintenance via telomere lengthening (GO:0010833)2.80930801
103ribonucleoprotein complex biogenesis (GO:0022613)2.80875296
104negative regulation of DNA repair (GO:0045738)2.80574623
105regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80243829
106protein-DNA complex disassembly (GO:0032986)2.79704346
107nucleosome disassembly (GO:0006337)2.79704346
108ribosome assembly (GO:0042255)2.79703240
109DNA replication-independent nucleosome organization (GO:0034724)2.79520074
110DNA replication-independent nucleosome assembly (GO:0006336)2.79520074
111macromolecular complex disassembly (GO:0032984)2.79091771
112regulation of gene silencing (GO:0060968)2.78855913
113purine nucleobase biosynthetic process (GO:0009113)2.76776876
114termination of RNA polymerase II transcription (GO:0006369)2.76270446
115RNA catabolic process (GO:0006401)2.76025535
116mRNA transport (GO:0051028)2.75769985
117nucleotide-excision repair, DNA gap filling (GO:0006297)2.75085356
118establishment of protein localization to endoplasmic reticulum (GO:0072599)2.74709627
119negative regulation of chromosome segregation (GO:0051985)2.73967449
120regulation of RNA stability (GO:0043487)2.73787470
121somatic diversification of immune receptors via somatic mutation (GO:0002566)2.73750590
122somatic hypermutation of immunoglobulin genes (GO:0016446)2.73750590
123V(D)J recombination (GO:0033151)2.72648952
124rRNA transcription (GO:0009303)2.72387653
125mRNA catabolic process (GO:0006402)2.71606321
126ribosome biogenesis (GO:0042254)2.71293741
127metaphase plate congression (GO:0051310)2.71133220
128regulation of stem cell maintenance (GO:2000036)2.71085937
129viral mRNA export from host cell nucleus (GO:0046784)2.70336671
130regulation of DNA damage checkpoint (GO:2000001)2.69398810
131DNA packaging (GO:0006323)2.67960038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.15959133
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.80284211
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.67798081
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46485388
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37353201
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.28601987
7MYC_22102868_ChIP-Seq_BL_Human3.11555541
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96743267
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88151573
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36114117
11XRN2_22483619_ChIP-Seq_HELA_Human2.11686923
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10579268
13E2F1_21310950_ChIP-Seq_MCF-7_Human1.98148261
14* VDR_21846776_ChIP-Seq_THP-1_Human1.98020684
15NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93743838
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93272378
17CIITA_25753668_ChIP-Seq_RAJI_Human1.90380086
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83151506
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.83018542
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81491414
21AR_21909140_ChIP-Seq_LNCAP_Human1.81395212
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.71872597
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68058817
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.67392048
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64564451
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61371719
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58407224
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58075401
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55205339
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53823431
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.53007581
32KDM5A_27292631_Chip-Seq_BREAST_Human1.49651658
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47874912
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46688578
35TTF2_22483619_ChIP-Seq_HELA_Human1.46545097
36FOXP3_21729870_ChIP-Seq_TREG_Human1.43737980
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42409173
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42217875
39VDR_23849224_ChIP-Seq_CD4+_Human1.41550041
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.40807127
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39420029
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39394469
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37966606
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37569150
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37452048
46* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33098049
47KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32577876
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31810425
49* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29967136
50GABP_19822575_ChIP-Seq_HepG2_Human1.29296325
51DCP1A_22483619_ChIP-Seq_HELA_Human1.24807751
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24004122
53* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23830901
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21588155
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20897940
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20323825
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20323825
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20323825
59* UTX_26944678_Chip-Seq_JUKART_Human1.20174143
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19835625
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19793289
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18913520
63TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17933561
64* KDM2B_26808549_Chip-Seq_DND41_Human1.17500155
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.17378130
66* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17306671
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.15412399
68TFEB_21752829_ChIP-Seq_HELA_Human1.15001958
69CLOCK_20551151_ChIP-Seq_293T_Human1.14891994
70* MAF_26560356_Chip-Seq_TH1_Human1.13526421
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.12564070
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11650782
73* RACK7_27058665_Chip-Seq_MCF-7_Human1.11466851
74* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10655634
75ZNF263_19887448_ChIP-Seq_K562_Human1.10445106
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10316582
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09918580
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.09526181
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09190076
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08035502
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07413655
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04401080
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04221268
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03850420
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03817007
86KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03607663
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03413745
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03397644
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02528753
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02420468
91* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02318333
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02163922
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01704549
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.99560105
95* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99058086
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99038588
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97334519
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96879905
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96238706
100* CHD1_26751641_Chip-Seq_LNCaP_Human0.94968453
101* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94899529
102ELK1_19687146_ChIP-ChIP_HELA_Human0.92144269
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92067680
104* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91473274
105* NCOR1_26117541_ChIP-Seq_K562_Human0.91346498
106SCL_19346495_ChIP-Seq_HPC-7_Human0.91279544
107* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91085563
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90990658
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90847546
110KAP1_27257070_Chip-Seq_ESCs_Mouse0.90814817
111ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90198397
112* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89803395
113LXR_22292898_ChIP-Seq_THP-1_Human0.89699181
114* MYB_26560356_Chip-Seq_TH1_Human0.89538238
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89476759
116* ATF3_27146783_Chip-Seq_COLON_Human0.89473832
117NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89006641
118MYB_26560356_Chip-Seq_TH2_Human0.88697236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.81296565
2MP0010094_abnormal_chromosome_stability3.76714206
3MP0003693_abnormal_embryo_hatching3.73432606
4MP0004957_abnormal_blastocyst_morpholog3.56958370
5MP0003077_abnormal_cell_cycle3.29777799
6MP0010352_gastrointestinal_tract_polyps3.17816769
7MP0008057_abnormal_DNA_replication3.17490692
8MP0002396_abnormal_hematopoietic_system2.48828658
9MP0005076_abnormal_cell_differentiation2.42602329
10MP0001730_embryonic_growth_arrest2.41142116
11MP0003705_abnormal_hypodermis_morpholog2.37252366
12MP0002254_reproductive_system_inflammat2.32526034
13MP0000350_abnormal_cell_proliferation2.32136185
14MP0003941_abnormal_skin_development2.31598121
15MP0010307_abnormal_tumor_latency2.22722325
16MP0008007_abnormal_cellular_replicative2.22108408
17MP0003123_paternal_imprinting2.18404291
18MP0002796_impaired_skin_barrier2.04303965
19MP0009278_abnormal_bone_marrow1.97115193
20MP0004808_abnormal_hematopoietic_stem1.97016628
21MP0008058_abnormal_DNA_repair1.96413720
22MP0008932_abnormal_embryonic_tissue1.90945466
23MP0004197_abnormal_fetal_growth/weight/1.86932230
24MP0005380_embryogenesis_phenotype1.85485633
25MP0001672_abnormal_embryogenesis/_devel1.85485633
26MP0002084_abnormal_developmental_patter1.83304837
27MP0001697_abnormal_embryo_size1.79756754
28MP0002085_abnormal_embryonic_tissue1.78763503
29MP0000490_abnormal_crypts_of1.76319627
30MP0003984_embryonic_growth_retardation1.72007283
31MP0002088_abnormal_embryonic_growth/wei1.69335447
32MP0002086_abnormal_extraembryonic_tissu1.67472239
33MP0002080_prenatal_lethality1.65725281
34MP0010030_abnormal_orbit_morphology1.64583765
35MP0000537_abnormal_urethra_morphology1.62413952
36MP0001849_ear_inflammation1.52449185
37MP0010234_abnormal_vibrissa_follicle1.42743612
38MP0000703_abnormal_thymus_morphology1.42308039
39MP0005397_hematopoietic_system_phenotyp1.41024892
40MP0001545_abnormal_hematopoietic_system1.41024892
41MP0002019_abnormal_tumor_incidence1.39279113
42MP0000566_synostosis1.38124575
43MP0009053_abnormal_anal_canal1.37255297
44MP0003567_abnormal_fetal_cardiomyocyte1.37066858
45MP0002009_preneoplasia1.36038760
46MP0008877_abnormal_DNA_methylation1.35573031
47MP0003121_genomic_imprinting1.34806342
48MP0002877_abnormal_melanocyte_morpholog1.34420779
49MP0000313_abnormal_cell_death1.33583066
50MP0003566_abnormal_cell_adhesion1.32641164
51MP0000579_abnormal_nail_morphology1.30867508
52MP0003786_premature_aging1.27788214
53MP0001293_anophthalmia1.23236776
54MP0006054_spinal_hemorrhage1.21645651
55MP0002398_abnormal_bone_marrow1.21528801
56MP0003763_abnormal_thymus_physiology1.21169204
57MP0002653_abnormal_ependyma_morphology1.19612043
58MP0000733_abnormal_muscle_development1.19157435
59MP0003890_abnormal_embryonic-extraembry1.16145637
60MP0002722_abnormal_immune_system1.10651918
61MP0003315_abnormal_perineum_morphology1.09223821
62MP0000678_abnormal_parathyroid_gland1.09190902
63MP0003119_abnormal_digestive_system1.07176874
64MP0001915_intracranial_hemorrhage1.07123507
65MP0000428_abnormal_craniofacial_morphol1.05882052
66MP0005023_abnormal_wound_healing1.05689103
67MP0003300_gastrointestinal_ulcer1.04697417
68MP0009333_abnormal_splenocyte_physiolog1.04127706
69MP0009672_abnormal_birth_weight1.00975502
70MP0003718_maternal_effect0.99956133
71MP0000689_abnormal_spleen_morphology0.99589325
72MP0005451_abnormal_body_composition0.99552394
73MP0001346_abnormal_lacrimal_gland0.98164747
74MP0009703_decreased_birth_body0.97443537
75MP0002092_abnormal_eye_morphology0.96060587
76MP0002111_abnormal_tail_morphology0.94851936
77MP0003303_peritoneal_inflammation0.94023232
78MP0002089_abnormal_postnatal_growth/wei0.89204053
79MP0008770_decreased_survivor_rate0.86443984
80MP0000477_abnormal_intestine_morphology0.86161425
81MP0003115_abnormal_respiratory_system0.85935786
82MP0002925_abnormal_cardiovascular_devel0.85924947
83MP0001216_abnormal_epidermal_layer0.85826689
84MP0000858_altered_metastatic_potential0.83503613
85MP0002429_abnormal_blood_cell0.83492068
86MP0002697_abnormal_eye_size0.83393538
87MP0002060_abnormal_skin_morphology0.82908046
88MP0001661_extended_life_span0.81270498
89MP0005501_abnormal_skin_physiology0.81024125
90MP0002098_abnormal_vibrissa_morphology0.80697420
91MP0009697_abnormal_copulation0.79811121
92MP0003935_abnormal_craniofacial_develop0.78131697
93MP0000685_abnormal_immune_system0.77631550
94MP0005621_abnormal_cell_physiology0.77594632
95MP0004858_abnormal_nervous_system0.77218845
96MP0000432_abnormal_head_morphology0.76174519
97MP0003937_abnormal_limbs/digits/tail_de0.75903689
98MP0010630_abnormal_cardiac_muscle0.74960637
99MP0005257_abnormal_intraocular_pressure0.74850130
100MP0000716_abnormal_immune_system0.74110001
101MP0000762_abnormal_tongue_morphology0.74010784
102MP0004185_abnormal_adipocyte_glucose0.73324193
103MP0008260_abnormal_autophagy0.72900753
104MP0005384_cellular_phenotype0.72832991
105MP0002210_abnormal_sex_determination0.72789451
106MP0001145_abnormal_male_reproductive0.71458164
107MP0003942_abnormal_urinary_system0.71111721
108MP0000627_abnormal_mammary_gland0.70237038
109MP0005666_abnormal_adipose_tissue0.70017926
110MP0009931_abnormal_skin_appearance0.69634438
111MP0003861_abnormal_nervous_system0.69590051
112MP0004272_abnormal_basement_membrane0.68988457
113MP0001800_abnormal_humoral_immune0.68980959
114MP0009379_abnormal_foot_pigmentation0.68924896
115MP0001286_abnormal_eye_development0.68138405
116MP0000465_gastrointestinal_hemorrhage0.67710571
117MP0000371_diluted_coat_color0.67700931
118MP0000377_abnormal_hair_follicle0.67511626
119MP0000358_abnormal_cell_content/0.67246065
120MP0002075_abnormal_coat/hair_pigmentati0.67243311
121MP0002932_abnormal_joint_morphology0.67239394
122MP0002249_abnormal_larynx_morphology0.66420577
123MP0003385_abnormal_body_wall0.66418925
124MP0003453_abnormal_keratinocyte_physiol0.66205034
125MP0004782_abnormal_surfactant_physiolog0.65889793
126MP0004264_abnormal_extraembryonic_tissu0.63835827
127MP0004133_heterotaxia0.60310947
128MP0001784_abnormal_fluid_regulation0.59596290
129MP0004233_abnormal_muscle_weight0.59431715
130MP0002405_respiratory_system_inflammati0.58247975
131MP0001348_abnormal_lacrimal_gland0.57116506
132MP0005623_abnormal_meninges_morphology0.57089333

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.86485815
2Selective tooth agenesis (HP:0001592)3.32463203
3Reticulocytopenia (HP:0001896)3.25312394
4Medulloblastoma (HP:0002885)3.09252151
5Basal cell carcinoma (HP:0002671)2.93858521
6Colon cancer (HP:0003003)2.90072180
7Hyperacusis (HP:0010780)2.88356725
8Abnormality of cells of the erythroid lineage (HP:0012130)2.87895472
9Abnormality of the astrocytes (HP:0100707)2.83712337
10Astrocytoma (HP:0009592)2.83712337
11Short 4th metacarpal (HP:0010044)2.82916124
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.82916124
13Multiple enchondromatosis (HP:0005701)2.80277972
14Increased nuchal translucency (HP:0010880)2.77820452
15Nephroblastoma (Wilms tumor) (HP:0002667)2.67087897
16Proximal placement of thumb (HP:0009623)2.61773536
17Cortical dysplasia (HP:0002539)2.61596270
18Abnormal number of erythroid precursors (HP:0012131)2.59693074
19Rhabdomyosarcoma (HP:0002859)2.57736569
20Deviation of the thumb (HP:0009603)2.57399625
21Spastic diplegia (HP:0001264)2.56982931
22High anterior hairline (HP:0009890)2.55564665
23Ankyloglossia (HP:0010296)2.55297174
24Abnormality of the salivary glands (HP:0010286)2.50000004
25Abnormal number of incisors (HP:0011064)2.48290822
26Neoplasm of striated muscle (HP:0009728)2.46275312
27Neoplasm of the oral cavity (HP:0100649)2.45578841
28Embryonal renal neoplasm (HP:0011794)2.43219034
29Progressive external ophthalmoplegia (HP:0000590)2.43100979
30Progressive muscle weakness (HP:0003323)2.42544612
31Patellar aplasia (HP:0006443)2.32691387
32Dysmetric saccades (HP:0000641)2.32448435
33Missing ribs (HP:0000921)2.31164092
34Insomnia (HP:0100785)2.31006912
35Volvulus (HP:0002580)2.29356322
36Renal duplication (HP:0000075)2.29353507
37Chromsome breakage (HP:0040012)2.25470419
38Glioma (HP:0009733)2.24139886
39Abnormality of the fingertips (HP:0001211)2.22639087
40Aplasia/Hypoplasia of the patella (HP:0006498)2.19659015
41High pitched voice (HP:0001620)2.19482951
42Atresia of the external auditory canal (HP:0000413)2.16867949
43Urethral obstruction (HP:0000796)2.16714290
44Prominent nose (HP:0000448)2.15681674
45Skin tags (HP:0010609)2.12776504
46Agnosia (HP:0010524)2.12743342
47Abnormality of the 4th metacarpal (HP:0010012)2.12699121
48Birth length less than 3rd percentile (HP:0003561)2.11913931
49Increased density of long bones (HP:0006392)2.10281928
50Abnormality of oral frenula (HP:0000190)2.10160636
51Leiomyosarcoma (HP:0100243)2.09727904
52Uterine leiomyosarcoma (HP:0002891)2.09727904
53Gastrointestinal carcinoma (HP:0002672)2.08908564
54Malignant gastrointestinal tract tumors (HP:0006749)2.08908564
55Cutaneous melanoma (HP:0012056)2.06255163
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06208830
57Long eyelashes (HP:0000527)2.05875272
58Overlapping toe (HP:0001845)2.05123924
59Asymmetry of the thorax (HP:0001555)2.04831881
60Angiofibromas (HP:0010615)2.04498656
61Adenoma sebaceum (HP:0009720)2.04498656
62Long palpebral fissure (HP:0000637)2.03985635
63Squamous cell carcinoma (HP:0002860)2.03093008
64Absent thumb (HP:0009777)2.02989943
65Duplication of thumb phalanx (HP:0009942)2.01499936
66Abnormality of the labia minora (HP:0012880)2.01495520
67Deep philtrum (HP:0002002)2.01435616
68Pseudobulbar signs (HP:0002200)2.00925686
69Myelodysplasia (HP:0002863)2.00158335
70Acute lymphatic leukemia (HP:0006721)1.99731646
71Microvesicular hepatic steatosis (HP:0001414)1.99711570
72Cafe-au-lait spot (HP:0000957)1.97667752
73Abnormality of the anterior horn cell (HP:0006802)1.97417451
74Degeneration of anterior horn cells (HP:0002398)1.97417451
75Abnormality of the preputium (HP:0100587)1.97387396
76Neoplasm of the pancreas (HP:0002894)1.96255020
77Abnormality of cochlea (HP:0000375)1.95363156
78Septate vagina (HP:0001153)1.95269754
79Ulnar bowing (HP:0003031)1.94176834
80Supernumerary ribs (HP:0005815)1.93160716
81Preauricular skin tag (HP:0000384)1.93025982
82Amaurosis fugax (HP:0100576)1.92052918
83Biliary tract neoplasm (HP:0100574)1.92041372
84Disproportionate tall stature (HP:0001519)1.91929748
85Trismus (HP:0000211)1.90448836
86Broad distal phalanx of finger (HP:0009836)1.90283108
87Abnormality of the distal phalanx of the thumb (HP:0009617)1.90193729
88Rib fusion (HP:0000902)1.89418981
89Abnormality of chromosome stability (HP:0003220)1.89386691
90Ectopic kidney (HP:0000086)1.89242309
91Thrombocytosis (HP:0001894)1.89102147
92Choanal stenosis (HP:0000452)1.88349368
93Supernumerary bones of the axial skeleton (HP:0009144)1.87645649
94Bowel diverticulosis (HP:0005222)1.87121133
95Facial cleft (HP:0002006)1.87112968
96Pallor (HP:0000980)1.87024051
97Broad palm (HP:0001169)1.87004910
98Esophageal atresia (HP:0002032)1.86217485
9911 pairs of ribs (HP:0000878)1.85990069
100Cellulitis (HP:0100658)1.85386508
101Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83968761
102Abnormality of homocysteine metabolism (HP:0010919)1.82104756
103Homocystinuria (HP:0002156)1.82104756
104Arnold-Chiari malformation (HP:0002308)1.80528643
105Abnormality of the calcaneus (HP:0008364)1.80429048
106Renovascular hypertension (HP:0100817)1.80185370
107Facial hemangioma (HP:0000329)1.79006638
108Abnormal lung lobation (HP:0002101)1.76915562
109Choanal atresia (HP:0000453)1.76684571
110Oral leukoplakia (HP:0002745)1.76360241
111Overriding aorta (HP:0002623)1.76163965
112Embryonal neoplasm (HP:0002898)1.75921895
113Absent radius (HP:0003974)1.75676053
114Anal stenosis (HP:0002025)1.75115701
115Genu recurvatum (HP:0002816)1.75110818
116Meckel diverticulum (HP:0002245)1.75082862
117Breast hypoplasia (HP:0003187)1.74754028
118Turricephaly (HP:0000262)1.74728414
119Cutis marmorata (HP:0000965)1.74310486
120Abnormality of reticulocytes (HP:0004312)1.74222894
121Tracheoesophageal fistula (HP:0002575)1.73449043
122Abnormality of the lacrimal duct (HP:0011481)1.72945556
123Fibroma (HP:0010614)1.71901222
124Fibrous tissue neoplasm (HP:0012316)1.71817953
125Transitional cell carcinoma of the bladder (HP:0006740)1.70664448
126Macrocytic anemia (HP:0001972)1.70175583
127Abnormality of the ileum (HP:0001549)1.69954345
128Metaphyseal cupping (HP:0003021)1.68295625
129Horseshoe kidney (HP:0000085)1.67970433
130Elfin facies (HP:0004428)1.67887841
131Shallow orbits (HP:0000586)1.67464619
132Syringomyelia (HP:0003396)1.67356074
133Spinal cord lesions (HP:0100561)1.67356074
134Impulsivity (HP:0100710)1.67082696
135Broad thumb (HP:0011304)1.66818278
136Deep palmar crease (HP:0006191)1.66810806
137Hepatoblastoma (HP:0002884)1.66786261
138Pointed chin (HP:0000307)1.65710405
139Abnormality of the carotid arteries (HP:0005344)1.65676924
140Trigonocephaly (HP:0000243)1.65537569
141Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65476729
142Papilloma (HP:0012740)1.64939680
143Verrucae (HP:0200043)1.64939680
144Heterotopia (HP:0002282)1.64608943
145Skull defect (HP:0001362)1.64555933
146Obsessive-compulsive behavior (HP:0000722)1.63821952
147Absent forearm bone (HP:0003953)1.63498607
148Aplasia involving forearm bones (HP:0009822)1.63498607
149Rectal prolapse (HP:0002035)1.63089322
150Aplasia/Hypoplasia of the uvula (HP:0010293)1.62449362
151Patellar dislocation (HP:0002999)1.62265087
152Sandal gap (HP:0001852)1.61969844
153Protrusio acetabuli (HP:0003179)1.61447756
154Uterine neoplasm (HP:0010784)1.60511272
155Short middle phalanx of the 5th finger (HP:0004220)1.60507493
156Acute myeloid leukemia (HP:0004808)1.59814188
157Flared metaphyses (HP:0003015)1.59331302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.81670460
2SMG14.29686357
3MAP3K103.73603557
4CDC73.63098578
5CDK123.52045867
6PKN23.03773121
7TRIB32.69911348
8NEK22.66512108
9WEE12.59595632
10RPS6KB22.36548753
11BUB12.29303852
12VRK22.01380751
13TSSK61.92080682
14PRPF4B1.91375040
15TAF11.87972194
16TTK1.87301228
17CDK41.80966221
18PASK1.80344643
19STK101.67952013
20MAP4K11.67601591
21ALK1.62302635
22CDK71.61587054
23PBK1.52307333
24SCYL21.51426960
25BRD41.45178064
26MAP3K81.44893817
27ATR1.40271307
28LRRK21.39406244
29PAK41.39117315
30NEK11.38144184
31SRPK11.34562621
32MKNK11.34283209
33EPHA21.31632076
34ICK1.30129828
35FGFR41.30027161
36CDK61.28433423
37PLK11.25233670
38TESK21.21367840
39CHEK11.21243614
40IRAK31.19572418
41GRK61.18792749
42AURKB1.17926093
43PLK41.15222700
44MTOR1.14978411
45PTK61.14971313
46TGFBR11.14248277
47RPS6KA41.12631651
48FLT31.10282865
49TLK11.09906113
50CAMK1D1.08113905
51DYRK31.07023088
52STK41.07016575
53PIM11.04210436
54MKNK21.01727103
55CHEK21.00527599
56SIK10.96565693
57CAMK1G0.93994264
58BMX0.93273883
59NME20.93000764
60STK30.92616799
61CDK20.91852158
62MAP3K90.90339908
63ATM0.83001130
64PAK20.81812769
65PLK30.79826880
66CLK10.79492582
67MAPKAPK30.76915240
68EIF2AK10.75942104
69BRSK20.74972705
70AURKA0.73609144
71BTK0.73411529
72STK240.73385328
73PDGFRA0.72019773
74MAP3K130.65974281
75TTN0.65863336
76BRAF0.65752034
77KSR20.63562018
78MAP2K30.63422531
79ERN10.63231572
80ACVR1B0.61096332
81CDK10.59160468
82AKT20.57964176
83ZAP700.54539961
84MELK0.53928412
85PAK10.53516100
86CDK90.53097188
87NME10.52866637
88LATS10.52397544
89CSNK2A20.51562162
90TAOK20.51442150
91BRSK10.50624412
92FGFR10.49776756
93ILK0.48623765
94EIF2AK20.48176614
95VRK10.48045980
96RPS6KA10.47326675
97CDK80.46757219
98CSF1R0.46731476
99RIPK10.46694100
100JAK30.46399114
101MAP3K110.46081367
102CSNK1E0.45745286
103DMPK0.45637935
104CSNK1D0.45225594
105TYRO30.42443708
106PTK20.41567361
107PRKDC0.40715931
108PNCK0.40277044
109RPS6KC10.40229891
110RPS6KL10.40229891
111SIK20.39729836
112MAPK140.39326880
113LATS20.39124173
114ZAK0.38956981
115ERBB40.37919740
116RPS6KA60.36349713
117CHUK0.36313343
118MAPK110.35909425
119CDK11A0.34809690
120YES10.33672364
121MAPK10.33623202
122GSK3B0.33600402
123MST1R0.33533476
124PRKCI0.33524035
125TAOK10.33520592
126MAPKAPK20.33370877
127AKT10.32019971
128KDR0.31779779
129MAP2K20.31605960

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.23799891
2Mismatch repair_Homo sapiens_hsa034303.53893109
3Spliceosome_Homo sapiens_hsa030403.18733019
4RNA transport_Homo sapiens_hsa030132.95277835
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83199516
6One carbon pool by folate_Homo sapiens_hsa006702.81970222
7Ribosome_Homo sapiens_hsa030102.69521335
8Base excision repair_Homo sapiens_hsa034102.67340589
9Cell cycle_Homo sapiens_hsa041102.65348467
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40458394
11Nucleotide excision repair_Homo sapiens_hsa034202.21636576
12mRNA surveillance pathway_Homo sapiens_hsa030152.21503611
13Homologous recombination_Homo sapiens_hsa034402.09470326
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.84550548
15Non-homologous end-joining_Homo sapiens_hsa034501.73058493
16Fanconi anemia pathway_Homo sapiens_hsa034601.61251317
17RNA polymerase_Homo sapiens_hsa030201.58486744
18p53 signaling pathway_Homo sapiens_hsa041151.51595651
19Chronic myeloid leukemia_Homo sapiens_hsa052201.49598395
20RNA degradation_Homo sapiens_hsa030181.47946968
21Viral carcinogenesis_Homo sapiens_hsa052031.42107714
22Pyrimidine metabolism_Homo sapiens_hsa002401.34880816
23MicroRNAs in cancer_Homo sapiens_hsa052061.33856278
24HTLV-I infection_Homo sapiens_hsa051661.25585116
25Antigen processing and presentation_Homo sapiens_hsa046121.24450945
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22261770
27Systemic lupus erythematosus_Homo sapiens_hsa053221.20804383
28Small cell lung cancer_Homo sapiens_hsa052221.20052400
29Thyroid cancer_Homo sapiens_hsa052161.18636314
30Epstein-Barr virus infection_Homo sapiens_hsa051691.17841091
31Notch signaling pathway_Homo sapiens_hsa043301.16062172
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15160378
33Colorectal cancer_Homo sapiens_hsa052101.14707393
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13145755
35Primary immunodeficiency_Homo sapiens_hsa053401.10968821
36Acute myeloid leukemia_Homo sapiens_hsa052211.09764602
37Basal cell carcinoma_Homo sapiens_hsa052171.08952689
38Herpes simplex infection_Homo sapiens_hsa051681.07814880
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07031098
40Non-small cell lung cancer_Homo sapiens_hsa052231.04924335
41Basal transcription factors_Homo sapiens_hsa030221.03196659
42mTOR signaling pathway_Homo sapiens_hsa041501.01514104
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98957027
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.98849557
45B cell receptor signaling pathway_Homo sapiens_hsa046620.97600219
46Carbon metabolism_Homo sapiens_hsa012000.96308180
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.94997034
48Hippo signaling pathway_Homo sapiens_hsa043900.94472672
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93937694
50Oocyte meiosis_Homo sapiens_hsa041140.91159385
51Bladder cancer_Homo sapiens_hsa052190.91088202
52Proteasome_Homo sapiens_hsa030500.89762301
53Vitamin B6 metabolism_Homo sapiens_hsa007500.89735808
54Hepatitis B_Homo sapiens_hsa051610.81876553
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81346208
56Endometrial cancer_Homo sapiens_hsa052130.79334928
57Apoptosis_Homo sapiens_hsa042100.79318259
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76816985
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76639276
60Lysine degradation_Homo sapiens_hsa003100.76388078
61Proteoglycans in cancer_Homo sapiens_hsa052050.75497264
62Adherens junction_Homo sapiens_hsa045200.75300823
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73742590
64Pancreatic cancer_Homo sapiens_hsa052120.72815924
65TGF-beta signaling pathway_Homo sapiens_hsa043500.70640877
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.69773389
67ErbB signaling pathway_Homo sapiens_hsa040120.68718949
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68542180
69Prostate cancer_Homo sapiens_hsa052150.68400834
70Biosynthesis of amino acids_Homo sapiens_hsa012300.68310065
71Hedgehog signaling pathway_Homo sapiens_hsa043400.68001800
72Selenocompound metabolism_Homo sapiens_hsa004500.67619817
73Pathways in cancer_Homo sapiens_hsa052000.67345560
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66364421
75Galactose metabolism_Homo sapiens_hsa000520.65123237
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62302491
77HIF-1 signaling pathway_Homo sapiens_hsa040660.61583961
78Shigellosis_Homo sapiens_hsa051310.61484320
79Fructose and mannose metabolism_Homo sapiens_hsa000510.60678062
80Viral myocarditis_Homo sapiens_hsa054160.60660636
81Glioma_Homo sapiens_hsa052140.60343286
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60046364
83Pentose phosphate pathway_Homo sapiens_hsa000300.60011462
84Alcoholism_Homo sapiens_hsa050340.59777676
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59605709
86Measles_Homo sapiens_hsa051620.59004403
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58833323
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.58795940
89Insulin signaling pathway_Homo sapiens_hsa049100.58628346
90VEGF signaling pathway_Homo sapiens_hsa043700.58522308
91T cell receptor signaling pathway_Homo sapiens_hsa046600.58082838
92Tight junction_Homo sapiens_hsa045300.56803650
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.54245795
94Legionellosis_Homo sapiens_hsa051340.53221923
95Wnt signaling pathway_Homo sapiens_hsa043100.51376868
96Toxoplasmosis_Homo sapiens_hsa051450.46827166
97Purine metabolism_Homo sapiens_hsa002300.46306228
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46049833
99Renal cell carcinoma_Homo sapiens_hsa052110.45995261
100Focal adhesion_Homo sapiens_hsa045100.44197564
101Prion diseases_Homo sapiens_hsa050200.42998407
102AMPK signaling pathway_Homo sapiens_hsa041520.41828174
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41562123
104Melanoma_Homo sapiens_hsa052180.41367095
105FoxO signaling pathway_Homo sapiens_hsa040680.41237813
106Influenza A_Homo sapiens_hsa051640.38941400
107Prolactin signaling pathway_Homo sapiens_hsa049170.38370394
108Pyruvate metabolism_Homo sapiens_hsa006200.38243583
109N-Glycan biosynthesis_Homo sapiens_hsa005100.37754663
110Folate biosynthesis_Homo sapiens_hsa007900.37376025
111Leishmaniasis_Homo sapiens_hsa051400.37298677
112Platelet activation_Homo sapiens_hsa046110.36594233
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36463629
114Hepatitis C_Homo sapiens_hsa051600.35848155
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35532080
116Sulfur relay system_Homo sapiens_hsa041220.35459563
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35038692
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.33803498
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33050237
120Osteoclast differentiation_Homo sapiens_hsa043800.33034677
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.31931191

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