RCC2P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of protein deacetylation (GO:0090312)6.79266298
2positive regulation of dendritic spine morphogenesis (GO:0061003)6.51919514
3telomere maintenance via semi-conservative replication (GO:0032201)6.27668615
4DNA strand elongation (GO:0022616)5.69236442
5DNA replication initiation (GO:0006270)5.56120217
6DNA strand elongation involved in DNA replication (GO:0006271)5.36329999
7telomere maintenance via recombination (GO:0000722)5.35730656
8mitotic recombination (GO:0006312)5.30053839
9negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)5.21723355
10somite rostral/caudal axis specification (GO:0032525)5.16364746
11RNA destabilization (GO:0050779)5.12928969
12forebrain neuron development (GO:0021884)5.12792928
13DNA unwinding involved in DNA replication (GO:0006268)5.07280077
14microtubule depolymerization (GO:0007019)4.86452415
15regulation of meiosis I (GO:0060631)4.85669149
16DNA ligation (GO:0006266)4.66397427
17response to misfolded protein (GO:0051788)4.49601424
18DNA synthesis involved in DNA repair (GO:0000731)4.41833228
19regulation of protein deacetylation (GO:0090311)4.32673380
20DNA replication-dependent nucleosome assembly (GO:0006335)4.18593636
21DNA replication-dependent nucleosome organization (GO:0034723)4.18593636
22cellular response to nitric oxide (GO:0071732)4.17849966
23membrane budding (GO:0006900)4.17814467
24response to folic acid (GO:0051593)4.16577570
25retinal ganglion cell axon guidance (GO:0031290)4.15712053
26cell wall macromolecule catabolic process (GO:0016998)4.02264360
27misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.96253138
28short-term memory (GO:0007614)3.95619516
29neuronal stem cell maintenance (GO:0097150)3.94009190
30detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.89569098
31detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.89500599
32mitotic sister chromatid segregation (GO:0000070)3.89309341
33positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.85889742
34positive regulation of dendritic spine development (GO:0060999)3.81403209
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.80564186
36synaptic transmission, cholinergic (GO:0007271)3.80023784
37apoptotic process involved in development (GO:1902742)3.72562168
38sister chromatid segregation (GO:0000819)3.71513717
39positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.69820390
40microtubule polymerization or depolymerization (GO:0031109)3.69749936
41regulation of double-strand break repair via homologous recombination (GO:0010569)3.67193135
42interkinetic nuclear migration (GO:0022027)3.63775435
43cell wall macromolecule metabolic process (GO:0044036)3.63623331
44telomere maintenance via telomere lengthening (GO:0010833)3.55570828
45hemoglobin metabolic process (GO:0020027)3.51862567
46regulation of penile erection (GO:0060405)3.42707876
47sister chromatid cohesion (GO:0007062)3.42396724
48translesion synthesis (GO:0019985)3.37193758
49DNA replication checkpoint (GO:0000076)3.36569111
50blastocyst development (GO:0001824)3.30767824
51ketone body metabolic process (GO:1902224)3.25700315
52negative regulation of microtubule polymerization (GO:0031115)3.24237928
53neurotransmitter-gated ion channel clustering (GO:0072578)3.18081868
54meiotic nuclear division (GO:0007126)3.17968598
55phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.16106735
56regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)3.15929405
57CENP-A containing nucleosome assembly (GO:0034080)3.15085414
58cellular ketone body metabolic process (GO:0046950)3.12741643
59cellular response to reactive nitrogen species (GO:1902170)3.12304568
60alternative mRNA splicing, via spliceosome (GO:0000380)3.10397466
61behavioral response to nicotine (GO:0035095)3.07566089
62regulation of transcription from RNA polymerase I promoter (GO:0006356)3.05637215
63positive regulation of DNA-templated transcription, initiation (GO:2000144)3.03998488
64circadian sleep/wake cycle process (GO:0022410)3.02994184
65maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00603828
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95747961
67negative regulation of multicellular organism growth (GO:0040015)2.94436802
68negative regulation of macroautophagy (GO:0016242)2.91412241
69protein localization to cilium (GO:0061512)2.88144926
70removal of superoxide radicals (GO:0019430)2.87505903
71cellular response to superoxide (GO:0071451)2.87505903
72cellular response to oxygen radical (GO:0071450)2.87505903
73chromatin remodeling at centromere (GO:0031055)2.86929503
74DNA biosynthetic process (GO:0071897)2.85698210
75male meiosis (GO:0007140)2.83011762
76tryptophan metabolic process (GO:0006568)2.81477804
77monoubiquitinated protein deubiquitination (GO:0035520)2.80347956
78mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.80260032
79alkaloid metabolic process (GO:0009820)2.78682355
80central nervous system neuron development (GO:0021954)2.78258632
81positive regulation of cellular amide metabolic process (GO:0034250)2.76337427
82gastrulation with mouth forming second (GO:0001702)2.76286396
83positive regulation of sodium ion transmembrane transport (GO:1902307)2.75800810
84positive regulation of histone deacetylation (GO:0031065)2.75195032
85interferon-gamma production (GO:0032609)2.75067565
86carnitine shuttle (GO:0006853)2.74181751
87nucleus localization (GO:0051647)2.71739764
88DNA damage response, detection of DNA damage (GO:0042769)2.71323428
89layer formation in cerebral cortex (GO:0021819)2.71246429
90microtubule nucleation (GO:0007020)2.70929106
91positive regulation of protein homodimerization activity (GO:0090073)2.70719029
92purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.68447576
93telomere maintenance (GO:0000723)2.67582513
94regulation of DNA endoreduplication (GO:0032875)2.66610841
95indolalkylamine metabolic process (GO:0006586)2.66307391
96telomere organization (GO:0032200)2.65560333
97ectodermal placode formation (GO:0060788)2.65057372
98kinetochore organization (GO:0051383)2.65009571
99termination of RNA polymerase II transcription (GO:0006369)2.64025721
100Peyers patch development (GO:0048541)2.63509336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.43050801
2E2F7_22180533_ChIP-Seq_HELA_Human7.33212512
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.41017978
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98644919
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92168970
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.89271804
7ESR1_15608294_ChIP-ChIP_MCF-7_Human2.64895472
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52509980
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49012560
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.44190970
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18781334
12E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human2.15850326
13TCF4_18268006_ChIP-ChIP_LS174T_Human2.06551419
14SOX2_19030024_ChIP-ChIP_MESCs_Mouse2.04116380
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01746630
16FUS_26573619_Chip-Seq_HEK293_Human2.01095299
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.98018356
18ETS1_20019798_ChIP-Seq_JURKAT_Human1.96619795
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.93427014
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93160821
21SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.87777599
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85053297
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81839580
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80622025
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79948413
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77610149
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.74061209
28TTF2_22483619_ChIP-Seq_HELA_Human1.70899482
29ZNF274_21170338_ChIP-Seq_K562_Hela1.65104555
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64857402
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60518997
32AR_21909140_ChIP-Seq_LNCAP_Human1.58220837
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.54785778
34EZH2_22144423_ChIP-Seq_EOC_Human1.49621099
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48983198
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48771762
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.47584321
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.46488653
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46273707
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45711295
41CIITA_25753668_ChIP-Seq_RAJI_Human1.45313537
42AR_21572438_ChIP-Seq_LNCaP_Human1.42369345
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42232517
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39266343
45FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.38873311
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36102127
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30803268
48GABP_19822575_ChIP-Seq_HepG2_Human1.29667264
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28559510
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28559510
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27818366
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23304976
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22139076
54VDR_22108803_ChIP-Seq_LS180_Human1.17776859
55RNF2_27304074_Chip-Seq_NSC_Mouse1.17587739
56NANOG_21062744_ChIP-ChIP_HESCs_Human1.17241419
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16416670
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15450298
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14927142
60ELK1_19687146_ChIP-ChIP_HELA_Human1.14491894
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10819791
62CBP_20019798_ChIP-Seq_JUKART_Human1.10819791
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07558305
64NCOR_22424771_ChIP-Seq_293T_Human1.07085464
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06149993
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05629407
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.03517076
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03076520
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.01501383
70SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00154222
71PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99858011
72KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99572194
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99514935
74VDR_23849224_ChIP-Seq_CD4+_Human0.99208147
75CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99037640
76TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.96277564
77ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95246917
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95210163
79SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94584120
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94497411
81DCP1A_22483619_ChIP-Seq_HELA_Human0.94345553
82SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.93677757
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92998042
84MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90804320
85MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88131701
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86939042
87MYC_18940864_ChIP-ChIP_HL60_Human0.85959223
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85749491
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.85642715
90KDM5A_27292631_Chip-Seq_BREAST_Human0.83444174
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.82978988
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.82333329
93HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81430677
94NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81049640
95TP53_22573176_ChIP-Seq_HFKS_Human0.80107918
96SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.79889690
97FOXP3_21729870_ChIP-Seq_TREG_Human0.79159009
98CBX2_22325352_ChIP-Seq_293T-Rex_Human0.78299340
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.77367053
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77095759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.96640277
2MP0003890_abnormal_embryonic-extraembry4.50786765
3MP0000516_abnormal_urinary_system4.23604215
4MP0005367_renal/urinary_system_phenotyp4.23604215
5MP0000372_irregular_coat_pigmentation4.05956791
6MP0000569_abnormal_digit_pigmentation4.05563882
7MP0005670_abnormal_white_adipose3.68030837
8MP0003136_yellow_coat_color3.37819594
9MP0003806_abnormal_nucleotide_metabolis3.37505999
10MP0009697_abnormal_copulation2.96143235
11MP0005171_absent_coat_pigmentation2.87987559
12MP0010094_abnormal_chromosome_stability2.59635922
13MP0002234_abnormal_pharynx_morphology2.34173484
14MP0002102_abnormal_ear_morphology2.27031585
15MP0005174_abnormal_tail_pigmentation2.22038469
16MP0001986_abnormal_taste_sensitivity2.18850575
17MP0002249_abnormal_larynx_morphology2.09777915
18MP0005266_abnormal_metabolism2.08973359
19MP0000015_abnormal_ear_pigmentation2.05419987
20MP0002822_catalepsy1.89412095
21MP0003111_abnormal_nucleus_morphology1.86482662
22MP0000566_synostosis1.85601736
23MP0008961_abnormal_basal_metabolism1.75740755
24MP0003077_abnormal_cell_cycle1.52773860
25MP0003880_abnormal_central_pattern1.52445222
26MP0004142_abnormal_muscle_tone1.51184985
27MP0003119_abnormal_digestive_system1.49634052
28MP0003693_abnormal_embryo_hatching1.47068648
29MP0003879_abnormal_hair_cell1.38358343
30MP0010368_abnormal_lymphatic_system1.36886220
31MP0002938_white_spotting1.36244182
32MP0003938_abnormal_ear_development1.29159328
33MP0000537_abnormal_urethra_morphology1.27518641
34MP0002098_abnormal_vibrissa_morphology1.27480130
35MP0005409_darkened_coat_color1.27286476
36MP0000371_diluted_coat_color1.26749349
37MP0000534_abnormal_ureter_morphology1.26571127
38MP0006035_abnormal_mitochondrial_morpho1.24001340
39MP0003943_abnormal_hepatobiliary_system1.23179638
40MP0000751_myopathy1.20073785
41MP0001501_abnormal_sleep_pattern1.19975246
42MP0008007_abnormal_cellular_replicative1.17739670
43MP0008932_abnormal_embryonic_tissue1.16792027
44MP0002132_abnormal_respiratory_system1.13864507
45MP0000955_abnormal_spinal_cord1.12696623
46MP0009379_abnormal_foot_pigmentation1.10637413
47MP0002095_abnormal_skin_pigmentation1.07501370
48MP0000383_abnormal_hair_follicle1.01441462
49MP0004133_heterotaxia0.94581250
50MP0005423_abnormal_somatic_nervous0.92606489
51MP0002075_abnormal_coat/hair_pigmentati0.91934669
52MP0002009_preneoplasia0.91197980
53MP0009278_abnormal_bone_marrow0.91093026
54MP0000678_abnormal_parathyroid_gland0.90709765
55MP0009046_muscle_twitch0.89517709
56MP0002736_abnormal_nociception_after0.89192360
57MP0001346_abnormal_lacrimal_gland0.88539422
58MP0002184_abnormal_innervation0.87489615
59MP0005076_abnormal_cell_differentiation0.84192389
60MP0004957_abnormal_blastocyst_morpholog0.84180552
61MP0002970_abnormal_white_adipose0.84167404
62MP0001486_abnormal_startle_reflex0.83686496
63MP0000631_abnormal_neuroendocrine_gland0.83370183
64MP0003937_abnormal_limbs/digits/tail_de0.83118276
65MP0008058_abnormal_DNA_repair0.82333470
66MP0003183_abnormal_peptide_metabolism0.82306386
67MP0002084_abnormal_developmental_patter0.81192802
68MP0003186_abnormal_redox_activity0.79958606
69MP0005376_homeostasis/metabolism_phenot0.79056101
70MP0001672_abnormal_embryogenesis/_devel0.78819355
71MP0005380_embryogenesis_phenotype0.78819355
72MP0001286_abnormal_eye_development0.76919887
73MP0004742_abnormal_vestibular_system0.75135156
74MP0002210_abnormal_sex_determination0.74590603
75MP0009115_abnormal_fat_cell0.70373392
76MP0001697_abnormal_embryo_size0.69329557
77MP0000681_abnormal_thyroid_gland0.66600360
78MP0001145_abnormal_male_reproductive0.66308551
79MP0003984_embryonic_growth_retardation0.64248706
80MP0003567_abnormal_fetal_cardiomyocyte0.62434644
81MP0002932_abnormal_joint_morphology0.62059198
82MP0003221_abnormal_cardiomyocyte_apopto0.61358317
83MP0002088_abnormal_embryonic_growth/wei0.60505337
84MP0003632_abnormal_nervous_system0.59414024
85MP0002751_abnormal_autonomic_nervous0.59008121
86MP0001730_embryonic_growth_arrest0.58764087
87MP0010678_abnormal_skin_adnexa0.58693439
88MP0002114_abnormal_axial_skeleton0.58400944
89MP0003936_abnormal_reproductive_system0.57865965
90MP0002735_abnormal_chemical_nociception0.56337283
91MP0004197_abnormal_fetal_growth/weight/0.56059269
92MP0002085_abnormal_embryonic_tissue0.56007995
93MP0000350_abnormal_cell_proliferation0.55500863
94MP0003698_abnormal_male_reproductive0.54650476
95MP0003861_abnormal_nervous_system0.54134220
96MP0001324_abnormal_eye_pigmentation0.53968973
97MP0004043_abnormal_pH_regulation0.52972098
98MP0002837_dystrophic_cardiac_calcinosis0.52006795
99MP0001186_pigmentation_phenotype0.51813676
100MP0002152_abnormal_brain_morphology0.51414453

Predicted human phenotypes

RankGene SetZ-score
1Failure to thrive in infancy (HP:0001531)5.57928629
2Split foot (HP:0001839)4.57524588
3Hypoplastic pelvis (HP:0008839)4.34666814
4Febrile seizures (HP:0002373)4.04011911
5Rib fusion (HP:0000902)4.03267754
6Severe global developmental delay (HP:0011344)3.72012908
7Focal motor seizures (HP:0011153)3.53285450
8Ankle clonus (HP:0011448)3.47311031
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.42217600
10Agammaglobulinemia (HP:0004432)3.29379679
11Hypoplasia of the pons (HP:0012110)3.08354114
12Breast hypoplasia (HP:0003187)3.07305536
13Chromsome breakage (HP:0040012)2.97137977
14Abnormality of homocysteine metabolism (HP:0010919)2.96917489
15Homocystinuria (HP:0002156)2.96917489
16Abnormality of methionine metabolism (HP:0010901)2.93741249
17High anterior hairline (HP:0009890)2.86410282
18Shoulder girdle muscle weakness (HP:0003547)2.85198365
19Small hand (HP:0200055)2.77949446
20Aplasia/Hypoplasia of the sacrum (HP:0008517)2.74262808
21Abnormal protein glycosylation (HP:0012346)2.69350918
22Abnormal glycosylation (HP:0012345)2.69350918
23Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69350918
24Abnormal protein N-linked glycosylation (HP:0012347)2.69350918
25Limb-girdle muscle atrophy (HP:0003797)2.67056499
26Broad alveolar ridges (HP:0000187)2.59727573
27Renal hypoplasia (HP:0000089)2.55454435
28Intestinal atresia (HP:0011100)2.54411972
29Alacrima (HP:0000522)2.53140357
30Oligodactyly (HP:0012165)2.51436369
31Poor coordination (HP:0002370)2.51187455
32Poor head control (HP:0002421)2.48566265
33Median cleft lip (HP:0000161)2.47841139
34Abnormality of the pons (HP:0007361)2.45259606
35Orthostatic hypotension (HP:0001278)2.40428643
36Volvulus (HP:0002580)2.40231153
37Midline defect of the nose (HP:0004122)2.39039204
38Deeply set eye (HP:0000490)2.38139535
39Abnormality of secondary sexual hair (HP:0009888)2.33373083
40Abnormality of the axillary hair (HP:0100134)2.33373083
41Rimmed vacuoles (HP:0003805)2.33021533
42Triphalangeal thumb (HP:0001199)2.32897984
43Congenital, generalized hypertrichosis (HP:0004540)2.31718328
44Meckel diverticulum (HP:0002245)2.31412947
45Abnormality of the ileum (HP:0001549)2.26476420
46Dysautonomia (HP:0002459)2.25477077
47Abnormal lung lobation (HP:0002101)2.24663402
48Birth length less than 3rd percentile (HP:0003561)2.23962091
49Absent radius (HP:0003974)2.19868459
50Hemorrhage of the eye (HP:0011885)2.18956240
51Progressive external ophthalmoplegia (HP:0000590)2.18771230
52Abnormal auditory evoked potentials (HP:0006958)2.15676751
53Absent thumb (HP:0009777)2.13130771
54Duodenal stenosis (HP:0100867)2.12898790
55Small intestinal stenosis (HP:0012848)2.12898790
56Amyotrophic lateral sclerosis (HP:0007354)2.12078601
57Methylmalonic aciduria (HP:0012120)2.11590890
58Aplasia/Hypoplasia involving the musculature (HP:0001460)2.11097336
59Central scotoma (HP:0000603)2.10963022
60Proximal placement of thumb (HP:0009623)2.10032474
61Overlapping toe (HP:0001845)2.09706945
62Absent forearm bone (HP:0003953)2.08712326
63Aplasia involving forearm bones (HP:0009822)2.08712326
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.04813801
65Abnormal respiratory epithelium morphology (HP:0012253)2.02734784
66Abnormal respiratory motile cilium morphology (HP:0005938)2.02734784
67Esophageal atresia (HP:0002032)2.02717559
68Papillary thyroid carcinoma (HP:0002895)2.02283636
69Supernumerary spleens (HP:0009799)2.02161287
70Methylmalonic acidemia (HP:0002912)1.96987439
71Facial hemangioma (HP:0000329)1.96330110
72Aplasia/Hypoplasia of the sternum (HP:0006714)1.93920182
73Large earlobe (HP:0009748)1.93747164
74Hypothermia (HP:0002045)1.93223777
75Decreased lacrimation (HP:0000633)1.92752278
76Scanning speech (HP:0002168)1.91867887
77Deviation of the thumb (HP:0009603)1.90676569
78Pelvic girdle muscle weakness (HP:0003749)1.89678759
79External ophthalmoplegia (HP:0000544)1.88584318
80Coarctation of aorta (HP:0001680)1.88321274
81Type I transferrin isoform profile (HP:0003642)1.86269335
82Multiple enchondromatosis (HP:0005701)1.85162333
83Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85112139
84Dicarboxylic aciduria (HP:0003215)1.85112139
85Exercise-induced myalgia (HP:0003738)1.84500278
86Gastrointestinal atresia (HP:0002589)1.84465996
87Abnormality of cochlea (HP:0000375)1.84195592
88Absent speech (HP:0001344)1.82886530
89Nephroblastoma (Wilms tumor) (HP:0002667)1.80912394
90Hypoplastic female external genitalia (HP:0012815)1.80450773
91Abnormality of sulfur amino acid metabolism (HP:0004339)1.79300889
92Abnormality of the duodenum (HP:0002246)1.77905502
93Woolly hair (HP:0002224)1.77615435
94Abnormality of the parathyroid morphology (HP:0011766)1.76631552
95Abnormality of the lacrimal duct (HP:0011481)1.76441083
96Embryonal renal neoplasm (HP:0011794)1.76029567
97Low anterior hairline (HP:0000294)1.75432349
98Nasolacrimal duct obstruction (HP:0000579)1.74002600
99Limited elbow extension (HP:0001377)1.73883114
100Hyperkalemia (HP:0002153)1.73187346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF17.09161672
2FGFR34.64916304
3CDC73.18570029
4MAP3K42.84472728
5UHMK12.50657773
6MAP4K22.47555184
7DYRK1A2.41334701
8PNCK2.40625363
9MAPK132.35633671
10MAP2K72.32115132
11MAP3K62.27501347
12PBK2.25162467
13CAMK1G2.22469079
14ZAK2.16477840
15LATS12.09463228
16WEE11.87060035
17NUAK11.86991226
18CAMK1D1.60809267
19NEK11.52578138
20MAP2K41.52149115
21CAMK41.46631795
22ATR1.38908151
23SRPK11.36841779
24CDK81.36492577
25TAOK11.36216449
26CCNB11.26544561
27CSF1R1.23050944
28BUB11.19722923
29WNK31.18159920
30TRIM281.17480750
31BCR1.10832854
32CHEK21.08848074
33RIPK41.08610351
34DYRK31.08257754
35MATK1.06053762
36NEK20.96225707
37SGK10.90648866
38ERBB20.88692601
39BMX0.87035571
40EPHB20.82288418
41MAP2K30.80664387
42CDK70.78163120
43FGR0.78067490
44LATS20.76287511
45MARK10.75678820
46EEF2K0.74999000
47PLK40.71357420
48CSNK1E0.70518367
49CHEK10.69579016
50MST40.68395437
51PASK0.67660953
52CDK11A0.67470496
53MKNK10.67244911
54CDK40.63179157
55BRSK10.62919088
56AURKA0.62643393
57MAP3K50.60859208
58CDK10.59007378
59ATM0.58094090
60CDK150.57130659
61AURKB0.56456473
62CDK20.55963180
63TTK0.55216838
64KDR0.54093358
65PLK10.53691903
66CDK180.53546575
67PRKACB0.48843853
68BMPR1B0.48261885
69ERBB30.46967994
70TNK20.46174034
71CDK30.41316435
72INSR0.41015836
73CSNK2A10.40784541
74CDK140.39554401
75EGFR0.37948985
76MKNK20.37646309
77CAMK2A0.36122706
78GSK3B0.35972908
79DYRK1B0.35822056
80MARK20.35715066
81CDK90.34960811
82MAPKAPK30.34364234
83MAPK100.32674764
84NTRK10.31731306
85PRKCZ0.31615453
86MET0.30816736
87MAPK90.30359585
88RPS6KA40.29969700
89MAPK140.29685570
90PRKAA20.29048958
91CSNK2A20.27934107
92RET0.27522874
93CAMK2B0.27307379
94CDK60.26825091
95CSNK1A10.26409110
96TRPM70.26276208
97FLT30.25955247
98MINK10.24473376
99PRKACG0.23670353
100PRKDC0.23261861

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.82384120
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.66519544
3Mismatch repair_Homo sapiens_hsa034304.33456181
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.14534494
5Base excision repair_Homo sapiens_hsa034103.69188273
6Vitamin B6 metabolism_Homo sapiens_hsa007503.54836855
7Homologous recombination_Homo sapiens_hsa034402.96757655
8Taste transduction_Homo sapiens_hsa047422.92824738
9Fanconi anemia pathway_Homo sapiens_hsa034602.83799541
10Nucleotide excision repair_Homo sapiens_hsa034202.17472669
11Spliceosome_Homo sapiens_hsa030402.07641207
12Cysteine and methionine metabolism_Homo sapiens_hsa002702.06267868
13Pyruvate metabolism_Homo sapiens_hsa006202.05337028
14Cell cycle_Homo sapiens_hsa041101.90370941
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.89716971
16Butanoate metabolism_Homo sapiens_hsa006501.88832567
17Ether lipid metabolism_Homo sapiens_hsa005651.85231274
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66444012
19Propanoate metabolism_Homo sapiens_hsa006401.40873171
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.36663782
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33144020
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28595477
23Pyrimidine metabolism_Homo sapiens_hsa002401.24924812
24Oocyte meiosis_Homo sapiens_hsa041141.21385604
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20725299
26Folate biosynthesis_Homo sapiens_hsa007901.19560438
27Primary immunodeficiency_Homo sapiens_hsa053401.13391902
28Steroid biosynthesis_Homo sapiens_hsa001001.09822968
29RNA transport_Homo sapiens_hsa030131.03022013
30RNA polymerase_Homo sapiens_hsa030200.95376685
31Nicotine addiction_Homo sapiens_hsa050330.94490315
32One carbon pool by folate_Homo sapiens_hsa006700.92751681
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91345076
34Synaptic vesicle cycle_Homo sapiens_hsa047210.90579930
35Morphine addiction_Homo sapiens_hsa050320.89805012
36Glucagon signaling pathway_Homo sapiens_hsa049220.88598858
37Huntingtons disease_Homo sapiens_hsa050160.87249693
38mRNA surveillance pathway_Homo sapiens_hsa030150.85164423
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83503863
40Alcoholism_Homo sapiens_hsa050340.80502499
41Glycerophospholipid metabolism_Homo sapiens_hsa005640.75062775
42GABAergic synapse_Homo sapiens_hsa047270.73036673
43Oxidative phosphorylation_Homo sapiens_hsa001900.71533066
44Fatty acid biosynthesis_Homo sapiens_hsa000610.63495628
45TGF-beta signaling pathway_Homo sapiens_hsa043500.62676637
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62527574
47Circadian rhythm_Homo sapiens_hsa047100.61586541
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59398415
49Collecting duct acid secretion_Homo sapiens_hsa049660.59277862
50Dopaminergic synapse_Homo sapiens_hsa047280.56997929
51AMPK signaling pathway_Homo sapiens_hsa041520.54147045
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53625151
53Parkinsons disease_Homo sapiens_hsa050120.53100259
54Glutamatergic synapse_Homo sapiens_hsa047240.52138037
55Systemic lupus erythematosus_Homo sapiens_hsa053220.52081295
56Purine metabolism_Homo sapiens_hsa002300.51871370
57Ribosome_Homo sapiens_hsa030100.50400913
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49901658
59beta-Alanine metabolism_Homo sapiens_hsa004100.46781548
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46748743
61Metabolic pathways_Homo sapiens_hsa011000.43918815
62Tryptophan metabolism_Homo sapiens_hsa003800.40401716
63p53 signaling pathway_Homo sapiens_hsa041150.39170235
64Peroxisome_Homo sapiens_hsa041460.37636775
65Viral carcinogenesis_Homo sapiens_hsa052030.37253651
66Cholinergic synapse_Homo sapiens_hsa047250.37187556
67Protein export_Homo sapiens_hsa030600.36313960
68N-Glycan biosynthesis_Homo sapiens_hsa005100.35606840
69Olfactory transduction_Homo sapiens_hsa047400.35291925
70Non-homologous end-joining_Homo sapiens_hsa034500.33685398
71Arginine and proline metabolism_Homo sapiens_hsa003300.32370385
72Glutathione metabolism_Homo sapiens_hsa004800.31881312
73Histidine metabolism_Homo sapiens_hsa003400.29533272
74Axon guidance_Homo sapiens_hsa043600.29497062
75RNA degradation_Homo sapiens_hsa030180.28730186
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28579793
77Circadian entrainment_Homo sapiens_hsa047130.28457872
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27844171
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.25334038
80Thyroid hormone synthesis_Homo sapiens_hsa049180.21391001
81Regulation of autophagy_Homo sapiens_hsa041400.21078195
82Phototransduction_Homo sapiens_hsa047440.20984220
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20755196
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20669531
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20312874
86Cocaine addiction_Homo sapiens_hsa050300.20159141
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18377080
88Pertussis_Homo sapiens_hsa051330.18255757
89Proteasome_Homo sapiens_hsa030500.17734978
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17327336
91Basal transcription factors_Homo sapiens_hsa030220.17002625
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15768613
93Linoleic acid metabolism_Homo sapiens_hsa005910.14243955
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12530333
95Sulfur relay system_Homo sapiens_hsa041220.12060493
96Glycerolipid metabolism_Homo sapiens_hsa005610.11025065
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10449751
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10337389
99Sphingolipid metabolism_Homo sapiens_hsa006000.09679371
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.08835208

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