RCE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)8.51035224
2DNA strand renaturation (GO:0000733)7.81151679
3negative regulation of cell aging (GO:0090344)7.75757652
4regulation of skeletal muscle contraction (GO:0014819)6.84270967
5protein carboxylation (GO:0018214)6.69883221
6peptidyl-glutamic acid carboxylation (GO:0017187)6.69883221
7mitotic cell cycle arrest (GO:0071850)6.45049526
8DNA deamination (GO:0045006)6.16096258
9cellular response to ATP (GO:0071318)6.07721936
10negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.98156932
11regulation of cytokine production involved in inflammatory response (GO:1900015)5.79977357
12meiotic chromosome segregation (GO:0045132)5.61344048
13regulation of synapse structural plasticity (GO:0051823)5.51542116
14adenosine receptor signaling pathway (GO:0001973)5.45336569
15ribosomal small subunit assembly (GO:0000028)5.28688053
16maturation of SSU-rRNA (GO:0030490)5.19211992
17G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.18998851
18transepithelial transport (GO:0070633)5.06900727
19DNA strand elongation involved in DNA replication (GO:0006271)5.04213608
20lens fiber cell differentiation (GO:0070306)4.96316540
21viral transcription (GO:0019083)4.96219879
22translational termination (GO:0006415)4.87022378
23telomere maintenance via semi-conservative replication (GO:0032201)4.86227374
24DNA strand elongation (GO:0022616)4.79815533
25granulocyte differentiation (GO:0030851)4.72908007
26proteasome assembly (GO:0043248)4.65306086
27base-excision repair, AP site formation (GO:0006285)4.60050689
28ribosomal small subunit biogenesis (GO:0042274)4.56697982
29rRNA methylation (GO:0031167)4.54351525
30translational elongation (GO:0006414)4.53563786
31ribosomal large subunit biogenesis (GO:0042273)4.43352592
32formation of translation preinitiation complex (GO:0001731)4.42511743
33purinergic nucleotide receptor signaling pathway (GO:0035590)4.39773570
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.39022538
35DNA replication initiation (GO:0006270)4.35309519
36cotranslational protein targeting to membrane (GO:0006613)4.29604840
37estrogen biosynthetic process (GO:0006703)4.29421927
38proline biosynthetic process (GO:0006561)4.27629882
39protein targeting to ER (GO:0045047)4.26787553
40UV protection (GO:0009650)4.20390763
41translational initiation (GO:0006413)4.17814752
42nucleotide-sugar biosynthetic process (GO:0009226)4.15274801
43detection of light stimulus involved in visual perception (GO:0050908)4.14775804
44detection of light stimulus involved in sensory perception (GO:0050962)4.14775804
45telomere maintenance via recombination (GO:0000722)4.12041104
46phosphatidylglycerol biosynthetic process (GO:0006655)4.09029399
47sulfur amino acid catabolic process (GO:0000098)4.06691951
48protein localization to endoplasmic reticulum (GO:0070972)4.05618155
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.04855105
50establishment of protein localization to endoplasmic reticulum (GO:0072599)4.03158263
51regulation of cell aging (GO:0090342)4.01318220
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.00592981
53positive regulation of heat generation (GO:0031652)3.97925474
54pseudouridine synthesis (GO:0001522)3.93917731
55ribonucleoprotein complex biogenesis (GO:0022613)3.93201340
56purine deoxyribonucleotide catabolic process (GO:0009155)3.91635004
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.91086062
58nucleobase biosynthetic process (GO:0046112)3.90965623
59viral life cycle (GO:0019058)3.89030506
60semaphorin-plexin signaling pathway (GO:0071526)3.85371634
61mannose metabolic process (GO:0006013)3.82600227
62DNA unwinding involved in DNA replication (GO:0006268)3.81113265
63protein insertion into membrane (GO:0051205)3.79923683
64purine ribonucleotide transport (GO:0015868)3.78098541
65mitotic recombination (GO:0006312)3.76406540
66nucleotide-excision repair, DNA gap filling (GO:0006297)3.76287643
67cellular protein complex disassembly (GO:0043624)3.76011576
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.75834990
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.72658860
70dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.72520405
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.71734928
72negative regulation of ligase activity (GO:0051352)3.71034289
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.71034289
74telomere maintenance via telomere lengthening (GO:0010833)3.69693801
75adenine nucleotide transport (GO:0051503)3.69359627
76folic acid transport (GO:0015884)3.65345843
77purine nucleobase biosynthetic process (GO:0009113)3.65109648
78folic acid-containing compound biosynthetic process (GO:0009396)3.64856377
79deoxyribonucleotide catabolic process (GO:0009264)3.62851565
80translation (GO:0006412)3.60007425
81ribosome biogenesis (GO:0042254)3.57483218
82rRNA processing (GO:0006364)3.55588314
83DNA replication checkpoint (GO:0000076)3.55477150
84regulation of phospholipid biosynthetic process (GO:0071071)3.50012924
85protein retention in ER lumen (GO:0006621)3.47197420
86positive regulation of protein kinase C signaling (GO:0090037)3.46831525
87spliceosomal snRNP assembly (GO:0000387)3.43928621
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.42192489
89nucleoside transmembrane transport (GO:1901642)3.41105871
90rRNA metabolic process (GO:0016072)3.40330033
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.39035695
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.39035695
93protein complex disassembly (GO:0043241)3.38749276
94phosphate ion homeostasis (GO:0055062)3.38542763
95trivalent inorganic anion homeostasis (GO:0072506)3.38542763
96ribosome assembly (GO:0042255)3.38115168
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.37546010
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.37546010
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.37546010
100rRNA modification (GO:0000154)3.37054465
101deoxyribose phosphate catabolic process (GO:0046386)3.36013530
102sphingomyelin metabolic process (GO:0006684)3.34394788
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.34115768
104tRNA modification (GO:0006400)3.32676890
105negative regulation of interleukin-8 production (GO:0032717)3.32309724
106signal transduction involved in DNA damage checkpoint (GO:0072422)3.29737662
107signal transduction involved in DNA integrity checkpoint (GO:0072401)3.29737662
108nucleotide salvage (GO:0043173)3.29061146
109purinergic receptor signaling pathway (GO:0035587)3.28034164
110response to ATP (GO:0033198)3.27520620
111regulation of cellular amino acid metabolic process (GO:0006521)3.26480660
112signal transduction involved in cell cycle checkpoint (GO:0072395)3.24041716
113positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.23855767
114sensory perception of taste (GO:0050909)3.22672524
115macromolecular complex disassembly (GO:0032984)3.22081014
116type B pancreatic cell proliferation (GO:0044342)3.21869481
117G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.21680263
118sphingosine metabolic process (GO:0006670)3.21554356
119pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21254712
120transcription elongation from RNA polymerase III promoter (GO:0006385)3.20709979
121termination of RNA polymerase III transcription (GO:0006386)3.20709979
122protein deneddylation (GO:0000338)3.16632096
123transcription-coupled nucleotide-excision repair (GO:0006283)3.16501014
124cellular component biogenesis (GO:0044085)3.15858938
125pyrimidine nucleotide catabolic process (GO:0006244)3.15608563
126positive regulation of ligase activity (GO:0051351)3.14920016
127cellular anion homeostasis (GO:0030002)3.14892606
128cell cycle G1/S phase transition (GO:0044843)3.14442867
129G1/S transition of mitotic cell cycle (GO:0000082)3.14442867
130nuclear-transcribed mRNA catabolic process (GO:0000956)3.13121145
131antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.13018047
132grooming behavior (GO:0007625)3.11548315
133maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.10775634
134L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10754315
135positive regulation of TOR signaling (GO:0032008)3.10124354
136cullin deneddylation (GO:0010388)3.08208845
137proline metabolic process (GO:0006560)3.06985712
138negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.04280100
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03773913
140exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99675974
141mRNA catabolic process (GO:0006402)2.96262237
142regulation of ubiquitin-protein transferase activity (GO:0051438)2.94110969
143protein localization to kinetochore (GO:0034501)2.93132235
144spliceosomal complex assembly (GO:0000245)2.91905090
145pteridine-containing compound biosynthetic process (GO:0042559)2.91799664
146metallo-sulfur cluster assembly (GO:0031163)2.91779358
147iron-sulfur cluster assembly (GO:0016226)2.91779358
148establishment of integrated proviral latency (GO:0075713)2.91302100
149diol metabolic process (GO:0034311)2.90907260
150regulation of nuclear cell cycle DNA replication (GO:0033262)2.90904544
151folic acid metabolic process (GO:0046655)2.89553588
152CENP-A containing nucleosome assembly (GO:0034080)2.88264679
153regulation of ligase activity (GO:0051340)2.87927067
154RNA catabolic process (GO:0006401)2.87205734
155nucleoside transport (GO:0015858)2.86107338
156positive regulation of cell cycle arrest (GO:0071158)2.85898106
157peptidyl-glutamic acid modification (GO:0018200)2.85585964
158nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84695989
159mitotic nuclear envelope disassembly (GO:0007077)2.84505598
160mitotic metaphase plate congression (GO:0007080)2.84211199
161purine nucleotide transport (GO:0015865)2.83665934
162melanin biosynthetic process (GO:0042438)2.82456640
163nucleoside salvage (GO:0043174)2.81322486
1647-methylguanosine mRNA capping (GO:0006370)2.80774280
165DNA duplex unwinding (GO:0032508)2.80771976
166chromatin remodeling at centromere (GO:0031055)2.80759294
167IMP biosynthetic process (GO:0006188)2.80505310
168DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.80278934
169endocytic recycling (GO:0032456)2.80003655
170ncRNA processing (GO:0034470)2.79462438
171protein K11-linked ubiquitination (GO:0070979)2.78932826
172RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78315246
173tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78315246
174protein targeting to membrane (GO:0006612)2.77553089
175nucleobase-containing small molecule interconversion (GO:0015949)2.77031768
176positive regulation of megakaryocyte differentiation (GO:0045654)2.75834076
177regulation of chromatin binding (GO:0035561)2.75744242
178kinetochore assembly (GO:0051382)2.75686332
179cardiolipin metabolic process (GO:0032048)2.75092034
180nucleotide transmembrane transport (GO:1901679)2.71399257
181positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.68882799
182regulation of heat generation (GO:0031650)2.68003949
183DNA geometric change (GO:0032392)2.66677383
184phosphatidylethanolamine biosynthetic process (GO:0006646)2.65040259
185pyrimidine-containing compound salvage (GO:0008655)2.64497835
186pyrimidine nucleoside salvage (GO:0043097)2.64497835
187pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.63790077
188behavioral response to nicotine (GO:0035095)2.63401469
189mitochondrial calcium ion transport (GO:0006851)2.60495494
190piRNA metabolic process (GO:0034587)2.59409895
191glutathione biosynthetic process (GO:0006750)2.58604152
192oligosaccharide catabolic process (GO:0009313)2.58400492
193DNA damage response, signal transduction resulting in transcription (GO:0042772)2.54659961
194melanin metabolic process (GO:0006582)2.54171388
195respiratory chain complex IV assembly (GO:0008535)2.53870549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.13678412
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.22577370
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.14728778
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35607472
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28926844
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.21138760
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.07273318
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.07010495
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00867040
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.89757969
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80221067
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76941694
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73208219
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54221072
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53300784
16LXR_22292898_ChIP-Seq_THP-1_Human2.50396751
17XRN2_22483619_ChIP-Seq_HELA_Human2.47925851
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46276246
19* P68_20966046_ChIP-Seq_HELA_Human2.42762853
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.29658629
21VDR_23849224_ChIP-Seq_CD4+_Human2.29277161
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25047186
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24401478
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23222149
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19803296
26DCP1A_22483619_ChIP-Seq_HELA_Human2.18571957
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.15699095
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10611395
29MAF_26560356_Chip-Seq_TH2_Human2.05244987
30STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04622309
31GABP_19822575_ChIP-Seq_HepG2_Human2.02926443
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01889913
33FOXP3_21729870_ChIP-Seq_TREG_Human1.99124545
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.98115996
35RACK7_27058665_Chip-Seq_MCF-7_Human1.97218933
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96368132
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95673692
38E2F1_20622854_ChIP-Seq_HELA_Human1.90621824
39TTF2_22483619_ChIP-Seq_HELA_Human1.89499177
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86868630
41BCL6_27268052_Chip-Seq_Bcells_Human1.85951056
42* BCOR_27268052_Chip-Seq_Bcells_Human1.82536764
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81290292
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.79470065
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78119974
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.77846124
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74385368
48PHF8_20622854_ChIP-Seq_HELA_Human1.73196340
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69599034
50* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.69136889
51FOXP1_21924763_ChIP-Seq_HESCs_Human1.69081649
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.67937371
53MAF_26560356_Chip-Seq_TH1_Human1.67319047
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63105465
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63028652
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62537432
57MYC_22102868_ChIP-Seq_BL_Human1.61573824
58VDR_24763502_ChIP-Seq_THP-1_Human1.61245657
59RARB_24833708_ChIP-Seq_LIVER_Mouse1.60846307
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60281093
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59953982
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59683505
63CTCF_21964334_Chip-Seq_Bcells_Human1.57473725
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.57212860
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.56942671
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56068817
67* CIITA_25753668_ChIP-Seq_RAJI_Human1.56030267
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55424819
69CTCF_27219007_Chip-Seq_Bcells_Human1.54454205
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.53411088
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.52758266
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52567231
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51826448
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51646884
75* RARA_24833708_ChIP-Seq_LIVER_Mouse1.51148897
76* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.50712700
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50544712
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48093933
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47844037
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47625636
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47568869
82AR_21909140_ChIP-Seq_LNCAP_Human1.47177534
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46879896
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46322809
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.46237718
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45698578
87SMC4_20622854_ChIP-Seq_HELA_Human1.44376192
88* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.42298330
89VDR_21846776_ChIP-Seq_THP-1_Human1.40993727
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40494483
91KDM2B_26808549_Chip-Seq_DND41_Human1.40171244
92* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37412566
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36737670
94UTX_26944678_Chip-Seq_JUKART_Human1.36151148
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33150809
96KDM5A_27292631_Chip-Seq_BREAST_Human1.32340674
97CTCF_20526341_ChIP-Seq_ESCs_Human1.31790211
98TFEB_21752829_ChIP-Seq_HELA_Human1.31453203
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30953814
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.29550377
101ELK1_19687146_ChIP-ChIP_HELA_Human1.29114487
102CTCF_21964334_ChIP-Seq_BJAB-B_Human1.28785528
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28264220
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25879922
105RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24346237
106CREB1_26743006_Chip-Seq_LNCaP_Human1.23690089
107* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23382599
108EGR1_19374776_ChIP-ChIP_THP-1_Human1.23059871
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21507904
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20756253
111ATF3_27146783_Chip-Seq_COLON_Human1.20178855
112CTCF_26484167_Chip-Seq_Bcells_Mouse1.19984678
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19966776
114ETS1_21867929_ChIP-Seq_TH2_Mouse1.19728424
115* TP53_22127205_ChIP-Seq_IMR90_Human1.18459930
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17239155
117STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17229960
118IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16293371
119SA1_27219007_Chip-Seq_Bcells_Human1.16219162
120* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15992928
121TCF7_22412390_ChIP-Seq_EML_Mouse1.15478976
122ELK1_22589737_ChIP-Seq_MCF10A_Human1.14576338
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13425139
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12962415
125SPI1_23547873_ChIP-Seq_NB4_Human1.12845387
126* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12712216
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12634419
128TP63_19390658_ChIP-ChIP_HaCaT_Human1.12068505
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10241686
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09724491
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09668872
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09224815
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08146114
134GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02240412
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00501260
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00248473
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99794732
138* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99028351
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96453934
140MYC_18940864_ChIP-ChIP_HL60_Human0.93104439
141RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92670488
142SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91692585
143CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91229474
144FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86467813
145* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86295396
146ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86277816
147CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85827873
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.85475240
149* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84395852
150EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83877499
151GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82453470
152TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80304253
153OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80245531
154IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80176026
155NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79647756
156TP63_17297297_ChIP-ChIP_HaCaT_Human0.79340460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation6.22939974
2MP0003693_abnormal_embryo_hatching5.89074027
3MP0001986_abnormal_taste_sensitivity4.62372356
4MP0005174_abnormal_tail_pigmentation4.48290929
5MP0004957_abnormal_blastocyst_morpholog4.37306557
6MP0005423_abnormal_somatic_nervous4.29833480
7MP0003136_yellow_coat_color3.99917577
8MP0010094_abnormal_chromosome_stability3.71233275
9MP0003111_abnormal_nucleus_morphology3.70543971
10MP0003077_abnormal_cell_cycle3.61387736
11MP0008875_abnormal_xenobiotic_pharmacok3.51032320
12MP0005083_abnormal_biliary_tract3.24919587
13MP0008057_abnormal_DNA_replication3.00736030
14MP0008058_abnormal_DNA_repair2.84218066
15MP0001188_hyperpigmentation2.74053008
16MP0008932_abnormal_embryonic_tissue2.70694487
17MP0008007_abnormal_cellular_replicative2.68786587
18MP0001661_extended_life_span2.67246865
19MP0003453_abnormal_keratinocyte_physiol2.48847163
20MP0002254_reproductive_system_inflammat2.42681383
21MP0000490_abnormal_crypts_of2.36510285
22MP0005409_darkened_coat_color2.26987029
23MP0010352_gastrointestinal_tract_polyps2.23440681
24MP0000751_myopathy2.23364504
25MP0001756_abnormal_urination2.20223903
26MP0005058_abnormal_lysosome_morphology2.16731113
27MP0003123_paternal_imprinting2.15456019
28MP0003763_abnormal_thymus_physiology2.07368735
29MP0000750_abnormal_muscle_regeneration2.05731434
30MP0009333_abnormal_splenocyte_physiolog1.98996584
31MP0003806_abnormal_nucleotide_metabolis1.97317701
32MP0003786_premature_aging1.89918531
33MP0002396_abnormal_hematopoietic_system1.89074964
34MP0001730_embryonic_growth_arrest1.88630168
35MP0000350_abnormal_cell_proliferation1.76651726
36MP0003186_abnormal_redox_activity1.73429084
37MP0003718_maternal_effect1.71559293
38MP0001968_abnormal_touch/_nociception1.68881579
39MP0005410_abnormal_fertilization1.65453318
40MP0001502_abnormal_circadian_rhythm1.65332705
41MP0003315_abnormal_perineum_morphology1.61100330
42MP0006054_spinal_hemorrhage1.50132934
43MP0002736_abnormal_nociception_after1.48328241
44MP0005076_abnormal_cell_differentiation1.48193646
45MP0000313_abnormal_cell_death1.47297115
46MP0002019_abnormal_tumor_incidence1.45240885
47MP0000685_abnormal_immune_system1.43024709
48MP0000538_abnormal_urinary_bladder1.42928249
49* MP0002080_prenatal_lethality1.38749443
50MP0000689_abnormal_spleen_morphology1.38435707
51MP0003878_abnormal_ear_physiology1.38413694
52MP0005377_hearing/vestibular/ear_phenot1.38413694
53MP0001697_abnormal_embryo_size1.37902503
54MP0010030_abnormal_orbit_morphology1.37783696
55MP0002398_abnormal_bone_marrow1.37341320
56MP0002722_abnormal_immune_system1.36815449
57MP0002132_abnormal_respiratory_system1.35622261
58MP0004808_abnormal_hematopoietic_stem1.35130088
59MP0000358_abnormal_cell_content/1.34736895
60MP0005332_abnormal_amino_acid1.33206166
61MP0001545_abnormal_hematopoietic_system1.32954966
62MP0005397_hematopoietic_system_phenotyp1.32954966
63MP0003436_decreased_susceptibility_to1.30677205
64MP0005075_abnormal_melanosome_morpholog1.28406984
65MP0006036_abnormal_mitochondrial_physio1.28355238
66MP0009278_abnormal_bone_marrow1.27399858
67MP0000015_abnormal_ear_pigmentation1.27019731
68MP0001853_heart_inflammation1.27018573
69MP0009840_abnormal_foam_cell1.25495693
70MP0001672_abnormal_embryogenesis/_devel1.21146341
71MP0005380_embryogenesis_phenotype1.21146341
72MP0002429_abnormal_blood_cell1.20818267
73MP0000703_abnormal_thymus_morphology1.19539795
74MP0004185_abnormal_adipocyte_glucose1.19469037
75MP0000858_altered_metastatic_potential1.19218365
76MP0001835_abnormal_antigen_presentation1.18614099
77MP0008877_abnormal_DNA_methylation1.18563751
78MP0005671_abnormal_response_to1.15372439
79MP0005257_abnormal_intraocular_pressure1.13399175
80MP0003984_embryonic_growth_retardation1.11056464
81MP0004381_abnormal_hair_follicle1.11004041
82MP0000716_abnormal_immune_system1.09498161
83MP0002088_abnormal_embryonic_growth/wei1.07715790
84MP0008260_abnormal_autophagy1.07216782
85MP0004019_abnormal_vitamin_homeostasis1.06918314
86MP0000003_abnormal_adipose_tissue1.04604619
87MP0009785_altered_susceptibility_to1.03781558
88MP0000465_gastrointestinal_hemorrhage1.03591811
89MP0003866_abnormal_defecation1.03274359
90MP0002420_abnormal_adaptive_immunity1.02170144
91MP0000747_muscle_weakness1.01685892
92MP0001819_abnormal_immune_cell1.00624964
93MP0002163_abnormal_gland_morphology1.00451452
94MP0002160_abnormal_reproductive_system0.99499074
95MP0001800_abnormal_humoral_immune0.99355259
96MP0002452_abnormal_antigen_presenting0.99251722
97MP0002405_respiratory_system_inflammati0.98564953
98* MP0005330_cardiomyopathy0.98002865
99MP0000470_abnormal_stomach_morphology0.96880571
100MP0005365_abnormal_bile_salt0.96842262
101MP0002085_abnormal_embryonic_tissue0.96399198
102MP0002723_abnormal_immune_serum0.96151817
103MP0006035_abnormal_mitochondrial_morpho0.96046032
104MP0010155_abnormal_intestine_physiology0.95751774
105MP0005584_abnormal_enzyme/coenzyme_acti0.94838789
106MP0004133_heterotaxia0.92514083
107MP0004130_abnormal_muscle_cell0.91768710
108MP0002210_abnormal_sex_determination0.90349877
109MP0005084_abnormal_gallbladder_morpholo0.89861476
110MP0005000_abnormal_immune_tolerance0.87987694
111MP0005025_abnormal_response_to0.87183104
112MP0009931_abnormal_skin_appearance0.86315507
113MP0000477_abnormal_intestine_morphology0.85900069
114MP0005384_cellular_phenotype0.84617721
115MP0002796_impaired_skin_barrier0.84322143
116MP0001145_abnormal_male_reproductive0.84091566
117MP0009643_abnormal_urine_homeostasis0.83956773
118MP0002086_abnormal_extraembryonic_tissu0.83772417
119MP0003448_altered_tumor_morphology0.81192452
120MP0010771_integument_phenotype0.80470767
121MP0002735_abnormal_chemical_nociception0.77731488
122MP0003011_delayed_dark_adaptation0.76606055
123MP0005023_abnormal_wound_healing0.76245818
124MP0001727_abnormal_embryo_implantation0.76166454
125MP0002084_abnormal_developmental_patter0.75797312
126MP0000013_abnormal_adipose_tissue0.74315340
127MP0005451_abnormal_body_composition0.74046539
128MP0001324_abnormal_eye_pigmentation0.73666263
129MP0005501_abnormal_skin_physiology0.72996581
130MP0001929_abnormal_gametogenesis0.72966108
131MP0003656_abnormal_erythrocyte_physiolo0.72531292
132MP0002638_abnormal_pupillary_reflex0.72322738
133MP0005621_abnormal_cell_physiology0.72307999
134MP0006292_abnormal_olfactory_placode0.72171703
135MP0001119_abnormal_female_reproductive0.71097437
136MP0001765_abnormal_ion_homeostasis0.70502728
137MP0009379_abnormal_foot_pigmentation0.70124464
138MP0003941_abnormal_skin_development0.69892395
139MP0000678_abnormal_parathyroid_gland0.69758909
140MP0010307_abnormal_tumor_latency0.69553191
141MP0001664_abnormal_digestion0.69317318
142MP0004197_abnormal_fetal_growth/weight/0.68126240
143MP0001905_abnormal_dopamine_level0.67604638
144MP0003137_abnormal_impulse_conducting0.67499453
145MP0005389_reproductive_system_phenotype0.67260686
146MP0002148_abnormal_hypersensitivity_rea0.67072729
147MP0001216_abnormal_epidermal_layer0.67021377
148MP0003705_abnormal_hypodermis_morpholog0.66711117
149MP0001542_abnormal_bone_strength0.65691733
150MP0001191_abnormal_skin_condition0.65383671
151MP0000653_abnormal_sex_gland0.63515746
152MP0001845_abnormal_inflammatory_respons0.61954592
153MP0001764_abnormal_homeostasis0.61949313
154MP0001346_abnormal_lacrimal_gland0.61614217
155MP0002089_abnormal_postnatal_growth/wei0.61462027
156MP0005375_adipose_tissue_phenotype0.61029939
157* MP0000367_abnormal_coat/_hair0.60955797
158MP0001873_stomach_inflammation0.60173192
159MP0003567_abnormal_fetal_cardiomyocyte0.60020757
160MP0005666_abnormal_adipose_tissue0.59707921
161MP0008789_abnormal_olfactory_epithelium0.59646629
162MP0001919_abnormal_reproductive_system0.58241051
163MP0003172_abnormal_lysosome_physiology0.57228608
164MP0002136_abnormal_kidney_physiology0.56443196
165MP0005551_abnormal_eye_electrophysiolog0.56199530

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)7.03184105
2Rib fusion (HP:0000902)5.76127084
3Dyschromatopsia (HP:0007641)5.60250141
4Renal Fanconi syndrome (HP:0001994)5.46070093
5Mesangial abnormality (HP:0001966)5.35840188
6Abnormality of cells of the erythroid lineage (HP:0012130)5.12534177
7Abnormal number of erythroid precursors (HP:0012131)5.00166970
8Reticulocytopenia (HP:0001896)4.86478550
9Abnormality of the intrinsic pathway (HP:0010989)4.56372477
10Rectal fistula (HP:0100590)4.55404481
11Rectovaginal fistula (HP:0000143)4.55404481
12Attenuation of retinal blood vessels (HP:0007843)4.55227199
13Hemorrhage of the eye (HP:0011885)4.41949492
14Vaginal fistula (HP:0004320)4.35015025
15Birth length less than 3rd percentile (HP:0003561)4.34983364
16Aplastic anemia (HP:0001915)4.29801535
17Thin bony cortex (HP:0002753)4.21975461
18Prolonged partial thromboplastin time (HP:0003645)4.19508563
19Intestinal fistula (HP:0100819)4.13503274
20Increased muscle lipid content (HP:0009058)4.09352777
21Facial hemangioma (HP:0000329)4.00482398
22Joint hemorrhage (HP:0005261)3.98132620
23Carpal bone hypoplasia (HP:0001498)3.87157539
24Oral leukoplakia (HP:0002745)3.86298708
25Ulnar bowing (HP:0003031)3.85067698
26Annular pancreas (HP:0001734)3.70414597
27Akinesia (HP:0002304)3.63644620
28Microretrognathia (HP:0000308)3.63574130
29Choroideremia (HP:0001139)3.61741860
30Decreased electroretinogram (ERG) amplitude (HP:0000654)3.59617581
31Facial diplegia (HP:0001349)3.58303215
32Rough bone trabeculation (HP:0100670)3.57361735
33Squamous cell carcinoma (HP:0002860)3.53800253
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.53162374
35Decreased activity of mitochondrial respiratory chain (HP:0008972)3.53162374
36Turricephaly (HP:0000262)3.47539661
37Popliteal pterygium (HP:0009756)3.45145446
38Breast hypoplasia (HP:0003187)3.43127221
39Delayed epiphyseal ossification (HP:0002663)3.41468236
40Macrocytic anemia (HP:0001972)3.35211829
41Cerebral hypomyelination (HP:0006808)3.32453709
42Thrombocytosis (HP:0001894)3.27832002
43Pallor (HP:0000980)3.21404682
44Aplasia of the musculature (HP:0100854)3.16883734
45Aplasia/Hypoplasia of the sacrum (HP:0008517)3.15209964
46Abnormal albumin level (HP:0012116)3.11735781
47Hypoalbuminemia (HP:0003073)3.11735781
48Hepatocellular necrosis (HP:0001404)3.09127684
49Abnormality of placental membranes (HP:0011409)3.08649232
50Amniotic constriction ring (HP:0009775)3.08649232
51Colon cancer (HP:0003003)3.08075463
52Anteriorly placed anus (HP:0001545)3.07020887
53Abnormality of renal resorption (HP:0011038)3.05927074
54Bony spicule pigmentary retinopathy (HP:0007737)2.96995690
55Trismus (HP:0000211)2.94802548
56Increased serum lactate (HP:0002151)2.92414999
57Selective tooth agenesis (HP:0001592)2.92211474
58Multiple enchondromatosis (HP:0005701)2.91443592
59Abnormal urine phosphate concentration (HP:0012599)2.89685839
60Type I transferrin isoform profile (HP:0003642)2.87988565
61Degeneration of anterior horn cells (HP:0002398)2.86120868
62Abnormality of the anterior horn cell (HP:0006802)2.86120868
63Coronal craniosynostosis (HP:0004440)2.85701799
64Decreased central vision (HP:0007663)2.83021492
65Hypophosphatemic rickets (HP:0004912)2.81706078
66Hepatic necrosis (HP:0002605)2.78972088
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76973253
68Atrioventricular block (HP:0001678)2.73015388
69Neonatal onset (HP:0003623)2.70095976
70Fetal akinesia sequence (HP:0001989)2.66690973
71Mitochondrial inheritance (HP:0001427)2.65706144
72Severe visual impairment (HP:0001141)2.62714004
73Abnormality of the costochondral junction (HP:0000919)2.62691255
74Abnormal trabecular bone morphology (HP:0100671)2.62117429
75Myotonia (HP:0002486)2.59415137
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.59303914
7711 pairs of ribs (HP:0000878)2.59258121
78Absent thumb (HP:0009777)2.59137159
79Increased CSF lactate (HP:0002490)2.57868965
80Zonular cataract (HP:0010920)2.53541400
81Pancytopenia (HP:0001876)2.53479100
82Congenital stationary night blindness (HP:0007642)2.50818675
83Patellar aplasia (HP:0006443)2.50268809
84Abnormal epiphyseal ossification (HP:0010656)2.45647280
85Increased hepatocellular lipid droplets (HP:0006565)2.45440816
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.45075914
87Agnosia (HP:0010524)2.41549345
88Abnormality of the common coagulation pathway (HP:0010990)2.40529616
89Exertional dyspnea (HP:0002875)2.38694968
90Aplasia/Hypoplasia of the patella (HP:0006498)2.36393895
91Capillary hemangiomas (HP:0005306)2.36073254
92Choanal stenosis (HP:0000452)2.32688424
93Sparse eyelashes (HP:0000653)2.32230772
94Joint stiffness (HP:0001387)2.30431795
95Cellular immunodeficiency (HP:0005374)2.29686014
96Abnormal protein glycosylation (HP:0012346)2.29663184
97Abnormal glycosylation (HP:0012345)2.29663184
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29663184
99Abnormal protein N-linked glycosylation (HP:0012347)2.29663184
100IgM deficiency (HP:0002850)2.28056943
101Poor head control (HP:0002421)2.27838359
102Premature ovarian failure (HP:0008209)2.25802656
103Chorioretinal atrophy (HP:0000533)2.25242296
104Epiphyseal stippling (HP:0010655)2.25167594
105Hyperphosphaturia (HP:0003109)2.24370635
106Enlarged epiphyses (HP:0010580)2.24060605
107Neoplasm of the pancreas (HP:0002894)2.23568551
108Premature graying of hair (HP:0002216)2.23331377
109Lipid accumulation in hepatocytes (HP:0006561)2.22606843
110Petechiae (HP:0000967)2.18766775
111Widely patent fontanelles and sutures (HP:0004492)2.18517840
112Acute necrotizing encephalopathy (HP:0006965)2.16016843
113Abnormality of the umbilical cord (HP:0010881)2.12817153
114Progressive muscle weakness (HP:0003323)2.10837712
115Flat occiput (HP:0005469)2.09973912
116Increased serum pyruvate (HP:0003542)2.08515228
117Abnormality of glycolysis (HP:0004366)2.08515228
118Reduced antithrombin III activity (HP:0001976)2.07402806
119Glossoptosis (HP:0000162)2.07135132
120Neonatal respiratory distress (HP:0002643)2.06864844
121Bowing of the arm (HP:0006488)2.05303723
122Bowed forearm bones (HP:0003956)2.05303723
123Abnormal mitochondria in muscle tissue (HP:0008316)2.05068682
124Basal cell carcinoma (HP:0002671)2.04628430
125CNS hypomyelination (HP:0003429)2.04130004
126Cholelithiasis (HP:0001081)2.04000956
127Lactic acidosis (HP:0003128)2.03579110
128Irregular epiphyses (HP:0010582)2.03256262
129Renal tubular dysfunction (HP:0000124)2.02405585
130Aplasia/Hypoplasia involving the musculature (HP:0001460)1.99005933
131Secondary amenorrhea (HP:0000869)1.98035625
132Bone marrow hypocellularity (HP:0005528)1.97693475
133Cleft eyelid (HP:0000625)1.95920023
134Poikiloderma (HP:0001029)1.95678013
135Glycosuria (HP:0003076)1.93746179
136Abnormality of urine glucose concentration (HP:0011016)1.93746179
137Short chin (HP:0000331)1.93396053
138Myopathic facies (HP:0002058)1.92925491
139Emotional lability (HP:0000712)1.92527803
140Respiratory difficulties (HP:0002880)1.92249318
141Increased intramyocellular lipid droplets (HP:0012240)1.91608667
142Horseshoe kidney (HP:0000085)1.91426779
143Lymphoma (HP:0002665)1.91366474
144Exercise intolerance (HP:0003546)1.91159663
145Short humerus (HP:0005792)1.90647920
146Absent radius (HP:0003974)1.90096040
147Thin ribs (HP:0000883)1.90017557
1483-Methylglutaconic aciduria (HP:0003535)1.89406830
149Slender long bone (HP:0003100)1.87938472
150Abnormality of reticulocytes (HP:0004312)1.86983164
151Abnormality of the preputium (HP:0100587)1.84522050
152Diminished movement (HP:0002374)1.84268863
153Aplasia/hypoplasia of the humerus (HP:0006507)1.83775447
154Meckel diverticulum (HP:0002245)1.83731724
155Respiratory failure (HP:0002878)1.81737456
156Pterygium (HP:0001059)1.80566784
157Elevated erythrocyte sedimentation rate (HP:0003565)1.79863257
158Myelodysplasia (HP:0002863)1.79676706
159Microvesicular hepatic steatosis (HP:0001414)1.79599274
160Progressive external ophthalmoplegia (HP:0000590)1.78652013
161Death in infancy (HP:0001522)1.78435247
162Megaloblastic anemia (HP:0001889)1.78299458
163Abnormal gallbladder morphology (HP:0012437)1.77154709
164Patent foramen ovale (HP:0001655)1.76832968
165Pulmonary fibrosis (HP:0002206)1.76093332
166CNS demyelination (HP:0007305)1.76042557
167Personality changes (HP:0000751)1.75919973
168Abnormality of the ileum (HP:0001549)1.75473311
169Ependymoma (HP:0002888)1.74767474
170Absent forearm bone (HP:0003953)1.73733220
171Aplasia involving forearm bones (HP:0009822)1.73733220
172Muscle fiber atrophy (HP:0100295)1.73475414
173Abnormal umbilical cord blood vessels (HP:0011403)1.73333154
174Single umbilical artery (HP:0001195)1.73333154
175Abnormality of the fetal cardiovascular system (HP:0010948)1.73333154
176Short thumb (HP:0009778)1.72968522
177Fused cervical vertebrae (HP:0002949)1.71211589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.18400543
2BUB14.96559218
3WEE13.80895950
4TESK23.23816591
5NME23.08597713
6WNK43.08594322
7EIF2AK12.85550310
8ACVR1B2.66806947
9MUSK2.59400455
10EIF2AK32.45100454
11SRPK12.33722032
12STK162.32516750
13CDC72.32433059
14PIM22.23797835
15PLK42.09279688
16BRSK22.07450791
17VRK22.07373504
18RPS6KA42.05268076
19TLK11.96152931
20SIK11.95624019
21KDR1.81987287
22TRIB31.81435959
23VRK11.78022698
24TSSK61.76511170
25NEK21.74584146
26MAP3K111.67963573
27SMG11.58982448
28PASK1.58187679
29MAP4K11.52830920
30DYRK31.52826319
31IRAK31.50682891
32TESK11.49624053
33EPHA21.46485975
34RPS6KB21.44407627
35BMX1.43594334
36CDK71.43368326
37TGFBR11.42288842
38PLK11.39882293
39BRSK11.35835439
40BCKDK1.32178861
41TTK1.31492734
42AURKA1.26093118
43STK101.24065906
44AURKB1.23972481
45NME11.22511219
46ATR1.20177523
47MAP3K81.19675404
48NEK11.18975506
49CCNB11.17670017
50IRAK21.17613970
51SIK21.15232602
52TRIM281.14000746
53MAP3K31.08371521
54MAP2K31.04853375
55ZAP701.04348387
56MST1R1.01844999
57ICK1.01679759
58PDK21.01679402
59LRRK21.00264398
60PAK40.98451340
61CDK11A0.96292388
62CHEK20.96071180
63DYRK1B0.95737072
64CDK150.95522444
65PRKD20.93918712
66BRAF0.93638321
67PBK0.90997949
68CDK190.90174450
69SCYL20.90020818
70TAOK20.89521021
71MST40.88882350
72CDK180.88518540
73CDK80.87845002
74ILK0.86743605
75CDK40.86109078
76PDPK10.85132979
77ARAF0.83309381
78MAPKAPK30.81856779
79TBK10.80096517
80FLT30.80040602
81BTK0.77738362
82BLK0.76655590
83CDK140.76423564
84PIM10.75259223
85PAK10.74725482
86LIMK10.72755789
87CSK0.72588462
88ERN10.70491441
89PLK30.69957490
90KIT0.67849542
91ZAK0.65389116
92CSNK2A10.64815048
93MAP2K20.63901215
94TYK20.63310820
95IKBKB0.63094225
96CHEK10.61862459
97TEC0.61208287
98PRPF4B0.60026950
99EIF2AK20.59451191
100STK40.58714206
101IRAK40.58087535
102MAP2K60.57929049
103RPS6KA50.56420767
104RPS6KC10.55950191
105RPS6KL10.55950191
106MAPK110.55870094
107EEF2K0.54662957
108ABL20.54485086
109CSNK2A20.54017774
110RPS6KA60.53741784
111PRKCI0.53558561
112LMTK20.53121604
113CDK60.52753410
114PRKD10.49982219
115RPS6KA20.49100284
116ADRBK10.46607193
117SIK30.46560333
118DAPK30.45875875
119NLK0.45654032
120DYRK20.44208429
121GRK60.41296235
122PRKG20.40803382
123MAP3K100.40448987
124CSF1R0.40359290
125ADRBK20.39285320
126CDK20.39192674
127MATK0.38872740
128MAPKAPK20.36330621
129CSNK1G30.36160700
130MKNK10.35469230
131IKBKE0.35336039
132DAPK10.34781852
133TAOK10.33854025
134ATM0.33206838
135MTOR0.32605569
136CLK10.32241168
137JAK30.32052842
138CHUK0.32025284
139CDK10.29861734
140AKT20.29290133
141EPHB20.27493974
142MAPK80.25626519
143PTK60.25491304
144CSNK1A1L0.24132194
145PRKCD0.23078808

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006045.32879454
2DNA replication_Homo sapiens_hsa030304.91694112
3Ribosome_Homo sapiens_hsa030104.45460461
4Proteasome_Homo sapiens_hsa030504.17915888
5Mismatch repair_Homo sapiens_hsa034304.13949463
6RNA polymerase_Homo sapiens_hsa030203.36567224
7Base excision repair_Homo sapiens_hsa034103.12866021
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03778885
9Spliceosome_Homo sapiens_hsa030402.97906191
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.75178833
11Pyrimidine metabolism_Homo sapiens_hsa002402.72478063
12Nucleotide excision repair_Homo sapiens_hsa034202.63891740
13Homologous recombination_Homo sapiens_hsa034402.57072572
14RNA transport_Homo sapiens_hsa030132.46783562
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34427772
16One carbon pool by folate_Homo sapiens_hsa006702.27202124
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11975944
18Cell cycle_Homo sapiens_hsa041102.08002552
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.01184758
20Sphingolipid metabolism_Homo sapiens_hsa006001.84780309
21Protein export_Homo sapiens_hsa030601.68247830
22Non-homologous end-joining_Homo sapiens_hsa034501.65439785
23Fanconi anemia pathway_Homo sapiens_hsa034601.60240058
24Folate biosynthesis_Homo sapiens_hsa007901.50743002
25RNA degradation_Homo sapiens_hsa030181.48441633
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47906261
27Purine metabolism_Homo sapiens_hsa002301.38992478
28Basal transcription factors_Homo sapiens_hsa030221.35371142
29p53 signaling pathway_Homo sapiens_hsa041151.30571663
30Sulfur relay system_Homo sapiens_hsa041221.27957834
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25902434
32Pentose phosphate pathway_Homo sapiens_hsa000301.25487217
33Vitamin digestion and absorption_Homo sapiens_hsa049771.21712114
34Parkinsons disease_Homo sapiens_hsa050121.17686770
35Oxidative phosphorylation_Homo sapiens_hsa001901.16412362
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07632977
37Epstein-Barr virus infection_Homo sapiens_hsa051691.07629365
38Hedgehog signaling pathway_Homo sapiens_hsa043401.02616026
39Drug metabolism - other enzymes_Homo sapiens_hsa009830.97320120
40Pyruvate metabolism_Homo sapiens_hsa006200.96104065
41Huntingtons disease_Homo sapiens_hsa050160.95570288
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.91491092
43mRNA surveillance pathway_Homo sapiens_hsa030150.88582795
44Biosynthesis of amino acids_Homo sapiens_hsa012300.85433796
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84434773
46Antigen processing and presentation_Homo sapiens_hsa046120.83429216
47Herpes simplex infection_Homo sapiens_hsa051680.81296515
48N-Glycan biosynthesis_Homo sapiens_hsa005100.79961128
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76741670
50Glutathione metabolism_Homo sapiens_hsa004800.76268079
51Other glycan degradation_Homo sapiens_hsa005110.74607478
52Selenocompound metabolism_Homo sapiens_hsa004500.74309711
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73258782
54Legionellosis_Homo sapiens_hsa051340.72877175
55Sulfur metabolism_Homo sapiens_hsa009200.70861934
56Primary immunodeficiency_Homo sapiens_hsa053400.68965282
57Shigellosis_Homo sapiens_hsa051310.68838106
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67924916
59Systemic lupus erythematosus_Homo sapiens_hsa053220.67372326
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67107743
61Galactose metabolism_Homo sapiens_hsa000520.66338393
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65867087
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65047215
64Vitamin B6 metabolism_Homo sapiens_hsa007500.63109562
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.61923351
66Carbon metabolism_Homo sapiens_hsa012000.61921504
67Viral carcinogenesis_Homo sapiens_hsa052030.61846830
68Fructose and mannose metabolism_Homo sapiens_hsa000510.58974584
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56301777
70Thyroid cancer_Homo sapiens_hsa052160.55096121
71HTLV-I infection_Homo sapiens_hsa051660.54822358
72Apoptosis_Homo sapiens_hsa042100.54052854
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50254700
74Alzheimers disease_Homo sapiens_hsa050100.48215132
75* Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46315083
76Steroid biosynthesis_Homo sapiens_hsa001000.45632276
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45286656
78Metabolic pathways_Homo sapiens_hsa011000.44709419
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44491235
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41977853
81Basal cell carcinoma_Homo sapiens_hsa052170.41900774
82Notch signaling pathway_Homo sapiens_hsa043300.41745030
83mTOR signaling pathway_Homo sapiens_hsa041500.40645778
84Measles_Homo sapiens_hsa051620.40497275
85Oocyte meiosis_Homo sapiens_hsa041140.39336145
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.38968323
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38003424
88Alcoholism_Homo sapiens_hsa050340.36654288
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36043343
90Bladder cancer_Homo sapiens_hsa052190.34239387
91Endocytosis_Homo sapiens_hsa041440.34187307
92Circadian rhythm_Homo sapiens_hsa047100.33306701
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33242587
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32546859
95Hepatitis C_Homo sapiens_hsa051600.31151707
96Arachidonic acid metabolism_Homo sapiens_hsa005900.30821261
97Hippo signaling pathway_Homo sapiens_hsa043900.30518289
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30261018
99Ovarian steroidogenesis_Homo sapiens_hsa049130.27454772
100Regulation of autophagy_Homo sapiens_hsa041400.27322616
101Acute myeloid leukemia_Homo sapiens_hsa052210.26350477
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.26342029
103Renin-angiotensin system_Homo sapiens_hsa046140.26013935
104Hematopoietic cell lineage_Homo sapiens_hsa046400.25811532
105Small cell lung cancer_Homo sapiens_hsa052220.23779989
106Inositol phosphate metabolism_Homo sapiens_hsa005620.23237577
107Chemical carcinogenesis_Homo sapiens_hsa052040.23222788
108Taste transduction_Homo sapiens_hsa047420.22404434
109VEGF signaling pathway_Homo sapiens_hsa043700.21244478
110Hepatitis B_Homo sapiens_hsa051610.21211048
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.21033950
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20230924
113Influenza A_Homo sapiens_hsa051640.19757939
114Arginine and proline metabolism_Homo sapiens_hsa003300.19102298
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18734084
116HIF-1 signaling pathway_Homo sapiens_hsa040660.18451452
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17174477
118Leishmaniasis_Homo sapiens_hsa051400.16905107
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.16551802
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.16370415
121Lysine degradation_Homo sapiens_hsa003100.15707888
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15528170
123Allograft rejection_Homo sapiens_hsa053300.13493216
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.13181004
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12542476
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11761118
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11724236
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11106687
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.10831923
130Lysosome_Homo sapiens_hsa041420.10263669
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.09616222
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.08701564
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.07615934
134Phenylalanine metabolism_Homo sapiens_hsa003600.07186655

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