RCHY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)4.69142417
2DNA double-strand break processing (GO:0000729)4.63998638
3cullin deneddylation (GO:0010388)4.57141875
4regulation of female gonad development (GO:2000194)4.30248753
5protein K6-linked ubiquitination (GO:0085020)4.13647401
6muscle organ morphogenesis (GO:0048644)4.08489362
7rRNA methylation (GO:0031167)4.03957609
8signal peptide processing (GO:0006465)4.03697522
9regulation of meiosis I (GO:0060631)3.90328190
10regulation of meiosis (GO:0040020)3.84632420
11maturation of 5.8S rRNA (GO:0000460)3.82200325
12mitotic metaphase plate congression (GO:0007080)3.70654471
13rRNA modification (GO:0000154)3.65968261
14regulation of DNA methylation (GO:0044030)3.57766407
15regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.56819085
16regulation of mitotic spindle checkpoint (GO:1903504)3.56819085
17attachment of spindle microtubules to kinetochore (GO:0008608)3.54514156
18centriole replication (GO:0007099)3.53310351
19CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.52879329
20RNA capping (GO:0036260)3.51948799
217-methylguanosine RNA capping (GO:0009452)3.51948799
22T cell lineage commitment (GO:0002360)3.48549223
23regulation of histone H3-K27 methylation (GO:0061085)3.48500494
24regulation of RIG-I signaling pathway (GO:0039535)3.46782074
25proteasome assembly (GO:0043248)3.43315046
26histone exchange (GO:0043486)3.40549031
277-methylguanosine mRNA capping (GO:0006370)3.39832083
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.39388044
29chaperone-mediated protein transport (GO:0072321)3.39177150
30IMP biosynthetic process (GO:0006188)3.36104533
31water-soluble vitamin biosynthetic process (GO:0042364)3.31990814
32centriole assembly (GO:0098534)3.31254458
33DNA damage response, detection of DNA damage (GO:0042769)3.28722862
34oocyte maturation (GO:0001556)3.27066192
35negative regulation of DNA recombination (GO:0045910)3.26213749
36histone mRNA metabolic process (GO:0008334)3.24180642
37synapsis (GO:0007129)3.23563192
38replication fork processing (GO:0031297)3.20104024
39regulation of meiotic cell cycle (GO:0051445)3.18515186
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.18378372
41regulation of helicase activity (GO:0051095)3.17966933
42RNA destabilization (GO:0050779)3.17020240
43negative regulation of execution phase of apoptosis (GO:1900118)3.16175089
44negative regulation of meiosis (GO:0045835)3.14999731
45myoblast migration (GO:0051451)3.14706773
46female gamete generation (GO:0007292)3.13685616
47meiotic cell cycle (GO:0051321)3.12675480
48RNA methylation (GO:0001510)3.11703298
49DNA ligation (GO:0006266)3.10199728
50purine nucleobase biosynthetic process (GO:0009113)3.09511947
51positive regulation of mitochondrial fission (GO:0090141)3.09366160
52negative regulation of type 2 immune response (GO:0002829)3.08086506
53regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.07301937
54metaphase plate congression (GO:0051310)3.05365102
55mitochondrial respiratory chain complex assembly (GO:0033108)3.05038060
56DNA catabolic process, exonucleolytic (GO:0000738)3.03916130
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02464016
58piRNA metabolic process (GO:0034587)3.00516279
59histone H2A acetylation (GO:0043968)2.99705117
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99682464
61respiratory chain complex IV assembly (GO:0008535)2.98139513
62glycerophospholipid catabolic process (GO:0046475)2.97666116
63somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.97084535
64isotype switching (GO:0045190)2.97084535
65somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.97084535
66ubiquinone biosynthetic process (GO:0006744)2.95968570
67quinone biosynthetic process (GO:1901663)2.95968570
68double-strand break repair via nonhomologous end joining (GO:0006303)2.95834054
69non-recombinational repair (GO:0000726)2.95834054
70DNA replication-independent nucleosome assembly (GO:0006336)2.95089268
71DNA replication-independent nucleosome organization (GO:0034724)2.95089268
72cytochrome complex assembly (GO:0017004)2.93871202
73protein complex biogenesis (GO:0070271)2.93228414
74positive regulation of defense response to virus by host (GO:0002230)2.92865553
75intraciliary transport (GO:0042073)2.91595242
76lactate metabolic process (GO:0006089)2.91420757
77DNA replication checkpoint (GO:0000076)2.91062355
78positive regulation of granulocyte differentiation (GO:0030854)2.90893532
79DNA methylation involved in gamete generation (GO:0043046)2.89710040
80DNA replication-dependent nucleosome organization (GO:0034723)2.89309235
81DNA replication-dependent nucleosome assembly (GO:0006335)2.89309235
82IMP metabolic process (GO:0046040)2.88722590
83transcription elongation from RNA polymerase II promoter (GO:0006368)2.87833946
84mitochondrial respiratory chain complex I assembly (GO:0032981)2.86874578
85NADH dehydrogenase complex assembly (GO:0010257)2.86874578
86mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86874578
87protein K48-linked ubiquitination (GO:0070936)2.86835319
88DNA damage response, signal transduction resulting in transcription (GO:0042772)2.84268915
89ribosome assembly (GO:0042255)2.82396235
90resolution of meiotic recombination intermediates (GO:0000712)2.82292210
91termination of RNA polymerase III transcription (GO:0006386)2.82241142
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.82241142
93negative regulation of DNA-templated transcription, elongation (GO:0032785)2.80578590
94negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.80578590
95protein K11-linked ubiquitination (GO:0070979)2.80144930
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.79495600
97poly(A)+ mRNA export from nucleus (GO:0016973)2.79092213
98protein deneddylation (GO:0000338)2.78463932
99establishment of chromosome localization (GO:0051303)2.77975893
100positive regulation of DNA recombination (GO:0045911)2.77856048
101response to X-ray (GO:0010165)2.75731056
102platelet dense granule organization (GO:0060155)2.75475901
103mitotic spindle checkpoint (GO:0071174)2.74629889
104motile cilium assembly (GO:0044458)2.74128804
105negative regulation of mitotic sister chromatid segregation (GO:0033048)2.73912786
106negative regulation of mitotic sister chromatid separation (GO:2000816)2.73912786
107negative regulation of sister chromatid segregation (GO:0033046)2.73912786
108negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.73912786
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.73912786
110female gonad development (GO:0008585)2.73312188
111CENP-A containing nucleosome assembly (GO:0034080)2.72445576
112single strand break repair (GO:0000012)2.72335395
113organelle disassembly (GO:1903008)2.72053448
114male meiosis (GO:0007140)2.71392157
115deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70826240
116spindle checkpoint (GO:0031577)2.68981570
117mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.68216903
118negative regulation of transcription by competitive promoter binding (GO:0010944)2.67948353
119somatic hypermutation of immunoglobulin genes (GO:0016446)2.67588513
120somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67588513
121meiotic chromosome segregation (GO:0045132)2.66753242
122mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65795011
123negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.64643816
124negative regulation of ligase activity (GO:0051352)2.64643816
125ubiquinone metabolic process (GO:0006743)2.64461613
126establishment of integrated proviral latency (GO:0075713)2.63588770
127recombinational repair (GO:0000725)2.63485923
128peptidyl-histidine modification (GO:0018202)2.62878304
129regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.62373710
130double-strand break repair via homologous recombination (GO:0000724)2.62147460
131postreplication repair (GO:0006301)2.61761930
132tRNA methylation (GO:0030488)2.61205132
133negative regulation of meiotic cell cycle (GO:0051447)2.60219876
134regulation of acyl-CoA biosynthetic process (GO:0050812)2.60045608
135anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.59695451
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59614442
137positive regulation of Cdc42 GTPase activity (GO:0043089)2.59575116
138pseudouridine synthesis (GO:0001522)2.59026590
139N-terminal protein amino acid acetylation (GO:0006474)2.58808041
140negative regulation of chromosome segregation (GO:0051985)2.58521119
141type B pancreatic cell development (GO:0003323)2.58370745
142maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.57334052
143mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.56792777
144positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.56792777
145nucleobase biosynthetic process (GO:0046112)2.56081045
146DNA-templated transcription, elongation (GO:0006354)2.55795804
147termination of RNA polymerase I transcription (GO:0006363)2.55555389
148regulation of cellular amino acid metabolic process (GO:0006521)2.54977432
149regulation of isotype switching to IgG isotypes (GO:0048302)2.54855878
150polyketide metabolic process (GO:0030638)2.54553322
151doxorubicin metabolic process (GO:0044598)2.54553322
152daunorubicin metabolic process (GO:0044597)2.54553322
153regulation of mitotic metaphase/anaphase transition (GO:0030071)2.54224965
154regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.54224965
155protein-cofactor linkage (GO:0018065)2.54120912
156mitochondrial RNA metabolic process (GO:0000959)2.54034270
157mismatch repair (GO:0006298)2.53478259
158chromatin remodeling at centromere (GO:0031055)2.53309420
159dopamine transport (GO:0015872)2.52586719
160protein localization to mitochondrion (GO:0070585)2.52518182
161ribonucleoprotein complex disassembly (GO:0032988)2.50530446
162phospholipid scrambling (GO:0017121)2.50211103
163positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.50176442
164transcription from RNA polymerase I promoter (GO:0006360)2.48117022
165DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.47291461
166RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.45315802
167transcription elongation from RNA polymerase I promoter (GO:0006362)2.45016503
168exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43994351
169regulation of glucocorticoid metabolic process (GO:0031943)2.43906621
170male meiosis I (GO:0007141)2.43241681
171pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.43171815
172cellular protein catabolic process (GO:0044257)2.40179539
173negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.39730159
174endosome to melanosome transport (GO:0035646)2.39033866
175endosome to pigment granule transport (GO:0043485)2.39033866
176axonemal dynein complex assembly (GO:0070286)2.38543710
177GDP-mannose metabolic process (GO:0019673)2.38478049
178GPI anchor biosynthetic process (GO:0006506)2.37169066
179NIK/NF-kappaB signaling (GO:0038061)2.36839194
180positive regulation of isotype switching (GO:0045830)2.36574969
181transcription initiation from RNA polymerase I promoter (GO:0006361)2.36485477
182preassembly of GPI anchor in ER membrane (GO:0016254)2.36191942
183nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.36100746

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.57174549
2* GABP_17652178_ChIP-ChIP_JURKAT_Human3.37929228
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26018292
4ZNF274_21170338_ChIP-Seq_K562_Hela2.70692744
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68552706
6KAP1_22055183_ChIP-Seq_ESCs_Mouse2.63797106
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.63423839
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.58584602
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52170178
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.51863054
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.36554835
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.33715619
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.32564520
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30769333
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.27832576
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.21274018
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19876490
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.16277864
19VDR_23849224_ChIP-Seq_CD4+_Human2.11822618
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08371125
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05436315
22FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05314472
23GBX2_23144817_ChIP-Seq_PC3_Human2.02135118
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01063277
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97539952
26P300_19829295_ChIP-Seq_ESCs_Human1.96741338
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84975518
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.83153144
29IRF1_19129219_ChIP-ChIP_H3396_Human1.80607870
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80587910
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77243979
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77084015
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76518409
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.75799370
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74544134
36ELK1_19687146_ChIP-ChIP_HELA_Human1.74026033
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72671311
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70789593
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70068942
40E2F7_22180533_ChIP-Seq_HELA_Human1.67016010
41DCP1A_22483619_ChIP-Seq_HELA_Human1.64597670
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62855978
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62822593
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57690326
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57080015
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.56718092
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56462855
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54829949
49* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52391294
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51627232
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.51391688
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51015179
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.49422049
54FOXP3_21729870_ChIP-Seq_TREG_Human1.47695453
55MYC_18940864_ChIP-ChIP_HL60_Human1.46356670
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46136643
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45600872
58IGF1R_20145208_ChIP-Seq_DFB_Human1.44251247
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42605562
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42197112
61VDR_22108803_ChIP-Seq_LS180_Human1.41546879
62NMYC_18555785_Chip-Seq_ESCs_Mouse1.38457630
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38378679
64* IRF8_21731497_ChIP-ChIP_J774_Mouse1.38019992
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.37891682
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37810478
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.35843923
68LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34783810
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34365995
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33027974
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31104790
72ER_23166858_ChIP-Seq_MCF-7_Human1.30778073
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30517577
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29272649
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.29271844
76* GABP_19822575_ChIP-Seq_HepG2_Human1.27442782
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26541778
78CBP_20019798_ChIP-Seq_JUKART_Human1.26541778
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25218963
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25051663
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21454103
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21214465
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.21167847
84FUS_26573619_Chip-Seq_HEK293_Human1.20477726
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19398641
86* SMAD4_21799915_ChIP-Seq_A2780_Human1.18620853
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.16895550
88EWS_26573619_Chip-Seq_HEK293_Human1.16727268
89ZFX_18555785_Chip-Seq_ESCs_Mouse1.16127809
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15112144
91KLF4_18555785_Chip-Seq_ESCs_Mouse1.15057532
92NANOG_19829295_ChIP-Seq_ESCs_Human1.15051678
93SOX2_19829295_ChIP-Seq_ESCs_Human1.15051678
94TAF15_26573619_Chip-Seq_HEK293_Human1.14811545
95NANOG_16153702_ChIP-ChIP_HESCs_Human1.14655166
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.14457731
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.14426366
98* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13761826
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13372790
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12417473
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12400785
102HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11914989
103P53_22387025_ChIP-Seq_ESCs_Mouse1.11211964
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10858954
105TCF4_22108803_ChIP-Seq_LS180_Human1.10338081
106TP53_22573176_ChIP-Seq_HFKS_Human1.09650577
107SPI1_23547873_ChIP-Seq_NB4_Human1.09275324
108OCT4_18555785_Chip-Seq_ESCs_Mouse1.09107844
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08939046
110SOX2_18555785_Chip-Seq_ESCs_Mouse1.08690753
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.07420569
112HTT_18923047_ChIP-ChIP_STHdh_Human1.07319561
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06725864
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05875238
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05851006
116NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05751916
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05475096
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05225012
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04908266
120* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04392428
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03433800
122RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02632811
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02011437
124STAT3_23295773_ChIP-Seq_U87_Human1.01988456
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01124192
126YY1_21170310_ChIP-Seq_MESCs_Mouse1.01004245
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.00724327
128BCAT_22108803_ChIP-Seq_LS180_Human1.00469558
129GATA3_26560356_Chip-Seq_TH2_Human1.00380299
130OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00344651
131FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99943327
132FOXA1_25329375_ChIP-Seq_VCAP_Human0.99943327
133MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99518528
134MYC_18555785_ChIP-Seq_MESCs_Mouse0.97925285
135SOX2_16153702_ChIP-ChIP_HESCs_Human0.97805394
136MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97803585
137E2F1_18555785_Chip-Seq_ESCs_Mouse0.97060226
138RNF2_27304074_Chip-Seq_NSC_Mouse0.96102085
139POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95853510
140ERG_20517297_ChIP-Seq_VCAP_Human0.95722811
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95695046
142STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95676645
143ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95395098
144P300_18555785_Chip-Seq_ESCs_Mouse0.95312096
145ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94482970
146STAT1_17558387_ChIP-Seq_HELA_Human0.94024536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.80461392
2MP0005451_abnormal_body_composition3.71929478
3MP0003718_maternal_effect3.32332199
4MP0002102_abnormal_ear_morphology3.32045045
5MP0005310_abnormal_salivary_gland3.20859806
6MP0003693_abnormal_embryo_hatching3.05568944
7MP0004510_myositis2.68099338
8MP0000566_synostosis2.56169286
9MP0008057_abnormal_DNA_replication2.48441039
10MP0002132_abnormal_respiratory_system2.33228688
11MP0003890_abnormal_embryonic-extraembry2.20692265
12MP0005671_abnormal_response_to2.12563499
13MP0003880_abnormal_central_pattern2.10505063
14MP0002277_abnormal_respiratory_mucosa2.08800873
15MP0003121_genomic_imprinting2.07366416
16MP0010386_abnormal_urinary_bladder2.06357860
17MP0008877_abnormal_DNA_methylation2.02916411
18MP0002693_abnormal_pancreas_physiology1.99386258
19MP0003763_abnormal_thymus_physiology1.99319460
20MP0001529_abnormal_vocalization1.94838109
21MP0008260_abnormal_autophagy1.94780109
22MP0005379_endocrine/exocrine_gland_phen1.91733004
23MP0005084_abnormal_gallbladder_morpholo1.88129097
24MP0004215_abnormal_myocardial_fiber1.86400739
25MP0003122_maternal_imprinting1.86386574
26MP0006035_abnormal_mitochondrial_morpho1.86306935
27MP0000372_irregular_coat_pigmentation1.85177521
28MP0005408_hypopigmentation1.82457622
29MP0001986_abnormal_taste_sensitivity1.81400960
30MP0002163_abnormal_gland_morphology1.79874539
31MP0005220_abnormal_exocrine_pancreas1.77919782
32MP0001835_abnormal_antigen_presentation1.77538141
33MP0005253_abnormal_eye_physiology1.76258627
34MP0006276_abnormal_autonomic_nervous1.71368692
35MP0006036_abnormal_mitochondrial_physio1.70138658
36MP0003195_calcinosis1.69302180
37MP0002736_abnormal_nociception_after1.69101931
38MP0009785_altered_susceptibility_to1.64674702
39MP0001984_abnormal_olfaction1.62760581
40MP0001119_abnormal_female_reproductive1.62309261
41MP0004957_abnormal_blastocyst_morpholog1.60097555
42MP0001188_hyperpigmentation1.57909561
43MP0002837_dystrophic_cardiac_calcinosis1.57055527
44MP0001873_stomach_inflammation1.55145607
45MP0000613_abnormal_salivary_gland1.52786040
46MP0002638_abnormal_pupillary_reflex1.51754106
47MP0004147_increased_porphyrin_level1.51578436
48MP0001919_abnormal_reproductive_system1.51088842
49MP0003011_delayed_dark_adaptation1.50625075
50MP0009333_abnormal_splenocyte_physiolog1.48480405
51MP0003567_abnormal_fetal_cardiomyocyte1.47360088
52MP0008058_abnormal_DNA_repair1.46063241
53MP0006072_abnormal_retinal_apoptosis1.44676864
54MP0005551_abnormal_eye_electrophysiolog1.43185861
55MP0008932_abnormal_embryonic_tissue1.42939207
56MP0000678_abnormal_parathyroid_gland1.41554436
57MP0000490_abnormal_crypts_of1.40962183
58MP0009046_muscle_twitch1.40862609
59MP0009697_abnormal_copulation1.39909632
60MP0002876_abnormal_thyroid_physiology1.38153327
61MP0001944_abnormal_pancreas_morphology1.38100351
62MP0003221_abnormal_cardiomyocyte_apopto1.36199395
63MP0005000_abnormal_immune_tolerance1.34157365
64MP0002138_abnormal_hepatobiliary_system1.33961250
65MP0001346_abnormal_lacrimal_gland1.33031306
66MP0001800_abnormal_humoral_immune1.31342805
67MP0001293_anophthalmia1.30349952
68MP0004133_heterotaxia1.28188284
69MP0000015_abnormal_ear_pigmentation1.28057207
70MP0005387_immune_system_phenotype1.27678914
71MP0001790_abnormal_immune_system1.27678914
72MP0005174_abnormal_tail_pigmentation1.26893888
73MP0002405_respiratory_system_inflammati1.25338191
74MP0006054_spinal_hemorrhage1.25123178
75MP0002090_abnormal_vision1.23287717
76MP0001968_abnormal_touch/_nociception1.23177470
77MP0002877_abnormal_melanocyte_morpholog1.22612227
78MP0005395_other_phenotype1.21071059
79MP0002723_abnormal_immune_serum1.20296054
80MP0002751_abnormal_autonomic_nervous1.20256568
81MP0005499_abnormal_olfactory_system1.20254523
82MP0005394_taste/olfaction_phenotype1.20254523
83MP0008789_abnormal_olfactory_epithelium1.18325778
84MP0002254_reproductive_system_inflammat1.18193019
85MP0001929_abnormal_gametogenesis1.17459901
86MP0003786_premature_aging1.16865234
87MP0010094_abnormal_chromosome_stability1.16813273
88MP0003077_abnormal_cell_cycle1.16489844
89MP0002148_abnormal_hypersensitivity_rea1.15338697
90MP0002420_abnormal_adaptive_immunity1.14897153
91MP0001486_abnormal_startle_reflex1.13990472
92MP0003111_abnormal_nucleus_morphology1.13867869
93MP0002452_abnormal_antigen_presenting1.13517128
94MP0001485_abnormal_pinna_reflex1.13312889
95MP0001905_abnormal_dopamine_level1.13237138
96MP0001819_abnormal_immune_cell1.12619539
97MP0002210_abnormal_sex_determination1.12309255
98MP0003699_abnormal_female_reproductive1.09787956
99MP0005075_abnormal_melanosome_morpholog1.09399268
100MP0003724_increased_susceptibility_to1.09355214
101MP0000653_abnormal_sex_gland1.09244750
102MP0000681_abnormal_thyroid_gland1.07772199
103MP0001764_abnormal_homeostasis1.07581419
104MP0004142_abnormal_muscle_tone1.06948617
105MP0002398_abnormal_bone_marrow1.06789731
106MP0006082_CNS_inflammation1.05998577
107MP0008872_abnormal_physiological_respon1.05585711
108MP0005645_abnormal_hypothalamus_physiol1.05387274
109MP0002938_white_spotting1.04386690
110MP0000631_abnormal_neuroendocrine_gland1.03988011
111MP0004484_altered_response_of1.02376231
112MP0003941_abnormal_skin_development1.01710445
113MP0002160_abnormal_reproductive_system1.01682996
114MP0003119_abnormal_digestive_system1.00495736
115MP0005389_reproductive_system_phenotype1.00043586
116MP0008007_abnormal_cellular_replicative0.99840764
117MP0000647_abnormal_sebaceous_gland0.99511689
118MP0000716_abnormal_immune_system0.99470767
119MP0009745_abnormal_behavioral_response0.99400850
120MP0003646_muscle_fatigue0.95324191
121MP0005646_abnormal_pituitary_gland0.95109886
122MP0000689_abnormal_spleen_morphology0.95023395
123MP0003937_abnormal_limbs/digits/tail_de0.94690947
124MP0001851_eye_inflammation0.94669482
125MP0002272_abnormal_nervous_system0.94546847
126MP0000427_abnormal_hair_cycle0.94421554
127MP0003698_abnormal_male_reproductive0.92773766
128MP0003136_yellow_coat_color0.91503475
129MP0005025_abnormal_response_to0.91101686
130MP0002233_abnormal_nose_morphology0.90363680
131MP0002095_abnormal_skin_pigmentation0.90251204
132MP0001324_abnormal_eye_pigmentation0.89168698
133MP0000465_gastrointestinal_hemorrhage0.88306054
134MP0003137_abnormal_impulse_conducting0.88275656
135MP0000685_abnormal_immune_system0.87980723
136MP0004270_analgesia0.87678100
137MP0002653_abnormal_ependyma_morphology0.87656384
138MP0000516_abnormal_urinary_system0.87090090
139MP0005367_renal/urinary_system_phenotyp0.87090090
140MP0008995_early_reproductive_senescence0.86974910
141MP0001845_abnormal_inflammatory_respons0.84998277
142MP0002249_abnormal_larynx_morphology0.84107114
143MP0002177_abnormal_outer_ear0.83893169
144MP0004085_abnormal_heartbeat0.83798241
145MP0001502_abnormal_circadian_rhythm0.83050885
146MP0003123_paternal_imprinting0.80537497
147MP0002722_abnormal_immune_system0.79671108
148MP0004084_abnormal_cardiac_muscle0.79579595
149MP0003787_abnormal_imprinting0.79389925
150MP0001348_abnormal_lacrimal_gland0.78622053
151MP0002419_abnormal_innate_immunity0.78338764
152MP0001145_abnormal_male_reproductive0.77368070
153MP0002429_abnormal_blood_cell0.76750293
154MP0005187_abnormal_penis_morphology0.76613895
155MP0003186_abnormal_redox_activity0.75871329
156MP0000462_abnormal_digestive_system0.75585553
157MP0002734_abnormal_mechanical_nocicepti0.75055609
158MP0010155_abnormal_intestine_physiology0.74762004
159MP0002009_preneoplasia0.74383862
160MP0000358_abnormal_cell_content/0.73842589
161MP0009703_decreased_birth_body0.73695115
162MP0001286_abnormal_eye_development0.73197690
163MP0005391_vision/eye_phenotype0.72800912
164MP0000703_abnormal_thymus_morphology0.72731512
165MP0001177_atelectasis0.72128405
166MP0002084_abnormal_developmental_patter0.68409130
167MP0002234_abnormal_pharynx_morphology0.67916219
168MP0005248_abnormal_Harderian_gland0.66965540
169MP0001697_abnormal_embryo_size0.66542306

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.60158842
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.23726285
3Abnormality of alanine metabolism (HP:0010916)3.23726285
4Hyperalaninemia (HP:0003348)3.23726285
5Birth length less than 3rd percentile (HP:0003561)3.22932709
6Methylmalonic acidemia (HP:0002912)3.21400974
7Type 2 muscle fiber atrophy (HP:0003554)3.20832652
8Pancreatic fibrosis (HP:0100732)3.13200059
9Acute necrotizing encephalopathy (HP:0006965)2.95155300
10Retrobulbar optic neuritis (HP:0100654)2.93109229
11Optic neuritis (HP:0100653)2.93109229
12True hermaphroditism (HP:0010459)2.90268291
13Breast hypoplasia (HP:0003187)2.87612517
14Progressive macrocephaly (HP:0004481)2.85550058
15Acute encephalopathy (HP:0006846)2.83885055
16Dynein arm defect of respiratory motile cilia (HP:0012255)2.81557116
17Absent/shortened dynein arms (HP:0200106)2.81557116
18Nonprogressive disorder (HP:0003680)2.76838451
19Medial flaring of the eyebrow (HP:0010747)2.73942498
20Muscle fiber atrophy (HP:0100295)2.72959728
21Type I transferrin isoform profile (HP:0003642)2.71823531
22Pancreatic cysts (HP:0001737)2.70655876
23Colon cancer (HP:0003003)2.64206889
24Increased CSF lactate (HP:0002490)2.62262166
25Aplastic anemia (HP:0001915)2.61770390
26Mitochondrial inheritance (HP:0001427)2.54936468
27Lip pit (HP:0100267)2.53108760
28Methylmalonic aciduria (HP:0012120)2.52891855
29Male infertility (HP:0003251)2.51430732
30Hypoplasia of the uterus (HP:0000013)2.51254132
31Volvulus (HP:0002580)2.50267480
32Aplasia/Hypoplasia of the fovea (HP:0008060)2.48497626
33Hypoplasia of the fovea (HP:0007750)2.48497626
34Hypergonadotropic hypogonadism (HP:0000815)2.47232892
35Abnormal mitochondria in muscle tissue (HP:0008316)2.45483768
36Adrenal hypoplasia (HP:0000835)2.45336262
37Orchitis (HP:0100796)2.45175302
38Hyperglycinemia (HP:0002154)2.41906525
39Capillary hemangiomas (HP:0005306)2.41150904
40Aplasia/hypoplasia of the uterus (HP:0008684)2.39622771
41Abnormality of the fovea (HP:0000493)2.36942044
42Exertional dyspnea (HP:0002875)2.36612611
43Spondylolisthesis (HP:0003302)2.35271578
44Reduced antithrombin III activity (HP:0001976)2.32056435
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.31012353
46Hypothermia (HP:0002045)2.30558064
47Myositis (HP:0100614)2.26549099
48Pancreatic islet-cell hyperplasia (HP:0004510)2.26019959
49Congenital sensorineural hearing impairment (HP:0008527)2.24570752
50Flat capital femoral epiphysis (HP:0003370)2.23470991
51Abnormality of serum amino acid levels (HP:0003112)2.23311624
52Patellar aplasia (HP:0006443)2.23089517
53Abnormal respiratory motile cilium physiology (HP:0012261)2.21842783
54Congenital primary aphakia (HP:0007707)2.19514437
55Chronic hepatic failure (HP:0100626)2.18121914
56Intestinal atresia (HP:0011100)2.17895010
57Abnormal protein glycosylation (HP:0012346)2.17569203
58Abnormal glycosylation (HP:0012345)2.17569203
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17569203
60Abnormal protein N-linked glycosylation (HP:0012347)2.17569203
61Nephrogenic diabetes insipidus (HP:0009806)2.17442956
62Aplasia/Hypoplasia of the patella (HP:0006498)2.16642896
63Abnormality of vitamin B metabolism (HP:0004340)2.16573152
64Abnormal ciliary motility (HP:0012262)2.16438783
65Hepatocellular necrosis (HP:0001404)2.16149377
66Metaphyseal dysplasia (HP:0100255)2.16125590
67Abnormality of methionine metabolism (HP:0010901)2.15134406
68Increased hepatocellular lipid droplets (HP:0006565)2.13813360
69Short tibia (HP:0005736)2.12966800
70Chromsome breakage (HP:0040012)2.12944904
71Hepatic necrosis (HP:0002605)2.12754025
72Genital tract atresia (HP:0001827)2.12525891
73Renal Fanconi syndrome (HP:0001994)2.11492286
74Hyperinsulinemic hypoglycemia (HP:0000825)2.10454266
75Abnormality of the preputium (HP:0100587)2.09767618
76Biliary tract neoplasm (HP:0100574)2.09169407
77Abnormality of the vitamin B12 metabolism (HP:0004341)2.08511490
78Hypoglycemic coma (HP:0001325)2.08390110
79Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08176360
80Gait imbalance (HP:0002141)2.05535893
81Nasal polyposis (HP:0100582)2.05019855
82Bile duct proliferation (HP:0001408)2.04822846
83Abnormal biliary tract physiology (HP:0012439)2.04822846
84Meckel diverticulum (HP:0002245)2.02176468
85Chronic bronchitis (HP:0004469)2.02044901
86Renal cortical cysts (HP:0000803)2.01886581
87Abolished electroretinogram (ERG) (HP:0000550)2.01238622
88Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.00510532
89Generalized aminoaciduria (HP:0002909)2.00311559
90Abnormal respiratory epithelium morphology (HP:0012253)1.97488432
91Abnormal respiratory motile cilium morphology (HP:0005938)1.97488432
92Vaginal atresia (HP:0000148)1.97437641
93Abnormality of the heme biosynthetic pathway (HP:0010472)1.97016880
94Progressive neurologic deterioration (HP:0002344)1.96883524
95Progressive inability to walk (HP:0002505)1.96215904
96Abnormality of the phalanges of the 2nd finger (HP:0009541)1.95647704
97Male pseudohermaphroditism (HP:0000037)1.95580537
983-Methylglutaconic aciduria (HP:0003535)1.95560041
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95376009
100Pulmonary fibrosis (HP:0002206)1.94298872
101Abnormality of the ileum (HP:0001549)1.94129308
102Cerebral edema (HP:0002181)1.93909798
103Supernumerary spleens (HP:0009799)1.93487296
104Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93395645
105Abnormality of chromosome stability (HP:0003220)1.93206611
106Dyschromatopsia (HP:0007641)1.92015113
107Short middle phalanx of the 5th finger (HP:0004220)1.91541468
108Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90963394
109Abnormality of glycine metabolism (HP:0010895)1.90961680
110Abnormality of serine family amino acid metabolism (HP:0010894)1.90961680
111Bronchiectasis (HP:0002110)1.89978970
112Aplasia/Hypoplasia of the uvula (HP:0010293)1.88711982
113Increased serum lactate (HP:0002151)1.88053601
114Abnormal hair whorl (HP:0010721)1.87769305
115Sloping forehead (HP:0000340)1.86691089
116Limb dystonia (HP:0002451)1.84413393
117Recurrent abscess formation (HP:0002722)1.84407773
118Neoplasm of the adrenal gland (HP:0100631)1.84161633
119Hypoplastic iliac wings (HP:0002866)1.83751430
120Lipid accumulation in hepatocytes (HP:0006561)1.83352740
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.83071105
122Abnormality of the renal medulla (HP:0100957)1.82679933
123Keratoconjunctivitis sicca (HP:0001097)1.82076555
124Encephalitis (HP:0002383)1.82028199
125Clubbing of toes (HP:0100760)1.81729133
126Abnormal lung lobation (HP:0002101)1.81122881
127Hypoplastic pelvis (HP:0008839)1.80874188
128Poor coordination (HP:0002370)1.80500465
129Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.80424450
130Abnormality of midbrain morphology (HP:0002418)1.79549761
131Molar tooth sign on MRI (HP:0002419)1.79549761
132Lactic acidosis (HP:0003128)1.79489780
133Postnatal microcephaly (HP:0005484)1.78003196
134Postaxial foot polydactyly (HP:0001830)1.76840510
135Gonadotropin excess (HP:0000837)1.76728392
136Respiratory difficulties (HP:0002880)1.76326922
137Facial hemangioma (HP:0000329)1.75595982
138Bone marrow hypocellularity (HP:0005528)1.75527919
139Bifid tongue (HP:0010297)1.75257203
140Medulloblastoma (HP:0002885)1.75078509
141Abnormality of renal resorption (HP:0011038)1.74818240
142Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74752671
143Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74194670
144Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74194670
145Hypoglycemic seizures (HP:0002173)1.74113718
146Keratoconjunctivitis (HP:0001096)1.73602883
147Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.72426338
148Nephronophthisis (HP:0000090)1.71319936
149Ependymoma (HP:0002888)1.71231001
150Neoplasm of the small intestine (HP:0100833)1.71035152
151Inability to walk (HP:0002540)1.70812329
152Exercise-induced muscle cramps (HP:0003710)1.70260048
153Petechiae (HP:0000967)1.68896025
154Acute myeloid leukemia (HP:0004808)1.68474343
155Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68419181
156Decreased circulating renin level (HP:0003351)1.67722620
157Myelodysplasia (HP:0002863)1.67537051
158Recurrent bacterial skin infections (HP:0005406)1.66647109
159Premature graying of hair (HP:0002216)1.66578623
160Hyperglycinuria (HP:0003108)1.66549909
161Tubulointerstitial nephritis (HP:0001970)1.65725875
162Rhabdomyosarcoma (HP:0002859)1.65721513
163Congenital, generalized hypertrichosis (HP:0004540)1.65368043
164Pancytopenia (HP:0001876)1.65275455
165Optic disc pallor (HP:0000543)1.64873054
166Abnormality of the metopic suture (HP:0005556)1.64673588
167Hypomagnesemia (HP:0002917)1.64633787
168Postaxial hand polydactyly (HP:0001162)1.64330797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK3.94900579
2TRIM283.84814038
3BMPR23.22129951
4WNK33.19118985
5PLK42.76530388
6MKNK22.55066109
7TAOK32.54554469
8MAP3K132.48557484
9STK162.40632503
10TXK2.28370566
11NLK2.25822616
12MOS2.25389924
13BCR2.13057252
14ARAF2.10530417
15BRAF2.04215829
16ERBB32.01127020
17PLK31.99358192
18IRAK31.98125685
19NEK91.91320582
20BUB11.90987276
21MAP4K21.89756145
22BLK1.86737803
23DYRK21.81421802
24TSSK61.81153519
25MAP3K41.76614199
26BMPR1B1.69613021
27CDK81.68289251
28IRAK41.67976855
29STK38L1.62896692
30NEK11.62484282
31MAP3K61.59855021
32TEC1.50891879
33CSNK1G21.44360799
34ERBB41.42950724
35MAPK151.39123634
36JAK31.38791409
37MAP3K141.33811653
38MKNK11.33688242
39PLK21.32558056
40CHUK1.32021005
41NME21.26443902
42ACVR1B1.21850978
43RAF11.21528332
44DYRK31.21161375
45PBK1.20386847
46INSRR1.20245461
47IKBKE1.15331175
48WEE11.13884779
49BRSK21.13309875
50TTK1.09855663
51IKBKB1.09411690
52HIPK21.08583431
53MAPKAPK51.05247037
54RPS6KA41.03827337
55VRK21.03072762
56CDK31.01581890
57PNCK0.98231337
58OXSR10.97841570
59EIF2AK30.97428924
60CSNK1G10.93956510
61MAP4K10.93383018
62TNIK0.92929589
63PDK20.92852808
64TAF10.92540236
65ADRBK20.91778811
66MST40.91035776
67MAP3K120.90976073
68OBSCN0.90682399
69FRK0.90667056
70SIK30.90652598
71IRAK10.89238371
72RPS6KA50.86817939
73EPHA30.83757191
74MAPK130.81911042
75PINK10.79368502
76YES10.77431297
77CDK190.74657411
78PAK30.73175345
79MINK10.72492197
80NEK60.72082323
81ZAP700.71935807
82VRK10.71673057
83PRKCE0.69309748
84ATR0.68865134
85CHEK20.68531169
86CASK0.66375815
87TYK20.66350210
88LATS10.65826815
89ABL20.64602255
90MAP2K70.64148101
91EIF2AK20.63891073
92GRK10.63582734
93PRKD20.62471189
94MAP3K50.62411560
95BRD40.62315162
96MELK0.61118993
97FER0.60601731
98PLK10.59968351
99PRKCG0.59760118
100CSNK1G30.59326092
101ATM0.59140699
102MAPKAPK30.59137741
103GRK70.58884500
104NUAK10.58290847
105MAP2K20.56820740
106CCNB10.56382037
107SRPK10.56097258
108CSNK1A1L0.55645040
109MAP2K40.54565555
110NME10.54308404
111SGK20.53828527
112KSR20.53765161
113EPHA40.52730091
114PIM10.52714259
115CDK70.52271264
116EIF2AK10.51170219
117ZAK0.50896341
118TGFBR10.46862362
119PHKG10.46825739
120PHKG20.46825739
121STK240.46651848
122STK390.45703446
123PIK3CA0.44058240
124DYRK1A0.43661206
125NEK20.43379959
126BTK0.41525435
127STK100.41229826
128FGFR10.39950446
129AURKA0.39763849
130PRKAA20.39654139
131AURKB0.39570644
132BCKDK0.38002758
133PIM20.37440901
134LYN0.36981801
135CDC70.36753560
136* CAMK2A0.35915952
137CSNK2A10.35530788
138ABL10.35394244
139CSNK1A10.34230629
140CAMKK20.33576317
141DAPK20.33319723
142STK30.33061194
143PIK3CG0.33053469
144MARK10.32411932
145CSNK1E0.32378799
146AKT30.30666547
147BRSK10.27689230
148CSNK2A20.27570410
149CAMK2D0.27049373
150ADRBK10.26188119
151PRKACB0.25513197

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.66744030
2RNA polymerase_Homo sapiens_hsa030203.59990296
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.22751853
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.22261405
5Basal transcription factors_Homo sapiens_hsa030223.19468129
6Propanoate metabolism_Homo sapiens_hsa006402.60619496
7RNA degradation_Homo sapiens_hsa030182.57817190
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.48397794
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16375228
10Cell cycle_Homo sapiens_hsa041101.97202709
11Circadian rhythm_Homo sapiens_hsa047101.95465878
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91556651
13Homologous recombination_Homo sapiens_hsa034401.90237814
14Folate biosynthesis_Homo sapiens_hsa007901.86471840
15Butanoate metabolism_Homo sapiens_hsa006501.86223924
16Other glycan degradation_Homo sapiens_hsa005111.82152424
17Fanconi anemia pathway_Homo sapiens_hsa034601.78247405
18Pyrimidine metabolism_Homo sapiens_hsa002401.73169993
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71062725
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69922049
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.68878961
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62403255
23Linoleic acid metabolism_Homo sapiens_hsa005911.60624264
24Non-homologous end-joining_Homo sapiens_hsa034501.58247894
25Fatty acid elongation_Homo sapiens_hsa000621.57009357
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.56220684
27Base excision repair_Homo sapiens_hsa034101.54584717
28Selenocompound metabolism_Homo sapiens_hsa004501.53703099
29Ether lipid metabolism_Homo sapiens_hsa005651.52935741
30Sphingolipid metabolism_Homo sapiens_hsa006001.48421496
31Allograft rejection_Homo sapiens_hsa053301.46120782
32Nucleotide excision repair_Homo sapiens_hsa034201.43030202
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39317432
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38927164
35Regulation of autophagy_Homo sapiens_hsa041401.38744057
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38526654
37Purine metabolism_Homo sapiens_hsa002301.37601769
38Autoimmune thyroid disease_Homo sapiens_hsa053201.36955768
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35601888
40Primary immunodeficiency_Homo sapiens_hsa053401.30424467
41Asthma_Homo sapiens_hsa053101.26103804
42Ovarian steroidogenesis_Homo sapiens_hsa049131.25972913
43RNA transport_Homo sapiens_hsa030131.23468156
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22554076
45Nicotine addiction_Homo sapiens_hsa050331.22184479
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21642628
47Vitamin B6 metabolism_Homo sapiens_hsa007501.21551066
48One carbon pool by folate_Homo sapiens_hsa006701.21345629
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.20646593
50Hematopoietic cell lineage_Homo sapiens_hsa046401.18824317
51Proteasome_Homo sapiens_hsa030501.17746714
52Herpes simplex infection_Homo sapiens_hsa051681.16375674
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15541951
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14967058
55Phototransduction_Homo sapiens_hsa047441.14357362
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13864022
57Pyruvate metabolism_Homo sapiens_hsa006201.13384958
58Graft-versus-host disease_Homo sapiens_hsa053321.13250293
59NF-kappa B signaling pathway_Homo sapiens_hsa040641.13025986
60Peroxisome_Homo sapiens_hsa041461.11872706
61Mismatch repair_Homo sapiens_hsa034301.09767222
62Arachidonic acid metabolism_Homo sapiens_hsa005901.08783607
63Sulfur metabolism_Homo sapiens_hsa009201.08458189
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08264161
65* p53 signaling pathway_Homo sapiens_hsa041151.08137068
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06055913
67Collecting duct acid secretion_Homo sapiens_hsa049661.05041390
68DNA replication_Homo sapiens_hsa030301.04129705
69Nitrogen metabolism_Homo sapiens_hsa009101.03731784
70Spliceosome_Homo sapiens_hsa030400.98567029
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97065179
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.96787162
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92921063
74Ribosome_Homo sapiens_hsa030100.90703851
75Glutathione metabolism_Homo sapiens_hsa004800.88552168
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84561642
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84081100
78Huntingtons disease_Homo sapiens_hsa050160.82246065
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81985786
80Pancreatic secretion_Homo sapiens_hsa049720.80073149
81* Measles_Homo sapiens_hsa051620.79199938
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74388256
83Rheumatoid arthritis_Homo sapiens_hsa053230.73234821
84Fatty acid metabolism_Homo sapiens_hsa012120.73064260
85Oxidative phosphorylation_Homo sapiens_hsa001900.70539367
86Legionellosis_Homo sapiens_hsa051340.69445224
87Hepatitis B_Homo sapiens_hsa051610.68800017
88Taste transduction_Homo sapiens_hsa047420.66054287
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65232867
90Tryptophan metabolism_Homo sapiens_hsa003800.65212698
91Prolactin signaling pathway_Homo sapiens_hsa049170.64147411
92TGF-beta signaling pathway_Homo sapiens_hsa043500.63843577
93Epstein-Barr virus infection_Homo sapiens_hsa051690.63269260
94beta-Alanine metabolism_Homo sapiens_hsa004100.61212845
95* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60957040
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60627797
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59895807
98Influenza A_Homo sapiens_hsa051640.59505964
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59079049
100Fatty acid degradation_Homo sapiens_hsa000710.58859380
101Arginine and proline metabolism_Homo sapiens_hsa003300.58457947
102Pancreatic cancer_Homo sapiens_hsa052120.57875327
103mRNA surveillance pathway_Homo sapiens_hsa030150.57100453
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56942655
105Olfactory transduction_Homo sapiens_hsa047400.56243866
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55713914
107Carbon metabolism_Homo sapiens_hsa012000.55208655
108Type I diabetes mellitus_Homo sapiens_hsa049400.54826831
109GABAergic synapse_Homo sapiens_hsa047270.52192017
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51050301
111Retinol metabolism_Homo sapiens_hsa008300.49614760
112Antigen processing and presentation_Homo sapiens_hsa046120.49572911
113Leishmaniasis_Homo sapiens_hsa051400.49052941
114Fat digestion and absorption_Homo sapiens_hsa049750.47237167
115Shigellosis_Homo sapiens_hsa051310.47219537
116Oocyte meiosis_Homo sapiens_hsa041140.47168675
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46689100
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.45930855
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45642668
120Caffeine metabolism_Homo sapiens_hsa002320.45408472
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45026485
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.44464474
123Cardiac muscle contraction_Homo sapiens_hsa042600.44318466
124Dopaminergic synapse_Homo sapiens_hsa047280.43728484
125FoxO signaling pathway_Homo sapiens_hsa040680.43334885
126Parkinsons disease_Homo sapiens_hsa050120.42463239
127Prostate cancer_Homo sapiens_hsa052150.42263898
128Circadian entrainment_Homo sapiens_hsa047130.42005445
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41699329
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41596248
131TNF signaling pathway_Homo sapiens_hsa046680.41556676
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41150474
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40602720
134Chemical carcinogenesis_Homo sapiens_hsa052040.39903372
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38730430
136Serotonergic synapse_Homo sapiens_hsa047260.37545012
137T cell receptor signaling pathway_Homo sapiens_hsa046600.37229893
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37077793
139Malaria_Homo sapiens_hsa051440.35706203
140Histidine metabolism_Homo sapiens_hsa003400.35509455
141Thyroid cancer_Homo sapiens_hsa052160.35209991
142Morphine addiction_Homo sapiens_hsa050320.32929190
143Metabolic pathways_Homo sapiens_hsa011000.31863238
144Choline metabolism in cancer_Homo sapiens_hsa052310.26852555
145Vibrio cholerae infection_Homo sapiens_hsa051100.23126941
146Colorectal cancer_Homo sapiens_hsa052100.22913924
147N-Glycan biosynthesis_Homo sapiens_hsa005100.21664788
148Alzheimers disease_Homo sapiens_hsa050100.21345932
149Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20096432
150Steroid biosynthesis_Homo sapiens_hsa001000.19576645
151Vitamin digestion and absorption_Homo sapiens_hsa049770.19233228

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