RCN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)5.63532965
2establishment of apical/basal cell polarity (GO:0035089)5.28485983
3embryonic process involved in female pregnancy (GO:0060136)4.63193661
4protein heterotrimerization (GO:0070208)4.54179348
5establishment of monopolar cell polarity (GO:0061162)4.47144611
6establishment or maintenance of monopolar cell polarity (GO:0061339)4.47144611
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.43388135
8protein retention in ER lumen (GO:0006621)4.21466661
9cell adhesion mediated by integrin (GO:0033627)4.19254633
10collagen fibril organization (GO:0030199)4.10669648
11polarized epithelial cell differentiation (GO:0030859)4.04987340
12regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.90916928
13negative regulation of chondrocyte differentiation (GO:0032331)3.84751203
14neuron projection extension involved in neuron projection guidance (GO:1902284)3.72186458
15axon extension involved in axon guidance (GO:0048846)3.72186458
16peptidyl-proline hydroxylation (GO:0019511)3.68625255
17proline metabolic process (GO:0006560)3.68621109
18planar cell polarity pathway involved in neural tube closure (GO:0090179)3.64702384
19chondrocyte proliferation (GO:0035988)3.59135333
20paraxial mesoderm development (GO:0048339)3.56679396
21regulation of translational fidelity (GO:0006450)3.55018549
22COPI coating of Golgi vesicle (GO:0048205)3.54089884
23Golgi transport vesicle coating (GO:0048200)3.54089884
24convergent extension (GO:0060026)3.51496017
25anterior/posterior axis specification, embryo (GO:0008595)3.47929731
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.41590707
27regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.39462642
28negative regulation of cartilage development (GO:0061037)3.35926073
29G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.35165270
30ectodermal placode formation (GO:0060788)3.35140429
31regulation of integrin activation (GO:0033623)3.30225106
32cell migration involved in sprouting angiogenesis (GO:0002042)3.29694422
33hippo signaling (GO:0035329)3.28766037
34embryonic camera-type eye development (GO:0031076)3.28148653
35protein hydroxylation (GO:0018126)3.27991252
36transcription from mitochondrial promoter (GO:0006390)3.24815497
37anatomical structure regression (GO:0060033)3.24365062
38retina vasculature morphogenesis in camera-type eye (GO:0061299)3.23442479
39prostate gland epithelium morphogenesis (GO:0060740)3.17661085
40branching involved in prostate gland morphogenesis (GO:0060442)3.17446294
41formation of translation preinitiation complex (GO:0001731)3.17116857
42bone trabecula formation (GO:0060346)3.16570281
43glial cell migration (GO:0008347)3.16262940
44regulation of hippo signaling (GO:0035330)3.10036657
45regulation of establishment of planar polarity (GO:0090175)3.07738244
46endodermal cell differentiation (GO:0035987)3.05164427
47wound healing, spreading of epidermal cells (GO:0035313)3.02359403
48endothelial cell morphogenesis (GO:0001886)3.00227897
49kidney mesenchyme development (GO:0072074)2.97088506
50mitotic G1 DNA damage checkpoint (GO:0031571)2.93792282
51extracellular fibril organization (GO:0043206)2.93361188
52face development (GO:0060324)2.91859355
53cellular response to ATP (GO:0071318)2.91271072
54establishment of planar polarity (GO:0001736)2.89430848
55establishment of tissue polarity (GO:0007164)2.89430848
56mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.87584752
57embryonic placenta development (GO:0001892)2.86143812
58cell surface receptor signaling pathway involved in heart development (GO:0061311)2.86012267
59collagen metabolic process (GO:0032963)2.83723890
60metanephric mesenchyme development (GO:0072075)2.81260594
61regulation of heart morphogenesis (GO:2000826)2.80790014
62cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.79970332
63embryonic skeletal joint morphogenesis (GO:0060272)2.79799400
64negative regulation of embryonic development (GO:0045992)2.79479665
65replication fork processing (GO:0031297)2.79172090
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.78096874
67epithelial cell-cell adhesion (GO:0090136)2.77350082
68regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.76981918
69apoptotic cell clearance (GO:0043277)2.76609065
70collagen catabolic process (GO:0030574)2.75955354
71sequestering of extracellular ligand from receptor (GO:0035581)2.74710640
72embryonic eye morphogenesis (GO:0048048)2.74585587
73dorsal/ventral axis specification (GO:0009950)2.71674425
74muscle cell migration (GO:0014812)2.71290104
75regulation of SMAD protein import into nucleus (GO:0060390)2.71121922
76midgut development (GO:0007494)2.69772742
77positive regulation of SMAD protein import into nucleus (GO:0060391)2.69617698
78negative regulation of catenin import into nucleus (GO:0035414)2.68445193
79oxidative demethylation (GO:0070989)2.67460977
80multicellular organismal macromolecule metabolic process (GO:0044259)2.67224979
81negative regulation of cell cycle arrest (GO:0071157)2.65725529
82proximal/distal pattern formation (GO:0009954)2.65694669
83basement membrane organization (GO:0071711)2.65099673
84wound healing, spreading of cells (GO:0044319)2.64217950
85dosage compensation (GO:0007549)2.63841042
86notochord development (GO:0030903)2.63428429
87activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.62891572
88prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.62263859
89protein maturation by protein folding (GO:0022417)2.61500835
904-hydroxyproline metabolic process (GO:0019471)2.61044530
91regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.60870091
92eye morphogenesis (GO:0048592)2.60655635
93apoptotic process involved in morphogenesis (GO:0060561)2.59484316
94N-glycan processing (GO:0006491)2.59023580
95dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.57407241
96establishment of integrated proviral latency (GO:0075713)2.56127824
97positive regulation of nuclease activity (GO:0032075)2.56056848
98Notch signaling involved in heart development (GO:0061314)2.55964239
99somatic hypermutation of immunoglobulin genes (GO:0016446)2.55498816
100somatic diversification of immune receptors via somatic mutation (GO:0002566)2.55498816
101bone morphogenesis (GO:0060349)2.55373116
102multicellular organismal catabolic process (GO:0044243)2.55148262
103chondrocyte development (GO:0002063)2.51907513
104G1 DNA damage checkpoint (GO:0044783)2.51434997
105skin morphogenesis (GO:0043589)2.50584754
106regulation of sister chromatid cohesion (GO:0007063)2.50495469
107substrate-dependent cell migration (GO:0006929)2.50392632
108regulation of chondrocyte differentiation (GO:0032330)2.49931524
109Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.49709066
110spliceosomal tri-snRNP complex assembly (GO:0000244)2.49585524
111positive regulation of protein homooligomerization (GO:0032464)2.49437045
112epithelial to mesenchymal transition (GO:0001837)2.48253439
113establishment or maintenance of bipolar cell polarity (GO:0061245)2.47943160
114establishment or maintenance of apical/basal cell polarity (GO:0035088)2.47943160
115multicellular organismal metabolic process (GO:0044236)2.47733828
116retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.47521100
117vascular endothelial growth factor signaling pathway (GO:0038084)2.46567783
118non-canonical Wnt signaling pathway (GO:0035567)2.46400793
119organ induction (GO:0001759)2.45796613
120cellular response to vitamin (GO:0071295)2.45756654
121COPII vesicle coating (GO:0048208)2.45627070
122branching involved in salivary gland morphogenesis (GO:0060445)2.45451813
123negative regulation of axon extension involved in axon guidance (GO:0048843)2.45328327
124extracellular matrix disassembly (GO:0022617)2.44989953
125mitotic cell cycle arrest (GO:0071850)2.44725861
126body morphogenesis (GO:0010171)2.44577933
127cochlea morphogenesis (GO:0090103)2.44233077
128regulation of gene silencing by RNA (GO:0060966)2.43483422
129regulation of posttranscriptional gene silencing (GO:0060147)2.43483422
130regulation of gene silencing by miRNA (GO:0060964)2.43483422
131protein localization to cell surface (GO:0034394)2.43468252
132axon extension (GO:0048675)2.43287168
133positive regulation of cartilage development (GO:0061036)2.43261805
134cellular response to vitamin D (GO:0071305)2.43073814
135outer ear morphogenesis (GO:0042473)2.42547479
136lateral sprouting from an epithelium (GO:0060601)2.42383048
137nodal signaling pathway (GO:0038092)2.42028410
138lens fiber cell development (GO:0070307)2.41343541
139type B pancreatic cell proliferation (GO:0044342)2.40869541
140mesenchymal-epithelial cell signaling (GO:0060638)2.40729178
141L-serine metabolic process (GO:0006563)2.40387414
142negative regulation of axon guidance (GO:1902668)2.39566766
143heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.38796136
144negative regulation of stem cell proliferation (GO:2000647)2.37619828
145morphogenesis of an epithelial sheet (GO:0002011)2.35693921
146ganglion development (GO:0061548)2.34642911
147regulation of cartilage development (GO:0061035)2.34051152
148glomerular visceral epithelial cell development (GO:0072015)2.32353586
149barbed-end actin filament capping (GO:0051016)2.29955225
150negative regulation of smooth muscle cell migration (GO:0014912)2.29847306
151cell migration involved in heart development (GO:0060973)2.28291867
152fibril organization (GO:0097435)2.25948489
153craniofacial suture morphogenesis (GO:0097094)2.25813017
154hemidesmosome assembly (GO:0031581)2.25331804
155establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.25082483
156regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.24025976
157extracellular matrix organization (GO:0030198)2.23987058
158blood vessel endothelial cell migration (GO:0043534)2.23173284
159extracellular structure organization (GO:0043062)2.22897752
160DNA unwinding involved in DNA replication (GO:0006268)2.22677549
161regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.21220692
162regulation of cell fate specification (GO:0042659)2.20209781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.86480429
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.05578868
3WT1_19549856_ChIP-ChIP_CCG9911_Human3.15910323
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.10796139
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.01613325
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.01613325
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.01613325
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.71963036
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56936070
10E2F7_22180533_ChIP-Seq_HELA_Human2.44776743
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35910321
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.23175963
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.20996501
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.18172074
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.12565596
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.10225764
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.09146409
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.06956313
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.06227174
20* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.05688684
21ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.03630901
22* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.01078480
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.00796812
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.96873173
25CLOCK_20551151_ChIP-Seq_293T_Human1.94693542
26ZNF263_19887448_ChIP-Seq_K562_Human1.91493837
27* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.85731823
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.83307553
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81960336
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81584421
31* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.80147395
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77155239
33* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.76625936
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.75965178
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.75142650
36* ELK3_25401928_ChIP-Seq_HUVEC_Human1.70289913
37CJUN_26792858_Chip-Seq_BT549_Human1.67438435
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.67062021
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65203472
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.61258645
41RACK7_27058665_Chip-Seq_MCF-7_Human1.60142799
42* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.59212691
43MYC_22102868_ChIP-Seq_BL_Human1.58880763
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.58366637
45* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57038429
46* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.53617665
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53067488
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51739515
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.47969284
50VDR_21846776_ChIP-Seq_THP-1_Human1.47739724
51* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47533162
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47372475
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46205612
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.46097683
55TP53_18474530_ChIP-ChIP_U2OS_Human1.45537849
56SOX17_20123909_ChIP-Seq_XEN_Mouse1.45007288
57* ATF3_27146783_Chip-Seq_COLON_Human1.44858610
58LXR_22292898_ChIP-Seq_THP-1_Human1.44414680
59TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44257567
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.43338889
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41395491
62* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.40246315
63POU5F1_16518401_ChIP-PET_MESCs_Mouse1.39996348
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39947887
65* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38777360
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36987190
67* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36839498
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.35736729
69EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.35587177
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35427504
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34280535
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34253407
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33206988
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32329532
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.31843819
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31635865
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31635865
78* NANOG_21062744_ChIP-ChIP_HESCs_Human1.29750621
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29399618
80* CHD1_26751641_Chip-Seq_LNCaP_Human1.29292651
81* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.28758612
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.28669145
83* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28429839
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28255778
85* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27812211
86AR_21909140_ChIP-Seq_LNCAP_Human1.26848546
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25817551
88* TP53_22127205_ChIP-Seq_IMR90_Human1.24349741
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24192187
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22961128
91MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22287746
92* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.20814790
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20296395
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19628750
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19427270
96UBF1/2_26484160_Chip-Seq_HMECs_Human1.13751303
97TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13143895
98TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12978082
99NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12910699
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12910699
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12479013
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12417634
103BRD4_25478319_ChIP-Seq_HGPS_Human1.12250558
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11915647
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11661910
106* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10424216
107* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10113992
108* KDM2B_26808549_Chip-Seq_DND41_Human1.09581086
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09528943
110SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08971740
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08966095
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08841965
113MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08216468
114ESR2_21235772_ChIP-Seq_MCF-7_Human1.07631740
115ISL1_27105846_Chip-Seq_CPCs_Mouse1.06356472
116* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06068833
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06016020
118ESR1_21235772_ChIP-Seq_MCF-7_Human1.05854924
119* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05789114
120NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05633446
121* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05098056
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04858129
123SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04751374
124HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04105892
125* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02888229
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02599309
127TP63_19390658_ChIP-ChIP_HaCaT_Human1.02215774
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01700724
129XRN2_22483619_ChIP-Seq_HELA_Human1.01131744
130* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00175487
131* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00097160
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99974592
133* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99864673
134NANOG_16153702_ChIP-ChIP_HESCs_Human0.99298379
135RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98925535
136EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98925535
137SA1_22415368_ChIP-Seq_MEFs_Mouse0.98398041
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97947980
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95666347
140SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90994026
141HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90693332
142ELK1_19687146_ChIP-ChIP_HELA_Human0.90051083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.29780320
2MP0003705_abnormal_hypodermis_morpholog3.62913984
3MP0005275_abnormal_skin_tensile3.56452631
4MP0010030_abnormal_orbit_morphology3.46992235
5MP0005503_abnormal_tendon_morphology2.99037376
6MP0010352_gastrointestinal_tract_polyps2.63675323
7MP0010368_abnormal_lymphatic_system2.43980721
8MP0004272_abnormal_basement_membrane2.20763983
9MP0005623_abnormal_meninges_morphology2.13496806
10MP0003279_aneurysm2.04895393
11MP0003283_abnormal_digestive_organ2.01241433
12MP0002282_abnormal_trachea_morphology1.95152585
13MP0009053_abnormal_anal_canal1.91906514
14MP0005508_abnormal_skeleton_morphology1.84933462
15MP0004858_abnormal_nervous_system1.84246211
16MP0000537_abnormal_urethra_morphology1.83826300
17MP0004233_abnormal_muscle_weight1.83503499
18MP0002060_abnormal_skin_morphology1.82784490
19MP0009278_abnormal_bone_marrow1.82438678
20MP0003941_abnormal_skin_development1.81629445
21MP0003385_abnormal_body_wall1.79816151
22MP0002009_preneoplasia1.77917735
23MP0003566_abnormal_cell_adhesion1.76722134
24MP0005076_abnormal_cell_differentiation1.76123261
25MP0006054_spinal_hemorrhage1.72937916
26MP0009384_cardiac_valve_regurgitation1.70804068
27MP0005171_absent_coat_pigmentation1.70609737
28MP0005023_abnormal_wound_healing1.67352190
29MP0003942_abnormal_urinary_system1.65698359
30MP0001958_emphysema1.64478168
31MP0009250_abnormal_appendicular_skeleto1.64191916
32MP0002932_abnormal_joint_morphology1.59797899
33MP0002249_abnormal_larynx_morphology1.55034789
34MP0000534_abnormal_ureter_morphology1.50120825
35MP0004197_abnormal_fetal_growth/weight/1.41685512
36MP0000762_abnormal_tongue_morphology1.40700289
37MP0003755_abnormal_palate_morphology1.40467714
38MP0002111_abnormal_tail_morphology1.38728213
39MP0001542_abnormal_bone_strength1.38633828
40MP0010234_abnormal_vibrissa_follicle1.36273148
41MP0002233_abnormal_nose_morphology1.35651455
42MP0000516_abnormal_urinary_system1.34954921
43MP0005367_renal/urinary_system_phenotyp1.34954921
44MP0001879_abnormal_lymphatic_vessel1.33683163
45MP0000751_myopathy1.32510700
46MP0005197_abnormal_uvea_morphology1.31961859
47MP0002084_abnormal_developmental_patter1.31702595
48MP0003935_abnormal_craniofacial_develop1.31172062
49MP0008057_abnormal_DNA_replication1.29211046
50MP0004134_abnormal_chest_morphology1.27319724
51MP0003119_abnormal_digestive_system1.25587857
52MP0000428_abnormal_craniofacial_morphol1.24376838
53MP0000733_abnormal_muscle_development1.23887586
54MP0002896_abnormal_bone_mineralization1.22120900
55MP0002108_abnormal_muscle_morphology1.21393240
56MP0000049_abnormal_middle_ear1.19697056
57MP0004957_abnormal_blastocyst_morpholog1.19210719
58MP0000163_abnormal_cartilage_morphology1.18655356
59MP0002085_abnormal_embryonic_tissue1.17722785
60MP0001293_anophthalmia1.16455809
61MP0002086_abnormal_extraembryonic_tissu1.13361563
62MP0000432_abnormal_head_morphology1.12448536
63MP0002116_abnormal_craniofacial_bone1.12292745
64MP0002115_abnormal_skeleton_extremities1.12241216
65MP0001299_abnormal_eye_distance/1.11311984
66MP0003567_abnormal_fetal_cardiomyocyte1.10058660
67MP0002114_abnormal_axial_skeleton1.08892183
68MP0003937_abnormal_limbs/digits/tail_de1.08335831
69MP0009780_abnormal_chondrocyte_physiolo1.07209321
70MP0003890_abnormal_embryonic-extraembry1.06591682
71MP0003123_paternal_imprinting1.06116526
72MP0003453_abnormal_keratinocyte_physiol1.04458001
73MP0002697_abnormal_eye_size1.04350126
74MP0002109_abnormal_limb_morphology1.02608714
75MP0001697_abnormal_embryo_size1.02546553
76MP0001243_abnormal_dermal_layer1.02205126
77MP0000778_abnormal_nervous_system1.01619989
78MP0002166_altered_tumor_susceptibility1.01148429
79MP0000013_abnormal_adipose_tissue1.00407668
80MP0003115_abnormal_respiratory_system0.99729987
81MP0003091_abnormal_cell_migration0.99367605
82MP0001915_intracranial_hemorrhage0.98950438
83MP0005257_abnormal_intraocular_pressure0.98595095
84MP0001286_abnormal_eye_development0.97496982
85MP0000350_abnormal_cell_proliferation0.95547215
86MP0005380_embryogenesis_phenotype0.92998994
87MP0001672_abnormal_embryogenesis/_devel0.92998994
88MP0002113_abnormal_skeleton_development0.91823572
89MP0002089_abnormal_postnatal_growth/wei0.90739726
90MP0002653_abnormal_ependyma_morphology0.90513967
91MP0003315_abnormal_perineum_morphology0.88932832
92MP0000467_abnormal_esophagus_morphology0.88839299
93MP0005248_abnormal_Harderian_gland0.88789562
94MP0009697_abnormal_copulation0.88100300
95MP0002796_impaired_skin_barrier0.87915521
96MP0002177_abnormal_outer_ear0.87791992
97MP0002295_abnormal_pulmonary_circulatio0.87326337
98MP0005595_abnormal_vascular_smooth0.87088763
99MP0000767_abnormal_smooth_muscle0.86772347
100MP0008932_abnormal_embryonic_tissue0.86372214
101MP0004133_heterotaxia0.85103438
102MP0002092_abnormal_eye_morphology0.84229414
103MP0003950_abnormal_plasma_membrane0.83305052
104MP0002925_abnormal_cardiovascular_devel0.82974515
105MP0002877_abnormal_melanocyte_morpholog0.82824538
106MP0002088_abnormal_embryonic_growth/wei0.82603682
107MP0003984_embryonic_growth_retardation0.82491867
108MP0001340_abnormal_eyelid_morphology0.82385473
109MP0005193_abnormal_anterior_eye0.81656312
110MP0002938_white_spotting0.81150008
111MP0000579_abnormal_nail_morphology0.80341853
112MP0003136_yellow_coat_color0.79098162
113MP0000462_abnormal_digestive_system0.78837579
114MP0003045_fibrosis0.78039811
115MP0000613_abnormal_salivary_gland0.76803238
116MP0005501_abnormal_skin_physiology0.76705983
117MP0005390_skeleton_phenotype0.76649320
118MP0005187_abnormal_penis_morphology0.76528272
119MP0001614_abnormal_blood_vessel0.76445802
120MP0003122_maternal_imprinting0.74207671
121MP0001730_embryonic_growth_arrest0.73923190
122MP0002080_prenatal_lethality0.73624828
123MP0001849_ear_inflammation0.73487155
124MP0003861_abnormal_nervous_system0.72643668
125MP0008789_abnormal_olfactory_epithelium0.72270071
126MP0002234_abnormal_pharynx_morphology0.70740762
127MP0005391_vision/eye_phenotype0.67132628

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.06198245
2Premature rupture of membranes (HP:0001788)5.29442726
3Cerebral aneurysm (HP:0004944)3.84040038
4Aortic dissection (HP:0002647)3.75641391
5Ankle contracture (HP:0006466)3.60019485
6Arterial tortuosity (HP:0005116)3.48179777
7Shallow orbits (HP:0000586)3.46003690
8Aortic aneurysm (HP:0004942)3.45143565
9Ulnar bowing (HP:0003031)3.37235877
10Atrophic scars (HP:0001075)3.25278222
11Soft skin (HP:0000977)3.24253829
12Coronal craniosynostosis (HP:0004440)2.91521426
13Abnormality of dentin (HP:0010299)2.90255879
14Cervical subluxation (HP:0003308)2.90068529
15Bladder diverticulum (HP:0000015)2.86084113
16Fragile skin (HP:0001030)2.75041744
17Genu recurvatum (HP:0002816)2.73690172
18Dilatation of the ascending aorta (HP:0005111)2.73597327
19Blue sclerae (HP:0000592)2.72460263
20Neonatal short-limb short stature (HP:0008921)2.61851625
21Hypoplastic ischia (HP:0003175)2.58505090
22Alopecia of scalp (HP:0002293)2.54625260
23Wormian bones (HP:0002645)2.53986881
24Turricephaly (HP:0000262)2.53837937
25Selective tooth agenesis (HP:0001592)2.50506994
26Peritonitis (HP:0002586)2.44053712
27Short humerus (HP:0005792)2.43445846
28Mitral valve prolapse (HP:0001634)2.43313898
29Breech presentation (HP:0001623)2.39491749
30Short nail (HP:0001799)2.38531681
31Bowed forearm bones (HP:0003956)2.36412364
32Bowing of the arm (HP:0006488)2.36412364
33Elbow flexion contracture (HP:0002987)2.35705262
34Vertebral hypoplasia (HP:0008417)2.33205668
35Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.33205668
36Rib fusion (HP:0000902)2.31773706
37Type 1 muscle fiber predominance (HP:0003803)2.30592699
38Hyperacusis (HP:0010780)2.29675223
39Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.29629713
40Hyperextensible skin (HP:0000974)2.29462159
41Aplasia/hypoplasia of the humerus (HP:0006507)2.27470453
42Spinal rigidity (HP:0003306)2.25344392
43Congenital hip dislocation (HP:0001374)2.23421664
44Bowel diverticulosis (HP:0005222)2.21321872
45Broad metatarsal (HP:0001783)2.21166091
46Abnormality of the ischium (HP:0003174)2.20518232
47Aneurysm (HP:0002617)2.19932439
48Facial hemangioma (HP:0000329)2.19135610
49Abnormal delivery (HP:0001787)2.17604141
50Joint laxity (HP:0001388)2.14269096
51Abnormality of the calcaneus (HP:0008364)2.13238387
52Follicular hyperkeratosis (HP:0007502)2.11619566
53Vertebral compression fractures (HP:0002953)2.06896857
54Shawl scrotum (HP:0000049)2.04364693
55Joint stiffness (HP:0001387)2.04274799
56Mitral regurgitation (HP:0001653)2.03994254
57Short 5th finger (HP:0009237)2.03565949
58Biconcave vertebral bodies (HP:0004586)2.02644244
59Abnormal hemoglobin (HP:0011902)2.00304602
60Insomnia (HP:0100785)1.99345242
61Mildly elevated creatine phosphokinase (HP:0008180)1.99263978
62Broad long bones (HP:0005622)1.99083597
63Osteolytic defects of the hand bones (HP:0009699)1.98855950
64Osteolytic defects of the phalanges of the hand (HP:0009771)1.98855950
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97834941
66Short 4th metacarpal (HP:0010044)1.97834941
67Congenital glaucoma (HP:0001087)1.97770595
68Increased connective tissue (HP:0009025)1.97548780
69Deviation of the hallux (HP:0010051)1.97422674
70Overgrowth (HP:0001548)1.95911381
71Overriding aorta (HP:0002623)1.95905547
72Ectopia lentis (HP:0001083)1.95085190
73Broad thumb (HP:0011304)1.94787189
74Inguinal hernia (HP:0000023)1.93785258
75Mild short stature (HP:0003502)1.93560983
76Concave nail (HP:0001598)1.92245905
77Natal tooth (HP:0000695)1.91666310
78Camptodactyly of toe (HP:0001836)1.90438147
79Abnormality of the acetabulum (HP:0003170)1.87597047
80Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.86873738
81Radial bowing (HP:0002986)1.86643143
82Hallux valgus (HP:0001822)1.86331470
83Pterygium (HP:0001059)1.86172929
84Back pain (HP:0003418)1.86112017
85Limb-girdle muscle weakness (HP:0003325)1.85501774
86Arnold-Chiari malformation (HP:0002308)1.85146325
87Absent frontal sinuses (HP:0002688)1.84973624
88Renovascular hypertension (HP:0100817)1.83693452
89Round ear (HP:0100830)1.83599405
90Wrist flexion contracture (HP:0001239)1.83323428
91Platyspondyly (HP:0000926)1.81387470
92Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.81304262
93Vertebral arch anomaly (HP:0008438)1.81285578
94Calcaneovalgus deformity (HP:0001848)1.81135553
95Knee flexion contracture (HP:0006380)1.81001593
96Aortic regurgitation (HP:0001659)1.79900934
97Hypoplasia of the iris (HP:0007676)1.79635715
98Generalized amyotrophy (HP:0003700)1.79631655
99Mesomelia (HP:0003027)1.79357953
100Protruding ear (HP:0000411)1.77668590
101Rhizomelia (HP:0008905)1.76980647
102Broad phalanx (HP:0006009)1.75888750
103Broad toe (HP:0001837)1.75352613
104Annular pancreas (HP:0001734)1.75263739
105Carpal synostosis (HP:0009702)1.75002662
106Morphological abnormality of the middle ear (HP:0008609)1.74726637
107Missing ribs (HP:0000921)1.74117796
108Flat cornea (HP:0007720)1.73276720
109Abnormality of the 4th metacarpal (HP:0010012)1.72206972
110Broad phalanges of the hand (HP:0009768)1.71042237
111Increased density of long bones (HP:0006392)1.70274294
112Abnormality of the 2nd finger (HP:0004100)1.70200757
113Limb-girdle muscle atrophy (HP:0003797)1.70038485
114Renal duplication (HP:0000075)1.69783870
115Spinal cord lesions (HP:0100561)1.69253820
116Syringomyelia (HP:0003396)1.69253820
117Elfin facies (HP:0004428)1.68478722
118Metaphyseal cupping (HP:0003021)1.68273080
119Decreased skull ossification (HP:0004331)1.66914773
120Wide anterior fontanel (HP:0000260)1.65780537
121Rectal prolapse (HP:0002035)1.65417568
122Epiphyseal dysplasia (HP:0002656)1.64828243
123Bell-shaped thorax (HP:0001591)1.64806169
124Abnormality of skull ossification (HP:0002703)1.64219609
125Vitreoretinal degeneration (HP:0000655)1.63430958
126Increased variability in muscle fiber diameter (HP:0003557)1.62606135
127Deformed tarsal bones (HP:0008119)1.62573124
128Premature skin wrinkling (HP:0100678)1.62077693
129Broad ribs (HP:0000885)1.61535519
130Aplasia of the phalanges of the hand (HP:0009802)1.61325823
131Aplasia involving bones of the extremities (HP:0009825)1.61325823
132Aplasia involving bones of the upper limbs (HP:0009823)1.61325823
133Thin ribs (HP:0000883)1.60953990
134Spondylolisthesis (HP:0003302)1.60601582
135Vascular tortuosity (HP:0004948)1.60260435
136High anterior hairline (HP:0009890)1.60161719
137Osteopenia (HP:0000938)1.58892543
138Delayed cranial suture closure (HP:0000270)1.58274529
139Fibular hypoplasia (HP:0003038)1.56321761
140Thoracolumbar scoliosis (HP:0002944)1.56119325
141Hypoventilation (HP:0002791)1.55445789
142Vertebral clefting (HP:0008428)1.55224281
143Midface retrusion (HP:0011800)1.54618561
144Mitral stenosis (HP:0001718)1.54387338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.56318422
2PDGFRA3.39264285
3ICK3.30317963
4LATS12.93674870
5NTRK12.93591455
6TRIB32.83326738
7AKT32.72120009
8LATS22.62528400
9MAPK152.29284682
10MOS2.22422314
11TTN2.08711525
12BMX2.00089243
13NEK91.98152166
14PKN21.94719377
15EEF2K1.89018438
16TRPM71.84677214
17ERBB41.82625000
18TYRO31.78489650
19MAP3K61.77519778
20BCR1.74011999
21MST1R1.72843994
22TIE11.71968625
23PBK1.67947551
24MAP3K111.62189044
25DYRK1B1.61664274
26SIK11.58467382
27ERN11.58215546
28SRPK11.57515348
29PAK21.54423241
30RPS6KB21.46308919
31MATK1.39634392
32CDK61.38469697
33SCYL21.38324679
34PIM21.37403698
35MAPKAPK31.36657229
36MAP3K101.35811401
37CDK71.35325011
38MKNK11.32205720
39FLT31.31652328
40PLK21.26140098
41FER1.25758736
42RIPK11.23224136
43EPHA21.23152201
44STK31.17624556
45PRKD21.17487402
46ROCK21.15989165
47FGR1.15166839
48TTK1.13497481
49MTOR1.12725881
50LRRK21.11365753
51FRK1.07667369
52PTK21.06434711
53EPHB21.01809148
54FGFR11.00294661
55PLK30.99813887
56PNCK0.98737648
57PAK40.98036396
58TESK10.96234701
59CDK80.95249981
60CSNK1A1L0.94467991
61TNIK0.94160803
62UHMK10.93920692
63TGFBR20.91398352
64PTK60.91022777
65YES10.90220635
66CDC42BPA0.90043249
67PAK60.89035993
68DMPK0.87168831
69PDGFRB0.85734084
70ARAF0.84801282
71ERBB30.84650652
72TGFBR10.84598737
73CSK0.84498327
74MET0.83066093
75RPS6KC10.80719449
76RPS6KL10.80719449
77CSNK1G30.80175048
78CDK120.78619057
79CDK140.77839705
80CSNK1G10.76956553
81MKNK20.74642369
82EIF2AK30.74298461
83ILK0.74225151
84STK38L0.74221310
85LMTK20.72027753
86NEK10.71841122
87CSNK1G20.71612042
88MAP3K30.71354752
89CDK180.70853267
90MAP2K70.70167151
91EPHB10.70047652
92CDK150.69486898
93TSSK60.69434706
94RPS6KA40.69401223
95CDK11A0.68140784
96EIF2AK10.67714601
97ABL20.66854570
98VRK20.66353288
99GSK3A0.65067574
100NEK20.64805380
101RPS6KA60.64576719
102STK380.64372031
103TAF10.61779256
104DYRK30.61450420
105MYLK0.61306329
106BUB10.60420629
107LIMK10.58983401
108DAPK10.58687605
109STK100.58016365
110PIM10.57563721
111TESK20.57377654
112MAP3K80.55575486
113CDK90.53005729
114BRD40.52815446
115PRKD30.52711821
116BRSK10.51776301
117PAK30.51135252
118AKT20.49163409
119PLK10.48542364
120PINK10.48243332
121AURKA0.47518693
122AURKB0.45484947
123SMG10.44900591
124RPS6KA10.43601743
125CHEK20.42911749
126PIK3CG0.41870694
127KDR0.41745922
128EPHA30.41668601
129PAK10.41173402
130INSR0.40602235
131PDK20.40211561
132PRKCI0.38069887
133CHEK10.37929325
134BCKDK0.36570087
135CDC70.36450137
136ATR0.34714910
137BRSK20.33504977
138MAPK110.33360261
139TAOK10.33220428
140PHKG20.32749512
141PHKG10.32749512
142NME20.32163974
143HIPK20.31416688
144PIK3CA0.30990071
145ROCK10.30812981
146MAPK10.30263360
147WEE10.29659996
148EGFR0.29422943
149TAOK20.28782264
150PRKD10.26920958

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.75381758
2Hippo signaling pathway_Homo sapiens_hsa043902.68443110
3Adherens junction_Homo sapiens_hsa045202.39530574
4Focal adhesion_Homo sapiens_hsa045102.30476081
5Bladder cancer_Homo sapiens_hsa052192.29157497
6TGF-beta signaling pathway_Homo sapiens_hsa043502.26429224
7Mismatch repair_Homo sapiens_hsa034302.25821971
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.24397399
9Basal cell carcinoma_Homo sapiens_hsa052172.20128621
10Hedgehog signaling pathway_Homo sapiens_hsa043402.07143941
11Base excision repair_Homo sapiens_hsa034102.05743432
12Small cell lung cancer_Homo sapiens_hsa052221.89583038
13Proteoglycans in cancer_Homo sapiens_hsa052051.88189177
14Fatty acid biosynthesis_Homo sapiens_hsa000611.83830005
15DNA replication_Homo sapiens_hsa030301.83453852
16p53 signaling pathway_Homo sapiens_hsa041151.79682900
17mTOR signaling pathway_Homo sapiens_hsa041501.78925640
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.78302156
19MicroRNAs in cancer_Homo sapiens_hsa052061.77101886
20Wnt signaling pathway_Homo sapiens_hsa043101.63904319
21Protein export_Homo sapiens_hsa030601.62581350
22Protein digestion and absorption_Homo sapiens_hsa049741.62487645
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.61514093
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.61198826
25Notch signaling pathway_Homo sapiens_hsa043301.59191608
26Chronic myeloid leukemia_Homo sapiens_hsa052201.54821465
27RNA transport_Homo sapiens_hsa030131.52004108
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51637419
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.48946320
30Tight junction_Homo sapiens_hsa045301.47180804
31N-Glycan biosynthesis_Homo sapiens_hsa005101.45498940
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45141178
33Cell cycle_Homo sapiens_hsa041101.44996903
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41583852
35Steroid biosynthesis_Homo sapiens_hsa001001.40782335
36Spliceosome_Homo sapiens_hsa030401.39003645
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33431663
38Nucleotide excision repair_Homo sapiens_hsa034201.32794923
39PI3K-Akt signaling pathway_Homo sapiens_hsa041511.31098641
40mRNA surveillance pathway_Homo sapiens_hsa030151.30606656
41Ribosome_Homo sapiens_hsa030101.29628600
42Colorectal cancer_Homo sapiens_hsa052101.28270023
43Folate biosynthesis_Homo sapiens_hsa007901.25873346
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23730432
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21455036
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20556055
47Prostate cancer_Homo sapiens_hsa052151.20119492
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15061603
49Thyroid cancer_Homo sapiens_hsa052161.14084027
50Amoebiasis_Homo sapiens_hsa051461.12560132
51Carbon metabolism_Homo sapiens_hsa012001.11690311
52Melanoma_Homo sapiens_hsa052181.10348953
53Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09085593
54Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08757687
55Pathways in cancer_Homo sapiens_hsa052001.08134813
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07287803
57Endometrial cancer_Homo sapiens_hsa052131.06479787
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.05839354
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05332120
60Shigellosis_Homo sapiens_hsa051311.05103406
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02800732
62Pentose phosphate pathway_Homo sapiens_hsa000301.01742593
63Galactose metabolism_Homo sapiens_hsa000520.99433661
64Vitamin B6 metabolism_Homo sapiens_hsa007500.98711997
65Viral myocarditis_Homo sapiens_hsa054160.97916185
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97576511
67HTLV-I infection_Homo sapiens_hsa051660.97367439
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96828509
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96075416
70Pyruvate metabolism_Homo sapiens_hsa006200.92910047
71Pancreatic cancer_Homo sapiens_hsa052120.91650566
72Viral carcinogenesis_Homo sapiens_hsa052030.89840608
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88777238
74VEGF signaling pathway_Homo sapiens_hsa043700.88188358
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87228842
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86126067
77Non-homologous end-joining_Homo sapiens_hsa034500.84121332
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.83487248
79Glutathione metabolism_Homo sapiens_hsa004800.82801325
80One carbon pool by folate_Homo sapiens_hsa006700.81048763
81Prion diseases_Homo sapiens_hsa050200.80959539
82Glioma_Homo sapiens_hsa052140.78512404
83Dilated cardiomyopathy_Homo sapiens_hsa054140.77371928
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75583067
85Gap junction_Homo sapiens_hsa045400.74836325
86Lysine degradation_Homo sapiens_hsa003100.72973478
87Vibrio cholerae infection_Homo sapiens_hsa051100.71577769
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71524052
89Oocyte meiosis_Homo sapiens_hsa041140.71284745
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.69581350
91HIF-1 signaling pathway_Homo sapiens_hsa040660.69163192
92Melanogenesis_Homo sapiens_hsa049160.68409381
93Rap1 signaling pathway_Homo sapiens_hsa040150.68384402
94Acute myeloid leukemia_Homo sapiens_hsa052210.67326277
95Selenocompound metabolism_Homo sapiens_hsa004500.66410006
96AMPK signaling pathway_Homo sapiens_hsa041520.66358800
97ErbB signaling pathway_Homo sapiens_hsa040120.66264085
98Arginine and proline metabolism_Homo sapiens_hsa003300.65830358
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65022231
100Pyrimidine metabolism_Homo sapiens_hsa002400.61170320
101Estrogen signaling pathway_Homo sapiens_hsa049150.60780436
102Thyroid hormone synthesis_Homo sapiens_hsa049180.59878520
103Renin-angiotensin system_Homo sapiens_hsa046140.59705835
104Hepatitis B_Homo sapiens_hsa051610.59446437
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58897757
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56286194
107Insulin signaling pathway_Homo sapiens_hsa049100.56073572
108Fructose and mannose metabolism_Homo sapiens_hsa000510.55415344
109Platelet activation_Homo sapiens_hsa046110.55410799
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53771959
111Propanoate metabolism_Homo sapiens_hsa006400.53592247
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52913406
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52310016
114Fatty acid elongation_Homo sapiens_hsa000620.51984432
115Non-small cell lung cancer_Homo sapiens_hsa052230.50981898
116Biosynthesis of amino acids_Homo sapiens_hsa012300.50517487
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.50340352
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49724533
119Sulfur metabolism_Homo sapiens_hsa009200.49311012
120Circadian rhythm_Homo sapiens_hsa047100.49020995
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46457822
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45928527
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45027628
124Fanconi anemia pathway_Homo sapiens_hsa034600.43174956
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43065115
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.41665412
127Legionellosis_Homo sapiens_hsa051340.41035696
128Sulfur relay system_Homo sapiens_hsa041220.40458443
129Prolactin signaling pathway_Homo sapiens_hsa049170.39797098
130Endocytosis_Homo sapiens_hsa041440.37583020
131FoxO signaling pathway_Homo sapiens_hsa040680.36936092
132Fatty acid metabolism_Homo sapiens_hsa012120.36514645
133Apoptosis_Homo sapiens_hsa042100.36378999
134Axon guidance_Homo sapiens_hsa043600.36288220
135Choline metabolism in cancer_Homo sapiens_hsa052310.34428159

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