ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sequestering of actin monomers (GO:0042989)	5.41945098
2	protein heterotrimerization (GO:0070208)	5.28617559
3	positive regulation of catecholamine secretion (GO:0033605)	4.73656708
4	positive regulation of mitochondrial fission (GO:0090141)	4.21274526
5	head development (GO:0060322)	4.18908519
6	peptidyl-arginine omega-N-methylation (GO:0035247)	4.15184067
7	peptidyl-arginine N-methylation (GO:0035246)	4.10396726
8	peptidyl-arginine methylation (GO:0018216)	4.10396726
9	axon extension involved in axon guidance (GO:0048846)	3.92189324
10	neuron projection extension involved in neuron projection guidance (GO:1902284)	3.92189324
11	cell adhesion mediated by integrin (GO:0033627)	3.90033887
12	protein polyglutamylation (GO:0018095)	3.89343696
13	collagen fibril organization (GO:0030199)	3.84130518
14	bone trabecula formation (GO:0060346)	3.81356275
15	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.69319671
16	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.69319671
17	negative regulation of axon guidance (GO:1902668)	3.66101248
18	negative regulation of nitric-oxide synthase activity (GO:0051001)	3.64021429
19	negative regulation of JAK-STAT cascade (GO:0046426)	3.60542473
20	kidney mesenchyme development (GO:0072074)	3.52617926
21	protein retention in ER lumen (GO:0006621)	3.46042128
22	negative regulation of axon extension involved in axon guidance (GO:0048843)	3.45890647
23	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.41765692
24	metanephric mesenchyme development (GO:0072075)	3.39225985
25	protein deneddylation (GO:0000338)	3.36955877
26	mesenchymal-epithelial cell signaling (GO:0060638)	3.36375882
27	COPI coating of Golgi vesicle (GO:0048205)	3.36029517
28	Golgi transport vesicle coating (GO:0048200)	3.36029517
29	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.33067552
30	cullin deneddylation (GO:0010388)	3.32653877
31	iron-sulfur cluster assembly (GO:0016226)	3.29855638
32	metallo-sulfur cluster assembly (GO:0031163)	3.29855638
33	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	3.24582530
34	dermatan sulfate metabolic process (GO:0030205)	3.19023741
35	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.18106417
36	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.16404775
37	substrate-dependent cell migration (GO:0006929)	3.05411418
38	wound healing, spreading of epidermal cells (GO:0035313)	3.04321100
39	germ cell migration (GO:0008354)	3.02930552
40	type B pancreatic cell proliferation (GO:0044342)	2.99316986
41	regulation of penile erection (GO:0060405)	2.97718778
42	muscle cell migration (GO:0014812)	2.96459445
43	dermatan sulfate biosynthetic process (GO:0030208)	2.95151437
44	myelin assembly (GO:0032288)	2.92626142
45	cilium morphogenesis (GO:0060271)	2.91641126
46	cranial nerve morphogenesis (GO:0021602)	2.91388696
47	protein ADP-ribosylation (GO:0006471)	2.85351371
48	protein localization to peroxisome (GO:0072662)	2.85332216
49	protein targeting to peroxisome (GO:0006625)	2.85332216
50	establishment of protein localization to peroxisome (GO:0072663)	2.85332216
51	platelet dense granule organization (GO:0060155)	2.83614782
52	seminiferous tubule development (GO:0072520)	2.83414618
53	histone arginine methylation (GO:0034969)	2.82940678
54	negative regulation of smooth muscle cell migration (GO:0014912)	2.82617882
55	spermatid nucleus differentiation (GO:0007289)	2.82555653
56	regulation of mitochondrial fission (GO:0090140)	2.82509522
57	peroxisome fission (GO:0016559)	2.81898051
58	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.81714654
59	mannosylation (GO:0097502)	2.80875085
60	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.79893522
61	DNA damage response, detection of DNA damage (GO:0042769)	2.79659848
62	lipopolysaccharide metabolic process (GO:0008653)	2.78253793
63	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.78206148
64	pyrimidine dimer repair (GO:0006290)	2.75706488
65	cornea development in camera-type eye (GO:0061303)	2.74750277
66	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.72731637
67	organ induction (GO:0001759)	2.72400434
68	pyrimidine nucleobase catabolic process (GO:0006208)	2.72195195
69	embryonic skeletal joint morphogenesis (GO:0060272)	2.71822493
70	lipopolysaccharide biosynthetic process (GO:0009103)	2.70380608
71	protein localization to cell surface (GO:0034394)	2.68782060
72	limb bud formation (GO:0060174)	2.68758111
73	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.68600174
74	facial nerve structural organization (GO:0021612)	2.68425584
75	retinal rod cell development (GO:0046548)	2.67185004
76	negative regulation of neurological system process (GO:0031645)	2.66444913
77	extracellular matrix assembly (GO:0085029)	2.65767316
78	postsynaptic membrane organization (GO:0001941)	2.65631759
79	response to UV-B (GO:0010224)	2.62636268
80	positive regulation of receptor biosynthetic process (GO:0010870)	2.61620370
81	collagen metabolic process (GO:0032963)	2.61538513
82	ubiquinone metabolic process (GO:0006743)	2.60375963
83	ganglion development (GO:0061548)	2.58913957
84	skin morphogenesis (GO:0043589)	2.58020307
85	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.57036567
86	regulation of development, heterochronic (GO:0040034)	2.56785038
87	glial cell migration (GO:0008347)	2.56398304
88	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.54630138
89	cell wall macromolecule catabolic process (GO:0016998)	2.54149452
90	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	2.53720393
91	collagen catabolic process (GO:0030574)	2.53296480
92	intraciliary transport (GO:0042073)	2.53155119
93	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	2.52584083
94	peroxisomal transport (GO:0043574)	2.51877094
95	peroxisome organization (GO:0007031)	2.51462476
96	base-excision repair, AP site formation (GO:0006285)	2.49470695
97	chondroitin sulfate catabolic process (GO:0030207)	2.48577219
98	snRNA processing (GO:0016180)	2.47418239
99	epithelial cilium movement (GO:0003351)	2.47331867
100	heparan sulfate proteoglycan biosynthetic process (GO:0015012)	2.46706052

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.93507273
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.17496236
3	WT1_19549856_ChIP-ChIP_CCG9911_Human	3.83660552
4	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.40404252
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.07931463
6	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	3.02064037
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.85011530
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.68553014
9	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.48168960
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.38667928
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.38353380
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.35576632
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.29752701
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.28763957
15	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.28309602
16	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.24516907
17	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	2.19405697
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.92495024
19	FUS_26573619_Chip-Seq_HEK293_Human	1.90463619
20	BRD4_25478319_ChIP-Seq_HGPS_Human	1.90407258
21	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.88855536
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.88730206
23	DCP1A_22483619_ChIP-Seq_HELA_Human	1.85781928
24	CJUN_26792858_Chip-Seq_BT549_Human	1.80722613
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.79222628
26	GABP_19822575_ChIP-Seq_HepG2_Human	1.77233676
27	TP53_18474530_ChIP-ChIP_U2OS_Human	1.75517804
28	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.74759426
29	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.67942460
30	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.66644569
31	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.64817305
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.64020880
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.63158725
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61896733
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.58316280
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57728605
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.55184576
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.53267288
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53267288
40	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.50126760
41	TP53_22127205_ChIP-Seq_IMR90_Human	1.49707766
42	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.48313860
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.48055612
44	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.47592921
45	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.44750541
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.41215666
47	CIITA_25753668_ChIP-Seq_RAJI_Human	1.40945224
48	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.40843524
49	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.40226734
50	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.39968659
51	EWS_26573619_Chip-Seq_HEK293_Human	1.38808464
52	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.38677024
53	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.37509156
54	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.34782805
55	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.33460325
56	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.32999000
57	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.28942692
58	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.28146468
59	SA1_22415368_ChIP-Seq_MEFs_Mouse	1.26342632
60	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.20538674
61	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.19565498
62	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.19302645
63	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.18338238
64	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.18006842
65	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.17597846
66	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.13509279
67	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.13152848
68	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.11365027
69	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.11321628
70	RXR_22108803_ChIP-Seq_LS180_Human	1.10110680
71	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.09506424
72	FOXP3_21729870_ChIP-Seq_TREG_Human	1.08457271
73	P300_19829295_ChIP-Seq_ESCs_Human	1.08403437
74	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.06818111
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05251972
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04101010
77	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.01040031
78	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00019359
79	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.00006529
80	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.99992373
81	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99812853
82	PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human	0.98882190
83	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98477948
84	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.97091756
85	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.96554821
86	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.95946257
87	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.95596836
88	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.94928883
89	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93926788
90	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.92819188
91	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.91842850
92	TTF2_22483619_ChIP-Seq_HELA_Human	0.91381943
93	XRN2_22483619_ChIP-Seq_HELA_Human	0.90880679
94	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.90362819
95	RAC3_21632823_ChIP-Seq_H3396_Human	0.90111785
96	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.89369610
97	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.89214821
98	AR_20517297_ChIP-Seq_VCAP_Human	0.88589146
99	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.88557904
100	ER_23166858_ChIP-Seq_MCF-7_Human	0.87404783

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008438_abnormal_cutaneous_collagen	5.66698321
2	MP0004272_abnormal_basement_membrane	4.27355504
3	MP0002102_abnormal_ear_morphology	3.72202251
4	MP0010368_abnormal_lymphatic_system	3.59478811
5	MP0005503_abnormal_tendon_morphology	3.21732708
6	MP0003279_aneurysm	2.78322739
7	MP0006054_spinal_hemorrhage	2.63124681
8	MP0000013_abnormal_adipose_tissue	2.52430874
9	MP0006072_abnormal_retinal_apoptosis	2.49056521
10	MP0009384_cardiac_valve_regurgitation	2.46586983
11	MP0001958_emphysema	2.32979751
12	MP0008789_abnormal_olfactory_epithelium	2.30682080
13	MP0001299_abnormal_eye_distance/	2.28384272
14	MP0005394_taste/olfaction_phenotype	2.24555336
15	MP0005499_abnormal_olfactory_system	2.24555336
16	MP0005275_abnormal_skin_tensile	2.17959694
17	MP0005623_abnormal_meninges_morphology	2.17796005
18	MP0005075_abnormal_melanosome_morpholog	2.15751166
19	MP0004147_increased_porphyrin_level	2.14596544
20	MP0001542_abnormal_bone_strength	2.13854453
21	MP0003122_maternal_imprinting	2.09173024
22	MP0001529_abnormal_vocalization	1.96329879
23	MP0006276_abnormal_autonomic_nervous	1.91423156
24	MP0005171_absent_coat_pigmentation	1.86020705
25	MP0002822_catalepsy	1.85724019
26	MP0000049_abnormal_middle_ear	1.75267769
27	MP0005257_abnormal_intraocular_pressure	1.71536574
28	MP0010386_abnormal_urinary_bladder	1.70153576
29	MP0005508_abnormal_skeleton_morphology	1.69653236
30	MP0002751_abnormal_autonomic_nervous	1.66151985
31	MP0002234_abnormal_pharynx_morphology	1.60357578
32	MP0002233_abnormal_nose_morphology	1.48619308
33	MP0005253_abnormal_eye_physiology	1.47384298
34	MP0002177_abnormal_outer_ear	1.39073490
35	MP0003315_abnormal_perineum_morphology	1.37095711
36	MP0000751_myopathy	1.34872737
37	MP0009697_abnormal_copulation	1.30557614
38	MP0003385_abnormal_body_wall	1.28087047
39	MP0010030_abnormal_orbit_morphology	1.26840688
40	MP0000569_abnormal_digit_pigmentation	1.26547785
41	MP0001243_abnormal_dermal_layer	1.24420859
42	MP0003942_abnormal_urinary_system	1.23653743
43	MP0009250_abnormal_appendicular_skeleto	1.23402521
44	MP0001984_abnormal_olfaction	1.23093609
45	MP0005391_vision/eye_phenotype	1.18634679
46	MP0000372_irregular_coat_pigmentation	1.17164075
47	MP0008004_abnormal_stomach_pH	1.14460432
48	MP0002282_abnormal_trachea_morphology	1.13942075
49	MP0001270_distended_abdomen	1.13377188
50	MP0002254_reproductive_system_inflammat	1.12919282
51	MP0000163_abnormal_cartilage_morphology	1.09580367
52	MP0003937_abnormal_limbs/digits/tail_de	1.04737809
53	MP0004510_myositis	0.98895653
54	MP0001293_anophthalmia	0.98836407
55	MP0002932_abnormal_joint_morphology	0.97814897
56	MP0002933_joint_inflammation	0.97154113
57	MP0005595_abnormal_vascular_smooth	0.97044480
58	MP0004133_heterotaxia	0.96592573
59	MP0001879_abnormal_lymphatic_vessel	0.95515852
60	MP0002295_abnormal_pulmonary_circulatio	0.93806044
61	MP0005360_urolithiasis	0.92771739
62	MP0004142_abnormal_muscle_tone	0.91311373
63	MP0002092_abnormal_eye_morphology	0.90576423
64	MP0004858_abnormal_nervous_system	0.89105558
65	MP0002113_abnormal_skeleton_development	0.87677994
66	MP0002115_abnormal_skeleton_extremities	0.86606600
67	MP0001348_abnormal_lacrimal_gland	0.85446481
68	MP0003755_abnormal_palate_morphology	0.82925072
69	MP0002697_abnormal_eye_size	0.81411829
70	MP0004859_abnormal_synaptic_plasticity	0.79810401
71	MP0000778_abnormal_nervous_system	0.79745233
72	MP0002877_abnormal_melanocyte_morpholog	0.79243810
73	MP0003880_abnormal_central_pattern	0.79233916
74	MP0002896_abnormal_bone_mineralization	0.78939924
75	MP0000358_abnormal_cell_content/	0.78374241
76	MP0002109_abnormal_limb_morphology	0.76999793
77	MP0004197_abnormal_fetal_growth/weight/	0.76758903
78	MP0001340_abnormal_eyelid_morphology	0.75682001
79	MP0003091_abnormal_cell_migration	0.75375561
80	MP0003221_abnormal_cardiomyocyte_apopto	0.74691401
81	MP0000767_abnormal_smooth_muscle	0.74486703
82	MP0001905_abnormal_dopamine_level	0.73332932
83	MP0002752_abnormal_somatic_nervous	0.72652629
84	MP0005410_abnormal_fertilization	0.72094240
85	MP0002653_abnormal_ependyma_morphology	0.70974847
86	MP0000026_abnormal_inner_ear	0.70211067
87	MP0005551_abnormal_eye_electrophysiolog	0.69908635
88	MP0000465_gastrointestinal_hemorrhage	0.69532703
89	MP0005197_abnormal_uvea_morphology	0.69031981
90	MP0000749_muscle_degeneration	0.68906149
91	MP0003136_yellow_coat_color	0.68489925
92	MP0002060_abnormal_skin_morphology	0.67534364
93	MP0000534_abnormal_ureter_morphology	0.67037905
94	MP0002116_abnormal_craniofacial_bone	0.66965693
95	MP0004134_abnormal_chest_morphology	0.65498938
96	MP0005193_abnormal_anterior_eye	0.62707440
97	MP0003121_genomic_imprinting	0.61625798
98	MP0002938_white_spotting	0.61589994
99	MP0001764_abnormal_homeostasis	0.61516409
100	MP0002114_abnormal_axial_skeleton	0.61273077

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature rupture of membranes (HP:0001788)	5.18386853
2	Ankle contracture (HP:0006466)	4.56809183
3	Protrusio acetabuli (HP:0003179)	4.22462125
4	Abnormality of dentin (HP:0010299)	3.78353536
5	Cervical subluxation (HP:0003308)	3.63198944
6	Spinal rigidity (HP:0003306)	3.36384377
7	Follicular hyperkeratosis (HP:0007502)	3.34876402
8	Adactyly (HP:0009776)	3.26140498
9	Hypoventilation (HP:0002791)	3.05322983
10	Aortic dissection (HP:0002647)	3.05274291
11	Vitreoretinal degeneration (HP:0000655)	3.01983840
12	Retinal dysplasia (HP:0007973)	2.87172912
13	Aortic aneurysm (HP:0004942)	2.80341704
14	Distal arthrogryposis (HP:0005684)	2.79673177
15	Medial flaring of the eyebrow (HP:0010747)	2.62712080
16	Bladder diverticulum (HP:0000015)	2.59487649
17	Congenital primary aphakia (HP:0007707)	2.53865362
18	Decreased skull ossification (HP:0004331)	2.53223697
19	Increased corneal curvature (HP:0100692)	2.50024836
20	Keratoconus (HP:0000563)	2.50024836
21	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.49027529
22	Abnormal protein N-linked glycosylation (HP:0012347)	2.49027529
23	Abnormal protein glycosylation (HP:0012346)	2.49027529
24	Abnormal glycosylation (HP:0012345)	2.49027529
25	Atrophic scars (HP:0001075)	2.44893811
26	True hermaphroditism (HP:0010459)	2.40146442
27	Gait imbalance (HP:0002141)	2.38560362
28	Abnormality of skull ossification (HP:0002703)	2.37892996
29	Sclerocornea (HP:0000647)	2.37821329
30	Amyotrophic lateral sclerosis (HP:0007354)	2.37173983
31	Soft skin (HP:0000977)	2.35483831
32	Nephrogenic diabetes insipidus (HP:0009806)	2.33160194
33	Pancreatic fibrosis (HP:0100732)	2.29638783
34	Vertebral compression fractures (HP:0002953)	2.29342416
35	Type II lissencephaly (HP:0007260)	2.28762578
36	Neonatal short-limb short stature (HP:0008921)	2.27587894
37	Short tibia (HP:0005736)	2.27153423
38	Axonal loss (HP:0003447)	2.26237466
39	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.23239950
40	Hypoplasia of the brainstem (HP:0002365)	2.23239950
41	Hand muscle atrophy (HP:0009130)	2.22720980
42	Occipital encephalocele (HP:0002085)	2.21997886
43	Wormian bones (HP:0002645)	2.21029112
44	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.19171053
45	Narrow nasal bridge (HP:0000446)	2.15716520
46	Peripheral hypomyelination (HP:0007182)	2.14342212
47	Cerebellar dysplasia (HP:0007033)	2.11463947
48	Failure to thrive in infancy (HP:0001531)	2.10883525
49	Neonatal respiratory distress (HP:0002643)	2.10556098
50	Limb-girdle muscle weakness (HP:0003325)	2.08280450
51	Upper limb muscle weakness (HP:0003484)	2.08241342
52	Hypoplasia of the iris (HP:0007676)	2.06746644
53	Upper limb amyotrophy (HP:0009129)	2.05668260
54	Distal upper limb amyotrophy (HP:0007149)	2.05668260
55	Congenital stationary night blindness (HP:0007642)	2.04344549
56	Biconcave vertebral bodies (HP:0004586)	2.03379659
57	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.02823132
58	Genu recurvatum (HP:0002816)	2.01586729
59	Morphological abnormality of the middle ear (HP:0008609)	2.00864322
60	Abnormality of the musculature of the pelvis (HP:0001469)	2.00784724
61	Abnormality of the hip-girdle musculature (HP:0001445)	2.00784724
62	Fibular hypoplasia (HP:0003038)	1.99919658
63	Limb-girdle muscle atrophy (HP:0003797)	1.99366217
64	Broad alveolar ridges (HP:0000187)	1.98932156
65	Postaxial hand polydactyly (HP:0001162)	1.97082873
66	Postaxial foot polydactyly (HP:0001830)	1.95911674
67	Abnormality of the anterior chamber (HP:0000593)	1.95866599
68	Delayed gross motor development (HP:0002194)	1.93405978
69	Pachygyria (HP:0001302)	1.92488573
70	Renal cortical cysts (HP:0000803)	1.92271531
71	Wrist flexion contracture (HP:0001239)	1.91855392
72	Pancreatic cysts (HP:0001737)	1.91329158
73	Type 1 muscle fiber predominance (HP:0003803)	1.89296090
74	Shoulder girdle muscle weakness (HP:0003547)	1.89051980
75	Aortic regurgitation (HP:0001659)	1.88405490
76	Bowel diverticulosis (HP:0005222)	1.87316435
77	Joint stiffness (HP:0001387)	1.87040922
78	High anterior hairline (HP:0009890)	1.85918577
79	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.85703055
80	Anterior segment dysgenesis (HP:0007700)	1.85337854
81	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.84645238
82	Aplasia/Hypoplasia of the clavicles (HP:0006710)	1.83369916
83	Aplasia/Hypoplasia of the lens (HP:0008063)	1.80907900
84	Vascular tortuosity (HP:0004948)	1.80904125
85	Broad foot (HP:0001769)	1.80423616
86	Elbow flexion contracture (HP:0002987)	1.79813047
87	Flattened epiphyses (HP:0003071)	1.79521712
88	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.79254650
89	Absent epiphyses (HP:0010577)	1.79254650
90	Thyroid-stimulating hormone excess (HP:0002925)	1.78782428
91	Hyperglycinemia (HP:0002154)	1.78014518
92	Wide anterior fontanel (HP:0000260)	1.75718829
93	Ectopia lentis (HP:0001083)	1.74571210
94	Deformed tarsal bones (HP:0008119)	1.74356615
95	Aortic valve stenosis (HP:0001650)	1.74101411
96	Hypoplastic pelvis (HP:0008839)	1.73239333
97	Molar tooth sign on MRI (HP:0002419)	1.71659721
98	Abnormality of midbrain morphology (HP:0002418)	1.71659721
99	Increased variability in muscle fiber diameter (HP:0003557)	1.71601934
100	Decreased testicular size (HP:0008734)	1.68381945

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.68227613
2	PINK1	3.85755794
3	TXK	3.17614672
4	MAP2K7	3.00272876
5	BCR	2.90041473
6	MOS	2.64186031
7	BCKDK	2.43442507
8	FLT3	2.28864318
9	CSNK1G3	2.27302240
10	CSNK1A1L	2.26326043
11	KIT	1.97313594
12	NEK2	1.94898694
13	DDR2	1.92800721
14	MARK3	1.90849174
15	GRK7	1.90390118
16	EPHB1	1.89890327
17	CSNK1G2	1.88223676
18	DYRK3	1.84964767
19	MYLK	1.82347668
20	ERBB3	1.80857049
21	TRIM28	1.74251880
22	TGFBR2	1.70364253
23	RPS6KA4	1.70025377
24	CSNK1G1	1.69922381
25	KDR	1.67777427
26	CDK19	1.61175610
27	MAP3K4	1.57079010
28	MAPK15	1.53266190
29	TESK1	1.40643436
30	LIMK1	1.40603050
31	LATS1	1.38579666
32	TGFBR1	1.27997168
33	MAP3K5	1.27470510
34	EPHB2	1.24996131
35	ADRBK2	1.20110059
36	PLK2	1.20068747
37	SIK3	1.16850705
38	NEK9	1.16197398
39	EPHA3	1.14850800
40	ZAK	1.09553719
41	PDGFRA	1.06989708
42	GRK1	1.03685313
43	PAK2	1.02440743
44	VRK2	1.01215490
45	SRPK1	0.97980784
46	MARK1	0.93533523
47	BMPR1B	0.93203223
48	EIF2AK3	0.92367465
49	PIM2	0.91136283
50	GRK5	0.88951649
51	SIK2	0.88436016
52	PRKD2	0.87558684
53	DYRK1B	0.85311307
54	VRK1	0.82621403
55	NUAK1	0.80423700
56	PAK6	0.78038046
57	STK38L	0.73956473
58	WNK3	0.72941877
59	ADRBK1	0.72019323
60	DYRK2	0.71997250
61	CDK14	0.70192362
62	GRK6	0.69688617
63	TESK2	0.68870429
64	CDK9	0.67302026
65	CDK8	0.67088290
66	RPS6KA5	0.62676701
67	KSR1	0.62277071
68	NTRK1	0.59796919
69	MAP3K6	0.58690591
70	CDK3	0.58333070
71	MAP3K11	0.58289040
72	ERN1	0.55593055
73	STK38	0.54435413
74	TIE1	0.52658089
75	ERBB4	0.49291587
76	PRKCE	0.48678562
77	PTK2B	0.47412392
78	CDK6	0.44700975
79	MAPK13	0.42903955
80	CDK18	0.40650023
81	CDK11A	0.39074675
82	DAPK3	0.38058795
83	MAP2K4	0.36673103
84	AURKA	0.36553008
85	TAOK3	0.34277830
86	NEK1	0.34042414
87	CDK15	0.33607013
88	IGF1R	0.32465887
89	PLK4	0.32188553
90	CSNK1A1	0.30947610
91	MUSK	0.30278405
92	TBK1	0.29691041
93	MAP3K12	0.28978629
94	UHMK1	0.28813235
95	PAK4	0.27940141
96	CSF1R	0.24936573
97	AURKB	0.24013280
98	DAPK1	0.23625397
99	ABL1	0.23496048
100	CCNB1	0.23298134

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	4.24150703
2	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	3.00365029
3	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.73681302
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.72016783
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.47347760
6	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.42442089
7	Phototransduction_Homo sapiens_hsa04744	2.40691452
8	ECM-receptor interaction_Homo sapiens_hsa04512	2.27600056
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.24668139
10	Protein export_Homo sapiens_hsa03060	2.02038363
11	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.97236111
12	Basal cell carcinoma_Homo sapiens_hsa05217	1.78707548
13	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.72346427
14	Axon guidance_Homo sapiens_hsa04360	1.68876098
15	Base excision repair_Homo sapiens_hsa03410	1.67646902
16	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.65111199
17	RNA polymerase_Homo sapiens_hsa03020	1.63793576
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.57448915
19	Protein digestion and absorption_Homo sapiens_hsa04974	1.55689898
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.51306323
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.50404158
22	Phagosome_Homo sapiens_hsa04145	1.44605332
23	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.43517072
24	Vibrio cholerae infection_Homo sapiens_hsa05110	1.40316770
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.38970380
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.36383774
27	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.36103016
28	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.33993504
29	Other glycan degradation_Homo sapiens_hsa00511	1.31494670
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.30017512
31	Hippo signaling pathway_Homo sapiens_hsa04390	1.28848623
32	Regulation of autophagy_Homo sapiens_hsa04140	1.27191174
33	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.26846529
34	Shigellosis_Homo sapiens_hsa05131	1.25105282
35	Focal adhesion_Homo sapiens_hsa04510	1.18200490
36	Butanoate metabolism_Homo sapiens_hsa00650	1.17489439
37	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.15250523
38	Peroxisome_Homo sapiens_hsa04146	1.13628073
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12990815
40	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.11024539
41	Basal transcription factors_Homo sapiens_hsa03022	1.05476457
42	Spliceosome_Homo sapiens_hsa03040	1.05359649
43	Olfactory transduction_Homo sapiens_hsa04740	1.04671298
44	Fatty acid elongation_Homo sapiens_hsa00062	1.03161780
45	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	1.01067495
46	Antigen processing and presentation_Homo sapiens_hsa04612	1.00710786
47	Rheumatoid arthritis_Homo sapiens_hsa05323	0.99251483
48	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.97141468
49	Steroid biosynthesis_Homo sapiens_hsa00100	0.95220650
50	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.91977475
51	Gap junction_Homo sapiens_hsa04540	0.90580516
52	Glutathione metabolism_Homo sapiens_hsa00480	0.90120850
53	GABAergic synapse_Homo sapiens_hsa04727	0.89874562
54	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.89605936
55	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.89267219
56	Purine metabolism_Homo sapiens_hsa00230	0.88815530
57	Viral myocarditis_Homo sapiens_hsa05416	0.80585023
58	Salmonella infection_Homo sapiens_hsa05132	0.80455344
59	Taste transduction_Homo sapiens_hsa04742	0.72833165
60	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.72178169
61	RNA degradation_Homo sapiens_hsa03018	0.71161652
62	Proteasome_Homo sapiens_hsa03050	0.69824357
63	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.69657596
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67315698
65	Renin-angiotensin system_Homo sapiens_hsa04614	0.67168149
66	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.65419507
67	p53 signaling pathway_Homo sapiens_hsa04115	0.65409180
68	Malaria_Homo sapiens_hsa05144	0.63889494
69	Nicotine addiction_Homo sapiens_hsa05033	0.63766874
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.62622287
71	Small cell lung cancer_Homo sapiens_hsa05222	0.62576297
72	Oxidative phosphorylation_Homo sapiens_hsa00190	0.62294332
73	Wnt signaling pathway_Homo sapiens_hsa04310	0.61906295
74	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.61264289
75	Melanogenesis_Homo sapiens_hsa04916	0.61171882
76	Endocytosis_Homo sapiens_hsa04144	0.59390386
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.59100529
78	Propanoate metabolism_Homo sapiens_hsa00640	0.57955080
79	Alcoholism_Homo sapiens_hsa05034	0.57883335
80	Parkinsons disease_Homo sapiens_hsa05012	0.55995226
81	Pathways in cancer_Homo sapiens_hsa05200	0.54507307
82	RNA transport_Homo sapiens_hsa03013	0.52749483
83	Cocaine addiction_Homo sapiens_hsa05030	0.48066590
84	mRNA surveillance pathway_Homo sapiens_hsa03015	0.47592922
85	Non-homologous end-joining_Homo sapiens_hsa03450	0.46578003
86	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.44741013
87	Selenocompound metabolism_Homo sapiens_hsa00450	0.43858734
88	Sulfur metabolism_Homo sapiens_hsa00920	0.43641267
89	Apoptosis_Homo sapiens_hsa04210	0.43328829
90	Salivary secretion_Homo sapiens_hsa04970	0.42510963
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.42498832
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.42340452
93	Metabolic pathways_Homo sapiens_hsa01100	0.42143960
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40804027
95	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.36938858
96	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.32431438
97	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.29770897
98	Lysosome_Homo sapiens_hsa04142	0.29710459
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.29467714
100	HTLV-I infection_Homo sapiens_hsa05166	0.27691569

RCN1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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