RCOR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chromatin binding (GO:0035561)4.51073769
2response to peptidoglycan (GO:0032494)4.09043206
3ribosomal small subunit assembly (GO:0000028)4.02746469
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84943619
5positive regulation by organism of defense response of other organism involved in symbiotic interact3.84943619
6modulation by symbiont of host immune response (GO:0052553)3.84943619
7positive regulation by symbiont of host defense response (GO:0052509)3.84943619
8modulation by symbiont of host defense response (GO:0052031)3.84943619
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84943619
10histone H3-K36 demethylation (GO:0070544)3.52212448
11hypotonic response (GO:0006971)3.49316232
12viral transcription (GO:0019083)3.34381400
13definitive hemopoiesis (GO:0060216)3.34192523
14embryonic process involved in female pregnancy (GO:0060136)3.30497314
15mitotic sister chromatid cohesion (GO:0007064)3.28689293
16translational termination (GO:0006415)3.27758426
17neutrophil activation involved in immune response (GO:0002283)3.26610185
18cellular extravasation (GO:0045123)3.25051976
19protein localization to kinetochore (GO:0034501)3.23554606
20response to muramyl dipeptide (GO:0032495)3.19346018
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.17798155
22detection of other organism (GO:0098543)3.17641182
23protein localization to chromosome, centromeric region (GO:0071459)3.07781973
24histone H3-K9 demethylation (GO:0033169)3.06613498
25dosage compensation (GO:0007549)3.05253913
26detection of molecule of bacterial origin (GO:0032490)3.04860577
27positive regulation of B cell differentiation (GO:0045579)3.02978421
283-UTR-mediated mRNA stabilization (GO:0070935)3.00868344
29regulation of RNA export from nucleus (GO:0046831)2.98043459
30maturation of SSU-rRNA (GO:0030490)2.97250546
31erythrocyte maturation (GO:0043249)2.93911613
32DNA unwinding involved in DNA replication (GO:0006268)2.93383382
33megakaryocyte development (GO:0035855)2.93006370
34mitotic nuclear envelope disassembly (GO:0007077)2.92808927
35protein localization to chromosome (GO:0034502)2.92420572
36positive regulation of Cdc42 GTPase activity (GO:0043089)2.92311582
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.91811228
38positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91352381
39iron ion import (GO:0097286)2.88673705
40translational elongation (GO:0006414)2.87105667
41histone lysine demethylation (GO:0070076)2.87033940
42hepatocyte apoptotic process (GO:0097284)2.86468471
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.85518943
44response to host (GO:0075136)2.85518943
45response to host defenses (GO:0052200)2.85518943
46detection of bacterium (GO:0016045)2.84829350
47mitotic chromosome condensation (GO:0007076)2.84457413
48macrophage activation involved in immune response (GO:0002281)2.83425545
49positive regulation of gamma-delta T cell activation (GO:0046645)2.82773109
50nuclear pore complex assembly (GO:0051292)2.81473725
51monoubiquitinated protein deubiquitination (GO:0035520)2.81437730
52translesion synthesis (GO:0019985)2.79756552
53detection of external biotic stimulus (GO:0098581)2.78501121
54positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.78481666
55epithelial cell differentiation involved in prostate gland development (GO:0060742)2.77713187
56translational initiation (GO:0006413)2.75637795
57histone demethylation (GO:0016577)2.75178232
58membrane disassembly (GO:0030397)2.74516061
59nuclear envelope disassembly (GO:0051081)2.74516061
60response to laminar fluid shear stress (GO:0034616)2.74341629
61desmosome organization (GO:0002934)2.74206575
62SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.73817211
63negative regulation of RNA splicing (GO:0033119)2.72610096
64pore complex assembly (GO:0046931)2.72110904
65formation of translation preinitiation complex (GO:0001731)2.71612650
66response to host immune response (GO:0052572)2.71490461
67response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.71490461
68protein localization to endosome (GO:0036010)2.70138534
69lipopolysaccharide-mediated signaling pathway (GO:0031663)2.67836688
70regulation of leukocyte degranulation (GO:0043300)2.67518990
71negative regulation of DNA repair (GO:0045738)2.67017402
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.66543057
73embryonic hemopoiesis (GO:0035162)2.64790846
74hemidesmosome assembly (GO:0031581)2.63858420
75glucocorticoid receptor signaling pathway (GO:0042921)2.63565311
76protein targeting to ER (GO:0045047)2.63525150
77nuclear pore organization (GO:0006999)2.63020717
78regulation of gamma-delta T cell differentiation (GO:0045586)2.61823251
79regulation of spindle organization (GO:0090224)2.61591857
80regulation of NFAT protein import into nucleus (GO:0051532)2.61182985
81cotranslational protein targeting to membrane (GO:0006613)2.60541915
82RNA stabilization (GO:0043489)2.59761613
83mRNA stabilization (GO:0048255)2.59761613
84regulation of double-strand break repair via homologous recombination (GO:0010569)2.59176902
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.59110458
86antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.59110458
87regulation of interferon-beta biosynthetic process (GO:0045357)2.58773448
88negative regulation of histone methylation (GO:0031061)2.57118384
89ATP-dependent chromatin remodeling (GO:0043044)2.57088791
90establishment of protein localization to endoplasmic reticulum (GO:0072599)2.57027802
91DNA replication checkpoint (GO:0000076)2.56852113
92telomere maintenance via semi-conservative replication (GO:0032201)2.55246810
93olfactory bulb development (GO:0021772)2.54747190
94viral life cycle (GO:0019058)2.54548303
95positive regulation of mitotic sister chromatid separation (GO:1901970)2.53530436
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.53530436
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.53530436
98mitotic metaphase plate congression (GO:0007080)2.53032024
99telomere maintenance via recombination (GO:0000722)2.52437717
100regulation of erythrocyte differentiation (GO:0045646)2.51791278
101regulation of MHC class II biosynthetic process (GO:0045346)2.51309249
102positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.51131685
103negative regulation of phagocytosis (GO:0050765)2.51063328
104kinetochore organization (GO:0051383)2.50810363
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.50490895
106detection of biotic stimulus (GO:0009595)2.50360540
107positive regulation of chromosome segregation (GO:0051984)2.50187512
108mitotic recombination (GO:0006312)2.49095348
109DNA replication-independent nucleosome assembly (GO:0006336)2.48592149
110DNA replication-independent nucleosome organization (GO:0034724)2.48592149
111negative regulation of erythrocyte differentiation (GO:0045647)2.47563437
112DNA strand elongation involved in DNA replication (GO:0006271)2.47511290
113corticosteroid receptor signaling pathway (GO:0031958)2.46674363
114DNA strand elongation (GO:0022616)2.45682267
115trophectodermal cell differentiation (GO:0001829)2.44454817
116DNA topological change (GO:0006265)2.44312884
117metaphase plate congression (GO:0051310)2.44250374
118CENP-A containing nucleosome assembly (GO:0034080)2.43568819
119regulation of mast cell degranulation (GO:0043304)2.43207313
120protein localization to endoplasmic reticulum (GO:0070972)2.41788184
121negative regulation of transcription regulatory region DNA binding (GO:2000678)2.41582081
122cellular protein complex disassembly (GO:0043624)2.41412301
123negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.41323357
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.41081309
125regulation of histone H3-K9 methylation (GO:0051570)2.40958783
126peptidyl-threonine modification (GO:0018210)2.40376681
127cell-substrate junction assembly (GO:0007044)2.39519906
128protein dealkylation (GO:0008214)2.39239304
129protein demethylation (GO:0006482)2.39239304
130regulation of sister chromatid cohesion (GO:0007063)2.38908747
131leukocyte aggregation (GO:0070486)2.38718108
132regulation of histone H3-K27 methylation (GO:0061085)2.38226927
133DNA replication initiation (GO:0006270)2.37783801
134chromatin assembly or disassembly (GO:0006333)2.37232031
135positive regulation of cellular amide metabolic process (GO:0034250)2.36733003
136nuclear-transcribed mRNA catabolic process (GO:0000956)2.36317576
137peptidyl-threonine phosphorylation (GO:0018107)2.36010224
138natural killer cell mediated cytotoxicity (GO:0042267)2.35880816
139natural killer cell mediated immunity (GO:0002228)2.35880816
140antigen processing and presentation via MHC class Ib (GO:0002475)2.35347750
141eyelid development in camera-type eye (GO:0061029)2.35142185
142cytoplasmic mRNA processing body assembly (GO:0033962)2.34359883
143ribosomal small subunit biogenesis (GO:0042274)2.34345817
144regulation of gamma-delta T cell activation (GO:0046643)2.33899437
145neutrophil activation (GO:0042119)2.33839097
146Arp2/3 complex-mediated actin nucleation (GO:0034314)2.33814033
147protein complex disassembly (GO:0043241)2.33692880
148mammary gland epithelial cell proliferation (GO:0033598)2.33502645
149skin morphogenesis (GO:0043589)2.32743706
150T cell apoptotic process (GO:0070231)2.32205396
151protein export from nucleus (GO:0006611)2.31633489
152bundle of His cell to Purkinje myocyte communication (GO:0086069)2.31436548
153regulation of nucleobase-containing compound transport (GO:0032239)2.30883191
154regulation of myeloid leukocyte mediated immunity (GO:0002886)2.30718465
155regulation of early endosome to late endosome transport (GO:2000641)2.30290806
156DNA duplex unwinding (GO:0032508)2.30150705
157histone H3-K4 trimethylation (GO:0080182)2.30041240
158positive regulation of erythrocyte differentiation (GO:0045648)2.29946180
159response to UV-C (GO:0010225)2.29790910
160regulation of water loss via skin (GO:0033561)2.29635899
161nuclear envelope organization (GO:0006998)2.29138596
162mRNA catabolic process (GO:0006402)2.28773529
163granulocyte activation (GO:0036230)2.27503336
164positive regulation of leukocyte degranulation (GO:0043302)2.26706192
165positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.25720541
166mRNA transcription (GO:0009299)2.25206733
167activation of Rac GTPase activity (GO:0032863)2.23761600
168focal adhesion assembly (GO:0048041)2.22281237
169cell-substrate adherens junction assembly (GO:0007045)2.22281237
170protein localization to microtubule (GO:0035372)2.21742182
171germinal center formation (GO:0002467)2.21317529
172JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.21068732
173regulation of mast cell activation involved in immune response (GO:0033006)2.16806769
174positive regulation of keratinocyte differentiation (GO:0045618)2.15864309
175regulation of necroptotic process (GO:0060544)2.14733603
176positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.13682440
177N-terminal protein amino acid acetylation (GO:0006474)2.13063615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.19543166
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.28085615
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.98505185
4MYC_22102868_ChIP-Seq_BL_Human3.02415602
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82436368
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61901137
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57298835
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.54670169
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41705700
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.36638205
11SCL_19346495_ChIP-Seq_HPC-7_Human2.28524446
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.27661138
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.23773479
14ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.21633022
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17350547
16VDR_21846776_ChIP-Seq_THP-1_Human2.12589033
17E2F1_21310950_ChIP-Seq_MCF-7_Human1.99939494
18IRF8_22096565_ChIP-ChIP_GC-B_Human1.95493790
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94109344
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93452412
21* TCF7_22412390_ChIP-Seq_EML_Mouse1.88535582
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.85823517
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78596895
24* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.70049941
25* MAF_26560356_Chip-Seq_TH1_Human1.69293062
26UTX_26944678_Chip-Seq_JUKART_Human1.69039360
27CIITA_25753668_ChIP-Seq_RAJI_Human1.68892532
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.68563485
29CLOCK_20551151_ChIP-Seq_293T_Human1.65513148
30* MYB_26560356_Chip-Seq_TH2_Human1.65130747
31VDR_24763502_ChIP-Seq_THP-1_Human1.63977630
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63493966
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.62500801
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61958971
35* SPI1_23127762_ChIP-Seq_K562_Human1.61460748
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61459454
37SPI1_23547873_ChIP-Seq_NB4_Human1.60833756
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60286268
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59262533
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59138690
41* MYB_26560356_Chip-Seq_TH1_Human1.58872160
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54923184
43* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54735902
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53251208
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.52594209
46* XRN2_22483619_ChIP-Seq_HELA_Human1.50412206
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50341235
48* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49095156
49AR_21909140_ChIP-Seq_LNCAP_Human1.49031367
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48372406
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48338153
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47866777
53ZNF263_19887448_ChIP-Seq_K562_Human1.47811632
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46804251
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46804251
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.45389912
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44885644
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44771228
59* RUNX1_22412390_ChIP-Seq_EML_Mouse1.44403925
60VDR_23849224_ChIP-Seq_CD4+_Human1.42579492
61* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41933291
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41512029
63FOXP3_21729870_ChIP-Seq_TREG_Human1.40592065
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40532565
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40488722
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38962178
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38953579
68GATA1_19941826_ChIP-Seq_K562_Human1.36985735
69* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36100323
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.35409343
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34647038
72* RACK7_27058665_Chip-Seq_MCF-7_Human1.34456768
73* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33891210
74* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31999142
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31166496
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30108607
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30108607
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30108607
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29638542
80TFEB_21752829_ChIP-Seq_HELA_Human1.28928948
81* KDM5A_27292631_Chip-Seq_BREAST_Human1.28890044
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28193589
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27620513
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27341473
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27225154
86* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26847536
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25980334
88ELK1_19687146_ChIP-ChIP_HELA_Human1.25797496
89* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24588354
90EST1_17652178_ChIP-ChIP_JURKAT_Human1.24134272
91* ELK3_25401928_ChIP-Seq_HUVEC_Human1.24092990
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22725629
93* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22217151
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21931899
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.21752074
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21497593
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20503602
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18983593
99MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18243246
100* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17397003
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17244409
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16925710
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16834757
104GATA2_19941826_ChIP-Seq_K562_Human1.16801421
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16329980
106NCOR1_26117541_ChIP-Seq_K562_Human1.16328932
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16031439
108* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16013365
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.15886758
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15437039
111CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15034806
112FOXO3_23340844_ChIP-Seq_DLD1_Human1.14601654
113DCP1A_22483619_ChIP-Seq_HELA_Human1.14600262
114* KDM2B_26808549_Chip-Seq_DND41_Human1.14223788
115ESR2_21235772_ChIP-Seq_MCF-7_Human1.12609186
116GABP_17652178_ChIP-ChIP_JURKAT_Human1.12101615
117* PU_27001747_Chip-Seq_BMDM_Mouse1.11638009
118TTF2_22483619_ChIP-Seq_HELA_Human1.09319651
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09289283
120IRF8_27001747_Chip-Seq_BMDM_Mouse1.09265118
121GATA1_22025678_ChIP-Seq_K562_Human1.08934303
122* MAF_26560356_Chip-Seq_TH2_Human1.08372124
123* RUNX1_27514584_Chip-Seq_MCF-7_Human1.08119230
124GABP_19822575_ChIP-Seq_HepG2_Human1.08035380
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08029060
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07944166
127* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06676225
128IRF8_21731497_ChIP-ChIP_J774_Mouse1.06286805
129SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06200022
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05576149
131* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04342872
132KDM2B_26808549_Chip-Seq_K562_Human1.04275540
133UBF1/2_26484160_Chip-Seq_HMECs_Human1.04182371
134SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03431884
135ATF3_27146783_Chip-Seq_COLON_Human1.02640830
136CHD1_26751641_Chip-Seq_LNCaP_Human1.02511318
137ETS1_20019798_ChIP-Seq_JURKAT_Human0.99846062
138NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98316812
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97226186
140GATA3_27048872_Chip-Seq_THYMUS_Human0.96633573
141* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95176190
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95167215

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.14199072
2MP0005451_abnormal_body_composition2.72677467
3MP0002396_abnormal_hematopoietic_system2.50838565
4MP0010352_gastrointestinal_tract_polyps2.41663406
5MP0005409_darkened_coat_color2.41271152
6MP0002796_impaired_skin_barrier2.40339164
7MP0000490_abnormal_crypts_of2.22553876
8MP0004808_abnormal_hematopoietic_stem2.18946438
9MP0003763_abnormal_thymus_physiology2.17626193
10MP0006054_spinal_hemorrhage2.16461836
11MP0002877_abnormal_melanocyte_morpholog2.09704332
12MP0003191_abnormal_cellular_cholesterol2.02969042
13MP0010094_abnormal_chromosome_stability2.02474878
14MP0003705_abnormal_hypodermis_morpholog2.02370681
15MP0008007_abnormal_cellular_replicative2.00421564
16MP0005397_hematopoietic_system_phenotyp1.98694492
17MP0001545_abnormal_hematopoietic_system1.98694492
18MP0008260_abnormal_autophagy1.95842622
19MP0003567_abnormal_fetal_cardiomyocyte1.93973540
20MP0003077_abnormal_cell_cycle1.90643201
21MP0003111_abnormal_nucleus_morphology1.88688431
22MP0004185_abnormal_adipocyte_glucose1.86304880
23MP0004957_abnormal_blastocyst_morpholog1.78717551
24MP0008789_abnormal_olfactory_epithelium1.76643004
25MP0003828_pulmonary_edema1.76505964
26MP0005076_abnormal_cell_differentiation1.72965060
27MP0003300_gastrointestinal_ulcer1.68428051
28MP0002398_abnormal_bone_marrow1.65235319
29MP0003303_peritoneal_inflammation1.64539282
30MP0005501_abnormal_skin_physiology1.55127346
31MP0010678_abnormal_skin_adnexa1.55003369
32MP0009278_abnormal_bone_marrow1.52259494
33MP0000465_gastrointestinal_hemorrhage1.49605390
34MP0000685_abnormal_immune_system1.48268281
35MP0009333_abnormal_splenocyte_physiolog1.45491126
36MP0008057_abnormal_DNA_replication1.44828116
37MP0003091_abnormal_cell_migration1.44253598
38MP0002166_altered_tumor_susceptibility1.43759702
39MP0001800_abnormal_humoral_immune1.38202607
40MP0010307_abnormal_tumor_latency1.38111543
41MP0000703_abnormal_thymus_morphology1.36720592
42MP0004381_abnormal_hair_follicle1.35672909
43MP0000350_abnormal_cell_proliferation1.35636335
44MP0003436_decreased_susceptibility_to1.35457544
45MP0002722_abnormal_immune_system1.33651029
46MP0005174_abnormal_tail_pigmentation1.33455517
47MP0001730_embryonic_growth_arrest1.31589367
48MP0002452_abnormal_antigen_presenting1.30840713
49MP0005058_abnormal_lysosome_morphology1.29940411
50MP0003566_abnormal_cell_adhesion1.29815084
51MP0005464_abnormal_platelet_physiology1.26737339
52MP0002420_abnormal_adaptive_immunity1.25243087
53MP0000383_abnormal_hair_follicle1.23756108
54MP0001819_abnormal_immune_cell1.23186577
55MP0000858_altered_metastatic_potential1.22303604
56MP0002086_abnormal_extraembryonic_tissu1.22167269
57MP0000689_abnormal_spleen_morphology1.21830736
58MP0010155_abnormal_intestine_physiology1.20990985
59MP0001293_anophthalmia1.20665868
60MP0001835_abnormal_antigen_presentation1.20217412
61MP0000716_abnormal_immune_system1.19602489
62MP0002006_tumorigenesis1.19500947
63MP0002405_respiratory_system_inflammati1.19308491
64MP0002429_abnormal_blood_cell1.18055783
65MP0003984_embryonic_growth_retardation1.16758867
66MP0002088_abnormal_embryonic_growth/wei1.15463384
67MP0001851_eye_inflammation1.15037342
68MP0005394_taste/olfaction_phenotype1.14625977
69MP0005499_abnormal_olfactory_system1.14625977
70MP0004947_skin_inflammation1.13992417
71MP0004233_abnormal_muscle_weight1.12618925
72MP0005380_embryogenesis_phenotype1.12063226
73MP0001672_abnormal_embryogenesis/_devel1.12063226
74MP0010234_abnormal_vibrissa_follicle1.11435754
75MP0008058_abnormal_DNA_repair1.11304888
76MP0001849_ear_inflammation1.10854059
77MP0000579_abnormal_nail_morphology1.10790634
78MP0002723_abnormal_immune_serum1.09984395
79MP0003724_increased_susceptibility_to1.09036671
80MP0001697_abnormal_embryo_size1.08729191
81MP0002019_abnormal_tumor_incidence1.08587628
82MP0005000_abnormal_immune_tolerance1.08127435
83MP0003656_abnormal_erythrocyte_physiolo1.07189876
84MP0003172_abnormal_lysosome_physiology1.06148912
85MP0002098_abnormal_vibrissa_morphology1.06138614
86MP0005621_abnormal_cell_physiology1.05133073
87MP0005666_abnormal_adipose_tissue1.02282401
88MP0000377_abnormal_hair_follicle1.02163610
89MP0002060_abnormal_skin_morphology1.01327702
90MP0003453_abnormal_keratinocyte_physiol1.00554954
91MP0001853_heart_inflammation0.99683253
92MP0004197_abnormal_fetal_growth/weight/0.98283232
93MP0002132_abnormal_respiratory_system0.97369688
94MP0003183_abnormal_peptide_metabolism0.96225053
95MP0005671_abnormal_response_to0.96154314
96MP0001915_intracranial_hemorrhage0.96073426
97MP0002080_prenatal_lethality0.95629984
98MP0002419_abnormal_innate_immunity0.95088749
99MP0005025_abnormal_response_to0.94899244
100MP0001873_stomach_inflammation0.94747021
101MP0005275_abnormal_skin_tensile0.94444042
102MP0000313_abnormal_cell_death0.93504169
103MP0004264_abnormal_extraembryonic_tissu0.92918512
104MP0003221_abnormal_cardiomyocyte_apopto0.92652716
105MP0005023_abnormal_wound_healing0.91332440
106MP0010630_abnormal_cardiac_muscle0.90348051
107MP0005387_immune_system_phenotype0.89809367
108MP0001790_abnormal_immune_system0.89809367
109MP0002998_abnormal_bone_remodeling0.89200219
110MP0001216_abnormal_epidermal_layer0.89108655
111MP0002084_abnormal_developmental_patter0.88102182
112MP0008004_abnormal_stomach_pH0.87623780
113MP0009931_abnormal_skin_appearance0.85751080
114MP0001845_abnormal_inflammatory_respons0.83391279
115MP0000477_abnormal_intestine_morphology0.82978867
116MP0003941_abnormal_skin_development0.82873635
117MP0009785_altered_susceptibility_to0.82328137
118MP0002095_abnormal_skin_pigmentation0.82301875
119MP0003448_altered_tumor_morphology0.81433557
120MP0003123_paternal_imprinting0.81399971
121MP0002148_abnormal_hypersensitivity_rea0.81051245
122MP0003866_abnormal_defecation0.80513040
123MP0005164_abnormal_response_to0.80496359
124MP0000767_abnormal_smooth_muscle0.79110152
125MP0002092_abnormal_eye_morphology0.79044161
126MP0002009_preneoplasia0.78995058
127MP0001533_abnormal_skeleton_physiology0.78088228
128MP0003795_abnormal_bone_structure0.77269549
129MP0000427_abnormal_hair_cycle0.76484105
130MP0005375_adipose_tissue_phenotype0.76359013
131MP0004883_abnormal_blood_vessel0.75915762
132MP0004782_abnormal_surfactant_physiolog0.75907063
133MP0000627_abnormal_mammary_gland0.75609938
134MP0003943_abnormal_hepatobiliary_system0.75329512
135MP0005384_cellular_phenotype0.75232690

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)3.53396063
2Thrombocytosis (HP:0001894)3.43186980
3Abnormality of the fingertips (HP:0001211)3.38542004
4Abnormality of cells of the erythroid lineage (HP:0012130)3.28343594
5Acute myeloid leukemia (HP:0004808)3.19425974
6Abnormal number of erythroid precursors (HP:0012131)3.16397118
7Abnormality of nail color (HP:0100643)3.11270910
8Papillary thyroid carcinoma (HP:0002895)3.06326215
9Ankyloglossia (HP:0010296)2.88016401
10Reticulocytopenia (HP:0001896)2.80926221
11IgM deficiency (HP:0002850)2.72542830
12Abnormality of macrophages (HP:0004311)2.67786389
13Recurrent viral infections (HP:0004429)2.58790849
14Prolonged bleeding time (HP:0003010)2.57831966
15Flat acetabular roof (HP:0003180)2.52801094
16Rectal prolapse (HP:0002035)2.50746680
17Aplastic anemia (HP:0001915)2.42428761
18Impaired platelet aggregation (HP:0003540)2.42344057
19Abnormal platelet function (HP:0011869)2.42344057
20Abnormality of oral frenula (HP:0000190)2.39784248
21Subacute progressive viral hepatitis (HP:0006572)2.39194770
22Prominent nose (HP:0000448)2.39131674
23Recurrent fungal infections (HP:0002841)2.38491813
24Colon cancer (HP:0003003)2.37876559
25Right ventricular cardiomyopathy (HP:0011663)2.34989336
26Cellulitis (HP:0100658)2.34192911
27Thick nail (HP:0001805)2.31378317
28Hematochezia (HP:0002573)2.30938496
29Overlapping toe (HP:0001845)2.30820910
30Gingivitis (HP:0000230)2.26930273
31Abnormality of the distal phalanx of the thumb (HP:0009617)2.24585166
32Myelodysplasia (HP:0002863)2.24559145
33Pili torti (HP:0003777)2.18134119
34Osteolytic defects of the hand bones (HP:0009699)2.17619943
35Osteolytic defects of the phalanges of the hand (HP:0009771)2.17619943
36Curly hair (HP:0002212)2.17604949
37Persistence of primary teeth (HP:0006335)2.15833728
38Spontaneous hematomas (HP:0007420)2.14142536
39Periodontitis (HP:0000704)2.14124200
40Pallor (HP:0000980)2.12704566
41Polycythemia (HP:0001901)2.12403740
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12370156
43Milia (HP:0001056)2.12065435
44Hyperacusis (HP:0010780)2.12057464
45Spinal cord lesions (HP:0100561)2.12001827
46Syringomyelia (HP:0003396)2.12001827
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.07850580
48Disproportionate tall stature (HP:0001519)2.07447310
49Autoimmune thrombocytopenia (HP:0001973)2.07003522
50Thoracolumbar scoliosis (HP:0002944)2.06171619
51Broad face (HP:0000283)2.05614790
52Abnormality of T cell physiology (HP:0011840)2.02083270
53Selective tooth agenesis (HP:0001592)2.01061725
54Eczematoid dermatitis (HP:0000976)1.99858153
55Volvulus (HP:0002580)1.99849496
56Pustule (HP:0200039)1.99772185
57Asymmetry of the thorax (HP:0001555)1.99477857
58Epistaxis (HP:0000421)1.97919940
59Abnormal delayed hypersensitivity skin test (HP:0002963)1.97890722
60Heterotopia (HP:0002282)1.96563520
61Abnormality of the salivary glands (HP:0010286)1.96286625
62Deviation of the thumb (HP:0009603)1.95893628
63Uterine leiomyosarcoma (HP:0002891)1.95503063
64Leiomyosarcoma (HP:0100243)1.95503063
65T lymphocytopenia (HP:0005403)1.95316730
66Abnormal platelet volume (HP:0011876)1.94121698
67Cutaneous melanoma (HP:0012056)1.91966452
68Blepharitis (HP:0000498)1.91816447
69Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90384150
70Distal lower limb amyotrophy (HP:0008944)1.90229742
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90113665
72Short 4th metacarpal (HP:0010044)1.90113665
73Micronodular cirrhosis (HP:0001413)1.89537045
74Increased density of long bones (HP:0006392)1.89378485
75Increased IgE level (HP:0003212)1.88287220
76Abnormality of T cells (HP:0002843)1.87696593
77Vertebral arch anomaly (HP:0008438)1.86803974
78Pelvic girdle muscle weakness (HP:0003749)1.85852557
79Chronic otitis media (HP:0000389)1.85702096
80Metaphyseal cupping (HP:0003021)1.85383388
81Breast aplasia (HP:0100783)1.85058906
82Recurrent bronchitis (HP:0002837)1.84964667
83Arterial thrombosis (HP:0004420)1.84505855
84Transitional cell carcinoma of the bladder (HP:0006740)1.84379259
85Increased connective tissue (HP:0009025)1.84164000
86Onycholysis (HP:0001806)1.84059852
87Abnormality of T cell number (HP:0011839)1.83172109
88Increased nuchal translucency (HP:0010880)1.82332037
89Anosmia (HP:0000458)1.81378233
90Bicuspid aortic valve (HP:0001647)1.81123995
91Myositis (HP:0100614)1.78757334
92Viral hepatitis (HP:0006562)1.78716831
93Thin bony cortex (HP:0002753)1.78348668
94Proximal placement of thumb (HP:0009623)1.78227642
95High pitched voice (HP:0001620)1.77673657
96Bladder neoplasm (HP:0009725)1.77643127
97Bladder carcinoma (HP:0002862)1.77643127
98Leukocytosis (HP:0001974)1.76624105
99Deep philtrum (HP:0002002)1.75691671
100Coarse hair (HP:0002208)1.74733913
10111 pairs of ribs (HP:0000878)1.74446510
102Dislocated radial head (HP:0003083)1.72927391
103Macrocytic anemia (HP:0001972)1.72421403
104Birth length less than 3rd percentile (HP:0003561)1.72411481
105Enlarged penis (HP:0000040)1.71316507
106Renal cell carcinoma (HP:0005584)1.70968668
107Protrusio acetabuli (HP:0003179)1.70799404
108Fatigue (HP:0012378)1.70673393
109Aortic aneurysm (HP:0004942)1.70551233
110Atresia of the external auditory canal (HP:0000413)1.70538389
111Long eyelashes (HP:0000527)1.70453269
112Malignant gastrointestinal tract tumors (HP:0006749)1.70434618
113Gastrointestinal carcinoma (HP:0002672)1.70434618
114Aplasia/Hypoplasia of the breasts (HP:0010311)1.70421071
115Mitral valve prolapse (HP:0001634)1.69527818
116Germ cell neoplasia (HP:0100728)1.69377649
117Recurrent abscess formation (HP:0002722)1.69288516
118Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69273191
119Segmental peripheral demyelination/remyelination (HP:0003481)1.68921658
120Abnormal foot bone ossification (HP:0010675)1.68891847
121Recurrent skin infections (HP:0001581)1.68784762
122Bilateral sensorineural hearing impairment (HP:0008619)1.68749707
123Ankle contracture (HP:0006466)1.68431811
124Septate vagina (HP:0001153)1.67886591
125Poikilocytosis (HP:0004447)1.67532223
126Recurrent bacterial skin infections (HP:0005406)1.67442468
127Sparse lateral eyebrow (HP:0005338)1.67427736
128Increased mean platelet volume (HP:0011877)1.67295400
129Urticaria (HP:0001025)1.67268285
130Cerebral aneurysm (HP:0004944)1.66457961
131Thyroid carcinoma (HP:0002890)1.66291643
132Lip pit (HP:0100267)1.66258748
133Macroorchidism (HP:0000053)1.65611410
134Cervical subluxation (HP:0003308)1.65517539
135Arterial tortuosity (HP:0005116)1.63643723
136Lymphoma (HP:0002665)1.62771587
137Abnormality of B cell number (HP:0010975)1.62596928
138B lymphocytopenia (HP:0010976)1.62596928
139Recurrent gram-negative bacterial infections (HP:0005420)1.62170244
140Broad palm (HP:0001169)1.62131033
141Osteomyelitis (HP:0002754)1.61504828
142Abnormality of the left ventricular outflow tract (HP:0011103)1.60048665
143Subaortic stenosis (HP:0001682)1.60048665
144Basal cell carcinoma (HP:0002671)1.59711997
145Abnormality of chromosome stability (HP:0003220)1.59158034
146Advanced eruption of teeth (HP:0006288)1.58965467
147Slow saccadic eye movements (HP:0000514)1.57672385
148Chest pain (HP:0100749)1.57628349
149Abnormality of the gastric mucosa (HP:0004295)1.57210303
150Skin tags (HP:0010609)1.57027532
151Bowel incontinence (HP:0002607)1.56839877
152Hypochromic anemia (HP:0001931)1.56786211
153Recurrent cutaneous fungal infections (HP:0011370)1.56758823
154Relative macrocephaly (HP:0004482)1.56687025
155Plantar hyperkeratosis (HP:0007556)1.56286116
156Ridged nail (HP:0001807)1.55907263
157Abnormal vertebral ossification (HP:0100569)1.55431125
158Abnormality of the radial head (HP:0003995)1.55339722
159Sandal gap (HP:0001852)1.54800867
160Dilatation of the ascending aorta (HP:0005111)1.54766395
161Reticulocytosis (HP:0001923)1.54764242
162Missing ribs (HP:0000921)1.52239127
163Long palpebral fissure (HP:0000637)1.50956256
164Abnormality of the thoracic spine (HP:0100711)1.50878670
165Atrophic scars (HP:0001075)1.50867740
166Patellar dislocation (HP:0002999)1.50548456
167Dysmetric saccades (HP:0000641)1.50093905
168Abnormal large intestine physiology (HP:0012700)1.49862636
169Abnormal blistering of the skin (HP:0008066)1.48270808
170Neonatal hypoglycemia (HP:0001998)1.47571552
171Capillary hemangiomas (HP:0005306)1.45771542

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.63096611
2PRPF4B3.23257428
3MAP3K102.82783392
4CDC72.69620103
5PKN22.59272824
6RIPK42.42005506
7MAP4K12.35871783
8NEK22.28105987
9RPS6KA42.12702597
10TRIB32.09812617
11KSR22.03205960
12PLK41.98455785
13SIK11.95262035
14CDK121.92442428
15SMG11.89467842
16MAP3K21.79879456
17STK101.77470314
18MKNK11.70821996
19NEK91.66641426
20TAOK31.59383049
21MAP3K131.57158557
22WEE11.53437036
23LATS11.53394482
24DYRK31.52528421
25YES11.50853313
26STK31.50316929
27PIM21.49675619
28RPS6KB21.47952577
29ACVR1B1.47135493
30MKNK21.46940335
31LRRK21.46836661
32CDK41.46052231
33BLK1.45744991
34CDK61.42967100
35ICK1.40878191
36ERBB31.38979492
37PIM11.37848020
38BRSK21.37389141
39CAMK1D1.36158999
40JAK31.35809371
41ZAP701.32557759
42TYK21.31765822
43KSR11.30680736
44CSK1.28834202
45LATS21.28696890
46EPHA21.27303430
47BTK1.25574360
48CAMK1G1.23559835
49MAPKAPK31.23344365
50PTK61.21909815
51EPHB11.18599068
52MAP3K11.17267273
53WNK11.14142525
54MST1R1.13961890
55PDGFRA1.13268882
56SRPK11.12378438
57NME21.08175986
58FLT31.06635540
59TTN1.05975550
60STK41.05158991
61MAP2K31.04727393
62TRPM71.03059943
63RET0.99450929
64SIK30.99224190
65SCYL20.99000416
66CDK90.98741530
67FGR0.98667241
68CHUK0.97336284
69IRAK30.97136119
70IRAK20.96137389
71TGFBR20.95153315
72TBK10.93892090
73AURKB0.93603897
74NLK0.93246217
75TAOK20.92258029
76STK240.91408743
77TEC0.90902681
78MARK20.90143864
79IKBKB0.89788068
80RIPK10.89529359
81CLK10.88394247
82PDGFRB0.87081540
83FGFR40.86580609
84MET0.85547734
85IRAK10.85459345
86PASK0.82154185
87MARK30.81936250
88MAP3K80.81445739
89TGFBR10.80875490
90ERN10.80664308
91RAF10.80100163
92FGFR30.79181763
93ATR0.78401897
94MAP3K90.77939392
95MAP3K60.77646531
96TXK0.77219155
97NUAK10.77138313
98BMPR20.76833690
99SGK30.76747172
100ALK0.75717286
101BMX0.73855169
102CDK70.73402836
103MAPKAPK20.71976806
104MAP3K30.70597889
105EIF2AK10.70118645
106MTOR0.69005835
107HCK0.68926864
108KIT0.68116363
109IRAK40.68059655
110TTK0.67930696
111CHEK10.65016257
112JAK20.64474657
113MATK0.64212459
114IKBKE0.63609822
115BRD40.62953608
116JAK10.62268021
117ITK0.61610065
118SYK0.61073524
119PAK40.61064997
120DMPK0.59829049
121HIPK20.59345784
122PTK20.59256700
123MAP3K70.58319993
124NEK60.56831722
125DYRK1B0.56780806
126MAP3K140.56189349
127TAOK10.53805164
128MELK0.52746646
129FRK0.52290779
130CSF1R0.52252264
131PLK10.52068709
132PAK20.52066504
133RPS6KL10.51708973
134RPS6KC10.51708973
135PDPK10.51276960
136MAP2K20.50993721
137GRK60.50854058
138PIK3CG0.49953204
139ATM0.48406632
140RPS6KA60.48200261
141VRK10.48151861
142CHEK20.47586309
143BRAF0.46685913
144MOS0.46429432
145CDC42BPA0.45246525
146LCK0.45175961
147RPS6KA50.44345496
148CDK20.44126566
149STK380.43925575

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.91550389
2Cell cycle_Homo sapiens_hsa041102.20390906
3Ribosome_Homo sapiens_hsa030102.08332842
4Chronic myeloid leukemia_Homo sapiens_hsa052202.00186439
5Renal cell carcinoma_Homo sapiens_hsa052111.95775786
6Mismatch repair_Homo sapiens_hsa034301.93209640
7Spliceosome_Homo sapiens_hsa030401.92225341
8RNA transport_Homo sapiens_hsa030131.89457303
9Base excision repair_Homo sapiens_hsa034101.71101894
10Homologous recombination_Homo sapiens_hsa034401.70138714
11p53 signaling pathway_Homo sapiens_hsa041151.66447388
12Herpes simplex infection_Homo sapiens_hsa051681.65539199
13Leishmaniasis_Homo sapiens_hsa051401.59388060
14mRNA surveillance pathway_Homo sapiens_hsa030151.52256905
15Small cell lung cancer_Homo sapiens_hsa052221.52046476
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48459326
17VEGF signaling pathway_Homo sapiens_hsa043701.47300711
18Non-homologous end-joining_Homo sapiens_hsa034501.44239033
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.44170332
20Acute myeloid leukemia_Homo sapiens_hsa052211.43382538
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.42436052
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.39664872
23Nucleotide excision repair_Homo sapiens_hsa034201.38624287
24Primary immunodeficiency_Homo sapiens_hsa053401.38582400
25ErbB signaling pathway_Homo sapiens_hsa040121.37515384
26Osteoclast differentiation_Homo sapiens_hsa043801.36990316
27Viral carcinogenesis_Homo sapiens_hsa052031.35561081
28B cell receptor signaling pathway_Homo sapiens_hsa046621.34850018
29Measles_Homo sapiens_hsa051621.34546261
30Hepatitis B_Homo sapiens_hsa051611.32824125
31Pancreatic cancer_Homo sapiens_hsa052121.32425302
32Apoptosis_Homo sapiens_hsa042101.32418265
33Toxoplasmosis_Homo sapiens_hsa051451.31658444
34Antigen processing and presentation_Homo sapiens_hsa046121.30880472
35Fanconi anemia pathway_Homo sapiens_hsa034601.26957405
36One carbon pool by folate_Homo sapiens_hsa006701.26863680
37RNA degradation_Homo sapiens_hsa030181.25439445
38MicroRNAs in cancer_Homo sapiens_hsa052061.24621502
39Epstein-Barr virus infection_Homo sapiens_hsa051691.24301203
40Hematopoietic cell lineage_Homo sapiens_hsa046401.21929360
41Other glycan degradation_Homo sapiens_hsa005111.16874578
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16494342
43Glioma_Homo sapiens_hsa052141.14942803
44Notch signaling pathway_Homo sapiens_hsa043301.13898934
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.11517150
46HTLV-I infection_Homo sapiens_hsa051661.11268593
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09452100
48Inositol phosphate metabolism_Homo sapiens_hsa005621.07998134
49Dorso-ventral axis formation_Homo sapiens_hsa043201.07971102
50RNA polymerase_Homo sapiens_hsa030201.07704720
51Insulin signaling pathway_Homo sapiens_hsa049101.03887271
52Thyroid cancer_Homo sapiens_hsa052161.03587525
53Caffeine metabolism_Homo sapiens_hsa002321.03053270
54Choline metabolism in cancer_Homo sapiens_hsa052311.02848102
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.02649696
56Platelet activation_Homo sapiens_hsa046111.02575302
57Basal transcription factors_Homo sapiens_hsa030221.01815633
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01321240
59Legionellosis_Homo sapiens_hsa051341.00655543
60TNF signaling pathway_Homo sapiens_hsa046681.00058700
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99594114
62Pyrimidine metabolism_Homo sapiens_hsa002400.98750960
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.98469649
64Viral myocarditis_Homo sapiens_hsa054160.97998489
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97003023
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96760233
67Malaria_Homo sapiens_hsa051440.94999620
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94616805
69Colorectal cancer_Homo sapiens_hsa052100.94545508
70Influenza A_Homo sapiens_hsa051640.91881683
71TGF-beta signaling pathway_Homo sapiens_hsa043500.90900391
72Shigellosis_Homo sapiens_hsa051310.90555036
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89735490
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.87980652
75Non-small cell lung cancer_Homo sapiens_hsa052230.87146763
76Chemokine signaling pathway_Homo sapiens_hsa040620.87069929
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87016068
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86487247
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85540266
80FoxO signaling pathway_Homo sapiens_hsa040680.85315314
81Prolactin signaling pathway_Homo sapiens_hsa049170.84333551
82GnRH signaling pathway_Homo sapiens_hsa049120.84323022
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84134051
84T cell receptor signaling pathway_Homo sapiens_hsa046600.83876104
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83685595
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.82877721
87Tuberculosis_Homo sapiens_hsa051520.81840104
88Salmonella infection_Homo sapiens_hsa051320.81737773
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81121468
90Prostate cancer_Homo sapiens_hsa052150.80842331
91Adherens junction_Homo sapiens_hsa045200.80377145
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.78818794
93Hepatitis C_Homo sapiens_hsa051600.77908521
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77529005
95Pentose phosphate pathway_Homo sapiens_hsa000300.75036295
96Estrogen signaling pathway_Homo sapiens_hsa049150.74812868
97Proteoglycans in cancer_Homo sapiens_hsa052050.73731160
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72997619
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70538298
100N-Glycan biosynthesis_Homo sapiens_hsa005100.69324805
101Pathways in cancer_Homo sapiens_hsa052000.68383184
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.68188432
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67971070
104Selenocompound metabolism_Homo sapiens_hsa004500.67807105
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67540679
106Endometrial cancer_Homo sapiens_hsa052130.67442103
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66581470
108Lysine degradation_Homo sapiens_hsa003100.66061463
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65830407
110Endocytosis_Homo sapiens_hsa041440.65814144
111Pertussis_Homo sapiens_hsa051330.63988313
112AMPK signaling pathway_Homo sapiens_hsa041520.63204251
113mTOR signaling pathway_Homo sapiens_hsa041500.62916143
114Type II diabetes mellitus_Homo sapiens_hsa049300.61442795
115Focal adhesion_Homo sapiens_hsa045100.61401254
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61199023
117ECM-receptor interaction_Homo sapiens_hsa045120.60582499
118Amoebiasis_Homo sapiens_hsa051460.59230020
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59191040
120Insulin resistance_Homo sapiens_hsa049310.57623374
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57342106
122Bladder cancer_Homo sapiens_hsa052190.56053616
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55659479
124Melanoma_Homo sapiens_hsa052180.54269737
125Systemic lupus erythematosus_Homo sapiens_hsa053220.54233510
126HIF-1 signaling pathway_Homo sapiens_hsa040660.53546379
127Galactose metabolism_Homo sapiens_hsa000520.52036061
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51013516
129Prion diseases_Homo sapiens_hsa050200.50585464
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50387994
131Rap1 signaling pathway_Homo sapiens_hsa040150.48554136
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47322518

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