

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of gene silencing by RNA (GO:0060966) | 5.36511416 |
| 2 | regulation of posttranscriptional gene silencing (GO:0060147) | 5.36511416 |
| 3 | regulation of gene silencing by miRNA (GO:0060964) | 5.36511416 |
| 4 | pre-miRNA processing (GO:0031054) | 5.22007940 |
| 5 | DNA unwinding involved in DNA replication (GO:0006268) | 4.57977643 |
| 6 | convergent extension (GO:0060026) | 4.49922171 |
| 7 | paraxial mesoderm development (GO:0048339) | 4.48897237 |
| 8 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 4.47655751 |
| 9 | nuclear pore organization (GO:0006999) | 4.43030785 |
| 10 | protein localization to kinetochore (GO:0034501) | 4.37855779 |
| 11 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.24008027 |
| 12 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.24008027 |
| 13 | nuclear pore complex assembly (GO:0051292) | 4.21525391 |
| 14 | heterochromatin organization (GO:0070828) | 4.21432536 |
| 15 | mitotic sister chromatid segregation (GO:0000070) | 4.05055218 |
| 16 | protein-DNA complex disassembly (GO:0032986) | 3.98387047 |
| 17 | nucleosome disassembly (GO:0006337) | 3.98387047 |
| 18 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.87574876 |
| 19 | establishment of apical/basal cell polarity (GO:0035089) | 3.86062446 |
| 20 | sister chromatid segregation (GO:0000819) | 3.82456612 |
| 21 | cell migration in hindbrain (GO:0021535) | 3.76950230 |
| 22 | histone H4-K12 acetylation (GO:0043983) | 3.75292597 |
| 23 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.72494253 |
| 24 | histone arginine methylation (GO:0034969) | 3.67810255 |
| 25 | regulation of translational fidelity (GO:0006450) | 3.67016166 |
| 26 | chromatin assembly (GO:0031497) | 3.61102031 |
| 27 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.60755690 |
| 28 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.60755690 |
| 29 | presynaptic membrane assembly (GO:0097105) | 3.59331335 |
| 30 | DNA duplex unwinding (GO:0032508) | 3.56878023 |
| 31 | mitotic nuclear envelope disassembly (GO:0007077) | 3.56542036 |
| 32 | DNA geometric change (GO:0032392) | 3.55337557 |
| 33 | establishment of integrated proviral latency (GO:0075713) | 3.54722153 |
| 34 | lateral sprouting from an epithelium (GO:0060601) | 3.53133808 |
| 35 | protein localization to chromosome, centromeric region (GO:0071459) | 3.50698298 |
| 36 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.49527253 |
| 37 | formation of translation preinitiation complex (GO:0001731) | 3.47355719 |
| 38 | regulation of sister chromatid cohesion (GO:0007063) | 3.47282130 |
| 39 | negative regulation of mRNA processing (GO:0050686) | 3.45856899 |
| 40 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.45596358 |
| 41 | negative regulation of histone methylation (GO:0031061) | 3.42209506 |
| 42 | regulation of hippo signaling (GO:0035330) | 3.41420966 |
| 43 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.39695271 |
| 44 | regulation of histone H3-K9 methylation (GO:0051570) | 3.35892111 |
| 45 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 3.34129169 |
| 46 | establishment of monopolar cell polarity (GO:0061162) | 3.34129169 |
| 47 | membrane disassembly (GO:0030397) | 3.33459881 |
| 48 | nuclear envelope disassembly (GO:0051081) | 3.33459881 |
| 49 | DNA replication initiation (GO:0006270) | 3.33404987 |
| 50 | presynaptic membrane organization (GO:0097090) | 3.32505353 |
| 51 | regulation of telomere maintenance via telomerase (GO:0032210) | 3.30416046 |
| 52 | peptidyl-arginine N-methylation (GO:0035246) | 3.29993658 |
| 53 | peptidyl-arginine methylation (GO:0018216) | 3.29993658 |
| 54 | lung-associated mesenchyme development (GO:0060484) | 3.29908226 |
| 55 | positive regulation of chromosome segregation (GO:0051984) | 3.27517983 |
| 56 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 3.26463919 |
| 57 | negative regulation of RNA splicing (GO:0033119) | 3.25657983 |
| 58 | establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197) | 3.25610480 |
| 59 | regulation of helicase activity (GO:0051095) | 3.25486503 |
| 60 | regulation of cell fate specification (GO:0042659) | 3.24695852 |
| 61 | outer ear morphogenesis (GO:0042473) | 3.24582143 |
| 62 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 3.23906674 |
| 63 | regulation of RNA export from nucleus (GO:0046831) | 3.19575668 |
| 64 | regulation of gene silencing (GO:0060968) | 3.19248102 |
| 65 | dosage compensation (GO:0007549) | 3.16863695 |
| 66 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.15560672 |
| 67 | histone H4-K5 acetylation (GO:0043981) | 3.15537703 |
| 68 | histone H4-K8 acetylation (GO:0043982) | 3.15537703 |
| 69 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 3.13309770 |
| 70 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.11846523 |
| 71 | regulation of establishment of planar polarity (GO:0090175) | 3.09227475 |
| 72 | mitotic metaphase plate congression (GO:0007080) | 3.09145612 |
| 73 | trophectodermal cell differentiation (GO:0001829) | 3.09094869 |
| 74 | polarized epithelial cell differentiation (GO:0030859) | 3.08243398 |
| 75 | pore complex assembly (GO:0046931) | 3.06014603 |
| 76 | postsynaptic membrane organization (GO:0001941) | 3.05217996 |
| 77 | notochord development (GO:0030903) | 3.03650305 |
| 78 | L-serine metabolic process (GO:0006563) | 3.02337818 |
| 79 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.02131116 |
| 80 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.02131116 |
| 81 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.02131116 |
| 82 | cranial nerve development (GO:0021545) | 3.01726153 |
| 83 | negative regulation of mRNA metabolic process (GO:1903312) | 3.01378903 |
| 84 | mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337) | 3.01250585 |
| 85 | RNA stabilization (GO:0043489) | 3.00417017 |
| 86 | mRNA stabilization (GO:0048255) | 3.00417017 |
| 87 | anterior/posterior axis specification, embryo (GO:0008595) | 2.99479831 |
| 88 | mitotic chromosome condensation (GO:0007076) | 2.99057623 |
| 89 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.95593224 |
| 90 | spinal cord development (GO:0021510) | 2.94959256 |
| 91 | intracellular estrogen receptor signaling pathway (GO:0030520) | 2.94892390 |
| 92 | DNA strand elongation (GO:0022616) | 2.93201274 |
| 93 | neuronal stem cell maintenance (GO:0097150) | 2.92087787 |
| 94 | negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147) | 2.91896782 |
| 95 | non-canonical Wnt signaling pathway (GO:0035567) | 2.91208634 |
| 96 | regulation of DNA damage checkpoint (GO:2000001) | 2.89228607 |
| 97 | somatic stem cell division (GO:0048103) | 2.89117899 |
| 98 | mesenchymal to epithelial transition (GO:0060231) | 2.88003284 |
| 99 | mRNA transport (GO:0051028) | 2.86990310 |
| 100 | regulation of stem cell maintenance (GO:2000036) | 2.86236120 |
| 101 | nodal signaling pathway (GO:0038092) | 2.85666965 |
| 102 | establishment or maintenance of apical/basal cell polarity (GO:0035088) | 2.85501424 |
| 103 | establishment or maintenance of bipolar cell polarity (GO:0061245) | 2.85501424 |
| 104 | negative regulation of chromosome segregation (GO:0051985) | 2.84874595 |
| 105 | positive regulation of G2/M transition of mitotic cell cycle (GO:0010971) | 2.84726875 |
| 106 | positive regulation of cell cycle G2/M phase transition (GO:1902751) | 2.84726875 |
| 107 | histone H2A monoubiquitination (GO:0035518) | 2.84492294 |
| 108 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.83972723 |
| 109 | IMP biosynthetic process (GO:0006188) | 2.82982721 |
| 110 | replication fork processing (GO:0031297) | 2.81280539 |
| 111 | DNA replication checkpoint (GO:0000076) | 2.80245391 |
| 112 | mRNA splicing, via spliceosome (GO:0000398) | 2.79324641 |
| 113 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.79324641 |
| 114 | ribosome biogenesis (GO:0042254) | 2.79170752 |
| 115 | generation of neurons (GO:0048699) | 2.78660285 |
| 116 | RNA splicing, via transesterification reactions (GO:0000375) | 2.78636492 |
| 117 | termination of RNA polymerase II transcription (GO:0006369) | 2.76738002 |
| 118 | regulation of chromosome segregation (GO:0051983) | 2.76686523 |
| 119 | DNA conformation change (GO:0071103) | 2.76309722 |
| 120 | regulation of double-strand break repair (GO:2000779) | 2.75215047 |
| 121 | regulation of intracellular estrogen receptor signaling pathway (GO:0033146) | 2.74250332 |
| 122 | chromatin assembly or disassembly (GO:0006333) | 2.73763562 |
| 123 | protein complex localization (GO:0031503) | 2.73465762 |
| 124 | apical protein localization (GO:0045176) | 2.72514045 |
| 125 | transcription from mitochondrial promoter (GO:0006390) | 2.72276381 |
| 126 | dorsal/ventral axis specification (GO:0009950) | 2.72174415 |
| 127 | axon extension involved in axon guidance (GO:0048846) | 2.71492310 |
| 128 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.71492310 |
| 129 | ATP-dependent chromatin remodeling (GO:0043044) | 2.71280558 |
| 130 | determination of adult lifespan (GO:0008340) | 2.71110125 |
| 131 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla | 2.69988315 |
| 132 | regulation of SMAD protein import into nucleus (GO:0060390) | 2.69146243 |
| 133 | metaphase plate congression (GO:0051310) | 2.68667589 |
| 134 | kinetochore organization (GO:0051383) | 2.68584929 |
| 135 | nucleobase biosynthetic process (GO:0046112) | 2.68450448 |
| 136 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.68239840 |
| 137 | negative regulation of gene silencing (GO:0060969) | 2.67646541 |
| 138 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.66926047 |
| 139 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.66926047 |
| 140 | regulation of translation, ncRNA-mediated (GO:0045974) | 2.66926047 |
| 141 | nuclear envelope organization (GO:0006998) | 2.66314605 |
| 142 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.65776597 |
| 143 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.63585732 |
| 144 | enteric nervous system development (GO:0048484) | 2.60379197 |
| 145 | neural tube development (GO:0021915) | 2.58544539 |
| 146 | axonal fasciculation (GO:0007413) | 2.56929586 |
| 147 | cell surface receptor signaling pathway involved in heart development (GO:0061311) | 2.55783344 |
| 148 | post-anal tail morphogenesis (GO:0036342) | 2.55621078 |
| 149 | body morphogenesis (GO:0010171) | 2.54155353 |
| 150 | regulation of catenin import into nucleus (GO:0035412) | 2.53125256 |
| 151 | positive regulation of catenin import into nucleus (GO:0035413) | 2.52164160 |
| 152 | neuron recognition (GO:0008038) | 2.51754622 |
| 153 | cochlea morphogenesis (GO:0090103) | 2.50599076 |
| 154 | establishment of planar polarity (GO:0001736) | 2.50326497 |
| 155 | establishment of tissue polarity (GO:0007164) | 2.50326497 |
| 156 | regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095) | 2.49445231 |
| 157 | camera-type eye morphogenesis (GO:0048593) | 2.48591206 |
| 158 | digestive tract morphogenesis (GO:0048546) | 2.48388989 |
| 159 | neural tube closure (GO:0001843) | 2.46788896 |
| 160 | midbrain development (GO:0030901) | 2.46485005 |
| 161 | establishment of viral latency (GO:0019043) | 2.46177948 |
| 162 | nucleobase catabolic process (GO:0046113) | 2.46109833 |
| 163 | DNA topological change (GO:0006265) | 2.46027509 |
| 164 | tube closure (GO:0060606) | 2.43877179 |
| 165 | negative regulation of cell fate specification (GO:0009996) | 2.41122227 |
| 166 | regulation of mRNA stability (GO:0043488) | 2.37310812 |
| 167 | neuron cell-cell adhesion (GO:0007158) | 2.35956165 |
| 168 | regulation of non-canonical Wnt signaling pathway (GO:2000050) | 2.32848084 |
| 169 | viral transcription (GO:0019083) | 2.32549519 |
| 170 | embryonic body morphogenesis (GO:0010172) | 2.31832523 |
| 171 | branching involved in salivary gland morphogenesis (GO:0060445) | 2.30456109 |
| 172 | ectodermal placode formation (GO:0060788) | 2.30377269 |
| 173 | positive regulation of gene expression, epigenetic (GO:0045815) | 2.30297450 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.11964386 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.49336277 |
| 3 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 3.63270115 |
| 4 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 3.63270115 |
| 5 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 3.63270115 |
| 6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.52010664 |
| 7 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 3.40876440 |
| 8 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 3.21925136 |
| 9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.17451204 |
| 10 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.14338874 |
| 11 | * SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 3.09113109 |
| 12 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.93956055 |
| 13 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.91757121 |
| 14 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.74847620 |
| 15 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 2.67063398 |
| 16 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 2.57445876 |
| 17 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.55630540 |
| 18 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.47621191 |
| 19 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.38466364 |
| 20 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 2.34621398 |
| 21 | * NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 2.25990462 |
| 22 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 2.23514330 |
| 23 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 2.21987775 |
| 24 | * SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 2.21664435 |
| 25 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 2.17752165 |
| 26 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 2.14777815 |
| 27 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.14735931 |
| 28 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.14478120 |
| 29 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 2.10742282 |
| 30 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 2.09392687 |
| 31 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 2.08814791 |
| 32 | * TCF3_18692474_ChIP-Seq_MESCs_Mouse | 2.06483440 |
| 33 | MYC_22102868_ChIP-Seq_BL_Human | 2.05244398 |
| 34 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 2.03966342 |
| 35 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.02633947 |
| 36 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 2.02356989 |
| 37 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.97050489 |
| 38 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.95239150 |
| 39 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.90228081 |
| 40 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.90142789 |
| 41 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.85127897 |
| 42 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.84769918 |
| 43 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.83048533 |
| 44 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.81406836 |
| 45 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.80770090 |
| 46 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.79645052 |
| 47 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.72946545 |
| 48 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.72607186 |
| 49 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.72516452 |
| 50 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.71600283 |
| 51 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.70561892 |
| 52 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 1.65175302 |
| 53 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.65098701 |
| 54 | * POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.63591113 |
| 55 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.63481176 |
| 56 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.59578916 |
| 57 | * EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.59292103 |
| 58 | * NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.58874865 |
| 59 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.57414409 |
| 60 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.57134905 |
| 61 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.56632802 |
| 62 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.54182954 |
| 63 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.51048854 |
| 64 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.48103344 |
| 65 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.46807121 |
| 66 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.46553636 |
| 67 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.45914897 |
| 68 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.45668607 |
| 69 | * NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.45199633 |
| 70 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.43320919 |
| 71 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.43320919 |
| 72 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.40547480 |
| 73 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.40115760 |
| 74 | * SOX2_18692474_ChIP-Seq_MESCs_Mouse | 1.39710793 |
| 75 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.37906731 |
| 76 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.37591803 |
| 77 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.36794606 |
| 78 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.36711800 |
| 79 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.35563335 |
| 80 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.34156898 |
| 81 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.32994558 |
| 82 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.32034509 |
| 83 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.31790315 |
| 84 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.31669493 |
| 85 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.31548017 |
| 86 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.31218379 |
| 87 | TCF3_18347094_ChIP-ChIP_MESCs_Mouse | 1.30406358 |
| 88 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.30267323 |
| 89 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.28034480 |
| 90 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.27974975 |
| 91 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.27284515 |
| 92 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.27136993 |
| 93 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.27125542 |
| 94 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.26063631 |
| 95 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.25868766 |
| 96 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.25408115 |
| 97 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.25195156 |
| 98 | * POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 1.25053046 |
| 99 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.24939695 |
| 100 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.24415872 |
| 101 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.22193315 |
| 102 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.21431283 |
| 103 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.19760213 |
| 104 | * NANOG_18692474_ChIP-Seq_MESCs_Mouse | 1.18711031 |
| 105 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.17697904 |
| 106 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.16865548 |
| 107 | NANOG_18692474_ChIP-Seq_MEFs_Mouse | 1.15963413 |
| 108 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.14072991 |
| 109 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.13896054 |
| 110 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 1.12319779 |
| 111 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.12199096 |
| 112 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.11925282 |
| 113 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.11321276 |
| 114 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.09546523 |
| 115 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.09346187 |
| 116 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.08476157 |
| 117 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.07787021 |
| 118 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.06904699 |
| 119 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.05658216 |
| 120 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.04415889 |
| 121 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.04262577 |
| 122 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.03377886 |
| 123 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.03225337 |
| 124 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.03120334 |
| 125 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.02509873 |
| 126 | PRDM14_21183938_ChIP-Seq_MESCs_Mouse | 1.01900479 |
| 127 | SOX3_22085726_ChIP-Seq_NPCs_Mouse | 1.01291411 |
| 128 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.01179017 |
| 129 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 0.99152489 |
| 130 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.95806709 |
| 131 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.95337226 |
| 132 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.91999869 |
| 133 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.91865880 |
| 134 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.91837454 |
| 135 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.90905691 |
| 136 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 0.90460457 |
| 137 | * KDM2B_26808549_Chip-Seq_DND41_Human | 0.90369069 |
| 138 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.90318592 |
| 139 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.87886832 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 3.53884804 |
| 2 | MP0002653_abnormal_ependyma_morphology | 3.36223391 |
| 3 | MP0010030_abnormal_orbit_morphology | 3.21714987 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.19471240 |
| 5 | MP0003111_abnormal_nucleus_morphology | 3.13743926 |
| 6 | MP0010094_abnormal_chromosome_stability | 3.02259767 |
| 7 | MP0000566_synostosis | 2.80834339 |
| 8 | MP0003890_abnormal_embryonic-extraembry | 2.73040419 |
| 9 | MP0003077_abnormal_cell_cycle | 2.72352632 |
| 10 | MP0003693_abnormal_embryo_hatching | 2.59755969 |
| 11 | MP0003123_paternal_imprinting | 2.40700664 |
| 12 | MP0000778_abnormal_nervous_system | 2.36524071 |
| 13 | MP0006292_abnormal_olfactory_placode | 2.31678505 |
| 14 | MP0003119_abnormal_digestive_system | 2.21849949 |
| 15 | MP0002084_abnormal_developmental_patter | 2.21788309 |
| 16 | MP0001730_embryonic_growth_arrest | 2.18852441 |
| 17 | MP0010352_gastrointestinal_tract_polyps | 2.15915093 |
| 18 | MP0002085_abnormal_embryonic_tissue | 2.14216817 |
| 19 | MP0001293_anophthalmia | 2.12038417 |
| 20 | MP0001672_abnormal_embryogenesis/_devel | 2.06988242 |
| 21 | MP0005380_embryogenesis_phenotype | 2.06988242 |
| 22 | MP0000350_abnormal_cell_proliferation | 2.04807558 |
| 23 | MP0004133_heterotaxia | 2.02356612 |
| 24 | MP0005076_abnormal_cell_differentiation | 2.01745724 |
| 25 | MP0004197_abnormal_fetal_growth/weight/ | 1.99985507 |
| 26 | MP0008932_abnormal_embryonic_tissue | 1.98714586 |
| 27 | MP0000537_abnormal_urethra_morphology | 1.97816744 |
| 28 | MP0003121_genomic_imprinting | 1.95600538 |
| 29 | MP0003705_abnormal_hypodermis_morpholog | 1.89792464 |
| 30 | MP0003283_abnormal_digestive_organ | 1.88990565 |
| 31 | MP0001697_abnormal_embryo_size | 1.86887923 |
| 32 | MP0004858_abnormal_nervous_system | 1.86410846 |
| 33 | MP0008058_abnormal_DNA_repair | 1.85863290 |
| 34 | MP0004859_abnormal_synaptic_plasticity | 1.85326433 |
| 35 | MP0003984_embryonic_growth_retardation | 1.83228148 |
| 36 | MP0002088_abnormal_embryonic_growth/wei | 1.81217630 |
| 37 | MP0002086_abnormal_extraembryonic_tissu | 1.74253433 |
| 38 | MP0001299_abnormal_eye_distance/ | 1.68328501 |
| 39 | MP0005377_hearing/vestibular/ear_phenot | 1.66072085 |
| 40 | MP0003878_abnormal_ear_physiology | 1.66072085 |
| 41 | MP0008007_abnormal_cellular_replicative | 1.60910341 |
| 42 | MP0003567_abnormal_fetal_cardiomyocyte | 1.54378803 |
| 43 | MP0002080_prenatal_lethality | 1.52930032 |
| 44 | MP0002249_abnormal_larynx_morphology | 1.51617838 |
| 45 | MP0009053_abnormal_anal_canal | 1.51090184 |
| 46 | MP0008877_abnormal_DNA_methylation | 1.49324106 |
| 47 | MP0004270_analgesia | 1.48988141 |
| 48 | MP0001849_ear_inflammation | 1.45232314 |
| 49 | MP0009379_abnormal_foot_pigmentation | 1.40376993 |
| 50 | MP0003937_abnormal_limbs/digits/tail_de | 1.39635588 |
| 51 | MP0004233_abnormal_muscle_weight | 1.39070159 |
| 52 | MP0000955_abnormal_spinal_cord | 1.39011166 |
| 53 | MP0010307_abnormal_tumor_latency | 1.38778525 |
| 54 | MP0003861_abnormal_nervous_system | 1.38037793 |
| 55 | MP0000049_abnormal_middle_ear | 1.34092071 |
| 56 | MP0000428_abnormal_craniofacial_morphol | 1.33615944 |
| 57 | MP0002092_abnormal_eye_morphology | 1.32224262 |
| 58 | MP0003935_abnormal_craniofacial_develop | 1.30884112 |
| 59 | MP0002111_abnormal_tail_morphology | 1.30072455 |
| 60 | MP0009278_abnormal_bone_marrow | 1.29094708 |
| 61 | MP0002697_abnormal_eye_size | 1.29022936 |
| 62 | MP0000631_abnormal_neuroendocrine_gland | 1.26492031 |
| 63 | MP0002152_abnormal_brain_morphology | 1.26065785 |
| 64 | MP0003755_abnormal_palate_morphology | 1.25731651 |
| 65 | MP0005394_taste/olfaction_phenotype | 1.24756146 |
| 66 | MP0005499_abnormal_olfactory_system | 1.24756146 |
| 67 | MP0002822_catalepsy | 1.23631351 |
| 68 | MP0002932_abnormal_joint_morphology | 1.22938772 |
| 69 | MP0002254_reproductive_system_inflammat | 1.21556371 |
| 70 | MP0002184_abnormal_innervation | 1.20993443 |
| 71 | MP0000432_abnormal_head_morphology | 1.20315821 |
| 72 | MP0001286_abnormal_eye_development | 1.20291256 |
| 73 | MP0003122_maternal_imprinting | 1.19834704 |
| 74 | MP0001346_abnormal_lacrimal_gland | 1.19297687 |
| 75 | MP0003315_abnormal_perineum_morphology | 1.18331039 |
| 76 | MP0000579_abnormal_nail_morphology | 1.16524592 |
| 77 | MP0005623_abnormal_meninges_morphology | 1.16451300 |
| 78 | MP0008789_abnormal_olfactory_epithelium | 1.14295689 |
| 79 | MP0006072_abnormal_retinal_apoptosis | 1.13582020 |
| 80 | MP0003786_premature_aging | 1.12935468 |
| 81 | MP0004264_abnormal_extraembryonic_tissu | 1.10619480 |
| 82 | MP0002089_abnormal_postnatal_growth/wei | 1.10444750 |
| 83 | MP0009703_decreased_birth_body | 1.10259049 |
| 84 | MP0005423_abnormal_somatic_nervous | 1.10112590 |
| 85 | MP0003941_abnormal_skin_development | 1.07800896 |
| 86 | MP0002116_abnormal_craniofacial_bone | 1.07769913 |
| 87 | MP0002114_abnormal_axial_skeleton | 1.05089102 |
| 88 | MP0001984_abnormal_olfaction | 1.04120416 |
| 89 | MP0004811_abnormal_neuron_physiology | 1.02539932 |
| 90 | MP0000313_abnormal_cell_death | 1.01145846 |
| 91 | MP0003385_abnormal_body_wall | 1.01133147 |
| 92 | MP0006276_abnormal_autonomic_nervous | 0.99573329 |
| 93 | MP0001529_abnormal_vocalization | 0.98016450 |
| 94 | MP0003938_abnormal_ear_development | 0.97676032 |
| 95 | MP0002925_abnormal_cardiovascular_devel | 0.97654200 |
| 96 | MP0009672_abnormal_birth_weight | 0.97004961 |
| 97 | MP0002282_abnormal_trachea_morphology | 0.96804937 |
| 98 | MP0002882_abnormal_neuron_morphology | 0.95287359 |
| 99 | MP0002751_abnormal_autonomic_nervous | 0.94733735 |
| 100 | MP0002233_abnormal_nose_morphology | 0.94637934 |
| 101 | MP0003942_abnormal_urinary_system | 0.93970617 |
| 102 | MP0000490_abnormal_crypts_of | 0.93133629 |
| 103 | MP0003115_abnormal_respiratory_system | 0.92743983 |
| 104 | MP0000733_abnormal_muscle_development | 0.92431952 |
| 105 | MP0003880_abnormal_central_pattern | 0.91362365 |
| 106 | MP0005391_vision/eye_phenotype | 0.88386254 |
| 107 | MP0003635_abnormal_synaptic_transmissio | 0.88100000 |
| 108 | MP0002752_abnormal_somatic_nervous | 0.87888335 |
| 109 | MP0003787_abnormal_imprinting | 0.87496520 |
| 110 | MP0002210_abnormal_sex_determination | 0.87378996 |
| 111 | MP0003136_yellow_coat_color | 0.87169490 |
| 112 | MP0001145_abnormal_male_reproductive | 0.86845134 |
| 113 | MP0000762_abnormal_tongue_morphology | 0.86121301 |
| 114 | MP0001188_hyperpigmentation | 0.86109493 |
| 115 | MP0009250_abnormal_appendicular_skeleto | 0.85498708 |
| 116 | MP0002638_abnormal_pupillary_reflex | 0.84985520 |
| 117 | MP0002938_white_spotting | 0.84751281 |
| 118 | MP0002081_perinatal_lethality | 0.83178150 |
| 119 | MP0000534_abnormal_ureter_morphology | 0.81853071 |
| 120 | MP0002127_abnormal_cardiovascular_syste | 0.80907476 |
| 121 | MP0001915_intracranial_hemorrhage | 0.79570618 |
| 122 | MP0005367_renal/urinary_system_phenotyp | 0.79289990 |
| 123 | MP0000516_abnormal_urinary_system | 0.79289990 |
| 124 | MP0000678_abnormal_parathyroid_gland | 0.79250114 |
| 125 | MP0008770_decreased_survivor_rate | 0.77331692 |
| 126 | MP0005187_abnormal_penis_morphology | 0.74450483 |
| 127 | MP0004185_abnormal_adipocyte_glucose | 0.74343613 |
| 128 | MP0005257_abnormal_intraocular_pressure | 0.72948432 |
| 129 | MP0001348_abnormal_lacrimal_gland | 0.72483844 |
| 130 | MP0005248_abnormal_Harderian_gland | 0.72011996 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ependymoma (HP:0002888) | 4.71519593 |
| 2 | Rib fusion (HP:0000902) | 4.21448956 |
| 3 | Septo-optic dysplasia (HP:0100842) | 3.87939192 |
| 4 | Abnormality of the astrocytes (HP:0100707) | 3.80229029 |
| 5 | Astrocytoma (HP:0009592) | 3.80229029 |
| 6 | Medulloblastoma (HP:0002885) | 3.51793266 |
| 7 | Neoplasm of the oral cavity (HP:0100649) | 3.21405015 |
| 8 | Abnormality of the labia minora (HP:0012880) | 3.17054287 |
| 9 | Selective tooth agenesis (HP:0001592) | 3.14945034 |
| 10 | Neoplasm of striated muscle (HP:0009728) | 3.09432149 |
| 11 | Glioma (HP:0009733) | 3.06709149 |
| 12 | Abnormal number of incisors (HP:0011064) | 3.03587444 |
| 13 | Turricephaly (HP:0000262) | 3.02832141 |
| 14 | Rhabdomyosarcoma (HP:0002859) | 2.95231017 |
| 15 | Renal duplication (HP:0000075) | 2.91035098 |
| 16 | Partial duplication of thumb phalanx (HP:0009944) | 2.90483684 |
| 17 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.89964728 |
| 18 | Vitreoretinal degeneration (HP:0000655) | 2.87762590 |
| 19 | Short humerus (HP:0005792) | 2.83309504 |
| 20 | Cortical dysplasia (HP:0002539) | 2.75028796 |
| 21 | Absent radius (HP:0003974) | 2.74662307 |
| 22 | Partial duplication of the phalanx of hand (HP:0009999) | 2.74616137 |
| 23 | Supernumerary spleens (HP:0009799) | 2.72852347 |
| 24 | Abnormality of abdominal situs (HP:0011620) | 2.71443911 |
| 25 | Abdominal situs inversus (HP:0003363) | 2.71443911 |
| 26 | Choanal stenosis (HP:0000452) | 2.69027870 |
| 27 | Abnormality of the lower motor neuron (HP:0002366) | 2.67934704 |
| 28 | Short 4th metacarpal (HP:0010044) | 2.65540981 |
| 29 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.65540981 |
| 30 | Trigonocephaly (HP:0000243) | 2.63350524 |
| 31 | Aplasia involving forearm bones (HP:0009822) | 2.61882310 |
| 32 | Absent forearm bone (HP:0003953) | 2.61882310 |
| 33 | Rectal fistula (HP:0100590) | 2.60295786 |
| 34 | Rectovaginal fistula (HP:0000143) | 2.60295786 |
| 35 | Supernumerary ribs (HP:0005815) | 2.59872653 |
| 36 | Coronal craniosynostosis (HP:0004440) | 2.58368222 |
| 37 | Patellar aplasia (HP:0006443) | 2.57962104 |
| 38 | Maternal diabetes (HP:0009800) | 2.56607194 |
| 39 | Shawl scrotum (HP:0000049) | 2.55338299 |
| 40 | Esophageal atresia (HP:0002032) | 2.55036536 |
| 41 | Increased nuchal translucency (HP:0010880) | 2.54601151 |
| 42 | Colon cancer (HP:0003003) | 2.54251714 |
| 43 | Facial hemangioma (HP:0000329) | 2.52137858 |
| 44 | High anterior hairline (HP:0009890) | 2.49735018 |
| 45 | Missing ribs (HP:0000921) | 2.49417703 |
| 46 | Cutaneous syndactyly (HP:0012725) | 2.46668632 |
| 47 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.46058406 |
| 48 | Pseudobulbar signs (HP:0002200) | 2.45762573 |
| 49 | Supernumerary bones of the axial skeleton (HP:0009144) | 2.44201183 |
| 50 | Intestinal fistula (HP:0100819) | 2.43357296 |
| 51 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.41156531 |
| 52 | Vertebral fusion (HP:0002948) | 2.41100758 |
| 53 | Bilateral microphthalmos (HP:0007633) | 2.38549729 |
| 54 | Hemivertebrae (HP:0002937) | 2.38108841 |
| 55 | Abnormality of the aortic arch (HP:0012303) | 2.38101927 |
| 56 | Cutaneous finger syndactyly (HP:0010554) | 2.36226590 |
| 57 | Absent septum pellucidum (HP:0001331) | 2.33070287 |
| 58 | Volvulus (HP:0002580) | 2.32586606 |
| 59 | Chromsome breakage (HP:0040012) | 2.32348904 |
| 60 | Proximal placement of thumb (HP:0009623) | 2.31419297 |
| 61 | Abnormality of the septum pellucidum (HP:0007375) | 2.29945707 |
| 62 | Broad phalanges of the hand (HP:0009768) | 2.29599361 |
| 63 | Aqueductal stenosis (HP:0002410) | 2.28211451 |
| 64 | Broad finger (HP:0001500) | 2.25422859 |
| 65 | Shallow orbits (HP:0000586) | 2.23865158 |
| 66 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.21728734 |
| 67 | Deviation of the thumb (HP:0009603) | 2.20063138 |
| 68 | Anophthalmia (HP:0000528) | 2.18821881 |
| 69 | Reticulocytopenia (HP:0001896) | 2.18778811 |
| 70 | Bronchomalacia (HP:0002780) | 2.17425680 |
| 71 | Duplication of thumb phalanx (HP:0009942) | 2.16518429 |
| 72 | Myelomeningocele (HP:0002475) | 2.12430804 |
| 73 | Vaginal fistula (HP:0004320) | 2.11301189 |
| 74 | Intestinal atresia (HP:0011100) | 2.10096023 |
| 75 | Arnold-Chiari malformation (HP:0002308) | 2.09405344 |
| 76 | Broad long bones (HP:0005622) | 2.09258753 |
| 77 | Abnormality of the 4th metacarpal (HP:0010012) | 2.08717659 |
| 78 | Hyperacusis (HP:0010780) | 2.07778504 |
| 79 | Abnormality of the ileum (HP:0001549) | 2.07607998 |
| 80 | Basal cell carcinoma (HP:0002671) | 2.07430530 |
| 81 | Broad alveolar ridges (HP:0000187) | 2.07251461 |
| 82 | Broad phalanx (HP:0006009) | 2.06047576 |
| 83 | Impulsivity (HP:0100710) | 2.05875168 |
| 84 | Preaxial foot polydactyly (HP:0001841) | 2.05413086 |
| 85 | Atresia of the external auditory canal (HP:0000413) | 2.05224990 |
| 86 | Spastic diplegia (HP:0001264) | 2.04045195 |
| 87 | Abnormality of the diencephalon (HP:0010662) | 2.03679047 |
| 88 | Short phalanx of the thumb (HP:0009660) | 2.03012519 |
| 89 | Gastrointestinal atresia (HP:0002589) | 2.02990403 |
| 90 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.02641579 |
| 91 | Aplasia of the phalanges of the hand (HP:0009802) | 2.02641579 |
| 92 | Aplasia involving bones of the extremities (HP:0009825) | 2.02641579 |
| 93 | Breast hypoplasia (HP:0003187) | 2.00972699 |
| 94 | Renovascular hypertension (HP:0100817) | 2.00719164 |
| 95 | Omphalocele (HP:0001539) | 2.00707961 |
| 96 | Elfin facies (HP:0004428) | 1.99590620 |
| 97 | Ulnar bowing (HP:0003031) | 1.97554026 |
| 98 | Abnormality of the salivary glands (HP:0010286) | 1.97342583 |
| 99 | Broad thumb (HP:0011304) | 1.95930463 |
| 100 | Optic nerve hypoplasia (HP:0000609) | 1.95233572 |
| 101 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.94924605 |
| 102 | Gastrointestinal carcinoma (HP:0002672) | 1.94088668 |
| 103 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.94088668 |
| 104 | Skin tags (HP:0010609) | 1.93792659 |
| 105 | Large earlobe (HP:0009748) | 1.93445722 |
| 106 | Meckel diverticulum (HP:0002245) | 1.92730904 |
| 107 | Midline defect of the nose (HP:0004122) | 1.92130322 |
| 108 | Orthostatic hypotension (HP:0001278) | 1.91546433 |
| 109 | Broad metatarsal (HP:0001783) | 1.91141283 |
| 110 | Short 5th finger (HP:0009237) | 1.90130854 |
| 111 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.90077559 |
| 112 | Renal hypoplasia (HP:0000089) | 1.89376663 |
| 113 | Spina bifida occulta (HP:0003298) | 1.89174648 |
| 114 | Tracheoesophageal fistula (HP:0002575) | 1.87040053 |
| 115 | Partial agenesis of the corpus callosum (HP:0001338) | 1.86443759 |
| 116 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.85930871 |
| 117 | Absent thumb (HP:0009777) | 1.85592613 |
| 118 | Preauricular skin tag (HP:0000384) | 1.85031133 |
| 119 | Obsessive-compulsive behavior (HP:0000722) | 1.84920202 |
| 120 | Insomnia (HP:0100785) | 1.83929930 |
| 121 | Oligodactyly (HP:0012165) | 1.82406473 |
| 122 | Agnosia (HP:0010524) | 1.81602522 |
| 123 | Heterotopia (HP:0002282) | 1.80346231 |
| 124 | Thin ribs (HP:0000883) | 1.80262332 |
| 125 | Vertebral arch anomaly (HP:0008438) | 1.80087152 |
| 126 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.79729689 |
| 127 | Embryonal renal neoplasm (HP:0011794) | 1.78398459 |
| 128 | Multiple enchondromatosis (HP:0005701) | 1.78025050 |
| 129 | Abnormality of the calcaneus (HP:0008364) | 1.77498845 |
| 130 | Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) | 1.77119561 |
| 131 | Short 1st metacarpal (HP:0010034) | 1.77119561 |
| 132 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 1.77022289 |
| 133 | Angiofibromas (HP:0010615) | 1.76382229 |
| 134 | Adenoma sebaceum (HP:0009720) | 1.76382229 |
| 135 | Abnormality of chromosome segregation (HP:0002916) | 1.75823132 |
| 136 | Fused cervical vertebrae (HP:0002949) | 1.75370232 |
| 137 | Metaphyseal cupping (HP:0003021) | 1.74923828 |
| 138 | Annular pancreas (HP:0001734) | 1.74689186 |
| 139 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.74321430 |
| 140 | Abnormal lung lobation (HP:0002101) | 1.73024997 |
| 141 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 1.72333104 |
| 142 | Ectopic kidney (HP:0000086) | 1.72330307 |
| 143 | Hypochromic microcytic anemia (HP:0004840) | 1.72044008 |
| 144 | Vertebral clefting (HP:0008428) | 1.71460694 |
| 145 | Abnormality of the antihelix (HP:0009738) | 1.71060802 |
| 146 | Overriding aorta (HP:0002623) | 1.70660400 |
| 147 | Cafe-au-lait spot (HP:0000957) | 1.68798104 |
| 148 | Breast aplasia (HP:0100783) | 1.68643613 |
| 149 | Skull defect (HP:0001362) | 1.68558939 |
| 150 | Myokymia (HP:0002411) | 1.68360016 |
| 151 | Hepatoblastoma (HP:0002884) | 1.67999397 |
| 152 | Generalized hypotonia (HP:0001290) | 1.66376024 |
| 153 | Morphological abnormality of the middle ear (HP:0008609) | 1.65128718 |
| 154 | Synostosis of carpal bones (HP:0005048) | 1.61943364 |
| 155 | Abnormality of the parietal bone (HP:0002696) | 1.59509846 |
| 156 | Broad palm (HP:0001169) | 1.59357567 |
| 157 | Enlarged penis (HP:0000040) | 1.59010698 |
| 158 | Bifid tongue (HP:0010297) | 1.58749444 |
| 159 | Abnormality of the intervertebral disk (HP:0005108) | 1.58538388 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK12 | 5.32050933 |
| 2 | CDC7 | 3.50383576 |
| 3 | ICK | 3.16710319 |
| 4 | MAP3K10 | 2.63541085 |
| 5 | FGFR2 | 2.58320123 |
| 6 | NEK2 | 2.48080334 |
| 7 | TTK | 2.38679935 |
| 8 | BUB1 | 2.27156667 |
| 9 | WEE1 | 2.26519348 |
| 10 | TYRO3 | 2.23255369 |
| 11 | CDK7 | 2.19180883 |
| 12 | EEF2K | 2.17522924 |
| 13 | RPS6KB2 | 2.10600101 |
| 14 | NTRK1 | 2.06338572 |
| 15 | EPHA2 | 2.02703541 |
| 16 | TNIK | 2.02315980 |
| 17 | NEK1 | 1.99784824 |
| 18 | LATS2 | 1.95970292 |
| 19 | CASK | 1.87031811 |
| 20 | TAF1 | 1.84383985 |
| 21 | MARK1 | 1.79708785 |
| 22 | NTRK2 | 1.74935449 |
| 23 | SMG1 | 1.72580237 |
| 24 | PLK1 | 1.70391388 |
| 25 | CDK19 | 1.69551091 |
| 26 | DDR2 | 1.67843736 |
| 27 | CHEK2 | 1.66896224 |
| 28 | VRK2 | 1.63651610 |
| 29 | BRD4 | 1.62486698 |
| 30 | CAMK1G | 1.54842302 |
| 31 | MKNK1 | 1.52344364 |
| 32 | PKN2 | 1.51776210 |
| 33 | SRPK1 | 1.51269615 |
| 34 | CAMK1D | 1.45812252 |
| 35 | ALK | 1.44218987 |
| 36 | TSSK6 | 1.44141674 |
| 37 | PDGFRA | 1.43055547 |
| 38 | DYRK3 | 1.43000454 |
| 39 | CDK4 | 1.42095025 |
| 40 | LATS1 | 1.41770568 |
| 41 | MTOR | 1.38501184 |
| 42 | CHEK1 | 1.37750010 |
| 43 | ATR | 1.37066941 |
| 44 | MKNK2 | 1.30867996 |
| 45 | EPHA4 | 1.30304803 |
| 46 | PASK | 1.26675563 |
| 47 | PAK4 | 1.25055220 |
| 48 | AURKB | 1.15376065 |
| 49 | FGFR4 | 1.14746205 |
| 50 | CDK2 | 1.11684426 |
| 51 | CDK6 | 1.09736658 |
| 52 | PLK4 | 1.06254591 |
| 53 | BMX | 1.05598377 |
| 54 | BCR | 1.04924680 |
| 55 | MAP3K8 | 1.01136073 |
| 56 | STK10 | 1.00515674 |
| 57 | ATM | 0.98614741 |
| 58 | AURKA | 0.97954100 |
| 59 | UHMK1 | 0.97429795 |
| 60 | AKT3 | 0.95463218 |
| 61 | MATK | 0.95303437 |
| 62 | MAP3K4 | 0.94561117 |
| 63 | TLK1 | 0.91716788 |
| 64 | TRIB3 | 0.88593390 |
| 65 | AKT2 | 0.87306550 |
| 66 | MAP3K6 | 0.84091948 |
| 67 | DYRK1B | 0.84085122 |
| 68 | PLK3 | 0.83368250 |
| 69 | TESK2 | 0.81821087 |
| 70 | CDK1 | 0.80590813 |
| 71 | EPHB2 | 0.79241043 |
| 72 | PNCK | 0.79010784 |
| 73 | STK38L | 0.77007861 |
| 74 | CDK15 | 0.75965547 |
| 75 | FGFR1 | 0.74749612 |
| 76 | SGK494 | 0.72581021 |
| 77 | SGK223 | 0.72581021 |
| 78 | CDK18 | 0.72365173 |
| 79 | TGFBR1 | 0.71690020 |
| 80 | CSNK1E | 0.71091529 |
| 81 | KSR1 | 0.69972024 |
| 82 | DYRK2 | 0.67812365 |
| 83 | GRK6 | 0.67782305 |
| 84 | ACVR1B | 0.67680965 |
| 85 | PRKCI | 0.67441724 |
| 86 | NME1 | 0.67313107 |
| 87 | STK4 | 0.66858548 |
| 88 | FGR | 0.66188759 |
| 89 | PRKD3 | 0.66147447 |
| 90 | STK3 | 0.64708231 |
| 91 | PIM1 | 0.64378845 |
| 92 | PAK2 | 0.62323662 |
| 93 | DYRK1A | 0.61875127 |
| 94 | CDK14 | 0.59067312 |
| 95 | PAK1 | 0.58147696 |
| 96 | MINK1 | 0.57372689 |
| 97 | CSNK1D | 0.57078992 |
| 98 | CSNK1G2 | 0.56530338 |
| 99 | FLT3 | 0.55791323 |
| 100 | MAPK14 | 0.54011606 |
| 101 | STK11 | 0.53550023 |
| 102 | RIPK1 | 0.53137312 |
| 103 | MET | 0.53114746 |
| 104 | CSNK1G1 | 0.52786635 |
| 105 | MELK | 0.52466808 |
| 106 | CDC42BPA | 0.51626327 |
| 107 | CSNK2A2 | 0.51388459 |
| 108 | ZAK | 0.51047056 |
| 109 | MAP2K7 | 0.50397603 |
| 110 | VRK1 | 0.50008196 |
| 111 | SCYL2 | 0.49828755 |
| 112 | NTRK3 | 0.49436038 |
| 113 | PRKDC | 0.48505444 |
| 114 | GSK3B | 0.48311073 |
| 115 | RPS6KA1 | 0.48033132 |
| 116 | PRKD2 | 0.47643443 |
| 117 | YES1 | 0.46882836 |
| 118 | BRSK1 | 0.46508874 |
| 119 | PTK6 | 0.46489253 |
| 120 | DMPK | 0.46129091 |
| 121 | STK24 | 0.45964016 |
| 122 | BRAF | 0.45902757 |
| 123 | MAPK1 | 0.45580996 |
| 124 | ERBB2 | 0.45435411 |
| 125 | CDK5 | 0.44669855 |
| 126 | PRKCG | 0.44022399 |
| 127 | AKT1 | 0.43756432 |
| 128 | RPS6KL1 | 0.42242790 |
| 129 | RPS6KC1 | 0.42242790 |
| 130 | MAPK9 | 0.42221466 |
| 131 | MAPK10 | 0.42103974 |
| 132 | CAMK4 | 0.41906351 |
| 133 | MAPKAPK3 | 0.39574321 |
| 134 | BRSK2 | 0.38122788 |
| 135 | MAP3K11 | 0.36331842 |
| 136 | CDK11A | 0.35770573 |
| 137 | PTK2 | 0.35514422 |
| 138 | DAPK1 | 0.35418087 |
| 139 | MAP3K9 | 0.34977769 |
| 140 | HIPK2 | 0.34608367 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Mismatch repair_Homo sapiens_hsa03430 | 4.01217354 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 3.85734933 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.51972877 |
| 4 | Spliceosome_Homo sapiens_hsa03040 | 3.50999754 |
| 5 | RNA transport_Homo sapiens_hsa03013 | 3.32789374 |
| 6 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.83100517 |
| 7 | Base excision repair_Homo sapiens_hsa03410 | 2.82445295 |
| 8 | Cell cycle_Homo sapiens_hsa04110 | 2.71113794 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.37778307 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.34076254 |
| 11 | Basal cell carcinoma_Homo sapiens_hsa05217 | 2.28317793 |
| 12 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.23202888 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 2.13873380 |
| 14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.00530820 |
| 15 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.97972248 |
| 16 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.93621347 |
| 17 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.88404115 |
| 18 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.82726391 |
| 19 | Ribosome_Homo sapiens_hsa03010 | 1.80873174 |
| 20 | RNA polymerase_Homo sapiens_hsa03020 | 1.78472208 |
| 21 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.70544582 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.63473603 |
| 23 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.56000768 |
| 24 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.55990898 |
| 25 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.53345002 |
| 26 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.50706181 |
| 27 | Basal transcription factors_Homo sapiens_hsa03022 | 1.48592253 |
| 28 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.44480182 |
| 29 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.28763497 |
| 30 | Adherens junction_Homo sapiens_hsa04520 | 1.27727586 |
| 31 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.26478094 |
| 32 | Colorectal cancer_Homo sapiens_hsa05210 | 1.25347229 |
| 33 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.21709508 |
| 34 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.21457647 |
| 35 | Nicotine addiction_Homo sapiens_hsa05033 | 1.19258815 |
| 36 | Thyroid cancer_Homo sapiens_hsa05216 | 1.18256826 |
| 37 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.17787781 |
| 38 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.16734786 |
| 39 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.16303086 |
| 40 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.15868668 |
| 41 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.14751291 |
| 42 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.13591301 |
| 43 | Lysine degradation_Homo sapiens_hsa00310 | 1.11152256 |
| 44 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.10905461 |
| 45 | Bladder cancer_Homo sapiens_hsa05219 | 1.09781484 |
| 46 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.07821520 |
| 47 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.07447329 |
| 48 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.05502332 |
| 49 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.99585794 |
| 50 | Tight junction_Homo sapiens_hsa04530 | 0.98049252 |
| 51 | HTLV-I infection_Homo sapiens_hsa05166 | 0.95951082 |
| 52 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.90211201 |
| 53 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.88322515 |
| 54 | Endometrial cancer_Homo sapiens_hsa05213 | 0.85717240 |
| 55 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.82478242 |
| 56 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.82292285 |
| 57 | Pathways in cancer_Homo sapiens_hsa05200 | 0.80532550 |
| 58 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.78897039 |
| 59 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.78813567 |
| 60 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.78724282 |
| 61 | Alcoholism_Homo sapiens_hsa05034 | 0.75945985 |
| 62 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.73392032 |
| 63 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.71913838 |
| 64 | Cocaine addiction_Homo sapiens_hsa05030 | 0.69255714 |
| 65 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.67897148 |
| 66 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.67587702 |
| 67 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.63224199 |
| 68 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.63118581 |
| 69 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.62161119 |
| 70 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.61766446 |
| 71 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.59036444 |
| 72 | Prostate cancer_Homo sapiens_hsa05215 | 0.57012540 |
| 73 | Melanoma_Homo sapiens_hsa05218 | 0.56642910 |
| 74 | Taste transduction_Homo sapiens_hsa04742 | 0.56600133 |
| 75 | Long-term depression_Homo sapiens_hsa04730 | 0.56589021 |
| 76 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.56392250 |
| 77 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.55821805 |
| 78 | Viral myocarditis_Homo sapiens_hsa05416 | 0.55453700 |
| 79 | Circadian entrainment_Homo sapiens_hsa04713 | 0.55252090 |
| 80 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.54954083 |
| 81 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.54856191 |
| 82 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.54209893 |
| 83 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.53771045 |
| 84 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.53231844 |
| 85 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.53216573 |
| 86 | GABAergic synapse_Homo sapiens_hsa04727 | 0.52487682 |
| 87 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.52407828 |
| 88 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.51072124 |
| 89 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.49687338 |
| 90 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.48900978 |
| 91 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.48573076 |
| 92 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.47239215 |
| 93 | Proteasome_Homo sapiens_hsa03050 | 0.45918379 |
| 94 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.45573616 |
| 95 | Long-term potentiation_Homo sapiens_hsa04720 | 0.44862062 |
| 96 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.44697780 |
| 97 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.44128041 |
| 98 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.43034356 |
| 99 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.41632462 |
| 100 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.41594834 |
| 101 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.41238485 |
| 102 | Axon guidance_Homo sapiens_hsa04360 | 0.40724609 |
| 103 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.40406747 |
| 104 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.39900879 |
| 105 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.39823430 |
| 106 | Purine metabolism_Homo sapiens_hsa00230 | 0.39208411 |
| 107 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.39092666 |
| 108 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.38947199 |
| 109 | Focal adhesion_Homo sapiens_hsa04510 | 0.38485142 |
| 110 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.38183451 |
| 111 | Melanogenesis_Homo sapiens_hsa04916 | 0.37325768 |
| 112 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.36224527 |
| 113 | Glioma_Homo sapiens_hsa05214 | 0.36182083 |
| 114 | Galactose metabolism_Homo sapiens_hsa00052 | 0.35021677 |
| 115 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.35014064 |
| 116 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.33512454 |
| 117 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.33416733 |
| 118 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.33000484 |
| 119 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.32746020 |
| 120 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.32488055 |
| 121 | Carbon metabolism_Homo sapiens_hsa01200 | 0.31849569 |
| 122 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.31627433 |
| 123 | Gap junction_Homo sapiens_hsa04540 | 0.29169893 |
| 124 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.28996760 |
| 125 | Apoptosis_Homo sapiens_hsa04210 | 0.28414455 |
| 126 | Sulfur relay system_Homo sapiens_hsa04122 | 0.27759582 |
| 127 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.26242001 |
| 128 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.26143344 |
| 129 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.26086952 |
| 130 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.25907807 |
| 131 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.25159392 |

