RCSD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.95315525
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.78674754
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.78674754
4regulation of gamma-delta T cell differentiation (GO:0045586)5.63770672
5antigen processing and presentation of endogenous antigen (GO:0019883)5.54288797
6regulation of gamma-delta T cell activation (GO:0046643)5.36647002
7positive regulation of B cell differentiation (GO:0045579)5.04689377
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.92738744
9B cell receptor signaling pathway (GO:0050853)4.69857834
10regulation of B cell differentiation (GO:0045577)4.49407640
11regulation of B cell receptor signaling pathway (GO:0050855)4.44454930
12positive thymic T cell selection (GO:0045059)4.24740345
13negative regulation of cell killing (GO:0031342)4.22207638
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.22207638
15NIK/NF-kappaB signaling (GO:0038061)4.21333124
16negative T cell selection (GO:0043383)4.15345500
17detection of other organism (GO:0098543)4.11221443
18detection of bacterium (GO:0016045)4.03809024
19leukocyte aggregation (GO:0070486)3.99901514
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97067340
21negative regulation of T cell mediated immunity (GO:0002710)3.96349389
22regulation of interleukin-12 biosynthetic process (GO:0045075)3.87201310
23negative thymic T cell selection (GO:0045060)3.85887631
24positive T cell selection (GO:0043368)3.84869265
25macrophage activation involved in immune response (GO:0002281)3.83699781
26response to peptidoglycan (GO:0032494)3.77184396
27negative regulation of phagocytosis (GO:0050765)3.74994628
28T cell selection (GO:0045058)3.70954217
29V(D)J recombination (GO:0033151)3.69437543
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.69224266
31T cell homeostasis (GO:0043029)3.67965464
32T cell migration (GO:0072678)3.65133205
33negative regulation of interleukin-12 production (GO:0032695)3.61105339
34response to interleukin-15 (GO:0070672)3.59467403
35antigen receptor-mediated signaling pathway (GO:0050851)3.56000100
36thymic T cell selection (GO:0045061)3.48229320
37cellular response to zinc ion (GO:0071294)3.46423603
38regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.45734451
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.44913357
40regulation of dendritic cell antigen processing and presentation (GO:0002604)3.40523189
41lymphocyte homeostasis (GO:0002260)3.38422570
42B cell mediated immunity (GO:0019724)3.36110381
43negative regulation of leukocyte mediated immunity (GO:0002704)3.35442441
44myeloid cell activation involved in immune response (GO:0002275)3.32283451
45myeloid dendritic cell activation (GO:0001773)3.28476767
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.28355635
47cellular extravasation (GO:0045123)3.27796427
48neutrophil activation (GO:0042119)3.27677768
49positive regulation of interleukin-2 production (GO:0032743)3.26911571
50detection of external biotic stimulus (GO:0098581)3.26206197
51regulation of antigen processing and presentation (GO:0002577)3.24914752
52T cell receptor signaling pathway (GO:0050852)3.23131010
53negative regulation of erythrocyte differentiation (GO:0045647)3.21240305
54respiratory burst (GO:0045730)3.16298279
55tolerance induction (GO:0002507)3.16130106
56cellular response to interleukin-15 (GO:0071350)3.16000180
57natural killer cell differentiation (GO:0001779)3.15867329
58response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.14759862
59response to host immune response (GO:0052572)3.14759862
60interferon-gamma production (GO:0032609)3.13465973
61regulation of T cell receptor signaling pathway (GO:0050856)3.11129903
62response to muramyl dipeptide (GO:0032495)3.09992465
63microglial cell activation (GO:0001774)3.09367719
64regulation of mast cell degranulation (GO:0043304)3.09228978
65negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08716171
66negative regulation of T-helper cell differentiation (GO:0045623)3.08716171
67positive regulation of alpha-beta T cell proliferation (GO:0046641)3.06634951
68activated T cell proliferation (GO:0050798)3.06116419
69B cell proliferation (GO:0042100)3.05919916
70leukocyte homeostasis (GO:0001776)3.04641234
71immunoglobulin mediated immune response (GO:0016064)3.03463543
72mucosal-associated lymphoid tissue development (GO:0048537)3.02585212
73Peyers patch development (GO:0048541)3.02585212
74antigen processing and presentation via MHC class Ib (GO:0002475)3.02341109
75neutrophil activation involved in immune response (GO:0002283)3.02129611
76regulation of alpha-beta T cell proliferation (GO:0046640)3.01747415
77mast cell activation (GO:0045576)3.01578484
78regulation of germinal center formation (GO:0002634)3.00729494
79leukocyte degranulation (GO:0043299)2.99354475
80T cell costimulation (GO:0031295)2.98677948
81mature B cell differentiation (GO:0002335)2.96946841
82positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.94765669
83myeloid dendritic cell differentiation (GO:0043011)2.94551406
84granulocyte activation (GO:0036230)2.93338359
85positive regulation of mast cell activation (GO:0033005)2.93095762
86negative regulation of granulocyte differentiation (GO:0030853)2.93056088
87lymphocyte costimulation (GO:0031294)2.92881887
88regulation of necroptotic process (GO:0060544)2.92845512
89positive regulation of interferon-alpha production (GO:0032727)2.90723507
90regulation of T-helper 1 cell differentiation (GO:0045625)2.90385451
91regulation of mast cell activation (GO:0033003)2.89748268
92B cell homeostasis (GO:0001782)2.88577697
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88193393
94germinal center formation (GO:0002467)2.87115781
95response to host defenses (GO:0052200)2.87003556
96response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.87003556
97response to host (GO:0075136)2.87003556
98regulation of interferon-alpha production (GO:0032647)2.86763729
99regulation of T cell mediated cytotoxicity (GO:0001914)2.86402956
100detection of biotic stimulus (GO:0009595)2.85718270
101JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.85477478
102regulation of interferon-beta biosynthetic process (GO:0045357)2.85304169
103positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.84817918
104regulation of T cell tolerance induction (GO:0002664)2.79752010
105natural killer cell activation (GO:0030101)2.79602181
106defense response to protozoan (GO:0042832)2.78964082
107immune response-activating cell surface receptor signaling pathway (GO:0002429)2.78035796
108Arp2/3 complex-mediated actin nucleation (GO:0034314)2.77464025
109positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.77459910
110positive regulation of antigen processing and presentation (GO:0002579)2.76549553
111regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.75674761
112mononuclear cell proliferation (GO:0032943)2.74543678
113leukocyte cell-cell adhesion (GO:0007159)2.72453709
114lymphocyte proliferation (GO:0046651)2.72391186
115interferon-gamma-mediated signaling pathway (GO:0060333)2.71229350
116response to protozoan (GO:0001562)2.70270034
117positive regulation of B cell activation (GO:0050871)2.69892517
118positive regulation by organism of defense response of other organism involved in symbiotic interact2.69832304
119modulation by symbiont of host immune response (GO:0052553)2.69832304
120positive regulation by symbiont of host defense response (GO:0052509)2.69832304
121modulation by symbiont of host defense response (GO:0052031)2.69832304
122modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.69832304
123modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.69832304
124positive regulation of granulocyte differentiation (GO:0030854)2.69413050
125hepatocyte apoptotic process (GO:0097284)2.69392649
126T cell proliferation (GO:0042098)2.68971975
127lymph node development (GO:0048535)2.68845536
128regulation of response to interferon-gamma (GO:0060330)2.66782979
129response to type I interferon (GO:0034340)2.66735249
130regulation of regulatory T cell differentiation (GO:0045589)2.65092111
131regulation of granulocyte differentiation (GO:0030852)2.64960346
132regulation of type I interferon-mediated signaling pathway (GO:0060338)2.62452594
133negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.60456875
134positive regulation of histone deacetylation (GO:0031065)2.59717538
135regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.59015812
136type I interferon signaling pathway (GO:0060337)2.58976245
137cellular response to type I interferon (GO:0071357)2.58976245
138regulation of interleukin-2 biosynthetic process (GO:0045076)2.57879173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.22474036
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.78150972
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.69159715
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.48364856
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.62309650
6MYC_22102868_ChIP-Seq_BL_Human3.51507216
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.51201372
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44186601
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.41458590
10VDR_21846776_ChIP-Seq_THP-1_Human3.06191838
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.05080168
12SCL_19346495_ChIP-Seq_HPC-7_Human2.82543361
13RUNX_20019798_ChIP-Seq_JUKART_Human2.79634992
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.75285508
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.74637050
16* MYB_26560356_Chip-Seq_TH2_Human2.71230200
17* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.66849881
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65150470
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.63920529
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.61619019
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.60472532
22* MAF_26560356_Chip-Seq_TH1_Human2.58614503
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53459465
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41697918
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39967365
26* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34951606
27* UTX_26944678_Chip-Seq_JUKART_Human2.33432165
28* MYB_26560356_Chip-Seq_TH1_Human2.33135362
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28403400
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26173779
31SPI1_23547873_ChIP-Seq_NB4_Human2.23779718
32* TCF7_22412390_ChIP-Seq_EML_Mouse2.18020229
33* VDR_24763502_ChIP-Seq_THP-1_Human2.17587296
34* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05480643
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.02248513
36* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99835537
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.96792553
38SPI1_23127762_ChIP-Seq_K562_Human1.81584356
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78226412
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73039204
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71660523
42CIITA_25753668_ChIP-Seq_RAJI_Human1.70907767
43* GATA3_27048872_Chip-Seq_THYMUS_Human1.67268300
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66361376
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65876768
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64595994
47MAF_26560356_Chip-Seq_TH2_Human1.58785086
48KDM2B_26808549_Chip-Seq_DND41_Human1.57700632
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52514152
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50991535
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49552299
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47597746
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46970196
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46796621
55GATA1_22025678_ChIP-Seq_K562_Human1.46600168
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45475990
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.42389601
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.37114501
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35454385
60* PU_27001747_Chip-Seq_BMDM_Mouse1.34263691
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28674099
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26968450
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26369730
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25047538
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22870660
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21769503
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21441220
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21193453
69* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20998724
70* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20391939
71* GATA1_19941826_ChIP-Seq_K562_Human1.19442631
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18494555
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17766298
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16679819
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13334233
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12919357
77* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12258060
78BCL6_27268052_Chip-Seq_Bcells_Human1.10992112
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.07548197
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05837707
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05828669
82* GATA3_26560356_Chip-Seq_TH2_Human1.02331437
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00830352
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00722315
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96861881
86SPI1_20517297_ChIP-Seq_HL60_Human0.95063853
87BCOR_27268052_Chip-Seq_Bcells_Human0.94618762
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94424609
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93809335
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91367215
91E2F1_21310950_ChIP-Seq_MCF-7_Human0.91298735
92* VDR_24787735_ChIP-Seq_THP-1_Human0.90768232
93NCOR1_26117541_ChIP-Seq_K562_Human0.90439782
94FOXP3_21729870_ChIP-Seq_TREG_Human0.89276149
95* ELF1_20517297_ChIP-Seq_JURKAT_Human0.88291986
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.85639096
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85076476
98SMRT_27268052_Chip-Seq_Bcells_Human0.84953896
99VDR_23849224_ChIP-Seq_CD4+_Human0.84788587
100P300_27268052_Chip-Seq_Bcells_Human0.83519945
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.83200035
102KDM2B_26808549_Chip-Seq_JURKAT_Human0.83182586
103FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82828941
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80549897
105CTCF_21964334_ChIP-Seq_BJAB-B_Human0.78799793
106* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76764724
107* GATA2_21666600_ChIP-Seq_HMVEC_Human0.73036737
108RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72218941
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71858595
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71575260
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70020004
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69819275
113* GATA2_19941826_ChIP-Seq_K562_Human0.69032191
114GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68351756
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.67708055

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.93494308
2MP0000685_abnormal_immune_system3.52764990
3MP0005671_abnormal_response_to3.27213944
4MP0001800_abnormal_humoral_immune3.18786039
5MP0001790_abnormal_immune_system3.03702657
6MP0005387_immune_system_phenotype3.03702657
7MP0003763_abnormal_thymus_physiology2.96801569
8MP0002166_altered_tumor_susceptibility2.83167303
9MP0002396_abnormal_hematopoietic_system2.81802671
10MP0009785_altered_susceptibility_to2.73775220
11MP0002452_abnormal_antigen_presenting2.72185385
12MP0002420_abnormal_adaptive_immunity2.58795468
13MP0005000_abnormal_immune_tolerance2.56686724
14MP0001819_abnormal_immune_cell2.56469297
15MP0002723_abnormal_immune_serum2.56120892
16MP0002398_abnormal_bone_marrow2.56093284
17MP0003303_peritoneal_inflammation2.47531858
18MP0003436_decreased_susceptibility_to2.46264686
19MP0009278_abnormal_bone_marrow2.40276206
20MP0005025_abnormal_response_to2.30495033
21MP0000716_abnormal_immune_system2.28410439
22MP0004808_abnormal_hematopoietic_stem2.22821908
23MP0002419_abnormal_innate_immunity2.20973846
24MP0002006_tumorigenesis2.16545186
25MP0002148_abnormal_hypersensitivity_rea2.14261039
26MP0000689_abnormal_spleen_morphology2.11512449
27MP0004510_myositis2.11051775
28MP0000703_abnormal_thymus_morphology2.07339118
29MP0002722_abnormal_immune_system2.06622727
30MP0002405_respiratory_system_inflammati1.97732439
31MP0002429_abnormal_blood_cell1.91728779
32MP0010155_abnormal_intestine_physiology1.91377889
33MP0001853_heart_inflammation1.90816595
34MP0005464_abnormal_platelet_physiology1.89205587
35MP0005397_hematopoietic_system_phenotyp1.86885703
36MP0001545_abnormal_hematopoietic_system1.86885703
37MP0003300_gastrointestinal_ulcer1.84517110
38MP0001873_stomach_inflammation1.84073316
39MP0005451_abnormal_body_composition1.74400237
40MP0009333_abnormal_splenocyte_physiolog1.71632359
41MP0004947_skin_inflammation1.70695985
42MP0001845_abnormal_inflammatory_respons1.55373032
43MP0003828_pulmonary_edema1.52087997
44MP0002138_abnormal_hepatobiliary_system1.48547152
45MP0003724_increased_susceptibility_to1.48498823
46MP0006082_CNS_inflammation1.44719910
47MP0002933_joint_inflammation1.38173283
48MP0001879_abnormal_lymphatic_vessel1.32017146
49MP0004381_abnormal_hair_follicle1.31876046
50MP0008057_abnormal_DNA_replication1.28470134
51MP0000465_gastrointestinal_hemorrhage1.28286374
52MP0005174_abnormal_tail_pigmentation1.25381955
53MP0010094_abnormal_chromosome_stability1.24473721
54MP0003866_abnormal_defecation1.22963677
55MP0000490_abnormal_crypts_of1.16244340
56MP0008469_abnormal_protein_level1.08979200
57MP0002009_preneoplasia1.07883947
58MP0001533_abnormal_skeleton_physiology1.06632692
59MP0008260_abnormal_autophagy1.04628365
60MP0002019_abnormal_tumor_incidence1.04184043
61MP0001986_abnormal_taste_sensitivity1.00629629
62MP0003646_muscle_fatigue1.00566791
63MP0005310_abnormal_salivary_gland0.99390913
64MP0003077_abnormal_cell_cycle0.96644143
65MP0000858_altered_metastatic_potential0.95394217
66MP0000015_abnormal_ear_pigmentation0.95382888
67MP0003448_altered_tumor_morphology0.95199554
68MP0010352_gastrointestinal_tract_polyps0.94686630
69MP0003191_abnormal_cellular_cholesterol0.92795805
70MP0004883_abnormal_blood_vessel0.91780971
71MP0002095_abnormal_skin_pigmentation0.89356202
72MP0010630_abnormal_cardiac_muscle0.89116344
73MP0004084_abnormal_cardiac_muscle0.88473818
74MP0000343_altered_response_to0.87578679
75MP0005076_abnormal_cell_differentiation0.85818934
76MP0003183_abnormal_peptide_metabolism0.83137901
77MP0003656_abnormal_erythrocyte_physiolo0.82975993
78MP0002332_abnormal_exercise_endurance0.82425375
79MP0008007_abnormal_cellular_replicative0.82404267
80MP0002132_abnormal_respiratory_system0.81770120
81MP0003806_abnormal_nucleotide_metabolis0.80937591
82MP0009764_decreased_sensitivity_to0.80702102
83MP0005166_decreased_susceptibility_to0.79798708
84MP0005075_abnormal_melanosome_morpholog0.78253607
85MP0001663_abnormal_digestive_system0.77859200
86MP0003693_abnormal_embryo_hatching0.76867731
87MP0000569_abnormal_digit_pigmentation0.76612917
88MP0003075_altered_response_to0.74886399
89MP0000249_abnormal_blood_vessel0.74876296
90MP0000767_abnormal_smooth_muscle0.74205042
91MP0003045_fibrosis0.71312700
92MP0003566_abnormal_cell_adhesion0.70174227
93MP0003279_aneurysm0.69805919
94MP0001851_eye_inflammation0.69273574
95MP0005058_abnormal_lysosome_morphology0.68219014
96MP0006054_spinal_hemorrhage0.68020948
97MP0010307_abnormal_tumor_latency0.65670649
98MP0003172_abnormal_lysosome_physiology0.65657837
99MP0002998_abnormal_bone_remodeling0.65524952
100MP0003111_abnormal_nucleus_morphology0.65347660
101MP0004036_abnormal_muscle_relaxation0.64669075
102MP0008058_abnormal_DNA_repair0.64444571
103MP0004130_abnormal_muscle_cell0.64360436
104MP0000313_abnormal_cell_death0.63692427
105MP0003690_abnormal_glial_cell0.63629754
106MP0009765_abnormal_xenobiotic_induced0.63056537
107MP0002928_abnormal_bile_duct0.60825163
108MP0008874_decreased_physiological_sensi0.58256083
109MP0004087_abnormal_muscle_fiber0.57412756
110MP0008004_abnormal_stomach_pH0.57384948
111MP0000604_amyloidosis0.56922881
112MP0005164_abnormal_response_to0.56821267
113MP0005266_abnormal_metabolism0.56534385
114MP0009763_increased_sensitivity_to0.56520777
115MP0002693_abnormal_pancreas_physiology0.55829515
116MP0003943_abnormal_hepatobiliary_system0.55021742
117MP0005390_skeleton_phenotype0.55002397
118MP0001544_abnormal_cardiovascular_syste0.54918920
119MP0005385_cardiovascular_system_phenoty0.54918920
120MP0005023_abnormal_wound_healing0.54662685
121MP0008961_abnormal_basal_metabolism0.54556716
122MP0004484_altered_response_of0.51487717
123MP0005376_homeostasis/metabolism_phenot0.49005991
124MP0003221_abnormal_cardiomyocyte_apopto0.48950632
125MP0002277_abnormal_respiratory_mucosa0.48618622
126MP0003795_abnormal_bone_structure0.46971433
127MP0005535_abnormal_body_temperature0.46432867
128MP0009115_abnormal_fat_cell0.45581205

Predicted human phenotypes

RankGene SetZ-score
1Recurrent viral infections (HP:0004429)5.39438487
2Panhypogammaglobulinemia (HP:0003139)5.33502837
3Agammaglobulinemia (HP:0004432)5.03282013
4B lymphocytopenia (HP:0010976)4.94891998
5Abnormality of B cell number (HP:0010975)4.94891998
6T lymphocytopenia (HP:0005403)4.81738627
7Thyroiditis (HP:0100646)4.70457147
8Abnormality of T cell number (HP:0011839)4.67870578
9Recurrent fungal infections (HP:0002841)4.65849478
10Recurrent abscess formation (HP:0002722)4.51107976
11Cellulitis (HP:0100658)4.31779691
12Chronic otitis media (HP:0000389)4.27216434
13Recurrent bacterial skin infections (HP:0005406)4.11178005
14Meningitis (HP:0001287)4.11029731
15Eosinophilia (HP:0001880)4.00718342
16Severe combined immunodeficiency (HP:0004430)4.00004976
17Recurrent bronchitis (HP:0002837)3.99820516
18Eczematoid dermatitis (HP:0000976)3.95025301
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.82715707
20IgM deficiency (HP:0002850)3.81126489
21Papilloma (HP:0012740)3.77507404
22Verrucae (HP:0200043)3.77507404
23Abnormality of T cells (HP:0002843)3.70167734
24Combined immunodeficiency (HP:0005387)3.60938599
25Granulocytopenia (HP:0001913)3.55113064
26Elevated erythrocyte sedimentation rate (HP:0003565)3.53831160
27Abnormality of the fingertips (HP:0001211)3.49891234
28Myositis (HP:0100614)3.47721900
29Gastrointestinal infarctions (HP:0005244)3.44891567
30Hypoplasia of the thymus (HP:0000778)3.38558808
31Colitis (HP:0002583)3.35045848
32Inflammation of the large intestine (HP:0002037)3.33700037
33Gastrointestinal inflammation (HP:0004386)3.27324277
34Abnormality of eosinophils (HP:0001879)3.27099009
35Recurrent cutaneous fungal infections (HP:0011370)3.22077386
36Chronic mucocutaneous candidiasis (HP:0002728)3.22077386
37Mediastinal lymphadenopathy (HP:0100721)3.20164626
38Spontaneous hematomas (HP:0007420)3.17268593
39Autoimmune hemolytic anemia (HP:0001890)3.11808125
40IgG deficiency (HP:0004315)3.11771255
41Recurrent skin infections (HP:0001581)3.07039355
42Leukocytosis (HP:0001974)3.01539405
43Gastrointestinal stroma tumor (HP:0100723)2.95927762
44Lymphopenia (HP:0001888)2.91944080
45Thrombocytosis (HP:0001894)2.91882722
46Osteomyelitis (HP:0002754)2.89659781
47Vasculitis (HP:0002633)2.88499952
48Abnormality of cells of the lymphoid lineage (HP:0012140)2.87312482
49Increased IgM level (HP:0003496)2.84255336
50Nasal polyposis (HP:0100582)2.79778261
51Abnormality of the nasal mucosa (HP:0000433)2.73427677
52Urticaria (HP:0001025)2.72896277
53Chronic sinusitis (HP:0011109)2.70154366
54Abnormality of T cell physiology (HP:0011840)2.69314377
55Autoimmune thrombocytopenia (HP:0001973)2.67673589
56Hematochezia (HP:0002573)2.59912918
57Chronic obstructive pulmonary disease (HP:0006510)2.59912474
58Obstructive lung disease (HP:0006536)2.59912474
59Sepsis (HP:0100806)2.59195660
60Hypoproteinemia (HP:0003075)2.58692989
61Pustule (HP:0200039)2.44931960
62Encephalitis (HP:0002383)2.42459083
63Prolonged bleeding time (HP:0003010)2.41665346
64Retrobulbar optic neuritis (HP:0100654)2.39703452
65Optic neuritis (HP:0100653)2.39703452
66Abnormality of the pleura (HP:0002103)2.38028930
67Orchitis (HP:0100796)2.36463253
68Recurrent sinusitis (HP:0011108)2.35644435
69Chronic diarrhea (HP:0002028)2.34761285
70Lymphoma (HP:0002665)2.34603810
71Pulmonary embolism (HP:0002204)2.34252108
72Abnormality of macrophages (HP:0004311)2.33045790
73IgA deficiency (HP:0002720)2.30645791
74Increased IgE level (HP:0003212)2.29594347
75Chest pain (HP:0100749)2.29427882
76Arterial thrombosis (HP:0004420)2.28549748
77Recurrent pneumonia (HP:0006532)2.27995860
78Stomatitis (HP:0010280)2.26250168
79Pulmonary infiltrates (HP:0002113)2.25310181
80Recurrent gram-negative bacterial infections (HP:0005420)2.24916752
81Episodic fever (HP:0001954)2.23733589
82Gangrene (HP:0100758)2.21475179
83Hypochromic anemia (HP:0001931)2.21014983
84Emphysema (HP:0002097)2.18842875
85Anorexia (HP:0002039)2.15562423
86Skin ulcer (HP:0200042)2.15348078
87Fatigue (HP:0012378)2.14424992
88Recurrent lower respiratory tract infections (HP:0002783)2.11275649
89Periodontitis (HP:0000704)2.09488029
90Hemoptysis (HP:0002105)2.08980433
91Bronchitis (HP:0012387)2.04878202
92Acute hepatic failure (HP:0006554)2.01449491
93Gingivitis (HP:0000230)1.99346206
94Epistaxis (HP:0000421)1.98187422
95Keratoconjunctivitis sicca (HP:0001097)1.96156112
96Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95503939
97Polyneuropathy (HP:0001271)1.94429320
98Aplasia/Hypoplasia of the thymus (HP:0010515)1.93786780
99Subaortic stenosis (HP:0001682)1.92910420
100Abnormality of the left ventricular outflow tract (HP:0011103)1.92910420
101Abnormality of the endocardium (HP:0004306)1.91850795
102Interstitial pulmonary disease (HP:0006530)1.91815908
103Amaurosis fugax (HP:0100576)1.90703482
104Vertigo (HP:0002321)1.90197938
105Hypochromic microcytic anemia (HP:0004840)1.88422852
106Acute myeloid leukemia (HP:0004808)1.85665218
107Bicuspid aortic valve (HP:0001647)1.85218649
108Abnormality of the prostate (HP:0008775)1.84506009
109Restrictive lung disease (HP:0002091)1.83630496
110Skin rash (HP:0000988)1.83072557
111Petechiae (HP:0000967)1.82216119
112Keratoconjunctivitis (HP:0001096)1.77661529
113Viral hepatitis (HP:0006562)1.75071149
114Leukopenia (HP:0001882)1.74337724
115Hypergammaglobulinemia (HP:0010702)1.71664911
116Gingival bleeding (HP:0000225)1.69076481
117Neutropenia (HP:0001875)1.68985716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.70326900
2MAP3K103.27269351
3PRPF4B2.62969444
4TYK22.62031671
5TXK2.49735879
6MAP3K142.41573007
7EEF2K2.35416112
8JAK32.31501092
9BTK2.22470598
10GRK62.21536363
11ZAP702.13852655
12STK102.09538442
13SYK1.99305094
14IRAK41.96896631
15CSF1R1.90030880
16KIT1.89024560
17TEC1.86504928
18ITK1.84268053
19TBK11.83587917
20PKN21.80388904
21FLT31.80382968
22BLK1.74979521
23JAK11.67384431
24IKBKE1.63088465
25RIPK41.62402283
26TGFBR21.59856275
27TTN1.52922959
28IKBKB1.51741153
29CLK11.49751765
30SIK21.42621401
31STK41.40089862
32MAP2K31.39900363
33HCK1.38820347
34MAP3K131.38471467
35CSK1.36245160
36ERN11.35891100
37LCK1.34480313
38BMPR21.33949958
39LRRK21.30566220
40FGFR31.28661559
41TESK21.26126294
42FGFR41.26050062
43NLK1.21200188
44TRIB31.19880307
45PIM11.19834487
46EPHB11.17577409
47MAP3K111.17152856
48FES1.12081525
49CDK121.09919920
50NEK21.08071197
51KDR1.04075558
52LYN1.00596188
53RPS6KA40.97776040
54MARK30.96925359
55CHUK0.96646057
56MAP3K70.95437608
57TRPM70.95437549
58FGR0.95042902
59IRAK30.94241873
60CDK40.92913206
61MAP3K10.88793769
62MAPK120.86223012
63MATK0.84290008
64STK240.82011832
65PTK60.80995714
66RPS6KB20.79565970
67IRAK10.77745602
68TAOK10.75327361
69MAP3K30.73950925
70JAK20.73296721
71SIK30.70249198
72PRKCQ0.69489373
73TAOK20.67291164
74OBSCN0.66957563
75MST40.66731705
76MAPK110.66095623
77MAPK40.65854997
78TGFBR10.65776091
79MARK20.62429321
80DMPK0.60695024
81GRK70.59525086
82NEK90.57921816
83HIPK20.57298397
84MAPK70.56368258
85CDK190.56272682
86YES10.53546560
87MAPKAPK30.53339933
88IRAK20.52183948
89CDK90.52037569
90CDK60.51383750
91TIE10.50885583
92PRKAA20.49804870
93MAP2K60.48941115
94NME20.48178804
95RPS6KA60.48126270
96CDC42BPA0.48094071
97MAP2K20.48084087
98PRKD20.44985827
99TAOK30.43782034
100FYN0.43737458
101MAP3K80.43368142
102PASK0.43096295
103MYLK0.41851182
104MELK0.41713259
105DYRK1B0.41649350
106BRD40.41130012
107KSR20.40804709
108PDPK10.40400259
109ZAK0.39320729
110ATR0.38317725
111TNK20.38132136
112CAMKK20.37271132
113MAP3K50.37112544
114CAMKK10.36661331
115RPS6KC10.36512273
116RPS6KL10.36512273
117TLK10.36478301
118SMG10.36133289
119PDGFRB0.34985077
120ABL10.34575259
121STK110.34487960
122CDC70.33273350
123BCKDK0.32358741
124PRKCH0.32055742
125PDK10.30588359
126SGK30.28477913
127CCNB10.27635168
128PRKD10.26967823
129MAPK30.25368791
130DYRK30.24249754
131PIK3CG0.24156122

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.89847069
2B cell receptor signaling pathway_Homo sapiens_hsa046623.07226687
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.82797854
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.50515859
5Leishmaniasis_Homo sapiens_hsa051402.45660418
6Measles_Homo sapiens_hsa051622.27320634
7Osteoclast differentiation_Homo sapiens_hsa043802.27103903
8Hematopoietic cell lineage_Homo sapiens_hsa046402.22731437
9T cell receptor signaling pathway_Homo sapiens_hsa046602.21880391
10Antigen processing and presentation_Homo sapiens_hsa046122.02256349
11Non-homologous end-joining_Homo sapiens_hsa034501.98213669
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.97634491
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89203977
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78525904
15Herpes simplex infection_Homo sapiens_hsa051681.67857821
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66451754
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64986524
18Viral myocarditis_Homo sapiens_hsa054161.60931845
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60036266
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58225824
21Acute myeloid leukemia_Homo sapiens_hsa052211.57946134
22Toxoplasmosis_Homo sapiens_hsa051451.57279024
23Allograft rejection_Homo sapiens_hsa053301.55145029
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.51678228
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.51647670
26DNA replication_Homo sapiens_hsa030301.45841869
27Chemokine signaling pathway_Homo sapiens_hsa040621.44464117
28Chronic myeloid leukemia_Homo sapiens_hsa052201.38223646
29Base excision repair_Homo sapiens_hsa034101.37397737
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37150264
31Influenza A_Homo sapiens_hsa051641.35103849
32Apoptosis_Homo sapiens_hsa042101.30555291
33Hepatitis B_Homo sapiens_hsa051611.28957945
34Rheumatoid arthritis_Homo sapiens_hsa053231.25773493
35TNF signaling pathway_Homo sapiens_hsa046681.24486922
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22603896
37Shigellosis_Homo sapiens_hsa051311.21225245
38Graft-versus-host disease_Homo sapiens_hsa053321.21142875
39Legionellosis_Homo sapiens_hsa051341.18833095
40Platelet activation_Homo sapiens_hsa046111.17305623
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17240605
42Tuberculosis_Homo sapiens_hsa051521.16211418
43Pertussis_Homo sapiens_hsa051331.10265313
44Epstein-Barr virus infection_Homo sapiens_hsa051691.09646886
45HTLV-I infection_Homo sapiens_hsa051661.04484680
46Small cell lung cancer_Homo sapiens_hsa052221.03095484
47Pancreatic cancer_Homo sapiens_hsa052121.00885369
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98128842
49Staphylococcus aureus infection_Homo sapiens_hsa051500.97302233
50Viral carcinogenesis_Homo sapiens_hsa052030.95916731
51Mismatch repair_Homo sapiens_hsa034300.94851859
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94494153
53Malaria_Homo sapiens_hsa051440.91263578
54Non-small cell lung cancer_Homo sapiens_hsa052230.88957678
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88290380
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.83346017
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80275407
58Phagosome_Homo sapiens_hsa041450.78735926
59Insulin resistance_Homo sapiens_hsa049310.78463289
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77571034
61Autoimmune thyroid disease_Homo sapiens_hsa053200.76037531
62Asthma_Homo sapiens_hsa053100.74466014
63FoxO signaling pathway_Homo sapiens_hsa040680.73508025
64Other glycan degradation_Homo sapiens_hsa005110.73466162
65Homologous recombination_Homo sapiens_hsa034400.70458755
66Salmonella infection_Homo sapiens_hsa051320.70406457
67Hepatitis C_Homo sapiens_hsa051600.69580595
68Colorectal cancer_Homo sapiens_hsa052100.68263688
69Notch signaling pathway_Homo sapiens_hsa043300.65737992
70Cell cycle_Homo sapiens_hsa041100.65319135
71p53 signaling pathway_Homo sapiens_hsa041150.64923329
72Ribosome_Homo sapiens_hsa030100.63767267
73VEGF signaling pathway_Homo sapiens_hsa043700.63435750
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62619114
75HIF-1 signaling pathway_Homo sapiens_hsa040660.61995290
76Prolactin signaling pathway_Homo sapiens_hsa049170.61513479
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61161390
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61105793
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59036374
80Systemic lupus erythematosus_Homo sapiens_hsa053220.58563359
81MicroRNAs in cancer_Homo sapiens_hsa052060.58443112
82Spliceosome_Homo sapiens_hsa030400.58296973
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54496702
84Lysine degradation_Homo sapiens_hsa003100.54230911
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51195392
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47381350
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.47197150
88Dorso-ventral axis formation_Homo sapiens_hsa043200.45974963
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.45883283
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45152123
91Fanconi anemia pathway_Homo sapiens_hsa034600.44748565
92Dilated cardiomyopathy_Homo sapiens_hsa054140.44706638
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44203494
94African trypanosomiasis_Homo sapiens_hsa051430.42285960
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41864029
96Prostate cancer_Homo sapiens_hsa052150.41832723
97Lysosome_Homo sapiens_hsa041420.41662208
98Pathways in cancer_Homo sapiens_hsa052000.41448581
99MAPK signaling pathway_Homo sapiens_hsa040100.41036835
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40396649
101Renal cell carcinoma_Homo sapiens_hsa052110.39565889
102Inositol phosphate metabolism_Homo sapiens_hsa005620.37443949
103Focal adhesion_Homo sapiens_hsa045100.36314708
104mTOR signaling pathway_Homo sapiens_hsa041500.35933616
105RNA degradation_Homo sapiens_hsa030180.35456404
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.34558189
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.34054883
108Regulation of autophagy_Homo sapiens_hsa041400.30815510
109Type II diabetes mellitus_Homo sapiens_hsa049300.30349977
110Proteoglycans in cancer_Homo sapiens_hsa052050.30094908
111Nucleotide excision repair_Homo sapiens_hsa034200.29623436
112Endometrial cancer_Homo sapiens_hsa052130.29352047
113Choline metabolism in cancer_Homo sapiens_hsa052310.29044013
114Endocytosis_Homo sapiens_hsa041440.28394518
115Insulin signaling pathway_Homo sapiens_hsa049100.27225885
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.27005531
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26276490
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26224245
119GnRH signaling pathway_Homo sapiens_hsa049120.26146612
120Type I diabetes mellitus_Homo sapiens_hsa049400.25420124
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22249825
122Oxytocin signaling pathway_Homo sapiens_hsa049210.20335073
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13486961
124Amoebiasis_Homo sapiens_hsa051460.12951331
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10480196

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