RCVRN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GMP metabolic process (GO:0046037)9.91681587
2retinal rod cell development (GO:0046548)9.06710796
3* visual perception (GO:0007601)8.77173639
4* sensory perception of light stimulus (GO:0050953)8.66959748
5* positive regulation of guanylate cyclase activity (GO:0031284)7.56483534
6* cellular response to light stimulus (GO:0071482)7.30347155
7photoreceptor cell differentiation (GO:0046530)7.19466147
8eye photoreceptor cell differentiation (GO:0001754)7.19466147
9* detection of external stimulus (GO:0009581)7.16959664
10* detection of abiotic stimulus (GO:0009582)7.02801279
11* regulation of guanylate cyclase activity (GO:0031282)6.75531588
12retina development in camera-type eye (GO:0060041)6.54245156
13detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)6.46144573
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.68122701
15positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.36572504
16* regulation of cGMP metabolic process (GO:0030823)5.30370413
17receptor guanylyl cyclase signaling pathway (GO:0007168)5.27627362
18cell morphogenesis involved in neuron differentiation (GO:0048667)5.08171930
19negative regulation of cardiac muscle hypertrophy (GO:0010614)4.95687962
20nonmotile primary cilium assembly (GO:0035058)4.82567884
21* cellular response to radiation (GO:0071478)4.68583225
22adaptation of signaling pathway (GO:0023058)4.59012515
23regulation of voltage-gated calcium channel activity (GO:1901385)4.45846445
24negative regulation of muscle hypertrophy (GO:0014741)4.40557156
25* regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.27812377
26* positive regulation of cGMP biosynthetic process (GO:0030828)4.24151253
27response to electrical stimulus (GO:0051602)4.23235959
28transepithelial transport (GO:0070633)4.12604129
29protein prenylation (GO:0018342)4.11107698
30prenylation (GO:0097354)4.11107698
31* sensory perception (GO:0007600)4.10521019
32short-term memory (GO:0007614)4.09311352
33fat-soluble vitamin metabolic process (GO:0006775)4.00224066
34sensory perception of taste (GO:0050909)3.96728196
35* regulation of cGMP biosynthetic process (GO:0030826)3.96081420
36regulation of clathrin-mediated endocytosis (GO:2000369)3.92686435
37* response to light stimulus (GO:0009416)3.92387928
38positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.88785015
39regulation of penile erection (GO:0060405)3.88084657
40estrogen biosynthetic process (GO:0006703)3.82333548
41behavioral response to ethanol (GO:0048149)3.81505922
42regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.81323766
43regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.81323766
44negative regulation of heart growth (GO:0061117)3.79796049
45negative regulation of cardiac muscle tissue growth (GO:0055022)3.79796049
46chemosensory behavior (GO:0007635)3.78355028
47neuron development (GO:0048666)3.72963326
48retina homeostasis (GO:0001895)3.72756317
49cellular response to ATP (GO:0071318)3.70641419
50* positive regulation of cGMP metabolic process (GO:0030825)3.69060976
51detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.68572104
52retinal metabolic process (GO:0042574)3.68167279
53response to histamine (GO:0034776)3.62958603
54retina layer formation (GO:0010842)3.50469871
55positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.48265992
56keratan sulfate catabolic process (GO:0042340)3.45778462
57positive regulation of sodium ion transmembrane transport (GO:1902307)3.40129648
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.39360548
59detection of chemical stimulus involved in sensory perception (GO:0050907)3.36918054
60regulation of skeletal muscle contraction (GO:0014819)3.32618951
61positive regulation of neurotransmitter transport (GO:0051590)3.31650236
62positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.31472326
63negative regulation of receptor-mediated endocytosis (GO:0048261)3.31285192
64purinergic nucleotide receptor signaling pathway (GO:0035590)3.26556676
65acrosome reaction (GO:0007340)3.23967187
66CDP-diacylglycerol biosynthetic process (GO:0016024)3.19097382
67membrane hyperpolarization (GO:0060081)3.18690056
68protein localization to synapse (GO:0035418)3.17625704
69regulation of cytokine production involved in inflammatory response (GO:1900015)3.13722524
70retinoid metabolic process (GO:0001523)3.13049366
71positive regulation of ERBB signaling pathway (GO:1901186)3.09825317
72positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.06486666
73regulation of heat generation (GO:0031650)3.04828829
74regulation of short-term neuronal synaptic plasticity (GO:0048172)3.03811788
75positive regulation of heat generation (GO:0031652)3.00724875
76arachidonic acid secretion (GO:0050482)2.97118926
77icosanoid secretion (GO:0032309)2.97118926
78CDP-diacylglycerol metabolic process (GO:0046341)2.96387185
79phosphatidylinositol acyl-chain remodeling (GO:0036149)2.95193643
80behavioral response to cocaine (GO:0048148)2.94686413
81diterpenoid metabolic process (GO:0016101)2.89747182
82negative regulation of cation channel activity (GO:2001258)2.88335565
83synaptic transmission, dopaminergic (GO:0001963)2.86113127
84negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.85197910
85negative regulation of calcium ion transmembrane transport (GO:1903170)2.85197910
86negative regulation of cardiac muscle tissue development (GO:0055026)2.82216058
87piRNA metabolic process (GO:0034587)2.75576442
88phospholipid translocation (GO:0045332)2.73802987
89lipid translocation (GO:0034204)2.73802987
90* response to radiation (GO:0009314)2.70364936
91dopamine receptor signaling pathway (GO:0007212)2.68546172
92retinol metabolic process (GO:0042572)2.68203544
93neutrophil activation involved in immune response (GO:0002283)2.67605002
94purinergic receptor signaling pathway (GO:0035587)2.67341879
95negative regulation of transcription regulatory region DNA binding (GO:2000678)2.66561477
96indole-containing compound catabolic process (GO:0042436)2.66332771
97indolalkylamine catabolic process (GO:0046218)2.66332771
98tryptophan catabolic process (GO:0006569)2.66332771
99terpenoid metabolic process (GO:0006721)2.65327908
100peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.65213287
101regulation of neurotransmitter uptake (GO:0051580)2.62984052
102protein heterotetramerization (GO:0051290)2.58717416
103regulation of catecholamine metabolic process (GO:0042069)2.57359175
104regulation of dopamine metabolic process (GO:0042053)2.57359175
105synaptic vesicle maturation (GO:0016188)2.55673988
106behavioral response to nicotine (GO:0035095)2.49653739
107post-embryonic morphogenesis (GO:0009886)2.46304361
108mitotic cell cycle arrest (GO:0071850)2.42738914
109G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.42438342
110response to hydroperoxide (GO:0033194)2.42007858
111lipoprotein transport (GO:0042953)2.41285790
112cell wall macromolecule catabolic process (GO:0016998)2.40353860
113cilium or flagellum-dependent cell motility (GO:0001539)2.40274393
114fatty acid derivative transport (GO:1901571)2.38548204
115icosanoid transport (GO:0071715)2.38548204
116axoneme assembly (GO:0035082)2.37819194
117indolalkylamine metabolic process (GO:0006586)2.37166845
118positive regulation of membrane potential (GO:0045838)2.36661076
119sensory perception of chemical stimulus (GO:0007606)2.36544051
120regulation of cardiac muscle hypertrophy (GO:0010611)2.36209676
121* cellular response to abiotic stimulus (GO:0071214)2.35743325
122positive regulation of vasculogenesis (GO:2001214)2.35564245
123DNA methylation involved in gamete generation (GO:0043046)2.33365595
124adenosine receptor signaling pathway (GO:0001973)2.31343938
125mature B cell differentiation involved in immune response (GO:0002313)2.31120236
126lens fiber cell differentiation (GO:0070306)2.29798639
127negative regulation of mast cell activation (GO:0033004)2.27436820
128regulation of muscle hypertrophy (GO:0014743)2.25401166
129sialylation (GO:0097503)2.25023000
130phosphatidylethanolamine biosynthetic process (GO:0006646)2.23517085
131response to ATP (GO:0033198)2.22760198
132regulation of cardiac muscle cell differentiation (GO:2000725)2.22191431
133negative regulation of cell aging (GO:0090344)2.19847905
134auditory receptor cell stereocilium organization (GO:0060088)2.14996654
135response to peptidoglycan (GO:0032494)2.14881847
136inositol phosphate catabolic process (GO:0071545)2.12979585
137phosphatidylserine acyl-chain remodeling (GO:0036150)2.11748946
138tryptophan metabolic process (GO:0006568)2.11311258
139protein K11-linked deubiquitination (GO:0035871)2.10116044
140fusion of sperm to egg plasma membrane (GO:0007342)2.08773057
141phosphatidylethanolamine metabolic process (GO:0046337)2.08452227
142sperm motility (GO:0030317)2.06478974
143negative regulation of organ growth (GO:0046621)2.06234637
144response to xenobiotic stimulus (GO:0009410)2.04912942
145amino sugar catabolic process (GO:0046348)2.04334410
146phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.02093593
147negative regulation of interleukin-8 production (GO:0032717)2.01241738
148amine catabolic process (GO:0009310)2.00566902
149* regulation of rhodopsin mediated signaling pathway (GO:0022400)18.2849468
150* rhodopsin mediated signaling pathway (GO:0016056)17.7826666
151retinal cone cell development (GO:0046549)17.3538273
152vitamin A metabolic process (GO:0006776)15.3477525
153photoreceptor cell development (GO:0042461)12.6966214
154eye photoreceptor cell development (GO:0042462)12.2151649
155photoreceptor cell maintenance (GO:0045494)11.7702497
156detection of light stimulus involved in sensory perception (GO:0050962)11.6088914
157detection of light stimulus involved in visual perception (GO:0050908)11.6088914
158* phototransduction (GO:0007602)10.8781771
159cellular response to electrical stimulus (GO:0071257)10.8455735
160* phototransduction, visible light (GO:0007603)10.6220248
161* detection of light stimulus (GO:0009583)10.2903959
162protein-chromophore linkage (GO:0018298)10.1895828
163* detection of visible light (GO:0009584)10.1759503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.21100583
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.44845654
3VDR_22108803_ChIP-Seq_LS180_Human4.18872727
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.40194791
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.29204645
6DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.53041603
7GBX2_23144817_ChIP-Seq_PC3_Human2.50861706
8DROSHA_22980978_ChIP-Seq_HELA_Human2.38557364
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.15900272
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08963371
11BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.04134864
12GATA1_26923725_Chip-Seq_HPCs_Mouse1.92008470
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87848170
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83804033
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82331440
16SMAD3_21741376_ChIP-Seq_HESCs_Human1.81870768
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79744374
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78228524
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.69476606
20AR_21572438_ChIP-Seq_LNCaP_Human1.68420510
21KDM2B_26808549_Chip-Seq_K562_Human1.67834455
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66057028
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.66020783
24SCL_19346495_ChIP-Seq_HPC-7_Human1.63733984
25VDR_24787735_ChIP-Seq_THP-1_Human1.62341909
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.61965174
27TAF15_26573619_Chip-Seq_HEK293_Human1.60933290
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.60188715
29REST_21632747_ChIP-Seq_MESCs_Mouse1.59278236
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.56698747
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56314812
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.55349476
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54568013
34AR_19668381_ChIP-Seq_PC3_Human1.53746657
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52716709
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.52437316
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51517645
38EZH2_22144423_ChIP-Seq_EOC_Human1.50295281
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48524915
40IGF1R_20145208_ChIP-Seq_DFB_Human1.47294465
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.44443649
42ZNF274_21170338_ChIP-Seq_K562_Hela1.43575831
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43081292
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41575608
45P53_22127205_ChIP-Seq_FIBROBLAST_Human1.41012158
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39840708
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39361063
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37686350
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.37474587
50TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.37419825
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37191838
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36239576
53NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.35883669
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35410149
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.34904949
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34468423
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34420976
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32268075
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31799582
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29167365
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27945293
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27945293
63BCAT_22108803_ChIP-Seq_LS180_Human1.27251928
64TBL1_22424771_ChIP-Seq_293T_Human1.23707572
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22953381
66SMAD4_21799915_ChIP-Seq_A2780_Human1.21152389
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.18649795
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17748856
69MYC_19829295_ChIP-Seq_ESCs_Human1.17662714
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16839438
71* SMC4_20622854_ChIP-Seq_HELA_Human1.16448330
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.16445339
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16109616
74CREB1_26743006_Chip-Seq_LNCaP_Human1.15286904
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15056669
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14669965
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14669965
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13970651
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13925291
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13364682
81EWS_26573619_Chip-Seq_HEK293_Human1.13069442
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.12398203
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.12046268
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11686569
85NCOR_22424771_ChIP-Seq_293T_Human1.11497818
86WDR5_24793694_ChIP-Seq_LNCAP_Human1.11430432
87TAF2_19829295_ChIP-Seq_ESCs_Human1.11358853
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11135722
89ER_23166858_ChIP-Seq_MCF-7_Human1.09362204
90* CTCF_27219007_Chip-Seq_Bcells_Human1.08335640
91AR_25329375_ChIP-Seq_VCAP_Human1.07525428
92FUS_26573619_Chip-Seq_HEK293_Human1.07264298
93RXR_22108803_ChIP-Seq_LS180_Human1.07169763
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05838724
95OCT4_20526341_ChIP-Seq_ESCs_Human1.05632840
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05577049
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05432650
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05432650
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05235605
100STAT3_23295773_ChIP-Seq_U87_Human1.05120811
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04728136
102CTCF_20526341_ChIP-Seq_ESCs_Human1.04627035
103CBP_21632823_ChIP-Seq_H3396_Human1.04568509
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03945646
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03834706
106EGR1_19032775_ChIP-ChIP_M12_Human1.02854064
107KDM2B_26808549_Chip-Seq_JURKAT_Human1.02198212
108VDR_24763502_ChIP-Seq_THP-1_Human1.02073264
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01154722
110ISL1_27105846_Chip-Seq_CPCs_Mouse0.99145732
111ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98567880
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98446443
113P68_20966046_ChIP-Seq_HELA_Human0.97846015
114OCT1_27270436_Chip-Seq_PROSTATE_Human0.97475345
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97164159
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96497154
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.96349387
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96007124
119DPY_21335234_ChIP-Seq_ESCs_Mouse0.95856833
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95418164
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.95006025
122OCT4_19829295_ChIP-Seq_ESCs_Human0.94960332
123TCF4_22108803_ChIP-Seq_LS180_Human0.94580994
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94286937
125BCL6_27268052_Chip-Seq_Bcells_Human0.93982092
126P300_19829295_ChIP-Seq_ESCs_Human0.93866464
127IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93691857
128JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93521695
129CJUN_26792858_Chip-Seq_BT549_Human0.93364604
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93161087
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93041217
132KDM2B_26808549_Chip-Seq_REH_Human0.92680350
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92300913
134PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91811549
135SMAD4_21741376_ChIP-Seq_EPCs_Human0.91636370
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.91593439
137YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91259290
138SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91122522
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90917663
140GF1_26923725_Chip-Seq_HPCs_Mouse0.90375011
141FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90331581
142CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90053391
143ERG_20517297_ChIP-Seq_VCAP_Human0.89837152
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.89634987
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88879755
146CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88673254
147* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.88521308
148NANOG_19829295_ChIP-Seq_ESCs_Human0.88205159
149SOX2_19829295_ChIP-Seq_ESCs_Human0.88205159
150* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87341244
151CBP_20019798_ChIP-Seq_JUKART_Human0.86719403
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86719403
153OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86474360
154ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86425272
155GATA2_21666600_ChIP-Seq_HMVEC_Human0.86250912
156PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85856069
157RING1B_27294783_Chip-Seq_ESCs_Mouse0.84616466
158SMAD4_21741376_ChIP-Seq_ESCs_Human0.84472756
159RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84416535
160NANOG_20526341_ChIP-Seq_ESCs_Human0.83538118
161TCF4_23295773_ChIP-Seq_U87_Human0.81759542
162TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81110901
163EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.80728470
164BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80341927
165LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80144835

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.76772848
2* MP0005253_abnormal_eye_physiology6.61396902
3MP0006072_abnormal_retinal_apoptosis6.58559264
4MP0003950_abnormal_plasma_membrane4.02327192
5MP0005195_abnormal_posterior_eye3.90817225
6MP0001324_abnormal_eye_pigmentation3.45043396
7* MP0005391_vision/eye_phenotype3.16707385
8MP0002090_abnormal_vision3.01677967
9MP0005423_abnormal_somatic_nervous2.91978401
10MP0002638_abnormal_pupillary_reflex2.80577002
11MP0002229_neurodegeneration2.59019429
12MP0001986_abnormal_taste_sensitivity2.56902374
13MP0005171_absent_coat_pigmentation2.19342799
14MP0001764_abnormal_homeostasis2.14726328
15MP0003011_delayed_dark_adaptation11.2153233
16MP0003136_yellow_coat_color1.97507070
17MP0002752_abnormal_somatic_nervous1.93314341
18MP0004019_abnormal_vitamin_homeostasis1.40101027
19MP0002882_abnormal_neuron_morphology1.38692767
20MP0002653_abnormal_ependyma_morphology1.34140531
21MP0005174_abnormal_tail_pigmentation1.23455130
22MP0005167_abnormal_blood-brain_barrier1.23251545
23MP0004233_abnormal_muscle_weight1.11789678
24MP0001984_abnormal_olfaction1.06140649
25MP0005410_abnormal_fertilization1.04481434
26MP0003724_increased_susceptibility_to1.02598260
27MP0005197_abnormal_uvea_morphology1.01963827
28MP0001502_abnormal_circadian_rhythm0.93784699
29MP0004885_abnormal_endolymph0.93015380
30MP0002736_abnormal_nociception_after0.92046662
31MP0003303_peritoneal_inflammation0.89470685
32MP0002127_abnormal_cardiovascular_syste0.88541682
33MP0002332_abnormal_exercise_endurance0.88489587
34MP0004270_analgesia0.85650089
35MP0009764_decreased_sensitivity_to0.84727513
36MP0002254_reproductive_system_inflammat0.78542131
37MP0005499_abnormal_olfactory_system0.78488994
38MP0005394_taste/olfaction_phenotype0.78488994
39MP0001486_abnormal_startle_reflex0.78200553
40MP0000569_abnormal_digit_pigmentation0.77690610
41MP0003634_abnormal_glial_cell0.77487780
42MP0002272_abnormal_nervous_system0.76488284
43MP0005187_abnormal_penis_morphology0.74973692
44MP0002102_abnormal_ear_morphology0.74634756
45MP0006054_spinal_hemorrhage0.73870216
46MP0006082_CNS_inflammation0.73691952
47MP0003172_abnormal_lysosome_physiology0.68791795
48MP0004381_abnormal_hair_follicle0.68467095
49MP0008789_abnormal_olfactory_epithelium0.64226993
50MP0001545_abnormal_hematopoietic_system0.61761514
51MP0005397_hematopoietic_system_phenotyp0.61761514
52MP0005058_abnormal_lysosome_morphology0.61351992
53MP0000516_abnormal_urinary_system0.60883358
54MP0005367_renal/urinary_system_phenotyp0.60883358
55MP0006292_abnormal_olfactory_placode0.60111156
56MP0002735_abnormal_chemical_nociception0.60050796
57MP0003075_altered_response_to0.57179710
58MP0003880_abnormal_central_pattern0.56706737
59MP0004859_abnormal_synaptic_plasticity0.55761679
60MP0002734_abnormal_mechanical_nocicepti0.55515577
61MP0000538_abnormal_urinary_bladder0.52511231
62MP0002148_abnormal_hypersensitivity_rea0.52479697
63MP0002064_seizures0.51995660
64MP0005376_homeostasis/metabolism_phenot0.49143935
65MP0001286_abnormal_eye_development0.48940175
66MP0001756_abnormal_urination0.48768611
67MP0005451_abnormal_body_composition0.47752806
68MP0000465_gastrointestinal_hemorrhage0.47693076
69MP0003635_abnormal_synaptic_transmissio0.47682938
70MP0001963_abnormal_hearing_physiology0.46379840
71MP0003878_abnormal_ear_physiology0.46376605
72MP0005377_hearing/vestibular/ear_phenot0.46376605
73MP0009046_muscle_twitch0.46084341
74MP0008004_abnormal_stomach_pH0.44746290
75MP0003045_fibrosis0.43843958
76MP0002837_dystrophic_cardiac_calcinosis0.43064500
77MP0002419_abnormal_innate_immunity0.42574340
78MP0000015_abnormal_ear_pigmentation0.41368600
79MP0002933_joint_inflammation0.41296566
80MP0001835_abnormal_antigen_presentation0.41202266
81MP0002063_abnormal_learning/memory/cond0.39792176
82MP0002572_abnormal_emotion/affect_behav0.39576624
83MP0004145_abnormal_muscle_electrophysio0.38890883
84MP0002067_abnormal_sensory_capabilities0.38195594
85MP0004215_abnormal_myocardial_fiber0.37300428
86MP0009745_abnormal_behavioral_response0.36448666
87MP0003436_decreased_susceptibility_to0.36031511
88MP0001968_abnormal_touch/_nociception0.35838054
89MP0000343_altered_response_to0.35277442
90MP0004924_abnormal_behavior0.34272829
91MP0005386_behavior/neurological_phenoty0.34272829
92MP0005000_abnormal_immune_tolerance0.34196897
93MP0008877_abnormal_DNA_methylation0.34181189
94MP0005620_abnormal_muscle_contractility0.33550866
95MP0004484_altered_response_of0.32745738
96MP0004085_abnormal_heartbeat0.32620331
97MP0004782_abnormal_surfactant_physiolog0.32214842
98MP0008775_abnormal_heart_ventricle0.31955440
99MP0003300_gastrointestinal_ulcer0.31782502
100MP0005670_abnormal_white_adipose0.31693231
101MP0000372_irregular_coat_pigmentation0.30132960
102MP0001800_abnormal_humoral_immune0.30039971
103MP0002452_abnormal_antigen_presenting0.29470964
104MP0002282_abnormal_trachea_morphology0.29397517
105MP0001905_abnormal_dopamine_level0.29298180
106MP0002733_abnormal_thermal_nociception0.29188043
107MP0005595_abnormal_vascular_smooth0.29058273
108MP0004142_abnormal_muscle_tone0.28568599
109MP0001879_abnormal_lymphatic_vessel0.28389596
110MP0005671_abnormal_response_to0.28381483
111MP0000685_abnormal_immune_system0.27896145
112MP0002075_abnormal_coat/hair_pigmentati0.27889901
113MP0005365_abnormal_bile_salt0.27432950
114MP0005535_abnormal_body_temperature0.27160700
115MP0001790_abnormal_immune_system0.26742032
116MP0005387_immune_system_phenotype0.26742032
117MP0001661_extended_life_span0.26451024
118MP0002723_abnormal_immune_serum0.25972003
119MP0005076_abnormal_cell_differentiation0.25546251
120MP0004043_abnormal_pH_regulation0.25540730
121MP0003698_abnormal_male_reproductive0.25301144
122MP0000631_abnormal_neuroendocrine_gland0.25222843
123MP0005310_abnormal_salivary_gland0.24927710
124MP0003646_muscle_fatigue0.24229437
125MP0001533_abnormal_skeleton_physiology0.24018054
126MP0004742_abnormal_vestibular_system0.23606213
127MP0003252_abnormal_bile_duct0.22838767
128MP0000026_abnormal_inner_ear0.22760320
129MP0003638_abnormal_response/metabolism_0.22465043
130MP0005165_increased_susceptibility_to0.22450218
131MP0008569_lethality_at_weaning0.22232691
132MP0003787_abnormal_imprinting0.21296790
133MP0000751_myopathy0.21160277
134MP0002108_abnormal_muscle_morphology0.19907752
135MP0009780_abnormal_chondrocyte_physiolo0.19849186
136MP0002066_abnormal_motor_capabilities/c0.19630901
137MP0002152_abnormal_brain_morphology0.18961414
138MP0010386_abnormal_urinary_bladder0.18432098
139MP0004811_abnormal_neuron_physiology0.18175682
140MP0002928_abnormal_bile_duct0.17561277
141MP0005193_abnormal_anterior_eye0.17461126
142MP0001915_intracranial_hemorrhage0.17318973
143MP0005330_cardiomyopathy0.15624692
144MP0003632_abnormal_nervous_system0.12857260
145MP0005248_abnormal_Harderian_gland0.12791197
146MP0002184_abnormal_innervation0.12126026
147MP0003943_abnormal_hepatobiliary_system0.11337238
148MP0002697_abnormal_eye_size0.11161085
149MP0003890_abnormal_embryonic-extraembry0.11056234
150MP0000230_abnormal_systemic_arterial0.10706098
151MP0003633_abnormal_nervous_system0.10467709
152MP0000749_muscle_degeneration0.10435180
153MP0005084_abnormal_gallbladder_morpholo0.10391314
154MP0005646_abnormal_pituitary_gland0.10278178
155MP0001614_abnormal_blood_vessel0.09595718
156MP0001501_abnormal_sleep_pattern0.09435871
157MP0002557_abnormal_social/conspecific_i0.08639193
158MP0001970_abnormal_pain_threshold0.08413539
159MP0008875_abnormal_xenobiotic_pharmacok0.08319125
160MP0005266_abnormal_metabolism0.08138156
161MP0002909_abnormal_adrenal_gland0.07792344

Predicted human phenotypes

RankGene SetZ-score
1Dyschromatopsia (HP:0007641)9.66382462
2Pigmentary retinal degeneration (HP:0001146)9.61272556
3Chorioretinal atrophy (HP:0000533)8.31168822
4Central scotoma (HP:0000603)8.00525495
5Abnormality of macular pigmentation (HP:0008002)7.87844493
6Attenuation of retinal blood vessels (HP:0007843)7.74644149
7Pendular nystagmus (HP:0012043)7.52925386
8Scotoma (HP:0000575)7.19762865
9Decreased central vision (HP:0007663)6.49034051
10Abolished electroretinogram (ERG) (HP:0000550)6.41940138
11Photophobia (HP:0000613)5.84480822
12Type II diabetes mellitus (HP:0005978)5.72572915
13Vitreoretinal degeneration (HP:0000655)5.45137627
14Macular degeneration (HP:0000608)5.17041031
15Increased corneal curvature (HP:0100692)4.70214778
16Keratoconus (HP:0000563)4.70214778
17Choroideremia (HP:0001139)4.67402543
18Severe visual impairment (HP:0001141)4.47826804
19Retinitis pigmentosa (HP:0000510)4.45486269
20Cone-rod dystrophy (HP:0000548)4.43647697
21Posterior subcapsular cataract (HP:0007787)4.42679674
22Constricted visual fields (HP:0001133)4.08738542
23Decreased electroretinogram (ERG) amplitude (HP:0000654)3.72649412
24Systemic lupus erythematosus (HP:0002725)3.24049036
25Progressive visual loss (HP:0000529)3.04760662
26Retinal atrophy (HP:0001105)2.95662610
27Optic disc pallor (HP:0000543)2.71810948
28Subcapsular cataract (HP:0000523)2.67332756
29Congenital sensorineural hearing impairment (HP:0008527)2.58333065
30Wide nasal bridge (HP:0000431)2.55853314
31Mesangial abnormality (HP:0001966)2.46658235
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.39315349
33Gait imbalance (HP:0002141)2.37861426
34Congenital primary aphakia (HP:0007707)2.35645501
35Glomerulonephritis (HP:0000099)2.30984597
36Mutism (HP:0002300)2.22480198
37Action tremor (HP:0002345)2.14827532
38Ulnar claw (HP:0001178)2.13676588
39Nephrogenic diabetes insipidus (HP:0009806)2.07679250
40Medial flaring of the eyebrow (HP:0010747)2.00527682
41Congenital stationary night blindness (HP:0007642)15.6958514
42Bony spicule pigmentary retinopathy (HP:0007737)11.7335976
43Absent rod-and cone-mediated responses on ERG (HP:0007688)10.6148508
44Abnormal rod and cone electroretinograms (HP:0008323)10.1693641
45Complement deficiency (HP:0004431)1.99810584
46Thyroiditis (HP:0100646)1.98844206
47Poor coordination (HP:0002370)1.79341392
48Akinesia (HP:0002304)1.77056146
49Disinhibition (HP:0000734)1.75144027
50Increased cerebral lipofuscin (HP:0011813)1.75025345
51Hemorrhage of the eye (HP:0011885)1.72152450
52Hyperventilation (HP:0002883)1.69723765
53Optic atrophy (HP:0000648)1.63654065
54Increased neuronal autofluorescent lipopigment (HP:0002074)1.63073777
55Interstitial pulmonary disease (HP:0006530)1.62520919
56Vaginal atresia (HP:0000148)1.62150822
57Absent speech (HP:0001344)1.61084428
58Peripheral hypomyelination (HP:0007182)1.60284797
59Horizontal nystagmus (HP:0000666)1.56178115
60Abnormality of the costochondral junction (HP:0000919)1.55603069
61Amyloidosis (HP:0011034)1.55183753
62Genital tract atresia (HP:0001827)1.55021403
63Hematochezia (HP:0002573)1.54917781
64Abnormality of glycolipid metabolism (HP:0010969)1.53331789
65Abnormality of liposaccharide metabolism (HP:0010968)1.53331789
66Abnormality of glycosphingolipid metabolism (HP:0004343)1.53331789
67Nephritis (HP:0000123)1.52734713
68Fetal akinesia sequence (HP:0001989)1.51937663
69Annular pancreas (HP:0001734)1.51915886
70Abnormal albumin level (HP:0012116)1.50943926
71Hypoalbuminemia (HP:0003073)1.50943926
72Enlarged epiphyses (HP:0010580)1.46041007
73Abnormal drinking behavior (HP:0030082)1.45726714
74Polydipsia (HP:0001959)1.45726714
75Polar cataract (HP:0010696)1.45106912
76Vacuolated lymphocytes (HP:0001922)1.43947011
77Metaphyseal irregularity (HP:0003025)1.39216597
78True hermaphroditism (HP:0010459)1.38888726
79Long clavicles (HP:0000890)1.37384483
80Agnosia (HP:0010524)1.37323645
81Zonular cataract (HP:0010920)1.36567674
82Abnormality of complement system (HP:0005339)1.35849071
83Severe Myopia (HP:0011003)1.35579043
84Coronal craniosynostosis (HP:0004440)1.35323100
85Tubular atrophy (HP:0000092)1.34520561
86Abnormal pupillary function (HP:0007686)1.33259042
87Dysostosis multiplex (HP:0000943)1.32414237
88White forelock (HP:0002211)1.32341615
89Dysdiadochokinesis (HP:0002075)1.31602723
90Increased CSF protein (HP:0002922)1.30984699
91Aplasia/Hypoplasia of the lens (HP:0008063)1.30881898
92Abnormality of mucopolysaccharide metabolism (HP:0011020)1.25482397
93Abnormality of polysaccharide metabolism (HP:0011012)1.25482397
94Abnormality of glycosaminoglycan metabolism (HP:0004371)1.25482397
95Abnormality of the vasculature of the conjunctiva (HP:0008054)1.25139440
96Axonal loss (HP:0003447)1.24972383
97Joint hemorrhage (HP:0005261)1.24761315
98Abnormality of the hepatic vasculature (HP:0006707)1.23860310
99Hypoplastic pelvis (HP:0008839)1.23329937
100Delayed epiphyseal ossification (HP:0002663)1.22892319
101Albinism (HP:0001022)1.22757182
102Rib fusion (HP:0000902)1.20720026
103Hypopigmentation of the fundus (HP:0007894)1.20703681
104Facial diplegia (HP:0001349)1.19739196
105Poor head control (HP:0002421)1.19349310
106Retinal detachment (HP:0000541)1.19319267
107Stomatitis (HP:0010280)1.18510683
108Hypoplastic iliac wings (HP:0002866)1.16669521
109Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.16434318
110Widely patent fontanelles and sutures (HP:0004492)1.15505830
111Dyskinesia (HP:0100660)1.13670794
112Recurrent abscess formation (HP:0002722)1.13427696
113Epileptic encephalopathy (HP:0200134)1.11180760
114Pancreatic fibrosis (HP:0100732)1.08615320
115Astigmatism (HP:0000483)1.03748322
116Abnormality of the fovea (HP:0000493)1.03191154
117Broad foot (HP:0001769)0.99482165
118Cerebellar dysplasia (HP:0007033)0.99296448
119Left ventricular hypertrophy (HP:0001712)0.98729332
120Hypoplasia of the fovea (HP:0007750)0.97773719
121Aplasia/Hypoplasia of the fovea (HP:0008060)0.97773719
122Recurrent sinusitis (HP:0011108)0.97722167
123Specific learning disability (HP:0001328)0.96642548
124Truncal ataxia (HP:0002078)0.95074942
125Febrile seizures (HP:0002373)0.94666935
126Decreased testicular size (HP:0008734)0.92082471
127Cystic liver disease (HP:0006706)0.91478956
128Progressive cerebellar ataxia (HP:0002073)0.88982882
129Asthma (HP:0002099)0.87807608
130Pancreatic cysts (HP:0001737)0.84933576
131Chorioretinal coloboma (HP:0000567)0.83128494
132Visual hallucinations (HP:0002367)0.82557503
133Hypermetropia (HP:0000540)0.77935569
134Aplasia/Hypoplasia of the macula (HP:0008059)0.76870334
135Aplasia/Hypoplasia of the tongue (HP:0010295)0.76224652
136Partial agenesis of the corpus callosum (HP:0001338)0.74642569
137Abnormality of dental color (HP:0011073)0.73946138
138Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.73911156
139Aplasia/Hypoplasia affecting the retina (HP:0008061)0.70640795
140Sclerocornea (HP:0000647)0.70593883
141Prolonged QT interval (HP:0001657)0.68794655
142Abnormality of midbrain morphology (HP:0002418)0.66178060
143Molar tooth sign on MRI (HP:0002419)0.66178060
144Dental crowding (HP:0000678)0.65537331
145Lymphopenia (HP:0001888)0.65364170
146Genetic anticipation (HP:0003743)0.64835690
147Furrowed tongue (HP:0000221)0.64330467
148Hypodontia (HP:0000668)0.63080446
149Short foot (HP:0001773)0.62884248
150Postaxial hand polydactyly (HP:0001162)0.60433693
151Aqueductal stenosis (HP:0002410)0.59596473
152Chronic hepatic failure (HP:0100626)0.59308568
153Broad-based gait (HP:0002136)0.58628503
154Abnormality of cells of the lymphoid lineage (HP:0012140)0.58527589
155Hypoventilation (HP:0002791)0.56852559
156Heterotopia (HP:0002282)0.56417786
157Polycystic ovaries (HP:0000147)0.56387295
158Macroorchidism (HP:0000053)0.55434773
159Generalized myoclonic seizures (HP:0002123)0.55073759
160Abnormal EKG (HP:0003115)0.54958620
161Nephrotic syndrome (HP:0000100)0.54298307
162Hirsutism (HP:0001007)0.53959002
163Abnormality of the parathyroid morphology (HP:0011766)0.53657318

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK7.66815169
2ACVR1B3.15498599
3PINK12.74426291
4WNK32.48918339
5BLK2.27856970
6IRAK22.19430287
7MAPK152.10659380
8GRK111.2493832
9INSRR1.85391398
10CCNB11.78155967
11ADRBK21.77765743
12ADRBK11.74912627
13STK38L1.73174921
14TGFBR21.69149122
15MAPK71.59477589
16TGFBR11.47825917
17CAMK1G1.47217219
18TAOK31.44968960
19SIK21.44968189
20RPS6KA41.40679841
21MAP4K21.40307331
22MUSK1.39101888
23NUAK11.37985502
24PIK3CG1.36795612
25ICK1.34725731
26CAMK1D1.27270577
27MAPK121.26016308
28CAMKK21.25039198
29BMPR1B1.24761626
30STK381.21350009
31CDK121.19947966
32MARK31.19887935
33STK391.12873007
34BRD41.11066932
35MAP3K101.10944507
36HIPK21.10779486
37MARK11.10145755
38IKBKB1.07721300
39PRKCZ1.07153137
40PAK61.04652912
41SGK2231.04353251
42SGK4941.04353251
43CSNK1D1.02673074
44NEK10.99760391
45PTK2B0.99187461
46MAP3K40.98626040
47GRK70.97442054
48PNCK0.96264120
49TNK20.94943819
50TNIK0.91606131
51OXSR10.90480017
52CSK0.90443222
53TRPM70.89214581
54PRKD30.86856986
55PRKCH0.85985602
56TXK0.84570328
57NLK0.84207991
58OBSCN0.82830024
59MYLK0.82496606
60CDK30.82082324
61TTK0.79526583
62ZAK0.79094726
63PHKG20.77705236
64PHKG10.77705236
65ERBB20.75647970
66CAMKK10.75398553
67SYK0.74768642
68SGK20.74215850
69MAP2K30.72858942
70FGFR20.72823484
71WNK10.71723103
72EIF2AK30.70231415
73NEK20.69717419
74AKT30.67823571
75SGK30.66205006
76PRKACG0.65783941
77PRKCB0.64694160
78BMPR20.64493855
79PRKAA10.64200820
80DDR20.64135195
81TEC0.62919739
82CAMK2D0.62800434
83IRAK10.62317370
84GRK50.61630531
85DYRK1A0.60921035
86LYN0.60674914
87FES0.59256117
88DAPK20.57743022
89TRIM280.56767023
90MAPKAPK30.56683685
91LATS10.55995871
92RPS6KA30.55978231
93PIM20.54915756
94PRKAA20.53889429
95PRKCQ0.53756967
96MAPK130.53669164
97NEK60.51768579
98KIT0.51338287
99PLK40.50606881
100FER0.50573819
101PLK20.50308239
102STK30.49200015
103CSF1R0.48521219
104TTN0.48031688
105TIE10.47654812
106CAMK10.46582868
107AKT20.45144878
108BTK0.45056092
109RIPK40.44356035
110CAMK2A0.44105319
111PRKDC0.43099318
112ZAP700.42085220
113DYRK1B0.41851559
114MAP3K140.41626848
115SCYL20.41453498
116CDK50.41148309
117SGK10.41065404
118TBK10.40628505
119PRKD20.39163398
120CSNK1G10.38700541
121PRKCE0.38439545
122PRKCG0.38414046
123MAP3K30.38240233
124GSK3B0.37829519
125MAPK90.37512977
126ABL10.36974483
127IRAK40.36618007
128DYRK20.36286135
129PRKG10.35927800
130MAP2K70.35542738
131MAP3K70.34727490
132RPS6KA50.34604002
133STK110.34448174
134MAPK140.33935690
135NTRK30.33617103
136HCK0.33534585
137MATK0.33447479
138TYK20.33445045
139PDGFRB0.33344849
140CSNK1G20.33274587
141PRKACA0.33094278
142EPHB20.32772091
143MAPK100.32183145
144CHEK20.32106418
145PLK30.31687966
146MINK10.31660518
147ERN10.31577917
148CAMK40.31375431
149JAK10.30924523
150IKBKE0.30490993
151SIK30.30004548
152CDK90.29454231
153ROCK10.29387032
154CSNK1G30.29060254
155ABL20.28925219
156RPS6KB10.28203970
157PRKCA0.27688124
158MAP2K40.27279127
159CDK10.25316410
160SIK10.25162291
161FRK0.22206223
162CSNK1E0.20461026
163PDK20.19606662
164PKN10.19315739
165ALK0.19000327
166MAPK30.18254228
167RPS6KB20.18026928
168MAPK80.16064263
169WNK40.15705768
170SRC0.14758949
171YES10.14209871
172CHEK10.14111902
173CDC42BPA0.13733272
174CDK150.12606209

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.25007493
2* Phototransduction_Homo sapiens_hsa0474416.0325453
3Asthma_Homo sapiens_hsa053101.82154367
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75158838
5Ether lipid metabolism_Homo sapiens_hsa005651.73561338
6Lysosome_Homo sapiens_hsa041421.65816722
7Synaptic vesicle cycle_Homo sapiens_hsa047211.55131856
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.49315103
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.45365399
10Linoleic acid metabolism_Homo sapiens_hsa005911.44066353
11Sphingolipid metabolism_Homo sapiens_hsa006001.43916429
12Olfactory transduction_Homo sapiens_hsa047401.43487022
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36622018
14Other glycan degradation_Homo sapiens_hsa005111.31396177
15Osteoclast differentiation_Homo sapiens_hsa043801.26380609
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23289906
17Pertussis_Homo sapiens_hsa051331.19106235
18Rheumatoid arthritis_Homo sapiens_hsa053231.17055818
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16360888
20Allograft rejection_Homo sapiens_hsa053301.15385550
21GABAergic synapse_Homo sapiens_hsa047271.14909924
22Tuberculosis_Homo sapiens_hsa051521.09573927
23Regulation of autophagy_Homo sapiens_hsa041401.05540693
24Graft-versus-host disease_Homo sapiens_hsa053321.04317140
25Complement and coagulation cascades_Homo sapiens_hsa046101.00165679
26NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98674745
27Leishmaniasis_Homo sapiens_hsa051400.96681265
28Retinol metabolism_Homo sapiens_hsa008300.93714439
29Autoimmune thyroid disease_Homo sapiens_hsa053200.92639774
30Sulfur relay system_Homo sapiens_hsa041220.92418656
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92008618
32Arachidonic acid metabolism_Homo sapiens_hsa005900.91923651
33Cholinergic synapse_Homo sapiens_hsa047250.85893207
34Type I diabetes mellitus_Homo sapiens_hsa049400.84291924
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80861893
36Tryptophan metabolism_Homo sapiens_hsa003800.80369797
37Morphine addiction_Homo sapiens_hsa050320.78386947
38Dopaminergic synapse_Homo sapiens_hsa047280.76592861
39Circadian rhythm_Homo sapiens_hsa047100.75737800
40Circadian entrainment_Homo sapiens_hsa047130.75487267
41Glutamatergic synapse_Homo sapiens_hsa047240.74802427
42Malaria_Homo sapiens_hsa051440.73012962
43Nitrogen metabolism_Homo sapiens_hsa009100.71634865
44Caffeine metabolism_Homo sapiens_hsa002320.70638888
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67744153
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62463655
47Serotonergic synapse_Homo sapiens_hsa047260.62007305
48Fanconi anemia pathway_Homo sapiens_hsa034600.60026568
49ABC transporters_Homo sapiens_hsa020100.59231573
50Legionellosis_Homo sapiens_hsa051340.59182451
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57952391
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57497005
53African trypanosomiasis_Homo sapiens_hsa051430.54644037
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52920385
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51816958
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51254887
57Hematopoietic cell lineage_Homo sapiens_hsa046400.51162895
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.51099153
59Insulin secretion_Homo sapiens_hsa049110.49595749
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48101165
61Nicotine addiction_Homo sapiens_hsa050330.47725927
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47189634
63Purine metabolism_Homo sapiens_hsa002300.45765813
64Ovarian steroidogenesis_Homo sapiens_hsa049130.44943352
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.44454953
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43994170
67Toxoplasmosis_Homo sapiens_hsa051450.43120201
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41945509
69Arginine biosynthesis_Homo sapiens_hsa002200.41191235
70Phagosome_Homo sapiens_hsa041450.40987242
71Hedgehog signaling pathway_Homo sapiens_hsa043400.39891794
72Oxytocin signaling pathway_Homo sapiens_hsa049210.39419570
73Viral myocarditis_Homo sapiens_hsa054160.39133619
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.38086221
75Fructose and mannose metabolism_Homo sapiens_hsa000510.36586464
76TNF signaling pathway_Homo sapiens_hsa046680.36480894
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.34985612
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34561803
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34418846
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34410371
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34212520
82cAMP signaling pathway_Homo sapiens_hsa040240.33557015
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33510785
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33354884
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32984870
86Antigen processing and presentation_Homo sapiens_hsa046120.32336648
87Primary immunodeficiency_Homo sapiens_hsa053400.32051456
88Dilated cardiomyopathy_Homo sapiens_hsa054140.31716363
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30151886
90Renin secretion_Homo sapiens_hsa049240.29167362
91Cardiac muscle contraction_Homo sapiens_hsa042600.29040361
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28996250
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28852744
94mTOR signaling pathway_Homo sapiens_hsa041500.28510169
95Inositol phosphate metabolism_Homo sapiens_hsa005620.27667555
96Glycerolipid metabolism_Homo sapiens_hsa005610.27655215
97Fatty acid elongation_Homo sapiens_hsa000620.27636791
98Salivary secretion_Homo sapiens_hsa049700.27523920
99Dorso-ventral axis formation_Homo sapiens_hsa043200.27175742
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27120095
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26722533
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25815541
103Gastric acid secretion_Homo sapiens_hsa049710.25681146
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25610001
105Platelet activation_Homo sapiens_hsa046110.25059391
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25026766
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.24813190
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24233288
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23810627
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23141931
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22732944
112Long-term depression_Homo sapiens_hsa047300.22732494
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.22280065
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.21854274
115Cocaine addiction_Homo sapiens_hsa050300.21782110
116Biosynthesis of amino acids_Homo sapiens_hsa012300.21777465
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21604301
118Long-term potentiation_Homo sapiens_hsa047200.20716564
119Type II diabetes mellitus_Homo sapiens_hsa049300.20570991
120Glucagon signaling pathway_Homo sapiens_hsa049220.20142378
121Galactose metabolism_Homo sapiens_hsa000520.17706821
122Alcoholism_Homo sapiens_hsa050340.17522999
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17377399
124Chemokine signaling pathway_Homo sapiens_hsa040620.16981657
125Calcium signaling pathway_Homo sapiens_hsa040200.16003827
126HIF-1 signaling pathway_Homo sapiens_hsa040660.15503565
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15182933
128Lysine degradation_Homo sapiens_hsa003100.14989692
129AMPK signaling pathway_Homo sapiens_hsa041520.14770415
130Bile secretion_Homo sapiens_hsa049760.14548714
131Amphetamine addiction_Homo sapiens_hsa050310.14267003
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13247102
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11123815
134Ras signaling pathway_Homo sapiens_hsa040140.09770587
135Pancreatic secretion_Homo sapiens_hsa049720.09082670
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07938570
137Collecting duct acid secretion_Homo sapiens_hsa049660.07699536
138GnRH signaling pathway_Homo sapiens_hsa049120.07467151
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.07311374
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.06644708
141Tight junction_Homo sapiens_hsa045300.06576252
142Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06387227
143Insulin resistance_Homo sapiens_hsa049310.06382014
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05246750
145Maturity onset diabetes of the young_Homo sapiens_hsa049500.05188451
146Thyroid hormone synthesis_Homo sapiens_hsa049180.05007933
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.04985859
148MAPK signaling pathway_Homo sapiens_hsa040100.04934530
149mRNA surveillance pathway_Homo sapiens_hsa030150.04360821
150Taste transduction_Homo sapiens_hsa047420.04354235
151Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.04128733
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.03872044
153Mineral absorption_Homo sapiens_hsa049780.03196965
154Cysteine and methionine metabolism_Homo sapiens_hsa002700.02959247
155Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.02469270
156Choline metabolism in cancer_Homo sapiens_hsa052310.01967239
157Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.01573216
158Fat digestion and absorption_Homo sapiens_hsa049750.01482966
159Vitamin digestion and absorption_Homo sapiens_hsa049770.01195877
160Hippo signaling pathway_Homo sapiens_hsa043900.00896189
161Glioma_Homo sapiens_hsa052140.00319239
162Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0040782
163Endocytosis_Homo sapiens_hsa04144-0.0033879

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »