RD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a retinal protein that is associated with promyelocytic leukemia-gene product (PML) bodies in the nucleus. Mutations in this gene cause Leber congenital amaurosis type 12, a disease that results in retinal degeneration. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1photoreceptor cell maintenance (GO:0045494)9.75691457
2retinal cone cell development (GO:0046549)9.53781731
3retinal rod cell development (GO:0046548)9.23462592
4photoreceptor cell development (GO:0042461)8.64148665
5eye photoreceptor cell development (GO:0042462)8.05852967
6sensory perception of chemical stimulus (GO:0007606)7.26669855
7detection of light stimulus (GO:0009583)7.12258712
8phototransduction (GO:0007602)7.08911730
9detection of visible light (GO:0009584)6.98269655
10GMP metabolic process (GO:0046037)6.94366868
11phototransduction, visible light (GO:0007603)6.85837713
12behavioral response to nicotine (GO:0035095)6.42935839
13protein localization to cilium (GO:0061512)6.38136511
14* visual perception (GO:0007601)6.26361414
15* sensory perception of light stimulus (GO:0050953)6.22977874
16protein insertion into membrane (GO:0051205)5.80478634
17positive regulation of guanylate cyclase activity (GO:0031284)5.68991315
18axoneme assembly (GO:0035082)5.52252668
19nonmotile primary cilium assembly (GO:0035058)5.41322567
20protein-chromophore linkage (GO:0018298)5.13755363
21regulation of guanylate cyclase activity (GO:0031282)5.09168025
22axonemal dynein complex assembly (GO:0070286)4.99422505
23photoreceptor cell differentiation (GO:0046530)4.98183707
24eye photoreceptor cell differentiation (GO:0001754)4.98183707
25detection of external stimulus (GO:0009581)4.97714316
26regulation of cilium movement (GO:0003352)4.92345541
27* retina development in camera-type eye (GO:0060041)4.90689948
28cellular response to light stimulus (GO:0071482)4.89412544
29detection of abiotic stimulus (GO:0009582)4.88405070
30adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.84480966
31negative regulation of cytosolic calcium ion concentration (GO:0051481)4.81483621
32platelet dense granule organization (GO:0060155)4.32121734
33intraciliary transport (GO:0042073)4.28211747
34tachykinin receptor signaling pathway (GO:0007217)4.24834586
35cilium movement (GO:0003341)4.22756370
36fucose catabolic process (GO:0019317)4.21503105
37L-fucose metabolic process (GO:0042354)4.21503105
38L-fucose catabolic process (GO:0042355)4.21503105
39motile cilium assembly (GO:0044458)4.07355613
40response to pheromone (GO:0019236)4.01968287
41regulation of chromatin binding (GO:0035561)3.98928631
42regulation of cGMP metabolic process (GO:0030823)3.86383302
43behavioral response to cocaine (GO:0048148)3.85491479
44cellular potassium ion homeostasis (GO:0030007)3.80697157
45cilium morphogenesis (GO:0060271)3.79868547
46potassium ion homeostasis (GO:0055075)3.76028679
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.75282152
48negative regulation of transcription regulatory region DNA binding (GO:2000678)3.73923380
49* sensory perception (GO:0007600)3.71595055
50positive regulation of cGMP biosynthetic process (GO:0030828)3.69784746
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.63838550
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.59970026
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.58051677
54pyrimidine nucleobase catabolic process (GO:0006208)3.54178823
55protein polyglutamylation (GO:0018095)3.51854649
56regulation of voltage-gated calcium channel activity (GO:1901385)3.50559366
57indolalkylamine metabolic process (GO:0006586)3.45758862
58regulation of cGMP biosynthetic process (GO:0030826)3.44293100
59cilium organization (GO:0044782)3.43662194
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.42010139
61regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.41726514
62regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.41726514
63epithelial cilium movement (GO:0003351)3.41168252
64dopamine receptor signaling pathway (GO:0007212)3.40922383
65auditory receptor cell stereocilium organization (GO:0060088)3.38941976
66cilium assembly (GO:0042384)3.35191309
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34412043
68mating behavior (GO:0007617)3.32582050
69sensory perception of taste (GO:0050909)3.29956577
70sodium ion export (GO:0071436)3.24075959
71cilium or flagellum-dependent cell motility (GO:0001539)3.23540786
72snRNA transcription (GO:0009301)3.21792839
73positive regulation of cGMP metabolic process (GO:0030825)3.20423079
74lactate metabolic process (GO:0006089)3.19436421
75striatum development (GO:0021756)3.18434159
76kynurenine metabolic process (GO:0070189)3.16861035
77nucleobase catabolic process (GO:0046113)3.16309479
78left/right axis specification (GO:0070986)3.15328922
79startle response (GO:0001964)3.13657425
80inner ear receptor stereocilium organization (GO:0060122)3.13403232
81regulation of hexokinase activity (GO:1903299)3.11502215
82regulation of glucokinase activity (GO:0033131)3.11502215
83regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.11090140
84microtubule bundle formation (GO:0001578)3.09506695
85cornea development in camera-type eye (GO:0061303)3.08850493
86inner ear receptor cell differentiation (GO:0060113)3.07837108
87cellular response to radiation (GO:0071478)3.07796756
88melanosome transport (GO:0032402)3.07197315
89behavioral response to ethanol (GO:0048149)3.06525930
90protein localization to synapse (GO:0035418)3.06454026
91peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.05455726
92indole-containing compound catabolic process (GO:0042436)3.01798681
93indolalkylamine catabolic process (GO:0046218)3.01798681
94tryptophan catabolic process (GO:0006569)3.01798681
95neuronal action potential propagation (GO:0019227)3.00406231
96proline transport (GO:0015824)2.98639861
97phosphorelay signal transduction system (GO:0000160)2.98135682
98synaptic transmission, cholinergic (GO:0007271)2.95568982
99neural tube formation (GO:0001841)2.94424321
100establishment of melanosome localization (GO:0032401)2.92013211
101pigment granule transport (GO:0051904)2.91582944
102cellular ketone body metabolic process (GO:0046950)2.90221208
103protein-cofactor linkage (GO:0018065)2.89624256
104neuron development (GO:0048666)2.87425520
105piRNA metabolic process (GO:0034587)2.87404094
106water-soluble vitamin biosynthetic process (GO:0042364)2.87011483
107response to light stimulus (GO:0009416)2.85500670
108synaptic vesicle endocytosis (GO:0048488)2.84664101
109receptor guanylyl cyclase signaling pathway (GO:0007168)2.84155643
110dendritic spine morphogenesis (GO:0060997)2.83003940
111cell proliferation in forebrain (GO:0021846)2.81674797
112cellular potassium ion transport (GO:0071804)2.81207787
113potassium ion transmembrane transport (GO:0071805)2.81207787
114regulation of microtubule-based movement (GO:0060632)2.79227951
115synaptic vesicle docking involved in exocytosis (GO:0016081)2.78941751
116mitochondrial respiratory chain complex I assembly (GO:0032981)2.78666381
117NADH dehydrogenase complex assembly (GO:0010257)2.78666381
118mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78666381
119adaptation of signaling pathway (GO:0023058)2.77977106
120establishment of pigment granule localization (GO:0051905)2.77798771
121indole-containing compound metabolic process (GO:0042430)2.77629961
122melanosome localization (GO:0032400)2.76475214
123positive regulation of gastrulation (GO:2000543)2.76245582
124neuronal action potential (GO:0019228)2.75049270
125ketone body metabolic process (GO:1902224)2.72454004
126negative regulation of astrocyte differentiation (GO:0048712)2.71618469
127reflex (GO:0060004)2.71527046
128retina homeostasis (GO:0001895)2.71146167
129DNA methylation involved in gamete generation (GO:0043046)2.70158148
130potassium ion export (GO:0071435)2.69597259
131negative regulation of reactive oxygen species metabolic process (GO:2000378)2.68941316
132transmission of nerve impulse (GO:0019226)2.68377019
133gamma-aminobutyric acid transport (GO:0015812)2.68127376
134membrane hyperpolarization (GO:0060081)2.67873824
135negative regulation of telomere maintenance (GO:0032205)2.67601868
136synaptic vesicle exocytosis (GO:0016079)2.67452993
137primary amino compound metabolic process (GO:1901160)2.66867399
138positive regulation of neurotransmitter transport (GO:0051590)2.64507233
139pigment granule localization (GO:0051875)2.64092727
140cell morphogenesis involved in neuron differentiation (GO:0048667)2.62740705
141DNA deamination (GO:0045006)2.62726442
142replication fork processing (GO:0031297)2.60567490
143protein complex biogenesis (GO:0070271)2.60541173
144protein heterotetramerization (GO:0051290)2.60362658
145preassembly of GPI anchor in ER membrane (GO:0016254)2.60183204
146cellular component assembly involved in morphogenesis (GO:0010927)2.58857673
147L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55831852
148cAMP catabolic process (GO:0006198)2.54126098
149auditory behavior (GO:0031223)2.52560778
150anterograde synaptic vesicle transport (GO:0048490)2.50289977
151rRNA catabolic process (GO:0016075)2.48700461
152reciprocal DNA recombination (GO:0035825)2.48680240
153reciprocal meiotic recombination (GO:0007131)2.48680240
154RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.48600200
155positive regulation of digestive system process (GO:0060456)2.48114526
156serotonin metabolic process (GO:0042428)2.46318274
157ubiquinone biosynthetic process (GO:0006744)2.46269237
158glycerophospholipid catabolic process (GO:0046475)2.45901606
159tryptophan metabolic process (GO:0006568)2.45850025
160retinal ganglion cell axon guidance (GO:0031290)2.45148869
161negative regulation of mast cell activation (GO:0033004)2.44976618
162phosphatidylinositol acyl-chain remodeling (GO:0036149)2.44531982
163parturition (GO:0007567)2.43020521
164regulation of action potential (GO:0098900)2.42420732
165protein K11-linked deubiquitination (GO:0035871)2.42142770
166negative regulation of DNA-dependent DNA replication (GO:2000104)2.42080877
167postsynaptic membrane organization (GO:0001941)2.41265077
168regulation of rhodopsin mediated signaling pathway (GO:0022400)11.2920138
169rhodopsin mediated signaling pathway (GO:0016056)11.2184224
170sensory perception of smell (GO:0007608)10.9579281
171detection of light stimulus involved in sensory perception (GO:0050962)10.2513854
172detection of light stimulus involved in visual perception (GO:0050908)10.2513854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.75425908
2ZNF274_21170338_ChIP-Seq_K562_Hela3.54029543
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.52882857
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.10997403
5GBX2_23144817_ChIP-Seq_PC3_Human2.87952974
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78674417
7DROSHA_22980978_ChIP-Seq_HELA_Human2.65596912
8VDR_22108803_ChIP-Seq_LS180_Human2.57755255
9CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.49644191
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21090045
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.15645828
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11171295
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.04391117
14REST_21632747_ChIP-Seq_MESCs_Mouse2.03426512
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00610515
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98952221
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95419123
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92816309
19CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92184806
20FUS_26573619_Chip-Seq_HEK293_Human1.89893654
21GATA1_26923725_Chip-Seq_HPCs_Mouse1.88520196
22EWS_26573619_Chip-Seq_HEK293_Human1.87478136
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86850045
24* EZH2_27294783_Chip-Seq_ESCs_Mouse1.85370368
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82610065
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81354105
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65005235
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64215453
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61597595
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60753520
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59480057
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59480057
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56077644
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.55144077
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54786344
36RNF2_27304074_Chip-Seq_NSC_Mouse1.51249948
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50963801
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.49702701
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49010866
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48295721
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48251878
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45402852
43TP53_22573176_ChIP-Seq_HFKS_Human1.44984557
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44278881
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.42732436
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42058314
47IRF1_19129219_ChIP-ChIP_H3396_Human1.41380517
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40121709
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39291284
50NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.38981728
51P53_22127205_ChIP-Seq_FIBROBLAST_Human1.38658057
52SMAD4_21799915_ChIP-Seq_A2780_Human1.38465717
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37453570
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37453570
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.37446352
56AR_25329375_ChIP-Seq_VCAP_Human1.37010032
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35105762
58PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.34766102
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34663251
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.33959508
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33447422
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33439391
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32885668
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32616062
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32162484
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.30436409
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29809333
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28605286
69AR_21572438_ChIP-Seq_LNCaP_Human1.27954540
70* TCF4_22108803_ChIP-Seq_LS180_Human1.26267485
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25754825
72SOX2_19829295_ChIP-Seq_ESCs_Human1.25409601
73NANOG_19829295_ChIP-Seq_ESCs_Human1.25409601
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24766327
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24587267
76MYC_18940864_ChIP-ChIP_HL60_Human1.23620536
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23318043
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.23109805
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22867950
80RUNX2_22187159_ChIP-Seq_PCA_Human1.22083510
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21820458
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20568199
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20045464
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.19398599
85AHR_22903824_ChIP-Seq_MCF-7_Human1.18867681
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.18605668
87GF1_26923725_Chip-Seq_HPCs_Mouse1.18103862
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17806167
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17221617
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16976748
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.16793674
92ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16016804
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15805705
94KDM2B_26808549_Chip-Seq_K562_Human1.14745701
95POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14608576
96WDR5_24793694_ChIP-Seq_LNCAP_Human1.13755744
97P300_19829295_ChIP-Seq_ESCs_Human1.13522221
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13403963
99IGF1R_20145208_ChIP-Seq_DFB_Human1.13165128
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.12415282
101FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12415282
102* NANOG_18555785_Chip-Seq_ESCs_Mouse1.12352786
103GATA3_21878914_ChIP-Seq_MCF-7_Human1.12285245
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.12040152
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10743813
106* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10528660
107TAF15_26573619_Chip-Seq_HEK293_Human1.09916811
108* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08592559
109GABP_17652178_ChIP-ChIP_JURKAT_Human1.08026444
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07958162
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07138457
112* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.07048141
113RARB_27405468_Chip-Seq_BRAIN_Mouse1.06341805
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06316406
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.06101778
116CTCF_27219007_Chip-Seq_Bcells_Human1.05697475
117NCOR_22424771_ChIP-Seq_293T_Human1.05221360
118* P53_22387025_ChIP-Seq_ESCs_Mouse1.04951365
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.03907679
120* AR_19668381_ChIP-Seq_PC3_Human1.02785175
121SMAD4_21741376_ChIP-Seq_HESCs_Human1.02663997
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02517989
123* STAT3_23295773_ChIP-Seq_U87_Human1.02181143
124TAL1_26923725_Chip-Seq_HPCs_Mouse1.01876020
125CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00669390
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00432073
127* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00279628
128HOXB7_26014856_ChIP-Seq_BT474_Human0.99974562
129* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99364452
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99184037
131AR_20517297_ChIP-Seq_VCAP_Human0.98950239
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98775890
133CTCF_20526341_ChIP-Seq_ESCs_Human0.98145143
134TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97666569
135FLI1_21867929_ChIP-Seq_TH2_Mouse0.97021538
136ER_23166858_ChIP-Seq_MCF-7_Human0.96588525
137* SMAD4_21741376_ChIP-Seq_EPCs_Human0.96569575
138STAT1_17558387_ChIP-Seq_HELA_Human0.96264755
139* CRX_20693478_ChIP-Seq_RETINA_Mouse0.96204812
140BCAT_22108803_ChIP-Seq_LS180_Human0.96053719
141CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96040565
142OCT4_20526341_ChIP-Seq_ESCs_Human0.95551223
143EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95505511
144PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95311800
145PRDM14_20953172_ChIP-Seq_ESCs_Human0.94417661
146* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93962031
147TCF4_23295773_ChIP-Seq_U87_Human0.93948536
148SMC4_20622854_ChIP-Seq_HELA_Human0.93880318
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93260908
150ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92478123
151CBP_20019798_ChIP-Seq_JUKART_Human0.91286525
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91286525
153SMAD3_21741376_ChIP-Seq_ESCs_Human0.90584172
154CBP_21632823_ChIP-Seq_H3396_Human0.90486693
155NANOG_20526341_ChIP-Seq_ESCs_Human0.89536928
156FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88991089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction8.41487104
2* MP0005551_abnormal_eye_electrophysiolog7.72963769
3MP0003011_delayed_dark_adaptation6.64114678
4MP0006072_abnormal_retinal_apoptosis5.25327096
5MP0005253_abnormal_eye_physiology4.97747083
6MP0008789_abnormal_olfactory_epithelium3.90855597
7MP0005499_abnormal_olfactory_system3.59420575
8MP0005394_taste/olfaction_phenotype3.59420575
9MP0005195_abnormal_posterior_eye3.31762400
10MP0003195_calcinosis3.02106488
11MP0001324_abnormal_eye_pigmentation2.70164562
12MP0005391_vision/eye_phenotype2.59362184
13MP0002090_abnormal_vision2.51377017
14MP0001968_abnormal_touch/_nociception2.41483943
15MP0003950_abnormal_plasma_membrane2.39233479
16MP0002653_abnormal_ependyma_morphology2.34595625
17MP0003646_muscle_fatigue2.32125132
18* MP0002752_abnormal_somatic_nervous2.14164005
19MP0000569_abnormal_digit_pigmentation2.07416704
20* MP0002229_neurodegeneration2.06540987
21MP0002638_abnormal_pupillary_reflex2.04757796
22MP0002837_dystrophic_cardiac_calcinosis1.89605556
23MP0000372_irregular_coat_pigmentation1.89519875
24MP0005423_abnormal_somatic_nervous1.89240498
25MP0002736_abnormal_nociception_after1.89138548
26MP0008872_abnormal_physiological_respon1.86593018
27MP0009745_abnormal_behavioral_response1.84578040
28MP0004147_increased_porphyrin_level1.83609226
29MP0004142_abnormal_muscle_tone1.76741296
30MP0001501_abnormal_sleep_pattern1.72827815
31MP0002876_abnormal_thyroid_physiology1.64800838
32MP0002882_abnormal_neuron_morphology1.56781901
33MP0002735_abnormal_chemical_nociception1.55879911
34MP0005645_abnormal_hypothalamus_physiol1.51981244
35MP0002938_white_spotting1.50980425
36MP0002822_catalepsy1.46040404
37MP0002184_abnormal_innervation1.45529986
38MP0001502_abnormal_circadian_rhythm1.45151955
39MP0000427_abnormal_hair_cycle1.41887152
40MP0004782_abnormal_surfactant_physiolog1.41077925
41MP0003890_abnormal_embryonic-extraembry1.36800925
42MP0002234_abnormal_pharynx_morphology1.35819460
43MP0003122_maternal_imprinting1.33873897
44MP0006292_abnormal_olfactory_placode1.33061862
45MP0003121_genomic_imprinting1.32504161
46MP0002734_abnormal_mechanical_nocicepti1.31593737
47MP0002163_abnormal_gland_morphology1.30153570
48MP0002733_abnormal_thermal_nociception1.29630924
49MP0001970_abnormal_pain_threshold1.27510596
50MP0001486_abnormal_startle_reflex1.26151805
51MP0005410_abnormal_fertilization1.24207594
52MP0001529_abnormal_vocalization1.23966470
53MP0002272_abnormal_nervous_system1.22232062
54MP0004043_abnormal_pH_regulation1.22147961
55MP0005248_abnormal_Harderian_gland1.21882833
56MP0004924_abnormal_behavior1.17776317
57MP0005386_behavior/neurological_phenoty1.17776317
58MP0001188_hyperpigmentation1.15753057
59MP0005187_abnormal_penis_morphology1.11343962
60MP0001764_abnormal_homeostasis1.08443268
61MP0005377_hearing/vestibular/ear_phenot1.08050613
62MP0003878_abnormal_ear_physiology1.08050613
63MP0005174_abnormal_tail_pigmentation1.07509673
64MP0001986_abnormal_taste_sensitivity1.06803424
65MP0005075_abnormal_melanosome_morpholog1.04941546
66MP0010386_abnormal_urinary_bladder1.03766523
67MP0010030_abnormal_orbit_morphology1.00908707
68MP0002928_abnormal_bile_duct0.98009393
69MP0001440_abnormal_grooming_behavior0.96595003
70MP0001905_abnormal_dopamine_level0.96423458
71MP0003943_abnormal_hepatobiliary_system0.95774320
72MP0001919_abnormal_reproductive_system0.95159491
73MP0002160_abnormal_reproductive_system0.92422814
74MP0004742_abnormal_vestibular_system0.91568887
75MP0003283_abnormal_digestive_organ0.89094313
76MP0008995_early_reproductive_senescence0.88911038
77MP0000230_abnormal_systemic_arterial0.88363731
78MP0003136_yellow_coat_color0.87441837
79MP0005379_endocrine/exocrine_gland_phen0.84956126
80MP0001485_abnormal_pinna_reflex0.84140959
81MP0003634_abnormal_glial_cell0.83693221
82MP0008775_abnormal_heart_ventricle0.82936619
83MP0000631_abnormal_neuroendocrine_gland0.82676763
84MP0001346_abnormal_lacrimal_gland0.82563226
85MP0003718_maternal_effect0.79535770
86MP0001293_anophthalmia0.79312940
87MP0003119_abnormal_digestive_system0.78582510
88MP0002138_abnormal_hepatobiliary_system0.78045157
89MP0002067_abnormal_sensory_capabilities0.77901249
90MP0002233_abnormal_nose_morphology0.77777326
91MP0002557_abnormal_social/conspecific_i0.76835982
92MP0004270_analgesia0.76353021
93MP0005646_abnormal_pituitary_gland0.75942755
94MP0001963_abnormal_hearing_physiology0.75688274
95MP0003698_abnormal_male_reproductive0.70434484
96MP0004145_abnormal_muscle_electrophysio0.69687972
97MP0003635_abnormal_synaptic_transmissio0.69308125
98MP0004233_abnormal_muscle_weight0.68324650
99MP0002102_abnormal_ear_morphology0.66985068
100MP0003787_abnormal_imprinting0.66262416
101MP0000026_abnormal_inner_ear0.65289317
102MP0004885_abnormal_endolymph0.64784105
103MP0000778_abnormal_nervous_system0.64580015
104MP0002152_abnormal_brain_morphology0.64426661
105MP0005197_abnormal_uvea_morphology0.64212953
106MP0001286_abnormal_eye_development0.63995886
107MP0004019_abnormal_vitamin_homeostasis0.63657079
108MP0002127_abnormal_cardiovascular_syste0.61830164
109MP0009046_muscle_twitch0.60142739
110MP0005084_abnormal_gallbladder_morpholo0.59669971
111MP0002063_abnormal_learning/memory/cond0.59580750
112MP0004133_heterotaxia0.58920510
113MP0002064_seizures0.58712124
114MP0002332_abnormal_exercise_endurance0.58064608
115MP0008058_abnormal_DNA_repair0.57837108
116MP0003880_abnormal_central_pattern0.57060058
117MP0006276_abnormal_autonomic_nervous0.56383009
118MP0005220_abnormal_exocrine_pancreas0.55865242
119MP0001542_abnormal_bone_strength0.54841693
120MP0008004_abnormal_stomach_pH0.53205552
121MP0004811_abnormal_neuron_physiology0.50537768
122MP0004215_abnormal_myocardial_fiber0.49341680
123MP0002697_abnormal_eye_size0.49242125
124MP0005365_abnormal_bile_salt0.46360040
125MP0003861_abnormal_nervous_system0.45020554
126MP0002572_abnormal_emotion/affect_behav0.43732798
127MP0008875_abnormal_xenobiotic_pharmacok0.43402261
128MP0003252_abnormal_bile_duct0.41648443
129MP0005367_renal/urinary_system_phenotyp0.40941779
130MP0000516_abnormal_urinary_system0.40941779
131MP0004134_abnormal_chest_morphology0.40753224
132MP0003879_abnormal_hair_cell0.38515050
133MP0002751_abnormal_autonomic_nervous0.37161515
134MP0008877_abnormal_DNA_methylation0.36859252
135MP0005595_abnormal_vascular_smooth0.36818087
136MP0002909_abnormal_adrenal_gland0.35059824
137MP0000955_abnormal_spinal_cord0.34749018
138MP0004085_abnormal_heartbeat0.33089823
139MP0002161_abnormal_fertility/fecundity0.32815821
140MP0005389_reproductive_system_phenotype0.32403210
141MP0003942_abnormal_urinary_system0.32143880
142MP0000003_abnormal_adipose_tissue0.31689155
143MP0003633_abnormal_nervous_system0.30859812

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)9.39795065
2Abnormal rod and cone electroretinograms (HP:0008323)8.64045996
3Absent rod-and cone-mediated responses on ERG (HP:0007688)8.24225874
4Central scotoma (HP:0000603)7.71957801
5Pigmentary retinal degeneration (HP:0001146)6.59341340
6Decreased central vision (HP:0007663)6.40426628
7Chorioretinal atrophy (HP:0000533)6.13754683
8Abolished electroretinogram (ERG) (HP:0000550)6.02617276
9Scotoma (HP:0000575)6.02083958
10Dyschromatopsia (HP:0007641)5.98607900
11* Abnormality of macular pigmentation (HP:0008002)5.70557140
12Attenuation of retinal blood vessels (HP:0007843)5.61355884
13Pendular nystagmus (HP:0012043)5.46838429
14Severe visual impairment (HP:0001141)5.35260300
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.86442703
16Type II diabetes mellitus (HP:0005978)4.65749546
17Increased corneal curvature (HP:0100692)4.52411140
18Keratoconus (HP:0000563)4.52411140
19Photophobia (HP:0000613)4.42819319
20Cone-rod dystrophy (HP:0000548)4.26677748
21Constricted visual fields (HP:0001133)4.14378637
22Retinitis pigmentosa (HP:0000510)4.12692610
23Abnormal respiratory motile cilium physiology (HP:0012261)4.08422131
24Gait imbalance (HP:0002141)3.98760640
25Congenital primary aphakia (HP:0007707)3.96027668
26Medial flaring of the eyebrow (HP:0010747)3.77138682
27Macular degeneration (HP:0000608)3.62895041
28Nephrogenic diabetes insipidus (HP:0009806)3.59334088
29Posterior subcapsular cataract (HP:0007787)3.53895730
30True hermaphroditism (HP:0010459)3.52971825
31Abnormal ciliary motility (HP:0012262)3.46583845
32Pancreatic fibrosis (HP:0100732)3.45050799
33Vitreoretinal degeneration (HP:0000655)3.34524853
34Rhinitis (HP:0012384)3.26949437
35Choroideremia (HP:0001139)3.24322912
36Type II lissencephaly (HP:0007260)3.22663926
37Abnormal respiratory motile cilium morphology (HP:0005938)3.13437747
38Abnormal respiratory epithelium morphology (HP:0012253)3.13437747
39Poor coordination (HP:0002370)3.06234405
40Abnormality of the renal cortex (HP:0011035)2.98684030
41Aplasia/Hypoplasia of the spleen (HP:0010451)2.91820862
42Decreased electroretinogram (ERG) amplitude (HP:0000654)2.83803271
43Hyperventilation (HP:0002883)2.80710862
44Vaginal atresia (HP:0000148)2.76610588
45Abnormality of midbrain morphology (HP:0002418)2.74594437
46Molar tooth sign on MRI (HP:0002419)2.74594437
47Genital tract atresia (HP:0001827)2.74400283
48Intestinal atresia (HP:0011100)2.71193024
49Absent/shortened dynein arms (HP:0200106)2.69760380
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.69760380
51Supernumerary spleens (HP:0009799)2.68515364
52Asplenia (HP:0001746)2.66810852
53Pancreatic cysts (HP:0001737)2.63692781
54Chronic bronchitis (HP:0004469)2.60754453
55Tubular atrophy (HP:0000092)2.56866965
56Cystic liver disease (HP:0006706)2.56441718
57Congenital sensorineural hearing impairment (HP:0008527)2.47481640
58Lissencephaly (HP:0001339)2.45071147
59Abnormal drinking behavior (HP:0030082)2.43457881
60Polydipsia (HP:0001959)2.43457881
61Subcapsular cataract (HP:0000523)2.42044919
62Aplasia/Hypoplasia of the lens (HP:0008063)2.41225869
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.34307779
64Febrile seizures (HP:0002373)2.33631813
65Gaze-evoked nystagmus (HP:0000640)2.29001303
66Focal motor seizures (HP:0011153)2.28144260
67Renal cortical cysts (HP:0000803)2.25687434
68Nephronophthisis (HP:0000090)2.20480319
69Focal seizures (HP:0007359)2.19661935
70Progressive visual loss (HP:0000529)2.19480860
71Cerebellar dysplasia (HP:0007033)2.15013383
72Optic disc pallor (HP:0000543)2.13674113
73Neoplasm of the adrenal cortex (HP:0100641)2.12800093
74Lipid accumulation in hepatocytes (HP:0006561)2.12726239
75Inability to walk (HP:0002540)2.10656623
76Decreased circulating renin level (HP:0003351)2.10433473
77Hyperglycinuria (HP:0003108)2.10104028
78Retinal dysplasia (HP:0007973)2.10010630
79Broad-based gait (HP:0002136)2.09278181
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08862264
81Abnormality of the phalanges of the 2nd finger (HP:0009541)2.07865620
82Progressive inability to walk (HP:0002505)2.06791760
83Optic nerve hypoplasia (HP:0000609)2.04834042
84Sclerocornea (HP:0000647)2.04284446
85Progressive cerebellar ataxia (HP:0002073)2.02716215
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00646714
87Abnormality of alanine metabolism (HP:0010916)2.00646714
88Hyperalaninemia (HP:0003348)2.00646714
89Congenital stationary night blindness (HP:0007642)12.8518871
90Pachygyria (HP:0001302)1.98845669
91Postaxial hand polydactyly (HP:0001162)1.97408503
92Recurrent sinusitis (HP:0011108)1.96322163
93Congenital hepatic fibrosis (HP:0002612)1.94495824
94Wide nasal bridge (HP:0000431)1.92971075
95Septo-optic dysplasia (HP:0100842)1.91895336
96Occipital encephalocele (HP:0002085)1.91063722
97Thyroid-stimulating hormone excess (HP:0002925)1.90928781
98Postaxial foot polydactyly (HP:0001830)1.88611142
99Hemiparesis (HP:0001269)1.87854511
100Chronic hepatic failure (HP:0100626)1.87260493
101Limb dystonia (HP:0002451)1.83913454
102Aplasia/Hypoplasia of the tibia (HP:0005772)1.83621579
103Abnormality of the labia minora (HP:0012880)1.83369263
104Dialeptic seizures (HP:0011146)1.83222908
105Concave nail (HP:0001598)1.82708690
106Polyuria (HP:0000103)1.81890737
107Increased hepatocellular lipid droplets (HP:0006565)1.79768689
108Acute necrotizing encephalopathy (HP:0006965)1.78491817
109Narrow forehead (HP:0000341)1.78097208
110Mitochondrial inheritance (HP:0001427)1.77460254
111Agitation (HP:0000713)1.76680182
112Bronchiectasis (HP:0002110)1.75901331
113Genetic anticipation (HP:0003743)1.75577510
114Hypothermia (HP:0002045)1.75297798
115Increased CSF lactate (HP:0002490)1.75003242
116Abnormality of the fovea (HP:0000493)1.73923702
117Abnormality of the renal medulla (HP:0100957)1.72978580
118Astigmatism (HP:0000483)1.71482045
119Decreased testicular size (HP:0008734)1.70915707
120Left ventricular hypertrophy (HP:0001712)1.68583818
121Prolonged QT interval (HP:0001657)1.67037219
122Male pseudohermaphroditism (HP:0000037)1.67000418
123Furrowed tongue (HP:0000221)1.63555087
124Hypoplasia of the fovea (HP:0007750)1.62716598
125Aplasia/Hypoplasia of the fovea (HP:0008060)1.62716598
126Specific learning disability (HP:0001328)1.59194668
127Broad foot (HP:0001769)1.58848010
128Anencephaly (HP:0002323)1.57411562
129Tubulointerstitial nephritis (HP:0001970)1.56940051
130Median cleft lip (HP:0000161)1.55093748
131Epileptic encephalopathy (HP:0200134)1.53706431
132Oculomotor apraxia (HP:0000657)1.53552508
133Absence seizures (HP:0002121)1.52510298
134Bifid tongue (HP:0010297)1.48916296
135Sex reversal (HP:0012245)1.48813123
136Abnormal sex determination (HP:0012244)1.48813123
137Asthma (HP:0002099)1.44347281
138* Optic atrophy (HP:0000648)1.43786704
139Palpitations (HP:0001962)1.42232835
140Retinal atrophy (HP:0001105)1.42155501
141Recurrent otitis media (HP:0000403)1.38792470
142Syncope (HP:0001279)1.36739853
143Anosmia (HP:0000458)1.36356204
144Severe Myopia (HP:0011003)1.32588854
145Abnormal biliary tract physiology (HP:0012439)1.32392079
146Bile duct proliferation (HP:0001408)1.32392079
147Abnormality of dentin (HP:0010299)1.31189573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.48508335
2GRK14.76164573
3EEF2K4.02024512
4ERBB33.96706530
5PHKG23.46962450
6PHKG13.46962450
7MAPKAPK33.27871671
8ADRBK22.96335846
9MAP4K22.79984419
10BMPR1B2.67903892
11ZAK2.60379547
12PRPF4B2.56878671
13PBK2.54194181
14PINK12.51212509
15WNK32.50990071
16MAPK152.47470509
17CASK2.41928739
18IRAK22.19588307
19ICK2.07004261
20STK38L2.05731342
21INSRR2.03669878
22OXSR11.94504486
23DAPK21.92065626
24WNK41.87977891
25BMPR21.81631731
26TLK11.73147768
27TXK1.72579928
28CDK31.70811002
29CAMK2D1.58877001
30ACVR1B1.58788585
31MAPK131.57011613
32CAMK1G1.55369765
33PNCK1.54269167
34TAOK31.52617407
35DYRK21.52578697
36STK391.48278957
37NTRK31.44891304
38STK381.42917248
39PLK41.37930427
40PAK31.36776520
41SIK21.31525488
42MKNK21.29678511
43MAPK71.29457312
44MAP3K101.28364030
45MARK11.24581332
46SGK2231.20648466
47SGK4941.20648466
48NEK11.17325064
49MAPKAPK51.16856425
50RIPK11.16650101
51NUAK11.16081797
52DYRK1A1.14859878
53BCR1.10700228
54TIE11.09579257
55DYRK1B1.08911785
56CDK191.05917995
57BCKDK1.05237639
58TNK20.99989960
59MAP3K40.97601265
60PRKCE0.96541016
61PLK20.94063851
62VRK10.93879226
63PRKAA10.92991222
64TNIK0.91782300
65CAMK1D0.90857994
66CDK90.90286569
67HIPK20.88747337
68TRPM70.88736536
69AKT30.88304293
70FGFR20.85735604
71TRIM280.85415694
72CAMKK20.84377815
73CAMK2B0.84130177
74PRKCG0.83906421
75MAP2K70.83497662
76TAF10.83069484
77TGFBR10.81188218
78RPS6KB20.80496163
79ARAF0.80230839
80CSNK1A1L0.80131425
81RPS6KA20.79194276
82MAPK120.78669778
83VRK20.76873681
84MATK0.75544632
85PIK3CA0.75403934
86PRKAA20.75161975
87BRD40.73470923
88IRAK10.70669635
89STK110.69983563
90MAP2K60.69727384
91CAMK2G0.69611412
92TEC0.69200721
93PKN10.67979355
94MKNK10.67870605
95EIF2AK30.67737797
96PAK60.65779720
97PRKCZ0.65460683
98KIT0.62416579
99STK240.61625427
100PRKCQ0.60965609
101DYRK30.59543657
102DAPK10.58945537
103PRKD30.58800956
104EPHA40.58600298
105CSNK1G20.58266428
106CSNK1G30.57941642
107NEK20.57278998
108CAMK2A0.56847573
109MUSK0.56188662
110SGK20.55132369
111PRKCI0.53246144
112STK160.52992083
113TAOK20.51010993
114ERBB20.50969795
115GRK50.50808144
116NME10.50749930
117CDK120.50249621
118SIK30.49463074
119ITK0.48542728
120MAP3K70.47727474
121CAMKK10.47658790
122CCNB10.46496828
123PASK0.45976088
124MINK10.45527399
125RPS6KA40.45182516
126BRSK20.45069300
127PTK2B0.42057126
128IKBKB0.41932014
129PRKG10.40903436
130CSNK1A10.40695885
131PRKCH0.39385248
132MAPK90.39136325
133ADRBK10.38705958
134MARK20.38123492
135LIMK10.38113500
136CLK10.38044901
137BRAF0.36982205
138PRKCB0.36223016
139IGF1R0.35612340
140MARK30.35590265
141MAP2K40.35251695
142PLK30.35016808
143CSNK1G10.34835169
144PLK10.34745408
145TTK0.34666831
146CAMK10.34131186
147PRKCA0.34054320
148CDK50.33792486
149MAPKAPK20.33737515
150RPS6KA50.32760971
151PRKD20.32184905
152RPS6KB10.31556882
153PRKACA0.31057069
154MAPK100.30860883
155CSNK1D0.30388603
156GSK3B0.30354713
157NTRK20.29929994
158PRKACG0.28358066
159MAPK110.28216280

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047406.51911953
2Linoleic acid metabolism_Homo sapiens_hsa005912.73334070
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.68869311
4Synaptic vesicle cycle_Homo sapiens_hsa047212.31461582
5Butanoate metabolism_Homo sapiens_hsa006502.28771976
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23995221
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22255345
8GABAergic synapse_Homo sapiens_hsa047272.12476246
9Oxidative phosphorylation_Homo sapiens_hsa001902.00717311
10Phototransduction_Homo sapiens_hsa0474412.3546425
11Morphine addiction_Homo sapiens_hsa050321.98682650
12Nitrogen metabolism_Homo sapiens_hsa009101.97396778
13Selenocompound metabolism_Homo sapiens_hsa004501.96921462
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93006662
15Basal transcription factors_Homo sapiens_hsa030221.86549926
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86061630
17Tryptophan metabolism_Homo sapiens_hsa003801.84856553
18Protein export_Homo sapiens_hsa030601.79182249
19Ether lipid metabolism_Homo sapiens_hsa005651.72353094
20Circadian entrainment_Homo sapiens_hsa047131.65630329
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64531694
22Caffeine metabolism_Homo sapiens_hsa002321.58656640
23RNA polymerase_Homo sapiens_hsa030201.54990038
24Parkinsons disease_Homo sapiens_hsa050121.54103229
25Propanoate metabolism_Homo sapiens_hsa006401.42789446
26Cholinergic synapse_Homo sapiens_hsa047251.39720976
27Insulin secretion_Homo sapiens_hsa049111.39076335
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29842131
29Homologous recombination_Homo sapiens_hsa034401.28803439
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28289594
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26979617
32Dopaminergic synapse_Homo sapiens_hsa047281.25890354
33Glutamatergic synapse_Homo sapiens_hsa047241.23761123
34One carbon pool by folate_Homo sapiens_hsa006701.23634786
35Arachidonic acid metabolism_Homo sapiens_hsa005901.21867248
36RNA degradation_Homo sapiens_hsa030181.20214471
37Fanconi anemia pathway_Homo sapiens_hsa034601.14637843
38Taste transduction_Homo sapiens_hsa047421.13377799
39Nicotine addiction_Homo sapiens_hsa050331.13182942
40Regulation of autophagy_Homo sapiens_hsa041401.12804471
41Sulfur metabolism_Homo sapiens_hsa009201.11597818
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05952480
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00813921
44Huntingtons disease_Homo sapiens_hsa050160.99861101
45Serotonergic synapse_Homo sapiens_hsa047260.97176661
46ABC transporters_Homo sapiens_hsa020100.92335737
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91595906
48Alzheimers disease_Homo sapiens_hsa050100.91440564
49Circadian rhythm_Homo sapiens_hsa047100.91364278
50Retinol metabolism_Homo sapiens_hsa008300.90759210
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.89108607
52Fat digestion and absorption_Homo sapiens_hsa049750.88988242
53Chemical carcinogenesis_Homo sapiens_hsa052040.85213558
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85015884
55Salivary secretion_Homo sapiens_hsa049700.83315069
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82170473
57Collecting duct acid secretion_Homo sapiens_hsa049660.81108380
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80715987
59Alcoholism_Homo sapiens_hsa050340.78249761
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74935014
61cAMP signaling pathway_Homo sapiens_hsa040240.74481399
62Renin secretion_Homo sapiens_hsa049240.74043930
63Fatty acid degradation_Homo sapiens_hsa000710.73941096
64beta-Alanine metabolism_Homo sapiens_hsa004100.73889684
65Oxytocin signaling pathway_Homo sapiens_hsa049210.72738050
66Long-term depression_Homo sapiens_hsa047300.72296885
67Fatty acid metabolism_Homo sapiens_hsa012120.71780843
68Fructose and mannose metabolism_Homo sapiens_hsa000510.71654280
69Purine metabolism_Homo sapiens_hsa002300.70585713
70Ovarian steroidogenesis_Homo sapiens_hsa049130.69303882
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65472829
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64709576
73Non-homologous end-joining_Homo sapiens_hsa034500.64412903
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61135159
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60781173
76Cardiac muscle contraction_Homo sapiens_hsa042600.59620944
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59066721
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58705767
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57847918
80Metabolic pathways_Homo sapiens_hsa011000.56947035
81Calcium signaling pathway_Homo sapiens_hsa040200.56808922
82Bile secretion_Homo sapiens_hsa049760.56654448
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54838601
84Glucagon signaling pathway_Homo sapiens_hsa049220.53331269
85Pyruvate metabolism_Homo sapiens_hsa006200.53301253
86Gastric acid secretion_Homo sapiens_hsa049710.52490254
87Vibrio cholerae infection_Homo sapiens_hsa051100.51835530
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51677043
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51461377
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49219159
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48703731
92Asthma_Homo sapiens_hsa053100.48677529
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48325953
94Fatty acid elongation_Homo sapiens_hsa000620.47580159
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46376430
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.45258202
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43339760
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41718738
99Inositol phosphate metabolism_Homo sapiens_hsa005620.41131605
100Mineral absorption_Homo sapiens_hsa049780.41100140
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40871054
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.39657263
103Dilated cardiomyopathy_Homo sapiens_hsa054140.39614199
104Arginine and proline metabolism_Homo sapiens_hsa003300.39576061
105Steroid biosynthesis_Homo sapiens_hsa001000.38995207
106Hedgehog signaling pathway_Homo sapiens_hsa043400.38457847
107Thyroid hormone synthesis_Homo sapiens_hsa049180.37600780
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36994539
109Amphetamine addiction_Homo sapiens_hsa050310.35107802
110GnRH signaling pathway_Homo sapiens_hsa049120.35090428
111Dorso-ventral axis formation_Homo sapiens_hsa043200.35079503
112Type II diabetes mellitus_Homo sapiens_hsa049300.34329182
113Sphingolipid metabolism_Homo sapiens_hsa006000.33939996
114Ribosome_Homo sapiens_hsa030100.32752955
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.30954764
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30599606
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.29099094
118Fatty acid biosynthesis_Homo sapiens_hsa000610.27300171
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27296729
120Ras signaling pathway_Homo sapiens_hsa040140.26237963
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26076450
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24821923
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24163037
124Chemokine signaling pathway_Homo sapiens_hsa040620.21323638
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20662501
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.20292358
127Biosynthesis of amino acids_Homo sapiens_hsa012300.20140535
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.19769333
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18400108
130N-Glycan biosynthesis_Homo sapiens_hsa005100.18174855
131Insulin signaling pathway_Homo sapiens_hsa049100.17395273
132Pancreatic secretion_Homo sapiens_hsa049720.17371843
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17058560
134Histidine metabolism_Homo sapiens_hsa003400.16903969
135AMPK signaling pathway_Homo sapiens_hsa041520.16499495
136Notch signaling pathway_Homo sapiens_hsa043300.15596018
137Galactose metabolism_Homo sapiens_hsa000520.14997735
138Melanogenesis_Homo sapiens_hsa049160.14121746
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.13837244
140Peroxisome_Homo sapiens_hsa041460.13722131
141Glycerolipid metabolism_Homo sapiens_hsa005610.13137196
142Cocaine addiction_Homo sapiens_hsa050300.12494675
143Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12092264
144Endometrial cancer_Homo sapiens_hsa052130.11779399
145Primary bile acid biosynthesis_Homo sapiens_hsa001200.11611622
146Gap junction_Homo sapiens_hsa045400.11369721
147Estrogen signaling pathway_Homo sapiens_hsa049150.10856864
148Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10445925
149Axon guidance_Homo sapiens_hsa043600.10370265
150Starch and sucrose metabolism_Homo sapiens_hsa005000.09845421
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.09379046
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08567795
153Long-term potentiation_Homo sapiens_hsa047200.08097898
154Cysteine and methionine metabolism_Homo sapiens_hsa002700.07788517
155Steroid hormone biosynthesis_Homo sapiens_hsa001400.07498835
156Wnt signaling pathway_Homo sapiens_hsa043100.07345306

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