RD3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)9.91228656
2rhodopsin mediated signaling pathway (GO:0016056)9.01319949
3retinal cone cell development (GO:0046549)7.90503385
4regulation of rhodopsin mediated signaling pathway (GO:0022400)7.90459575
5cellular potassium ion homeostasis (GO:0030007)7.60044426
6positive regulation of synapse maturation (GO:0090129)7.44854397
7photoreceptor cell development (GO:0042461)7.12665400
8response to pheromone (GO:0019236)6.90429505
9eye photoreceptor cell development (GO:0042462)6.87807530
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.85502412
11thrombin receptor signaling pathway (GO:0070493)6.69567395
12photoreceptor cell maintenance (GO:0045494)6.51067867
13protein-chromophore linkage (GO:0018298)6.49762614
14regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.26519831
15potassium ion homeostasis (GO:0055075)6.02548876
16ether lipid metabolic process (GO:0046485)5.95609335
17neurotransmitter-gated ion channel clustering (GO:0072578)5.87802110
18G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.77851449
19urinary tract smooth muscle contraction (GO:0014848)5.74108078
20positive regulation of cAMP-mediated signaling (GO:0043950)5.67921612
21regulation of synapse maturation (GO:0090128)5.64698098
22regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.53501857
23detection of light stimulus (GO:0009583)5.50953268
24sensory perception of light stimulus (GO:0050953)5.50564292
25visual perception (GO:0007601)5.48884517
26detection of visible light (GO:0009584)5.47128667
27negative regulation of cytosolic calcium ion concentration (GO:0051481)5.45820022
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.44958403
29positive regulation of dendritic spine morphogenesis (GO:0061003)5.41835454
30negative regulation of cAMP-mediated signaling (GO:0043951)5.17971554
31protein neddylation (GO:0045116)5.17493654
32protein localization to synapse (GO:0035418)5.13985587
33GMP metabolic process (GO:0046037)5.12202764
34synaptic vesicle exocytosis (GO:0016079)5.10888517
35regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.10738181
36phototransduction (GO:0007602)4.94113792
37triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.91180529
38sarcomere organization (GO:0045214)4.87978247
39layer formation in cerebral cortex (GO:0021819)4.82599541
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78763895
41negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.77899217
42adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.74995470
43positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74212216
44phototransduction, visible light (GO:0007603)4.72755598
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.68049238
46peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.66123751
47cardiac muscle contraction (GO:0060048)4.63497352
48regulation of synaptic vesicle exocytosis (GO:2000300)4.61054019
49gamma-aminobutyric acid signaling pathway (GO:0007214)4.54673788
50negative regulation of heart rate (GO:0010459)4.54477899
51regulation of voltage-gated calcium channel activity (GO:1901385)4.50034107
52detection of calcium ion (GO:0005513)4.43370564
53opioid receptor signaling pathway (GO:0038003)4.33484911
54negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.32675488
55retina development in camera-type eye (GO:0060041)4.31676705
56cellular response to light stimulus (GO:0071482)4.30697465
57eye photoreceptor cell differentiation (GO:0001754)4.29498763
58photoreceptor cell differentiation (GO:0046530)4.29498763
59regulation of short-term neuronal synaptic plasticity (GO:0048172)4.24677298
60adenosine receptor signaling pathway (GO:0001973)4.23178102
61relaxation of cardiac muscle (GO:0055119)4.18641919
62synaptic vesicle endocytosis (GO:0048488)4.18414617
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.16216178
64synaptic vesicle maturation (GO:0016188)4.13843539
65adult feeding behavior (GO:0008343)4.12324155
66sodium ion export (GO:0071436)4.11238636
67potassium ion export (GO:0071435)4.11077414
68regulation of cell communication by electrical coupling (GO:0010649)4.10058430
69cell communication by electrical coupling (GO:0010644)4.06887475
70heart process (GO:0003015)4.05754172
71heart contraction (GO:0060047)4.05754172
72detection of external stimulus (GO:0009581)3.99866903
73detection of abiotic stimulus (GO:0009582)3.98055670
74regulation of actin filament-based movement (GO:1903115)3.96601850
75nonmotile primary cilium assembly (GO:0035058)3.96214673
76righting reflex (GO:0060013)3.94366960
77cardiac myofibril assembly (GO:0055003)3.91777323
78regulation of female receptivity (GO:0045924)3.91067680
79regulation of protein glycosylation (GO:0060049)3.88246626
80positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.83918626
81positive regulation of gastrulation (GO:2000543)3.82549018
82regulation of lipoprotein metabolic process (GO:0050746)3.82396658
83relaxation of muscle (GO:0090075)3.81021147
84cell communication involved in cardiac conduction (GO:0086065)3.79279308
85innervation (GO:0060384)3.78747701
86striatum development (GO:0021756)3.77162702
87regulation of platelet aggregation (GO:0090330)3.76352956
88response to caffeine (GO:0031000)3.75309230
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.75114139
90negative regulation of protein localization to cell surface (GO:2000009)3.74623376
91calcium-mediated signaling using intracellular calcium source (GO:0035584)3.74313816
92positive regulation of CREB transcription factor activity (GO:0032793)3.73493157
93blood coagulation, intrinsic pathway (GO:0007597)3.72507877
94cardiac muscle hypertrophy (GO:0003300)3.70363096
95actin-myosin filament sliding (GO:0033275)3.69665496
96muscle filament sliding (GO:0030049)3.69665496
97regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.68603988
98regulation of synaptic vesicle transport (GO:1902803)3.66401410
99regulation of relaxation of muscle (GO:1901077)3.65847336
100negative regulation of norepinephrine secretion (GO:0010700)3.65034859
101regulation of striated muscle contraction (GO:0006942)3.64635417
102regulation of integrin-mediated signaling pathway (GO:2001044)3.64111019
103regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.63207321
104regulation of cardiac muscle contraction (GO:0055117)3.62854894
105mating behavior (GO:0007617)3.60632636
106striated muscle contraction (GO:0006941)3.60182252
107regulation of calcium ion transmembrane transport (GO:1903169)3.54569038
108regulation of calcium ion transmembrane transporter activity (GO:1901019)3.54569038
109sarcoplasmic reticulum calcium ion transport (GO:0070296)3.53014929
110negative regulation of homotypic cell-cell adhesion (GO:0034111)3.52556043
111synaptic vesicle docking involved in exocytosis (GO:0016081)3.52055162
112regulation of cAMP-mediated signaling (GO:0043949)3.51849095
113neutrophil activation involved in immune response (GO:0002283)3.51147496
114myofibril assembly (GO:0030239)3.50945874
115response to histamine (GO:0034776)3.49773292
116glutamate secretion (GO:0014047)3.48192916
117striated muscle hypertrophy (GO:0014897)3.48069650
118regulation of heart rate (GO:0002027)3.47605189
119fat-soluble vitamin catabolic process (GO:0042363)3.47578947
120vitamin catabolic process (GO:0009111)3.47578947
121cellular response to epinephrine stimulus (GO:0071872)3.46734485
122positive regulation of TOR signaling (GO:0032008)3.44241852
123regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.43641385
124regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.43641385
125negative regulation of platelet activation (GO:0010544)3.41111047
126negative regulation of heart contraction (GO:0045822)3.39750303
127female mating behavior (GO:0060180)3.37534076
128negative regulation of nitric oxide biosynthetic process (GO:0045019)3.37219347
129sphingosine metabolic process (GO:0006670)3.32188040
130regulation of translational termination (GO:0006449)3.30484496
131membrane hyperpolarization (GO:0060081)3.30008884
132axon cargo transport (GO:0008088)3.29439016
133regulation of platelet activation (GO:0010543)3.28200878
134regulation of bile acid biosynthetic process (GO:0070857)3.25428081
135negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.25125291
136cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24008587
137regulation of the force of heart contraction (GO:0002026)3.22776192
138response to epinephrine (GO:0071871)3.21597460
139regulation of membrane repolarization (GO:0060306)3.21153844
140ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.17830287
141ventricular cardiac muscle cell action potential (GO:0086005)3.15539924
142glycerol ether metabolic process (GO:0006662)3.13248346
143positive regulation of membrane potential (GO:0045838)3.13167066
144heparan sulfate proteoglycan metabolic process (GO:0030201)3.12985579
145diol metabolic process (GO:0034311)3.12043353
146regulation of synaptic transmission, glutamatergic (GO:0051966)3.11223287
147phospholipid homeostasis (GO:0055091)3.10685900
148low-density lipoprotein particle remodeling (GO:0034374)3.09876568
149neuron fate determination (GO:0048664)3.09577150
150actin-mediated cell contraction (GO:0070252)3.09089473
151negative regulation of cation channel activity (GO:2001258)3.07069304
152positive regulation of guanylate cyclase activity (GO:0031284)3.06957327
153pyrimidine dimer repair (GO:0006290)3.05197916
154muscle hypertrophy (GO:0014896)3.04511598
155positive regulation of heart rate (GO:0010460)3.04487172
156regulation of cation channel activity (GO:2001257)3.04184694
157behavioral response to ethanol (GO:0048149)3.04136583
158regulation of neurotransmitter secretion (GO:0046928)3.02731301
159regulation of heart contraction (GO:0008016)3.01118467
160regulation of acrosome reaction (GO:0060046)3.00726299
161negative regulation of potassium ion transmembrane transport (GO:1901380)3.00355884
162substrate-independent telencephalic tangential migration (GO:0021826)2.99099554
163substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.99099554
164cardiac muscle tissue morphogenesis (GO:0055008)2.98403837
165negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.95977499
166synaptic vesicle transport (GO:0048489)2.94997692
167establishment of synaptic vesicle localization (GO:0097480)2.94997692
168glycolytic process (GO:0006096)2.94906219
169membrane repolarization (GO:0086009)2.94685914
170negative regulation of calcium ion transmembrane transport (GO:1903170)2.93774513
171negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.93774513
172negative regulation of glycoprotein biosynthetic process (GO:0010561)2.92973228
173positive regulation of muscle hypertrophy (GO:0014742)2.92862859
174positive regulation of cardiac muscle hypertrophy (GO:0010613)2.92862859
175positive regulation of circadian rhythm (GO:0042753)2.92860630
176positive regulation of endothelial cell differentiation (GO:0045603)2.91815176
177sphingoid metabolic process (GO:0046519)2.89444131
178neuron-neuron synaptic transmission (GO:0007270)2.89212018
179regulation of cGMP metabolic process (GO:0030823)2.88858783
180cerebellar Purkinje cell differentiation (GO:0021702)2.88506106
181membrane depolarization during action potential (GO:0086010)2.87841214
182adrenergic receptor signaling pathway (GO:0071875)2.87379372
183calcium ion import (GO:0070509)2.86536700
184regulation of neurotransmitter transport (GO:0051588)2.85794574
185relaxation of smooth muscle (GO:0044557)2.84872980
186positive regulation of dendritic spine development (GO:0060999)2.84521452
187long term synaptic depression (GO:0060292)2.83951364
188cellular sodium ion homeostasis (GO:0006883)2.83374684
189sulfation (GO:0051923)2.83304030
190long-term memory (GO:0007616)2.83031733
191sensory perception (GO:0007600)2.80665068
192detection of light stimulus involved in visual perception (GO:0050908)11.3531337
193detection of light stimulus involved in sensory perception (GO:0050962)11.3531337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.99516931
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.95901177
3EZH2_22144423_ChIP-Seq_EOC_Human3.73386855
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.59248947
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.18646054
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.17315047
7SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.93394988
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.89011875
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.70217085
10DROSHA_22980978_ChIP-Seq_HELA_Human2.50028175
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.41677345
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39020860
13AR_21572438_ChIP-Seq_LNCaP_Human2.38760747
14REST_21632747_ChIP-Seq_MESCs_Mouse2.34272695
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.30675144
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28084718
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.27347732
18SCL_19346495_ChIP-Seq_HPC-7_Human2.26558862
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26527306
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25888068
21HTT_18923047_ChIP-ChIP_STHdh_Human2.25557924
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24469854
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22908143
24VDR_22108803_ChIP-Seq_LS180_Human2.22551101
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.17879751
26TAF15_26573619_Chip-Seq_HEK293_Human2.16532729
27JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16316025
28EP300_21415370_ChIP-Seq_HL-1_Mouse2.10850979
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.08944494
30P53_22127205_ChIP-Seq_FIBROBLAST_Human2.07864528
31MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06958279
32RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04985262
33EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04985262
34CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.03177373
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.98798188
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.98600146
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93323096
38GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.86842204
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.85130621
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83458215
41GATA1_19941826_ChIP-Seq_K562_Human1.81935912
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.80805661
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.76707848
44GATA1_22025678_ChIP-Seq_K562_Human1.67898322
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65143308
46IGF1R_20145208_ChIP-Seq_DFB_Human1.64949922
47SMAD4_21799915_ChIP-Seq_A2780_Human1.61771681
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57746959
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.55974001
50GATA2_19941826_ChIP-Seq_K562_Human1.55620441
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.54197185
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53958654
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52738956
54FUS_26573619_Chip-Seq_HEK293_Human1.52589841
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49053456
56STAT3_23295773_ChIP-Seq_U87_Human1.47855547
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47583348
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47392481
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.47279829
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46841104
61P300_19829295_ChIP-Seq_ESCs_Human1.44551593
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44524886
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41872747
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40075782
65TBL1_22424771_ChIP-Seq_293T_Human1.39018632
66NANOG_19829295_ChIP-Seq_ESCs_Human1.38672350
67SOX2_19829295_ChIP-Seq_ESCs_Human1.38672350
68SMAD3_21741376_ChIP-Seq_HESCs_Human1.38368927
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34863519
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.34349450
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33417840
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33417840
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.32940975
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.31965044
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.31565931
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31503758
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.30230486
78TCF4_23295773_ChIP-Seq_U87_Human1.29538024
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29167135
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28810693
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28575464
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28545928
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28373555
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.27734355
85AR_19668381_ChIP-Seq_PC3_Human1.27560358
86CTCF_27219007_Chip-Seq_Bcells_Human1.26755477
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24605180
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24460883
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23849484
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23698688
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21479434
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.20739144
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19896137
94AR_25329375_ChIP-Seq_VCAP_Human1.19592605
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18316665
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18093548
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15778654
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15142903
99BCAT_22108803_ChIP-Seq_LS180_Human1.14017375
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13981311
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13919987
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13747969
103RUNX_20019798_ChIP-Seq_JUKART_Human1.12757797
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12108934
105CBX2_27304074_Chip-Seq_ESCs_Mouse1.09965080
106GATA1_19941827_ChIP-Seq_MEL86_Mouse1.09399841
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09132912
108MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08588971
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.07978561
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07156317
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06985811
112SOX2_21211035_ChIP-Seq_LN229_Gbm1.06983957
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06432967
114CBP_21632823_ChIP-Seq_H3396_Human1.06252043
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.06228447
116NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06139984
117YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05351170
118NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.03577325
119OCT1_27270436_Chip-Seq_PROSTATE_Human1.03425681
120RXR_22108803_ChIP-Seq_LS180_Human1.03261034
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02812265
122ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01948050
123OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01787954
124RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01235374
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01082208
126TP53_16413492_ChIP-PET_HCT116_Human1.00593718
127SMAD4_21741376_ChIP-Seq_HESCs_Human1.00315123
128ER_23166858_ChIP-Seq_MCF-7_Human1.00293676
129RNF2_27304074_Chip-Seq_NSC_Mouse1.00239108
130EGR1_19032775_ChIP-ChIP_M12_Human0.99467139
131RING1B_27294783_Chip-Seq_NPCs_Mouse0.99453646
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99282747
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98196569
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97551176
135KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97503680
136CDX2_22108803_ChIP-Seq_LS180_Human0.97298483
137NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97067880
138KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96850218
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96797592
140SPI1_23127762_ChIP-Seq_K562_Human0.96296571
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96226379
142ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96014846
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95480129
144OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94503221
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94157794
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93709478
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92749737
148MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92349952
149FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92229156
150SMAD4_21741376_ChIP-Seq_EPCs_Human0.92109975
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.91430036
152CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90897667
153TBX20_22328084_ChIP-Seq_HEART_Mouse0.90667315
154TBX20_22080862_ChIP-Seq_HEART_Mouse0.90667315
155AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90407859
156POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89991295
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89991295
158GATA3_21878914_ChIP-Seq_MCF-7_Human0.88725376
159ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88271398
160SMAD4_21741376_ChIP-Seq_ESCs_Human0.88047888
161LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87620709
162KDM2B_26808549_Chip-Seq_K562_Human0.87495102
163TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86884196
164SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86333166

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog8.37081759
2MP0003011_delayed_dark_adaptation6.21647770
3MP0006072_abnormal_retinal_apoptosis5.00104296
4MP0005253_abnormal_eye_physiology4.67672918
5MP0005464_abnormal_platelet_physiology4.58059182
6MP0002090_abnormal_vision4.39414977
7MP0001984_abnormal_olfaction3.99710576
8MP0002837_dystrophic_cardiac_calcinosis3.70318640
9MP0005195_abnormal_posterior_eye3.40065491
10MP0004510_myositis3.33074934
11MP0006292_abnormal_olfactory_placode3.19662259
12MP0009780_abnormal_chondrocyte_physiolo3.06895632
13MP0010386_abnormal_urinary_bladder3.05289297
14MP0004484_altered_response_of2.86990502
15MP0004130_abnormal_muscle_cell2.78815901
16MP0002638_abnormal_pupillary_reflex2.76996546
17MP0002972_abnormal_cardiac_muscle2.69266588
18MP0005385_cardiovascular_system_phenoty2.53678773
19MP0001544_abnormal_cardiovascular_syste2.53678773
20MP0001502_abnormal_circadian_rhythm2.52071104
21MP0004233_abnormal_muscle_weight2.50974511
22MP0009278_abnormal_bone_marrow2.46061978
23MP0003950_abnormal_plasma_membrane2.45697808
24MP0001324_abnormal_eye_pigmentation2.43021578
25MP0002229_neurodegeneration2.38701119
26MP0005499_abnormal_olfactory_system2.28256745
27MP0005394_taste/olfaction_phenotype2.28256745
28MP0002876_abnormal_thyroid_physiology2.26265540
29MP0005391_vision/eye_phenotype2.25274259
30MP0008789_abnormal_olfactory_epithelium2.18918709
31MP0006035_abnormal_mitochondrial_morpho2.14245359
32MP0006138_congestive_heart_failure2.13697204
33MP0003646_muscle_fatigue2.08494711
34MP0009046_muscle_twitch2.05181730
35MP0005330_cardiomyopathy2.00451709
36MP0000230_abnormal_systemic_arterial2.00328330
37MP0000343_altered_response_to2.00275893
38MP0002752_abnormal_somatic_nervous1.86364095
39MP0003137_abnormal_impulse_conducting1.82348796
40MP0000749_muscle_degeneration1.78413581
41MP0005423_abnormal_somatic_nervous1.76859738
42MP0003880_abnormal_central_pattern1.66879823
43MP0003828_pulmonary_edema1.66305439
44MP0005165_increased_susceptibility_to1.61978150
45MP0005646_abnormal_pituitary_gland1.60635100
46MP0004087_abnormal_muscle_fiber1.60358958
47MP0010630_abnormal_cardiac_muscle1.58834984
48MP0003635_abnormal_synaptic_transmissio1.58417399
49MP0001486_abnormal_startle_reflex1.56143080
50MP0010030_abnormal_orbit_morphology1.54513789
51MP0002882_abnormal_neuron_morphology1.52264302
52MP0001664_abnormal_digestion1.50246401
53MP0002272_abnormal_nervous_system1.49835636
54MP0002067_abnormal_sensory_capabilities1.49830715
55MP0005503_abnormal_tendon_morphology1.48855960
56MP0004859_abnormal_synaptic_plasticity1.47704581
57MP0001545_abnormal_hematopoietic_system1.46377305
58MP0005397_hematopoietic_system_phenotyp1.46377305
59MP0002234_abnormal_pharynx_morphology1.45705675
60MP0004036_abnormal_muscle_relaxation1.43058170
61MP0003638_abnormal_response/metabolism_1.40461336
62MP0003045_fibrosis1.40222086
63MP0003868_abnormal_feces_composition1.37661225
64MP0002734_abnormal_mechanical_nocicepti1.34896737
65MP0002184_abnormal_innervation1.33309491
66MP0008874_decreased_physiological_sensi1.33115140
67MP0009764_decreased_sensitivity_to1.32594584
68MP0002064_seizures1.32089158
69MP0005167_abnormal_blood-brain_barrier1.30102372
70MP0010368_abnormal_lymphatic_system1.28639982
71MP0004215_abnormal_myocardial_fiber1.28256729
72MP0003879_abnormal_hair_cell1.23257545
73MP0005666_abnormal_adipose_tissue1.22960020
74MP0002063_abnormal_learning/memory/cond1.22803494
75MP0002653_abnormal_ependyma_morphology1.20710158
76MP0002909_abnormal_adrenal_gland1.19628180
77MP0003724_increased_susceptibility_to1.18927154
78MP0003890_abnormal_embryonic-extraembry1.17711651
79MP0008569_lethality_at_weaning1.17340018
80MP0002733_abnormal_thermal_nociception1.17217202
81MP0006036_abnormal_mitochondrial_physio1.15315962
82MP0005248_abnormal_Harderian_gland1.13528678
83MP0002106_abnormal_muscle_physiology1.13231822
84MP0003787_abnormal_imprinting1.10895721
85MP0001968_abnormal_touch/_nociception1.08183300
86MP0001346_abnormal_lacrimal_gland1.05338268
87MP0005083_abnormal_biliary_tract1.02968439
88MP0009745_abnormal_behavioral_response1.02504729
89MP0005369_muscle_phenotype1.00144083
90MP0001529_abnormal_vocalization0.96898712
91MP0004270_analgesia0.96165818
92MP0002822_catalepsy0.95689865
93MP0005410_abnormal_fertilization0.93607266
94MP0002572_abnormal_emotion/affect_behav0.93092737
95MP0002332_abnormal_exercise_endurance0.91458854
96MP0000465_gastrointestinal_hemorrhage0.88504486
97MP0005360_urolithiasis0.87976949
98MP0003566_abnormal_cell_adhesion0.85678272
99MP0004084_abnormal_cardiac_muscle0.84067628
100MP0001188_hyperpigmentation0.82614645
101MP0002148_abnormal_hypersensitivity_rea0.82427354
102MP0001501_abnormal_sleep_pattern0.81805094
103MP0004742_abnormal_vestibular_system0.78851689
104MP0004782_abnormal_surfactant_physiolog0.78547350
105MP0000631_abnormal_neuroendocrine_gland0.76080387
106MP0005595_abnormal_vascular_smooth0.75751933
107MP0003183_abnormal_peptide_metabolism0.75642810
108MP0000358_abnormal_cell_content/0.75305819
109MP0005197_abnormal_uvea_morphology0.75173022
110MP0000569_abnormal_digit_pigmentation0.74062627
111MP0002736_abnormal_nociception_after0.73173168
112MP0003941_abnormal_skin_development0.73038720
113MP0008004_abnormal_stomach_pH0.72419870
114MP0005076_abnormal_cell_differentiation0.71815250
115MP0001851_eye_inflammation0.71598755
116MP0000015_abnormal_ear_pigmentation0.71580621
117MP0003634_abnormal_glial_cell0.71051567
118MP0009765_abnormal_xenobiotic_induced0.69931826
119MP0000249_abnormal_blood_vessel0.69499619
120MP0009333_abnormal_splenocyte_physiolog0.69121556
121MP0005670_abnormal_white_adipose0.68639652
122MP0004811_abnormal_neuron_physiology0.68288884
123MP0002128_abnormal_blood_circulation0.66473858
124MP0004019_abnormal_vitamin_homeostasis0.65379128
125MP0005620_abnormal_muscle_contractility0.65240282
126MP0005375_adipose_tissue_phenotype0.64439958
127MP0000751_myopathy0.64055313
128MP0006276_abnormal_autonomic_nervous0.63806805
129MP0000750_abnormal_muscle_regeneration0.63694016
130MP0002971_abnormal_brown_adipose0.63082602
131MP0004885_abnormal_endolymph0.62835158
132MP0004043_abnormal_pH_regulation0.62450412
133MP0010329_abnormal_lipoprotein_level0.62074125
134MP0009763_increased_sensitivity_to0.60800864
135MP0004924_abnormal_behavior0.58779814
136MP0005386_behavior/neurological_phenoty0.58779814
137MP0004085_abnormal_heartbeat0.58679217
138MP0000681_abnormal_thyroid_gland0.58582952
139MP0000678_abnormal_parathyroid_gland0.57155177
140MP0000955_abnormal_spinal_cord0.56750824
141MP0002066_abnormal_motor_capabilities/c0.56400403
142MP0002557_abnormal_social/conspecific_i0.55746632
143MP0008775_abnormal_heart_ventricle0.55015447
144MP0002127_abnormal_cardiovascular_syste0.54943474
145MP0002277_abnormal_respiratory_mucosa0.54791399
146MP0001764_abnormal_homeostasis0.54712908
147MP0005671_abnormal_response_to0.54459550
148MP0001765_abnormal_ion_homeostasis0.54392536
149MP0005334_abnormal_fat_pad0.54346521
150MP0002697_abnormal_eye_size0.53186473
151MP0002269_muscular_atrophy0.50774630
152MP0002118_abnormal_lipid_homeostasis0.50481650
153MP0004142_abnormal_muscle_tone0.50040621
154MP0001963_abnormal_hearing_physiology0.49865516
155MP0004147_increased_porphyrin_level0.48907045
156MP0003633_abnormal_nervous_system0.47729588
157MP0002152_abnormal_brain_morphology0.47683056
158MP0002089_abnormal_postnatal_growth/wei0.46570921
159MP0005220_abnormal_exocrine_pancreas0.44296213
160MP0001440_abnormal_grooming_behavior0.42829132
161MP0001293_anophthalmia0.42363065
162MP0008877_abnormal_DNA_methylation0.42357858
163MP0000534_abnormal_ureter_morphology0.41889380
164MP0001970_abnormal_pain_threshold0.41460983
165MP0001879_abnormal_lymphatic_vessel0.40696835
166MP0008872_abnormal_physiological_respon0.39755473
167MP0009697_abnormal_copulation0.39738934
168MP0005187_abnormal_penis_morphology0.38680891

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.90893532
2Abnormal rod and cone electroretinograms (HP:0008323)8.73686400
3Abnormality of macular pigmentation (HP:0008002)7.85401740
4Bony spicule pigmentary retinopathy (HP:0007737)7.76668616
5Absent rod-and cone-mediated responses on ERG (HP:0007688)7.46465607
6Thyroid-stimulating hormone excess (HP:0002925)7.07886427
7Scotoma (HP:0000575)6.98732151
8Severe visual impairment (HP:0001141)6.97776577
9Keratoconus (HP:0000563)6.85785201
10Increased corneal curvature (HP:0100692)6.85785201
11Bundle branch block (HP:0011710)6.77521989
12Prolonged bleeding time (HP:0003010)6.45687110
13Decreased central vision (HP:0007663)6.41369602
14Sudden death (HP:0001699)6.22207769
15Pendular nystagmus (HP:0012043)5.91175007
16Menorrhagia (HP:0000132)5.85424772
17Dyschromatopsia (HP:0007641)5.50393140
18Increased mean platelet volume (HP:0011877)5.38384626
19Abolished electroretinogram (ERG) (HP:0000550)5.35393013
20Chorioretinal atrophy (HP:0000533)5.29346611
21Pigmentary retinal degeneration (HP:0001146)5.14073320
22Hyperlipoproteinemia (HP:0010980)5.03411318
23Abnormal platelet volume (HP:0011876)4.95759858
24Attenuation of retinal blood vessels (HP:0007843)4.92072298
25Primary atrial arrhythmia (HP:0001692)4.75395841
26Supraventricular tachycardia (HP:0004755)4.59081938
27Hyporeflexia of lower limbs (HP:0002600)4.53818512
28Ventricular tachycardia (HP:0004756)4.49757344
29Petechiae (HP:0000967)4.44953498
30Supraventricular arrhythmia (HP:0005115)4.44800571
31Purpura (HP:0000979)4.40437573
32Epistaxis (HP:0000421)4.22966993
33Heart block (HP:0012722)4.19131747
34Ventricular fibrillation (HP:0001663)4.05965701
35Photophobia (HP:0000613)4.04718426
36Type II diabetes mellitus (HP:0005978)3.94647743
37Lipoatrophy (HP:0100578)3.94624877
38Abnormal atrioventricular conduction (HP:0005150)3.93759767
39Muscle fiber splitting (HP:0003555)3.86991075
40Constricted visual fields (HP:0001133)3.84291803
41Epileptic encephalopathy (HP:0200134)3.78778566
42Macular degeneration (HP:0000608)3.62820695
43Cerebellar dysplasia (HP:0007033)3.51327887
44Cone-rod dystrophy (HP:0000548)3.44919978
45Right ventricular cardiomyopathy (HP:0011663)3.43762861
46Absence seizures (HP:0002121)3.43621650
47Ventricular arrhythmia (HP:0004308)3.39407924
48Posterior subcapsular cataract (HP:0007787)3.32509153
49Retinitis pigmentosa (HP:0000510)3.26166406
50Distal lower limb muscle weakness (HP:0009053)3.19687034
51Dilated cardiomyopathy (HP:0001644)3.18875311
52Cholecystitis (HP:0001082)3.17691748
53Abnormal gallbladder physiology (HP:0012438)3.17691748
54Choroideremia (HP:0001139)3.13694244
55Febrile seizures (HP:0002373)3.08969295
56Gingival bleeding (HP:0000225)3.06312313
57Abnormality of the calf musculature (HP:0001430)3.00379993
58Vitreoretinal degeneration (HP:0000655)3.00045202
59Pancreatic islet-cell hyperplasia (HP:0004510)2.96707144
60Left ventricular hypertrophy (HP:0001712)2.95195113
61Septo-optic dysplasia (HP:0100842)2.92848117
62Asymmetric septal hypertrophy (HP:0001670)2.86386294
63Atrioventricular block (HP:0001678)2.85267204
64Palpitations (HP:0001962)2.84174940
65Hypoplasia of the fovea (HP:0007750)2.81414921
66Aplasia/Hypoplasia of the fovea (HP:0008060)2.81414921
67Impaired platelet aggregation (HP:0003540)2.79625833
68Abnormal platelet function (HP:0011869)2.79625833
69Poikilocytosis (HP:0004447)2.77402511
70Subaortic stenosis (HP:0001682)2.77233010
71Abnormality of the left ventricular outflow tract (HP:0011103)2.77233010
72Decreased electroretinogram (ERG) amplitude (HP:0000654)2.76893350
73Areflexia of lower limbs (HP:0002522)2.73688167
74Calf muscle hypertrophy (HP:0008981)2.71054413
75Dialeptic seizures (HP:0011146)2.65700676
76Partial agenesis of the corpus callosum (HP:0001338)2.58639377
77Abnormality of the fovea (HP:0000493)2.57076962
78Progressive cerebellar ataxia (HP:0002073)2.50929798
79Muscle hypertrophy of the lower extremities (HP:0008968)2.42123092
80Spontaneous hematomas (HP:0007420)2.39301158
81Congenital sensorineural hearing impairment (HP:0008527)2.36933219
82Acanthocytosis (HP:0001927)2.35594381
83Abnormality of the aortic arch (HP:0012303)2.33281683
84Bruising susceptibility (HP:0000978)2.31607331
85Agitation (HP:0000713)2.30652721
86Dysdiadochokinesis (HP:0002075)2.29416510
87Xanthomatosis (HP:0000991)2.28975064
88Distal lower limb amyotrophy (HP:0008944)2.24633727
89Abnormal pupillary function (HP:0007686)2.23742921
90EMG: myopathic abnormalities (HP:0003458)2.21178873
913-Methylglutaconic aciduria (HP:0003535)2.18553986
92Sudden cardiac death (HP:0001645)2.17838668
93EEG with generalized epileptiform discharges (HP:0011198)2.17144570
94Generalized tonic-clonic seizures (HP:0002069)2.15732419
95Testicular neoplasm (HP:0010788)2.14315633
96Optic disc pallor (HP:0000543)2.13748058
97Large for gestational age (HP:0001520)2.12794205
98Aplasia/Hypoplasia of the macula (HP:0008059)2.12629503
99Abnormality of the common coagulation pathway (HP:0010990)2.09735208
100Conjunctival telangiectasia (HP:0000524)2.09265110
101Epileptiform EEG discharges (HP:0011182)2.08086406
102Intestinal atresia (HP:0011100)2.05343098
103Gait imbalance (HP:0002141)2.04832701
104EMG: neuropathic changes (HP:0003445)2.01667026
105Congenital stationary night blindness (HP:0007642)14.6386520
106Nausea (HP:0002018)1.99969803
107Vertigo (HP:0002321)1.99351389
108Joint hemorrhage (HP:0005261)1.98305537
109Broad alveolar ridges (HP:0000187)1.97263238
110Tinnitus (HP:0000360)1.96974747
111Difficulty walking (HP:0002355)1.96699279
112Congenital primary aphakia (HP:0007707)1.96652056
113Albinism (HP:0001022)1.96050649
114Aplasia/Hypoplasia affecting the retina (HP:0008061)1.95695536
115Ragged-red muscle fibers (HP:0003200)1.92890163
116Abnormality of abdominal situs (HP:0011620)1.92276685
117Abdominal situs inversus (HP:0003363)1.92276685
118Thickened helices (HP:0000391)1.91105703
119True hermaphroditism (HP:0010459)1.90531471
120Hyperthyroidism (HP:0000836)1.89795636
121Increased variability in muscle fiber diameter (HP:0003557)1.89399064
122Heterotopia (HP:0002282)1.88914586
123Subcapsular cataract (HP:0000523)1.87195901
124Abnormality of skeletal muscle fiber size (HP:0012084)1.85592176
125Progressive visual loss (HP:0000529)1.85502251
126Atonic seizures (HP:0010819)1.84434958
127Widely spaced teeth (HP:0000687)1.82748397
128Palmoplantar keratoderma (HP:0000982)1.80288167
129Astigmatism (HP:0000483)1.79190488
130Abnormality of lateral ventricle (HP:0030047)1.77217734
131Prolonged QT interval (HP:0001657)1.76727086
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.76702801
133Myoglobinuria (HP:0002913)1.72986046
134Focal motor seizures (HP:0011153)1.72966431
135Nephrogenic diabetes insipidus (HP:0009806)1.72585663
136Dysmetric saccades (HP:0000641)1.72414863
137Severe Myopia (HP:0011003)1.72322580
138Increased density of long bones (HP:0006392)1.68919526
139Horizontal nystagmus (HP:0000666)1.68912777
140Abnormality of the vasculature of the conjunctiva (HP:0008054)1.68890122
141Mesangial abnormality (HP:0001966)1.67744664
142Abnormality of the heme biosynthetic pathway (HP:0010472)1.67630127
143Hypercortisolism (HP:0001578)1.67619014
144Abnormal auditory evoked potentials (HP:0006958)1.67165578
145Rimmed vacuoles (HP:0003805)1.65684064
146Oligodontia (HP:0000677)1.65666916
147Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.65212655
148Medial flaring of the eyebrow (HP:0010747)1.65051433
149Depression (HP:0000716)1.64974133
150Visual hallucinations (HP:0002367)1.63510254
151Wide nasal bridge (HP:0000431)1.61514602
152Truncal ataxia (HP:0002078)1.59558158
153Gaze-evoked nystagmus (HP:0000640)1.58849671
154Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.48592213
155Pancreatic fibrosis (HP:0100732)1.45707436
156Maternal diabetes (HP:0009800)1.43831894
157Abnormality of alanine metabolism (HP:0010916)1.43515458
158Hyperalaninemia (HP:0003348)1.43515458
159Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.43515458
160Vaginal atresia (HP:0000148)1.43502694
161Genital tract atresia (HP:0001827)1.42122002
162Poor coordination (HP:0002370)1.41944987
163Volvulus (HP:0002580)1.39825559
164Optic nerve hypoplasia (HP:0000609)1.39686282
165Mutism (HP:0002300)1.37790841
166Megalencephaly (HP:0001355)1.36972346
167Aplasia/Hypoplasia of the lens (HP:0008063)1.36948509
168Action tremor (HP:0002345)1.36794329
169Abnormal EKG (HP:0003115)1.36574153
170Myokymia (HP:0002411)1.36317598
171Retinal atrophy (HP:0001105)1.36142916
172Abnormality of the septum pellucidum (HP:0007375)1.35739561
173Focal seizures (HP:0007359)1.35702239
174Syncope (HP:0001279)1.32861212
175Absent septum pellucidum (HP:0001331)1.30108708
176Neoplasm of the heart (HP:0100544)1.29745865
177Atrial fibrillation (HP:0005110)1.26435755
178Exercise-induced myalgia (HP:0003738)1.25627787
179Optic atrophy (HP:0000648)1.23961700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK7.06230009
2ADRBK25.86352301
3NEK13.47395434
4TTN3.18397429
5NME13.12220509
6MST42.95711810
7STK38L2.82291428
8GRK12.73986723
9PAK62.73484027
10PRPF4B2.50506503
11FRK2.41273130
12RIPK12.22922765
13BMX2.22586036
14RIPK42.21958570
15OBSCN2.19495473
16PBK11.8054248
17STK381.97935892
18DMPK1.96828851
19ADRBK11.92500128
20MAP3K131.80489219
21PINK11.77950703
22MAPKAPK31.75129841
23ACVR1B1.72282364
24TEC1.68085730
25PTK2B1.59554351
26CDK31.58827849
27TAOK21.58816848
28PKN21.53699839
29FES1.48808368
30MINK11.48097793
31MARK11.46836557
32DYRK1A1.46243030
33BTK1.45154147
34MAP3K41.40237003
35PIK3CG1.39025517
36TAOK31.36794062
37PNCK1.36728371
38PRKD11.36505394
39PHKG21.30546358
40PHKG11.30546358
41MAP3K91.28694277
42STK41.27839630
43ERN11.27222304
44PLK21.24065887
45CAMK2D1.22482755
46SYK1.16331404
47IRAK31.12093738
48ILK1.09161289
49PRKD31.06364330
50LMTK21.04948804
51KSR21.04883464
52EIF2AK11.02411727
53CSF1R1.01459711
54NEK91.01369178
55PRKAA11.00721099
56MAP3K71.00425479
57MAP2K70.99514433
58GRK70.95417092
59EPHA40.94615850
60ITK0.90683278
61DAPK30.89520881
62ZAP700.88398283
63DYRK1B0.87791556
64INSRR0.87269118
65CAMK1D0.86920477
66STK30.86530511
67TRPM70.80778127
68PIK3CA0.79737228
69PRKD20.77200636
70MAP3K50.76894267
71MAP3K60.76419676
72PAK30.75710437
73ERBB30.75707565
74FER0.75522554
75CAMK1G0.72226323
76MUSK0.71482816
77MARK30.70296579
78PDK10.68703266
79ERBB20.68151475
80BMPR1B0.67411566
81CDK140.66836334
82GRK60.66381493
83MAPK110.65870751
84STK240.65827260
85ROCK10.65026278
86CLK10.61924408
87TGFBR10.60042468
88IRAK20.55895890
89SGK4940.54735884
90SGK2230.54735884
91CAMK10.53423917
92HCK0.53316747
93DYRK30.53263916
94MAP3K120.52588749
95MAPK70.51439634
96CDC42BPA0.51387232
97FLT30.50469284
98PKN10.50049026
99CHEK20.49207439
100CDK50.48823502
101PRKG20.48209172
102CDK150.47398937
103KSR10.46156308
104PRKCZ0.45971168
105PRKCB0.43818061
106CDK180.43347624
107CAMK2A0.43001535
108MAP2K40.41536700
109ARAF0.41215267
110IRAK10.39458209
111BRD40.39293174
112PRKCA0.38826731
113DAPK20.38673786
114CDK11A0.37759037
115PRKAA20.37709408
116NEK20.37308786
117PDPK10.36887998
118FGFR10.35486056
119PDK20.35443632
120MARK20.34862041
121PRKCE0.34079072
122RPS6KA30.33037532
123PAK10.32452897
124CAMKK10.32362480
125NTRK20.31741537
126TYRO30.31215672
127PRKCG0.30965850
128MAPK100.30865686
129PRKG10.30706395
130SIK20.30614134
131TIE10.30583116
132FGR0.30500215
133CAMK2G0.30161642
134PRKCD0.29501441
135EPHB20.29387176
136PRKACA0.29343039
137GSK3B0.28989673
138TLK10.28849931
139GRK50.28083026
140CSNK1D0.27607942
141FYN0.25940109
142HIPK20.25774563
143EPHA30.25552519
144ROCK20.25386936
145RET0.25326014
146PRKCH0.25323034
147BMPR20.24685117
148MAPK120.24394639
149PRKACG0.24384688
150LYN0.23927681
151MAPK90.23479975
152WNK30.22701419
153CAMK40.22678564
154IKBKB0.22453490
155TXK0.22439397
156STK390.21348733
157AKT30.20626649
158MAPK80.20230570
159TNK20.20103783
160MAP2K10.19597451
161MAPK140.18850152
162AKT20.18784162
163PTK60.18731926
164MAPK130.18682134
165TNIK0.18644480
166MAPK10.17547652

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047448.53720944
2Synaptic vesicle cycle_Homo sapiens_hsa047213.76579210
3GABAergic synapse_Homo sapiens_hsa047273.70758179
4Nicotine addiction_Homo sapiens_hsa050333.31299293
5Platelet activation_Homo sapiens_hsa046113.27679661
6Morphine addiction_Homo sapiens_hsa050323.14489209
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94004755
8Olfactory transduction_Homo sapiens_hsa047402.75062324
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.57391906
10Circadian rhythm_Homo sapiens_hsa047102.44789562
11Circadian entrainment_Homo sapiens_hsa047132.22782301
12Glutamatergic synapse_Homo sapiens_hsa047241.85618674
13Cholinergic synapse_Homo sapiens_hsa047251.84902180
14Insulin secretion_Homo sapiens_hsa049111.82405432
15Taste transduction_Homo sapiens_hsa047421.73179212
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.66736434
17Arachidonic acid metabolism_Homo sapiens_hsa005901.62348384
18Fructose and mannose metabolism_Homo sapiens_hsa000511.60863933
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.60301779
20Renin secretion_Homo sapiens_hsa049241.57143395
21ECM-receptor interaction_Homo sapiens_hsa045121.55413973
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.51435506
23Serotonergic synapse_Homo sapiens_hsa047261.49658524
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48198022
25Dopaminergic synapse_Homo sapiens_hsa047281.44771727
26Salivary secretion_Homo sapiens_hsa049701.38192184
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37242411
28Linoleic acid metabolism_Homo sapiens_hsa005911.34074048
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33382940
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31489773
31Parkinsons disease_Homo sapiens_hsa050121.25504670
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25226007
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.24250674
34Biosynthesis of amino acids_Homo sapiens_hsa012301.19357994
35Oxytocin signaling pathway_Homo sapiens_hsa049211.18039726
36Cardiac muscle contraction_Homo sapiens_hsa042601.16905634
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16882551
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16736207
39Dorso-ventral axis formation_Homo sapiens_hsa043201.16023781
40PPAR signaling pathway_Homo sapiens_hsa033201.12299834
41Ovarian steroidogenesis_Homo sapiens_hsa049131.12281314
42Type II diabetes mellitus_Homo sapiens_hsa049301.09425686
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04784181
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.04233923
45Dilated cardiomyopathy_Homo sapiens_hsa054141.03909522
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01566024
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00469985
48Collecting duct acid secretion_Homo sapiens_hsa049660.93710133
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92598352
50Sphingolipid metabolism_Homo sapiens_hsa006000.92100697
51Fatty acid degradation_Homo sapiens_hsa000710.91559131
52Retinol metabolism_Homo sapiens_hsa008300.91280686
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89945281
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89922777
55Fatty acid elongation_Homo sapiens_hsa000620.88545685
56mTOR signaling pathway_Homo sapiens_hsa041500.87522651
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87415025
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86557307
59Inositol phosphate metabolism_Homo sapiens_hsa005620.82192845
60Alzheimers disease_Homo sapiens_hsa050100.79146447
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75302796
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74954013
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74513004
64Calcium signaling pathway_Homo sapiens_hsa040200.70373965
65Alcoholism_Homo sapiens_hsa050340.70001287
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69538210
67Complement and coagulation cascades_Homo sapiens_hsa046100.68580728
68Oxidative phosphorylation_Homo sapiens_hsa001900.64421051
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64095566
70cAMP signaling pathway_Homo sapiens_hsa040240.63511304
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.62513288
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62277293
73Starch and sucrose metabolism_Homo sapiens_hsa005000.60630111
74Butanoate metabolism_Homo sapiens_hsa006500.60494904
75Focal adhesion_Homo sapiens_hsa045100.59236379
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58020991
77Arginine and proline metabolism_Homo sapiens_hsa003300.57843444
78Pentose phosphate pathway_Homo sapiens_hsa000300.55780441
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55495231
80Gap junction_Homo sapiens_hsa045400.54859640
81Pancreatic secretion_Homo sapiens_hsa049720.54232794
82Hematopoietic cell lineage_Homo sapiens_hsa046400.53690557
83Colorectal cancer_Homo sapiens_hsa052100.52603193
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51846449
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.51229709
86HIF-1 signaling pathway_Homo sapiens_hsa040660.51053026
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50427304
88Glutathione metabolism_Homo sapiens_hsa004800.49164981
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.47974564
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45966285
91Gastric acid secretion_Homo sapiens_hsa049710.45045820
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44822528
93Carbon metabolism_Homo sapiens_hsa012000.43335066
94Galactose metabolism_Homo sapiens_hsa000520.43158838
95ABC transporters_Homo sapiens_hsa020100.43072847
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42495852
97Tryptophan metabolism_Homo sapiens_hsa003800.41219588
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39419249
99Propanoate metabolism_Homo sapiens_hsa006400.39166260
100GnRH signaling pathway_Homo sapiens_hsa049120.39007766
101Huntingtons disease_Homo sapiens_hsa050160.38146825
102Sulfur relay system_Homo sapiens_hsa041220.37112817
103Regulation of autophagy_Homo sapiens_hsa041400.36836511
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35510088
105Choline metabolism in cancer_Homo sapiens_hsa052310.35411467
106Cocaine addiction_Homo sapiens_hsa050300.34408352
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34349277
108Arginine biosynthesis_Homo sapiens_hsa002200.32704102
109Systemic lupus erythematosus_Homo sapiens_hsa053220.32421738
110Renal cell carcinoma_Homo sapiens_hsa052110.32245614
111beta-Alanine metabolism_Homo sapiens_hsa004100.32190100
112Vibrio cholerae infection_Homo sapiens_hsa051100.32168975
113Glycerolipid metabolism_Homo sapiens_hsa005610.31672312
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31365505
115Bile secretion_Homo sapiens_hsa049760.30514838
116Glioma_Homo sapiens_hsa052140.29542559
117AMPK signaling pathway_Homo sapiens_hsa041520.29343264
118Fatty acid metabolism_Homo sapiens_hsa012120.28531073
119Phenylalanine metabolism_Homo sapiens_hsa003600.28465140
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28121704
121Ras signaling pathway_Homo sapiens_hsa040140.28059664
122Chemokine signaling pathway_Homo sapiens_hsa040620.27062568
123Long-term depression_Homo sapiens_hsa047300.27043324
124Glucagon signaling pathway_Homo sapiens_hsa049220.26891343
125Endometrial cancer_Homo sapiens_hsa052130.26773500
126Long-term potentiation_Homo sapiens_hsa047200.26708103
127Purine metabolism_Homo sapiens_hsa002300.26581300
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.26056121
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25691721
130ErbB signaling pathway_Homo sapiens_hsa040120.22379869
131MAPK signaling pathway_Homo sapiens_hsa040100.22128513
132Mineral absorption_Homo sapiens_hsa049780.22068663
133Melanoma_Homo sapiens_hsa052180.20333126
134Amphetamine addiction_Homo sapiens_hsa050310.20241272
135VEGF signaling pathway_Homo sapiens_hsa043700.19487381
136Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19275085
137Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19200940
138Pyruvate metabolism_Homo sapiens_hsa006200.18016599
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16951991
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16667939
141Pancreatic cancer_Homo sapiens_hsa052120.14859252
142Estrogen signaling pathway_Homo sapiens_hsa049150.13417203
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13396983
144Nitrogen metabolism_Homo sapiens_hsa009100.11158758
145Axon guidance_Homo sapiens_hsa043600.08676760

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