

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | retinal rod cell development (GO:0046548) | 9.91228656 |
| 2 | rhodopsin mediated signaling pathway (GO:0016056) | 9.01319949 |
| 3 | retinal cone cell development (GO:0046549) | 7.90503385 |
| 4 | regulation of rhodopsin mediated signaling pathway (GO:0022400) | 7.90459575 |
| 5 | cellular potassium ion homeostasis (GO:0030007) | 7.60044426 |
| 6 | positive regulation of synapse maturation (GO:0090129) | 7.44854397 |
| 7 | photoreceptor cell development (GO:0042461) | 7.12665400 |
| 8 | response to pheromone (GO:0019236) | 6.90429505 |
| 9 | eye photoreceptor cell development (GO:0042462) | 6.87807530 |
| 10 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 6.85502412 |
| 11 | thrombin receptor signaling pathway (GO:0070493) | 6.69567395 |
| 12 | photoreceptor cell maintenance (GO:0045494) | 6.51067867 |
| 13 | protein-chromophore linkage (GO:0018298) | 6.49762614 |
| 14 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 6.26519831 |
| 15 | potassium ion homeostasis (GO:0055075) | 6.02548876 |
| 16 | ether lipid metabolic process (GO:0046485) | 5.95609335 |
| 17 | neurotransmitter-gated ion channel clustering (GO:0072578) | 5.87802110 |
| 18 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 5.77851449 |
| 19 | urinary tract smooth muscle contraction (GO:0014848) | 5.74108078 |
| 20 | positive regulation of cAMP-mediated signaling (GO:0043950) | 5.67921612 |
| 21 | regulation of synapse maturation (GO:0090128) | 5.64698098 |
| 22 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 5.53501857 |
| 23 | detection of light stimulus (GO:0009583) | 5.50953268 |
| 24 | sensory perception of light stimulus (GO:0050953) | 5.50564292 |
| 25 | visual perception (GO:0007601) | 5.48884517 |
| 26 | detection of visible light (GO:0009584) | 5.47128667 |
| 27 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 5.45820022 |
| 28 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 5.44958403 |
| 29 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 5.41835454 |
| 30 | negative regulation of cAMP-mediated signaling (GO:0043951) | 5.17971554 |
| 31 | protein neddylation (GO:0045116) | 5.17493654 |
| 32 | protein localization to synapse (GO:0035418) | 5.13985587 |
| 33 | GMP metabolic process (GO:0046037) | 5.12202764 |
| 34 | synaptic vesicle exocytosis (GO:0016079) | 5.10888517 |
| 35 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 5.10738181 |
| 36 | phototransduction (GO:0007602) | 4.94113792 |
| 37 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 4.91180529 |
| 38 | sarcomere organization (GO:0045214) | 4.87978247 |
| 39 | layer formation in cerebral cortex (GO:0021819) | 4.82599541 |
| 40 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.78763895 |
| 41 | negative regulation of calcium ion-dependent exocytosis (GO:0045955) | 4.77899217 |
| 42 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 4.74995470 |
| 43 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.74212216 |
| 44 | phototransduction, visible light (GO:0007603) | 4.72755598 |
| 45 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 4.68049238 |
| 46 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800) | 4.66123751 |
| 47 | cardiac muscle contraction (GO:0060048) | 4.63497352 |
| 48 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.61054019 |
| 49 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 4.54673788 |
| 50 | negative regulation of heart rate (GO:0010459) | 4.54477899 |
| 51 | regulation of voltage-gated calcium channel activity (GO:1901385) | 4.50034107 |
| 52 | detection of calcium ion (GO:0005513) | 4.43370564 |
| 53 | opioid receptor signaling pathway (GO:0038003) | 4.33484911 |
| 54 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 4.32675488 |
| 55 | retina development in camera-type eye (GO:0060041) | 4.31676705 |
| 56 | cellular response to light stimulus (GO:0071482) | 4.30697465 |
| 57 | eye photoreceptor cell differentiation (GO:0001754) | 4.29498763 |
| 58 | photoreceptor cell differentiation (GO:0046530) | 4.29498763 |
| 59 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.24677298 |
| 60 | adenosine receptor signaling pathway (GO:0001973) | 4.23178102 |
| 61 | relaxation of cardiac muscle (GO:0055119) | 4.18641919 |
| 62 | synaptic vesicle endocytosis (GO:0048488) | 4.18414617 |
| 63 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.16216178 |
| 64 | synaptic vesicle maturation (GO:0016188) | 4.13843539 |
| 65 | adult feeding behavior (GO:0008343) | 4.12324155 |
| 66 | sodium ion export (GO:0071436) | 4.11238636 |
| 67 | potassium ion export (GO:0071435) | 4.11077414 |
| 68 | regulation of cell communication by electrical coupling (GO:0010649) | 4.10058430 |
| 69 | cell communication by electrical coupling (GO:0010644) | 4.06887475 |
| 70 | heart process (GO:0003015) | 4.05754172 |
| 71 | heart contraction (GO:0060047) | 4.05754172 |
| 72 | detection of external stimulus (GO:0009581) | 3.99866903 |
| 73 | detection of abiotic stimulus (GO:0009582) | 3.98055670 |
| 74 | regulation of actin filament-based movement (GO:1903115) | 3.96601850 |
| 75 | nonmotile primary cilium assembly (GO:0035058) | 3.96214673 |
| 76 | righting reflex (GO:0060013) | 3.94366960 |
| 77 | cardiac myofibril assembly (GO:0055003) | 3.91777323 |
| 78 | regulation of female receptivity (GO:0045924) | 3.91067680 |
| 79 | regulation of protein glycosylation (GO:0060049) | 3.88246626 |
| 80 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.83918626 |
| 81 | positive regulation of gastrulation (GO:2000543) | 3.82549018 |
| 82 | regulation of lipoprotein metabolic process (GO:0050746) | 3.82396658 |
| 83 | relaxation of muscle (GO:0090075) | 3.81021147 |
| 84 | cell communication involved in cardiac conduction (GO:0086065) | 3.79279308 |
| 85 | innervation (GO:0060384) | 3.78747701 |
| 86 | striatum development (GO:0021756) | 3.77162702 |
| 87 | regulation of platelet aggregation (GO:0090330) | 3.76352956 |
| 88 | response to caffeine (GO:0031000) | 3.75309230 |
| 89 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.75114139 |
| 90 | negative regulation of protein localization to cell surface (GO:2000009) | 3.74623376 |
| 91 | calcium-mediated signaling using intracellular calcium source (GO:0035584) | 3.74313816 |
| 92 | positive regulation of CREB transcription factor activity (GO:0032793) | 3.73493157 |
| 93 | blood coagulation, intrinsic pathway (GO:0007597) | 3.72507877 |
| 94 | cardiac muscle hypertrophy (GO:0003300) | 3.70363096 |
| 95 | actin-myosin filament sliding (GO:0033275) | 3.69665496 |
| 96 | muscle filament sliding (GO:0030049) | 3.69665496 |
| 97 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.68603988 |
| 98 | regulation of synaptic vesicle transport (GO:1902803) | 3.66401410 |
| 99 | regulation of relaxation of muscle (GO:1901077) | 3.65847336 |
| 100 | negative regulation of norepinephrine secretion (GO:0010700) | 3.65034859 |
| 101 | regulation of striated muscle contraction (GO:0006942) | 3.64635417 |
| 102 | regulation of integrin-mediated signaling pathway (GO:2001044) | 3.64111019 |
| 103 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.63207321 |
| 104 | regulation of cardiac muscle contraction (GO:0055117) | 3.62854894 |
| 105 | mating behavior (GO:0007617) | 3.60632636 |
| 106 | striated muscle contraction (GO:0006941) | 3.60182252 |
| 107 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.54569038 |
| 108 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.54569038 |
| 109 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 3.53014929 |
| 110 | negative regulation of homotypic cell-cell adhesion (GO:0034111) | 3.52556043 |
| 111 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.52055162 |
| 112 | regulation of cAMP-mediated signaling (GO:0043949) | 3.51849095 |
| 113 | neutrophil activation involved in immune response (GO:0002283) | 3.51147496 |
| 114 | myofibril assembly (GO:0030239) | 3.50945874 |
| 115 | response to histamine (GO:0034776) | 3.49773292 |
| 116 | glutamate secretion (GO:0014047) | 3.48192916 |
| 117 | striated muscle hypertrophy (GO:0014897) | 3.48069650 |
| 118 | regulation of heart rate (GO:0002027) | 3.47605189 |
| 119 | fat-soluble vitamin catabolic process (GO:0042363) | 3.47578947 |
| 120 | vitamin catabolic process (GO:0009111) | 3.47578947 |
| 121 | cellular response to epinephrine stimulus (GO:0071872) | 3.46734485 |
| 122 | positive regulation of TOR signaling (GO:0032008) | 3.44241852 |
| 123 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 3.43641385 |
| 124 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 3.43641385 |
| 125 | negative regulation of platelet activation (GO:0010544) | 3.41111047 |
| 126 | negative regulation of heart contraction (GO:0045822) | 3.39750303 |
| 127 | female mating behavior (GO:0060180) | 3.37534076 |
| 128 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 3.37219347 |
| 129 | sphingosine metabolic process (GO:0006670) | 3.32188040 |
| 130 | regulation of translational termination (GO:0006449) | 3.30484496 |
| 131 | membrane hyperpolarization (GO:0060081) | 3.30008884 |
| 132 | axon cargo transport (GO:0008088) | 3.29439016 |
| 133 | regulation of platelet activation (GO:0010543) | 3.28200878 |
| 134 | regulation of bile acid biosynthetic process (GO:0070857) | 3.25428081 |
| 135 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 3.25125291 |
| 136 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.24008587 |
| 137 | regulation of the force of heart contraction (GO:0002026) | 3.22776192 |
| 138 | response to epinephrine (GO:0071871) | 3.21597460 |
| 139 | regulation of membrane repolarization (GO:0060306) | 3.21153844 |
| 140 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 3.17830287 |
| 141 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.15539924 |
| 142 | glycerol ether metabolic process (GO:0006662) | 3.13248346 |
| 143 | positive regulation of membrane potential (GO:0045838) | 3.13167066 |
| 144 | heparan sulfate proteoglycan metabolic process (GO:0030201) | 3.12985579 |
| 145 | diol metabolic process (GO:0034311) | 3.12043353 |
| 146 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.11223287 |
| 147 | phospholipid homeostasis (GO:0055091) | 3.10685900 |
| 148 | low-density lipoprotein particle remodeling (GO:0034374) | 3.09876568 |
| 149 | neuron fate determination (GO:0048664) | 3.09577150 |
| 150 | actin-mediated cell contraction (GO:0070252) | 3.09089473 |
| 151 | negative regulation of cation channel activity (GO:2001258) | 3.07069304 |
| 152 | positive regulation of guanylate cyclase activity (GO:0031284) | 3.06957327 |
| 153 | pyrimidine dimer repair (GO:0006290) | 3.05197916 |
| 154 | muscle hypertrophy (GO:0014896) | 3.04511598 |
| 155 | positive regulation of heart rate (GO:0010460) | 3.04487172 |
| 156 | regulation of cation channel activity (GO:2001257) | 3.04184694 |
| 157 | behavioral response to ethanol (GO:0048149) | 3.04136583 |
| 158 | regulation of neurotransmitter secretion (GO:0046928) | 3.02731301 |
| 159 | regulation of heart contraction (GO:0008016) | 3.01118467 |
| 160 | regulation of acrosome reaction (GO:0060046) | 3.00726299 |
| 161 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.00355884 |
| 162 | substrate-independent telencephalic tangential migration (GO:0021826) | 2.99099554 |
| 163 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 2.99099554 |
| 164 | cardiac muscle tissue morphogenesis (GO:0055008) | 2.98403837 |
| 165 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 2.95977499 |
| 166 | synaptic vesicle transport (GO:0048489) | 2.94997692 |
| 167 | establishment of synaptic vesicle localization (GO:0097480) | 2.94997692 |
| 168 | glycolytic process (GO:0006096) | 2.94906219 |
| 169 | membrane repolarization (GO:0086009) | 2.94685914 |
| 170 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 2.93774513 |
| 171 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 2.93774513 |
| 172 | negative regulation of glycoprotein biosynthetic process (GO:0010561) | 2.92973228 |
| 173 | positive regulation of muscle hypertrophy (GO:0014742) | 2.92862859 |
| 174 | positive regulation of cardiac muscle hypertrophy (GO:0010613) | 2.92862859 |
| 175 | positive regulation of circadian rhythm (GO:0042753) | 2.92860630 |
| 176 | positive regulation of endothelial cell differentiation (GO:0045603) | 2.91815176 |
| 177 | sphingoid metabolic process (GO:0046519) | 2.89444131 |
| 178 | neuron-neuron synaptic transmission (GO:0007270) | 2.89212018 |
| 179 | regulation of cGMP metabolic process (GO:0030823) | 2.88858783 |
| 180 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.88506106 |
| 181 | membrane depolarization during action potential (GO:0086010) | 2.87841214 |
| 182 | adrenergic receptor signaling pathway (GO:0071875) | 2.87379372 |
| 183 | calcium ion import (GO:0070509) | 2.86536700 |
| 184 | regulation of neurotransmitter transport (GO:0051588) | 2.85794574 |
| 185 | relaxation of smooth muscle (GO:0044557) | 2.84872980 |
| 186 | positive regulation of dendritic spine development (GO:0060999) | 2.84521452 |
| 187 | long term synaptic depression (GO:0060292) | 2.83951364 |
| 188 | cellular sodium ion homeostasis (GO:0006883) | 2.83374684 |
| 189 | sulfation (GO:0051923) | 2.83304030 |
| 190 | long-term memory (GO:0007616) | 2.83031733 |
| 191 | sensory perception (GO:0007600) | 2.80665068 |
| 192 | detection of light stimulus involved in visual perception (GO:0050908) | 11.3531337 |
| 193 | detection of light stimulus involved in sensory perception (GO:0050962) | 11.3531337 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.99516931 |
| 2 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 3.95901177 |
| 3 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.73386855 |
| 4 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.59248947 |
| 5 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 3.18646054 |
| 6 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 3.17315047 |
| 7 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 2.93394988 |
| 8 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.89011875 |
| 9 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.70217085 |
| 10 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.50028175 |
| 11 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.41677345 |
| 12 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.39020860 |
| 13 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.38760747 |
| 14 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.34272695 |
| 15 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 2.30675144 |
| 16 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.28084718 |
| 17 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.27347732 |
| 18 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.26558862 |
| 19 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.26527306 |
| 20 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.25888068 |
| 21 | HTT_18923047_ChIP-ChIP_STHdh_Human | 2.25557924 |
| 22 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.24469854 |
| 23 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.22908143 |
| 24 | VDR_22108803_ChIP-Seq_LS180_Human | 2.22551101 |
| 25 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.17879751 |
| 26 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.16532729 |
| 27 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.16316025 |
| 28 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 2.10850979 |
| 29 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.08944494 |
| 30 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 2.07864528 |
| 31 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.06958279 |
| 32 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.04985262 |
| 33 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.04985262 |
| 34 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 2.03177373 |
| 35 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.98798188 |
| 36 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.98600146 |
| 37 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.93323096 |
| 38 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.86842204 |
| 39 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.85130621 |
| 40 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.83458215 |
| 41 | GATA1_19941826_ChIP-Seq_K562_Human | 1.81935912 |
| 42 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.80805661 |
| 43 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.76707848 |
| 44 | GATA1_22025678_ChIP-Seq_K562_Human | 1.67898322 |
| 45 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.65143308 |
| 46 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.64949922 |
| 47 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.61771681 |
| 48 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.57746959 |
| 49 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.55974001 |
| 50 | GATA2_19941826_ChIP-Seq_K562_Human | 1.55620441 |
| 51 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.54197185 |
| 52 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.53958654 |
| 53 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.52738956 |
| 54 | FUS_26573619_Chip-Seq_HEK293_Human | 1.52589841 |
| 55 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.49053456 |
| 56 | STAT3_23295773_ChIP-Seq_U87_Human | 1.47855547 |
| 57 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.47583348 |
| 58 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.47392481 |
| 59 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.47279829 |
| 60 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.46841104 |
| 61 | P300_19829295_ChIP-Seq_ESCs_Human | 1.44551593 |
| 62 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.44524886 |
| 63 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.41872747 |
| 64 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.40075782 |
| 65 | TBL1_22424771_ChIP-Seq_293T_Human | 1.39018632 |
| 66 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.38672350 |
| 67 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.38672350 |
| 68 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.38368927 |
| 69 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.34863519 |
| 70 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.34349450 |
| 71 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.33417840 |
| 72 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.33417840 |
| 73 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.32940975 |
| 74 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.31965044 |
| 75 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.31565931 |
| 76 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.31503758 |
| 77 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.30230486 |
| 78 | TCF4_23295773_ChIP-Seq_U87_Human | 1.29538024 |
| 79 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.29167135 |
| 80 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.28810693 |
| 81 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.28575464 |
| 82 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.28545928 |
| 83 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.28373555 |
| 84 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.27734355 |
| 85 | AR_19668381_ChIP-Seq_PC3_Human | 1.27560358 |
| 86 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.26755477 |
| 87 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.24605180 |
| 88 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.24460883 |
| 89 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.23849484 |
| 90 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.23698688 |
| 91 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.21479434 |
| 92 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.20739144 |
| 93 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.19896137 |
| 94 | AR_25329375_ChIP-Seq_VCAP_Human | 1.19592605 |
| 95 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.18316665 |
| 96 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.18093548 |
| 97 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.15778654 |
| 98 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.15142903 |
| 99 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.14017375 |
| 100 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.13981311 |
| 101 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.13919987 |
| 102 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.13747969 |
| 103 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.12757797 |
| 104 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.12108934 |
| 105 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.09965080 |
| 106 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 1.09399841 |
| 107 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.09132912 |
| 108 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.08588971 |
| 109 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.07978561 |
| 110 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.07156317 |
| 111 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.06985811 |
| 112 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.06983957 |
| 113 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.06432967 |
| 114 | CBP_21632823_ChIP-Seq_H3396_Human | 1.06252043 |
| 115 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.06228447 |
| 116 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.06139984 |
| 117 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.05351170 |
| 118 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 1.03577325 |
| 119 | OCT1_27270436_Chip-Seq_PROSTATE_Human | 1.03425681 |
| 120 | RXR_22108803_ChIP-Seq_LS180_Human | 1.03261034 |
| 121 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.02812265 |
| 122 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.01948050 |
| 123 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.01787954 |
| 124 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.01235374 |
| 125 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.01082208 |
| 126 | TP53_16413492_ChIP-PET_HCT116_Human | 1.00593718 |
| 127 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.00315123 |
| 128 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.00293676 |
| 129 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.00239108 |
| 130 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.99467139 |
| 131 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.99453646 |
| 132 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.99282747 |
| 133 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.98196569 |
| 134 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.97551176 |
| 135 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.97503680 |
| 136 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.97298483 |
| 137 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 0.97067880 |
| 138 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 0.96850218 |
| 139 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.96797592 |
| 140 | SPI1_23127762_ChIP-Seq_K562_Human | 0.96296571 |
| 141 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.96226379 |
| 142 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 0.96014846 |
| 143 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.95480129 |
| 144 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.94503221 |
| 145 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.94157794 |
| 146 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.93709478 |
| 147 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.92749737 |
| 148 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 0.92349952 |
| 149 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.92229156 |
| 150 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.92109975 |
| 151 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.91430036 |
| 152 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.90897667 |
| 153 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.90667315 |
| 154 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.90667315 |
| 155 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.90407859 |
| 156 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.89991295 |
| 157 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.89991295 |
| 158 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.88725376 |
| 159 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.88271398 |
| 160 | SMAD4_21741376_ChIP-Seq_ESCs_Human | 0.88047888 |
| 161 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.87620709 |
| 162 | KDM2B_26808549_Chip-Seq_K562_Human | 0.87495102 |
| 163 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.86884196 |
| 164 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.86333166 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005551_abnormal_eye_electrophysiolog | 8.37081759 |
| 2 | MP0003011_delayed_dark_adaptation | 6.21647770 |
| 3 | MP0006072_abnormal_retinal_apoptosis | 5.00104296 |
| 4 | MP0005253_abnormal_eye_physiology | 4.67672918 |
| 5 | MP0005464_abnormal_platelet_physiology | 4.58059182 |
| 6 | MP0002090_abnormal_vision | 4.39414977 |
| 7 | MP0001984_abnormal_olfaction | 3.99710576 |
| 8 | MP0002837_dystrophic_cardiac_calcinosis | 3.70318640 |
| 9 | MP0005195_abnormal_posterior_eye | 3.40065491 |
| 10 | MP0004510_myositis | 3.33074934 |
| 11 | MP0006292_abnormal_olfactory_placode | 3.19662259 |
| 12 | MP0009780_abnormal_chondrocyte_physiolo | 3.06895632 |
| 13 | MP0010386_abnormal_urinary_bladder | 3.05289297 |
| 14 | MP0004484_altered_response_of | 2.86990502 |
| 15 | MP0004130_abnormal_muscle_cell | 2.78815901 |
| 16 | MP0002638_abnormal_pupillary_reflex | 2.76996546 |
| 17 | MP0002972_abnormal_cardiac_muscle | 2.69266588 |
| 18 | MP0005385_cardiovascular_system_phenoty | 2.53678773 |
| 19 | MP0001544_abnormal_cardiovascular_syste | 2.53678773 |
| 20 | MP0001502_abnormal_circadian_rhythm | 2.52071104 |
| 21 | MP0004233_abnormal_muscle_weight | 2.50974511 |
| 22 | MP0009278_abnormal_bone_marrow | 2.46061978 |
| 23 | MP0003950_abnormal_plasma_membrane | 2.45697808 |
| 24 | MP0001324_abnormal_eye_pigmentation | 2.43021578 |
| 25 | MP0002229_neurodegeneration | 2.38701119 |
| 26 | MP0005499_abnormal_olfactory_system | 2.28256745 |
| 27 | MP0005394_taste/olfaction_phenotype | 2.28256745 |
| 28 | MP0002876_abnormal_thyroid_physiology | 2.26265540 |
| 29 | MP0005391_vision/eye_phenotype | 2.25274259 |
| 30 | MP0008789_abnormal_olfactory_epithelium | 2.18918709 |
| 31 | MP0006035_abnormal_mitochondrial_morpho | 2.14245359 |
| 32 | MP0006138_congestive_heart_failure | 2.13697204 |
| 33 | MP0003646_muscle_fatigue | 2.08494711 |
| 34 | MP0009046_muscle_twitch | 2.05181730 |
| 35 | MP0005330_cardiomyopathy | 2.00451709 |
| 36 | MP0000230_abnormal_systemic_arterial | 2.00328330 |
| 37 | MP0000343_altered_response_to | 2.00275893 |
| 38 | MP0002752_abnormal_somatic_nervous | 1.86364095 |
| 39 | MP0003137_abnormal_impulse_conducting | 1.82348796 |
| 40 | MP0000749_muscle_degeneration | 1.78413581 |
| 41 | MP0005423_abnormal_somatic_nervous | 1.76859738 |
| 42 | MP0003880_abnormal_central_pattern | 1.66879823 |
| 43 | MP0003828_pulmonary_edema | 1.66305439 |
| 44 | MP0005165_increased_susceptibility_to | 1.61978150 |
| 45 | MP0005646_abnormal_pituitary_gland | 1.60635100 |
| 46 | MP0004087_abnormal_muscle_fiber | 1.60358958 |
| 47 | MP0010630_abnormal_cardiac_muscle | 1.58834984 |
| 48 | MP0003635_abnormal_synaptic_transmissio | 1.58417399 |
| 49 | MP0001486_abnormal_startle_reflex | 1.56143080 |
| 50 | MP0010030_abnormal_orbit_morphology | 1.54513789 |
| 51 | MP0002882_abnormal_neuron_morphology | 1.52264302 |
| 52 | MP0001664_abnormal_digestion | 1.50246401 |
| 53 | MP0002272_abnormal_nervous_system | 1.49835636 |
| 54 | MP0002067_abnormal_sensory_capabilities | 1.49830715 |
| 55 | MP0005503_abnormal_tendon_morphology | 1.48855960 |
| 56 | MP0004859_abnormal_synaptic_plasticity | 1.47704581 |
| 57 | MP0001545_abnormal_hematopoietic_system | 1.46377305 |
| 58 | MP0005397_hematopoietic_system_phenotyp | 1.46377305 |
| 59 | MP0002234_abnormal_pharynx_morphology | 1.45705675 |
| 60 | MP0004036_abnormal_muscle_relaxation | 1.43058170 |
| 61 | MP0003638_abnormal_response/metabolism_ | 1.40461336 |
| 62 | MP0003045_fibrosis | 1.40222086 |
| 63 | MP0003868_abnormal_feces_composition | 1.37661225 |
| 64 | MP0002734_abnormal_mechanical_nocicepti | 1.34896737 |
| 65 | MP0002184_abnormal_innervation | 1.33309491 |
| 66 | MP0008874_decreased_physiological_sensi | 1.33115140 |
| 67 | MP0009764_decreased_sensitivity_to | 1.32594584 |
| 68 | MP0002064_seizures | 1.32089158 |
| 69 | MP0005167_abnormal_blood-brain_barrier | 1.30102372 |
| 70 | MP0010368_abnormal_lymphatic_system | 1.28639982 |
| 71 | MP0004215_abnormal_myocardial_fiber | 1.28256729 |
| 72 | MP0003879_abnormal_hair_cell | 1.23257545 |
| 73 | MP0005666_abnormal_adipose_tissue | 1.22960020 |
| 74 | MP0002063_abnormal_learning/memory/cond | 1.22803494 |
| 75 | MP0002653_abnormal_ependyma_morphology | 1.20710158 |
| 76 | MP0002909_abnormal_adrenal_gland | 1.19628180 |
| 77 | MP0003724_increased_susceptibility_to | 1.18927154 |
| 78 | MP0003890_abnormal_embryonic-extraembry | 1.17711651 |
| 79 | MP0008569_lethality_at_weaning | 1.17340018 |
| 80 | MP0002733_abnormal_thermal_nociception | 1.17217202 |
| 81 | MP0006036_abnormal_mitochondrial_physio | 1.15315962 |
| 82 | MP0005248_abnormal_Harderian_gland | 1.13528678 |
| 83 | MP0002106_abnormal_muscle_physiology | 1.13231822 |
| 84 | MP0003787_abnormal_imprinting | 1.10895721 |
| 85 | MP0001968_abnormal_touch/_nociception | 1.08183300 |
| 86 | MP0001346_abnormal_lacrimal_gland | 1.05338268 |
| 87 | MP0005083_abnormal_biliary_tract | 1.02968439 |
| 88 | MP0009745_abnormal_behavioral_response | 1.02504729 |
| 89 | MP0005369_muscle_phenotype | 1.00144083 |
| 90 | MP0001529_abnormal_vocalization | 0.96898712 |
| 91 | MP0004270_analgesia | 0.96165818 |
| 92 | MP0002822_catalepsy | 0.95689865 |
| 93 | MP0005410_abnormal_fertilization | 0.93607266 |
| 94 | MP0002572_abnormal_emotion/affect_behav | 0.93092737 |
| 95 | MP0002332_abnormal_exercise_endurance | 0.91458854 |
| 96 | MP0000465_gastrointestinal_hemorrhage | 0.88504486 |
| 97 | MP0005360_urolithiasis | 0.87976949 |
| 98 | MP0003566_abnormal_cell_adhesion | 0.85678272 |
| 99 | MP0004084_abnormal_cardiac_muscle | 0.84067628 |
| 100 | MP0001188_hyperpigmentation | 0.82614645 |
| 101 | MP0002148_abnormal_hypersensitivity_rea | 0.82427354 |
| 102 | MP0001501_abnormal_sleep_pattern | 0.81805094 |
| 103 | MP0004742_abnormal_vestibular_system | 0.78851689 |
| 104 | MP0004782_abnormal_surfactant_physiolog | 0.78547350 |
| 105 | MP0000631_abnormal_neuroendocrine_gland | 0.76080387 |
| 106 | MP0005595_abnormal_vascular_smooth | 0.75751933 |
| 107 | MP0003183_abnormal_peptide_metabolism | 0.75642810 |
| 108 | MP0000358_abnormal_cell_content/ | 0.75305819 |
| 109 | MP0005197_abnormal_uvea_morphology | 0.75173022 |
| 110 | MP0000569_abnormal_digit_pigmentation | 0.74062627 |
| 111 | MP0002736_abnormal_nociception_after | 0.73173168 |
| 112 | MP0003941_abnormal_skin_development | 0.73038720 |
| 113 | MP0008004_abnormal_stomach_pH | 0.72419870 |
| 114 | MP0005076_abnormal_cell_differentiation | 0.71815250 |
| 115 | MP0001851_eye_inflammation | 0.71598755 |
| 116 | MP0000015_abnormal_ear_pigmentation | 0.71580621 |
| 117 | MP0003634_abnormal_glial_cell | 0.71051567 |
| 118 | MP0009765_abnormal_xenobiotic_induced | 0.69931826 |
| 119 | MP0000249_abnormal_blood_vessel | 0.69499619 |
| 120 | MP0009333_abnormal_splenocyte_physiolog | 0.69121556 |
| 121 | MP0005670_abnormal_white_adipose | 0.68639652 |
| 122 | MP0004811_abnormal_neuron_physiology | 0.68288884 |
| 123 | MP0002128_abnormal_blood_circulation | 0.66473858 |
| 124 | MP0004019_abnormal_vitamin_homeostasis | 0.65379128 |
| 125 | MP0005620_abnormal_muscle_contractility | 0.65240282 |
| 126 | MP0005375_adipose_tissue_phenotype | 0.64439958 |
| 127 | MP0000751_myopathy | 0.64055313 |
| 128 | MP0006276_abnormal_autonomic_nervous | 0.63806805 |
| 129 | MP0000750_abnormal_muscle_regeneration | 0.63694016 |
| 130 | MP0002971_abnormal_brown_adipose | 0.63082602 |
| 131 | MP0004885_abnormal_endolymph | 0.62835158 |
| 132 | MP0004043_abnormal_pH_regulation | 0.62450412 |
| 133 | MP0010329_abnormal_lipoprotein_level | 0.62074125 |
| 134 | MP0009763_increased_sensitivity_to | 0.60800864 |
| 135 | MP0004924_abnormal_behavior | 0.58779814 |
| 136 | MP0005386_behavior/neurological_phenoty | 0.58779814 |
| 137 | MP0004085_abnormal_heartbeat | 0.58679217 |
| 138 | MP0000681_abnormal_thyroid_gland | 0.58582952 |
| 139 | MP0000678_abnormal_parathyroid_gland | 0.57155177 |
| 140 | MP0000955_abnormal_spinal_cord | 0.56750824 |
| 141 | MP0002066_abnormal_motor_capabilities/c | 0.56400403 |
| 142 | MP0002557_abnormal_social/conspecific_i | 0.55746632 |
| 143 | MP0008775_abnormal_heart_ventricle | 0.55015447 |
| 144 | MP0002127_abnormal_cardiovascular_syste | 0.54943474 |
| 145 | MP0002277_abnormal_respiratory_mucosa | 0.54791399 |
| 146 | MP0001764_abnormal_homeostasis | 0.54712908 |
| 147 | MP0005671_abnormal_response_to | 0.54459550 |
| 148 | MP0001765_abnormal_ion_homeostasis | 0.54392536 |
| 149 | MP0005334_abnormal_fat_pad | 0.54346521 |
| 150 | MP0002697_abnormal_eye_size | 0.53186473 |
| 151 | MP0002269_muscular_atrophy | 0.50774630 |
| 152 | MP0002118_abnormal_lipid_homeostasis | 0.50481650 |
| 153 | MP0004142_abnormal_muscle_tone | 0.50040621 |
| 154 | MP0001963_abnormal_hearing_physiology | 0.49865516 |
| 155 | MP0004147_increased_porphyrin_level | 0.48907045 |
| 156 | MP0003633_abnormal_nervous_system | 0.47729588 |
| 157 | MP0002152_abnormal_brain_morphology | 0.47683056 |
| 158 | MP0002089_abnormal_postnatal_growth/wei | 0.46570921 |
| 159 | MP0005220_abnormal_exocrine_pancreas | 0.44296213 |
| 160 | MP0001440_abnormal_grooming_behavior | 0.42829132 |
| 161 | MP0001293_anophthalmia | 0.42363065 |
| 162 | MP0008877_abnormal_DNA_methylation | 0.42357858 |
| 163 | MP0000534_abnormal_ureter_morphology | 0.41889380 |
| 164 | MP0001970_abnormal_pain_threshold | 0.41460983 |
| 165 | MP0001879_abnormal_lymphatic_vessel | 0.40696835 |
| 166 | MP0008872_abnormal_physiological_respon | 0.39755473 |
| 167 | MP0009697_abnormal_copulation | 0.39738934 |
| 168 | MP0005187_abnormal_penis_morphology | 0.38680891 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Central scotoma (HP:0000603) | 8.90893532 |
| 2 | Abnormal rod and cone electroretinograms (HP:0008323) | 8.73686400 |
| 3 | Abnormality of macular pigmentation (HP:0008002) | 7.85401740 |
| 4 | Bony spicule pigmentary retinopathy (HP:0007737) | 7.76668616 |
| 5 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 7.46465607 |
| 6 | Thyroid-stimulating hormone excess (HP:0002925) | 7.07886427 |
| 7 | Scotoma (HP:0000575) | 6.98732151 |
| 8 | Severe visual impairment (HP:0001141) | 6.97776577 |
| 9 | Keratoconus (HP:0000563) | 6.85785201 |
| 10 | Increased corneal curvature (HP:0100692) | 6.85785201 |
| 11 | Bundle branch block (HP:0011710) | 6.77521989 |
| 12 | Prolonged bleeding time (HP:0003010) | 6.45687110 |
| 13 | Decreased central vision (HP:0007663) | 6.41369602 |
| 14 | Sudden death (HP:0001699) | 6.22207769 |
| 15 | Pendular nystagmus (HP:0012043) | 5.91175007 |
| 16 | Menorrhagia (HP:0000132) | 5.85424772 |
| 17 | Dyschromatopsia (HP:0007641) | 5.50393140 |
| 18 | Increased mean platelet volume (HP:0011877) | 5.38384626 |
| 19 | Abolished electroretinogram (ERG) (HP:0000550) | 5.35393013 |
| 20 | Chorioretinal atrophy (HP:0000533) | 5.29346611 |
| 21 | Pigmentary retinal degeneration (HP:0001146) | 5.14073320 |
| 22 | Hyperlipoproteinemia (HP:0010980) | 5.03411318 |
| 23 | Abnormal platelet volume (HP:0011876) | 4.95759858 |
| 24 | Attenuation of retinal blood vessels (HP:0007843) | 4.92072298 |
| 25 | Primary atrial arrhythmia (HP:0001692) | 4.75395841 |
| 26 | Supraventricular tachycardia (HP:0004755) | 4.59081938 |
| 27 | Hyporeflexia of lower limbs (HP:0002600) | 4.53818512 |
| 28 | Ventricular tachycardia (HP:0004756) | 4.49757344 |
| 29 | Petechiae (HP:0000967) | 4.44953498 |
| 30 | Supraventricular arrhythmia (HP:0005115) | 4.44800571 |
| 31 | Purpura (HP:0000979) | 4.40437573 |
| 32 | Epistaxis (HP:0000421) | 4.22966993 |
| 33 | Heart block (HP:0012722) | 4.19131747 |
| 34 | Ventricular fibrillation (HP:0001663) | 4.05965701 |
| 35 | Photophobia (HP:0000613) | 4.04718426 |
| 36 | Type II diabetes mellitus (HP:0005978) | 3.94647743 |
| 37 | Lipoatrophy (HP:0100578) | 3.94624877 |
| 38 | Abnormal atrioventricular conduction (HP:0005150) | 3.93759767 |
| 39 | Muscle fiber splitting (HP:0003555) | 3.86991075 |
| 40 | Constricted visual fields (HP:0001133) | 3.84291803 |
| 41 | Epileptic encephalopathy (HP:0200134) | 3.78778566 |
| 42 | Macular degeneration (HP:0000608) | 3.62820695 |
| 43 | Cerebellar dysplasia (HP:0007033) | 3.51327887 |
| 44 | Cone-rod dystrophy (HP:0000548) | 3.44919978 |
| 45 | Right ventricular cardiomyopathy (HP:0011663) | 3.43762861 |
| 46 | Absence seizures (HP:0002121) | 3.43621650 |
| 47 | Ventricular arrhythmia (HP:0004308) | 3.39407924 |
| 48 | Posterior subcapsular cataract (HP:0007787) | 3.32509153 |
| 49 | Retinitis pigmentosa (HP:0000510) | 3.26166406 |
| 50 | Distal lower limb muscle weakness (HP:0009053) | 3.19687034 |
| 51 | Dilated cardiomyopathy (HP:0001644) | 3.18875311 |
| 52 | Cholecystitis (HP:0001082) | 3.17691748 |
| 53 | Abnormal gallbladder physiology (HP:0012438) | 3.17691748 |
| 54 | Choroideremia (HP:0001139) | 3.13694244 |
| 55 | Febrile seizures (HP:0002373) | 3.08969295 |
| 56 | Gingival bleeding (HP:0000225) | 3.06312313 |
| 57 | Abnormality of the calf musculature (HP:0001430) | 3.00379993 |
| 58 | Vitreoretinal degeneration (HP:0000655) | 3.00045202 |
| 59 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.96707144 |
| 60 | Left ventricular hypertrophy (HP:0001712) | 2.95195113 |
| 61 | Septo-optic dysplasia (HP:0100842) | 2.92848117 |
| 62 | Asymmetric septal hypertrophy (HP:0001670) | 2.86386294 |
| 63 | Atrioventricular block (HP:0001678) | 2.85267204 |
| 64 | Palpitations (HP:0001962) | 2.84174940 |
| 65 | Hypoplasia of the fovea (HP:0007750) | 2.81414921 |
| 66 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.81414921 |
| 67 | Impaired platelet aggregation (HP:0003540) | 2.79625833 |
| 68 | Abnormal platelet function (HP:0011869) | 2.79625833 |
| 69 | Poikilocytosis (HP:0004447) | 2.77402511 |
| 70 | Subaortic stenosis (HP:0001682) | 2.77233010 |
| 71 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.77233010 |
| 72 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.76893350 |
| 73 | Areflexia of lower limbs (HP:0002522) | 2.73688167 |
| 74 | Calf muscle hypertrophy (HP:0008981) | 2.71054413 |
| 75 | Dialeptic seizures (HP:0011146) | 2.65700676 |
| 76 | Partial agenesis of the corpus callosum (HP:0001338) | 2.58639377 |
| 77 | Abnormality of the fovea (HP:0000493) | 2.57076962 |
| 78 | Progressive cerebellar ataxia (HP:0002073) | 2.50929798 |
| 79 | Muscle hypertrophy of the lower extremities (HP:0008968) | 2.42123092 |
| 80 | Spontaneous hematomas (HP:0007420) | 2.39301158 |
| 81 | Congenital sensorineural hearing impairment (HP:0008527) | 2.36933219 |
| 82 | Acanthocytosis (HP:0001927) | 2.35594381 |
| 83 | Abnormality of the aortic arch (HP:0012303) | 2.33281683 |
| 84 | Bruising susceptibility (HP:0000978) | 2.31607331 |
| 85 | Agitation (HP:0000713) | 2.30652721 |
| 86 | Dysdiadochokinesis (HP:0002075) | 2.29416510 |
| 87 | Xanthomatosis (HP:0000991) | 2.28975064 |
| 88 | Distal lower limb amyotrophy (HP:0008944) | 2.24633727 |
| 89 | Abnormal pupillary function (HP:0007686) | 2.23742921 |
| 90 | EMG: myopathic abnormalities (HP:0003458) | 2.21178873 |
| 91 | 3-Methylglutaconic aciduria (HP:0003535) | 2.18553986 |
| 92 | Sudden cardiac death (HP:0001645) | 2.17838668 |
| 93 | EEG with generalized epileptiform discharges (HP:0011198) | 2.17144570 |
| 94 | Generalized tonic-clonic seizures (HP:0002069) | 2.15732419 |
| 95 | Testicular neoplasm (HP:0010788) | 2.14315633 |
| 96 | Optic disc pallor (HP:0000543) | 2.13748058 |
| 97 | Large for gestational age (HP:0001520) | 2.12794205 |
| 98 | Aplasia/Hypoplasia of the macula (HP:0008059) | 2.12629503 |
| 99 | Abnormality of the common coagulation pathway (HP:0010990) | 2.09735208 |
| 100 | Conjunctival telangiectasia (HP:0000524) | 2.09265110 |
| 101 | Epileptiform EEG discharges (HP:0011182) | 2.08086406 |
| 102 | Intestinal atresia (HP:0011100) | 2.05343098 |
| 103 | Gait imbalance (HP:0002141) | 2.04832701 |
| 104 | EMG: neuropathic changes (HP:0003445) | 2.01667026 |
| 105 | Congenital stationary night blindness (HP:0007642) | 14.6386520 |
| 106 | Nausea (HP:0002018) | 1.99969803 |
| 107 | Vertigo (HP:0002321) | 1.99351389 |
| 108 | Joint hemorrhage (HP:0005261) | 1.98305537 |
| 109 | Broad alveolar ridges (HP:0000187) | 1.97263238 |
| 110 | Tinnitus (HP:0000360) | 1.96974747 |
| 111 | Difficulty walking (HP:0002355) | 1.96699279 |
| 112 | Congenital primary aphakia (HP:0007707) | 1.96652056 |
| 113 | Albinism (HP:0001022) | 1.96050649 |
| 114 | Aplasia/Hypoplasia affecting the retina (HP:0008061) | 1.95695536 |
| 115 | Ragged-red muscle fibers (HP:0003200) | 1.92890163 |
| 116 | Abnormality of abdominal situs (HP:0011620) | 1.92276685 |
| 117 | Abdominal situs inversus (HP:0003363) | 1.92276685 |
| 118 | Thickened helices (HP:0000391) | 1.91105703 |
| 119 | True hermaphroditism (HP:0010459) | 1.90531471 |
| 120 | Hyperthyroidism (HP:0000836) | 1.89795636 |
| 121 | Increased variability in muscle fiber diameter (HP:0003557) | 1.89399064 |
| 122 | Heterotopia (HP:0002282) | 1.88914586 |
| 123 | Subcapsular cataract (HP:0000523) | 1.87195901 |
| 124 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.85592176 |
| 125 | Progressive visual loss (HP:0000529) | 1.85502251 |
| 126 | Atonic seizures (HP:0010819) | 1.84434958 |
| 127 | Widely spaced teeth (HP:0000687) | 1.82748397 |
| 128 | Palmoplantar keratoderma (HP:0000982) | 1.80288167 |
| 129 | Astigmatism (HP:0000483) | 1.79190488 |
| 130 | Abnormality of lateral ventricle (HP:0030047) | 1.77217734 |
| 131 | Prolonged QT interval (HP:0001657) | 1.76727086 |
| 132 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.76702801 |
| 133 | Myoglobinuria (HP:0002913) | 1.72986046 |
| 134 | Focal motor seizures (HP:0011153) | 1.72966431 |
| 135 | Nephrogenic diabetes insipidus (HP:0009806) | 1.72585663 |
| 136 | Dysmetric saccades (HP:0000641) | 1.72414863 |
| 137 | Severe Myopia (HP:0011003) | 1.72322580 |
| 138 | Increased density of long bones (HP:0006392) | 1.68919526 |
| 139 | Horizontal nystagmus (HP:0000666) | 1.68912777 |
| 140 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.68890122 |
| 141 | Mesangial abnormality (HP:0001966) | 1.67744664 |
| 142 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.67630127 |
| 143 | Hypercortisolism (HP:0001578) | 1.67619014 |
| 144 | Abnormal auditory evoked potentials (HP:0006958) | 1.67165578 |
| 145 | Rimmed vacuoles (HP:0003805) | 1.65684064 |
| 146 | Oligodontia (HP:0000677) | 1.65666916 |
| 147 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 1.65212655 |
| 148 | Medial flaring of the eyebrow (HP:0010747) | 1.65051433 |
| 149 | Depression (HP:0000716) | 1.64974133 |
| 150 | Visual hallucinations (HP:0002367) | 1.63510254 |
| 151 | Wide nasal bridge (HP:0000431) | 1.61514602 |
| 152 | Truncal ataxia (HP:0002078) | 1.59558158 |
| 153 | Gaze-evoked nystagmus (HP:0000640) | 1.58849671 |
| 154 | Aplasia/Hypoplasia affecting the fundus (HP:0008057) | 1.48592213 |
| 155 | Pancreatic fibrosis (HP:0100732) | 1.45707436 |
| 156 | Maternal diabetes (HP:0009800) | 1.43831894 |
| 157 | Abnormality of alanine metabolism (HP:0010916) | 1.43515458 |
| 158 | Hyperalaninemia (HP:0003348) | 1.43515458 |
| 159 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.43515458 |
| 160 | Vaginal atresia (HP:0000148) | 1.43502694 |
| 161 | Genital tract atresia (HP:0001827) | 1.42122002 |
| 162 | Poor coordination (HP:0002370) | 1.41944987 |
| 163 | Volvulus (HP:0002580) | 1.39825559 |
| 164 | Optic nerve hypoplasia (HP:0000609) | 1.39686282 |
| 165 | Mutism (HP:0002300) | 1.37790841 |
| 166 | Megalencephaly (HP:0001355) | 1.36972346 |
| 167 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.36948509 |
| 168 | Action tremor (HP:0002345) | 1.36794329 |
| 169 | Abnormal EKG (HP:0003115) | 1.36574153 |
| 170 | Myokymia (HP:0002411) | 1.36317598 |
| 171 | Retinal atrophy (HP:0001105) | 1.36142916 |
| 172 | Abnormality of the septum pellucidum (HP:0007375) | 1.35739561 |
| 173 | Focal seizures (HP:0007359) | 1.35702239 |
| 174 | Syncope (HP:0001279) | 1.32861212 |
| 175 | Absent septum pellucidum (HP:0001331) | 1.30108708 |
| 176 | Neoplasm of the heart (HP:0100544) | 1.29745865 |
| 177 | Atrial fibrillation (HP:0005110) | 1.26435755 |
| 178 | Exercise-induced myalgia (HP:0003738) | 1.25627787 |
| 179 | Optic atrophy (HP:0000648) | 1.23961700 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYLK | 7.06230009 |
| 2 | ADRBK2 | 5.86352301 |
| 3 | NEK1 | 3.47395434 |
| 4 | TTN | 3.18397429 |
| 5 | NME1 | 3.12220509 |
| 6 | MST4 | 2.95711810 |
| 7 | STK38L | 2.82291428 |
| 8 | GRK1 | 2.73986723 |
| 9 | PAK6 | 2.73484027 |
| 10 | PRPF4B | 2.50506503 |
| 11 | FRK | 2.41273130 |
| 12 | RIPK1 | 2.22922765 |
| 13 | BMX | 2.22586036 |
| 14 | RIPK4 | 2.21958570 |
| 15 | OBSCN | 2.19495473 |
| 16 | PBK | 11.8054248 |
| 17 | STK38 | 1.97935892 |
| 18 | DMPK | 1.96828851 |
| 19 | ADRBK1 | 1.92500128 |
| 20 | MAP3K13 | 1.80489219 |
| 21 | PINK1 | 1.77950703 |
| 22 | MAPKAPK3 | 1.75129841 |
| 23 | ACVR1B | 1.72282364 |
| 24 | TEC | 1.68085730 |
| 25 | PTK2B | 1.59554351 |
| 26 | CDK3 | 1.58827849 |
| 27 | TAOK2 | 1.58816848 |
| 28 | PKN2 | 1.53699839 |
| 29 | FES | 1.48808368 |
| 30 | MINK1 | 1.48097793 |
| 31 | MARK1 | 1.46836557 |
| 32 | DYRK1A | 1.46243030 |
| 33 | BTK | 1.45154147 |
| 34 | MAP3K4 | 1.40237003 |
| 35 | PIK3CG | 1.39025517 |
| 36 | TAOK3 | 1.36794062 |
| 37 | PNCK | 1.36728371 |
| 38 | PRKD1 | 1.36505394 |
| 39 | PHKG2 | 1.30546358 |
| 40 | PHKG1 | 1.30546358 |
| 41 | MAP3K9 | 1.28694277 |
| 42 | STK4 | 1.27839630 |
| 43 | ERN1 | 1.27222304 |
| 44 | PLK2 | 1.24065887 |
| 45 | CAMK2D | 1.22482755 |
| 46 | SYK | 1.16331404 |
| 47 | IRAK3 | 1.12093738 |
| 48 | ILK | 1.09161289 |
| 49 | PRKD3 | 1.06364330 |
| 50 | LMTK2 | 1.04948804 |
| 51 | KSR2 | 1.04883464 |
| 52 | EIF2AK1 | 1.02411727 |
| 53 | CSF1R | 1.01459711 |
| 54 | NEK9 | 1.01369178 |
| 55 | PRKAA1 | 1.00721099 |
| 56 | MAP3K7 | 1.00425479 |
| 57 | MAP2K7 | 0.99514433 |
| 58 | GRK7 | 0.95417092 |
| 59 | EPHA4 | 0.94615850 |
| 60 | ITK | 0.90683278 |
| 61 | DAPK3 | 0.89520881 |
| 62 | ZAP70 | 0.88398283 |
| 63 | DYRK1B | 0.87791556 |
| 64 | INSRR | 0.87269118 |
| 65 | CAMK1D | 0.86920477 |
| 66 | STK3 | 0.86530511 |
| 67 | TRPM7 | 0.80778127 |
| 68 | PIK3CA | 0.79737228 |
| 69 | PRKD2 | 0.77200636 |
| 70 | MAP3K5 | 0.76894267 |
| 71 | MAP3K6 | 0.76419676 |
| 72 | PAK3 | 0.75710437 |
| 73 | ERBB3 | 0.75707565 |
| 74 | FER | 0.75522554 |
| 75 | CAMK1G | 0.72226323 |
| 76 | MUSK | 0.71482816 |
| 77 | MARK3 | 0.70296579 |
| 78 | PDK1 | 0.68703266 |
| 79 | ERBB2 | 0.68151475 |
| 80 | BMPR1B | 0.67411566 |
| 81 | CDK14 | 0.66836334 |
| 82 | GRK6 | 0.66381493 |
| 83 | MAPK11 | 0.65870751 |
| 84 | STK24 | 0.65827260 |
| 85 | ROCK1 | 0.65026278 |
| 86 | CLK1 | 0.61924408 |
| 87 | TGFBR1 | 0.60042468 |
| 88 | IRAK2 | 0.55895890 |
| 89 | SGK494 | 0.54735884 |
| 90 | SGK223 | 0.54735884 |
| 91 | CAMK1 | 0.53423917 |
| 92 | HCK | 0.53316747 |
| 93 | DYRK3 | 0.53263916 |
| 94 | MAP3K12 | 0.52588749 |
| 95 | MAPK7 | 0.51439634 |
| 96 | CDC42BPA | 0.51387232 |
| 97 | FLT3 | 0.50469284 |
| 98 | PKN1 | 0.50049026 |
| 99 | CHEK2 | 0.49207439 |
| 100 | CDK5 | 0.48823502 |
| 101 | PRKG2 | 0.48209172 |
| 102 | CDK15 | 0.47398937 |
| 103 | KSR1 | 0.46156308 |
| 104 | PRKCZ | 0.45971168 |
| 105 | PRKCB | 0.43818061 |
| 106 | CDK18 | 0.43347624 |
| 107 | CAMK2A | 0.43001535 |
| 108 | MAP2K4 | 0.41536700 |
| 109 | ARAF | 0.41215267 |
| 110 | IRAK1 | 0.39458209 |
| 111 | BRD4 | 0.39293174 |
| 112 | PRKCA | 0.38826731 |
| 113 | DAPK2 | 0.38673786 |
| 114 | CDK11A | 0.37759037 |
| 115 | PRKAA2 | 0.37709408 |
| 116 | NEK2 | 0.37308786 |
| 117 | PDPK1 | 0.36887998 |
| 118 | FGFR1 | 0.35486056 |
| 119 | PDK2 | 0.35443632 |
| 120 | MARK2 | 0.34862041 |
| 121 | PRKCE | 0.34079072 |
| 122 | RPS6KA3 | 0.33037532 |
| 123 | PAK1 | 0.32452897 |
| 124 | CAMKK1 | 0.32362480 |
| 125 | NTRK2 | 0.31741537 |
| 126 | TYRO3 | 0.31215672 |
| 127 | PRKCG | 0.30965850 |
| 128 | MAPK10 | 0.30865686 |
| 129 | PRKG1 | 0.30706395 |
| 130 | SIK2 | 0.30614134 |
| 131 | TIE1 | 0.30583116 |
| 132 | FGR | 0.30500215 |
| 133 | CAMK2G | 0.30161642 |
| 134 | PRKCD | 0.29501441 |
| 135 | EPHB2 | 0.29387176 |
| 136 | PRKACA | 0.29343039 |
| 137 | GSK3B | 0.28989673 |
| 138 | TLK1 | 0.28849931 |
| 139 | GRK5 | 0.28083026 |
| 140 | CSNK1D | 0.27607942 |
| 141 | FYN | 0.25940109 |
| 142 | HIPK2 | 0.25774563 |
| 143 | EPHA3 | 0.25552519 |
| 144 | ROCK2 | 0.25386936 |
| 145 | RET | 0.25326014 |
| 146 | PRKCH | 0.25323034 |
| 147 | BMPR2 | 0.24685117 |
| 148 | MAPK12 | 0.24394639 |
| 149 | PRKACG | 0.24384688 |
| 150 | LYN | 0.23927681 |
| 151 | MAPK9 | 0.23479975 |
| 152 | WNK3 | 0.22701419 |
| 153 | CAMK4 | 0.22678564 |
| 154 | IKBKB | 0.22453490 |
| 155 | TXK | 0.22439397 |
| 156 | STK39 | 0.21348733 |
| 157 | AKT3 | 0.20626649 |
| 158 | MAPK8 | 0.20230570 |
| 159 | TNK2 | 0.20103783 |
| 160 | MAP2K1 | 0.19597451 |
| 161 | MAPK14 | 0.18850152 |
| 162 | AKT2 | 0.18784162 |
| 163 | PTK6 | 0.18731926 |
| 164 | MAPK13 | 0.18682134 |
| 165 | TNIK | 0.18644480 |
| 166 | MAPK1 | 0.17547652 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Phototransduction_Homo sapiens_hsa04744 | 8.53720944 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.76579210 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 3.70758179 |
| 4 | Nicotine addiction_Homo sapiens_hsa05033 | 3.31299293 |
| 5 | Platelet activation_Homo sapiens_hsa04611 | 3.27679661 |
| 6 | Morphine addiction_Homo sapiens_hsa05032 | 3.14489209 |
| 7 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.94004755 |
| 8 | Olfactory transduction_Homo sapiens_hsa04740 | 2.75062324 |
| 9 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 2.57391906 |
| 10 | Circadian rhythm_Homo sapiens_hsa04710 | 2.44789562 |
| 11 | Circadian entrainment_Homo sapiens_hsa04713 | 2.22782301 |
| 12 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.85618674 |
| 13 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.84902180 |
| 14 | Insulin secretion_Homo sapiens_hsa04911 | 1.82405432 |
| 15 | Taste transduction_Homo sapiens_hsa04742 | 1.73179212 |
| 16 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.66736434 |
| 17 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.62348384 |
| 18 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.60863933 |
| 19 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.60301779 |
| 20 | Renin secretion_Homo sapiens_hsa04924 | 1.57143395 |
| 21 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.55413973 |
| 22 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.51435506 |
| 23 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.49658524 |
| 24 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.48198022 |
| 25 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.44771727 |
| 26 | Salivary secretion_Homo sapiens_hsa04970 | 1.38192184 |
| 27 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.37242411 |
| 28 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.34074048 |
| 29 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.33382940 |
| 30 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.31489773 |
| 31 | Parkinsons disease_Homo sapiens_hsa05012 | 1.25504670 |
| 32 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.25226007 |
| 33 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.24250674 |
| 34 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.19357994 |
| 35 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.18039726 |
| 36 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.16905634 |
| 37 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.16882551 |
| 38 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.16736207 |
| 39 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.16023781 |
| 40 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.12299834 |
| 41 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.12281314 |
| 42 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.09425686 |
| 43 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.04784181 |
| 44 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.04233923 |
| 45 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.03909522 |
| 46 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.01566024 |
| 47 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.00469985 |
| 48 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.93710133 |
| 49 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.92598352 |
| 50 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.92100697 |
| 51 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.91559131 |
| 52 | Retinol metabolism_Homo sapiens_hsa00830 | 0.91280686 |
| 53 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.89945281 |
| 54 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.89922777 |
| 55 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.88545685 |
| 56 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.87522651 |
| 57 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.87415025 |
| 58 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.86557307 |
| 59 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.82192845 |
| 60 | Alzheimers disease_Homo sapiens_hsa05010 | 0.79146447 |
| 61 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.75302796 |
| 62 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.74954013 |
| 63 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.74513004 |
| 64 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.70373965 |
| 65 | Alcoholism_Homo sapiens_hsa05034 | 0.70001287 |
| 66 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.69538210 |
| 67 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.68580728 |
| 68 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.64421051 |
| 69 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.64095566 |
| 70 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.63511304 |
| 71 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.62513288 |
| 72 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.62277293 |
| 73 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.60630111 |
| 74 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.60494904 |
| 75 | Focal adhesion_Homo sapiens_hsa04510 | 0.59236379 |
| 76 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.58020991 |
| 77 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.57843444 |
| 78 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.55780441 |
| 79 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.55495231 |
| 80 | Gap junction_Homo sapiens_hsa04540 | 0.54859640 |
| 81 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.54232794 |
| 82 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.53690557 |
| 83 | Colorectal cancer_Homo sapiens_hsa05210 | 0.52603193 |
| 84 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.51846449 |
| 85 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.51229709 |
| 86 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.51053026 |
| 87 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.50427304 |
| 88 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.49164981 |
| 89 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.47974564 |
| 90 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.45966285 |
| 91 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.45045820 |
| 92 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.44822528 |
| 93 | Carbon metabolism_Homo sapiens_hsa01200 | 0.43335066 |
| 94 | Galactose metabolism_Homo sapiens_hsa00052 | 0.43158838 |
| 95 | ABC transporters_Homo sapiens_hsa02010 | 0.43072847 |
| 96 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.42495852 |
| 97 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.41219588 |
| 98 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.39419249 |
| 99 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.39166260 |
| 100 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.39007766 |
| 101 | Huntingtons disease_Homo sapiens_hsa05016 | 0.38146825 |
| 102 | Sulfur relay system_Homo sapiens_hsa04122 | 0.37112817 |
| 103 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.36836511 |
| 104 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.35510088 |
| 105 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.35411467 |
| 106 | Cocaine addiction_Homo sapiens_hsa05030 | 0.34408352 |
| 107 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.34349277 |
| 108 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.32704102 |
| 109 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.32421738 |
| 110 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.32245614 |
| 111 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.32190100 |
| 112 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.32168975 |
| 113 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.31672312 |
| 114 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.31365505 |
| 115 | Bile secretion_Homo sapiens_hsa04976 | 0.30514838 |
| 116 | Glioma_Homo sapiens_hsa05214 | 0.29542559 |
| 117 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.29343264 |
| 118 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.28531073 |
| 119 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.28465140 |
| 120 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.28121704 |
| 121 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.28059664 |
| 122 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.27062568 |
| 123 | Long-term depression_Homo sapiens_hsa04730 | 0.27043324 |
| 124 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.26891343 |
| 125 | Endometrial cancer_Homo sapiens_hsa05213 | 0.26773500 |
| 126 | Long-term potentiation_Homo sapiens_hsa04720 | 0.26708103 |
| 127 | Purine metabolism_Homo sapiens_hsa00230 | 0.26581300 |
| 128 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.26056121 |
| 129 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.25691721 |
| 130 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.22379869 |
| 131 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.22128513 |
| 132 | Mineral absorption_Homo sapiens_hsa04978 | 0.22068663 |
| 133 | Melanoma_Homo sapiens_hsa05218 | 0.20333126 |
| 134 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.20241272 |
| 135 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.19487381 |
| 136 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.19275085 |
| 137 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.19200940 |
| 138 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.18016599 |
| 139 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.16951991 |
| 140 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.16667939 |
| 141 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.14859252 |
| 142 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.13417203 |
| 143 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.13396983 |
| 144 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.11158758 |
| 145 | Axon guidance_Homo sapiens_hsa04360 | 0.08676760 |

