RDH10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin A metabolic process (GO:0006776)5.72201976
2cysteine metabolic process (GO:0006534)5.32651241
3axonemal dynein complex assembly (GO:0070286)5.26163676
4* diterpenoid biosynthetic process (GO:0016102)4.57858335
5sulfur amino acid catabolic process (GO:0000098)4.49008298
6primary alcohol catabolic process (GO:0034310)4.40685474
7regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.25505639
8serine family amino acid catabolic process (GO:0009071)4.21268851
9urate metabolic process (GO:0046415)4.10802200
10L-phenylalanine metabolic process (GO:0006558)4.09975338
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.09975338
12type B pancreatic cell proliferation (GO:0044342)4.05380314
13metanephric mesenchyme development (GO:0072075)4.01683909
14homocysteine metabolic process (GO:0050667)3.98837412
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.98673249
16L-phenylalanine catabolic process (GO:0006559)3.98673249
17kidney mesenchyme development (GO:0072074)3.95176072
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.80399985
19glycine metabolic process (GO:0006544)3.76415534
20vitamin transmembrane transport (GO:0035461)3.76316456
21serine family amino acid metabolic process (GO:0009069)3.75227461
22intestinal epithelial cell development (GO:0060576)3.71322149
23cilium movement (GO:0003341)3.64773907
24* retinal metabolic process (GO:0042574)3.63127779
25regulation of cholesterol homeostasis (GO:2000188)3.59585566
26mesenchymal-epithelial cell signaling (GO:0060638)3.57424416
27cilium or flagellum-dependent cell motility (GO:0001539)3.57346847
28aromatic amino acid family catabolic process (GO:0009074)3.57222533
29amino-acid betaine metabolic process (GO:0006577)3.49073975
30establishment of apical/basal cell polarity (GO:0035089)3.47828084
31regulation of hippo signaling (GO:0035330)3.45957706
32regulation of protein activation cascade (GO:2000257)3.45927293
33negative regulation of fibrinolysis (GO:0051918)3.44845916
34cell adhesion mediated by integrin (GO:0033627)3.43694856
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.42710472
36serine family amino acid biosynthetic process (GO:0009070)3.42702057
37sequestering of extracellular ligand from receptor (GO:0035581)3.40588346
38mesodermal cell differentiation (GO:0048333)3.40290004
39glyoxylate metabolic process (GO:0046487)3.39751743
40regulation of complement activation (GO:0030449)3.37025866
41lung-associated mesenchyme development (GO:0060484)3.36973005
42mammary gland epithelial cell proliferation (GO:0033598)3.33238924
43UDP-N-acetylglucosamine metabolic process (GO:0006047)3.32867753
44regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.29466209
45extracellular regulation of signal transduction (GO:1900115)3.29465702
46extracellular negative regulation of signal transduction (GO:1900116)3.29465702
47indolalkylamine catabolic process (GO:0046218)3.29236827
48tryptophan catabolic process (GO:0006569)3.29236827
49indole-containing compound catabolic process (GO:0042436)3.29236827
50complement activation, alternative pathway (GO:0006957)3.29036813
51ethanol metabolic process (GO:0006067)3.28831957
52folic acid metabolic process (GO:0046655)3.28549356
53urea cycle (GO:0000050)3.27655895
54urea metabolic process (GO:0019627)3.27655895
55pericardium development (GO:0060039)3.27383585
56smooth muscle tissue development (GO:0048745)3.27274383
57hepatocyte apoptotic process (GO:0097284)3.25381847
58collagen fibril organization (GO:0030199)3.24639554
59* terpenoid biosynthetic process (GO:0016114)3.24126746
60lysine catabolic process (GO:0006554)3.22629817
61lysine metabolic process (GO:0006553)3.22629817
62peptidyl-glutamic acid carboxylation (GO:0017187)3.21185842
63protein carboxylation (GO:0018214)3.21185842
64epithelial cilium movement (GO:0003351)3.20383497
65negative regulation of complement activation (GO:0045916)3.20334580
66regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.20022944
67glomerular epithelial cell development (GO:0072310)3.20005359
68midgut development (GO:0007494)3.19470616
69tryptophan metabolic process (GO:0006568)3.19065166
70keratinocyte development (GO:0003334)3.18073565
71kynurenine metabolic process (GO:0070189)3.17408121
72negative regulation of chondrocyte differentiation (GO:0032331)3.17128939
73keratan sulfate catabolic process (GO:0042340)3.15915817
74negative regulation of humoral immune response (GO:0002921)3.15843491
75bile acid biosynthetic process (GO:0006699)3.10417199
76cellular glucuronidation (GO:0052695)3.09056885
77tyrosine metabolic process (GO:0006570)3.08396865
78daunorubicin metabolic process (GO:0044597)3.07740274
79polyketide metabolic process (GO:0030638)3.07740274
80doxorubicin metabolic process (GO:0044598)3.07740274
81alpha-linolenic acid metabolic process (GO:0036109)3.07155290
82lung epithelium development (GO:0060428)3.06580717
83fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.04572868
84drug catabolic process (GO:0042737)3.04279711
85cytidine metabolic process (GO:0046087)3.03696554
86cytidine catabolic process (GO:0006216)3.03696554
87cytidine deamination (GO:0009972)3.03696554
88motile cilium assembly (GO:0044458)3.02739236
89negative regulation of protein activation cascade (GO:2000258)3.00532106
90eosinophil chemotaxis (GO:0048245)3.00322294
91desmosome organization (GO:0002934)2.99995046
92aromatic amino acid family metabolic process (GO:0009072)2.99387464
93hemidesmosome assembly (GO:0031581)2.97336171
94nitrogen cycle metabolic process (GO:0071941)2.96334957
95regulation of fibrinolysis (GO:0051917)2.96312509
96regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.95297894
97reverse cholesterol transport (GO:0043691)2.94951797
98aminoglycoside antibiotic metabolic process (GO:0030647)2.90819869
99response to nitrosative stress (GO:0051409)2.89777735
100regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.88810575
101pyrimidine-containing compound transmembrane transport (GO:0072531)2.87831626
102negative regulation of axon extension involved in axon guidance (GO:0048843)2.87731611
103* retinol metabolic process (GO:0042572)2.87131787
104flavonoid metabolic process (GO:0009812)2.87105307
105muscle cell migration (GO:0014812)2.85367030
106skin morphogenesis (GO:0043589)2.83256662
107establishment of monopolar cell polarity (GO:0061162)2.82759666
108establishment or maintenance of monopolar cell polarity (GO:0061339)2.82759666
109transcytosis (GO:0045056)2.81690581
110* primary alcohol metabolic process (GO:0034308)2.81269849
111gap junction assembly (GO:0016264)2.81219754
112tight junction assembly (GO:0070830)2.80810448
113mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.80500771
114regulation of transforming growth factor beta1 production (GO:0032908)2.80326689
115ethanol oxidation (GO:0006069)2.79948634
116sulfur amino acid metabolic process (GO:0000096)2.79881881
117fibrinolysis (GO:0042730)2.79796085
118regulation of chemokine-mediated signaling pathway (GO:0070099)2.78687444
119fibroblast migration (GO:0010761)2.78010728
120establishment of tissue polarity (GO:0007164)2.77187221
121establishment of planar polarity (GO:0001736)2.77187221
122axoneme assembly (GO:0035082)2.74452746
123regulation of integrin-mediated signaling pathway (GO:2001044)2.73972868
124regulation of transforming growth factor beta2 production (GO:0032909)2.73137568
125folic acid transport (GO:0015884)2.71706975
126negative regulation of cholesterol transport (GO:0032375)2.71172078
127negative regulation of sterol transport (GO:0032372)2.71172078
128cellular response to vitamin (GO:0071295)2.70858813
129extracellular fibril organization (GO:0043206)2.70665962
130dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.70582158
131positive regulation of extracellular matrix organization (GO:1903055)2.69807832
132regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.69133750
133pyrimidine ribonucleoside catabolic process (GO:0046133)2.68547979
134lung lobe morphogenesis (GO:0060463)2.67714424
135hippo signaling (GO:0035329)2.66592032
136bile acid metabolic process (GO:0008206)2.66442843
137bile acid and bile salt transport (GO:0015721)2.65788527
1384-hydroxyproline metabolic process (GO:0019471)2.65239674
139purine nucleobase biosynthetic process (GO:0009113)2.64005950
140interferon-gamma secretion (GO:0072643)2.63114196
141regulation of type B pancreatic cell apoptotic process (GO:2000674)2.61809091
142regulation of bile acid biosynthetic process (GO:0070857)2.61742985
143S-adenosylmethionine metabolic process (GO:0046500)2.61241732
144ER overload response (GO:0006983)2.61097411
145one-carbon metabolic process (GO:0006730)2.60699169
146negative regulation of keratinocyte proliferation (GO:0010839)2.59873616
147regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.59869689
148drug transmembrane transport (GO:0006855)2.59840676
149negative regulation of fatty acid biosynthetic process (GO:0045717)2.59486622
150lung vasculature development (GO:0060426)2.59472858
151cellular modified amino acid catabolic process (GO:0042219)2.59225835
152mesenchymal cell differentiation involved in kidney development (GO:0072161)2.59137045
153mesenchymal cell differentiation involved in renal system development (GO:2001012)2.59137045
154lipoprotein metabolic process (GO:0042157)2.59080627
155respiratory tube development (GO:0030323)2.58953743
156eosinophil migration (GO:0072677)2.58681602
157pantothenate metabolic process (GO:0015939)2.57846634
158embryonic foregut morphogenesis (GO:0048617)2.57833730
159vitamin transport (GO:0051180)2.57549895
160embryonic cranial skeleton morphogenesis (GO:0048701)2.55824032
161* retinoic acid metabolic process (GO:0042573)2.54260256
162uronic acid metabolic process (GO:0006063)2.54079267
163glucuronate metabolic process (GO:0019585)2.54079267
164acylglycerol homeostasis (GO:0055090)2.53789867
165triglyceride homeostasis (GO:0070328)2.53789867
166alpha-amino acid catabolic process (GO:1901606)2.52873079
167fat-soluble vitamin metabolic process (GO:0006775)2.52319762
168regulation of metalloenzyme activity (GO:0048552)2.51076948
169positive regulation of protein autophosphorylation (GO:0031954)2.50689229
170positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.50360816
171endocrine hormone secretion (GO:0060986)2.49360883
172positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.48545288
173left/right axis specification (GO:0070986)2.47920859
174positive regulation of endothelial cell apoptotic process (GO:2000353)2.47199550
175hypotonic response (GO:0006971)2.46658557
176bone trabecula formation (GO:0060346)2.45337460
177endocardial cushion development (GO:0003197)2.44717158
178oligosaccharide biosynthetic process (GO:0009312)2.43325574
179regulation of apoptotic process involved in morphogenesis (GO:1902337)2.41699391
180positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.40294259
181regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.40294259
182protein heterotrimerization (GO:0070208)2.39867881
183fibril organization (GO:0097435)2.39740353
184regulation of chondrocyte differentiation (GO:0032330)2.39592217
185protein hydroxylation (GO:0018126)2.39213528
186blood vessel maturation (GO:0001955)2.38297247
187nucleotide-sugar biosynthetic process (GO:0009226)2.37575702

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.91677898
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.37040177
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.73058937
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.12403456
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.94528620
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.63719050
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.59446115
8CLOCK_20551151_ChIP-Seq_293T_Human3.37378409
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.08997271
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.97896331
11AR_21909140_ChIP-Seq_LNCAP_Human2.74769328
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.72057263
13ZNF263_19887448_ChIP-Seq_K562_Human2.61791773
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52128151
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51909512
16* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.44116914
17TP53_18474530_ChIP-ChIP_U2OS_Human2.39920523
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.30721920
19PIAS1_25552417_ChIP-Seq_VCAP_Human2.23365669
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.16558977
21AHR_22903824_ChIP-Seq_MCF-7_Human2.11704836
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.08870819
23ESR1_21235772_ChIP-Seq_MCF-7_Human2.06559173
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04297154
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.03672324
26PPAR_26484153_Chip-Seq_NCI-H1993_Human2.00066349
27ATF3_27146783_Chip-Seq_COLON_Human1.98733348
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.95847662
29FOXM1_26456572_ChIP-Seq_MCF-7_Human1.94818780
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.94737398
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.88554918
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.86135788
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.86128012
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84697062
35CDX2_20551321_ChIP-Seq_CACO-2_Human1.84462670
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.82933746
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.80970860
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.79801493
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.78945951
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78009087
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77908770
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.76921102
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.73717615
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.73717615
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73687329
46* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.73146108
47GATA4_25053715_ChIP-Seq_YYC3_Human1.73013994
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72704919
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.70864036
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.68764953
51TP53_16413492_ChIP-PET_HCT116_Human1.67828983
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63757137
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.63707912
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57885068
55TP63_23658742_ChIP-Seq_EP156T_Human1.55421184
56GATA6_25053715_ChIP-Seq_YYC3_Human1.53970807
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.53070392
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52198700
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.51452452
60SOX2_20726797_ChIP-Seq_SW620_Human1.51216035
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.50235975
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45648884
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45456531
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44988581
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40217485
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.40091361
67VDR_22108803_ChIP-Seq_LS180_Human1.40079413
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38707639
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38665615
70* CDX2_22108803_ChIP-Seq_LS180_Human1.36206295
71RACK7_27058665_Chip-Seq_MCF-7_Human1.36040969
72GBX2_23144817_ChIP-Seq_PC3_Human1.30982742
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29636125
74* CJUN_26792858_Chip-Seq_BT549_Human1.28589078
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.28388242
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27746974
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26280089
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.23034340
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20882912
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20668094
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18453506
82SMAD4_21799915_ChIP-Seq_A2780_Human1.18366521
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17071290
84* EZH2_27294783_Chip-Seq_NPCs_Mouse1.16978121
85CHD1_26751641_Chip-Seq_LNCaP_Human1.16957508
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.16469237
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16334619
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15820810
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15687989
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.14282147
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13946033
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13848174
93* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13823926
94FOXA2_19822575_ChIP-Seq_HepG2_Human1.13242806
95HNF4A_19822575_ChIP-Seq_HepG2_Human1.12123837
96* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11556681
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11151105
98HNFA_21074721_ChIP-Seq_CACO-2_Human1.10573751
99* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10263688
100PHF8_20622853_ChIP-Seq_HELA_Human1.07927094
101FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07443399
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06440539
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05190513
104* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05111608
105* NFE2_27457419_Chip-Seq_LIVER_Mouse1.04979008
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04782625
107TBL1_22424771_ChIP-Seq_293T_Human1.04549037
108TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04422715
109NFYB_21822215_ChIP-Seq_K562_Human1.04362028
110PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04303427
111CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03271947
112P300_19829295_ChIP-Seq_ESCs_Human1.02695602
113GATA3_24758297_ChIP-Seq_MCF-7_Human1.02663293
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02057672
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01740659
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01293081
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00800223
118RUNX1_27514584_Chip-Seq_MCF-7_Human1.00682753
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00154713
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.99075070
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98865291
122TCF4_22108803_ChIP-Seq_LS180_Human0.98803592
123BCAT_22108803_ChIP-Seq_LS180_Human0.97633632
124* NANOG_18555785_Chip-Seq_ESCs_Mouse0.96875703
125SMAD3_21741376_ChIP-Seq_EPCs_Human0.96395738
126ETV1_20927104_ChIP-Seq_GIST48_Human0.96319716
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95963030
128BRD4_25478319_ChIP-Seq_HGPS_Human0.95789457
129* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95658888
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.93676025
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92259442
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.92051844
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89833027
134NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89568473
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88403890
136KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86334410
137TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85625875
138* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85310973
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85127825
140PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83240611
141NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82658629
142ELK1_22589737_ChIP-Seq_MCF10A_Human0.82484687
143NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81594704
144MYC_18555785_ChIP-Seq_MESCs_Mouse0.80840899
145ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79104570
146P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78399295
147ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78045693
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76375375
149FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75709016
150NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74968099
151NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74968099
152AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74815949
153NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74191457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.69727437
2MP0005360_urolithiasis4.03029966
3MP0005503_abnormal_tendon_morphology4.01504305
4MP0003011_delayed_dark_adaptation3.59394519
5MP0003950_abnormal_plasma_membrane3.45608011
6MP0005085_abnormal_gallbladder_physiolo3.40799007
7MP0010234_abnormal_vibrissa_follicle3.09169255
8MP0003252_abnormal_bile_duct2.98702516
9MP0005365_abnormal_bile_salt2.86624259
10MP0003705_abnormal_hypodermis_morpholog2.76963156
11MP0001958_emphysema2.73593606
12MP0000537_abnormal_urethra_morphology2.67744876
13MP0004019_abnormal_vitamin_homeostasis2.58575466
14MP0008875_abnormal_xenobiotic_pharmacok2.52584411
15MP0002138_abnormal_hepatobiliary_system2.30309521
16MP0009840_abnormal_foam_cell2.29643579
17MP0004264_abnormal_extraembryonic_tissu2.28834954
18MP0003941_abnormal_skin_development2.19606847
19MP0003300_gastrointestinal_ulcer2.04017662
20MP0009780_abnormal_chondrocyte_physiolo1.99784026
21MP0003718_maternal_effect1.88346045
22MP0010386_abnormal_urinary_bladder1.86615144
23MP0009053_abnormal_anal_canal1.85577524
24MP0005332_abnormal_amino_acid1.81949946
25MP0005508_abnormal_skeleton_morphology1.75470492
26MP0001666_abnormal_nutrient_absorption1.74952591
27MP0002876_abnormal_thyroid_physiology1.70954444
28MP0003279_aneurysm1.69374947
29MP0010329_abnormal_lipoprotein_level1.68046928
30MP0002877_abnormal_melanocyte_morpholog1.65874956
31MP0010368_abnormal_lymphatic_system1.65169797
32MP0005164_abnormal_response_to1.62668669
33MP0002295_abnormal_pulmonary_circulatio1.61296514
34MP0002896_abnormal_bone_mineralization1.60751571
35MP0005408_hypopigmentation1.58700840
36MP0005451_abnormal_body_composition1.48659418
37MP0001849_ear_inflammation1.47268829
38MP0006054_spinal_hemorrhage1.46832224
39MP0009384_cardiac_valve_regurgitation1.46484054
40MP0005248_abnormal_Harderian_gland1.45947359
41MP0005257_abnormal_intraocular_pressure1.44742917
42MP0003806_abnormal_nucleotide_metabolis1.40390308
43MP0004272_abnormal_basement_membrane1.38814626
44MP0003828_pulmonary_edema1.35217682
45MP0005395_other_phenotype1.34799276
46MP0005220_abnormal_exocrine_pancreas1.31880421
47MP0001542_abnormal_bone_strength1.31205749
48MP0001661_extended_life_span1.30939268
49MP0003091_abnormal_cell_migration1.28850959
50MP0003453_abnormal_keratinocyte_physiol1.27840059
51MP0000609_abnormal_liver_physiology1.26471304
52MP0009643_abnormal_urine_homeostasis1.25234044
53MP0005023_abnormal_wound_healing1.25153921
54MP0010352_gastrointestinal_tract_polyps1.24932084
55MP0002108_abnormal_muscle_morphology1.23306319
56MP0005084_abnormal_gallbladder_morpholo1.18784012
57MP0005275_abnormal_skin_tensile1.16722862
58MP0000762_abnormal_tongue_morphology1.16655990
59MP0001299_abnormal_eye_distance/1.15206892
60MP0009250_abnormal_appendicular_skeleto1.14092578
61MP0005377_hearing/vestibular/ear_phenot1.09223489
62MP0003878_abnormal_ear_physiology1.09223489
63MP0002060_abnormal_skin_morphology1.07736236
64MP0008438_abnormal_cutaneous_collagen1.07269937
65* MP0002233_abnormal_nose_morphology1.05663511
66MP0003868_abnormal_feces_composition1.04553901
67MP0002928_abnormal_bile_duct1.04281505
68MP0003283_abnormal_digestive_organ1.02465606
69MP0003693_abnormal_embryo_hatching1.02205025
70MP0001270_distended_abdomen1.01957771
71MP0000163_abnormal_cartilage_morphology1.01685051
72MP0003566_abnormal_cell_adhesion1.00428395
73MP0000477_abnormal_intestine_morphology0.99993775
74MP0003195_calcinosis0.99404718
75MP0005187_abnormal_penis_morphology0.98239921
76MP0005165_increased_susceptibility_to0.97380481
77MP0003315_abnormal_perineum_morphology0.97200116
78MP0002282_abnormal_trachea_morphology0.97054799
79MP0010678_abnormal_skin_adnexa0.97010227
80MP0000627_abnormal_mammary_gland0.95571104
81* MP0003115_abnormal_respiratory_system0.95164031
82MP0001243_abnormal_dermal_layer0.94609429
83MP0005319_abnormal_enzyme/_coenzyme0.94010604
84MP0005167_abnormal_blood-brain_barrier0.93089135
85MP0006082_CNS_inflammation0.92352444
86MP0000003_abnormal_adipose_tissue0.92040028
87* MP0002092_abnormal_eye_morphology0.91236672
88MP0003755_abnormal_palate_morphology0.91166307
89MP0010030_abnormal_orbit_morphology0.90597669
90* MP0003937_abnormal_limbs/digits/tail_de0.89699857
91MP0000467_abnormal_esophagus_morphology0.89246400
92MP0001879_abnormal_lymphatic_vessel0.88617863
93MP0002102_abnormal_ear_morphology0.87844339
94MP0002132_abnormal_respiratory_system0.87488032
95MP0002254_reproductive_system_inflammat0.87383200
96MP0004957_abnormal_blastocyst_morpholog0.86227569
97MP0000427_abnormal_hair_cycle0.86163057
98MP0002168_other_aberrant_phenotype0.86153963
99MP0005501_abnormal_skin_physiology0.86081120
100MP0001915_intracranial_hemorrhage0.85913514
101MP0000681_abnormal_thyroid_gland0.85781034
102MP0000534_abnormal_ureter_morphology0.85630308
103* MP0000598_abnormal_liver_morphology0.85424600
104* MP0000432_abnormal_head_morphology0.84913999
105MP0000013_abnormal_adipose_tissue0.84346778
106MP0005623_abnormal_meninges_morphology0.83947476
107MP0010307_abnormal_tumor_latency0.82816821
108MP0002234_abnormal_pharynx_morphology0.82249507
109MP0000767_abnormal_smooth_muscle0.81387407
110MP0000733_abnormal_muscle_development0.80738502
111MP0005595_abnormal_vascular_smooth0.80367507
112MP0002136_abnormal_kidney_physiology0.79268674
113MP0000462_abnormal_digestive_system0.78899284
114MP0000613_abnormal_salivary_gland0.78737647
115MP0002796_impaired_skin_barrier0.78649208
116MP0002098_abnormal_vibrissa_morphology0.78613156
117MP0005083_abnormal_biliary_tract0.78425333
118MP0003191_abnormal_cellular_cholesterol0.78405822
119* MP0002115_abnormal_skeleton_extremities0.78317067
120MP0000383_abnormal_hair_follicle0.78164329
121MP0002133_abnormal_respiratory_system0.77478966
122MP0005388_respiratory_system_phenotype0.77478966
123MP0002086_abnormal_extraembryonic_tissu0.77227920
124* MP0003942_abnormal_urinary_system0.76950706
125MP0000377_abnormal_hair_follicle0.76768213
126MP0006138_congestive_heart_failure0.75796430
127MP0002118_abnormal_lipid_homeostasis0.75440590
128MP0001756_abnormal_urination0.75307006
129MP0000749_muscle_degeneration0.74918811
130MP0004134_abnormal_chest_morphology0.74874173
131MP0001216_abnormal_epidermal_layer0.74049530
132MP0001324_abnormal_eye_pigmentation0.73039060
133MP0001881_abnormal_mammary_gland0.72741465
134MP0010155_abnormal_intestine_physiology0.70156601
135MP0004043_abnormal_pH_regulation0.69763391
136* MP0002128_abnormal_blood_circulation0.69189148
137MP0002249_abnormal_larynx_morphology0.68461159
138MP0002160_abnormal_reproductive_system0.67929882
139MP0000049_abnormal_middle_ear0.67476948
140* MP0002135_abnormal_kidney_morphology0.67447493
141MP0000490_abnormal_crypts_of0.66766382
142MP0003186_abnormal_redox_activity0.66630885
143MP0001730_embryonic_growth_arrest0.65524015
144MP0000538_abnormal_urinary_bladder0.64554005
145MP0001672_abnormal_embryogenesis/_devel0.64466433
146MP0005380_embryogenesis_phenotype0.64466433
147MP0004883_abnormal_blood_vessel0.63499848
148MP0001764_abnormal_homeostasis0.61115382
149MP0003984_embryonic_growth_retardation0.60828918
150* MP0005193_abnormal_anterior_eye0.60705576
151MP0005197_abnormal_uvea_morphology0.60690307

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.69184357
2Deep venous thrombosis (HP:0002625)4.80557124
3Rhinitis (HP:0012384)4.51123624
4Abnormal respiratory motile cilium physiology (HP:0012261)4.43681983
5Gout (HP:0001997)4.23516709
6Abnormal respiratory motile cilium morphology (HP:0005938)4.22727651
7Abnormal respiratory epithelium morphology (HP:0012253)4.22727651
8Absent/shortened dynein arms (HP:0200106)4.14557947
9Dynein arm defect of respiratory motile cilia (HP:0012255)4.14557947
10Abnormal ciliary motility (HP:0012262)4.04521423
11Intrahepatic cholestasis (HP:0001406)3.93644295
12Chronic bronchitis (HP:0004469)3.90017695
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.81233413
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.79347546
15Xanthomatosis (HP:0000991)3.75568844
16Soft skin (HP:0000977)3.70919338
17Hyperglycinemia (HP:0002154)3.61796708
18Protrusio acetabuli (HP:0003179)3.58820617
19Focal segmental glomerulosclerosis (HP:0000097)3.53687924
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.48137447
21Hyperglycinuria (HP:0003108)3.46062575
22Hypobetalipoproteinemia (HP:0003563)3.44183428
23Bronchiectasis (HP:0002110)3.21361492
24Follicular hyperkeratosis (HP:0007502)3.16612433
25Glomerulosclerosis (HP:0000096)3.14952756
26Short nail (HP:0001799)3.13127209
27Abnormality of glycine metabolism (HP:0010895)3.11689411
28Abnormality of serine family amino acid metabolism (HP:0010894)3.11689411
29Spondylolisthesis (HP:0003302)3.02943709
30Esophageal varix (HP:0002040)3.00349918
31Premature rupture of membranes (HP:0001788)2.95129941
32Onycholysis (HP:0001806)2.88856224
33Chorioretinal atrophy (HP:0000533)2.80480938
34Abnormality of the common coagulation pathway (HP:0010990)2.77841724
35Spastic diplegia (HP:0001264)2.75283882
36Micronodular cirrhosis (HP:0001413)2.74075223
37Hepatocellular carcinoma (HP:0001402)2.73654125
38Atrophic scars (HP:0001075)2.70352539
39Abnormality of purine metabolism (HP:0004352)2.69052266
40Subacute progressive viral hepatitis (HP:0006572)2.68892391
41Hypolipoproteinemia (HP:0010981)2.64814573
42Nasal polyposis (HP:0100582)2.64699769
43Abnormality of proline metabolism (HP:0010907)2.64534595
44Hydroxyprolinuria (HP:0003080)2.64534595
45Myocardial infarction (HP:0001658)2.62830333
46Abnormality of dentin (HP:0010299)2.58655549
47Cardiovascular calcification (HP:0011915)2.58594030
48Hyperuricemia (HP:0002149)2.57342447
49Increased purine levels (HP:0004368)2.57342447
50Vascular calcification (HP:0004934)2.57285746
51Alopecia of scalp (HP:0002293)2.52028905
52Vertebral compression fractures (HP:0002953)2.52028633
53Bladder diverticulum (HP:0000015)2.51649378
54Mitral stenosis (HP:0001718)2.48875447
55Decreased electroretinogram (ERG) amplitude (HP:0000654)2.47034267
56Wormian bones (HP:0002645)2.46463711
57Pustule (HP:0200039)2.46400606
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.46378181
59Abnormality of the distal phalanges of the toes (HP:0010182)2.46328944
60Aortic aneurysm (HP:0004942)2.44567236
61Abnormality of the intrinsic pathway (HP:0010989)2.43951324
62Hyperactive renin-angiotensin system (HP:0000841)2.43692568
63Tubular atrophy (HP:0000092)2.37530614
64Complement deficiency (HP:0004431)2.37081657
65Polycythemia (HP:0001901)2.33481886
66Arterial tortuosity (HP:0005116)2.32117728
67Abnormality of nucleobase metabolism (HP:0010932)2.31533640
68Hypoalphalipoproteinemia (HP:0003233)2.30858188
69Hyperammonemia (HP:0001987)2.29764120
70Bell-shaped thorax (HP:0001591)2.28960553
71Spontaneous abortion (HP:0005268)2.28557474
72Dilatation of the ascending aorta (HP:0005111)2.28079053
73Hyperlipoproteinemia (HP:0010980)2.20979210
74Epidermoid cyst (HP:0200040)2.20514855
75Abnormality of the nasal mucosa (HP:0000433)2.20019418
76Ankle contracture (HP:0006466)2.17763292
77Abnormality of the frontal sinuses (HP:0002687)2.16958495
78Cervical subluxation (HP:0003308)2.16784030
79Aortic dissection (HP:0002647)2.16316786
80Vascular tortuosity (HP:0004948)2.15553469
81Shallow orbits (HP:0000586)2.14010184
82Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13610520
83Prolonged partial thromboplastin time (HP:0003645)2.10908967
84Bronchitis (HP:0012387)2.09770871
85Fat malabsorption (HP:0002630)2.09718066
86Knee flexion contracture (HP:0006380)2.06151316
87Cutaneous melanoma (HP:0012056)2.05826645
88Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.05604347
89Abnormal cartilage morphology (HP:0002763)2.03950013
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02885162
91Osteolytic defects of the hand bones (HP:0009699)2.01271029
92Osteolytic defects of the phalanges of the hand (HP:0009771)2.01271029
93Abnormality of midbrain morphology (HP:0002418)2.01195330
94Molar tooth sign on MRI (HP:0002419)2.01195330
95Right ventricular cardiomyopathy (HP:0011663)2.01181558
96Mitral valve prolapse (HP:0001634)1.99588039
97Abnormality of serum amino acid levels (HP:0003112)1.99558426
98Broad metatarsal (HP:0001783)1.99026210
99Interstitial pulmonary disease (HP:0006530)1.98616836
100Milia (HP:0001056)1.98091645
101Aortic regurgitation (HP:0001659)1.96191093
102Occipital encephalocele (HP:0002085)1.96055046
103Hyperglycemia (HP:0003074)1.96033905
104Hypoplasia of the odontoid process (HP:0003311)1.94269950
105Abnormal delivery (HP:0001787)1.91467853
106Abnormality of the acetabulum (HP:0003170)1.90253944
107Joint hemorrhage (HP:0005261)1.90070076
108Absent frontal sinuses (HP:0002688)1.89870506
109Blue sclerae (HP:0000592)1.88548792
110True hermaphroditism (HP:0010459)1.87958115
111Ileus (HP:0002595)1.87764751
112Corneal dystrophy (HP:0001131)1.86085043
113Malnutrition (HP:0004395)1.84058695
114Striae distensae (HP:0001065)1.83966535
115Male infertility (HP:0003251)1.83358541
116Aneurysm (HP:0002617)1.82287531
117Lymphangioma (HP:0100764)1.81970395
118Acanthocytosis (HP:0001927)1.79744269
119Bifid tongue (HP:0010297)1.77251363
120Ovoid vertebral bodies (HP:0003300)1.75983529
121Hypoglycemic coma (HP:0001325)1.75972334
122Biliary tract neoplasm (HP:0100574)1.75730974
123Rectal prolapse (HP:0002035)1.75391146
124Radial bowing (HP:0002986)1.75184109
125Cone-rod dystrophy (HP:0000548)1.74804546
126Long toe (HP:0010511)1.74336240
127Infertility (HP:0000789)1.73956690
128Abnormal pancreas size (HP:0012094)1.73382976
129Hypothermia (HP:0002045)1.72179348
130Coronal craniosynostosis (HP:0004440)1.71986738
131Pancreatic fibrosis (HP:0100732)1.71022730
132Pancreatic cysts (HP:0001737)1.70943487
133Hypercholesterolemia (HP:0003124)1.69876012
134Enlarged penis (HP:0000040)1.68469502
135Abnormality of complement system (HP:0005339)1.68250619
136Spinal rigidity (HP:0003306)1.68247838
137Aortic valve stenosis (HP:0001650)1.67719126
138Gingival overgrowth (HP:0000212)1.67495314
139Lip pit (HP:0100267)1.66234373
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.66108324
141Peritonitis (HP:0002586)1.65475474
142Hyperextensible skin (HP:0000974)1.64390800
143Hyperkalemia (HP:0002153)1.63874857
144Fragile skin (HP:0001030)1.63609900
145Abnormalities of placenta or umbilical cord (HP:0001194)1.63592969
146Atelectasis (HP:0100750)1.63335563
147Posterior subcapsular cataract (HP:0007787)1.63059449
148Skin nodule (HP:0200036)1.62039023
149Joint laxity (HP:0001388)1.61728990
150Redundant skin (HP:0001582)1.61709439
151Abnormal tarsal ossification (HP:0008369)1.61589543
152Bowed forearm bones (HP:0003956)1.61409513
153Bowing of the arm (HP:0006488)1.61409513
154Abnormality of the fetal cardiovascular system (HP:0010948)1.61312050
155Abnormal umbilical cord blood vessels (HP:0011403)1.61312050
156Single umbilical artery (HP:0001195)1.61312050
157Biconcave vertebral bodies (HP:0004586)1.60927373
158Elbow flexion contracture (HP:0002987)1.60459057
159Hypokalemic alkalosis (HP:0001949)1.60417872
160Bowel diverticulosis (HP:0005222)1.60253341
161Neonatal short-limb short stature (HP:0008921)1.59651007
162Hypopigmentation of the fundus (HP:0007894)1.58435143
163Fragile nails (HP:0001808)1.58421237
164Back pain (HP:0003418)1.58354660
165Ulnar bowing (HP:0003031)1.58172922
166Abnormality of methionine metabolism (HP:0010901)1.57301411
167Exocrine pancreatic insufficiency (HP:0001738)1.56703026
168Hypoplastic labia majora (HP:0000059)1.56505301
169Beaking of vertebral bodies (HP:0004568)1.54232440
170Flared iliac wings (HP:0002869)1.53110342
171Tubulointerstitial fibrosis (HP:0005576)1.52977051
172Glucose intolerance (HP:0000833)1.51177734
173Tetraparesis (HP:0002273)1.50935767
174Median cleft lip (HP:0000161)1.50757743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.30580615
2LATS14.62144712
3MYLK3.70917026
4STK38L3.11903303
5STK392.82206485
6NUAK12.70610720
7MST42.66340643
8BCR2.66039799
9TRIM282.47436655
10TRIB32.36620252
11LATS22.35970981
12PKN22.27386479
13EIF2AK12.17596191
14STK32.16998041
15EIF2AK32.15105726
16AKT32.09087520
17MAP3K122.06108606
18ERBB31.99921750
19FRK1.88444630
20PTK61.74392768
21GRK11.71282482
22PAK41.69882593
23SIK31.69687670
24OXSR11.64610406
25EPHB21.58814692
26TRPM71.56745399
27TGFBR21.54422258
28BCKDK1.52915008
29ERBB41.52857781
30MAPKAPK31.49843957
31FER1.49477458
32ERN11.48824763
33EEF2K1.47355889
34BMPR21.47328453
35LRRK21.46232116
36PTK21.45777217
37MAPK151.44365096
38RPS6KA41.44067770
39STK101.43066537
40FGFR41.42801280
41MAP3K71.42642136
42MAP2K21.39377744
43MST1R1.37614679
44DDR21.37396264
45PIK3CA1.30487630
46RPS6KB21.30475975
47NEK21.29435797
48CDK81.29091011
49PDK21.24971473
50CASK1.24078480
51BMPR1B1.23663925
52NEK91.23431739
53PDGFRA1.20079020
54CDK61.18547736
55TAOK31.18315150
56PIK3CG1.13388334
57BRSK21.10012913
58STK161.08791314
59STK381.07327714
60TXK1.06435440
61WNK11.06234871
62WEE11.05193769
63TGFBR11.04157176
64WNK41.03859647
65CSNK1G11.02598543
66STK240.99910944
67RAF10.98540930
68MAP3K30.98424310
69CSNK1A1L0.98347665
70SIK10.97910862
71NME20.96958726
72MELK0.96778228
73DYRK30.93417465
74TTK0.92828168
75MAP2K10.91489617
76ROCK10.90357925
77TTN0.89910483
78MAP3K80.87856175
79DMPK0.86505867
80FGFR20.84779140
81SCYL20.82650369
82MOS0.81502853
83TAOK10.80988566
84ADRBK10.80529631
85PAK20.80120883
86ADRBK20.79927889
87CDK40.78793776
88FLT30.77233228
89TNIK0.77090028
90PRKCE0.76999333
91PRKCI0.76981174
92AURKB0.71967645
93NTRK10.71392092
94CSNK1G30.70860263
95DYRK1B0.70358405
96ABL20.70190231
97NLK0.68744957
98BUB10.67316401
99CDK90.66848152
100TESK10.66710366
101FGFR30.65442434
102MET0.63724831
103PTK2B0.63296862
104PDGFRB0.63033873
105PRKG20.62967190
106TIE10.62921435
107RIPK10.62606361
108MTOR0.62524257
109PBK0.60474696
110CSNK1G20.55509200
111GRK70.53944865
112KSR20.51401166
113FGFR10.50979738
114GSK3A0.46436275
115CHUK0.46425476
116PRKD20.44037454
117PNCK0.43858989
118PAK30.42587883
119PLK10.41862201
120MAP2K30.41245220
121CHEK20.41169409
122GRK50.41059939
123ACVR1B0.40172913
124PLK40.39865572
125PIM20.39359980
126ERBB20.38966301
127NME10.37671575
128PLK30.37228321
129MAPKAPK50.37024929
130PLK20.36749805
131MAP3K20.35245232
132MAP3K130.35131488
133MAPK110.35021139
134ABL10.34486394
135NEK60.33554195
136AKT20.33340925
137PRKAA20.32299891
138ROCK20.30991387
139ILK0.30902845
140KSR10.30692261
141IRAK30.30511414
142EPHA30.30399705
143BMX0.30387728
144LMTK20.30379147
145MAP3K100.29824498
146LIMK10.29340549
147BRSK10.27949950
148IGF1R0.27764541
149NEK10.27557444
150MKNK20.27321649
151PRKAA10.25970323

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44221215
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.04892243
3Nitrogen metabolism_Homo sapiens_hsa009102.81597707
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48385599
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.32107425
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30378444
7Fatty acid degradation_Homo sapiens_hsa000712.23061056
8Complement and coagulation cascades_Homo sapiens_hsa046102.14987693
9Arginine biosynthesis_Homo sapiens_hsa002202.05447327
10Vitamin B6 metabolism_Homo sapiens_hsa007501.94875451
11Protein export_Homo sapiens_hsa030601.85010004
12Tryptophan metabolism_Homo sapiens_hsa003801.81279328
13* Retinol metabolism_Homo sapiens_hsa008301.80680332
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80087206
15Folate biosynthesis_Homo sapiens_hsa007901.79025704
16Vitamin digestion and absorption_Homo sapiens_hsa049771.77627498
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77600705
18Chemical carcinogenesis_Homo sapiens_hsa052041.75938058
19Butanoate metabolism_Homo sapiens_hsa006501.72751743
20Selenocompound metabolism_Homo sapiens_hsa004501.65773547
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65470121
22Sphingolipid metabolism_Homo sapiens_hsa006001.63941320
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61867364
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.58562538
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54821590
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54466418
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53069882
28Caffeine metabolism_Homo sapiens_hsa002321.44714824
29Bile secretion_Homo sapiens_hsa049761.44407307
30Peroxisome_Homo sapiens_hsa041461.44309701
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43766761
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.42266725
33Histidine metabolism_Homo sapiens_hsa003401.42132867
34Small cell lung cancer_Homo sapiens_hsa052221.39784149
35beta-Alanine metabolism_Homo sapiens_hsa004101.39517178
36PPAR signaling pathway_Homo sapiens_hsa033201.31259562
37Fatty acid metabolism_Homo sapiens_hsa012121.31137572
38Sulfur metabolism_Homo sapiens_hsa009201.30823468
39Glutathione metabolism_Homo sapiens_hsa004801.28086646
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25711151
41Bladder cancer_Homo sapiens_hsa052191.24827002
42Biosynthesis of amino acids_Homo sapiens_hsa012301.23002784
43Galactose metabolism_Homo sapiens_hsa000521.22290641
44Adherens junction_Homo sapiens_hsa045201.21804716
45Tyrosine metabolism_Homo sapiens_hsa003501.21634600
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.17392850
47Pentose phosphate pathway_Homo sapiens_hsa000301.12971907
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.12159438
49Pyruvate metabolism_Homo sapiens_hsa006201.11807898
50Hedgehog signaling pathway_Homo sapiens_hsa043401.08273143
51ECM-receptor interaction_Homo sapiens_hsa045121.08247909
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06092695
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03895515
54Carbon metabolism_Homo sapiens_hsa012001.02845496
55Fat digestion and absorption_Homo sapiens_hsa049751.02793592
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.02743371
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02041654
58Propanoate metabolism_Homo sapiens_hsa006401.01676695
59p53 signaling pathway_Homo sapiens_hsa041151.01531212
60Arginine and proline metabolism_Homo sapiens_hsa003301.00440760
61N-Glycan biosynthesis_Homo sapiens_hsa005100.98638487
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.94504733
63Proteasome_Homo sapiens_hsa030500.90532960
64Hippo signaling pathway_Homo sapiens_hsa043900.86930291
65Staphylococcus aureus infection_Homo sapiens_hsa051500.83336327
66Fructose and mannose metabolism_Homo sapiens_hsa000510.83262259
67Vibrio cholerae infection_Homo sapiens_hsa051100.79683935
68Phenylalanine metabolism_Homo sapiens_hsa003600.79601203
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79508880
70Starch and sucrose metabolism_Homo sapiens_hsa005000.79033030
71Sulfur relay system_Homo sapiens_hsa041220.77514431
72Thyroid cancer_Homo sapiens_hsa052160.74990067
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74199957
74Tight junction_Homo sapiens_hsa045300.73176490
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72515408
76Renin-angiotensin system_Homo sapiens_hsa046140.71236571
77Proteoglycans in cancer_Homo sapiens_hsa052050.70356842
78TGF-beta signaling pathway_Homo sapiens_hsa043500.69112760
79Cell cycle_Homo sapiens_hsa041100.68991467
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68700324
81Steroid biosynthesis_Homo sapiens_hsa001000.68563062
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67284566
83Basal cell carcinoma_Homo sapiens_hsa052170.67110376
84Lysine degradation_Homo sapiens_hsa003100.66558530
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63635133
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61369126
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61075401
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60453733
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.59757922
90Focal adhesion_Homo sapiens_hsa045100.59611328
91Chronic myeloid leukemia_Homo sapiens_hsa052200.59521488
92MicroRNAs in cancer_Homo sapiens_hsa052060.59484310
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59409898
94Pancreatic cancer_Homo sapiens_hsa052120.58227296
95Mineral absorption_Homo sapiens_hsa049780.57921107
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54699764
97Endometrial cancer_Homo sapiens_hsa052130.51990839
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50194150
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.48898168
100Linoleic acid metabolism_Homo sapiens_hsa005910.48205057
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47793666
102Glycerolipid metabolism_Homo sapiens_hsa005610.47324388
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46976711
104Arachidonic acid metabolism_Homo sapiens_hsa005900.46491548
105Prostate cancer_Homo sapiens_hsa052150.45329692
106Regulation of autophagy_Homo sapiens_hsa041400.44954802
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44344404
108Pathways in cancer_Homo sapiens_hsa052000.42793956
109ABC transporters_Homo sapiens_hsa020100.40859204
110One carbon pool by folate_Homo sapiens_hsa006700.40718947
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38895187
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38450346
113Thyroid hormone synthesis_Homo sapiens_hsa049180.37937124
114Wnt signaling pathway_Homo sapiens_hsa043100.36174316
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35005996
116Fatty acid elongation_Homo sapiens_hsa000620.34922857
117Amoebiasis_Homo sapiens_hsa051460.34816829
118* Metabolic pathways_Homo sapiens_hsa011000.34086923
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33134326
120African trypanosomiasis_Homo sapiens_hsa051430.32796951
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31945895
122Pancreatic secretion_Homo sapiens_hsa049720.31242100
123TNF signaling pathway_Homo sapiens_hsa046680.30604696
124RNA transport_Homo sapiens_hsa030130.30399354
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30142633
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29231127
127Melanoma_Homo sapiens_hsa052180.27840892
128Protein digestion and absorption_Homo sapiens_hsa049740.27471653
129Circadian rhythm_Homo sapiens_hsa047100.26806122
130AMPK signaling pathway_Homo sapiens_hsa041520.26521337
131Insulin resistance_Homo sapiens_hsa049310.24105331
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24104068
133FoxO signaling pathway_Homo sapiens_hsa040680.23819941

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