RDH12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 13 and Retinitis Pigmentosa 53. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)9.20451553
2detection of light stimulus involved in sensory perception (GO:0050962)9.12641184
3detection of light stimulus involved in visual perception (GO:0050908)9.12641184
4* photoreceptor cell maintenance (GO:0045494)8.94452570
5photoreceptor cell development (GO:0042461)8.82631284
6eye photoreceptor cell development (GO:0042462)8.55001024
7multicellular organismal water homeostasis (GO:0050891)8.39336510
8positive regulation of guanylate cyclase activity (GO:0031284)7.51615387
9* phototransduction (GO:0007602)7.20698135
10peptide cross-linking (GO:0018149)7.18604364
11epidermal cell differentiation (GO:0009913)7.12520268
12* detection of light stimulus (GO:0009583)7.10663938
13* phototransduction, visible light (GO:0007603)7.02437478
14* detection of visible light (GO:0009584)7.02352093
15water homeostasis (GO:0030104)6.98176435
16retinal rod cell development (GO:0046548)6.91517964
17GMP metabolic process (GO:0046037)6.79491647
18regulation of guanylate cyclase activity (GO:0031282)6.71334350
19photoreceptor cell differentiation (GO:0046530)6.47022490
20eye photoreceptor cell differentiation (GO:0001754)6.47022490
21* visual perception (GO:0007601)6.44296500
22* sensory perception of light stimulus (GO:0050953)6.38831392
23epidermis development (GO:0008544)6.15355940
24intermediate filament organization (GO:0045109)6.00392261
25cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.64379557
26protein-chromophore linkage (GO:0018298)5.62052548
27linoleic acid metabolic process (GO:0043651)5.38042920
28cellular response to antibiotic (GO:0071236)5.30092337
29cellular response to light stimulus (GO:0071482)5.21593015
30phosphatidylserine acyl-chain remodeling (GO:0036150)5.15670503
31lipoxygenase pathway (GO:0019372)5.12415859
32bundle of His cell to Purkinje myocyte communication (GO:0086069)5.06635290
33retina development in camera-type eye (GO:0060041)5.03069391
34* detection of external stimulus (GO:0009581)5.01219341
35C21-steroid hormone biosynthetic process (GO:0006700)4.97351455
36* detection of abiotic stimulus (GO:0009582)4.95473057
37phosphatidylinositol acyl-chain remodeling (GO:0036149)4.91738787
38regulation of cGMP metabolic process (GO:0030823)4.83316803
39intermediate filament cytoskeleton organization (GO:0045104)4.79717929
40cell morphogenesis involved in neuron differentiation (GO:0048667)4.72771387
41response to phenylpropanoid (GO:0080184)4.66152810
42intermediate filament-based process (GO:0045103)4.61051751
43androgen biosynthetic process (GO:0006702)4.60193816
44positive regulation of cGMP biosynthetic process (GO:0030828)4.48553845
45response to follicle-stimulating hormone (GO:0032354)4.44984985
46gap junction assembly (GO:0016264)4.38506501
47nonmotile primary cilium assembly (GO:0035058)4.33050675
48glucocorticoid biosynthetic process (GO:0006704)4.29704838
49phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.26568952
50phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.19897192
51progesterone metabolic process (GO:0042448)4.16527099
52regulation of cGMP biosynthetic process (GO:0030826)4.16329964
53desmosome organization (GO:0002934)4.11053617
54glucocorticoid metabolic process (GO:0008211)4.08881986
55phosphatidylcholine acyl-chain remodeling (GO:0036151)4.02383260
56phospholipid efflux (GO:0033700)3.99383985
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.96675432
58positive regulation of cGMP metabolic process (GO:0030825)3.94970357
59regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.80774249
60adaptation of signaling pathway (GO:0023058)3.77642341
61cellular response to toxic substance (GO:0097237)3.72399323
62phosphorylated carbohydrate dephosphorylation (GO:0046838)3.68301587
63inositol phosphate dephosphorylation (GO:0046855)3.68301587
64retina layer formation (GO:0010842)3.51854477
65behavioral response to ethanol (GO:0048149)3.51156714
66skin morphogenesis (GO:0043589)3.50818627
67L-ascorbic acid metabolic process (GO:0019852)3.50321147
68cellular response to radiation (GO:0071478)3.47789256
69Leydig cell differentiation (GO:0033327)3.44025259
70chemosensory behavior (GO:0007635)3.41584973
71C21-steroid hormone metabolic process (GO:0008207)3.40307214
72phospholipid catabolic process (GO:0009395)3.38121562
73arachidonic acid secretion (GO:0050482)3.35918521
74icosanoid secretion (GO:0032309)3.35918521
75short-term memory (GO:0007614)3.35470542
76receptor guanylyl cyclase signaling pathway (GO:0007168)3.34632327
77* sensory perception (GO:0007600)3.32745500
78cellular response to gonadotropin stimulus (GO:0071371)3.32117380
79protein heterotetramerization (GO:0051290)3.30863138
80detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.30354247
81inositol phosphate catabolic process (GO:0071545)3.26646855
82platelet dense granule organization (GO:0060155)3.25772768
83sphingoid metabolic process (GO:0046519)3.25514243
84negative regulation of interferon-gamma production (GO:0032689)3.24659256
85regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.23746958
86regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.23746958
87regulation of cholesterol homeostasis (GO:2000188)3.22023520
88parturition (GO:0007567)3.21406062
89positive regulation of glomerulus development (GO:0090193)3.20718511
90regulation of voltage-gated calcium channel activity (GO:1901385)3.19841634
913-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.17498957
92purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.17498957
93cellular response to cadmium ion (GO:0071276)3.16383600
94phosphatidylserine metabolic process (GO:0006658)3.16090596
95inositol metabolic process (GO:0006020)3.15231294
96transepithelial transport (GO:0070633)3.13043455
97response to insecticide (GO:0017085)3.12412061
98hair follicle morphogenesis (GO:0031069)3.12270688
99regulation of natural killer cell differentiation (GO:0032823)3.08494533
100hemidesmosome assembly (GO:0031581)3.07525247
101keratinocyte development (GO:0003334)3.05126453
102cullin deneddylation (GO:0010388)3.04728908
103regulation of penile erection (GO:0060405)3.04605971
104response to histamine (GO:0034776)3.03025110
105estrogen biosynthetic process (GO:0006703)2.98793786
106hormone biosynthetic process (GO:0042446)2.97538324
107ectoderm development (GO:0007398)2.97475720
108retina homeostasis (GO:0001895)2.93149023
109protein localization to synapse (GO:0035418)2.92553408
110positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.91502005
111benzene-containing compound metabolic process (GO:0042537)2.90272861
112long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.86191448
113negative regulation of interleukin-17 production (GO:0032700)2.84951216
114primary alcohol catabolic process (GO:0034310)2.83850860
115protein prenylation (GO:0018342)2.82833334
116prenylation (GO:0097354)2.82833334
117vitamin transmembrane transport (GO:0035461)2.82682858
118epithelium development (GO:0060429)2.79120885
119positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.78071466
120fatty acid elongation (GO:0030497)2.77989431
121positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75545491
122neuron development (GO:0048666)2.74950255
123ceramide biosynthetic process (GO:0046513)2.74231251
124positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.73648836
125androgen metabolic process (GO:0008209)2.73398737
126icosanoid transport (GO:0071715)2.72641663
127fatty acid derivative transport (GO:1901571)2.72641663
128righting reflex (GO:0060013)2.72107183
129synaptic transmission, dopaminergic (GO:0001963)2.69795828
130endosome organization (GO:0007032)2.66675069
131fibrinolysis (GO:0042730)2.66002544
132alditol phosphate metabolic process (GO:0052646)2.65666048
133surfactant homeostasis (GO:0043129)2.64925639
134* response to light stimulus (GO:0009416)2.63704907
135very long-chain fatty acid metabolic process (GO:0000038)2.63603129
136chemical homeostasis within a tissue (GO:0048875)2.62127724
137retinal metabolic process (GO:0042574)2.61864698
138regulation of bile acid biosynthetic process (GO:0070857)2.61864679
139behavioral response to cocaine (GO:0048148)2.61191342
140establishment of skin barrier (GO:0061436)2.59705979
141regulation of neuron projection regeneration (GO:0070570)2.59134458
142regulation of axon regeneration (GO:0048679)2.59134458
143negative regulation of mast cell activation (GO:0033004)2.59132890
144response to methylmercury (GO:0051597)2.58690433
145cholesterol efflux (GO:0033344)2.58214051
146vitamin A metabolic process (GO:0006776)2.57349867
147fatty-acyl-CoA biosynthetic process (GO:0046949)2.56714319
148epithelial cell differentiation involved in prostate gland development (GO:0060742)2.54578332
149positive regulation of cholesterol efflux (GO:0010875)2.52998446
150long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.52642015
151bile acid biosynthetic process (GO:0006699)2.52570472
152long-chain fatty acid biosynthetic process (GO:0042759)2.50955620
153keratinization (GO:0031424)2.50389266
154sphingosine metabolic process (GO:0006670)2.50269501
155sensory perception of smell (GO:0007608)2.49169465
156detection of bacterium (GO:0016045)2.47167367
157regulation of phospholipase A2 activity (GO:0032429)2.47015900
158keratinocyte proliferation (GO:0043616)2.45226852
159positive regulation of neurotransmitter transport (GO:0051590)2.43830990
160positive regulation of sodium ion transmembrane transport (GO:1902307)2.42586562
161detection of other organism (GO:0098543)2.40608729
162negative regulation of receptor-mediated endocytosis (GO:0048261)2.37302043
163histone H3-K4 trimethylation (GO:0080182)2.34388831
164diol metabolic process (GO:0034311)2.34361572
165superoxide anion generation (GO:0042554)2.28668034
166startle response (GO:0001964)2.28241244
167positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.27273563
168regulation of ruffle assembly (GO:1900027)2.26092898
169membrane hyperpolarization (GO:0060081)2.23304792
170regulation of neurotransmitter uptake (GO:0051580)2.23143476
171axoneme assembly (GO:0035082)2.22773572
172positive regulation of respiratory burst (GO:0060267)2.22199656
173detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.16930475
174regulation of clathrin-mediated endocytosis (GO:2000369)2.14572771
175sensory perception of chemical stimulus (GO:0007606)2.13569605
176regulation of dopamine metabolic process (GO:0042053)2.12783948
177regulation of catecholamine metabolic process (GO:0042069)2.12783948
178positive regulation of membrane potential (GO:0045838)2.12244349
179detection of chemical stimulus involved in sensory perception (GO:0050907)2.11440045
180positive regulation of ERBB signaling pathway (GO:1901186)2.08167366
181regulation of rhodopsin mediated signaling pathway (GO:0022400)13.6807207
182rhodopsin mediated signaling pathway (GO:0016056)13.3193838
183regulation of water loss via skin (GO:0033561)13.0562091
184retinal cone cell development (GO:0046549)10.5298344
185hair cycle (GO:0042633)10.1821382
186molting cycle (GO:0042303)10.1821382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1P63_26484246_Chip-Seq_KERATINOCYTES_Human4.05694047
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.29518847
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.28410708
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.09855416
5GBX2_23144817_ChIP-Seq_PC3_Human3.01127863
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.00563111
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.77835863
8VDR_22108803_ChIP-Seq_LS180_Human2.51397967
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.26830271
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.23305482
11EZH2_22144423_ChIP-Seq_EOC_Human2.19524901
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.17471136
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.16982749
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10001566
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03916988
16TP63_23658742_ChIP-Seq_EP156T_Human2.03031372
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02770485
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.94575658
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93084669
20IGF1R_20145208_ChIP-Seq_DFB_Human1.92367635
21AR_21572438_ChIP-Seq_LNCaP_Human1.92321751
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89061058
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86885647
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86423971
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.85739378
26HTT_18923047_ChIP-ChIP_STHdh_Human1.83722465
27ERG_20517297_ChIP-Seq_VCAP_Human1.79505784
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.78451292
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.75730412
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.75158179
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74990600
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.74094626
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73936092
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65770145
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65280548
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65280548
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.65196590
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64519196
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61977932
40TP63_22573176_ChIP-Seq_HFKS_Human1.60990881
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58818344
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55331678
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.55023570
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.54758334
45P300_19829295_ChIP-Seq_ESCs_Human1.54428590
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52711589
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50344618
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50328920
49TAF15_26573619_Chip-Seq_HEK293_Human1.49041125
50GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.48402779
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47491287
52RNF2_27304074_Chip-Seq_NSC_Mouse1.47444970
53RXR_22108803_ChIP-Seq_LS180_Human1.47410781
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47204546
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46604967
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46176945
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.44869247
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.43716737
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43597309
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40427169
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37576127
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37209246
63ZNF263_19887448_ChIP-Seq_K562_Human1.36660963
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36193570
65* SMAD4_21799915_ChIP-Seq_A2780_Human1.36189739
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.35287798
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.35285876
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35180727
69DROSHA_22980978_ChIP-Seq_HELA_Human1.34928645
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34490070
71GATA6_21074721_ChIP-Seq_CACO-2_Human1.34412536
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.34328963
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34090507
74LXR_22158963_ChIP-Seq_LIVER_Mouse1.32733939
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.32419242
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32188207
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31329345
78BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.29282588
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.28150436
80TCF4_22108803_ChIP-Seq_LS180_Human1.28145801
81PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27064891
82EGR1_19032775_ChIP-ChIP_M12_Human1.26716626
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.26385150
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.26124738
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.25375979
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25158669
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24933553
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24933553
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23802831
90PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22606653
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21863031
92P53_22387025_ChIP-Seq_ESCs_Mouse1.21758847
93FUS_26573619_Chip-Seq_HEK293_Human1.21508173
94GATA3_24758297_ChIP-Seq_MCF-7_Human1.20891572
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.19571172
96TAF2_19829295_ChIP-Seq_ESCs_Human1.19457312
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18171051
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.17703107
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.17446601
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.16940164
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16543249
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15856426
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.14265376
104RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14042481
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13963791
106NANOG_19829295_ChIP-Seq_ESCs_Human1.13559336
107SOX2_19829295_ChIP-Seq_ESCs_Human1.13559336
108P300_18555785_Chip-Seq_ESCs_Mouse1.13395513
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.12503007
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11948629
111SOX2_18555785_Chip-Seq_ESCs_Mouse1.11265027
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10587397
113ZFX_18555785_Chip-Seq_ESCs_Mouse1.10510026
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.09296102
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.08659149
116KDM2B_26808549_Chip-Seq_REH_Human1.08601932
117PU1_27457419_Chip-Seq_LIVER_Mouse1.07789747
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07600040
119LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06825375
120* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06470476
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05850060
122AR_25329375_ChIP-Seq_VCAP_Human1.05805128
123TBL1_22424771_ChIP-Seq_293T_Human1.05427431
124ESR1_20079471_ChIP-ChIP_T-47D_Human1.05416880
125CTCF_18555785_Chip-Seq_ESCs_Mouse1.05351730
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05297757
127SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05291028
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05139010
129SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05051284
130SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04605284
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04171105
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04096579
133TCF4_18268006_ChIP-ChIP_LS174T_Human1.03922746
134SOX2_20726797_ChIP-Seq_SW620_Human1.03310166
135CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02634900
136ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01893002
137BCAT_22108803_ChIP-Seq_LS180_Human1.01874695
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01706005
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01706005
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01571265
141NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01571265
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01563637
143FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01511461
144GATA4_25053715_ChIP-Seq_YYC3_Human1.01213784
145REST_21632747_ChIP-Seq_MESCs_Mouse1.00770928
146FOXA1_25329375_ChIP-Seq_VCAP_Human1.00698918
147FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00698918
148CRX_20693478_ChIP-Seq_RETINA_Mouse0.99893912
149RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99127448
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.98272628
151FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98238595
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98177928
153TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96880854
154AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94414955
155RBPJ_21746931_ChIP-Seq_IB4_Human0.94403760
156CEBPB_22108803_ChIP-Seq_LS180_Human0.93140384
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.91962949
158CTCF_20526341_ChIP-Seq_ESCs_Human0.91167604
159TP53_18474530_ChIP-ChIP_U2OS_Human0.90739019
160FOXH1_21741376_ChIP-Seq_EPCs_Human0.89051340
161FOXA1_25552417_ChIP-Seq_VCAP_Human0.87430875
162HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87427865
163AR_20517297_ChIP-Seq_VCAP_Human0.86641092
164CTCF_27219007_Chip-Seq_Bcells_Human0.85879156
165HNFA_21074721_ChIP-Seq_CACO-2_Human0.85744164
166RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83799184
167SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83507179
168* P53_21459846_ChIP-Seq_SAOS-2_Human0.83223539
169KLF5_25053715_ChIP-Seq_YYC3_Human0.82009010
170FOXA1_21572438_ChIP-Seq_LNCaP_Human0.81466310
171BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81384630
172CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80508711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog8.16055304
2* MP0003011_delayed_dark_adaptation7.14440709
3MP0005275_abnormal_skin_tensile6.64599446
4* MP0005253_abnormal_eye_physiology5.78167370
5MP0010234_abnormal_vibrissa_follicle5.15233743
6* MP0006072_abnormal_retinal_apoptosis4.99818929
7MP0003950_abnormal_plasma_membrane4.31768867
8MP0009379_abnormal_foot_pigmentation3.91943767
9MP0001986_abnormal_taste_sensitivity3.18134007
10* MP0005195_abnormal_posterior_eye3.09606238
11MP0002638_abnormal_pupillary_reflex2.90225813
12MP0005423_abnormal_somatic_nervous2.83770846
13MP0001324_abnormal_eye_pigmentation2.77852643
14MP0005083_abnormal_biliary_tract2.65572565
15* MP0005391_vision/eye_phenotype2.64281870
16MP0004381_abnormal_hair_follicle2.64109524
17MP0002090_abnormal_vision2.08355208
18MP0005365_abnormal_bile_salt2.04958376
19MP0002796_impaired_skin_barrier1.94540027
20MP0002229_neurodegeneration1.91234435
21MP0005451_abnormal_body_composition1.78911464
22MP0002102_abnormal_ear_morphology1.77783498
23MP0005085_abnormal_gallbladder_physiolo1.73932872
24MP0003880_abnormal_central_pattern1.73135872
25* MP0002752_abnormal_somatic_nervous1.72758158
26MP0003878_abnormal_ear_physiology1.72135553
27MP0005377_hearing/vestibular/ear_phenot1.72135553
28MP0002909_abnormal_adrenal_gland1.62162874
29MP0001188_hyperpigmentation1.62077817
30MP0003191_abnormal_cellular_cholesterol1.59486679
31MP0001984_abnormal_olfaction1.58697488
32MP0006292_abnormal_olfactory_placode1.55280228
33MP0003136_yellow_coat_color1.53787506
34MP0002095_abnormal_skin_pigmentation1.48978385
35MP0010386_abnormal_urinary_bladder1.43070245
36MP0003566_abnormal_cell_adhesion1.42824889
37MP0009931_abnormal_skin_appearance1.36787022
38MP0005409_darkened_coat_color1.35299693
39MP0000579_abnormal_nail_morphology1.34694038
40MP0001764_abnormal_homeostasis1.30801553
41MP0005501_abnormal_skin_physiology1.29489555
42MP0004019_abnormal_vitamin_homeostasis1.28298983
43MP0000383_abnormal_hair_follicle1.28225060
44MP0000367_abnormal_coat/_hair1.26974320
45MP0001486_abnormal_startle_reflex1.21323218
46MP0000647_abnormal_sebaceous_gland1.18772538
47MP0002277_abnormal_respiratory_mucosa1.14480997
48* MP0002882_abnormal_neuron_morphology1.06545593
49MP0004742_abnormal_vestibular_system1.05038743
50MP0003705_abnormal_hypodermis_morpholog1.04455681
51MP0008875_abnormal_xenobiotic_pharmacok1.04211949
52MP0000639_abnormal_adrenal_gland1.03089111
53MP0003941_abnormal_skin_development1.01680017
54MP0005084_abnormal_gallbladder_morpholo1.01658064
55MP0001216_abnormal_epidermal_layer1.01541356
56MP0005174_abnormal_tail_pigmentation1.01360895
57MP0008004_abnormal_stomach_pH0.99972512
58MP0002254_reproductive_system_inflammat0.99931553
59MP0004264_abnormal_extraembryonic_tissu0.98917613
60MP0009672_abnormal_birth_weight0.96797029
61MP0001502_abnormal_circadian_rhythm0.96617849
62MP0000465_gastrointestinal_hemorrhage0.96550064
63MP0010771_integument_phenotype0.95023903
64MP0001243_abnormal_dermal_layer0.94841586
65MP0001346_abnormal_lacrimal_gland0.93729317
66MP0000015_abnormal_ear_pigmentation0.93230895
67MP0003436_decreased_susceptibility_to0.92946144
68MP0002272_abnormal_nervous_system0.92642196
69MP0002098_abnormal_vibrissa_morphology0.90289099
70MP0003122_maternal_imprinting0.89691586
71MP0008260_abnormal_autophagy0.88014204
72MP0000427_abnormal_hair_cycle0.87364675
73MP0002009_preneoplasia0.86658221
74MP0004782_abnormal_surfactant_physiolog0.86256821
75MP0004043_abnormal_pH_regulation0.85337151
76MP0010678_abnormal_skin_adnexa0.84758568
77MP0002060_abnormal_skin_morphology0.83052586
78MP0009780_abnormal_chondrocyte_physiolo0.80034667
79MP0002148_abnormal_hypersensitivity_rea0.78904098
80MP0005499_abnormal_olfactory_system0.78738963
81MP0005394_taste/olfaction_phenotype0.78738963
82MP0001835_abnormal_antigen_presentation0.78634668
83MP0005379_endocrine/exocrine_gland_phen0.78606099
84MP0000026_abnormal_inner_ear0.77677393
85MP0008789_abnormal_olfactory_epithelium0.77305277
86MP0002139_abnormal_hepatobiliary_system0.76642310
87MP0006035_abnormal_mitochondrial_morpho0.76134808
88MP0003453_abnormal_keratinocyte_physiol0.76018990
89MP0008569_lethality_at_weaning0.75199818
90MP0002332_abnormal_exercise_endurance0.74960172
91MP0004885_abnormal_endolymph0.74795514
92MP0005197_abnormal_uvea_morphology0.73739216
93MP0000377_abnormal_hair_follicle0.73582010
94MP0001963_abnormal_hearing_physiology0.72553276
95MP0001851_eye_inflammation0.71695399
96MP0003045_fibrosis0.71672915
97MP0001968_abnormal_touch/_nociception0.71548226
98MP0000762_abnormal_tongue_morphology0.71070753
99MP0001501_abnormal_sleep_pattern0.70024258
100MP0005387_immune_system_phenotype0.68661743
101MP0001790_abnormal_immune_system0.68661743
102MP0009046_muscle_twitch0.68192435
103MP0005075_abnormal_melanosome_morpholog0.64428871
104MP0001905_abnormal_dopamine_level0.64387353
105MP0009745_abnormal_behavioral_response0.64328160
106MP0003315_abnormal_perineum_morphology0.64255670
107MP0001800_abnormal_humoral_immune0.62313083
108MP0004142_abnormal_muscle_tone0.61530956
109MP0002067_abnormal_sensory_capabilities0.60545076
110MP0004947_skin_inflammation0.59449448
111MP0009785_altered_susceptibility_to0.58157682
112MP0000566_synostosis0.57975462
113MP0002064_seizures0.57886636
114MP0009840_abnormal_foam_cell0.57505580
115MP0003183_abnormal_peptide_metabolism0.57479990
116MP0002177_abnormal_outer_ear0.56555471
117MP0010352_gastrointestinal_tract_polyps0.56141450
118MP0002419_abnormal_innate_immunity0.56070132
119MP0002132_abnormal_respiratory_system0.55840830
120MP0005671_abnormal_response_to0.53103949
121MP0002452_abnormal_antigen_presenting0.53058993
122MP0002572_abnormal_emotion/affect_behav0.52120695
123MP0002138_abnormal_hepatobiliary_system0.50657718
124MP0001191_abnormal_skin_condition0.50204809
125MP0005000_abnormal_immune_tolerance0.50178261
126MP0002735_abnormal_chemical_nociception0.49760640
127MP0005310_abnormal_salivary_gland0.49324607
128MP0002127_abnormal_cardiovascular_syste0.48860965
129MP0002723_abnormal_immune_serum0.48527599
130MP0003634_abnormal_glial_cell0.47669831
131MP0005025_abnormal_response_to0.47307158
132MP0002734_abnormal_mechanical_nocicepti0.46659875
133MP0000467_abnormal_esophagus_morphology0.46205344
134MP0010368_abnormal_lymphatic_system0.45725102
135MP0001765_abnormal_ion_homeostasis0.45338649
136MP0005187_abnormal_penis_morphology0.45136871
137MP0009764_decreased_sensitivity_to0.44244429
138MP0003635_abnormal_synaptic_transmissio0.44182541
139MP0003868_abnormal_feces_composition0.42237828
140MP0001340_abnormal_eyelid_morphology0.42057530
141MP0001440_abnormal_grooming_behavior0.41899949
142MP0005636_abnormal_mineral_homeostasis0.38572680
143MP0010329_abnormal_lipoprotein_level0.37409952
144MP0001186_pigmentation_phenotype0.36607385
145MP0002118_abnormal_lipid_homeostasis0.35048876
146MP0001784_abnormal_fluid_regulation0.34938572
147MP0001661_extended_life_span0.34596672
148MP0001756_abnormal_urination0.34277040
149MP0000372_irregular_coat_pigmentation0.32585454
150MP0005023_abnormal_wound_healing0.31893935
151MP0001485_abnormal_pinna_reflex0.31747146
152MP0005647_abnormal_sex_gland0.30676123
153MP0005332_abnormal_amino_acid0.30320342
154MP0003195_calcinosis0.29072109
155MP0008995_early_reproductive_senescence0.25918750
156MP0003638_abnormal_response/metabolism_0.24350001
157MP0005408_hypopigmentation0.21589655

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)9.94553623
2Absent rod-and cone-mediated responses on ERG (HP:0007688)9.22711215
3Abnormal rod and cone electroretinograms (HP:0008323)9.18121813
4Palmar hyperkeratosis (HP:0010765)7.82863524
5Pigmentary retinal degeneration (HP:0001146)7.63093391
6Attenuation of retinal blood vessels (HP:0007843)7.57494111
7Chorioretinal atrophy (HP:0000533)7.26238088
8Pendular nystagmus (HP:0012043)6.24393247
9Abnormality of macular pigmentation (HP:0008002)6.19026553
10Central scotoma (HP:0000603)6.14844102
11Decreased central vision (HP:0007663)6.01991128
12Dyschromatopsia (HP:0007641)5.84763126
13Oral leukoplakia (HP:0002745)5.80013463
14Scotoma (HP:0000575)5.49543955
15Abolished electroretinogram (ERG) (HP:0000550)5.40416096
16Alopecia of scalp (HP:0002293)5.39693563
17Thick nail (HP:0001805)5.14755441
18* Photophobia (HP:0000613)5.01162142
19Corneal erosion (HP:0200020)4.98480588
20Conjunctival hamartoma (HP:0100780)4.94801866
21Keratoconus (HP:0000563)4.78014715
22Increased corneal curvature (HP:0100692)4.78014715
23Absent eyelashes (HP:0000561)4.59242841
24* Type II diabetes mellitus (HP:0005978)4.56007259
25Woolly hair (HP:0002224)4.50807573
26Retinitis pigmentosa (HP:0000510)4.15923162
27Macular degeneration (HP:0000608)4.14642475
28Palmoplantar keratoderma (HP:0000982)4.03351809
29Cone-rod dystrophy (HP:0000548)3.97618271
30Absent hair (HP:0002298)3.90964323
31Severe visual impairment (HP:0001141)3.90182749
32Gangrene (HP:0100758)3.82987709
33Sparse eyelashes (HP:0000653)3.66171685
34Fragile nails (HP:0001808)3.64255819
35Vitreoretinal degeneration (HP:0000655)3.63558816
36Choroideremia (HP:0001139)3.59029569
37Pili torti (HP:0003777)3.44975676
38Nail dystrophy (HP:0008404)3.43250627
39Constricted visual fields (HP:0001133)3.30924728
40Congenital sensorineural hearing impairment (HP:0008527)3.23824436
41Right ventricular cardiomyopathy (HP:0011663)3.22930319
42Hamartoma of the eye (HP:0010568)3.18129924
43Abnormality of the salivary glands (HP:0010286)3.04157419
44Abnormal blistering of the skin (HP:0008066)3.00490955
45Abnormal hair laboratory examination (HP:0003328)2.96454009
46Renal salt wasting (HP:0000127)2.88304539
47Brittle hair (HP:0002299)2.77476040
48Eczematoid dermatitis (HP:0000976)2.77322237
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.76873090
50Pruritus (HP:0000989)2.68229573
51Progressive visual loss (HP:0000529)2.66511671
52Sparse scalp hair (HP:0002209)2.62066223
53Lack of skin elasticity (HP:0100679)2.49264276
54Furrowed tongue (HP:0000221)2.44771554
55Optic disc pallor (HP:0000543)2.43553133
56Gait imbalance (HP:0002141)2.42301467
57Congenital primary aphakia (HP:0007707)2.40242943
58Abnormality of hair growth rate (HP:0011363)2.37502990
59Slow-growing hair (HP:0002217)2.37502990
60Posterior subcapsular cataract (HP:0007787)2.36128330
61Parakeratosis (HP:0001036)2.34738860
62Dry hair (HP:0011359)2.33809425
63Follicular hyperkeratosis (HP:0007502)2.32855868
64Medial flaring of the eyebrow (HP:0010747)2.30007572
65Nephrogenic diabetes insipidus (HP:0009806)2.22576840
66Blepharitis (HP:0000498)2.16101192
67Absent eyebrow (HP:0002223)2.12371999
68* Wide nasal bridge (HP:0000431)2.02736172
69Amniotic constriction ring (HP:0009775)2.00380624
70Abnormality of placental membranes (HP:0011409)2.00380624
71Congenital stationary night blindness (HP:0007642)14.5463164
72Bony spicule pigmentary retinopathy (HP:0007737)10.5460875
73Abnormality of the lacrimal duct (HP:0011481)1.94481928
74Lip pit (HP:0100267)1.91733937
75Septo-optic dysplasia (HP:0100842)1.91549591
76Pustule (HP:0200039)1.91286371
77Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.89127530
78Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87140995
79Hypoplastic labia majora (HP:0000059)1.86556061
80Vaginal atresia (HP:0000148)1.84921259
81True hermaphroditism (HP:0010459)1.83975845
82Hyperhidrosis (HP:0000975)1.82842242
83Dehydration (HP:0001944)1.82125820
84Ridged nail (HP:0001807)1.80603338
85Dysdiadochokinesis (HP:0002075)1.80256676
86Genital tract atresia (HP:0001827)1.79767532
87Hypergammaglobulinemia (HP:0010702)1.79736157
88Recurrent sinusitis (HP:0011108)1.78819129
89Azoospermia (HP:0000027)1.77989878
90Melanocytic nevus (HP:0000995)1.77726785
91Taurodontia (HP:0000679)1.76799849
92Abnormality of permanent molar morphology (HP:0011071)1.76799849
93Abnormality of the dental root (HP:0006486)1.76799849
94Febrile seizures (HP:0002373)1.75681524
95Selective tooth agenesis (HP:0001592)1.74622083
96Poor coordination (HP:0002370)1.73258690
97Aplasia/Hypoplasia of the lens (HP:0008063)1.71859525
98Advanced eruption of teeth (HP:0006288)1.71289057
99Autoamputation (HP:0001218)1.70782672
100Dry skin (HP:0000958)1.68153405
101Labial hypoplasia (HP:0000066)1.67673991
102Hypotrichosis (HP:0001006)1.66725854
103Premature ovarian failure (HP:0008209)1.65307539
104Abnormality of the labia majora (HP:0012881)1.64780037
105Retinal atrophy (HP:0001105)1.64631975
106Septate vagina (HP:0001153)1.64323990
107Abnormality of the nasolacrimal system (HP:0000614)1.63649040
108Abnormality of molar morphology (HP:0011070)1.62357580
109Abnormality of molar (HP:0011077)1.62357580
110Increased IgE level (HP:0003212)1.62049434
111Interstitial pulmonary disease (HP:0006530)1.61429093
112Erythema (HP:0010783)1.59968574
113Hyperaldosteronism (HP:0000859)1.58989688
114Fine hair (HP:0002213)1.58833614
115Action tremor (HP:0002345)1.57501120
116Urticaria (HP:0001025)1.57451109
117Myokymia (HP:0002411)1.57016010
118Abnormality of the dental pulp (HP:0006479)1.56066880
119Chromsome breakage (HP:0040012)1.55655371
120Hypoplastic female external genitalia (HP:0012815)1.55155024
121Milia (HP:0001056)1.54625467
122Natal tooth (HP:0000695)1.54111495
123Laryngomalacia (HP:0001601)1.53868389
124Recurrent corneal erosions (HP:0000495)1.53015919
125Nasolacrimal duct obstruction (HP:0000579)1.51410566
126Hamartoma (HP:0010566)1.49831826
127Astigmatism (HP:0000483)1.47082761
128Severe Myopia (HP:0011003)1.46923044
129Intention tremor (HP:0002080)1.46763769
130Conical tooth (HP:0000698)1.46104806
131Epidermoid cyst (HP:0200040)1.45686136
132Aplasia involving bones of the upper limbs (HP:0009823)1.44733075
133Aplasia of the phalanges of the hand (HP:0009802)1.44733075
134Aplasia involving bones of the extremities (HP:0009825)1.44733075
135Corneal dystrophy (HP:0001131)1.44240865
136Congenital ichthyosiform erythroderma (HP:0007431)1.43184279
137Multifactorial inheritance (HP:0001426)1.42861148
138Retrobulbar optic neuritis (HP:0100654)1.42697419
139Optic neuritis (HP:0100653)1.42697419
140Abnormality of dental color (HP:0011073)1.42381453
141Subcapsular cataract (HP:0000523)1.41373457
142Asthma (HP:0002099)1.40623782
143Hypoplasia of the fovea (HP:0007750)1.38776679
144Aplasia/Hypoplasia of the fovea (HP:0008060)1.38776679
145Ectropion (HP:0000656)1.38366303
146Abnormality of the axillary hair (HP:0100134)1.38310292
147Abnormality of secondary sexual hair (HP:0009888)1.38310292
148Xerostomia (HP:0000217)1.37574866
149Acanthosis nigricans (HP:0000956)1.36558545
150Upper limb muscle weakness (HP:0003484)1.34846922
151Pancreatic fibrosis (HP:0100732)1.34316761
152Prostate neoplasm (HP:0100787)1.33892432
153* Optic atrophy (HP:0000648)1.31682637
154Plantar hyperkeratosis (HP:0007556)1.31342477
155Duplicated collecting system (HP:0000081)1.30793164
156Progressive cerebellar ataxia (HP:0002073)1.29942515
157Hypodontia (HP:0000668)1.29439210
158Chronic obstructive pulmonary disease (HP:0006510)1.25014158
159Obstructive lung disease (HP:0006536)1.25014158
160Chorioretinal coloboma (HP:0000567)1.24364383
161Abnormality of the fovea (HP:0000493)1.23576949
162Stomatitis (HP:0010280)1.21524886
163Absent septum pellucidum (HP:0001331)1.20690146
164Amelogenesis imperfecta (HP:0000705)1.20379689
165Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.19761298
166Abnormality of the renal collecting system (HP:0004742)1.19713927
167Focal motor seizures (HP:0011153)1.17574629
168Onycholysis (HP:0001806)1.17195441
169Agammaglobulinemia (HP:0004432)1.16211349
170Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.15338588
171Erythroderma (HP:0001019)1.15034965
172Recurrent abscess formation (HP:0002722)1.14067656
173Pancreatic cysts (HP:0001737)1.13473867
174Epileptic encephalopathy (HP:0200134)1.12839319
175Palmoplantar hyperkeratosis (HP:0000972)1.12315754
176Abnormal sex determination (HP:0012244)1.12256864
177Sex reversal (HP:0012245)1.12256864
178Hypohidrosis (HP:0000966)1.10183828
179Absent/shortened dynein arms (HP:0200106)1.08828637
180Dynein arm defect of respiratory motile cilia (HP:0012255)1.08828637
181Male pseudohermaphroditism (HP:0000037)1.08446639
182Meningitis (HP:0001287)1.07893242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK17.47112102
2NME16.38913862
3PBK5.03569353
4TGFBR13.82713407
5STK243.39555348
6CASK3.39144956
7MAP3K92.98229065
8EIF2AK12.56643343
9MAPKAPK32.54993888
10FGFR12.54587971
11BLK2.45095619
12EPHA22.41602674
13EIF2AK32.24294345
14TNIK2.19487028
15IRAK22.09865559
16CAMK1D1.90662645
17FGFR31.82940917
18EEF2K1.78704591
19INSRR1.74286788
20TAOK31.70143921
21TNK21.64696503
22WNK31.61758949
23MYLK1.53814869
24AKT31.51861494
25RIPK41.49827289
26CDK31.48587498
27FES1.48406240
28IRAK41.42430399
29EPHA31.38873130
30GRK71.37810264
31PRKD31.30932349
32EPHA41.29696703
33BMPR1B1.26631960
34CLK11.23867109
35MAP3K141.23480349
36BMPR21.23251980
37EIF2AK21.21208920
38TTK1.21055820
39TSSK61.20261383
40ADRBK11.18610332
41PIK3CG1.18568936
42MUSK1.17531825
43FGFR41.17089081
44ERBB31.13953977
45MAP3K21.11184161
46ADRBK21.11116026
47PINK11.10140226
48IRAK11.06597791
49TEC1.04929589
50TXK1.04591435
51MKNK21.04472350
52BRD41.03897135
53NEK61.03817699
54TESK11.03633255
55FGR1.00997801
56MAPK71.00518764
57YES10.99788520
58PKN10.98449891
59STK160.97771016
60ABL20.97583832
61MAPKAPK50.97495582
62MAP3K130.96637216
63FRK0.95429272
64BTK0.95120263
65TRPM70.94936159
66EPHB20.93737640
67PIM20.90954285
68CCNB10.89966254
69MAPK120.85591468
70SIK20.85174041
71ACVR1B0.84428930
72EPHB10.84415873
73ARAF0.84297400
74MST40.80636601
75MST1R0.76634079
76RPS6KB10.74837954
77STK30.74820631
78DYRK1A0.74398976
79MAP2K70.73582385
80PDK20.72576383
81MAPK130.71775768
82PRKCG0.70915481
83MAP2K60.70909410
84CAMK1G0.70323018
85STK38L0.68935465
86CSNK1G20.67862241
87MAP3K120.66867901
88MAP4K10.65517272
89HIPK20.64600418
90PRKCE0.64416226
91LATS10.64071503
92STK110.63866141
93STK390.63822483
94PRPF4B0.63663975
95SGK20.62902714
96BRAF0.62287129
97CSK0.61151527
98IKBKE0.61069538
99SYK0.60091082
100HCK0.59775227
101FER0.59548309
102CSNK1G10.59536213
103CAMK2A0.59227260
104DYRK30.59124757
105LYN0.58329055
106PAK40.58179565
107MARK20.57645021
108MAP2K40.57626581
109BCR0.56876269
110MAP3K30.56599406
111RPS6KA50.55896709
112CAMKK20.55469868
113SGK30.55412020
114MAP3K60.55319059
115ITK0.55178025
116FGFR20.55049640
117IRAK30.54294569
118CAMK10.54289411
119SGK2230.51989784
120SGK4940.51989784
121NME20.51969799
122IKBKB0.51948930
123PRKCZ0.51745270
124MAP3K50.51688624
125GRK50.51181107
126MET0.50822062
127CSNK1G30.50182523
128LATS20.49885954
129NLK0.49719375
130CSNK1D0.48923489
131NTRK20.48393628
132PRKD20.48011704
133PRKCQ0.47498259
134TGFBR20.46669283
135NTRK30.46634913
136CSNK1A1L0.45276867
137CSNK1E0.44327569
138PRKCB0.44234795
139NUAK10.44055231
140TIE10.43917973
141OXSR10.43607970
142SGK10.43183319
143MOS0.43130050
144PRKAA20.43097606
145LCK0.42214714
146FYN0.42191890
147ZAK0.41201826
148PNCK0.39562652
149PRKACA0.38889887
150WNK10.38836424
151JAK10.38465579
152PRKG10.36522913
153TAOK20.36288950
154RPS6KB20.35549929
155CAMK2D0.34982912
156DYRK20.34964175
157GSK3A0.34876476
158CDK90.34461871
159MAPKAPK20.34306633
160RPS6KA40.34041483
161MKNK10.33205836
162CDK60.30788751
163CDK70.29786488
164PTK20.29311989
165RIPK10.28386223
166MINK10.27481470
167AKT20.26271846
168DAPK10.26238695
169MAP3K10.23901578
170TAF10.23113446

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid hormone biosynthesis_Homo sapiens_hsa001402.57464212
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.26944432
3Steroid biosynthesis_Homo sapiens_hsa001002.19934190
4Phototransduction_Homo sapiens_hsa0474413.6100307
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.97904041
6beta-Alanine metabolism_Homo sapiens_hsa004101.79484833
7Nitrogen metabolism_Homo sapiens_hsa009101.69985893
8Fat digestion and absorption_Homo sapiens_hsa049751.57785884
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55968286
10Olfactory transduction_Homo sapiens_hsa047401.52864094
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47979808
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47675028
13Nicotine addiction_Homo sapiens_hsa050331.41638487
14Chemical carcinogenesis_Homo sapiens_hsa052041.36953520
15Sphingolipid metabolism_Homo sapiens_hsa006001.36267384
16Fatty acid degradation_Homo sapiens_hsa000711.32140457
17Serotonergic synapse_Homo sapiens_hsa047261.30493212
18Synaptic vesicle cycle_Homo sapiens_hsa047211.29890226
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27054073
20Pyruvate metabolism_Homo sapiens_hsa006201.25055926
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24928884
22Complement and coagulation cascades_Homo sapiens_hsa046101.22001435
23Morphine addiction_Homo sapiens_hsa050321.21013082
24Tryptophan metabolism_Homo sapiens_hsa003801.19149161
25Oxidative phosphorylation_Homo sapiens_hsa001901.17819994
26GABAergic synapse_Homo sapiens_hsa047271.15856041
27Glutamatergic synapse_Homo sapiens_hsa047241.14841698
28PPAR signaling pathway_Homo sapiens_hsa033201.10274621
29Ether lipid metabolism_Homo sapiens_hsa005651.08415570
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07705381
31Arginine biosynthesis_Homo sapiens_hsa002201.04669869
32Phenylalanine metabolism_Homo sapiens_hsa003601.04513309
33Vitamin B6 metabolism_Homo sapiens_hsa007501.03273008
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00167849
35Linoleic acid metabolism_Homo sapiens_hsa005910.97929155
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97248791
37Tyrosine metabolism_Homo sapiens_hsa003500.97168121
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96021421
39Bile secretion_Homo sapiens_hsa049760.93411260
40Cholinergic synapse_Homo sapiens_hsa047250.93269772
41Alzheimers disease_Homo sapiens_hsa050100.91650814
42Circadian entrainment_Homo sapiens_hsa047130.90694716
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89351131
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86994032
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86937245
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83144831
47Arginine and proline metabolism_Homo sapiens_hsa003300.81293787
48Circadian rhythm_Homo sapiens_hsa047100.78768938
49Glycerolipid metabolism_Homo sapiens_hsa005610.77746813
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77277773
51Dopaminergic synapse_Homo sapiens_hsa047280.75625103
52Primary immunodeficiency_Homo sapiens_hsa053400.75599941
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75008987
54Arachidonic acid metabolism_Homo sapiens_hsa005900.74637719
55Parkinsons disease_Homo sapiens_hsa050120.71824994
56Fatty acid metabolism_Homo sapiens_hsa012120.71734492
57Selenocompound metabolism_Homo sapiens_hsa004500.70764524
58ABC transporters_Homo sapiens_hsa020100.69646619
59Rheumatoid arthritis_Homo sapiens_hsa053230.67499243
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67245185
61Fatty acid elongation_Homo sapiens_hsa000620.67031877
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66597497
63* Retinol metabolism_Homo sapiens_hsa008300.65520997
64Hematopoietic cell lineage_Homo sapiens_hsa046400.64483670
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64256262
66Autoimmune thyroid disease_Homo sapiens_hsa053200.64217439
67Salivary secretion_Homo sapiens_hsa049700.63594251
68Taste transduction_Homo sapiens_hsa047420.63369161
69Chemokine signaling pathway_Homo sapiens_hsa040620.63067915
70Renin secretion_Homo sapiens_hsa049240.62943999
71Asthma_Homo sapiens_hsa053100.61624108
72Fatty acid biosynthesis_Homo sapiens_hsa000610.61387288
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61324895
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61004017
75Collecting duct acid secretion_Homo sapiens_hsa049660.60459321
76Glutathione metabolism_Homo sapiens_hsa004800.59004084
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.58562724
78Butanoate metabolism_Homo sapiens_hsa006500.58246598
79Oxytocin signaling pathway_Homo sapiens_hsa049210.57939134
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.57710621
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56754615
82Renin-angiotensin system_Homo sapiens_hsa046140.56614600
83VEGF signaling pathway_Homo sapiens_hsa043700.56425226
84Calcium signaling pathway_Homo sapiens_hsa040200.56276843
85Ras signaling pathway_Homo sapiens_hsa040140.54421421
86Graft-versus-host disease_Homo sapiens_hsa053320.53699745
87* Metabolic pathways_Homo sapiens_hsa011000.50670159
88cAMP signaling pathway_Homo sapiens_hsa040240.50577375
89Allograft rejection_Homo sapiens_hsa053300.49076330
90Inositol phosphate metabolism_Homo sapiens_hsa005620.48969063
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48682569
92Ovarian steroidogenesis_Homo sapiens_hsa049130.46839003
93Axon guidance_Homo sapiens_hsa043600.46680591
94Fanconi anemia pathway_Homo sapiens_hsa034600.46097949
95Osteoclast differentiation_Homo sapiens_hsa043800.46028260
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44870212
97Leishmaniasis_Homo sapiens_hsa051400.44416407
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44401854
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43971442
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.43530891
101Sulfur metabolism_Homo sapiens_hsa009200.43307958
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43161542
103Lysosome_Homo sapiens_hsa041420.42418032
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42282118
105Long-term depression_Homo sapiens_hsa047300.42260774
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41799168
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41125547
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40605189
109Huntingtons disease_Homo sapiens_hsa050160.40529145
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.40164057
111Peroxisome_Homo sapiens_hsa041460.39701948
112Long-term potentiation_Homo sapiens_hsa047200.39508878
113Regulation of autophagy_Homo sapiens_hsa041400.39080412
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.38994526
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38941482
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38894153
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38821504
118Malaria_Homo sapiens_hsa051440.37819075
119Propanoate metabolism_Homo sapiens_hsa006400.36819664
120Insulin secretion_Homo sapiens_hsa049110.36601554
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.36394919
122Amoebiasis_Homo sapiens_hsa051460.36386577
123GnRH signaling pathway_Homo sapiens_hsa049120.35906924
124MAPK signaling pathway_Homo sapiens_hsa040100.35162910
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34570763
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34494005
127Cocaine addiction_Homo sapiens_hsa050300.34052620
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33517118
129Pancreatic secretion_Homo sapiens_hsa049720.33464742
130Mineral absorption_Homo sapiens_hsa049780.32887740
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.32619758
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32405955
133Gastric acid secretion_Homo sapiens_hsa049710.31969743
134B cell receptor signaling pathway_Homo sapiens_hsa046620.31585904
135Tuberculosis_Homo sapiens_hsa051520.30969523
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30759243
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.30683721
138Carbon metabolism_Homo sapiens_hsa012000.30139402
139Vitamin digestion and absorption_Homo sapiens_hsa049770.29214287
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28314185
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27681732
142Choline metabolism in cancer_Homo sapiens_hsa052310.27261841
143Amphetamine addiction_Homo sapiens_hsa050310.27201644
144African trypanosomiasis_Homo sapiens_hsa051430.26833788
145Histidine metabolism_Homo sapiens_hsa003400.25598436
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.25563518
147Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25454606
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25386642
149Phagosome_Homo sapiens_hsa041450.24604416
150Measles_Homo sapiens_hsa051620.24105321
151Purine metabolism_Homo sapiens_hsa002300.23894627
152Dorso-ventral axis formation_Homo sapiens_hsa043200.23704627
153Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23589950
154T cell receptor signaling pathway_Homo sapiens_hsa046600.21980083
155Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21265603
156Alcoholism_Homo sapiens_hsa050340.20749600
157TNF signaling pathway_Homo sapiens_hsa046680.20645479
158Staphylococcus aureus infection_Homo sapiens_hsa051500.20637293
159Wnt signaling pathway_Homo sapiens_hsa043100.19556073

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