RDH13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.84897678
2cullin deneddylation (GO:0010388)4.82567202
3fucose catabolic process (GO:0019317)4.65181193
4L-fucose metabolic process (GO:0042354)4.65181193
5L-fucose catabolic process (GO:0042355)4.65181193
6heart contraction (GO:0060047)4.51665607
7heart process (GO:0003015)4.51665607
8protein deneddylation (GO:0000338)4.49519673
9viral mRNA export from host cell nucleus (GO:0046784)4.48835655
10purine nucleobase biosynthetic process (GO:0009113)4.48149546
11oxidative phosphorylation (GO:0006119)4.16515068
12DNA deamination (GO:0045006)4.05301187
13positive regulation of mitochondrial fission (GO:0090141)3.97674134
14actin-myosin filament sliding (GO:0033275)3.90605562
15muscle filament sliding (GO:0030049)3.90605562
16nucleobase biosynthetic process (GO:0046112)3.81131947
17cellular ketone body metabolic process (GO:0046950)3.78776038
18cytochrome complex assembly (GO:0017004)3.76273249
19protein complex biogenesis (GO:0070271)3.74710094
20kynurenine metabolic process (GO:0070189)3.66115219
21polyketide metabolic process (GO:0030638)3.60982408
22doxorubicin metabolic process (GO:0044598)3.60982408
23daunorubicin metabolic process (GO:0044597)3.60982408
24actin-mediated cell contraction (GO:0070252)3.54820907
25negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.52201521
26kidney morphogenesis (GO:0060993)3.47084600
27negative regulation of dendrite morphogenesis (GO:0050774)3.46457033
28platelet dense granule organization (GO:0060155)3.45557877
29protein-cofactor linkage (GO:0018065)3.44763527
30tryptophan catabolic process (GO:0006569)3.44634388
31indole-containing compound catabolic process (GO:0042436)3.44634388
32indolalkylamine catabolic process (GO:0046218)3.44634388
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41857734
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.41857734
35NADH dehydrogenase complex assembly (GO:0010257)3.41857734
36respiratory chain complex IV assembly (GO:0008535)3.40029263
37ketone body metabolic process (GO:1902224)3.39552242
38mitochondrial respiratory chain complex assembly (GO:0033108)3.35707011
39preassembly of GPI anchor in ER membrane (GO:0016254)3.34511727
40piRNA metabolic process (GO:0034587)3.33578461
41inositol phosphate catabolic process (GO:0071545)3.28319298
42detection of light stimulus involved in visual perception (GO:0050908)3.28031727
43detection of light stimulus involved in sensory perception (GO:0050962)3.28031727
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.26443222
45indolalkylamine metabolic process (GO:0006586)3.24965964
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.23849477
47negative regulation of telomere maintenance (GO:0032205)3.21606260
48IMP biosynthetic process (GO:0006188)3.21549549
49fucosylation (GO:0036065)3.19237056
50reciprocal meiotic recombination (GO:0007131)3.18782038
51reciprocal DNA recombination (GO:0035825)3.18782038
52response to pheromone (GO:0019236)3.17513045
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.17294129
54poly(A)+ mRNA export from nucleus (GO:0016973)3.17015021
55DNA methylation involved in gamete generation (GO:0043046)3.16952174
56negative regulation of striated muscle cell apoptotic process (GO:0010664)3.14633730
57regulation of relaxation of muscle (GO:1901077)3.13737710
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13620296
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13620296
60water-soluble vitamin biosynthetic process (GO:0042364)3.12861057
61cardiac myofibril assembly (GO:0055003)3.10649185
62intraciliary transport (GO:0042073)3.10343681
63tricarboxylic acid cycle (GO:0006099)3.09768326
64phosphatidylinositol acyl-chain remodeling (GO:0036149)3.08852420
65tryptophan metabolic process (GO:0006568)3.06609174
66regulation of hippo signaling (GO:0035330)3.06030709
67regulation of mitochondrial translation (GO:0070129)3.05650699
68DNA double-strand break processing (GO:0000729)3.05201746
69cardiac muscle hypertrophy (GO:0003300)3.04320046
70GMP metabolic process (GO:0046037)3.02548314
712-deoxyribonucleotide biosynthetic process (GO:0009265)3.02221357
72deoxyribose phosphate biosynthetic process (GO:0046385)3.02221357
73phosphatidylserine acyl-chain remodeling (GO:0036150)2.99213777
74cornea development in camera-type eye (GO:0061303)2.97480467
75tRNA modification (GO:0006400)2.96905346
76cardiac muscle tissue morphogenesis (GO:0055008)2.94234586
77proteasome assembly (GO:0043248)2.93237718
78regulation of G0 to G1 transition (GO:0070316)2.92643209
79protein K11-linked deubiquitination (GO:0035871)2.91918264
80protein neddylation (GO:0045116)2.89614008
81myofibril assembly (GO:0030239)2.88596641
82protein import into peroxisome matrix (GO:0016558)2.87813048
83striated muscle hypertrophy (GO:0014897)2.85965129
84pseudouridine synthesis (GO:0001522)2.83666828
85DNA replication checkpoint (GO:0000076)2.83039671
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.82250979
87positive regulation of fatty acid transport (GO:2000193)2.80644068
88somite development (GO:0061053)2.77164945
89cardiac muscle contraction (GO:0060048)2.75434559
90recombinational repair (GO:0000725)2.75365140
91regulation of glucokinase activity (GO:0033131)2.75017935
92regulation of hexokinase activity (GO:1903299)2.75017935
93phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.74963668
94double-strand break repair via homologous recombination (GO:0000724)2.74640227
95mannosylation (GO:0097502)2.74515883
96neuronal action potential (GO:0019228)2.72526699
97positive regulation of prostaglandin secretion (GO:0032308)2.71234457
98cellular response to ATP (GO:0071318)2.70959588
99deoxyribonucleotide biosynthetic process (GO:0009263)2.70271280
100negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.69800111
101rRNA catabolic process (GO:0016075)2.69543243
102GPI anchor metabolic process (GO:0006505)2.69445416
103ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.67854831
104muscle hypertrophy (GO:0014896)2.67656161
105auditory receptor cell stereocilium organization (GO:0060088)2.65210512
106regulation of action potential (GO:0098900)2.64226564
107rRNA methylation (GO:0031167)2.64065499
108estrogen biosynthetic process (GO:0006703)2.63555938
109regulation of myoblast differentiation (GO:0045661)2.62833991
110rRNA modification (GO:0000154)2.62305364
111aerobic respiration (GO:0009060)2.62056187
112muscle tissue morphogenesis (GO:0060415)2.61928986
113L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60417485
114regulation of mitochondrial fission (GO:0090140)2.60276326
115spinal cord motor neuron differentiation (GO:0021522)2.59789464
116negative regulation of stem cell proliferation (GO:2000647)2.59747767
117negative regulation of reactive oxygen species metabolic process (GO:2000378)2.59020272
118nephron tubule morphogenesis (GO:0072078)2.58624015
119nephron epithelium morphogenesis (GO:0072088)2.58624015
120energy coupled proton transport, down electrochemical gradient (GO:0015985)2.58454365
121ATP synthesis coupled proton transport (GO:0015986)2.58454365
122negative regulation of translation, ncRNA-mediated (GO:0040033)2.58014057
123regulation of translation, ncRNA-mediated (GO:0045974)2.58014057
124negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.58014057
125DNA demethylation (GO:0080111)2.57949638
126neural tube formation (GO:0001841)2.57877476
127sulfation (GO:0051923)2.57696648
128meiotic chromosome segregation (GO:0045132)2.57122368
129tRNA methylation (GO:0030488)2.56973839
130chaperone-mediated protein transport (GO:0072321)2.56816701
131signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.56109100
132signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.56109100
133signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.56109100
134viral protein processing (GO:0019082)2.55885102
135ubiquinone metabolic process (GO:0006743)2.55602138
136DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.55416031
137startle response (GO:0001964)2.54265400
138tRNA processing (GO:0008033)2.53665808
139purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.53631944
1403-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.53631944
141generation of neurons (GO:0048699)2.53548935
142quinone biosynthetic process (GO:1901663)2.53322864
143ubiquinone biosynthetic process (GO:0006744)2.53322864
144aggressive behavior (GO:0002118)2.53172150
145NADH metabolic process (GO:0006734)2.52659292
146male meiosis I (GO:0007141)2.52441541
147S-adenosylmethionine metabolic process (GO:0046500)2.51258556
148positive regulation of cardiac muscle tissue development (GO:0055025)2.51196338
149signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.50925255
150intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.50925255
151axoneme assembly (GO:0035082)2.49904974
152indole-containing compound metabolic process (GO:0042430)2.48459252
153cilium or flagellum-dependent cell motility (GO:0001539)2.48063622
154inositol phosphate dephosphorylation (GO:0046855)2.47921030
155phosphorylated carbohydrate dephosphorylation (GO:0046838)2.47921030
156synaptic transmission, cholinergic (GO:0007271)2.47659227
157histone arginine methylation (GO:0034969)2.46855550
158regulation of skeletal muscle fiber development (GO:0048742)2.46312364
159positive regulation of cardiac muscle cell proliferation (GO:0060045)2.45464794
1607-methylguanosine mRNA capping (GO:0006370)2.44984041
161histamine secretion (GO:0001821)2.44760787
162regulation of mitotic spindle checkpoint (GO:1903504)2.44617157
163regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.44617157
164protein K6-linked ubiquitination (GO:0085020)2.43876984
165signal transduction involved in cell cycle checkpoint (GO:0072395)2.43244787
166sarcomere organization (GO:0045214)2.43143031
167DNA damage response, detection of DNA damage (GO:0042769)2.42763299
168replication fork processing (GO:0031297)2.42607275
169positive regulation of icosanoid secretion (GO:0032305)2.42517878
170IMP metabolic process (GO:0046040)2.42494959
171atrial cardiac muscle cell action potential (GO:0086014)2.42217669
172cell differentiation involved in metanephros development (GO:0072202)2.42155966
173mitochondrial RNA metabolic process (GO:0000959)2.41640326
174NAD biosynthetic process (GO:0009435)2.41247602
175primary amino compound metabolic process (GO:1901160)2.41097564
1767-methylguanosine RNA capping (GO:0009452)2.40956132
177RNA capping (GO:0036260)2.40956132
178keratinization (GO:0031424)2.40937382
179multicellular organism reproduction (GO:0032504)2.40021922
180transepithelial transport (GO:0070633)2.39356903
181centriole replication (GO:0007099)2.37224111
182reflex (GO:0060004)2.37134625
183negative regulation of T cell differentiation in thymus (GO:0033085)2.36920634
184epithelial cilium movement (GO:0003351)2.36666564
185amine catabolic process (GO:0009310)2.36531040

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.59396267
2E2F7_22180533_ChIP-Seq_HELA_Human4.53318794
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.25573122
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.39413878
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00279958
6SRF_21415370_ChIP-Seq_HL-1_Mouse2.87805952
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81714114
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.78123496
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.74421703
10GBX2_23144817_ChIP-Seq_PC3_Human2.73566989
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64829012
12YY1_21170310_ChIP-Seq_MESCs_Mouse2.56754533
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52954682
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48993240
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43900955
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42479104
17YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.41274140
18* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.40160985
19ELK1_19687146_ChIP-ChIP_HELA_Human2.37129304
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26995328
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.26172881
22EZH2_22144423_ChIP-Seq_EOC_Human2.25027430
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24450789
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19558130
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16393986
26TP63_19390658_ChIP-ChIP_HaCaT_Human2.16333206
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15760451
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09937162
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.08582328
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.04798449
31* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01157723
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94264910
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90460836
34TP53_22573176_ChIP-Seq_HFKS_Human1.89326351
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86374821
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80274171
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77134694
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.73544692
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69156166
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67797264
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67058607
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66624428
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64960404
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64488077
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63689263
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63266641
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62479409
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61915494
49VDR_23849224_ChIP-Seq_CD4+_Human1.61884959
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60079063
51HOXB7_26014856_ChIP-Seq_BT474_Human1.57257050
52IRF1_19129219_ChIP-ChIP_H3396_Human1.53967727
53ERA_21632823_ChIP-Seq_H3396_Human1.53223572
54EWS_26573619_Chip-Seq_HEK293_Human1.51011253
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.50407212
56FUS_26573619_Chip-Seq_HEK293_Human1.49729723
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.47698809
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.47327829
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47327829
60GATA4_21415370_ChIP-Seq_HL-1_Mouse1.44983308
61NCOR_22424771_ChIP-Seq_293T_Human1.44007881
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43451748
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43272193
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41486066
65FOXP3_21729870_ChIP-Seq_TREG_Human1.41047700
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38524038
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38077364
68VDR_22108803_ChIP-Seq_LS180_Human1.35281656
69AR_20517297_ChIP-Seq_VCAP_Human1.34922454
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34172964
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32413753
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31757425
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.31650222
74DCP1A_22483619_ChIP-Seq_HELA_Human1.31439873
75P300_19829295_ChIP-Seq_ESCs_Human1.31305136
76P53_21459846_ChIP-Seq_SAOS-2_Human1.31063807
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29658060
78AR_21572438_ChIP-Seq_LNCaP_Human1.28247619
79REST_21632747_ChIP-Seq_MESCs_Mouse1.28013367
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27312238
81STAT3_23295773_ChIP-Seq_U87_Human1.26042458
82BCAT_22108803_ChIP-Seq_LS180_Human1.25887962
83* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25053157
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25039973
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24681245
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24403765
87GABP_19822575_ChIP-Seq_HepG2_Human1.23888440
88TAF2_19829295_ChIP-Seq_ESCs_Human1.23423777
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23411364
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22916654
91CBP_20019798_ChIP-Seq_JUKART_Human1.22664505
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22664505
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.22566294
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21886886
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21699983
96NANOG_19829295_ChIP-Seq_ESCs_Human1.20084212
97SOX2_19829295_ChIP-Seq_ESCs_Human1.20084212
98ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19982134
99TCF4_23295773_ChIP-Seq_U87_Human1.19937171
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19691576
101TAF15_26573619_Chip-Seq_HEK293_Human1.17872910
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.17566273
103AR_25329375_ChIP-Seq_VCAP_Human1.16974592
104MYC_19829295_ChIP-Seq_ESCs_Human1.16808576
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16502682
106OCT4_20526341_ChIP-Seq_ESCs_Human1.16295428
107NANOG_20526341_ChIP-Seq_ESCs_Human1.14872708
108TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14602648
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13131435
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13131435
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12450477
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11854268
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.11591914
114IGF1R_20145208_ChIP-Seq_DFB_Human1.10245072
115NFE2_27457419_Chip-Seq_LIVER_Mouse1.09946428
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09546446
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08067569
118TCF4_22108803_ChIP-Seq_LS180_Human1.08062967
119MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07546470
120SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06628528
121RNF2_27304074_Chip-Seq_NSC_Mouse1.05959217
122MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05893306
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05688492
124RAC3_21632823_ChIP-Seq_H3396_Human1.05591116
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05475671
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05055599
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.04686755
128PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03861606
129* E2F1_20622854_ChIP-Seq_HELA_Human1.02794623
130POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02192410
131RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01931942
132KDM5A_27292631_Chip-Seq_BREAST_Human1.01861863
133SOX9_26525672_Chip-Seq_HEART_Mouse1.01690216
134TTF2_22483619_ChIP-Seq_HELA_Human1.01507274
135P53_22387025_ChIP-Seq_ESCs_Mouse1.00812506
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00528901
137ER_23166858_ChIP-Seq_MCF-7_Human0.99167633
138SMAD_19615063_ChIP-ChIP_OVARY_Human0.98873473
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98136961
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98064208
141TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97836677
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97396440
143FOXH1_21741376_ChIP-Seq_ESCs_Human0.97100166
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.96233765
145E2F1_21310950_ChIP-Seq_MCF-7_Human0.96115957
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95969749
147FOXH1_21741376_ChIP-Seq_EPCs_Human0.95778349
148SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95345377
149SMAD4_21799915_ChIP-Seq_A2780_Human0.95239156
150KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94104207
151* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93482473
152TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93332828
153MYC_18940864_ChIP-ChIP_HL60_Human0.93113805
154* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92621890
155SOX2_18555785_Chip-Seq_ESCs_Mouse0.92428306
156NMYC_18555785_Chip-Seq_ESCs_Mouse0.92230567
157AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91968970
158NANOG_16153702_ChIP-ChIP_HESCs_Human0.91768673
159NANOG_18555785_Chip-Seq_ESCs_Mouse0.91338801
160RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90989390
161TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90988369
162RUNX2_22187159_ChIP-Seq_PCA_Human0.90317731
163WDR5_24793694_ChIP-Seq_LNCAP_Human0.87606320
164DROSHA_22980978_ChIP-Seq_HELA_Human0.87188927

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation3.37172160
2MP0000372_irregular_coat_pigmentation2.99026359
3MP0000749_muscle_degeneration2.88596564
4MP0003122_maternal_imprinting2.86766726
5MP0004043_abnormal_pH_regulation2.68065020
6MP0003136_yellow_coat_color2.66867950
7MP0008007_abnormal_cellular_replicative2.64352195
8MP0003123_paternal_imprinting2.60115881
9MP0008875_abnormal_xenobiotic_pharmacok2.58869015
10MP0003121_genomic_imprinting2.54907044
11MP0001986_abnormal_taste_sensitivity2.52847954
12MP0003787_abnormal_imprinting2.52741656
13MP0002837_dystrophic_cardiac_calcinosis2.52099311
14MP0005451_abnormal_body_composition2.50893189
15MP0003195_calcinosis2.48943286
16MP0008058_abnormal_DNA_repair2.41853233
17MP0005409_darkened_coat_color2.33092074
18MP0005551_abnormal_eye_electrophysiolog2.25081682
19MP0005646_abnormal_pituitary_gland2.20537803
20MP0010094_abnormal_chromosome_stability2.20221795
21MP0000015_abnormal_ear_pigmentation2.14840176
22MP0004084_abnormal_cardiac_muscle2.13548221
23MP0000566_synostosis2.12876935
24MP0002132_abnormal_respiratory_system2.10910778
25MP0008872_abnormal_physiological_respon2.06038125
26MP0002102_abnormal_ear_morphology2.05005745
27MP0005670_abnormal_white_adipose2.03157498
28MP0001188_hyperpigmentation2.00997754
29MP0000569_abnormal_digit_pigmentation1.99390336
30MP0000427_abnormal_hair_cycle1.98421780
31MP0002163_abnormal_gland_morphology1.92166713
32MP0000516_abnormal_urinary_system1.89707405
33MP0005367_renal/urinary_system_phenotyp1.89707405
34MP0005174_abnormal_tail_pigmentation1.89579691
35MP0006292_abnormal_olfactory_placode1.89399567
36MP0000383_abnormal_hair_follicle1.86741311
37MP0005645_abnormal_hypothalamus_physiol1.83457343
38MP0003786_premature_aging1.75652528
39MP0008877_abnormal_DNA_methylation1.73741088
40MP0003693_abnormal_embryo_hatching1.73054627
41MP0004782_abnormal_surfactant_physiolog1.72268150
42MP0005171_absent_coat_pigmentation1.69838498
43MP0002735_abnormal_chemical_nociception1.68130999
44MP0003941_abnormal_skin_development1.66501544
45MP0004133_heterotaxia1.62817102
46MP0002972_abnormal_cardiac_muscle1.61179751
47MP0002127_abnormal_cardiovascular_syste1.57250980
48MP0008961_abnormal_basal_metabolism1.56480251
49MP0004142_abnormal_muscle_tone1.54289722
50MP0008057_abnormal_DNA_replication1.50576761
51MP0009745_abnormal_behavioral_response1.49489127
52MP0004885_abnormal_endolymph1.47443973
53MP0002653_abnormal_ependyma_morphology1.41290723
54MP0009046_muscle_twitch1.40983597
55MP0001919_abnormal_reproductive_system1.40484318
56MP0002234_abnormal_pharynx_morphology1.39924400
57MP0003315_abnormal_perineum_morphology1.36629027
58MP0008995_early_reproductive_senescence1.35138303
59MP0003950_abnormal_plasma_membrane1.34886937
60MP0003111_abnormal_nucleus_morphology1.33381620
61MP0002876_abnormal_thyroid_physiology1.32826478
62MP0006036_abnormal_mitochondrial_physio1.30733213
63MP0003646_muscle_fatigue1.29351810
64MP0006072_abnormal_retinal_apoptosis1.28638861
65MP0005330_cardiomyopathy1.27526909
66MP0005253_abnormal_eye_physiology1.26700857
67MP0001501_abnormal_sleep_pattern1.25723656
68MP0004147_increased_porphyrin_level1.25719143
69MP0004215_abnormal_myocardial_fiber1.25578347
70MP0001502_abnormal_circadian_rhythm1.25440452
71MP0003077_abnormal_cell_cycle1.24643225
72MP0002736_abnormal_nociception_after1.24195470
73MP0005408_hypopigmentation1.23431097
74MP0005083_abnormal_biliary_tract1.22811002
75MP0002160_abnormal_reproductive_system1.22651823
76MP0004381_abnormal_hair_follicle1.19697392
77MP0002938_white_spotting1.17633137
78MP0004036_abnormal_muscle_relaxation1.17273953
79MP0000049_abnormal_middle_ear1.17174349
80MP0002751_abnormal_autonomic_nervous1.15094195
81MP0004742_abnormal_vestibular_system1.13477587
82MP0001186_pigmentation_phenotype1.11065788
83MP0003137_abnormal_impulse_conducting1.08609499
84MP0008004_abnormal_stomach_pH1.08262633
85MP0010030_abnormal_orbit_morphology1.08133506
86MP0001873_stomach_inflammation1.08071149
87MP0003186_abnormal_redox_activity1.07594709
88MP0005620_abnormal_muscle_contractility1.06724775
89MP0001177_atelectasis1.06345407
90MP0003828_pulmonary_edema1.06317780
91MP0010678_abnormal_skin_adnexa1.05606032
92MP0002272_abnormal_nervous_system1.05374642
93MP0000647_abnormal_sebaceous_gland1.05193252
94MP0002557_abnormal_social/conspecific_i1.04701945
95MP0003878_abnormal_ear_physiology1.03740524
96MP0005377_hearing/vestibular/ear_phenot1.03740524
97MP0001485_abnormal_pinna_reflex1.03685857
98MP0003943_abnormal_hepatobiliary_system1.00007755
99MP0004924_abnormal_behavior0.99549551
100MP0005386_behavior/neurological_phenoty0.99549551
101MP0004484_altered_response_of0.99217373
102MP0005423_abnormal_somatic_nervous0.98441697
103MP0002210_abnormal_sex_determination0.97277870
104MP0004085_abnormal_heartbeat0.96869061
105MP0002733_abnormal_thermal_nociception0.96683260
106MP0001970_abnormal_pain_threshold0.95617111
107MP0001764_abnormal_homeostasis0.95487613
108MP0003718_maternal_effect0.94537770
109MP0003221_abnormal_cardiomyocyte_apopto0.94274996
110MP0002572_abnormal_emotion/affect_behav0.94003331
111MP0002098_abnormal_vibrissa_morphology0.93523400
112MP0005332_abnormal_amino_acid0.93484687
113MP0002734_abnormal_mechanical_nocicepti0.93482065
114MP0003698_abnormal_male_reproductive0.92581532
115MP0000681_abnormal_thyroid_gland0.91518392
116MP0001664_abnormal_digestion0.91320753
117MP0003011_delayed_dark_adaptation0.90228447
118MP0000538_abnormal_urinary_bladder0.90096632
119MP0002075_abnormal_coat/hair_pigmentati0.89718891
120MP0008932_abnormal_embryonic_tissue0.89037263
121MP0003567_abnormal_fetal_cardiomyocyte0.88955844
122MP0001486_abnormal_startle_reflex0.87265888
123MP0001119_abnormal_female_reproductive0.87060823
124MP0005195_abnormal_posterior_eye0.86848801
125MP0010386_abnormal_urinary_bladder0.86721358
126MP0010329_abnormal_lipoprotein_level0.86489374
127MP0001324_abnormal_eye_pigmentation0.86314377
128MP0001544_abnormal_cardiovascular_syste0.86032138
129MP0005385_cardiovascular_system_phenoty0.86032138
130MP0008789_abnormal_olfactory_epithelium0.85940184
131MP0001929_abnormal_gametogenesis0.84675418
132MP0002693_abnormal_pancreas_physiology0.84288837
133MP0000470_abnormal_stomach_morphology0.83100322
134MP0005379_endocrine/exocrine_gland_phen0.82168815
135MP0006035_abnormal_mitochondrial_morpho0.81945956
136MP0001968_abnormal_touch/_nociception0.81158466
137MP0002638_abnormal_pupillary_reflex0.80904708
138MP0010630_abnormal_cardiac_muscle0.80841525
139MP0001765_abnormal_ion_homeostasis0.80688502
140MP0002095_abnormal_skin_pigmentation0.79929972
141MP0002064_seizures0.79605289
142MP0000371_diluted_coat_color0.79501620
143MP0003942_abnormal_urinary_system0.79208594
144MP0005248_abnormal_Harderian_gland0.78203074
145MP0006138_congestive_heart_failure0.77545579
146MP0004130_abnormal_muscle_cell0.77295658
147MP0003385_abnormal_body_wall0.76503235
148MP0008775_abnormal_heart_ventricle0.76015485
149MP0005410_abnormal_fertilization0.75960378
150MP0000230_abnormal_systemic_arterial0.75679373
151MP0002877_abnormal_melanocyte_morpholog0.75525604
152MP0006276_abnormal_autonomic_nervous0.74761927
153MP0005389_reproductive_system_phenotype0.74448876
154MP0002396_abnormal_hematopoietic_system0.74209770
155MP0002277_abnormal_respiratory_mucosa0.73167572
156MP0005075_abnormal_melanosome_morpholog0.72170258
157MP0001542_abnormal_bone_strength0.70469421
158MP0009250_abnormal_appendicular_skeleto0.68602369
159MP0000631_abnormal_neuroendocrine_gland0.68403916
160MP0003172_abnormal_lysosome_physiology0.68175596
161MP0001984_abnormal_olfaction0.67083083
162MP0000678_abnormal_parathyroid_gland0.67009359
163MP0004145_abnormal_muscle_electrophysio0.65995215
164MP0003755_abnormal_palate_morphology0.65784882

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)3.86934573
2Abnormal hair whorl (HP:0010721)3.82226939
3Pheochromocytoma (HP:0002666)3.63123612
4Molar tooth sign on MRI (HP:0002419)3.53496509
5Abnormality of midbrain morphology (HP:0002418)3.53496509
6Acute necrotizing encephalopathy (HP:0006965)3.46954322
7Type II lissencephaly (HP:0007260)3.46487669
8Neuroendocrine neoplasm (HP:0100634)3.36055873
9Abnormality of alanine metabolism (HP:0010916)3.26958018
10Hyperalaninemia (HP:0003348)3.26958018
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.26958018
12Nephronophthisis (HP:0000090)3.24360673
13Febrile seizures (HP:0002373)3.21331955
14Abnormality of incisor morphology (HP:0011063)3.18835367
15Abnormal mitochondria in muscle tissue (HP:0008316)3.17028897
16Hypoplastic left heart (HP:0004383)3.16338989
17Increased CSF lactate (HP:0002490)3.13837082
18Abnormality of the renal cortex (HP:0011035)3.10153372
19Tubular atrophy (HP:0000092)3.09146813
20Neoplasm of the adrenal gland (HP:0100631)3.06251960
21Aplasia/Hypoplasia of the fovea (HP:0008060)2.97750347
22Hypoplasia of the fovea (HP:0007750)2.97750347
23True hermaphroditism (HP:0010459)2.94273049
24Cystic liver disease (HP:0006706)2.93178924
25Mitochondrial inheritance (HP:0001427)2.89900748
26Abnormality of the renal medulla (HP:0100957)2.88111169
27Progressive macrocephaly (HP:0004481)2.83307045
28Attenuation of retinal blood vessels (HP:0007843)2.82870999
29Distal lower limb muscle weakness (HP:0009053)2.80420864
30Hyperventilation (HP:0002883)2.77540541
31Hypoplastic heart (HP:0001961)2.77353312
32Pendular nystagmus (HP:0012043)2.77177866
33Osteomalacia (HP:0002749)2.76099796
34Hepatocellular necrosis (HP:0001404)2.73425261
35Concave nail (HP:0001598)2.73026750
36Cerebellar dysplasia (HP:0007033)2.70728155
37Type I transferrin isoform profile (HP:0003642)2.68361116
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.67603332
39Hypothermia (HP:0002045)2.66390814
40Patent foramen ovale (HP:0001655)2.63940874
41Chromsome breakage (HP:0040012)2.61735716
42Abnormal biliary tract physiology (HP:0012439)2.60106642
43Bile duct proliferation (HP:0001408)2.60106642
44Hepatic necrosis (HP:0002605)2.60052988
45Exercise intolerance (HP:0003546)2.56348956
46Atrial fibrillation (HP:0005110)2.56288305
47Abnormality of the pons (HP:0007361)2.55951729
48Acute encephalopathy (HP:0006846)2.55227424
49Patellar aplasia (HP:0006443)2.54977626
50Protruding tongue (HP:0010808)2.51962989
51Hypoplasia of the pons (HP:0012110)2.50930528
52Alopecia of scalp (HP:0002293)2.49366641
53Abnormality of the renal collecting system (HP:0004742)2.48909066
54Pancreatic fibrosis (HP:0100732)2.48379160
55Polydipsia (HP:0001959)2.48356345
56Abnormal drinking behavior (HP:0030082)2.48356345
57Duplicated collecting system (HP:0000081)2.47716665
58Microvesicular hepatic steatosis (HP:0001414)2.45390080
59Furrowed tongue (HP:0000221)2.45118042
60Large for gestational age (HP:0001520)2.44988671
61Lissencephaly (HP:0001339)2.44636503
62Aplasia/Hypoplasia of the patella (HP:0006498)2.44351737
63Increased serum lactate (HP:0002151)2.41159216
64Abolished electroretinogram (ERG) (HP:0000550)2.39197532
65Abnormal rod and cone electroretinograms (HP:0008323)2.38507551
66Inability to walk (HP:0002540)2.35559218
67Abnormality of the fovea (HP:0000493)2.34409186
68Abnormality of glycolysis (HP:0004366)2.33836893
69Increased serum pyruvate (HP:0003542)2.33836893
70Exercise-induced muscle cramps (HP:0003710)2.31932259
71Intestinal fistula (HP:0100819)2.31562551
72Abnormality of the columella (HP:0009929)2.30874820
73Rectal fistula (HP:0100590)2.28695210
74Rectovaginal fistula (HP:0000143)2.28695210
75Clumsiness (HP:0002312)2.27668727
76Primary atrial arrhythmia (HP:0001692)2.25799574
77Meckel diverticulum (HP:0002245)2.25628350
78Occipital encephalocele (HP:0002085)2.25548203
79Sclerocornea (HP:0000647)2.25465113
80Severe muscular hypotonia (HP:0006829)2.24891905
81Supraventricular tachycardia (HP:0004755)2.23759639
82Abnormal number of erythroid precursors (HP:0012131)2.21024676
83Progressive inability to walk (HP:0002505)2.16835221
84Embryonal renal neoplasm (HP:0011794)2.15610816
85Broad-based gait (HP:0002136)2.14814786
86Abnormality of the ileum (HP:0001549)2.14606129
87Nephroblastoma (Wilms tumor) (HP:0002667)2.12516748
88Progressive sensorineural hearing impairment (HP:0000408)2.11953288
89Supraventricular arrhythmia (HP:0005115)2.11285256
90Nephrogenic diabetes insipidus (HP:0009806)2.09221620
91Ketosis (HP:0001946)2.07794210
92Aplasia/Hypoplasia of the macula (HP:0008059)2.07327413
93Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05871503
94Lactic acidosis (HP:0003128)2.05563302
95Abnormality of the preputium (HP:0100587)2.05411202
96Congenital, generalized hypertrichosis (HP:0004540)2.05202017
97Follicular hyperkeratosis (HP:0007502)2.04503401
98Type 2 muscle fiber atrophy (HP:0003554)2.03156710
99Polyuria (HP:0000103)2.03031907
100Short chin (HP:0000331)2.01986503
101Anencephaly (HP:0002323)2.01454239
102Congenital hepatic fibrosis (HP:0002612)1.98388036
103Aplasia/Hypoplasia of the uvula (HP:0010293)1.98108198
104Aplasia/Hypoplasia of the tibia (HP:0005772)1.97812056
105Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96084705
106Bony spicule pigmentary retinopathy (HP:0007737)1.95855959
107Chronic hepatic failure (HP:0100626)1.95131675
108Medial flaring of the eyebrow (HP:0010747)1.94874584
109Subaortic stenosis (HP:0001682)1.94456509
110Abnormality of the left ventricular outflow tract (HP:0011103)1.94456509
111Alveolar cell carcinoma (HP:0006519)1.93521974
112Respiratory failure (HP:0002878)1.93202487
113Abnormality of the calf musculature (HP:0001430)1.93119777
114Aplasia/Hypoplasia of the tongue (HP:0010295)1.90876497
115Male pseudohermaphroditism (HP:0000037)1.90445504
116Syringomyelia (HP:0003396)1.90112827
117Spinal cord lesions (HP:0100561)1.90112827
118Irregular epiphyses (HP:0010582)1.89505240
119Neoplasm of the peripheral nervous system (HP:0100007)1.89268496
120Abnormality of the incisor (HP:0000676)1.89040010
121Short middle phalanx of the 5th finger (HP:0004220)1.88944462
122Pancreatic cysts (HP:0001737)1.88910912
123Progressive microcephaly (HP:0000253)1.88687488
124Bilateral microphthalmos (HP:0007633)1.88298768
125Chorioretinal atrophy (HP:0000533)1.87719877
126Palpitations (HP:0001962)1.87498135
127Absent eyebrow (HP:0002223)1.85789376
128Ketoacidosis (HP:0001993)1.85454662
129Poor coordination (HP:0002370)1.85329119
130Meningioma (HP:0002858)1.85146031
131Hepatoblastoma (HP:0002884)1.84948510
132Dry hair (HP:0011359)1.83884983
133Diastasis recti (HP:0001540)1.83641307
134Decreased circulating renin level (HP:0003351)1.83489427
135Pachygyria (HP:0001302)1.83129352
136Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81794934
137Methylmalonic aciduria (HP:0012120)1.81739797
138Optic disc pallor (HP:0000543)1.81454439
139Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81114164
140Degeneration of anterior horn cells (HP:0002398)1.80702243
141Abnormality of the anterior horn cell (HP:0006802)1.80702243
142Absent thumb (HP:0009777)1.80238222
1433-Methylglutaconic aciduria (HP:0003535)1.80142724
144Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79485277
145Vaginal fistula (HP:0004320)1.79030646
146Decreased central vision (HP:0007663)1.78036982
147Lipoatrophy (HP:0100578)1.77904822
148Gaze-evoked nystagmus (HP:0000640)1.77470492
149Abnormality of chromosome stability (HP:0003220)1.76522298
150Abnormal protein N-linked glycosylation (HP:0012347)1.76515597
151Abnormal protein glycosylation (HP:0012346)1.76515597
152Abnormal glycosylation (HP:0012345)1.76515597
153Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76515597
154Congenital primary aphakia (HP:0007707)1.76268421
155Optic nerve hypoplasia (HP:0000609)1.76195797
156Renal cortical cysts (HP:0000803)1.75533303
157Preaxial hand polydactyly (HP:0001177)1.75355263
158Rib fusion (HP:0000902)1.75224129
159Adrenal hypoplasia (HP:0000835)1.74564229
160Optic nerve coloboma (HP:0000588)1.73843450
161Amelogenesis imperfecta (HP:0000705)1.73426570
162Postaxial foot polydactyly (HP:0001830)1.73317160
163Tachypnea (HP:0002789)1.73260005
164Hyperglycinuria (HP:0003108)1.72387439
165Gait imbalance (HP:0002141)1.71962941
166Epileptic encephalopathy (HP:0200134)1.71859452
167Exercise-induced myalgia (HP:0003738)1.71842249
168Lipid accumulation in hepatocytes (HP:0006561)1.71254598
169Genetic anticipation (HP:0003743)1.71245549
170Melanoma (HP:0002861)1.71234699
171Methylmalonic acidemia (HP:0002912)1.70791727
172Abnormality of renin-angiotensin system (HP:0000847)1.70469034
173Birth length less than 3rd percentile (HP:0003561)1.69795461
174Neoplasm of the tracheobronchial system (HP:0100552)1.67762103
175Stomach cancer (HP:0012126)1.67740553
176Rimmed vacuoles (HP:0003805)1.66947291
177Abnormality of DNA repair (HP:0003254)1.66730875
178Abnormality of the nasolacrimal system (HP:0000614)1.66241642
179Dynein arm defect of respiratory motile cilia (HP:0012255)1.66013035

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK26.79141619
2FRK5.65950988
3MKNK14.59064609
4TNIK4.06923376
5TLK13.71949912
6ZAK3.28827871
7AKT33.20558454
8CASK3.18265807
9WNK42.89869352
10MAP2K72.48138866
11OBSCN2.46070058
12GRK12.36164200
13STK38L2.29956370
14TAOK32.26515426
15MYLK2.16093646
16STK242.15857399
17SRPK12.10441610
18MAP4K22.03154884
19SIK32.01466939
20PRPF4B2.00675622
21WNK31.99925135
22SGK21.79906148
23ERBB31.78068254
24TSSK61.77941825
25MAPKAPK31.62722975
26PLK21.61308349
27PIK3CA1.61265847
28DAPK21.59283199
29STK391.51018096
30STK161.49625437
31MAP2K61.46608780
32CDK81.40421767
33BMPR1B1.38893578
34PHKG11.38799157
35PHKG21.38799157
36NEK61.35107966
37MAPK151.32275938
38OXSR11.30244608
39BCKDK1.28911713
40BMPR21.27186558
41EPHA21.21381203
42MAP3K121.19536745
43EIF2AK21.17749472
44SGK31.17619849
45PLK31.15169149
46BRSK21.12425086
47MAP3K141.12424918
48PLK41.12148174
49PRKCI1.08495104
50NEK21.06892361
51MST41.01725691
52MAPK130.99728299
53TXK0.98915267
54SGK2230.97601755
55SGK4940.97601755
56ACVR1B0.96483338
57TRIM280.95139194
58VRK10.93138716
59CCNB10.92114555
60IKBKB0.90005265
61YES10.87109457
62RPS6KB10.86690726
63PIM20.84237437
64CAMKK20.83607541
65BUB10.83402357
66TAOK20.82944508
67PINK10.82501338
68EIF2AK30.81785730
69EIF2AK10.81780753
70CHUK0.81709467
71PRKCG0.80089577
72PAK30.79755884
73SIK20.78812875
74MAPKAPK50.77856274
75RPS6KA50.76732617
76BRAF0.75767448
77TAF10.75561545
78MAP3K40.73966434
79MARK10.73380165
80NTRK30.72086144
81ADRBK20.71115664
82VRK20.70628576
83TRPM70.69485193
84MUSK0.66515441
85CAMK1D0.62106160
86PDK20.62094940
87PNCK0.61232037
88NUAK10.60942362
89BCR0.60728377
90STK110.60472794
91BRSK10.59925645
92NEK90.56842156
93MAP3K30.56342049
94RPS6KC10.55789224
95RPS6KL10.55789224
96PRKCQ0.54673256
97ATR0.54103615
98LMTK20.50773158
99WEE10.50552163
100PKN10.50081714
101PLK10.49540094
102RPS6KA20.48742501
103MAP2K20.48648405
104RPS6KA60.48470542
105NEK10.47530498
106IRAK30.47513916
107PRKAA20.47226415
108MAP3K70.45351795
109PRKAA10.45064258
110IRAK10.45056820
111PDK40.44540600
112PDK30.44540600
113PRKCE0.44465149
114CAMK10.44205415
115PRKACA0.43942992
116TNK20.43722659
117MAPK110.43124400
118EPHA30.42695663
119NME10.40834132
120CSNK1A10.40567666
121ITK0.40425257
122GRK70.40123429
123LIMK10.39869862
124BRD40.39705242
125KIT0.39258887
126MAP2K10.37700679
127AURKA0.37589216
128ERBB20.37475625
129STK30.37002563
130TIE10.36897231
131NTRK20.36046809
132CHEK20.35577177
133CSNK2A10.34505953
134PRKCZ0.33477124
135PIM10.33348315
136MAP2K40.33249677
137PRKG20.32957467
138MST1R0.32908137
139CAMK2A0.32523800
140CDK30.32406126
141ATM0.32373186
142CSNK1A1L0.32169132
143CSNK1D0.30909183
144CDC42BPA0.30805200
145CAMK40.30567097
146PRKCA0.29358913
147MET0.28854043
148MAP2K30.28179178
149CSNK1G30.27763212
150ERBB40.27015918
151MAP3K60.26804995
152FGFR20.26799117
153TESK10.26314445
154SGK10.26166934
155DYRK20.26103481
156TGFBR10.25318623
157PRKACB0.24609936
158MAPK70.24469675
159INSRR0.22438882
160ADRBK10.22403817
161MINK10.21844410
162DAPK10.20871447
163STK40.20112744

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.46434104
2Oxidative phosphorylation_Homo sapiens_hsa001903.11183937
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.09760391
4Proteasome_Homo sapiens_hsa030503.07823185
5Linoleic acid metabolism_Homo sapiens_hsa005912.97262401
6Parkinsons disease_Homo sapiens_hsa050122.75385966
7Mismatch repair_Homo sapiens_hsa034302.65375356
8Nitrogen metabolism_Homo sapiens_hsa009102.64477380
9RNA polymerase_Homo sapiens_hsa030202.49071198
10Selenocompound metabolism_Homo sapiens_hsa004502.45677536
11DNA replication_Homo sapiens_hsa030302.42839516
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35339381
13Huntingtons disease_Homo sapiens_hsa050162.32150125
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19162063
15Homologous recombination_Homo sapiens_hsa034402.18950457
16Sulfur relay system_Homo sapiens_hsa041222.16396019
17Butanoate metabolism_Homo sapiens_hsa006502.15210770
18Cardiac muscle contraction_Homo sapiens_hsa042602.13505700
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.06326883
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90586107
21Fanconi anemia pathway_Homo sapiens_hsa034601.89628709
22Base excision repair_Homo sapiens_hsa034101.87213547
23Ether lipid metabolism_Homo sapiens_hsa005651.84812234
24RNA degradation_Homo sapiens_hsa030181.81283905
25Nucleotide excision repair_Homo sapiens_hsa034201.80766148
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.80219712
27One carbon pool by folate_Homo sapiens_hsa006701.77803192
28Alzheimers disease_Homo sapiens_hsa050101.74225162
29Pyrimidine metabolism_Homo sapiens_hsa002401.71651971
30Non-homologous end-joining_Homo sapiens_hsa034501.69840052
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68630101
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67908894
33RNA transport_Homo sapiens_hsa030131.66432496
34Basal transcription factors_Homo sapiens_hsa030221.66350412
35Cell cycle_Homo sapiens_hsa041101.61518994
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54793674
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51252201
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49556651
39Tryptophan metabolism_Homo sapiens_hsa003801.47505611
40Purine metabolism_Homo sapiens_hsa002301.43055618
41Protein export_Homo sapiens_hsa030601.39115722
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37920768
43ABC transporters_Homo sapiens_hsa020101.35609624
44Ovarian steroidogenesis_Homo sapiens_hsa049131.34032453
45Spliceosome_Homo sapiens_hsa030401.33961631
46Caffeine metabolism_Homo sapiens_hsa002321.32279464
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27480329
48Fructose and mannose metabolism_Homo sapiens_hsa000511.24394683
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24137296
50Collecting duct acid secretion_Homo sapiens_hsa049661.21678180
51Galactose metabolism_Homo sapiens_hsa000521.20859682
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.20760967
53Dilated cardiomyopathy_Homo sapiens_hsa054141.17289121
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16191117
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08639498
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06532690
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05822433
58Carbon metabolism_Homo sapiens_hsa012001.03581483
59Peroxisome_Homo sapiens_hsa041461.00162212
60Chemical carcinogenesis_Homo sapiens_hsa052040.96494606
61Synaptic vesicle cycle_Homo sapiens_hsa047210.96243357
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93254884
63Autoimmune thyroid disease_Homo sapiens_hsa053200.92553715
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.91158303
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89446433
66Vibrio cholerae infection_Homo sapiens_hsa051100.89436254
67Morphine addiction_Homo sapiens_hsa050320.85097648
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84933702
69mRNA surveillance pathway_Homo sapiens_hsa030150.84608791
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83313408
71Arachidonic acid metabolism_Homo sapiens_hsa005900.81927263
72p53 signaling pathway_Homo sapiens_hsa041150.81685071
73Histidine metabolism_Homo sapiens_hsa003400.80531649
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.76822100
75Olfactory transduction_Homo sapiens_hsa047400.76324011
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75753789
77Insulin secretion_Homo sapiens_hsa049110.75316600
78Nicotine addiction_Homo sapiens_hsa050330.74227961
79Taste transduction_Homo sapiens_hsa047420.73695444
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72761821
81Biosynthesis of amino acids_Homo sapiens_hsa012300.72154743
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70551683
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68941279
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68729680
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68363512
86Epstein-Barr virus infection_Homo sapiens_hsa051690.68043116
87Retinol metabolism_Homo sapiens_hsa008300.67691649
88Metabolic pathways_Homo sapiens_hsa011000.67011699
89Regulation of autophagy_Homo sapiens_hsa041400.66772674
90Legionellosis_Homo sapiens_hsa051340.66656226
91HIF-1 signaling pathway_Homo sapiens_hsa040660.64972480
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.64208330
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63606196
94Lysine degradation_Homo sapiens_hsa003100.63223892
95Sulfur metabolism_Homo sapiens_hsa009200.62019189
96Fat digestion and absorption_Homo sapiens_hsa049750.61838172
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.61665225
98Vitamin digestion and absorption_Homo sapiens_hsa049770.61585993
99Primary immunodeficiency_Homo sapiens_hsa053400.61463852
100Mineral absorption_Homo sapiens_hsa049780.58885840
101Melanoma_Homo sapiens_hsa052180.57844678
102Circadian rhythm_Homo sapiens_hsa047100.56450134
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55827472
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.53353209
105Glycerolipid metabolism_Homo sapiens_hsa005610.53295388
106Rheumatoid arthritis_Homo sapiens_hsa053230.52243055
107Glutamatergic synapse_Homo sapiens_hsa047240.51238419
108Salivary secretion_Homo sapiens_hsa049700.51171229
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49021875
110Phagosome_Homo sapiens_hsa041450.48663929
111Type I diabetes mellitus_Homo sapiens_hsa049400.47054651
112Pyruvate metabolism_Homo sapiens_hsa006200.45791116
113Phenylalanine metabolism_Homo sapiens_hsa003600.43585423
114Ribosome_Homo sapiens_hsa030100.43304042
115Phototransduction_Homo sapiens_hsa047440.42820691
116Herpes simplex infection_Homo sapiens_hsa051680.42472695
117GABAergic synapse_Homo sapiens_hsa047270.40553744
118Steroid biosynthesis_Homo sapiens_hsa001000.40132251
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.38600384
120Fatty acid elongation_Homo sapiens_hsa000620.38244661
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37885223
122Fatty acid biosynthesis_Homo sapiens_hsa000610.37317221
123Tyrosine metabolism_Homo sapiens_hsa003500.36857578
124Propanoate metabolism_Homo sapiens_hsa006400.36665802
125TGF-beta signaling pathway_Homo sapiens_hsa043500.35090403
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33932898
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32437078
128Sphingolipid metabolism_Homo sapiens_hsa006000.31026321
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30439651
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29433338
131Dorso-ventral axis formation_Homo sapiens_hsa043200.28602580
132N-Glycan biosynthesis_Homo sapiens_hsa005100.28248924
133Thyroid cancer_Homo sapiens_hsa052160.27916079
134Influenza A_Homo sapiens_hsa051640.27664189
135Serotonergic synapse_Homo sapiens_hsa047260.24568871
136Circadian entrainment_Homo sapiens_hsa047130.23685992
137Oocyte meiosis_Homo sapiens_hsa041140.21846966
138beta-Alanine metabolism_Homo sapiens_hsa004100.20890687
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.20703918
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.20427323
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18584909
142Hippo signaling pathway_Homo sapiens_hsa043900.18574254
143Arginine and proline metabolism_Homo sapiens_hsa003300.18348268
144Calcium signaling pathway_Homo sapiens_hsa040200.18267736
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18099310
146HTLV-I infection_Homo sapiens_hsa051660.16472955

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