RDH16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.83995969
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.50724182
3L-phenylalanine catabolic process (GO:0006559)7.50724182
4omega-hydroxylase P450 pathway (GO:0097267)7.48123434
5L-phenylalanine metabolic process (GO:0006558)7.20080559
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.20080559
7aromatic amino acid family catabolic process (GO:0009074)6.96026518
8indole-containing compound catabolic process (GO:0042436)6.41571694
9indolalkylamine catabolic process (GO:0046218)6.41571694
10tryptophan catabolic process (GO:0006569)6.41571694
11oxidative demethylation (GO:0070989)6.40999088
12kynurenine metabolic process (GO:0070189)6.06584156
13tryptophan metabolic process (GO:0006568)6.06092025
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.99850564
15glyoxylate metabolic process (GO:0046487)5.88438755
16bile acid biosynthetic process (GO:0006699)5.76302614
17alpha-linolenic acid metabolic process (GO:0036109)5.70783917
18phenylpropanoid metabolic process (GO:0009698)5.54526774
19cysteine metabolic process (GO:0006534)5.52729538
20urea cycle (GO:0000050)5.38919540
21urea metabolic process (GO:0019627)5.38919540
22serine family amino acid catabolic process (GO:0009071)5.26137895
23sulfur amino acid catabolic process (GO:0000098)5.24283021
24high-density lipoprotein particle remodeling (GO:0034375)5.20792455
25lysine metabolic process (GO:0006553)5.14902136
26lysine catabolic process (GO:0006554)5.14902136
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.12375939
28blood coagulation, intrinsic pathway (GO:0007597)5.11427466
29aromatic amino acid family metabolic process (GO:0009072)5.09136175
30homocysteine metabolic process (GO:0050667)5.04187325
31nitrogen cycle metabolic process (GO:0071941)4.98481306
32bile acid metabolic process (GO:0008206)4.97273579
33negative regulation of fibrinolysis (GO:0051918)4.94403245
34amino-acid betaine metabolic process (GO:0006577)4.89326183
35peptidyl-glutamic acid carboxylation (GO:0017187)4.88711374
36protein carboxylation (GO:0018214)4.88711374
37tyrosine metabolic process (GO:0006570)4.77958174
38negative regulation of protein activation cascade (GO:2000258)4.77625786
39regulation of fibrinolysis (GO:0051917)4.76844381
40alpha-amino acid catabolic process (GO:1901606)4.73568856
41S-adenosylmethionine metabolic process (GO:0046500)4.72472321
42alkaloid metabolic process (GO:0009820)4.72184650
43cellular ketone body metabolic process (GO:0046950)4.68321843
44regulation of cholesterol esterification (GO:0010872)4.65484928
45drug catabolic process (GO:0042737)4.61199479
46complement activation, alternative pathway (GO:0006957)4.59166385
47indolalkylamine metabolic process (GO:0006586)4.58637672
48regulation of triglyceride catabolic process (GO:0010896)4.55644958
49regulation of protein activation cascade (GO:2000257)4.55265359
50amine catabolic process (GO:0009310)4.52111277
51cellular biogenic amine catabolic process (GO:0042402)4.52111277
52negative regulation of cholesterol transport (GO:0032375)4.51540741
53negative regulation of sterol transport (GO:0032372)4.51540741
54reverse cholesterol transport (GO:0043691)4.50898140
55ethanol metabolic process (GO:0006067)4.46322275
56plasma lipoprotein particle remodeling (GO:0034369)4.45614551
57protein-lipid complex remodeling (GO:0034368)4.45614551
58macromolecular complex remodeling (GO:0034367)4.45614551
59cellular glucuronidation (GO:0052695)4.41332590
60triglyceride homeostasis (GO:0070328)4.40168453
61acylglycerol homeostasis (GO:0055090)4.40168453
62negative regulation of complement activation (GO:0045916)4.39183047
63cellular amino acid catabolic process (GO:0009063)4.38777621
64phospholipid efflux (GO:0033700)4.37920194
65bile acid and bile salt transport (GO:0015721)4.32588875
66serine family amino acid metabolic process (GO:0009069)4.32242782
67protein activation cascade (GO:0072376)4.31281624
68glutamate metabolic process (GO:0006536)4.28673922
69glycine metabolic process (GO:0006544)4.27634171
70benzene-containing compound metabolic process (GO:0042537)4.25686395
71coenzyme catabolic process (GO:0009109)4.23654088
72drug transmembrane transport (GO:0006855)4.23481288
73regulation of complement activation (GO:0030449)4.21613148
74cellular modified amino acid catabolic process (GO:0042219)4.13868542
75urate metabolic process (GO:0046415)4.13593014
76imidazole-containing compound metabolic process (GO:0052803)4.12426070
77short-chain fatty acid metabolic process (GO:0046459)4.11253223
78ethanol oxidation (GO:0006069)4.08051305
79aldehyde catabolic process (GO:0046185)4.06260374
80serine family amino acid biosynthetic process (GO:0009070)4.05175012
81ketone body metabolic process (GO:1902224)4.04863132
82complement activation (GO:0006956)4.02023843
83plasma lipoprotein particle clearance (GO:0034381)4.01313591
84glucuronate metabolic process (GO:0019585)4.00693332
85uronic acid metabolic process (GO:0006063)4.00693332
86exogenous drug catabolic process (GO:0042738)3.96519535
87cholesterol efflux (GO:0033344)3.95387269
88xenobiotic catabolic process (GO:0042178)3.94995748
89regulation of humoral immune response (GO:0002920)3.93978331
90dicarboxylic acid biosynthetic process (GO:0043650)3.93302685
91carboxylic acid catabolic process (GO:0046395)3.90404827
92organic acid catabolic process (GO:0016054)3.90404827
93complement activation, classical pathway (GO:0006958)3.89032749
94arginine metabolic process (GO:0006525)3.88411339
95acetyl-CoA metabolic process (GO:0006084)3.86040749
96low-density lipoprotein particle remodeling (GO:0034374)3.85586903
97opsonization (GO:0008228)3.76847223
98negative regulation of blood coagulation (GO:0030195)3.74355031
99negative regulation of hemostasis (GO:1900047)3.74355031
100regulation of plasminogen activation (GO:0010755)3.73503921
101regulation of bile acid biosynthetic process (GO:0070857)3.73375447
102NAD biosynthetic process (GO:0009435)3.73371012
103plasma lipoprotein particle assembly (GO:0034377)3.72462127
104flavonoid metabolic process (GO:0009812)3.71059491
105aspartate family amino acid catabolic process (GO:0009068)3.70123911
106nicotinamide nucleotide biosynthetic process (GO:0019359)3.69201606
107pyridine nucleotide biosynthetic process (GO:0019363)3.69201606
108carnitine metabolic process (GO:0009437)3.68118572
109drug metabolic process (GO:0017144)3.68007364
110amino acid salvage (GO:0043102)3.67791235
111L-methionine salvage (GO:0071267)3.67791235
112L-methionine biosynthetic process (GO:0071265)3.67791235
113phospholipid homeostasis (GO:0055091)3.67071083
114acute-phase response (GO:0006953)3.66918102
115fatty acid oxidation (GO:0019395)3.63928642
116fatty acid beta-oxidation (GO:0006635)3.63199403
117monocarboxylic acid catabolic process (GO:0072329)3.63133643
118positive regulation of lipoprotein lipase activity (GO:0051006)3.62617921
119positive regulation of triglyceride lipase activity (GO:0061365)3.62617921
120cytolysis (GO:0019835)3.62171687
121cofactor catabolic process (GO:0051187)3.61461603
122arginine catabolic process (GO:0006527)3.61184665
123fibrinolysis (GO:0042730)3.61033472
124negative regulation of lipase activity (GO:0060192)3.60570588
125positive regulation of lipid catabolic process (GO:0050996)3.59634106
126heme transport (GO:0015886)3.56138016
127xenobiotic metabolic process (GO:0006805)3.55393739
128negative regulation of wound healing (GO:0061045)3.41514940
129negative regulation of coagulation (GO:0050819)3.38176501
130negative regulation of humoral immune response (GO:0002921)3.36785443
131steroid catabolic process (GO:0006706)3.33086281
132disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.19948529
133killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.19948529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.33298941
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.07922481
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.02735316
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.45022408
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.18763485
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.07448536
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.62693988
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.07932654
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.89655222
10GBX2_23144817_ChIP-Seq_PC3_Human3.10954028
11IGF1R_20145208_ChIP-Seq_DFB_Human2.49012631
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45106989
13ZNF274_21170338_ChIP-Seq_K562_Hela2.40280785
14VDR_22108803_ChIP-Seq_LS180_Human2.34015692
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20315114
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16040977
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.14583722
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08977357
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5622213
20ER_23166858_ChIP-Seq_MCF-7_Human1.94606913
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93227916
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85778681
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.83261218
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73474139
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68388372
26P300_19829295_ChIP-Seq_ESCs_Human1.65938647
27HTT_18923047_ChIP-ChIP_STHdh_Human1.59745753
28STAT3_23295773_ChIP-Seq_U87_Human1.59266073
29CBP_20019798_ChIP-Seq_JUKART_Human1.56072008
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56072008
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55255221
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.51530421
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47876270
34SMAD4_21799915_ChIP-Seq_A2780_Human1.46051593
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46002440
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43106260
37* HNF4A_19822575_ChIP-Seq_HepG2_Human1.43061626
38* TCF4_23295773_ChIP-Seq_U87_Human1.42357944
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41949168
40FUS_26573619_Chip-Seq_HEK293_Human1.41754799
41TCF4_22108803_ChIP-Seq_LS180_Human1.36872135
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36431662
43SOX2_19829295_ChIP-Seq_ESCs_Human1.33334314
44NANOG_19829295_ChIP-Seq_ESCs_Human1.33334314
45CLOCK_20551151_ChIP-Seq_293T_Human1.31930984
46GATA1_22025678_ChIP-Seq_K562_Human1.29780579
47AR_25329375_ChIP-Seq_VCAP_Human1.29444055
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29428341
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26354401
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26082684
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25126146
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24510603
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22955367
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22755395
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21491588
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21441307
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.18780673
58RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16606703
59RUNX2_22187159_ChIP-Seq_PCA_Human1.16549395
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15916905
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.15721604
62P53_22387025_ChIP-Seq_ESCs_Mouse1.15654991
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.12614567
64EWS_26573619_Chip-Seq_HEK293_Human1.12543512
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.12080732
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12080732
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11836619
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11540883
69STAT3_18555785_Chip-Seq_ESCs_Mouse1.11244475
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.10499542
71PHF8_20622853_ChIP-Seq_HELA_Human1.09100697
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.08615702
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06766740
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.06259341
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06162559
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05403122
77OCT4_18555785_Chip-Seq_ESCs_Mouse1.05099353
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05064630
79P300_18555785_Chip-Seq_ESCs_Mouse1.04268439
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04156196
81* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02465068
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02253490
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02253490
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01588267
85NFYA_21822215_ChIP-Seq_K562_Human1.01471374
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01106612
87ETV1_20927104_ChIP-Seq_GIST48_Human1.00355367
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00133019
89HNFA_21074721_ChIP-Seq_CACO-2_Human0.99438664
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99329048
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96179560
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94800036
93GATA4_25053715_ChIP-Seq_YYC3_Human0.94722562
94SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92260439
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89358732
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85205398
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85205394
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83013054
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75689835
100RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74885436
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74806071
102ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71993743
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71233195
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.70527550
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70313408
106* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.69437566
107RARA_24833708_ChIP-Seq_LIVER_Mouse0.69359804
108NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69357883
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69357883
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68959817
111AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66921367
112STAT1_17558387_ChIP-Seq_HELA_Human0.66472748
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66065302
114TAF15_26573619_Chip-Seq_HEK293_Human0.65393057
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64901310
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64066320
117AR_20517297_ChIP-Seq_VCAP_Human0.63964747
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.63308214
119EGR1_19032775_ChIP-ChIP_M12_Human0.62785686
120ESR1_21235772_ChIP-Seq_MCF-7_Human0.62621649
121CEBPB_22108803_ChIP-Seq_LS180_Human0.61611112
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61000165
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.60534597
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.59280746
125RARB_24833708_ChIP-Seq_LIVER_Mouse0.58144722
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.57848096
127SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.57702812
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57412868
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56618094
130ESET_19884257_ChIP-Seq_ESCs_Mouse0.56451739
131MYC_19915707_ChIP-ChIP_AK7_Human0.54286483
132CBP_21632823_ChIP-Seq_H3396_Human0.53772462
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.53604455
134EZH2_27294783_Chip-Seq_NPCs_Mouse0.52608890
135* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.52005581
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.51478889
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.50792869
138NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.50446475
139SUZ12_27294783_Chip-Seq_NPCs_Mouse0.50171753
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.49338390
141IRF1_19129219_ChIP-ChIP_H3396_Human0.48458119
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48306043
143* CRX_20693478_ChIP-Seq_RETINA_Mouse0.48253328
144CDX2_22108803_ChIP-Seq_LS180_Human0.46694607
145* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.45917655
146RUNX1_27457419_Chip-Seq_LIVER_Mouse0.45297083
147BCAT_22108803_ChIP-Seq_LS180_Human0.44599044
148TAF2_19829295_ChIP-Seq_ESCs_Human0.44584298
149GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.44202801
150P53_21459846_ChIP-Seq_SAOS-2_Human0.43858109
151FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43357391
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.42448764
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42204927
154NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.41442153
155FOXH1_21741376_ChIP-Seq_EPCs_Human0.41354689
156SOX2_20726797_ChIP-Seq_SW620_Human0.40697754
157PPAR_26484153_Chip-Seq_NCI-H1993_Human0.40579444
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.40577452
159GATA6_25053715_ChIP-Seq_YYC3_Human0.39086582
160ERG_20517297_ChIP-Seq_VCAP_Human0.38338100
161AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.38013142
162GATA1_19941827_ChIP-Seq_MEL_Mouse0.37419631
163GATA2_19941826_ChIP-Seq_K562_Human0.36739908
164NCOR_22424771_ChIP-Seq_293T_Human0.36595095

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.39081680
2MP0005360_urolithiasis7.69079154
3MP0005085_abnormal_gallbladder_physiolo6.22642790
4MP0005365_abnormal_bile_salt6.03805863
5MP0008875_abnormal_xenobiotic_pharmacok5.28569277
6MP0003806_abnormal_nucleotide_metabolis3.99694429
7MP0003252_abnormal_bile_duct3.95364666
8MP0010329_abnormal_lipoprotein_level3.35982133
9MP0003195_calcinosis3.13059631
10MP0005332_abnormal_amino_acid3.11321227
11MP0009840_abnormal_foam_cell2.91893452
12MP0005083_abnormal_biliary_tract2.80292448
13MP0004019_abnormal_vitamin_homeostasis2.69079891
14MP0001666_abnormal_nutrient_absorption2.50107094
15MP0002138_abnormal_hepatobiliary_system2.40359240
16MP0003191_abnormal_cellular_cholesterol2.11009911
17MP0000609_abnormal_liver_physiology2.04121404
18MP0002118_abnormal_lipid_homeostasis2.02963572
19MP0005451_abnormal_body_composition1.87586056
20MP0005319_abnormal_enzyme/_coenzyme1.81835053
21MP0001764_abnormal_homeostasis1.77868657
22MP0003868_abnormal_feces_composition1.77189766
23MP0005584_abnormal_enzyme/coenzyme_acti1.59176051
24MP0009643_abnormal_urine_homeostasis1.57758133
25MP0009697_abnormal_copulation1.54877721
26MP0003186_abnormal_redox_activity1.45698121
27MP0005551_abnormal_eye_electrophysiolog1.39386220
28MP0003011_delayed_dark_adaptation1.26600345
29MP0005636_abnormal_mineral_homeostasis1.20343486
30MP0009764_decreased_sensitivity_to1.19215877
31MP0005187_abnormal_penis_morphology1.18648518
32MP0002876_abnormal_thyroid_physiology1.12001717
33MP0005647_abnormal_sex_gland1.10849228
34MP0000598_abnormal_liver_morphology1.10044162
35MP0001501_abnormal_sleep_pattern1.06030898
36MP0003656_abnormal_erythrocyte_physiolo1.05399722
37MP0003646_muscle_fatigue1.02617944
38MP0005646_abnormal_pituitary_gland1.02159043
39MP0001986_abnormal_taste_sensitivity1.00288692
40MP0010386_abnormal_urinary_bladder0.99601971
41MP0001968_abnormal_touch/_nociception0.98842296
42MP0009763_increased_sensitivity_to0.95764065
43MP0005408_hypopigmentation0.95331354
44MP0005084_abnormal_gallbladder_morpholo0.94574288
45MP0001756_abnormal_urination0.93271388
46MP0005670_abnormal_white_adipose0.92620386
47MP0008469_abnormal_protein_level0.90619009
48MP0006036_abnormal_mitochondrial_physio0.90232673
49MP0009642_abnormal_blood_homeostasis0.89262380
50MP0002254_reproductive_system_inflammat0.88857552
51MP0000569_abnormal_digit_pigmentation0.86948828
52MP0000604_amyloidosis0.85856549
53MP0004043_abnormal_pH_regulation0.85036016
54MP0002102_abnormal_ear_morphology0.83123178
55MP0009765_abnormal_xenobiotic_induced0.81860770
56MP0009745_abnormal_behavioral_response0.79868654
57MP0002136_abnormal_kidney_physiology0.78914821
58MP0002736_abnormal_nociception_after0.78796803
59MP0005645_abnormal_hypothalamus_physiol0.76315478
60MP0004142_abnormal_muscle_tone0.75568062
61MP0002078_abnormal_glucose_homeostasis0.75555429
62MP0005376_homeostasis/metabolism_phenot0.75240620
63MP0002282_abnormal_trachea_morphology0.72947318
64MP0005535_abnormal_body_temperature0.71358660
65MP0003879_abnormal_hair_cell0.70545219
66MP0001984_abnormal_olfaction0.69769347
67MP0002090_abnormal_vision0.69132230
68MP0005220_abnormal_exocrine_pancreas0.69064336
69MP0005334_abnormal_fat_pad0.67218739
70MP0000427_abnormal_hair_cycle0.66608127
71MP0006276_abnormal_autonomic_nervous0.65531144
72MP0005253_abnormal_eye_physiology0.65418219
73MP0010368_abnormal_lymphatic_system0.64542717
74MP0002971_abnormal_brown_adipose0.64317156
75MP0009046_muscle_twitch0.63794203
76MP0008877_abnormal_DNA_methylation0.63719357
77MP0000372_irregular_coat_pigmentation0.63108565
78MP0003705_abnormal_hypodermis_morpholog0.62683669
79MP0001661_extended_life_span0.62567629
80MP0005167_abnormal_blood-brain_barrier0.62475031
81MP0006035_abnormal_mitochondrial_morpho0.62196172
82MP0006292_abnormal_olfactory_placode0.61385846
83MP0002638_abnormal_pupillary_reflex0.60601477
84MP0002928_abnormal_bile_duct0.59076724
85MP0005395_other_phenotype0.58295656
86MP0003724_increased_susceptibility_to0.58295542
87MP0005410_abnormal_fertilization0.57748949
88MP0005266_abnormal_metabolism0.57712837
89MP0003718_maternal_effect0.55425825
90MP0001765_abnormal_ion_homeostasis0.55144672
91MP0004782_abnormal_surfactant_physiolog0.54443703
92MP0002272_abnormal_nervous_system0.53336660
93MP0004924_abnormal_behavior0.51845784
94MP0005386_behavior/neurological_phenoty0.51845784
95MP0003690_abnormal_glial_cell0.51744173
96MP0001486_abnormal_startle_reflex0.50714311
97MP0001485_abnormal_pinna_reflex0.50380539
98MP0003638_abnormal_response/metabolism_0.50344564
99MP0003950_abnormal_plasma_membrane0.50178349
100MP0009053_abnormal_anal_canal0.49723295
101MP0005448_abnormal_energy_balance0.49283861
102MP0004130_abnormal_muscle_cell0.46954903
103MP0003045_fibrosis0.46477909
104MP0005464_abnormal_platelet_physiology0.46039962
105MP0000639_abnormal_adrenal_gland0.45629932
106MP0002168_other_aberrant_phenotype0.45568843
107MP0002332_abnormal_exercise_endurance0.45163224
108MP0002653_abnormal_ependyma_morphology0.44867750
109MP0003633_abnormal_nervous_system0.44560463
110MP0003953_abnormal_hormone_level0.44079620
111MP0000230_abnormal_systemic_arterial0.44050410
112MP0004381_abnormal_hair_follicle0.43940745
113MP0003436_decreased_susceptibility_to0.43879334
114MP0003880_abnormal_central_pattern0.42605637
115MP0001324_abnormal_eye_pigmentation0.42489399
116MP0002938_white_spotting0.42086657
117MP0008874_decreased_physiological_sensi0.42042598
118MP0008872_abnormal_physiological_respon0.41908599
119MP0003329_amyloid_beta_deposits0.41582994
120MP0000538_abnormal_urinary_bladder0.39825659
121MP0008873_increased_physiological_sensi0.38079155
122MP0002822_catalepsy0.35986012
123MP0006082_CNS_inflammation0.35354838
124MP0005666_abnormal_adipose_tissue0.34612603
125MP0001845_abnormal_inflammatory_respons0.34210680
126MP0001853_heart_inflammation0.34055601
127MP0009115_abnormal_fat_cell0.32106314
128MP0002135_abnormal_kidney_morphology0.30891309
129MP0005248_abnormal_Harderian_gland0.30602997
130MP0002132_abnormal_respiratory_system0.29892774
131MP0005166_decreased_susceptibility_to0.29180451
132MP0002796_impaired_skin_barrier0.28601451
133MP0003075_altered_response_to0.28106744
134MP0005058_abnormal_lysosome_morphology0.28040474
135MP0009672_abnormal_birth_weight0.27199441
136MP0002837_dystrophic_cardiac_calcinosis0.24275811
137MP0000249_abnormal_blood_vessel0.23441840
138MP0002970_abnormal_white_adipose0.23408773
139MP0004264_abnormal_extraembryonic_tissu0.22743949
140MP0001243_abnormal_dermal_layer0.21453218
141MP0000579_abnormal_nail_morphology0.21427174

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.19235689
2Intrahepatic cholestasis (HP:0001406)6.79273801
3Deep venous thrombosis (HP:0002625)6.54997395
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.31582462
5Hypobetalipoproteinemia (HP:0003563)6.03661305
6Prolonged partial thromboplastin time (HP:0003645)5.97971309
7Xanthomatosis (HP:0000991)5.88244730
8Hyperlipoproteinemia (HP:0010980)5.09996780
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.67029699
10Hyperammonemia (HP:0001987)4.62781569
11Hyperglycinemia (HP:0002154)4.56323150
12Hyperglycinuria (HP:0003108)4.55578726
13Joint hemorrhage (HP:0005261)4.53715097
14Ketosis (HP:0001946)4.44434527
15Hypolipoproteinemia (HP:0010981)4.40360362
16Abnormality of aspartate family amino acid metabolism (HP:0010899)4.39334312
17Abnormality of serine family amino acid metabolism (HP:0010894)4.32294241
18Abnormality of glycine metabolism (HP:0010895)4.32294241
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.26823994
20Complement deficiency (HP:0004431)4.26482866
21Epidermoid cyst (HP:0200040)4.22253211
22Abnormality of methionine metabolism (HP:0010901)4.11805750
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.02470052
24Fat malabsorption (HP:0002630)3.90407715
25Abnormality of the common coagulation pathway (HP:0010990)3.87361270
26Hypoglycemic coma (HP:0001325)3.85129264
27Abnormality of pyrimidine metabolism (HP:0004353)3.84230189
28Hypoalphalipoproteinemia (HP:0003233)3.77079292
29Conjugated hyperbilirubinemia (HP:0002908)3.76224520
30Abnormality of fatty-acid metabolism (HP:0004359)3.74128330
31Fair hair (HP:0002286)3.64579278
32Abnormality of nucleobase metabolism (HP:0010932)3.45020010
33Ketoacidosis (HP:0001993)3.40075401
34Delayed CNS myelination (HP:0002188)3.38450633
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37493387
36Hypercholesterolemia (HP:0003124)3.36862887
37Abnormality of the intrinsic pathway (HP:0010989)3.33966466
38Hyperbilirubinemia (HP:0002904)3.29133423
39Gout (HP:0001997)3.28896533
40Abnormality of purine metabolism (HP:0004352)3.25414921
41Abnormality of serum amino acid levels (HP:0003112)3.19743082
42Abnormal biliary tract physiology (HP:0012439)3.09844890
43Bile duct proliferation (HP:0001408)3.09844890
44Hyperventilation (HP:0002883)3.09094191
45Metabolic acidosis (HP:0001942)3.06619430
46Abnormality of complement system (HP:0005339)3.06179703
47Vascular calcification (HP:0004934)2.98509568
48Steatorrhea (HP:0002570)2.93653212
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.90474119
50Dicarboxylic aciduria (HP:0003215)2.90474119
51Lethargy (HP:0001254)2.84380577
52Hepatocellular carcinoma (HP:0001402)2.83475525
53Reduced antithrombin III activity (HP:0001976)2.82166645
54Proximal tubulopathy (HP:0000114)2.81523174
55Nephritis (HP:0000123)2.74420822
56Generalized aminoaciduria (HP:0002909)2.73510846
57Generalized hypopigmentation of hair (HP:0011358)2.68979402
58Alkalosis (HP:0001948)2.63879947
59Myocardial infarction (HP:0001658)2.62145075
60Cardiovascular calcification (HP:0011915)2.61975582
61Spontaneous abortion (HP:0005268)2.51927418
62Pancreatic cysts (HP:0001737)2.51813034
63Hypochromic microcytic anemia (HP:0004840)2.49671366
64Cerebral edema (HP:0002181)2.49450717
65Malnutrition (HP:0004395)2.47001793
66Skin nodule (HP:0200036)2.46870564
67Hypoglycemic seizures (HP:0002173)2.46407746
68Irritability (HP:0000737)2.46254532
69Increased purine levels (HP:0004368)2.43940363
70Hyperuricemia (HP:0002149)2.43940363
71Enlarged kidneys (HP:0000105)2.42913049
72Abnormality of urine glucose concentration (HP:0011016)2.37384978
73Glycosuria (HP:0003076)2.37384978
74Systemic lupus erythematosus (HP:0002725)2.37083363
75Chronic hepatic failure (HP:0100626)2.36429794
76Abnormality of the renal cortex (HP:0011035)2.34451315
77Vomiting (HP:0002013)2.34424304
78Rickets (HP:0002748)2.32817306
79Spastic diplegia (HP:0001264)2.32691221
80Hydroxyprolinuria (HP:0003080)2.30917032
81Abnormality of proline metabolism (HP:0010907)2.30917032
82Mitral stenosis (HP:0001718)2.30163591
83Acanthocytosis (HP:0001927)2.29216607
84Renal cortical cysts (HP:0000803)2.27417784
85Neonatal onset (HP:0003623)2.24627244
86Pancreatitis (HP:0001733)2.20918858
87Glomerulonephritis (HP:0000099)2.20737985
88Abnormal gallbladder morphology (HP:0012437)2.18285872
89Arthropathy (HP:0003040)2.17831753
90Hypothermia (HP:0002045)2.15295038
91Late onset (HP:0003584)2.14604093
92Sensorimotor neuropathy (HP:0007141)2.13517292
93Congenital stationary night blindness (HP:0007642)2.12554956
94Cholecystitis (HP:0001082)2.11217857
95Abnormal gallbladder physiology (HP:0012438)2.11217857
96Brushfield spots (HP:0001088)2.11216905
97Opisthotonus (HP:0002179)2.11074512
98Cholelithiasis (HP:0001081)2.09253508
99Pancreatic fibrosis (HP:0100732)2.06863210
100Pulmonary embolism (HP:0002204)2.05627442
101Esophageal varix (HP:0002040)2.04531233
102Hypophosphatemic rickets (HP:0004912)2.03378561
103True hermaphroditism (HP:0010459)2.02490060
104Menorrhagia (HP:0000132)2.01414464
105Abnormal enzyme/coenzyme activity (HP:0012379)1.99709023
106Attenuation of retinal blood vessels (HP:0007843)1.96698502
107Gaze-evoked nystagmus (HP:0000640)1.96482812
108Abnormality of alanine metabolism (HP:0010916)1.95839874
109Hyperalaninemia (HP:0003348)1.95839874
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95839874
111Hyperinsulinemic hypoglycemia (HP:0000825)1.93353077
112Blue irides (HP:0000635)1.92577531
113Osteomalacia (HP:0002749)1.90549160
114Gingival bleeding (HP:0000225)1.89500768
115Thrombophlebitis (HP:0004418)1.89131171
116Recurrent gram-negative bacterial infections (HP:0005420)1.88074582
117Amyloidosis (HP:0011034)1.87720950
118Elevated hepatic transaminases (HP:0002910)1.87370842
119Nausea (HP:0002018)1.86939024
120Abnormality of vitamin metabolism (HP:0100508)1.85082502
121Abnormality of the gallbladder (HP:0005264)1.82913576
122Abolished electroretinogram (ERG) (HP:0000550)1.82776381
123Abnormal cartilage morphology (HP:0002763)1.80290049
124Poikilocytosis (HP:0004447)1.79078411
125Abnormality of midbrain morphology (HP:0002418)1.76801112
126Molar tooth sign on MRI (HP:0002419)1.76801112
127Neonatal hypoglycemia (HP:0001998)1.74942207
128Hyperphosphaturia (HP:0003109)1.72160581
129Nephronophthisis (HP:0000090)1.69530510
130Decreased central vision (HP:0007663)1.67766781
131Cerebral palsy (HP:0100021)1.66500784
132Tubulointerstitial nephritis (HP:0001970)1.65825446
133Facial shape deformation (HP:0011334)1.65524285
134Potter facies (HP:0002009)1.65524285
135Abnormality of the renal medulla (HP:0100957)1.64455775
136Abnormality of transition element cation homeostasis (HP:0011030)1.63829314
137Congenital hepatic fibrosis (HP:0002612)1.62530850
138Inability to walk (HP:0002540)1.60306235
139Cystic liver disease (HP:0006706)1.57803145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.27713529
2FGFR44.00925059
3SIK13.90361845
4INSRR3.44705380
5ERN13.26131739
6MAP4K22.90512338
7ADRBK22.89636503
8TAOK32.64737966
9BMPR1B2.58999974
10ERBB42.46418421
11MST1R2.27449645
12WNK32.27183670
13PIK3CG2.11301125
14STK38L2.07393486
15ACVR1B2.06034477
16FLT31.98346683
17ZAK1.94971442
18MAP2K41.94721327
19IRAK31.93800089
20CASK1.85649610
21MAP3K141.85257139
22MAPK111.71788868
23OXSR11.71327142
24MAPK131.70030419
25WNK41.65280781
26MAP3K41.60218332
27ABL21.52030301
28NTRK31.50823393
29TYK21.49016346
30PINK11.45995002
31PKN21.45665185
32FRK1.42660702
33NEK91.39210376
34LATS11.38999039
35KDR1.35786785
36TNK21.33131656
37PRKAA21.22335146
38STK391.19988008
39PAK31.18332679
40TIE11.16859926
41SGK21.15391174
42PRKCE1.10992428
43DAPK21.09363679
44ADRBK11.06691754
45EIF2AK31.06575594
46TXK1.05156642
47SGK31.02720600
48MAP3K71.00819680
49TBK11.00604193
50FER1.00050742
51TRIM280.99375374
52JAK20.99004453
53SGK4940.98776684
54SGK2230.98776684
55TNIK0.98522889
56MAPK40.97912170
57PTK60.97865495
58MKNK20.95958411
59MAP3K30.92038666
60IRAK10.91698112
61PRKCZ0.90655547
62BCR0.89706956
63IRAK20.89439040
64JAK10.89202868
65MAPK150.89020459
66GRK60.88601207
67NLK0.87259378
68PTK2B0.86485629
69EPHA30.84130881
70MAP2K30.83503002
71TEC0.83373458
72MUSK0.82620692
73FGFR20.80532668
74MAP2K60.77347006
75GRK10.76421874
76CSNK1A1L0.76136382
77IKBKE0.75460474
78PBK0.73202003
79AKT30.71659739
80PRKAA10.71366540
81ERBB20.70989090
82PRKACG0.70443029
83CSNK1G20.70396154
84GSK3A0.70196944
85TGFBR20.70056631
86TLK10.69655816
87CSNK1G30.68669006
88PRKACA0.67022859
89CAMKK20.66230940
90PDK30.66159404
91PDK40.66159404
92DYRK1B0.66046607
93ERBB30.65630027
94MAPK120.65476790
95CSK0.64668491
96MARK10.64450399
97MAPKAPK30.63857051
98CSNK1D0.63133255
99PLK20.62147496
100MAPK70.62097239
101PRKG10.61753147
102MAP3K110.61540200
103CAMK2G0.59000610
104STK160.56343712
105OBSCN0.55742960
106IRAK40.55633015
107MET0.54465139
108CSNK1A10.53296422
109CDK60.52555846
110CAMK2A0.51526057
111STK30.50572121
112TGFBR10.49422759
113PRKCQ0.49321977
114PDK20.48557993
115CAMK1D0.46868621
116BRSK20.46708949
117PRKCB0.46210166
118GRK70.45942088
119TRPM70.45295387
120PRKACB0.44956788
121MAP3K130.44297155
122CSNK1G10.43438460
123BLK0.43271536
124MAP2K70.42181809
125MAP3K100.41765596
126FGFR30.41449659
127DYRK20.41094091
128IGF1R0.40682553
129CSF1R0.39722338
130TAOK20.38868263
131EPHB10.37572788
132PRKCG0.36939779
133PTK20.36769149
134PDPK10.36396674
135GRK50.36282555
136MST40.36274077
137ITK0.34103326
138CHUK0.34046906
139DYRK1A0.33999726
140PKN10.33369560
141PRKCA0.32536401
142PLK40.32123693
143CAMK40.31332427
144PHKG10.30784454
145PHKG20.30784454
146MAP3K50.30002814
147EPHA40.29896306
148KIT0.29734409
149IKBKB0.26729317
150MYLK0.25887435
151PIK3CA0.25798509
152STK380.24952537
153CDK40.24741778
154EIF2AK20.24300333
155ABL10.23775462
156NUAK10.22788993
157MAP3K60.22248965

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.14302854
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.56758749
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.11634556
4Nitrogen metabolism_Homo sapiens_hsa009103.09807691
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.87592460
6Arginine biosynthesis_Homo sapiens_hsa002202.80475467
7Tryptophan metabolism_Homo sapiens_hsa003802.75967615
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66034348
9Fatty acid degradation_Homo sapiens_hsa000712.56768095
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55475236
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51665147
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45562987
13Butanoate metabolism_Homo sapiens_hsa006502.35753829
14Complement and coagulation cascades_Homo sapiens_hsa046102.33852716
15Peroxisome_Homo sapiens_hsa041462.24033940
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18637950
17Propanoate metabolism_Homo sapiens_hsa006402.15344422
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.97155490
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97043256
20Chemical carcinogenesis_Homo sapiens_hsa052041.96816203
21Histidine metabolism_Homo sapiens_hsa003401.92064819
22Fatty acid metabolism_Homo sapiens_hsa012121.89997122
23beta-Alanine metabolism_Homo sapiens_hsa004101.88559866
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87936894
25PPAR signaling pathway_Homo sapiens_hsa033201.85905614
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.82691054
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.77448086
28* Retinol metabolism_Homo sapiens_hsa008301.63669869
29Caffeine metabolism_Homo sapiens_hsa002321.60702480
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59918431
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57312759
32Phenylalanine metabolism_Homo sapiens_hsa003601.54082428
33Selenocompound metabolism_Homo sapiens_hsa004501.52593078
34Staphylococcus aureus infection_Homo sapiens_hsa051501.52560028
35Pyruvate metabolism_Homo sapiens_hsa006201.52080667
36Bile secretion_Homo sapiens_hsa049761.49195921
37Fatty acid elongation_Homo sapiens_hsa000621.45992704
38Sulfur metabolism_Homo sapiens_hsa009201.43267971
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39495781
40Tyrosine metabolism_Homo sapiens_hsa003501.36285475
41Starch and sucrose metabolism_Homo sapiens_hsa005001.34047885
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.28355192
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.24620910
44Folate biosynthesis_Homo sapiens_hsa007901.23399569
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21905408
46Steroid biosynthesis_Homo sapiens_hsa001001.18787194
47ABC transporters_Homo sapiens_hsa020101.17961192
48Carbon metabolism_Homo sapiens_hsa012001.15733190
49Biosynthesis of amino acids_Homo sapiens_hsa012301.11775080
50Vitamin digestion and absorption_Homo sapiens_hsa049771.09682786
51Arginine and proline metabolism_Homo sapiens_hsa003301.05161446
52Fat digestion and absorption_Homo sapiens_hsa049751.03783986
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02011910
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.01756939
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01152755
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96267741
57Lysine degradation_Homo sapiens_hsa003100.88762509
58Sulfur relay system_Homo sapiens_hsa041220.85228733
59Glutathione metabolism_Homo sapiens_hsa004800.79814255
60Vitamin B6 metabolism_Homo sapiens_hsa007500.77396672
61One carbon pool by folate_Homo sapiens_hsa006700.74736962
62Glycerolipid metabolism_Homo sapiens_hsa005610.73793848
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73072941
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60784270
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58452809
66Pentose phosphate pathway_Homo sapiens_hsa000300.56671191
67* Metabolic pathways_Homo sapiens_hsa011000.51456564
68Fatty acid biosynthesis_Homo sapiens_hsa000610.47656068
69Phototransduction_Homo sapiens_hsa047440.46497850
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34597396
71Serotonergic synapse_Homo sapiens_hsa047260.33766914
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32838730
73Fructose and mannose metabolism_Homo sapiens_hsa000510.31742969
74Ether lipid metabolism_Homo sapiens_hsa005650.30518422
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29420134
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26024836
77Galactose metabolism_Homo sapiens_hsa000520.25877373
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21459452
79Linoleic acid metabolism_Homo sapiens_hsa005910.20117235
80Nicotine addiction_Homo sapiens_hsa050330.17673875
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.14463372
82Insulin resistance_Homo sapiens_hsa049310.14253807
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.11879144
84Sphingolipid metabolism_Homo sapiens_hsa006000.10148232
85Protein export_Homo sapiens_hsa030600.09659232
86Pertussis_Homo sapiens_hsa051330.08857707
87Prion diseases_Homo sapiens_hsa050200.08644669
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06905360
89Taste transduction_Homo sapiens_hsa047420.06357710
90GABAergic synapse_Homo sapiens_hsa047270.06101641
91Systemic lupus erythematosus_Homo sapiens_hsa053220.03989100
92Glucagon signaling pathway_Homo sapiens_hsa049220.02368107
93Circadian rhythm_Homo sapiens_hsa047100.01938114
94Olfactory transduction_Homo sapiens_hsa047400.01474091
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00889772
96Pyrimidine metabolism_Homo sapiens_hsa00240-0.2477982
97Lysosome_Homo sapiens_hsa04142-0.2416962
98Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.2265905
99Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2070302
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2053517
101Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1999487
102Protein digestion and absorption_Homo sapiens_hsa04974-0.1876071
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1857235
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1856183
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1762657
106Other glycan degradation_Homo sapiens_hsa00511-0.1761972
107African trypanosomiasis_Homo sapiens_hsa05143-0.1748664
108Hepatitis C_Homo sapiens_hsa05160-0.1667057
109Mineral absorption_Homo sapiens_hsa04978-0.1365013
110Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1049352
111Renin-angiotensin system_Homo sapiens_hsa04614-0.0878773
112Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0780158
113Glutamatergic synapse_Homo sapiens_hsa04724-0.0549969
114AMPK signaling pathway_Homo sapiens_hsa04152-0.0492708
115Morphine addiction_Homo sapiens_hsa05032-0.0433953
116Regulation of autophagy_Homo sapiens_hsa04140-0.0361515
117Fanconi anemia pathway_Homo sapiens_hsa03460-0.0330298
118Homologous recombination_Homo sapiens_hsa03440-0.0257127
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0185084
120Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0167031
121Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0143272
122Insulin secretion_Homo sapiens_hsa04911-0.0114144

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