RDH5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments. Mutations in this gene cause autosomal recessive fundus albipunctatus, a rare form of night blindness that is characterized by a delay in the regeneration of cone and rod photopigments. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S1 (biogenesis of lysosomal organelles complex-1, subunit 1) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)6.57824828
2triglyceride catabolic process (GO:0019433)6.19869898
3low-density lipoprotein particle clearance (GO:0034383)6.01770076
4acylglycerol catabolic process (GO:0046464)5.58050314
5neutral lipid catabolic process (GO:0046461)5.58050314
6L-phenylalanine metabolic process (GO:0006558)5.30638101
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.30638101
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.14903262
9regulation of cholesterol esterification (GO:0010872)5.11359392
10L-phenylalanine catabolic process (GO:0006559)5.01458921
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.01458921
12low-density lipoprotein particle remodeling (GO:0034374)4.67326498
13aromatic amino acid family catabolic process (GO:0009074)4.54319093
14diacylglycerol metabolic process (GO:0046339)4.42938780
15glycerolipid catabolic process (GO:0046503)4.38384495
16high-density lipoprotein particle remodeling (GO:0034375)4.28172695
17reverse cholesterol transport (GO:0043691)4.27645112
18tryptophan catabolic process (GO:0006569)4.20043360
19indole-containing compound catabolic process (GO:0042436)4.20043360
20indolalkylamine catabolic process (GO:0046218)4.20043360
21brown fat cell differentiation (GO:0050873)4.19401810
22aldehyde catabolic process (GO:0046185)4.16901619
23tryptophan metabolic process (GO:0006568)4.10424533
24exogenous drug catabolic process (GO:0042738)4.04457875
25glyoxylate metabolic process (GO:0046487)4.03779532
26kynurenine metabolic process (GO:0070189)4.03539123
27plasma lipoprotein particle remodeling (GO:0034369)4.03356975
28protein-lipid complex remodeling (GO:0034368)4.03356975
29macromolecular complex remodeling (GO:0034367)4.03356975
30fatty acid homeostasis (GO:0055089)3.93079186
31amino-acid betaine metabolic process (GO:0006577)3.91456413
32drug catabolic process (GO:0042737)3.89518135
33tyrosine metabolic process (GO:0006570)3.87554496
34fatty acid transmembrane transport (GO:1902001)3.85712563
35bile acid biosynthetic process (GO:0006699)3.85644996
36glycine metabolic process (GO:0006544)3.82974169
37serine family amino acid catabolic process (GO:0009071)3.81750135
38aromatic amino acid family metabolic process (GO:0009072)3.74248003
39cysteine metabolic process (GO:0006534)3.71375241
40triglyceride homeostasis (GO:0070328)3.70408601
41acylglycerol homeostasis (GO:0055090)3.70408601
42ethanol oxidation (GO:0006069)3.70102707
43behavioral response to nicotine (GO:0035095)3.67151670
44regulation of triglyceride catabolic process (GO:0010896)3.61183902
45response to dietary excess (GO:0002021)3.60629765
46amine catabolic process (GO:0009310)3.59288681
47cellular biogenic amine catabolic process (GO:0042402)3.59288681
48ribosomal small subunit assembly (GO:0000028)3.57449073
49ethanol metabolic process (GO:0006067)3.55745858
50glycerol metabolic process (GO:0006071)3.53663036
51cellular glucuronidation (GO:0052695)3.53498204
52lipid particle organization (GO:0034389)3.53193264
53carnitine metabolic process (GO:0009437)3.52065179
54lipid storage (GO:0019915)3.51800830
55omega-hydroxylase P450 pathway (GO:0097267)3.49617428
56regulation of fibrinolysis (GO:0051917)3.49216174
57viral transcription (GO:0019083)3.48414837
58L-methionine salvage (GO:0071267)3.42556295
59L-methionine biosynthetic process (GO:0071265)3.42556295
60amino acid salvage (GO:0043102)3.42556295
61vitamin A metabolic process (GO:0006776)3.41967078
62response to nitrosative stress (GO:0051409)3.41630866
63sulfur amino acid catabolic process (GO:0000098)3.41523893
64negative regulation of fibrinolysis (GO:0051918)3.38608850
65triglyceride biosynthetic process (GO:0019432)3.38272194
66acylglycerol biosynthetic process (GO:0046463)3.37988683
67neutral lipid biosynthetic process (GO:0046460)3.37988683
68phospholipid efflux (GO:0033700)3.37931219
69valine metabolic process (GO:0006573)3.36837813
70white fat cell differentiation (GO:0050872)3.34187159
71serine family amino acid metabolic process (GO:0009069)3.34085957
72alpha-amino acid catabolic process (GO:1901606)3.32826595
73DNA deamination (GO:0045006)3.31609656
74translational termination (GO:0006415)3.31522131
75chaperone-mediated protein transport (GO:0072321)3.29444584
76glucuronate metabolic process (GO:0019585)3.28406673
77uronic acid metabolic process (GO:0006063)3.28406673
78short-chain fatty acid metabolic process (GO:0046459)3.27709831
79alpha-linolenic acid metabolic process (GO:0036109)3.27305936
80negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.26297458
81fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.25816593
82serine family amino acid biosynthetic process (GO:0009070)3.24941906
83regulation of lipoprotein metabolic process (GO:0050746)3.24713911
84sodium-independent organic anion transport (GO:0043252)3.24631166
85L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.23217931
86negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.22403664
87response to phenylpropanoid (GO:0080184)3.21488561
88regulation of glycogen (starch) synthase activity (GO:2000465)3.21202619
89positive regulation of lipid storage (GO:0010884)3.19838443
90transcytosis (GO:0045056)3.19396242
91homocysteine metabolic process (GO:0050667)3.18249205
92S-adenosylmethionine metabolic process (GO:0046500)3.13569774
93regulation of triglyceride metabolic process (GO:0090207)3.12827701
94alditol metabolic process (GO:0019400)3.12576725
95bile acid metabolic process (GO:0008206)3.12453249
96positive regulation of respiratory burst (GO:0060267)3.11351641
97cellular amino acid catabolic process (GO:0009063)3.11296621
98cholesterol catabolic process (GO:0006707)3.10609665
99sterol catabolic process (GO:0016127)3.10609665
100positive regulation of fatty acid oxidation (GO:0046321)3.09686808
101purine ribonucleotide transport (GO:0015868)3.09593579
102regulation of triglyceride biosynthetic process (GO:0010866)3.09497527
103mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09339558
104urea cycle (GO:0000050)3.08895542
105urea metabolic process (GO:0019627)3.08895542
106fatty acid catabolic process (GO:0009062)3.08464499
107regulation of protein activation cascade (GO:2000257)3.08345577
108plasma lipoprotein particle organization (GO:0071827)3.08119673
109phosphatidic acid biosynthetic process (GO:0006654)3.07692652
110phosphatidic acid metabolic process (GO:0046473)3.07692652
111positive regulation of glycolytic process (GO:0045821)3.07137342
112phospholipid homeostasis (GO:0055091)3.06221839
113primary alcohol catabolic process (GO:0034310)3.05867574
114triglyceride metabolic process (GO:0006641)3.05674149
115cotranslational protein targeting to membrane (GO:0006613)3.03253945
116blood coagulation, intrinsic pathway (GO:0007597)3.03117496
117fatty acid beta-oxidation (GO:0006635)3.02895347
118biotin metabolic process (GO:0006768)3.02310648
119SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.02275869
120plasma lipoprotein particle assembly (GO:0034377)3.01379970
121cellular ketone body metabolic process (GO:0046950)3.00217653
122arginine metabolic process (GO:0006525)3.00140030
123indolalkylamine metabolic process (GO:0006586)2.99603908
124negative regulation of response to food (GO:0032096)2.98883108
125negative regulation of appetite (GO:0032099)2.98883108
126arginine catabolic process (GO:0006527)2.97098052
127epoxygenase P450 pathway (GO:0019373)2.96587074
128* retinol metabolic process (GO:0042572)2.96209092
129monocarboxylic acid catabolic process (GO:0072329)2.95570973
130spliceosomal tri-snRNP complex assembly (GO:0000244)2.95174630
131negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.95172257
132protein targeting to ER (GO:0045047)2.94756174
133oxidative demethylation (GO:0070989)2.93691953
134positive regulation of triglyceride lipase activity (GO:0061365)2.93207482
135positive regulation of lipoprotein lipase activity (GO:0051006)2.93207482
136gap junction assembly (GO:0016264)2.92667102
137* primary alcohol metabolic process (GO:0034308)2.92007670
138positive regulation of fatty acid metabolic process (GO:0045923)2.91726719
139branched-chain amino acid catabolic process (GO:0009083)2.90735760
140lysine catabolic process (GO:0006554)2.90674653
141lysine metabolic process (GO:0006553)2.90674653
142plasma lipoprotein particle clearance (GO:0034381)2.90669233
143ketone body metabolic process (GO:1902224)2.89854172
144positive regulation of triglyceride metabolic process (GO:0090208)2.89144567
145detection of light stimulus involved in sensory perception (GO:0050962)2.88865930
146detection of light stimulus involved in visual perception (GO:0050908)2.88865930
147cofactor catabolic process (GO:0051187)2.88364937
148negative regulation of protein autophosphorylation (GO:0031953)2.88357043
149negative regulation of cholesterol transport (GO:0032375)2.87991615
150negative regulation of sterol transport (GO:0032372)2.87991615
151cholesterol efflux (GO:0033344)2.87403872
152organic acid catabolic process (GO:0016054)2.87118839
153carboxylic acid catabolic process (GO:0046395)2.87118839
154positive regulation of fatty acid beta-oxidation (GO:0032000)2.87046726
155protein-lipid complex subunit organization (GO:0071825)2.86370736
156acylglycerol metabolic process (GO:0006639)2.86052470
157regulation of cholesterol metabolic process (GO:0090181)2.85091995
158L-serine metabolic process (GO:0006563)2.85043148
159very-low-density lipoprotein particle assembly (GO:0034379)2.84467240
160protein localization to endoplasmic reticulum (GO:0070972)2.84001240
161regulation of complement activation (GO:0030449)2.83831677
162nitrogen cycle metabolic process (GO:0071941)2.83378782
163neutral lipid metabolic process (GO:0006638)2.82128609
164acyl-CoA metabolic process (GO:0006637)2.81466462
165thioester metabolic process (GO:0035383)2.81466462
166polyketide metabolic process (GO:0030638)2.81052605
167doxorubicin metabolic process (GO:0044598)2.81052605
168daunorubicin metabolic process (GO:0044597)2.81052605
169positive regulation of glomerulus development (GO:0090193)2.79209910
170drug metabolic process (GO:0017144)2.76001897
171regulation of macrophage derived foam cell differentiation (GO:0010743)2.74316836
172alanine transport (GO:0032328)2.73127318
173regulation of cholesterol storage (GO:0010885)2.71442552
174protein heterotrimerization (GO:0070208)2.69175566
175acetyl-CoA metabolic process (GO:0006084)2.67929810
176positive regulation of protein kinase C signaling (GO:0090037)2.65390257
177polyol transport (GO:0015791)2.64933574
178somite development (GO:0061053)2.64793348
179alkaloid metabolic process (GO:0009820)2.63676258
180positive regulation of lipid catabolic process (GO:0050996)2.62811432
181NADH metabolic process (GO:0006734)2.60469286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.76595671
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.98689224
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.82324255
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.62565192
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.42996880
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.36600036
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.09550103
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.94214364
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.57708338
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.42364633
11EZH2_22144423_ChIP-Seq_EOC_Human3.19496401
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.17928356
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.08106373
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91573145
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75097644
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71510348
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68045287
18ZNF274_21170338_ChIP-Seq_K562_Hela2.38915291
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28277764
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24842178
21VDR_22108803_ChIP-Seq_LS180_Human2.21102825
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.18544006
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.17391963
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.16710689
25GBX2_23144817_ChIP-Seq_PC3_Human2.16634871
26IRF8_22096565_ChIP-ChIP_GC-B_Human2.07683794
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.00964281
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.98075228
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94344452
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92184569
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91034213
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.82441598
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.81733274
34* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.76958021
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74144489
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73979935
37DCP1A_22483619_ChIP-Seq_HELA_Human1.71498341
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70644602
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69202593
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.69117338
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.68320441
42BCAT_22108803_ChIP-Seq_LS180_Human1.67563583
43* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66826831
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66402793
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61449582
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.56819986
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56590703
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52390719
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.52038355
50IGF1R_20145208_ChIP-Seq_DFB_Human1.49868101
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.47765860
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46207295
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39731859
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.38981246
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38538870
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38506386
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.37348106
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35394629
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.33629473
60ERA_21632823_ChIP-Seq_H3396_Human1.32834729
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29670023
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29573178
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29431889
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26532884
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24714079
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24609459
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24609459
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.22819607
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21382536
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19004996
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18548642
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17868690
73STAT1_20625510_ChIP-Seq_HELA_Human1.17279106
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16911813
75TAF2_19829295_ChIP-Seq_ESCs_Human1.16856142
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15945569
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15424791
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14908822
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.14755996
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13709668
81MYC_18940864_ChIP-ChIP_HL60_Human1.13647608
82NANOG_20526341_ChIP-Seq_ESCs_Human1.13488534
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13481530
84XRN2_22483619_ChIP-Seq_HELA_Human1.12659316
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12289338
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12200455
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11438636
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11333569
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10902416
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10847712
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08828895
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.08828895
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08288278
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08045097
95JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07864098
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07829921
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.07640840
98SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07197896
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06398220
100P300_19829295_ChIP-Seq_ESCs_Human1.05649697
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04218961
102AR_25329375_ChIP-Seq_VCAP_Human1.04145568
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03987920
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03164247
105CJUN_26792858_Chip-Seq_BT549_Human1.02030458
106FOXH1_21741376_ChIP-Seq_ESCs_Human1.01610748
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01369182
108CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00656187
109CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00358185
110NCOR_22424771_ChIP-Seq_293T_Human1.00295670
111TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00201598
112CBP_21632823_ChIP-Seq_H3396_Human0.99404451
113ER_23166858_ChIP-Seq_MCF-7_Human0.99399768
114CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99327530
115BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98611184
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98577593
117STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98338236
118SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98337306
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98255393
120* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98069913
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97191137
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.97072992
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96887352
124P53_21459846_ChIP-Seq_SAOS-2_Human0.96610027
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96352480
126MYC_19829295_ChIP-Seq_ESCs_Human0.95068360
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94671456
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94585375
129TCF4_22108803_ChIP-Seq_LS180_Human0.94208652
130* CTCF_27219007_Chip-Seq_Bcells_Human0.93539591
131CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93413938
132AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93283055
133REST_21632747_ChIP-Seq_MESCs_Mouse0.91813002
134FOXH1_21741376_ChIP-Seq_EPCs_Human0.91324968
135JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91299073
136STAT3_23295773_ChIP-Seq_U87_Human0.91091499
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90891399
138NANOG_19829295_ChIP-Seq_ESCs_Human0.90637560
139SOX2_19829295_ChIP-Seq_ESCs_Human0.90637560
140FUS_26573619_Chip-Seq_HEK293_Human0.90600629
141TP53_22573176_ChIP-Seq_HFKS_Human0.90274273
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90264530
143IRF1_19129219_ChIP-ChIP_H3396_Human0.89739349
144AR_20517297_ChIP-Seq_VCAP_Human0.88813083
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88716782
146HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88453578
147TP63_17297297_ChIP-ChIP_HaCaT_Human0.88379885
148FOXP3_21729870_ChIP-Seq_TREG_Human0.88049923
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87144024
150CBP_20019798_ChIP-Seq_JUKART_Human0.87123929
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87123929
152TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86348392
153SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86308604
154IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86276919
155VDR_23849224_ChIP-Seq_CD4+_Human0.85982956
156MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85475642
157SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85172597
158SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85089874
159SMAD4_21799915_ChIP-Seq_A2780_Human0.84859899
160RAC3_21632823_ChIP-Seq_H3396_Human0.84759151
161NOTCH1_21737748_ChIP-Seq_TLL_Human0.81146619
162RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78018176
163* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76091708
164HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76060405
165OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75659926
166CSB_26484114_Chip-Seq_FIBROBLAST_Human0.74619007
167TET1_21451524_ChIP-Seq_MESCs_Mouse0.74240494
168BCL6_27268052_Chip-Seq_Bcells_Human0.73724908
169THAP11_20581084_ChIP-Seq_MESCs_Mouse0.73339711
170HTT_18923047_ChIP-ChIP_STHdh_Human0.72893004
171PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72863777
172POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.72771948
173SOX17_20123909_ChIP-Seq_XEN_Mouse0.71609112
174MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.70698761
175IRF8_21731497_ChIP-ChIP_J774_Mouse0.70507727
176EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.70501942
177CTCF_20526341_ChIP-Seq_ESCs_Human0.70349539
178BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70012021
179CTCF_26484167_Chip-Seq_Bcells_Mouse0.68711400
180NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.68470166
181GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.67710489
182STAT4_19710469_ChIP-ChIP_TH1__Mouse0.67371729
183CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.67356149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.12118096
2MP0005360_urolithiasis4.62715544
3MP0004130_abnormal_muscle_cell4.16379490
4* MP0003011_delayed_dark_adaptation3.86404119
5MP0005085_abnormal_gallbladder_physiolo3.76868633
6MP0004019_abnormal_vitamin_homeostasis3.75331756
7MP0009379_abnormal_foot_pigmentation3.73833514
8MP0009840_abnormal_foam_cell3.49581904
9MP0005365_abnormal_bile_salt3.28812180
10MP0008875_abnormal_xenobiotic_pharmacok3.16535100
11MP0003806_abnormal_nucleotide_metabolis2.90580861
12MP0000372_irregular_coat_pigmentation2.82647339
13MP0003136_yellow_coat_color2.81229399
14MP0003252_abnormal_bile_duct2.76354820
15MP0005332_abnormal_amino_acid2.70330252
16MP0003186_abnormal_redox_activity2.66525771
17MP0008004_abnormal_stomach_pH2.65216041
18MP0010329_abnormal_lipoprotein_level2.54553568
19MP0001764_abnormal_homeostasis2.40139760
20MP0005375_adipose_tissue_phenotype2.38235301
21MP0003959_abnormal_lean_body2.15063600
22MP0005646_abnormal_pituitary_gland2.03738996
23MP0009384_cardiac_valve_regurgitation2.03539678
24MP0001958_emphysema1.88150843
25MP0003950_abnormal_plasma_membrane1.86802594
26MP0005535_abnormal_body_temperature1.85434984
27MP0009115_abnormal_fat_cell1.83029330
28MP0005334_abnormal_fat_pad1.79842933
29MP0009697_abnormal_copulation1.77267458
30MP0003279_aneurysm1.75989905
31MP0001853_heart_inflammation1.75009016
32MP0004185_abnormal_adipocyte_glucose1.71498337
33MP0005448_abnormal_energy_balance1.69576625
34MP0000751_myopathy1.67054765
35MP0002876_abnormal_thyroid_physiology1.65245942
36MP0002970_abnormal_white_adipose1.59823122
37MP0005075_abnormal_melanosome_morpholog1.53848644
38MP0000003_abnormal_adipose_tissue1.51934774
39MP0000566_synostosis1.51394628
40MP0002138_abnormal_hepatobiliary_system1.51014290
41MP0006276_abnormal_autonomic_nervous1.49976255
42MP0000013_abnormal_adipose_tissue1.42670846
43MP0005084_abnormal_gallbladder_morpholo1.41010503
44MP0004381_abnormal_hair_follicle1.39072369
45MP0003195_calcinosis1.38794678
46MP0009764_decreased_sensitivity_to1.38448702
47MP0004215_abnormal_myocardial_fiber1.35679349
48MP0005083_abnormal_biliary_tract1.30334848
49MP0003656_abnormal_erythrocyte_physiolo1.30254730
50MP0005584_abnormal_enzyme/coenzyme_acti1.28632939
51MP0002132_abnormal_respiratory_system1.28156161
52MP0003191_abnormal_cellular_cholesterol1.27135624
53MP0000749_muscle_degeneration1.26802481
54MP0001324_abnormal_eye_pigmentation1.25263195
55MP0001661_extended_life_span1.23919948
56MP0005408_hypopigmentation1.22566895
57MP0005452_abnormal_adipose_tissue1.20465149
58MP0002638_abnormal_pupillary_reflex1.19847897
59MP0005666_abnormal_adipose_tissue1.18218770
60MP0005379_endocrine/exocrine_gland_phen1.17411104
61MP0000609_abnormal_liver_physiology1.16840752
62MP0009643_abnormal_urine_homeostasis1.16728162
63MP0001666_abnormal_nutrient_absorption1.16531731
64MP0004145_abnormal_muscle_electrophysio1.15861504
65MP0001542_abnormal_bone_strength1.15621958
66MP0003724_increased_susceptibility_to1.14150530
67MP0001501_abnormal_sleep_pattern1.14097818
68MP0002102_abnormal_ear_morphology1.13742929
69MP0002118_abnormal_lipid_homeostasis1.13119833
70* MP0005253_abnormal_eye_physiology1.11003771
71MP0005319_abnormal_enzyme/_coenzyme1.10328936
72MP0006036_abnormal_mitochondrial_physio1.07494975
73MP0002909_abnormal_adrenal_gland1.06924055
74MP0006138_congestive_heart_failure1.06193406
75MP0005636_abnormal_mineral_homeostasis1.04553642
76MP0003646_muscle_fatigue1.04154056
77MP0002078_abnormal_glucose_homeostasis1.04053681
78MP0003718_maternal_effect1.03945954
79MP0008775_abnormal_heart_ventricle1.03695367
80MP0005409_darkened_coat_color1.03636281
81MP0002928_abnormal_bile_duct1.02269184
82MP0000230_abnormal_systemic_arterial1.01198005
83MP0003690_abnormal_glial_cell1.00553526
84MP0000049_abnormal_middle_ear0.98670411
85MP0005395_other_phenotype0.96419240
86MP0002933_joint_inflammation0.95966806
87MP0005167_abnormal_blood-brain_barrier0.95183878
88MP0008872_abnormal_physiological_respon0.91932805
89* MP0005551_abnormal_eye_electrophysiolog0.91326262
90MP0010368_abnormal_lymphatic_system0.89824605
91MP0000015_abnormal_ear_pigmentation0.89823155
92MP0002653_abnormal_ependyma_morphology0.89202096
93MP0008469_abnormal_protein_level0.88884295
94MP0000750_abnormal_muscle_regeneration0.88839240
95MP0006072_abnormal_retinal_apoptosis0.88376311
96MP0005220_abnormal_exocrine_pancreas0.86762371
97MP0003879_abnormal_hair_cell0.86567040
98MP0002971_abnormal_brown_adipose0.86453027
99MP0005257_abnormal_intraocular_pressure0.86006241
100MP0001968_abnormal_touch/_nociception0.85483597
101MP0001440_abnormal_grooming_behavior0.85119500
102MP0005385_cardiovascular_system_phenoty0.84465874
103MP0001544_abnormal_cardiovascular_syste0.84465874
104MP0009780_abnormal_chondrocyte_physiolo0.80402094
105MP0003137_abnormal_impulse_conducting0.78533839
106MP0005503_abnormal_tendon_morphology0.78493439
107MP0005195_abnormal_posterior_eye0.78159059
108MP0004142_abnormal_muscle_tone0.76412797
109MP0005376_homeostasis/metabolism_phenot0.74987117
110MP0002733_abnormal_thermal_nociception0.74861771
111MP0005423_abnormal_somatic_nervous0.74419789
112MP0002168_other_aberrant_phenotype0.74199235
113MP0003953_abnormal_hormone_level0.74159807
114MP0005620_abnormal_muscle_contractility0.73962994
115MP0005645_abnormal_hypothalamus_physiol0.73471962
116MP0002736_abnormal_nociception_after0.73080803
117MP0003828_pulmonary_edema0.72989591
118MP0001502_abnormal_circadian_rhythm0.72694256
119MP0002938_white_spotting0.72069345
120MP0005266_abnormal_metabolism0.71700823
121MP0002295_abnormal_pulmonary_circulatio0.71280004
122MP0009763_increased_sensitivity_to0.68957061
123MP0003868_abnormal_feces_composition0.66334492
124MP0002108_abnormal_muscle_morphology0.65808909
125MP0009642_abnormal_blood_homeostasis0.65696987
126MP0001270_distended_abdomen0.64563454
127MP0000613_abnormal_salivary_gland0.63541944
128MP0000249_abnormal_blood_vessel0.62067325
129MP0002249_abnormal_larynx_morphology0.61826439
130MP0009053_abnormal_anal_canal0.61309230
131MP0004924_abnormal_behavior0.61272920
132MP0005386_behavior/neurological_phenoty0.61272920
133MP0001756_abnormal_urination0.60838425
134MP0000598_abnormal_liver_morphology0.59140062
135MP0002272_abnormal_nervous_system0.58085375
136MP0004043_abnormal_pH_regulation0.57945252
137MP0000343_altered_response_to0.57901036
138MP0004883_abnormal_blood_vessel0.57537378
139MP0000604_amyloidosis0.57218097
140MP0000759_abnormal_skeletal_muscle0.56278584
141MP0005171_absent_coat_pigmentation0.55948986
142MP0005197_abnormal_uvea_morphology0.55316576
143MP0008438_abnormal_cutaneous_collagen0.55065374
144MP0005670_abnormal_white_adipose0.54537677
145MP0003329_amyloid_beta_deposits0.52855728
146MP0005501_abnormal_skin_physiology0.50599433
147MP0003938_abnormal_ear_development0.49977635
148MP0001944_abnormal_pancreas_morphology0.49765811
149MP0000685_abnormal_immune_system0.49692544
150MP0005595_abnormal_vascular_smooth0.49481795
151MP0002163_abnormal_gland_morphology0.49283957
152MP0002095_abnormal_skin_pigmentation0.49036942
153MP0001986_abnormal_taste_sensitivity0.48516321
154MP0000631_abnormal_neuroendocrine_gland0.48128989
155MP0003638_abnormal_response/metabolism_0.46137082
156MP0001663_abnormal_digestive_system0.46031029
157MP0000639_abnormal_adrenal_gland0.45714078
158MP0002136_abnormal_kidney_physiology0.45495695

Predicted human phenotypes

RankGene SetZ-score
1Hypoalphalipoproteinemia (HP:0003233)5.26412238
2Oligomenorrhea (HP:0000876)4.72364087
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.55780644
4Congenital stationary night blindness (HP:0007642)4.36254987
5Hypolipoproteinemia (HP:0010981)4.25387470
6Vascular calcification (HP:0004934)4.21102017
7Abnormality of renal resorption (HP:0011038)4.04432520
8Xanthomatosis (HP:0000991)3.86040812
9Prolonged partial thromboplastin time (HP:0003645)3.83135288
10Hyperlipoproteinemia (HP:0010980)3.79158622
11Renal Fanconi syndrome (HP:0001994)3.73295530
12Cardiovascular calcification (HP:0011915)3.73085732
13Hyperglycinemia (HP:0002154)3.72752584
14Dry hair (HP:0011359)3.66990540
15Hyperglycinuria (HP:0003108)3.66816256
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.64608540
17Hepatic necrosis (HP:0002605)3.58087160
18Deep venous thrombosis (HP:0002625)3.55281523
19Tubulointerstitial nephritis (HP:0001970)3.54861458
20Intrahepatic cholestasis (HP:0001406)3.48614598
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.45110034
22Hepatocellular necrosis (HP:0001404)3.39907407
23Decreased central vision (HP:0007663)3.36309096
24Abnormality of serine family amino acid metabolism (HP:0010894)3.31822893
25Abnormality of glycine metabolism (HP:0010895)3.31822893
26Mitochondrial inheritance (HP:0001427)3.27322935
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.19015947
28Attenuation of retinal blood vessels (HP:0007843)3.18143648
29Epidermoid cyst (HP:0200040)3.16003196
30Hypobetalipoproteinemia (HP:0003563)3.15822258
31Abnormal hemoglobin (HP:0011902)3.14971504
32Type 2 muscle fiber atrophy (HP:0003554)3.14246055
33Increased hepatocellular lipid droplets (HP:0006565)3.07066116
34Abnormality of fatty-acid metabolism (HP:0004359)3.06353769
35Lipid accumulation in hepatocytes (HP:0006561)3.05707870
36Hyperalaninemia (HP:0003348)2.96060148
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.96060148
38Abnormality of alanine metabolism (HP:0010916)2.96060148
39Hyperammonemia (HP:0001987)2.94898109
40Chronic hepatic failure (HP:0100626)2.93188933
41Lethargy (HP:0001254)2.92051767
42Acanthosis nigricans (HP:0000956)2.91909718
43Cerebral edema (HP:0002181)2.91738923
44Aplasia/hypoplasia of the uterus (HP:0008684)2.87193625
45Delayed CNS myelination (HP:0002188)2.85679394
46Generalized aminoaciduria (HP:0002909)2.85610856
47Acute encephalopathy (HP:0006846)2.84830407
48Hypoplasia of the uterus (HP:0000013)2.79438587
49Acute necrotizing encephalopathy (HP:0006965)2.78231318
50Polyphagia (HP:0002591)2.77537020
51Hypoglycemic coma (HP:0001325)2.76202785
52Increased CSF lactate (HP:0002490)2.75772366
53Pigmentary retinal degeneration (HP:0001146)2.71161115
54Ketosis (HP:0001946)2.70295806
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.68822513
56Popliteal pterygium (HP:0009756)2.66990559
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.61630903
58Aplasia of the musculature (HP:0100854)2.59892719
59Abnormal mitochondria in muscle tissue (HP:0008316)2.58634786
60Gowers sign (HP:0003391)2.58360601
61Glycosuria (HP:0003076)2.55418765
62Abnormality of urine glucose concentration (HP:0011016)2.55418765
63Increased intramyocellular lipid droplets (HP:0012240)2.54996014
64Increased muscle lipid content (HP:0009058)2.54056634
65Increased corneal curvature (HP:0100692)2.51283058
66Keratoconus (HP:0000563)2.51283058
67Muscle fiber atrophy (HP:0100295)2.50756941
68Hemorrhage of the eye (HP:0011885)2.49565778
69Mesangial abnormality (HP:0001966)2.45736766
70Abnormal rod and cone electroretinograms (HP:0008323)2.45598783
71Abnormal eating behavior (HP:0100738)2.44327288
72Exertional dyspnea (HP:0002875)2.43061385
73Prominent supraorbital ridges (HP:0000336)2.42943704
74Abnormality of midbrain morphology (HP:0002418)2.41862602
75Molar tooth sign on MRI (HP:0002419)2.41862602
76Joint hemorrhage (HP:0005261)2.40733642
77Dicarboxylic aciduria (HP:0003215)2.40080330
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40080330
79Ketoacidosis (HP:0001993)2.39098654
80Abnormality of the fovea (HP:0000493)2.33128767
81Short middle phalanx of the 5th finger (HP:0004220)2.32704086
82Abnormality of methionine metabolism (HP:0010901)2.31519084
83Infantile muscular hypotonia (HP:0008947)2.30698686
84Pendular nystagmus (HP:0012043)2.30430658
85Pancreatic fibrosis (HP:0100732)2.28575910
86Concave nail (HP:0001598)2.27857156
87Bony spicule pigmentary retinopathy (HP:0007737)2.27585586
88Bone cyst (HP:0012062)2.25683880
89Complement deficiency (HP:0004431)2.25165900
90CNS demyelination (HP:0007305)2.23732788
91Choroideremia (HP:0001139)2.22685389
92Abnormality of the neuromuscular junction (HP:0003398)2.22159995
93Fatigable weakness (HP:0003473)2.22159995
94Abnormality of the renal cortex (HP:0011035)2.20623410
95Aplasia involving bones of the upper limbs (HP:0009823)2.20529464
96Aplasia of the phalanges of the hand (HP:0009802)2.20529464
97Aplasia involving bones of the extremities (HP:0009825)2.20529464
98Hydroxyprolinuria (HP:0003080)2.20517788
99Abnormality of proline metabolism (HP:0010907)2.20517788
100Pancreatic cysts (HP:0001737)2.18747244
101Abnormality of glutamine family amino acid metabolism (HP:0010902)2.18547514
102Type II lissencephaly (HP:0007260)2.18249202
103Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18017280
104Abnormality of sulfur amino acid metabolism (HP:0004339)2.17917192
105Rib fusion (HP:0000902)2.17601026
106True hermaphroditism (HP:0010459)2.16525877
107Decreased circulating renin level (HP:0003351)2.16341660
108Myotonia (HP:0002486)2.15464312
109Hyperphosphaturia (HP:0003109)2.14629473
110Progressive macrocephaly (HP:0004481)2.13916930
111Systemic lupus erythematosus (HP:0002725)2.13292568
112Abnormality of serum amino acid levels (HP:0003112)2.13198495
113Inability to walk (HP:0002540)2.12090411
114Adactyly (HP:0009776)2.10860027
115Renal tubular dysfunction (HP:0000124)2.10754626
116Renal cortical cysts (HP:0000803)2.10012550
117Increased serum lactate (HP:0002151)2.09155392
118Lactic acidosis (HP:0003128)2.08777867
119Fat malabsorption (HP:0002630)2.07907865
120Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07889517
121Abnormal biliary tract physiology (HP:0012439)2.07715692
122Bile duct proliferation (HP:0001408)2.07715692
123Exercise intolerance (HP:0003546)2.07058282
124Metabolic acidosis (HP:0001942)2.06254726
125Abolished electroretinogram (ERG) (HP:0000550)2.04714778
126Insulin resistance (HP:0000855)2.03094986
127Hypoplastic left heart (HP:0004383)2.01954230
128Respiratory failure (HP:0002878)2.01803571
129Abnormality of complement system (HP:0005339)2.01201364
130Abnormality of permanent molar morphology (HP:0011071)2.01118503
131Abnormality of the dental root (HP:0006486)2.01118503
132Taurodontia (HP:0000679)2.01118503
133Nephronophthisis (HP:0000090)1.99688690
134Hypertriglyceridemia (HP:0002155)1.99626907
135Fetal akinesia sequence (HP:0001989)1.99392886
136Abnormality of molar morphology (HP:0011070)1.97599637
137Abnormality of molar (HP:0011077)1.97599637
138Nausea (HP:0002018)1.97430085
139Abnormality of the common coagulation pathway (HP:0010990)1.96152785
140Macrocytic anemia (HP:0001972)1.95937506
141Abnormality of placental membranes (HP:0011409)1.95439513
142Amniotic constriction ring (HP:0009775)1.95439513
143Abnormality of pyrimidine metabolism (HP:0004353)1.94580993
144Respiratory difficulties (HP:0002880)1.94173271
145Vomiting (HP:0002013)1.93703619
146Abnormality of the dental pulp (HP:0006479)1.91916077
147Hypophosphatemic rickets (HP:0004912)1.90918681
148Cerebral palsy (HP:0100021)1.90133428
149Thyroid-stimulating hormone excess (HP:0002925)1.89799469
150Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87744240
151Abnormality of nucleobase metabolism (HP:0010932)1.86814930
152Abnormality of vitamin metabolism (HP:0100508)1.86680662
153Increased purine levels (HP:0004368)1.86395299
154Skin nodule (HP:0200036)1.86228253
155Congenital, generalized hypertrichosis (HP:0004540)1.86036055
156Aplasia/Hypoplasia involving the musculature (HP:0001460)1.85223355
157Abnormal drinking behavior (HP:0030082)1.84591000
158Polydipsia (HP:0001959)1.84591000
159Insulin-resistant diabetes mellitus (HP:0000831)1.82826146
160Macular degeneration (HP:0000608)1.82524273
161Opisthotonus (HP:0002179)1.81670645
162Easy fatigability (HP:0003388)1.80789006
163Tubular atrophy (HP:0000092)1.79256864

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.70019316
2NME24.17584047
3NEK93.28516385
4BCKDK3.27594039
5TIE12.69836154
6IRAK32.64640413
7FRK2.44247804
8CASK2.10645222
9IRAK42.07686645
10BMPR1B2.04254043
11TESK21.99486348
12STK391.83231440
13MAP4K21.81196413
14IRAK21.79846049
15WNK31.75637178
16FGFR41.72902132
17CAMKK21.71447905
18TGFBR21.69406529
19PIM21.68415211
20PRKAA21.67706850
21TAOK31.65418421
22IRAK11.62655993
23MAPKAPK31.59956414
24CAMK11.58947294
25WNK41.56887154
26KDR1.55668255
27NUAK11.51618686
28STK161.48756207
29PBK1.48060049
30EIF2AK11.47233749
31CCNB11.44820241
32MAPK151.44185157
33PTK61.40720639
34DAPK21.38546225
35MYLK1.37445922
36MARK11.35874420
37MST41.35721130
38DDR21.34252133
39TNIK1.33990235
40PDK21.22543251
41GRK11.17396290
42GRK51.16615979
43ADRBK21.15586167
44CDK191.14937646
45ZAK1.14751471
46MAPK131.14040971
47ACVR1B1.11330359
48BLK1.11141049
49PAK31.10897989
50MAPK121.07519398
51EPHA31.06360122
52MAP2K11.06088946
53EPHB21.06085807
54DAPK31.05258771
55DYRK21.03251398
56TBK11.03088133
57MAP2K20.98058547
58PRKCQ0.97806599
59SIK10.97682381
60NLK0.97383596
61ABL20.95369679
62PRKACG0.94607515
63MKNK20.94511697
64BUB10.92528497
65ERN10.92419524
66TEC0.90856185
67PIK3CG0.89545805
68VRK10.89508369
69LMTK20.89121249
70PRKAA10.88087029
71IKBKE0.88015330
72TESK10.87539860
73LIMK10.87512388
74MAP3K40.85811943
75PKN10.85252227
76KIT0.83246681
77NME10.81923719
78PHKG20.81513286
79PHKG10.81513286
80TXK0.81424446
81MAP3K110.81417838
82MAPK40.81384081
83PINK10.79991628
84INSRR0.77378931
85TGFBR10.76107734
86PRKG10.74464333
87ILK0.74130112
88DYRK1B0.70882977
89FLT30.70606313
90BTK0.67608033
91MAP2K40.67233039
92TSSK60.65285052
93ADRBK10.64440835
94PRKCG0.64384988
95STK110.64114919
96FES0.63998599
97MAP3K50.63825898
98TYK20.62683812
99MAPK110.62507396
100MAPK70.61926675
101CAMK2G0.61883190
102NEK60.61859391
103MOS0.61523219
104CSK0.60124743
105CSNK1G20.59632955
106CAMK1D0.59360796
107IKBKB0.58948470
108ZAP700.56550222
109LRRK20.54625647
110PRKACB0.53544744
111MST1R0.51262868
112CDK80.51196363
113PRKCD0.51033285
114MELK0.50440051
115ABL10.48048749
116OXSR10.47410196
117CAMK2A0.47274382
118PTK2B0.46709830
119PRKCE0.46497939
120CSNK2A10.45582917
121GSK3A0.45313042
122PIK3CA0.45232703
123AURKA0.45143160
124OBSCN0.45130761
125PRKCZ0.44193246
126MAP2K60.43739557
127MAPKAPK50.43689203
128JAK20.42717730
129ROCK10.42336286
130IGF1R0.41002432
131LYN0.40159084
132MUSK0.40075079
133PRKCA0.39777935
134LCK0.38143053
135TNK20.37681396
136PRKCI0.37344434
137MAP3K140.37188949
138MAP2K70.37157772
139MAP4K10.36427227
140MAPK30.35338133
141CSNK1A10.34446872
142CSNK2A20.33859401
143EIF2AK30.33761313
144CAMK2D0.33176113
145GRK60.32853754
146STK38L0.31987005
147PDPK10.31683455
148CSNK1D0.31460244
149DYRK1A0.31111497
150GRK70.30435429
151PRKACA0.30222189
152RPS6KA30.30109678
153NTRK30.29791116

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000403.13322784
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.07144966
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.73619405
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55684942
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48924362
6Nitrogen metabolism_Homo sapiens_hsa009102.46896891
7Ribosome_Homo sapiens_hsa030102.46230378
8Fatty acid degradation_Homo sapiens_hsa000712.30079510
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26521034
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17485835
11Propanoate metabolism_Homo sapiens_hsa006402.12672462
12Tryptophan metabolism_Homo sapiens_hsa003802.10295436
13Peroxisome_Homo sapiens_hsa041462.05846897
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03150771
15Fatty acid elongation_Homo sapiens_hsa000621.99633818
16Oxidative phosphorylation_Homo sapiens_hsa001901.97321989
17Complement and coagulation cascades_Homo sapiens_hsa046101.94490433
18Butanoate metabolism_Homo sapiens_hsa006501.88831910
19Arginine biosynthesis_Homo sapiens_hsa002201.87400777
20Sulfur relay system_Homo sapiens_hsa041221.86894784
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.86855749
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86176122
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.83261577
24Chemical carcinogenesis_Homo sapiens_hsa052041.80177969
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.76613462
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73873137
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72654199
28* Retinol metabolism_Homo sapiens_hsa008301.66588433
29Fatty acid metabolism_Homo sapiens_hsa012121.64746487
30Starch and sucrose metabolism_Homo sapiens_hsa005001.63440842
31Parkinsons disease_Homo sapiens_hsa050121.63366658
32Vitamin digestion and absorption_Homo sapiens_hsa049771.55692721
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.53563105
34Tyrosine metabolism_Homo sapiens_hsa003501.52892249
35Folate biosynthesis_Homo sapiens_hsa007901.52111883
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.51439848
37beta-Alanine metabolism_Homo sapiens_hsa004101.51406766
38PPAR signaling pathway_Homo sapiens_hsa033201.49717266
39Phototransduction_Homo sapiens_hsa047441.44211194
40Steroid biosynthesis_Homo sapiens_hsa001001.40636709
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37823490
42Histidine metabolism_Homo sapiens_hsa003401.32780396
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.31534115
44Protein export_Homo sapiens_hsa030601.28192633
45Carbon metabolism_Homo sapiens_hsa012001.25984726
46Pyruvate metabolism_Homo sapiens_hsa006201.23759936
47Bile secretion_Homo sapiens_hsa049761.15372756
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14702662
49RNA polymerase_Homo sapiens_hsa030201.14282365
50Pentose phosphate pathway_Homo sapiens_hsa000301.13034639
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12973809
52Glutathione metabolism_Homo sapiens_hsa004801.11657226
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.11224167
54Sulfur metabolism_Homo sapiens_hsa009201.09740080
55Biosynthesis of amino acids_Homo sapiens_hsa012301.07464914
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07193877
57Huntingtons disease_Homo sapiens_hsa050161.02605406
58Alzheimers disease_Homo sapiens_hsa050101.02352394
59Arginine and proline metabolism_Homo sapiens_hsa003301.02237562
60Phenylalanine metabolism_Homo sapiens_hsa003601.01245504
61Staphylococcus aureus infection_Homo sapiens_hsa051500.96884581
62Selenocompound metabolism_Homo sapiens_hsa004500.95852989
63One carbon pool by folate_Homo sapiens_hsa006700.93406017
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93125214
65Metabolic pathways_Homo sapiens_hsa011000.89723119
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89690122
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89508400
68Ovarian steroidogenesis_Homo sapiens_hsa049130.88815812
69Caffeine metabolism_Homo sapiens_hsa002320.88243018
70Ether lipid metabolism_Homo sapiens_hsa005650.87001190
71Other glycan degradation_Homo sapiens_hsa005110.85860897
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.85826043
73Pyrimidine metabolism_Homo sapiens_hsa002400.84843092
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.84615658
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84489137
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83459676
77Proteasome_Homo sapiens_hsa030500.79024107
78Fat digestion and absorption_Homo sapiens_hsa049750.78338008
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75977318
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72128978
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66976755
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.66936857
83Arachidonic acid metabolism_Homo sapiens_hsa005900.63085918
84Galactose metabolism_Homo sapiens_hsa000520.62779169
85ABC transporters_Homo sapiens_hsa020100.61159017
86Vitamin B6 metabolism_Homo sapiens_hsa007500.54459247
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52681669
88Glycerolipid metabolism_Homo sapiens_hsa005610.49887810
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49305308
90Sphingolipid metabolism_Homo sapiens_hsa006000.45971612
91AMPK signaling pathway_Homo sapiens_hsa041520.45496522
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45419728
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.44426858
94Fructose and mannose metabolism_Homo sapiens_hsa000510.43775672
95DNA replication_Homo sapiens_hsa030300.42969441
96Morphine addiction_Homo sapiens_hsa050320.41862355
97Nucleotide excision repair_Homo sapiens_hsa034200.39275127
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36428121
99Purine metabolism_Homo sapiens_hsa002300.32961573
100Mineral absorption_Homo sapiens_hsa049780.30091800
101Regulation of autophagy_Homo sapiens_hsa041400.29774801
102Linoleic acid metabolism_Homo sapiens_hsa005910.29688480
103Circadian rhythm_Homo sapiens_hsa047100.27018831
104Cardiac muscle contraction_Homo sapiens_hsa042600.25807403
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25534951
106Primary immunodeficiency_Homo sapiens_hsa053400.25523530
107Renin secretion_Homo sapiens_hsa049240.24673290
108Malaria_Homo sapiens_hsa051440.22035988
109Homologous recombination_Homo sapiens_hsa034400.21669559
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20749079
111Serotonergic synapse_Homo sapiens_hsa047260.20662009
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20560330
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20477658
114Lysine degradation_Homo sapiens_hsa003100.19667808
115Dilated cardiomyopathy_Homo sapiens_hsa054140.19075024
116Olfactory transduction_Homo sapiens_hsa047400.18764696
117Taste transduction_Homo sapiens_hsa047420.17815063
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.17609103
119Renin-angiotensin system_Homo sapiens_hsa046140.16253461
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14729154
121Base excision repair_Homo sapiens_hsa034100.14231800
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.13701898
123Fatty acid biosynthesis_Homo sapiens_hsa000610.12272218
124Lysosome_Homo sapiens_hsa041420.12219483

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