RDX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.31255533
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.31255533
3L-phenylalanine metabolic process (GO:0006558)4.80828437
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.80828437
5glyoxylate metabolic process (GO:0046487)3.96189841
6aromatic amino acid family catabolic process (GO:0009074)3.91645754
7alpha-linolenic acid metabolic process (GO:0036109)3.91420063
8fatty acid elongation (GO:0030497)3.84161624
9cysteine metabolic process (GO:0006534)3.66212802
10mitotic chromosome condensation (GO:0007076)3.61382887
11CENP-A containing nucleosome assembly (GO:0034080)3.58884885
12chromatin remodeling at centromere (GO:0031055)3.56540752
13mitotic metaphase plate congression (GO:0007080)3.53846396
14bile acid biosynthetic process (GO:0006699)3.53237027
15anterior/posterior axis specification, embryo (GO:0008595)3.51636788
16negative regulation of fibrinolysis (GO:0051918)3.47237783
17metaphase plate congression (GO:0051310)3.45738271
18kinetochore organization (GO:0051383)3.45159752
19lysine metabolic process (GO:0006553)3.33575736
20lysine catabolic process (GO:0006554)3.33575736
21midgut development (GO:0007494)3.29956071
22tyrosine metabolic process (GO:0006570)3.29058241
23axon ensheathment in central nervous system (GO:0032291)3.24570460
24central nervous system myelination (GO:0022010)3.24570460
25negative regulation of axon extension involved in axon guidance (GO:0048843)3.24416581
26protein carboxylation (GO:0018214)3.22730151
27peptidyl-glutamic acid carboxylation (GO:0017187)3.22730151
28regulation of fibrinolysis (GO:0051917)3.21226736
29serine family amino acid biosynthetic process (GO:0009070)3.16509495
30ethanol oxidation (GO:0006069)3.12914109
31histone exchange (GO:0043486)3.11683814
32embryonic foregut morphogenesis (GO:0048617)3.09047398
33glycine metabolic process (GO:0006544)3.04882375
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.04293719
35fibrinolysis (GO:0042730)3.02465093
36ventricular cardiac muscle cell development (GO:0055015)3.02426583
37mitotic sister chromatid cohesion (GO:0007064)3.02255721
38protein localization to kinetochore (GO:0034501)3.00643706
39regulation of centriole replication (GO:0046599)3.00315183
40anterior/posterior axis specification (GO:0009948)2.99842172
41dorsal/ventral axis specification (GO:0009950)2.98458109
42sulfur amino acid catabolic process (GO:0000098)2.97648503
43cholesterol biosynthetic process (GO:0006695)2.95783911
44regulation of protein activation cascade (GO:2000257)2.95223007
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.95193797
46response to nitrosative stress (GO:0051409)2.94637643
47serine family amino acid metabolic process (GO:0009069)2.94517992
48acetyl-CoA metabolic process (GO:0006084)2.93763452
49regulation of female gonad development (GO:2000194)2.92884889
50kynurenine metabolic process (GO:0070189)2.90897457
51urea cycle (GO:0000050)2.87857010
52urea metabolic process (GO:0019627)2.87857010
53kinetochore assembly (GO:0051382)2.86515939
54complement activation, alternative pathway (GO:0006957)2.86313325
55tryptophan metabolic process (GO:0006568)2.85739353
56bile acid metabolic process (GO:0008206)2.84296799
57fatty-acyl-CoA biosynthetic process (GO:0046949)2.83699166
58nuclear pore complex assembly (GO:0051292)2.82755305
59DNA unwinding involved in DNA replication (GO:0006268)2.81514854
60establishment of chromosome localization (GO:0051303)2.81258623
61negative regulation of fatty acid biosynthetic process (GO:0045717)2.78220909
62regulation of cardioblast differentiation (GO:0051890)2.75854860
63aspartate family amino acid catabolic process (GO:0009068)2.75345594
64neuron projection extension involved in neuron projection guidance (GO:1902284)2.74844482
65axon extension involved in axon guidance (GO:0048846)2.74844482
66protein localization to endosome (GO:0036010)2.74665959
67regulation of complement activation (GO:0030449)2.74221850
68serine family amino acid catabolic process (GO:0009071)2.73742509
69L-serine metabolic process (GO:0006563)2.72567467
70plasma lipoprotein particle clearance (GO:0034381)2.72522890
71long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.72313097
72aromatic amino acid family metabolic process (GO:0009072)2.71361902
73negative regulation of axon guidance (GO:1902668)2.71133859
74fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.70551053
75tryptophan catabolic process (GO:0006569)2.69543360
76indole-containing compound catabolic process (GO:0042436)2.69543360
77indolalkylamine catabolic process (GO:0046218)2.69543360
78primitive streak formation (GO:0090009)2.68585660
79very long-chain fatty acid metabolic process (GO:0000038)2.67053731
80DNA replication-independent nucleosome organization (GO:0034724)2.66909030
81DNA replication-independent nucleosome assembly (GO:0006336)2.66909030
82somite rostral/caudal axis specification (GO:0032525)2.65299011
83ganglion development (GO:0061548)2.65049432
84myelin maintenance (GO:0043217)2.64428686
85regulation of RNA export from nucleus (GO:0046831)2.64230787
86high-density lipoprotein particle remodeling (GO:0034375)2.63949519
87positive regulation of fatty acid beta-oxidation (GO:0032000)2.63948340
88regulation of sister chromatid cohesion (GO:0007063)2.62312968
89replication fork processing (GO:0031297)2.62104127
90resolution of meiotic recombination intermediates (GO:0000712)2.61212687
91regulation of axon extension involved in axon guidance (GO:0048841)2.61071762
92alpha-amino acid catabolic process (GO:1901606)2.60759400
93positive regulation of chromosome segregation (GO:0051984)2.60487543
94axon ensheathment (GO:0008366)2.60401688
95ensheathment of neurons (GO:0007272)2.60401688
96folic acid-containing compound biosynthetic process (GO:0009396)2.60121043
97protein K6-linked ubiquitination (GO:0085020)2.59716584
98cell migration involved in gastrulation (GO:0042074)2.59480392
99proteasome assembly (GO:0043248)2.58554161
100heme transport (GO:0015886)2.58189890
101regulation of DNA endoreduplication (GO:0032875)2.57496310
102regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.56902917
103cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.56607171
104regulation of transforming growth factor beta2 production (GO:0032909)2.55704892
105DNA double-strand break processing (GO:0000729)2.55584790
106nuclear pore organization (GO:0006999)2.55202061
107myelination (GO:0042552)2.55063081
108embryonic retina morphogenesis in camera-type eye (GO:0060059)2.54433988
109nitrogen cycle metabolic process (GO:0071941)2.53927316
110negative regulation of activin receptor signaling pathway (GO:0032926)2.51308984
111sterol biosynthetic process (GO:0016126)2.50494325
112sister chromatid segregation (GO:0000819)2.50406496
113one-carbon metabolic process (GO:0006730)2.48088204
114very-low-density lipoprotein particle assembly (GO:0034379)2.46973963
115regulation of mesoderm development (GO:2000380)2.46493705
116acyl-CoA biosynthetic process (GO:0071616)2.46118182
117thioester biosynthetic process (GO:0035384)2.46118182
118chondrocyte development (GO:0002063)2.45923246
119embryonic axis specification (GO:0000578)2.45379381
120histone H2A monoubiquitination (GO:0035518)2.44896228
121amino-acid betaine metabolic process (GO:0006577)2.44690426
122notochord development (GO:0030903)2.44562619
123homocysteine metabolic process (GO:0050667)2.44220078
124limb bud formation (GO:0060174)2.43719591
125citrulline biosynthetic process (GO:0019240)2.43333750
126regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.43129925
127cytoplasmic mRNA processing body assembly (GO:0033962)2.43124268
128regulation of cholesterol biosynthetic process (GO:0045540)2.41990976
129paraxial mesoderm development (GO:0048339)2.41574993
130protein-lipid complex assembly (GO:0065005)2.41427536
131acylglycerol homeostasis (GO:0055090)2.39481486
132triglyceride homeostasis (GO:0070328)2.39481486
133regulation of cholesterol metabolic process (GO:0090181)2.39479339
134retina vasculature morphogenesis in camera-type eye (GO:0061299)2.39035143
135gap junction assembly (GO:0016264)2.38984203
136DNA ligation (GO:0006266)2.36536410
137cellular ketone body metabolic process (GO:0046950)2.36432904
138cellular amino acid catabolic process (GO:0009063)2.35955752
139regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.35797661
140mitotic sister chromatid segregation (GO:0000070)2.35621399
141spindle checkpoint (GO:0031577)2.35081055
142coenzyme catabolic process (GO:0009109)2.34850478
143regulation of axon guidance (GO:1902667)2.34047038
144short-chain fatty acid metabolic process (GO:0046459)2.33943614
145regulation of triglyceride catabolic process (GO:0010896)2.33868250
146protein localization to chromosome, centromeric region (GO:0071459)2.33774232
147regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.33170741
148regulation of spindle organization (GO:0090224)2.32459664
149glucocorticoid biosynthetic process (GO:0006704)2.31823170
150glomerular filtration (GO:0003094)2.31640160
151mitotic G2/M transition checkpoint (GO:0044818)2.30133919
152hippo signaling (GO:0035329)2.28456358
153lymphangiogenesis (GO:0001946)2.28078170
154female gonad development (GO:0008585)2.27875432
155mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.27207066
156endoderm formation (GO:0001706)2.25884537
157negative chemotaxis (GO:0050919)2.25236735
158ectodermal placode formation (GO:0060788)2.25196105
159regulation of acyl-CoA biosynthetic process (GO:0050812)2.24849054
160atrial cardiac muscle cell action potential (GO:0086014)2.22901416
161positive regulation of protein autophosphorylation (GO:0031954)2.22746404
162regulation of centrosome cycle (GO:0046605)2.21336872
163response to follicle-stimulating hormone (GO:0032354)2.20810113
164establishment of integrated proviral latency (GO:0075713)2.20122298
165regulation of coenzyme metabolic process (GO:0051196)2.19144153
166regulation of cofactor metabolic process (GO:0051193)2.19144153
167regulation of sulfur metabolic process (GO:0042762)2.18408562
168non-recombinational repair (GO:0000726)2.17733221
169double-strand break repair via nonhomologous end joining (GO:0006303)2.17733221
170aggressive behavior (GO:0002118)2.17590449
171response to BMP (GO:0071772)2.16929531
172cellular response to BMP stimulus (GO:0071773)2.16929531
173behavioral response to ethanol (GO:0048149)2.15559391
174positive regulation of cardiac muscle cell proliferation (GO:0060045)2.14450943
175mitotic spindle organization (GO:0007052)2.12549650
176positive regulation of male gonad development (GO:2000020)2.12159877
177regulation of mitotic spindle organization (GO:0060236)2.11970611
178cell surface receptor signaling pathway involved in heart development (GO:0061311)2.11631210
179presynaptic membrane assembly (GO:0097105)2.11154842
180regulation of centrosome duplication (GO:0010824)2.11058068
181signal transduction involved in regulation of gene expression (GO:0023019)2.10294186
182artery development (GO:0060840)2.10273937
183protein neddylation (GO:0045116)2.10173728
184cardiac epithelial to mesenchymal transition (GO:0060317)2.08305533
185regulation of chromosome segregation (GO:0051983)2.05997573
186cardiac muscle cell development (GO:0055013)2.04768401
187positive regulation of cardiac muscle tissue development (GO:0055025)2.04650443
188sequestering of extracellular ligand from receptor (GO:0035581)2.03899592
189DNA replication-dependent nucleosome organization (GO:0034723)2.03687178
190DNA replication-dependent nucleosome assembly (GO:0006335)2.03687178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.19981060
2E2F7_22180533_ChIP-Seq_HELA_Human5.81550254
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.49979149
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.24516317
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.79373629
6AR_21909140_ChIP-Seq_LNCAP_Human3.78880761
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.73754784
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.58345091
9PPARA_22158963_ChIP-Seq_LIVER_Mouse3.50955281
10SALL1_21062744_ChIP-ChIP_HESCs_Human3.36601276
11CLOCK_20551151_ChIP-Seq_293T_Human2.78095131
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.59356672
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58021910
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49673403
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.48756162
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47663694
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43661341
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29074847
19SALL4_18804426_ChIP-ChIP_XEN_Mouse2.25943274
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.23638221
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.23103433
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11027094
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09849220
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.09765791
25FUS_26573619_Chip-Seq_HEK293_Human2.09438290
26WT1_19549856_ChIP-ChIP_CCG9911_Human2.07224492
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04737859
28TAF15_26573619_Chip-Seq_HEK293_Human2.01199532
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99942970
30P300_19829295_ChIP-Seq_ESCs_Human1.94416689
31ELK1_19687146_ChIP-ChIP_HELA_Human1.93134411
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88607047
33GBX2_23144817_ChIP-Seq_PC3_Human1.84838298
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81764908
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73336274
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.71888028
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69938869
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.68091279
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66603417
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65563051
41* PIAS1_25552417_ChIP-Seq_VCAP_Human1.61774014
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58814507
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58283588
44VDR_22108803_ChIP-Seq_LS180_Human1.57790855
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55226353
46SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.53818554
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53331538
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52737351
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51695548
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50616643
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49822966
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.48755367
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46862829
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45937091
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44730711
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40998527
57* SMAD4_21799915_ChIP-Seq_A2780_Human1.40449455
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38523066
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.36609174
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35204945
61CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34949083
62* E2F1_21310950_ChIP-Seq_MCF-7_Human1.34376419
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33813757
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31989285
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31694352
66* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30794710
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.27843577
68IGF1R_20145208_ChIP-Seq_DFB_Human1.27803468
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26658943
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25713558
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.24993453
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24508306
73* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22446593
74SOX17_20123909_ChIP-Seq_XEN_Mouse1.22167581
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.21516307
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.21136725
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20895166
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20457456
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19341619
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19165884
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19155740
82PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19121683
83ZNF274_21170338_ChIP-Seq_K562_Hela1.18697390
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.17235532
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17174822
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17020688
87TP53_18474530_ChIP-ChIP_U2OS_Human1.16652813
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15259283
89* CHD1_26751641_Chip-Seq_LNCaP_Human1.14759124
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14674699
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14294797
92GABP_17652178_ChIP-ChIP_JURKAT_Human1.14131654
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13965736
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13762537
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12652316
96SOX9_26525672_Chip-Seq_HEART_Mouse1.12573335
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12325148
98RNF2_27304074_Chip-Seq_NSC_Mouse1.12101393
99* CBX2_27304074_Chip-Seq_ESCs_Mouse1.12027000
100TRIM28_21343339_ChIP-Seq_HEK293_Human1.11860092
101EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10147251
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10112102
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09330833
104* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08717036
105STAT3_23295773_ChIP-Seq_U87_Human1.07995720
106* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.07868781
107BRD4_25478319_ChIP-Seq_HGPS_Human1.07239351
108ESR1_20079471_ChIP-ChIP_T-47D_Human1.06683565
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05468374
110CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05247690
111SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05042488
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04792575
113* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04606037
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04354327
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04197823
116BCAT_22108803_ChIP-Seq_LS180_Human1.03835932
117* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03411052
118YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03254939
119* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03246234
120ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03228412
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02727713
122SMAD4_21741376_ChIP-Seq_HESCs_Human1.02671410
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.02162703
124* AR_25329375_ChIP-Seq_VCAP_Human1.01917596
125* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99451839
126* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98795668
127TCF4_22108803_ChIP-Seq_LS180_Human0.98451658
128* ISL1_27105846_Chip-Seq_CPCs_Mouse0.98278084
129* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98091415
130SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97957330
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97626490
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96991789
133* CJUN_26792858_Chip-Seq_BT549_Human0.96494107
134E2F1_18555785_Chip-Seq_ESCs_Mouse0.96462456
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96223301
136* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93578965
137HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93392491
138TBX20_22080862_ChIP-Seq_HEART_Mouse0.92197147
139TBX20_22328084_ChIP-Seq_HEART_Mouse0.92197147
140* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91241691
141EWS_26573619_Chip-Seq_HEK293_Human0.89738014
142* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89283315
143* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88546969
144TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87837864
145* HNF4A_19822575_ChIP-Seq_HepG2_Human0.87357928
146* FOXA1_25552417_ChIP-Seq_VCAP_Human0.87023513
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86998478
148* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85676357
149AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85196447
150GATA6_25053715_ChIP-Seq_YYC3_Human0.85096599
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.84612846
152MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84541401
153ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84332807
154SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84073954
155* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83260475
156* GATA4_25053715_ChIP-Seq_YYC3_Human0.82590882
157GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82291837
158CDX2_22108803_ChIP-Seq_LS180_Human0.81818617
159PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81583167
160STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.81472717
161* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80650592
162ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79204026
163* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79083909
164* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78741754
165FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.77796476
166NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77494711
167NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76067458
168NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76067458
169* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75712527
170* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75712527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.22059022
2MP0005360_urolithiasis3.68222733
3MP0003806_abnormal_nucleotide_metabolis3.17810130
4MP0005085_abnormal_gallbladder_physiolo2.96589292
5MP0005365_abnormal_bile_salt2.65398939
6MP0003705_abnormal_hypodermis_morpholog2.57338781
7MP0008875_abnormal_xenobiotic_pharmacok2.38308758
8MP0010368_abnormal_lymphatic_system2.38285604
9MP0003252_abnormal_bile_duct2.22858218
10MP0004272_abnormal_basement_membrane2.02927426
11MP0003950_abnormal_plasma_membrane2.00217646
12MP0005408_hypopigmentation1.91596302
13MP0003937_abnormal_limbs/digits/tail_de1.85592828
14MP0008438_abnormal_cutaneous_collagen1.85126303
15MP0003718_maternal_effect1.81986168
16MP0009053_abnormal_anal_canal1.73771646
17MP0003941_abnormal_skin_development1.73533200
18MP0000537_abnormal_urethra_morphology1.68521112
19MP0002938_white_spotting1.68152886
20MP0005451_abnormal_body_composition1.64501028
21MP0003136_yellow_coat_color1.63149474
22MP0010678_abnormal_skin_adnexa1.62359510
23MP0009384_cardiac_valve_regurgitation1.58884464
24MP0003119_abnormal_digestive_system1.55234918
25MP0010030_abnormal_orbit_morphology1.50389096
26MP0002233_abnormal_nose_morphology1.49191592
27MP0004215_abnormal_myocardial_fiber1.46080965
28MP0005083_abnormal_biliary_tract1.43689418
29MP0005623_abnormal_meninges_morphology1.43371440
30MP0000049_abnormal_middle_ear1.40768667
31MP0009780_abnormal_chondrocyte_physiolo1.39564671
32MP0000383_abnormal_hair_follicle1.38986811
33MP0005367_renal/urinary_system_phenotyp1.37938467
34MP0000516_abnormal_urinary_system1.37938467
35MP0001915_intracranial_hemorrhage1.37228747
36MP0005171_absent_coat_pigmentation1.36460341
37MP0001730_embryonic_growth_arrest1.36103398
38MP0006054_spinal_hemorrhage1.36020089
39MP0004185_abnormal_adipocyte_glucose1.32847705
40MP0000778_abnormal_nervous_system1.32560477
41MP0005257_abnormal_intraocular_pressure1.30561195
42MP0009697_abnormal_copulation1.27631672
43MP0005332_abnormal_amino_acid1.26452032
44MP0003195_calcinosis1.25832922
45MP0010329_abnormal_lipoprotein_level1.25584309
46MP0010094_abnormal_chromosome_stability1.24720298
47MP0003121_genomic_imprinting1.24678339
48MP0001299_abnormal_eye_distance/1.24523736
49MP0000733_abnormal_muscle_development1.22739202
50MP0009840_abnormal_foam_cell1.21444385
51MP0001286_abnormal_eye_development1.20937264
52MP0000920_abnormal_myelination1.16161991
53MP0002234_abnormal_pharynx_morphology1.16120238
54MP0005380_embryogenesis_phenotype1.15168240
55MP0001672_abnormal_embryogenesis/_devel1.15168240
56MP0003567_abnormal_fetal_cardiomyocyte1.12951065
57MP0008057_abnormal_DNA_replication1.12262868
58MP0002084_abnormal_developmental_patter1.11629514
59MP0005395_other_phenotype1.11286588
60MP0001177_atelectasis1.10845588
61MP0003890_abnormal_embryonic-extraembry1.10716710
62MP0001984_abnormal_olfaction1.10263024
63MP0004197_abnormal_fetal_growth/weight/1.09878771
64MP0006292_abnormal_olfactory_placode1.09316812
65MP0000749_muscle_degeneration1.09121451
66MP0008775_abnormal_heart_ventricle1.07835183
67MP0003077_abnormal_cell_cycle1.07671578
68MP0010234_abnormal_vibrissa_follicle1.06394247
69MP0003984_embryonic_growth_retardation1.05509132
70MP0006072_abnormal_retinal_apoptosis1.05227643
71MP0002295_abnormal_pulmonary_circulatio1.05107890
72MP0002088_abnormal_embryonic_growth/wei1.04946346
73MP0001879_abnormal_lymphatic_vessel1.03048080
74MP0003690_abnormal_glial_cell1.02538144
75MP0005187_abnormal_penis_morphology1.01878502
76MP0008932_abnormal_embryonic_tissue1.01871112
77MP0005394_taste/olfaction_phenotype1.01838750
78MP0005499_abnormal_olfactory_system1.01838750
79MP0001697_abnormal_embryo_size1.01836103
80MP0000762_abnormal_tongue_morphology1.01766370
81MP0002085_abnormal_embryonic_tissue1.01540678
82MP0000432_abnormal_head_morphology1.00986145
83MP0009672_abnormal_birth_weight1.00405219
84MP0005197_abnormal_uvea_morphology1.00129967
85MP0002086_abnormal_extraembryonic_tissu0.99748538
86MP0000566_synostosis0.99555590
87MP0000462_abnormal_digestive_system0.98969954
88MP0003123_paternal_imprinting0.98635403
89MP0002282_abnormal_trachea_morphology0.98222454
90MP0002932_abnormal_joint_morphology0.98199247
91MP0008058_abnormal_DNA_repair0.98091712
92MP0002102_abnormal_ear_morphology0.97851096
93MP0003315_abnormal_perineum_morphology0.97721179
94MP0002249_abnormal_larynx_morphology0.97448784
95MP0003880_abnormal_central_pattern0.96845171
96MP0000609_abnormal_liver_physiology0.96381936
97MP0001661_extended_life_span0.95368164
98MP0003942_abnormal_urinary_system0.95166967
99MP0002092_abnormal_eye_morphology0.93201454
100MP0004133_heterotaxia0.92998533
101MP0001666_abnormal_nutrient_absorption0.92993768
102MP0003122_maternal_imprinting0.92476948
103MP0002254_reproductive_system_inflammat0.91724031
104MP0004957_abnormal_blastocyst_morpholog0.91086016
105MP0001849_ear_inflammation0.91068396
106MP0004264_abnormal_extraembryonic_tissu0.90802438
107MP0003935_abnormal_craniofacial_develop0.90412216
108MP0003693_abnormal_embryo_hatching0.90131704
109MP0002697_abnormal_eye_size0.89781040
110MP0005023_abnormal_wound_healing0.89764463
111MP0000579_abnormal_nail_morphology0.89717969
112MP0003453_abnormal_keratinocyte_physiol0.88300423
113MP0000639_abnormal_adrenal_gland0.88115797
114MP0005391_vision/eye_phenotype0.87190727
115MP0000428_abnormal_craniofacial_morphol0.87019908
116MP0005666_abnormal_adipose_tissue0.86877067
117MP0002138_abnormal_hepatobiliary_system0.86479425
118MP0003385_abnormal_body_wall0.86309407
119MP0002118_abnormal_lipid_homeostasis0.85517574
120MP0008789_abnormal_olfactory_epithelium0.85217575
121MP0002128_abnormal_blood_circulation0.84590351
122MP0003861_abnormal_nervous_system0.84243713
123MP0005248_abnormal_Harderian_gland0.84237875
124MP0010352_gastrointestinal_tract_polyps0.83705321
125MP0000377_abnormal_hair_follicle0.82955812
126MP0005253_abnormal_eye_physiology0.82854996
127MP0001293_anophthalmia0.82402668
128MP0000647_abnormal_sebaceous_gland0.82281464
129MP0002098_abnormal_vibrissa_morphology0.82200161
130MP0004145_abnormal_muscle_electrophysio0.81991970
131MP0009250_abnormal_appendicular_skeleto0.81859294
132MP0003283_abnormal_digestive_organ0.81395852
133MP0003566_abnormal_cell_adhesion0.81267064
134MP0000534_abnormal_ureter_morphology0.80718103
135MP0005647_abnormal_sex_gland0.80363505
136MP0000767_abnormal_smooth_muscle0.80077199
137MP0002925_abnormal_cardiovascular_devel0.79712191
138MP0002111_abnormal_tail_morphology0.79507568
139MP0010630_abnormal_cardiac_muscle0.78972776
140* MP0000598_abnormal_liver_morphology0.78945140
141MP0009703_decreased_birth_body0.78930235
142MP0004084_abnormal_cardiac_muscle0.78578157
143MP0003699_abnormal_female_reproductive0.78310253
144MP0003755_abnormal_palate_morphology0.77221617
145MP0004233_abnormal_muscle_weight0.77007766
146MP0003111_abnormal_nucleus_morphology0.76986463
147MP0002109_abnormal_limb_morphology0.76850733
148MP0000569_abnormal_digit_pigmentation0.76440087
149MP0003943_abnormal_hepatobiliary_system0.76263632
150MP0000427_abnormal_hair_cycle0.76153406
151MP0004085_abnormal_heartbeat0.75823157
152MP0002184_abnormal_innervation0.75018323
153MP0002116_abnormal_craniofacial_bone0.74325040

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.69960145
2Intrahepatic cholestasis (HP:0001406)5.40647516
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.25171504
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.77988545
5Xanthomatosis (HP:0000991)3.67618851
6Hypobetalipoproteinemia (HP:0003563)3.63277604
7Hyperlipoproteinemia (HP:0010980)2.98122485
8Epidermoid cyst (HP:0200040)2.96289481
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.93751056
10Degeneration of the lateral corticospinal tracts (HP:0002314)2.93751056
11Hypoglycemic coma (HP:0001325)2.87686605
12Abnormality of methionine metabolism (HP:0010901)2.82986064
13Hypolipoproteinemia (HP:0010981)2.82765299
14Prolonged partial thromboplastin time (HP:0003645)2.79511186
15Pancreatic islet-cell hyperplasia (HP:0004510)2.78932044
16Abnormality of the fetal cardiovascular system (HP:0010948)2.78465271
17Abnormal umbilical cord blood vessels (HP:0011403)2.78465271
18Single umbilical artery (HP:0001195)2.78465271
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.76267452
20Cortical dysplasia (HP:0002539)2.74976454
21Abnormality of the common coagulation pathway (HP:0010990)2.73500052
22Hepatocellular carcinoma (HP:0001402)2.72945435
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.70064659
24Chromsome breakage (HP:0040012)2.67772865
25Spastic diplegia (HP:0001264)2.66508370
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62826485
27Abnormal lung lobation (HP:0002101)2.61174758
28Hypochromic microcytic anemia (HP:0004840)2.56889423
29Fat malabsorption (HP:0002630)2.52179208
30Coronal craniosynostosis (HP:0004440)2.50718882
31Hypoalphalipoproteinemia (HP:0003233)2.50155743
32Myelomeningocele (HP:0002475)2.45906103
33Back pain (HP:0003418)2.44342669
34Complement deficiency (HP:0004431)2.41676679
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.39818787
36Abnormality of chromosome stability (HP:0003220)2.38009174
37Insidious onset (HP:0003587)2.36659509
38Termporal pattern (HP:0011008)2.36659509
39Hypoplastic pelvis (HP:0008839)2.36621327
40Abnormality of the ischium (HP:0003174)2.35878896
41Bifid tongue (HP:0010297)2.32569131
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.32028288
43Esophageal varix (HP:0002040)2.29993215
44Meckel diverticulum (HP:0002245)2.29044135
45Hyperammonemia (HP:0001987)2.25476373
46Shallow orbits (HP:0000586)2.21394803
47Double outlet right ventricle (HP:0001719)2.21015006
48Congenital malformation of the right heart (HP:0011723)2.21015006
49Short 4th metacarpal (HP:0010044)2.20514173
50Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20514173
51Abnormal pancreas size (HP:0012094)2.15758273
52Abnormality of the ileum (HP:0001549)2.15217167
53Septo-optic dysplasia (HP:0100842)2.13628168
54Abnormality of the 4th metacarpal (HP:0010012)2.13562228
55Ketosis (HP:0001946)2.12814453
56Abnormality of glycine metabolism (HP:0010895)2.12016873
57Abnormality of serine family amino acid metabolism (HP:0010894)2.12016873
58Embryonal renal neoplasm (HP:0011794)2.11499182
59Abnormality of the umbilical cord (HP:0010881)2.08820312
60Abnormality of the intrinsic pathway (HP:0010989)2.08812769
61Oligodactyly (hands) (HP:0001180)2.08067258
62Short tibia (HP:0005736)2.06426965
63Abnormality of the pancreatic islet cells (HP:0006476)2.05464213
64Abnormality of endocrine pancreas physiology (HP:0012093)2.05464213
65Steatorrhea (HP:0002570)2.05271558
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.02678703
67Papillary thyroid carcinoma (HP:0002895)2.00054663
68Missing ribs (HP:0000921)1.99661711
69Joint hemorrhage (HP:0005261)1.98882555
70Turricephaly (HP:0000262)1.98616912
71Enlarged kidneys (HP:0000105)1.98582141
72Increased nuchal translucency (HP:0010880)1.98447396
73Hyperglycinemia (HP:0002154)1.96142750
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95877418
75Diastasis recti (HP:0001540)1.95436464
76Ulnar bowing (HP:0003031)1.94587123
77Rhabdomyosarcoma (HP:0002859)1.90333072
78Abnormality of pyrimidine metabolism (HP:0004353)1.86305506
79Acanthocytosis (HP:0001927)1.86107365
80Exercise-induced muscle cramps (HP:0003710)1.85571400
81Anophthalmia (HP:0000528)1.85395461
82Hypercholesterolemia (HP:0003124)1.83665872
83Abnormality of the phalanges of the 2nd finger (HP:0009541)1.78519758
84Glomerulosclerosis (HP:0000096)1.78458077
85Intestinal atresia (HP:0011100)1.78090099
86Cardiovascular calcification (HP:0011915)1.77815213
87Aplasia/hypoplasia of the humerus (HP:0006507)1.76843854
88Abnormality of the corticospinal tract (HP:0002492)1.76691033
89Focal segmental glomerulosclerosis (HP:0000097)1.76213321
90Increased mean platelet volume (HP:0011877)1.75648294
91Short humerus (HP:0005792)1.75123793
92Abnormality of the duodenum (HP:0002246)1.75038994
93Hyporeflexia of lower limbs (HP:0002600)1.74756154
94Absent septum pellucidum (HP:0001331)1.74737734
95Renal hypoplasia (HP:0000089)1.74717753
96Microglossia (HP:0000171)1.74146664
97Abnormality of the labia minora (HP:0012880)1.73973515
98Delayed gross motor development (HP:0002194)1.72631217
99Increased serum pyruvate (HP:0003542)1.72402508
100Hypoglycemic seizures (HP:0002173)1.72326823
101Conjunctival telangiectasia (HP:0000524)1.72284433
102Hematochezia (HP:0002573)1.72265654
103Vascular calcification (HP:0004934)1.71891206
104Hypoplasia of the fovea (HP:0007750)1.70944909
105Aplasia/Hypoplasia of the fovea (HP:0008060)1.70944909
106Duodenal stenosis (HP:0100867)1.70422693
107Small intestinal stenosis (HP:0012848)1.70422693
108Abnormality of fatty-acid metabolism (HP:0004359)1.69868426
109Lymphangioma (HP:0100764)1.69721648
110Pseudobulbar signs (HP:0002200)1.68968531
111Absent radius (HP:0003974)1.68896529
112Clitoromegaly (HP:0000057)1.68215628
113Abnormal gallbladder physiology (HP:0012438)1.67031779
114Cholecystitis (HP:0001082)1.67031779
115Premature rupture of membranes (HP:0001788)1.66697792
116Hyperglycinuria (HP:0003108)1.65992307
117Abnormalities of placenta or umbilical cord (HP:0001194)1.64608883
118Asymmetry of the thorax (HP:0001555)1.64346506
119Methylmalonic acidemia (HP:0002912)1.63986894
120Abnormality of the septum pellucidum (HP:0007375)1.63941606
121Bifid scrotum (HP:0000048)1.63180803
122Sensory axonal neuropathy (HP:0003390)1.62501194
123Infantile muscular hypotonia (HP:0008947)1.62461697
124Abnormality of glutamine family amino acid metabolism (HP:0010902)1.62211951
125Arterial tortuosity (HP:0005116)1.61918585
126Mitral valve prolapse (HP:0001634)1.61625220
127Abnormal auditory evoked potentials (HP:0006958)1.61560638
128Absent forearm bone (HP:0003953)1.61173700
129Aplasia involving forearm bones (HP:0009822)1.61173700
130Hyperbilirubinemia (HP:0002904)1.61088824
131Adrenal hypoplasia (HP:0000835)1.60982398
132Abnormal gallbladder morphology (HP:0012437)1.60953038
133Protrusio acetabuli (HP:0003179)1.60711560
134Disproportionate short-trunk short stature (HP:0003521)1.60211308
135Preaxial foot polydactyly (HP:0001841)1.59989545
136Cutaneous finger syndactyly (HP:0010554)1.59608510
137Abnormality of the fovea (HP:0000493)1.59288058
138Colon cancer (HP:0003003)1.59159528
139Pulmonic stenosis (HP:0001642)1.58998943
140Drooling (HP:0002307)1.58992528
141Hypophosphatemic rickets (HP:0004912)1.58319734
142Volvulus (HP:0002580)1.58021920
143Deviation of the thumb (HP:0009603)1.57869962
144Triphalangeal thumb (HP:0001199)1.57728805
145Hemorrhage of the eye (HP:0011885)1.57645280
146Visceral angiomatosis (HP:0100761)1.57237885
147Ankyloglossia (HP:0010296)1.57043155
148Hyperglycemia (HP:0003074)1.56859755
149Sex reversal (HP:0012245)1.56717455
150Abnormal sex determination (HP:0012244)1.56717455
151Hypoplastic labia majora (HP:0000059)1.56487022
152Neoplasm of the liver (HP:0002896)1.55452413
153Skull defect (HP:0001362)1.54792299
154Abnormality of glycolysis (HP:0004366)1.54738519
155Hemangiomatosis (HP:0007461)1.54648325
156Proximal placement of thumb (HP:0009623)1.54517178
157Scapular winging (HP:0003691)1.54395162
158Myocardial infarction (HP:0001658)1.54334208
159Genital tract atresia (HP:0001827)1.53635335
160Abnormality of the carotid arteries (HP:0005344)1.52585982
161Abnormality of the preputium (HP:0100587)1.52490822
162Abnormality of complement system (HP:0005339)1.51451362
163Nephroblastoma (Wilms tumor) (HP:0002667)1.51210649
164Wide anterior fontanel (HP:0000260)1.50963697
165Hyperinsulinemic hypoglycemia (HP:0000825)1.50402942
166Peritonitis (HP:0002586)1.49967410
167Oligodactyly (HP:0012165)1.49761453
168Gonadotropin excess (HP:0000837)1.49527626
169Patchy hypopigmentation of hair (HP:0011365)1.49299334
170Vaginal atresia (HP:0000148)1.48467890
171Limited hip movement (HP:0008800)1.48191308
172Abnormality of the astrocytes (HP:0100707)1.47914947
173Astrocytoma (HP:0009592)1.47914947
174Glioma (HP:0009733)1.47697109
175Gonadal dysgenesis (HP:0000133)1.46798669
176Short hallux (HP:0010109)1.46738031
177Supernumerary spleens (HP:0009799)1.46697307
178Vertebral clefting (HP:0008428)1.46004740
179Hypoplastic female external genitalia (HP:0012815)1.45869340
180Scrotal hypoplasia (HP:0000046)1.45625956
181Labial hypoplasia (HP:0000066)1.45246410
182Vascular tortuosity (HP:0004948)1.45232508
183White forelock (HP:0002211)1.44743621
184Abnormal vertebral ossification (HP:0100569)1.44490438
185Postnatal microcephaly (HP:0005484)1.43708574
186Aplasia/Hypoplasia of the sternum (HP:0006714)1.43044229
187Neoplasm of the oral cavity (HP:0100649)1.42975216
188Small hand (HP:0200055)1.41907658
189Patent foramen ovale (HP:0001655)1.40302847
190Thyroid carcinoma (HP:0002890)1.40158361
191Cutaneous syndactyly (HP:0012725)1.38894424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.36039009
2LATS13.20988391
3TRIM282.96556131
4TNIK2.86474409
5CDC72.84919938
6FGFR22.78615465
7MKNK22.60702117
8PNCK2.51305003
9TTK2.46609074
10EIF2AK32.38422187
11TIE12.25024705
12MET2.22602102
13ERBB32.06206095
14EPHB12.01218232
15PLK31.99236133
16WNK31.98158719
17EIF2AK11.96723313
18PLK21.94257260
19BUB11.82452378
20STK31.81359244
21TAOK31.80835219
22CASK1.78292618
23ERBB41.77947759
24BCKDK1.74215405
25MELK1.72044494
26PLK41.71959518
27PRKD31.64215555
28OXSR11.63626103
29TSSK61.60551930
30PKN21.57300469
31WNK41.53497511
32BCR1.50133540
33MST41.48253791
34CSNK1G11.47633890
35TRIB31.46521754
36PTK61.42590883
37CSNK1A1L1.40477933
38TAF11.38716852
39SIK11.38100553
40TGFBR11.36065942
41CDK121.32201351
42CSNK1G31.32046935
43FGFR41.29828932
44TTN1.29204132
45PDGFRA1.28476088
46MKNK11.22063769
47CDK61.21573096
48MAP3K61.19224489
49TRPM71.18782081
50MOS1.17659859
51SRPK11.11791759
52EEF2K1.10531897
53BRSK11.09109685
54NEK21.08039753
55FRK1.05260643
56AKT31.04447217
57NEK91.02899418
58TYRO31.02714084
59KDR1.02490061
60PINK11.02366244
61ICK1.00537255
62BRSK20.99167221
63EIF2AK20.97576951
64MTOR0.94525501
65PDK20.92467803
66MAPK130.92374010
67CSNK1G20.92206850
68STK38L0.92013631
69PBK0.91427875
70LIMK10.91282174
71LATS20.89652424
72RPS6KB20.89025437
73STK40.86407420
74DMPK0.85857187
75CHEK20.85619449
76AURKB0.84642653
77YES10.83788346
78PAK20.83630309
79ACVR1B0.82954738
80FGFR10.82816315
81PDGFRB0.80937343
82CDK90.80904190
83KSR10.80846944
84WNK10.79397658
85MAP3K120.78003144
86MARK10.77261413
87CSNK1D0.75644068
88SIK30.75520733
89PLK10.75014381
90MINK10.74720181
91* MAP3K80.74232557
92BRD40.74069908
93PKN10.73089542
94CDK40.72229972
95MAP3K40.71796184
96OBSCN0.71622096
97RET0.70947281
98TESK20.69233894
99CCNB10.68497347
100ATM0.66981360
101PTK20.66394231
102WEE10.66193113
103CHEK10.65985071
104EPHA40.64823414
105SCYL20.64735165
106MAP4K20.63975663
107EPHB20.63171799
108GSK3A0.60440147
109PRKD10.60114120
110CDK70.59775146
111MAP3K100.59249406
112TGFBR20.59074367
113PRKCE0.58021007
114PASK0.55183426
115PIK3CA0.54714844
116PRKAA20.54581640
117CLK10.53591171
118FER0.52387163
119NEK10.51661354
120NTRK10.51520240
121CDK10.49149609
122MAPKAPK50.47814718
123DDR20.47013653
124CAMK1D0.46805371
125EPHA30.45471839
126NUAK10.45362308
127ERBB20.44235890
128MAP2K30.44062250
129NLK0.43659045
130MAP3K30.42972759
131TLK10.42455375
132BMX0.42222330
133CDK20.41655988
134ITK0.41497273
135RPS6KA50.41442828
136CSNK1E0.40783102
137PAK30.40159309
138BMPR1B0.40119487
139MUSK0.40009788
140* ROCK20.39430738
141VRK10.39204457
142PHKG20.39132230
143PHKG10.39132230
144FLT30.38982288
145PRKCG0.37911761
146CAMK2D0.34163202
147* ROCK10.33921139
148CAMK1G0.32609954
149PRKDC0.32554982
150CAMK2A0.32328539
151ILK0.30872351

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.51169135
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.16272714
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71597808
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67006726
5Protein export_Homo sapiens_hsa030602.61268444
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49260832
7Steroid biosynthesis_Homo sapiens_hsa001002.33770970
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21662335
9Fatty acid degradation_Homo sapiens_hsa000712.18806667
10Complement and coagulation cascades_Homo sapiens_hsa046102.13216698
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13120889
12Propanoate metabolism_Homo sapiens_hsa006402.07132735
13Arginine biosynthesis_Homo sapiens_hsa002202.05736288
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.05734973
15Fatty acid elongation_Homo sapiens_hsa000622.05018222
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98287242
17Tryptophan metabolism_Homo sapiens_hsa003801.92832474
18Fatty acid metabolism_Homo sapiens_hsa012121.88658623
19Butanoate metabolism_Homo sapiens_hsa006501.84789979
20Proteasome_Homo sapiens_hsa030501.84741498
21Fanconi anemia pathway_Homo sapiens_hsa034601.83111627
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66316739
23Peroxisome_Homo sapiens_hsa041461.65658635
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63997482
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61427518
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.56971809
27Selenocompound metabolism_Homo sapiens_hsa004501.55670146
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55172413
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55040420
30Histidine metabolism_Homo sapiens_hsa003401.52702748
31One carbon pool by folate_Homo sapiens_hsa006701.46392817
32Sulfur metabolism_Homo sapiens_hsa009201.42966875
33PPAR signaling pathway_Homo sapiens_hsa033201.41399183
34Homologous recombination_Homo sapiens_hsa034401.38731503
35Lysine degradation_Homo sapiens_hsa003101.37720360
36Retinol metabolism_Homo sapiens_hsa008301.28807347
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27676536
38Chemical carcinogenesis_Homo sapiens_hsa052041.26234330
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.25045486
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23283185
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22867467
42Pyruvate metabolism_Homo sapiens_hsa006201.21300310
43Cell cycle_Homo sapiens_hsa041101.21075307
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17064096
45beta-Alanine metabolism_Homo sapiens_hsa004101.16805359
46Wnt signaling pathway_Homo sapiens_hsa043101.14614450
47Arginine and proline metabolism_Homo sapiens_hsa003301.13276735
48Caffeine metabolism_Homo sapiens_hsa002321.12457059
49Tyrosine metabolism_Homo sapiens_hsa003501.12234649
50Nucleotide excision repair_Homo sapiens_hsa034201.08946930
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07059697
52Oocyte meiosis_Homo sapiens_hsa041141.05911886
53Systemic lupus erythematosus_Homo sapiens_hsa053221.04175042
54Folate biosynthesis_Homo sapiens_hsa007901.03764746
55Biosynthesis of amino acids_Homo sapiens_hsa012301.02788092
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.00667966
57Ovarian steroidogenesis_Homo sapiens_hsa049130.95889573
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94876539
59TGF-beta signaling pathway_Homo sapiens_hsa043500.94356392
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94169436
61Fatty acid biosynthesis_Homo sapiens_hsa000610.88971262
62Bile secretion_Homo sapiens_hsa049760.86458668
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85999384
64Ether lipid metabolism_Homo sapiens_hsa005650.85797512
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84415831
66Carbon metabolism_Homo sapiens_hsa012000.83033509
67Glutathione metabolism_Homo sapiens_hsa004800.82631988
68Linoleic acid metabolism_Homo sapiens_hsa005910.79877591
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79291220
70Vitamin B6 metabolism_Homo sapiens_hsa007500.78338704
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77156181
72ECM-receptor interaction_Homo sapiens_hsa045120.76503076
73Circadian rhythm_Homo sapiens_hsa047100.75939448
74Staphylococcus aureus infection_Homo sapiens_hsa051500.75802188
75Phenylalanine metabolism_Homo sapiens_hsa003600.75613100
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72634617
77Adherens junction_Homo sapiens_hsa045200.72537392
78Hippo signaling pathway_Homo sapiens_hsa043900.72386999
79* MicroRNAs in cancer_Homo sapiens_hsa052060.71697653
80Starch and sucrose metabolism_Homo sapiens_hsa005000.68580125
81Tight junction_Homo sapiens_hsa045300.65944726
82RNA polymerase_Homo sapiens_hsa030200.64280952
83Axon guidance_Homo sapiens_hsa043600.63177388
84Small cell lung cancer_Homo sapiens_hsa052220.62714889
85Dilated cardiomyopathy_Homo sapiens_hsa054140.62710877
86ABC transporters_Homo sapiens_hsa020100.61910304
87Basal cell carcinoma_Homo sapiens_hsa052170.61243329
88DNA replication_Homo sapiens_hsa030300.60839345
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60596802
90Fat digestion and absorption_Homo sapiens_hsa049750.59839632
91Non-homologous end-joining_Homo sapiens_hsa034500.57622849
92Spliceosome_Homo sapiens_hsa030400.56572804
93Focal adhesion_Homo sapiens_hsa045100.55435228
94Melanogenesis_Homo sapiens_hsa049160.55315533
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.54226545
96RNA degradation_Homo sapiens_hsa030180.54167212
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53547726
98Renal cell carcinoma_Homo sapiens_hsa052110.49257693
99RNA transport_Homo sapiens_hsa030130.48874874
100Base excision repair_Homo sapiens_hsa034100.46615191
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46285493
102Mismatch repair_Homo sapiens_hsa034300.44518610
103Prostate cancer_Homo sapiens_hsa052150.44127675
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.41993703
105Hedgehog signaling pathway_Homo sapiens_hsa043400.41981485
106Purine metabolism_Homo sapiens_hsa002300.41712292
107N-Glycan biosynthesis_Homo sapiens_hsa005100.41611571
108Vitamin digestion and absorption_Homo sapiens_hsa049770.41603040
109Viral carcinogenesis_Homo sapiens_hsa052030.40792624
110Metabolic pathways_Homo sapiens_hsa011000.39762126
111Insulin resistance_Homo sapiens_hsa049310.38718590
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37811645
113Dorso-ventral axis formation_Homo sapiens_hsa043200.36384181
114AMPK signaling pathway_Homo sapiens_hsa041520.36226938
115Pancreatic cancer_Homo sapiens_hsa052120.35968429
116* Proteoglycans in cancer_Homo sapiens_hsa052050.35313690
117Pathways in cancer_Homo sapiens_hsa052000.34584864
118Melanoma_Homo sapiens_hsa052180.34505033
119Protein digestion and absorption_Homo sapiens_hsa049740.34181531
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34138620
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33071786
122Basal transcription factors_Homo sapiens_hsa030220.32119225
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31842095
124Parkinsons disease_Homo sapiens_hsa050120.31394060
125mRNA surveillance pathway_Homo sapiens_hsa030150.30608061
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30337959
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30283201
128Dopaminergic synapse_Homo sapiens_hsa047280.29907533
129Glycerolipid metabolism_Homo sapiens_hsa005610.29469408
130Circadian entrainment_Homo sapiens_hsa047130.27862905
131p53 signaling pathway_Homo sapiens_hsa041150.27239829
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26875311
133Thyroid hormone synthesis_Homo sapiens_hsa049180.26501155
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26413154

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