REC114

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is orthologous to the mouse meiotic recombination protein REC114, which is involved in DNA double-strand break formation during meiosis. The encoded protein is conserved in most eukaryotes and was first discovered and characterized in yeast. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.67426256
2piRNA metabolic process (GO:0034587)9.44216399
3regulation of meiosis I (GO:0060631)9.05326628
4DNA methylation involved in gamete generation (GO:0043046)7.70367639
5regulation of acrosome reaction (GO:0060046)7.68824441
6aminoglycoside antibiotic metabolic process (GO:0030647)7.30838275
7synapsis (GO:0007129)7.23629282
8female gamete generation (GO:0007292)6.89163622
9maintenance of protein location in nucleus (GO:0051457)6.78793384
10retinal cone cell development (GO:0046549)6.77785288
11regulation of response to osmotic stress (GO:0047484)6.42963506
12protein localization to kinetochore (GO:0034501)6.41907425
13negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.34780543
14oocyte development (GO:0048599)6.34124729
15regulation of mammary gland epithelial cell proliferation (GO:0033599)6.33524859
16regulation of histone H3-K9 methylation (GO:0051570)6.31396948
17somite rostral/caudal axis specification (GO:0032525)6.28365764
18* meiotic cell cycle (GO:0051321)6.27021330
19regulation of nuclear cell cycle DNA replication (GO:0033262)6.26854221
20chromosome organization involved in meiosis (GO:0070192)6.25279595
21synaptonemal complex assembly (GO:0007130)6.24091623
22multicellular organism reproduction (GO:0032504)6.13972684
23positive regulation of mitotic sister chromatid separation (GO:1901970)6.06762333
24positive regulation of mitotic metaphase/anaphase transition (GO:0045842)6.06762333
25positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)6.06762333
26regulation of telomere maintenance via telomerase (GO:0032210)6.06544868
27negative regulation of epidermis development (GO:0045683)5.95296045
28positive regulation of histone H3-K4 methylation (GO:0051571)5.92381950
29negative regulation of telomerase activity (GO:0051974)5.78800722
30negative regulation of cell cycle G2/M phase transition (GO:1902750)5.70686976
31male meiosis I (GO:0007141)5.67216596
32synaptonemal complex organization (GO:0070193)5.64508421
33histone H4-K12 acetylation (GO:0043983)5.57221938
34gene silencing by RNA (GO:0031047)5.55434243
35negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.54804834
36histone H4-K8 acetylation (GO:0043982)5.54424883
37histone H4-K5 acetylation (GO:0043981)5.54424883
38regulation of MHC class I biosynthetic process (GO:0045343)5.51368095
39regulation of steroid hormone secretion (GO:2000831)5.49878244
40male meiosis (GO:0007140)5.42468399
41mitotic sister chromatid segregation (GO:0000070)5.41492138
42centriole replication (GO:0007099)5.40082790
43rRNA transcription (GO:0009303)5.39271075
44negative regulation of reproductive process (GO:2000242)5.35004677
45regulation of cell maturation (GO:1903429)5.26089755
46muscle organ morphogenesis (GO:0048644)5.19675540
47negative regulation of histone methylation (GO:0031061)5.00573098
48protein localization to chromosome, centromeric region (GO:0071459)4.92914740
49meiotic nuclear division (GO:0007126)4.90882775
50positive regulation of chromosome segregation (GO:0051984)4.89377913
51positive regulation of gastrulation (GO:2000543)4.83981865
52positive regulation of DNA-dependent DNA replication (GO:2000105)4.80095450
53DNA replication-dependent nucleosome organization (GO:0034723)4.76940007
54DNA replication-dependent nucleosome assembly (GO:0006335)4.76940007
55rRNA methylation (GO:0031167)4.76568225
56cytidine deamination (GO:0009972)4.69400660
57cytidine metabolic process (GO:0046087)4.69400660
58cytidine catabolic process (GO:0006216)4.69400660
59negative regulation of epidermal cell differentiation (GO:0045605)4.68949895
60notochord development (GO:0030903)4.68632878
61meiosis I (GO:0007127)4.61621081
62establishment of chromosome localization (GO:0051303)4.60880227
63regulation of cilium movement (GO:0003352)4.59988854
64negative regulation of telomere maintenance (GO:0032205)4.59258258
65mitotic metaphase plate congression (GO:0007080)4.58490585
66meiotic cell cycle process (GO:1903046)4.52115880
67DNA replication checkpoint (GO:0000076)4.52021116
68heterochromatin organization (GO:0070828)4.51741083
69positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.51219592
70rRNA modification (GO:0000154)4.49945434
71protein kinase C signaling (GO:0070528)4.48642595
72sister chromatid segregation (GO:0000819)4.47241921
73quinone metabolic process (GO:1901661)4.44262853
74glycine transport (GO:0015816)4.44026799
75response to dietary excess (GO:0002021)4.43145050
76regulation of meiosis (GO:0040020)4.42906714
77regulation of translation in response to stress (GO:0043555)4.41140937
78hormone catabolic process (GO:0042447)4.37979213
79coenzyme catabolic process (GO:0009109)4.37184664
80chromatin assembly (GO:0031497)4.34220156
81nucleoside transmembrane transport (GO:1901642)4.34212517
82regulation of apoptotic process involved in morphogenesis (GO:1902337)4.32526723
83phenol-containing compound catabolic process (GO:0019336)4.31581501
84oogenesis (GO:0048477)4.27578775
85protein localization to chromosome (GO:0034502)4.26149761
86primitive streak formation (GO:0090009)4.20607214
87interferon-gamma production (GO:0032609)4.18659906
88nuclear pore complex assembly (GO:0051292)4.14713536
89positive regulation of humoral immune response (GO:0002922)4.12035152
90histone H4-K16 acetylation (GO:0043984)4.08181874
91reproduction (GO:0000003)4.02650010
92DNA methylation (GO:0006306)3.99990562
93DNA alkylation (GO:0006305)3.99990562
94branching involved in mammary gland duct morphogenesis (GO:0060444)3.99351810
95fertilization (GO:0009566)3.97826235
96cell fate commitment involved in formation of primary germ layer (GO:0060795)3.93325083
97regulation of meiotic cell cycle (GO:0051445)3.91318431
98nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.90785746
99metaphase plate congression (GO:0051310)3.89588606
100cullin deneddylation (GO:0010388)3.85196680
101relaxation of smooth muscle (GO:0044557)3.84715329
102centriole assembly (GO:0098534)3.83193522
103positive regulation of histone methylation (GO:0031062)3.80992580
104binding of sperm to zona pellucida (GO:0007339)3.78870845
105maintenance of protein localization in organelle (GO:0072595)3.73754507
106attachment of spindle microtubules to kinetochore (GO:0008608)3.73252368
107genitalia morphogenesis (GO:0035112)3.70157367
108CENP-A containing nucleosome assembly (GO:0034080)3.69657670
109nuclear pore organization (GO:0006999)3.69250202
110negative regulation of cAMP-mediated signaling (GO:0043951)3.69207030
111cellular modified amino acid catabolic process (GO:0042219)3.66934261
112intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.66753634
113intestinal epithelial cell development (GO:0060576)3.61952018
114regulation of telomerase activity (GO:0051972)3.61522648
115gene silencing (GO:0016458)3.61478139
116regulation of telomere maintenance (GO:0032204)3.59827971
117labyrinthine layer development (GO:0060711)3.57583229
118regulation of double-strand break repair via homologous recombination (GO:0010569)3.55843180
119mitochondrion distribution (GO:0048311)3.51669827
120ribosome biogenesis (GO:0042254)3.51544994
121sister chromatid cohesion (GO:0007062)3.51202203
122regulation of histone H3-K4 methylation (GO:0051569)3.48795942
123GDP-mannose metabolic process (GO:0019673)3.47601764
124regulation of chromatin silencing (GO:0031935)3.47415558
125pre-miRNA processing (GO:0031054)3.46927618
126positive regulation of protein deacetylation (GO:0090312)3.46681927
127cardiovascular system development (GO:0072358)3.44771414
128negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.44659153
129DNA damage induced protein phosphorylation (GO:0006975)3.43044483
130citrulline biosynthetic process (GO:0019240)3.42725953
131transcription from mitochondrial promoter (GO:0006390)3.39568787
132protein deneddylation (GO:0000338)3.38759795
133neuron fate determination (GO:0048664)3.37516852
134DNA damage response, detection of DNA damage (GO:0042769)3.36610483
135chromatin remodeling at centromere (GO:0031055)3.36472403
136retinoic acid receptor signaling pathway (GO:0048384)3.34539545
137positive regulation of meiosis (GO:0045836)3.33173865
138regulation of spindle checkpoint (GO:0090231)3.32582077
139epoxygenase P450 pathway (GO:0019373)3.31995352
140regulation of steroid hormone biosynthetic process (GO:0090030)3.31937759
141mitotic chromosome condensation (GO:0007076)3.30944261
142regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.28952629
143formation of translation preinitiation complex (GO:0001731)3.24692645
144histone exchange (GO:0043486)3.23512359
145pyrimidine ribonucleoside catabolic process (GO:0046133)3.22912593
146RNA stabilization (GO:0043489)3.22129474
147mRNA stabilization (GO:0048255)3.22129474
148maternal placenta development (GO:0001893)3.20950919
149regulation of histone methylation (GO:0031060)3.20837291
150histone H3-K9 demethylation (GO:0033169)3.18885667
151nucleoside transport (GO:0015858)3.18068928
152apoptotic DNA fragmentation (GO:0006309)3.17227339
153microtubule severing (GO:0051013)3.16800761
154phosphorelay signal transduction system (GO:0000160)3.16675636
155intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.16141376
156pseudouridine synthesis (GO:0001522)3.16038310
157vitamin A metabolic process (GO:0006776)3.14906059
158bone trabecula formation (GO:0060346)3.13453698
159trophectodermal cell differentiation (GO:0001829)3.13327311
160regulation of gene silencing by RNA (GO:0060966)3.13279486
161regulation of posttranscriptional gene silencing (GO:0060147)3.13279486
162regulation of gene silencing by miRNA (GO:0060964)3.13279486
163DNA duplex unwinding (GO:0032508)3.13145006
164regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.12952628
165pore complex assembly (GO:0046931)3.11774272
166translesion synthesis (GO:0019985)3.11711321
167regulation of corticosteroid hormone secretion (GO:2000846)3.11204906
168L-amino acid import (GO:0043092)3.10721363
169DNA geometric change (GO:0032392)3.08954998
170regulation of reproductive process (GO:2000241)3.08810961
171positive regulation of meiotic cell cycle (GO:0051446)3.08210736
172positive regulation of reproductive process (GO:2000243)3.08107684
173interkinetic nuclear migration (GO:0022027)3.07634553
174negative regulation of circadian rhythm (GO:0042754)3.07480732
175DNA replication-independent nucleosome organization (GO:0034724)3.05717433
176DNA replication-independent nucleosome assembly (GO:0006336)3.05717433
177protein polyglutamylation (GO:0018095)3.05105187
178positive regulation of histone deacetylation (GO:0031065)3.04671474
179sperm-egg recognition (GO:0035036)3.01564788
180cofactor transport (GO:0051181)3.00631991
181centrosome duplication (GO:0051298)3.00589106
182single fertilization (GO:0007338)3.00122410
183regulation of spindle organization (GO:0090224)2.99466741
184regulation of DNA-dependent DNA replication (GO:0090329)2.99209999
185regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98905739
186negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.98767917
187regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98651963
188oocyte maturation (GO:0001556)2.98453794
189DNA methylation or demethylation (GO:0044728)2.97753321
190daunorubicin metabolic process (GO:0044597)11.3078072
191polyketide metabolic process (GO:0030638)11.3078072
192doxorubicin metabolic process (GO:0044598)11.3078072
193regulation of DNA methylation (GO:0044030)10.0304391

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.25101158
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.25101158
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.25101158
4BP1_19119308_ChIP-ChIP_Hs578T_Human6.23893871
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.81552799
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.43791732
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.16202040
8E2F7_22180533_ChIP-Seq_HELA_Human4.75391071
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.30050089
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.19552987
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.96935819
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.95545574
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.85640263
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.80802939
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.77259889
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.68158004
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.64899518
18TCF3_18692474_ChIP-Seq_MESCs_Mouse2.46099874
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42853409
20TCF3_18692474_ChIP-Seq_MEFs_Mouse2.38433116
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.36095296
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.36067567
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35207788
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.27059316
25GBX2_23144817_ChIP-Seq_PC3_Human2.17489907
26NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.06450321
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02073194
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.01283056
29EZH2_22144423_ChIP-Seq_EOC_Human12.1287282
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94518415
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.93055867
32IRF1_19129219_ChIP-ChIP_H3396_Human1.90024037
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.89777871
34NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.89762004
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.83627033
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.82249858
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.79694863
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78588457
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77804110
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71523544
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71354785
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70642456
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69912512
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65297746
45POU5F1_16518401_ChIP-PET_MESCs_Mouse1.61095163
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60885826
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60647876
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60578910
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59320111
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58326127
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57361790
52TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.50896960
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47286154
54NANOG_18692474_ChIP-Seq_MEFs_Mouse1.46525423
55NANOG_18692474_ChIP-Seq_MESCs_Mouse1.45092917
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.44412298
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.43813411
58CBP_20019798_ChIP-Seq_JUKART_Human1.43117132
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43117132
60POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.42893897
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.41833600
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41648446
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41064575
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40283075
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40155098
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39322141
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.38803446
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37962913
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35441204
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33687750
71OCT4_18692474_ChIP-Seq_MEFs_Mouse1.32726508
72TCF4_23295773_ChIP-Seq_U87_Human1.31887914
73EWS_26573619_Chip-Seq_HEK293_Human1.30776677
74SOX2_18692474_ChIP-Seq_MESCs_Mouse1.29470233
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28731296
76PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.27665888
77E2F1_17053090_ChIP-ChIP_MCF-7_Human1.27580805
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.27541042
79HTT_18923047_ChIP-ChIP_STHdh_Human1.24090009
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23227456
81AR_25329375_ChIP-Seq_VCAP_Human1.21878206
82SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21539041
83MYC_22102868_ChIP-Seq_BL_Human1.21532748
84SMAD4_21799915_ChIP-Seq_A2780_Human1.18760584
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17972113
86STAT3_23295773_ChIP-Seq_U87_Human1.15105408
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14420158
88NANOG_16518401_ChIP-PET_MESCs_Mouse1.13724069
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11982832
90P300_19829295_ChIP-Seq_ESCs_Human1.11961358
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11682028
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.11393723
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11246982
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10779926
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10779926
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.10195658
97TP53_16413492_ChIP-PET_HCT116_Human1.08670278
98SMAD4_21741376_ChIP-Seq_EPCs_Human1.07712246
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07603637
100NANOG_21062744_ChIP-ChIP_HESCs_Human1.06519223
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06268453
102RUNX2_22187159_ChIP-Seq_PCA_Human1.05843656
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.05130917
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04324181
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02479990
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02118310
107CDX2_20551321_ChIP-Seq_CACO-2_Human1.00833351
108FUS_26573619_Chip-Seq_HEK293_Human0.99664430
109RNF2_27304074_Chip-Seq_NSC_Mouse0.98678264
110E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98377713
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97930289
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.97282121
113NCOR1_26117541_ChIP-Seq_K562_Human0.96100447
114TAF15_26573619_Chip-Seq_HEK293_Human0.96070162
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94944794
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94857610
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94414836
118KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93578205
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93367677
120TP53_22127205_ChIP-Seq_IMR90_Human0.93266222
121CBP_21632823_ChIP-Seq_H3396_Human0.92617012
122SALL4_22934838_ChIP-ChIP_CD34+_Human0.92140242
123SCL_19346495_ChIP-Seq_HPC-7_Human0.91606135
124VDR_22108803_ChIP-Seq_LS180_Human0.91398820
125PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91307837
126NANOG_20526341_ChIP-Seq_ESCs_Human0.90902360
127SMAD_19615063_ChIP-ChIP_OVARY_Human0.89621091
128FOXH1_21741376_ChIP-Seq_EPCs_Human0.89137029
129KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88993112
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88484903
131SMAD3_21741376_ChIP-Seq_EPCs_Human0.88437973
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87831760
133POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87784534
134CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87317599
135BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87152696
136ER_23166858_ChIP-Seq_MCF-7_Human0.86688908
137KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85701770
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85520802
139FOXP3_21729870_ChIP-Seq_TREG_Human0.85257322
140GF1_26923725_Chip-Seq_HPCs_Mouse0.84491735
141ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82981175
142POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82818194
143BCAT_22108803_ChIP-Seq_LS180_Human0.81747889
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81688073
145TCF7_22412390_ChIP-Seq_EML_Mouse0.80548201
146AHR_22903824_ChIP-Seq_MCF-7_Human0.80259676
147KAP1_27257070_Chip-Seq_ESCs_Mouse0.80160541
148TP53_22573176_ChIP-Seq_HFKS_Human0.79976346
149ZNF274_21170338_ChIP-Seq_K562_Hela0.79887304
150JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.79868814
151PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78548707
152CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77544095
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77208909
154TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76549179
155SOX2_16153702_ChIP-ChIP_HESCs_Human0.76498343
156YY1_22570637_ChIP-Seq_MALME-3M_Human0.76383031
157LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75972946
158CDX2_22108803_ChIP-Seq_LS180_Human0.75754322
159OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75591204
160TBX3_20139965_ChIP-Seq_ESCs_Mouse0.75412784
161FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75236994
162FOXA1_25329375_ChIP-Seq_VCAP_Human0.75236994
163KDM5A_27292631_Chip-Seq_BREAST_Human0.74958180
164NANOG_19829295_ChIP-Seq_ESCs_Human0.74942681
165SOX2_19829295_ChIP-Seq_ESCs_Human0.74942681
166SMRT_27268052_Chip-Seq_Bcells_Human0.74872281
167NELFA_20434984_ChIP-Seq_ESCs_Mouse0.74746511
168TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.74395868
169TBX3_20139965_ChIP-Seq_MESCs_Mouse0.74082951
170ETS1_20019798_ChIP-Seq_JURKAT_Human0.73880019
171XRN2_22483619_ChIP-Seq_HELA_Human0.72542264
172SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72234323
173CTCF_21964334_Chip-Seq_Bcells_Human0.70566731
174AR_21909140_ChIP-Seq_LNCAP_Human0.70487354
175ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70005024
176SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.69279019
177PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68598255
178MYCN_18555785_ChIP-Seq_MESCs_Mouse0.68022258
179SRY_22984422_ChIP-ChIP_TESTIS_Rat0.67256440
180ELF1_20517297_ChIP-Seq_JURKAT_Human0.66371818
181SMC4_20622854_ChIP-Seq_HELA_Human0.65776285
182KDM2B_26808549_Chip-Seq_SUP-B15_Human0.64406166
183STAT3_18555785_ChIP-Seq_MESCs_Mouse0.63821326
184ELK3_25401928_ChIP-Seq_HUVEC_Human0.62541272

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.29700734
2MP0008877_abnormal_DNA_methylation6.02032684
3MP0003011_delayed_dark_adaptation4.67484355
4MP0004264_abnormal_extraembryonic_tissu4.46680266
5MP0002254_reproductive_system_inflammat4.44986686
6MP0006292_abnormal_olfactory_placode4.34060366
7MP0003890_abnormal_embryonic-extraembry3.56034803
8MP0002139_abnormal_hepatobiliary_system3.36896269
9MP0008057_abnormal_DNA_replication3.35817716
10MP0005075_abnormal_melanosome_morpholog3.32227242
11MP0005499_abnormal_olfactory_system3.26386421
12MP0005394_taste/olfaction_phenotype3.26386421
13MP0005395_other_phenotype3.24725216
14MP0004957_abnormal_blastocyst_morpholog3.04583626
15MP0004858_abnormal_nervous_system2.89754326
16MP0003122_maternal_imprinting2.88042482
17MP0002332_abnormal_exercise_endurance2.86684022
18MP0002138_abnormal_hepatobiliary_system2.75351917
19MP0010234_abnormal_vibrissa_follicle2.65737796
20MP0002210_abnormal_sex_determination2.56698969
21MP0001929_abnormal_gametogenesis2.56007742
22MP0003699_abnormal_female_reproductive2.54906460
23MP0006035_abnormal_mitochondrial_morpho2.46775937
24MP0002234_abnormal_pharynx_morphology2.39743592
25MP0005257_abnormal_intraocular_pressure2.37843467
26MP0008058_abnormal_DNA_repair2.33571147
27MP0003705_abnormal_hypodermis_morpholog2.33320808
28MP0003121_genomic_imprinting2.33243622
29MP0005360_urolithiasis2.30274304
30MP0002653_abnormal_ependyma_morphology2.25590373
31MP0010352_gastrointestinal_tract_polyps2.16187063
32MP0005410_abnormal_fertilization2.13369768
33MP0000653_abnormal_sex_gland1.99850086
34MP0000678_abnormal_parathyroid_gland1.96479073
35MP0005380_embryogenesis_phenotype1.94203418
36MP0001672_abnormal_embryogenesis/_devel1.94203418
37MP0003950_abnormal_plasma_membrane1.86430742
38MP0002160_abnormal_reproductive_system1.82124519
39MP0002088_abnormal_embryonic_growth/wei1.80040464
40MP0002161_abnormal_fertility/fecundity1.79933375
41MP0003984_embryonic_growth_retardation1.78569641
42MP0003938_abnormal_ear_development1.75762631
43MP0003879_abnormal_hair_cell1.74853988
44MP0003077_abnormal_cell_cycle1.70500090
45MP0001145_abnormal_male_reproductive1.68192956
46MP0002127_abnormal_cardiovascular_syste1.65240199
47MP0001984_abnormal_olfaction1.64686910
48MP0001293_anophthalmia1.63977646
49MP0008961_abnormal_basal_metabolism1.60101919
50MP0003111_abnormal_nucleus_morphology1.59557110
51MP0000350_abnormal_cell_proliferation1.58191305
52MP0003123_paternal_imprinting1.57955535
53MP0003183_abnormal_peptide_metabolism1.55999753
54MP0002277_abnormal_respiratory_mucosa1.55615573
55MP0003698_abnormal_male_reproductive1.52488227
56MP0001119_abnormal_female_reproductive1.51536408
57MP0001849_ear_inflammation1.49797826
58MP0002092_abnormal_eye_morphology1.41481958
59MP0005266_abnormal_metabolism1.40234899
60MP0002086_abnormal_extraembryonic_tissu1.39432347
61MP0010030_abnormal_orbit_morphology1.38421329
62MP0005647_abnormal_sex_gland1.37737093
63MP0010307_abnormal_tumor_latency1.36822696
64MP0006082_CNS_inflammation1.36281369
65MP0010094_abnormal_chromosome_stability1.36122498
66MP0008789_abnormal_olfactory_epithelium1.33931998
67MP0002932_abnormal_joint_morphology1.32792496
68MP0002085_abnormal_embryonic_tissue1.30102447
69MP0000049_abnormal_middle_ear1.29055316
70MP0002396_abnormal_hematopoietic_system1.28584521
71MP0005389_reproductive_system_phenotype1.25435997
72MP0003252_abnormal_bile_duct1.24155768
73MP0000762_abnormal_tongue_morphology1.21121556
74MP0000427_abnormal_hair_cycle1.16949466
75MP0002084_abnormal_developmental_patter1.13907019
76MP0004133_heterotaxia1.10768497
77MP0000566_synostosis1.08279708
78MP0002233_abnormal_nose_morphology1.07955051
79MP0000631_abnormal_neuroendocrine_gland1.07557125
80MP0004043_abnormal_pH_regulation1.06934087
81MP0000313_abnormal_cell_death1.05943688
82MP0002132_abnormal_respiratory_system1.04314591
83MP0003119_abnormal_digestive_system1.03813514
84MP0002970_abnormal_white_adipose1.03778099
85MP0004197_abnormal_fetal_growth/weight/1.03375847
86MP0002114_abnormal_axial_skeleton1.02567435
87MP0001730_embryonic_growth_arrest1.02101608
88MP0000490_abnormal_crypts_of1.01082959
89MP0005085_abnormal_gallbladder_physiolo1.00718854
90MP0008932_abnormal_embryonic_tissue1.00485060
91MP0010678_abnormal_skin_adnexa0.99989978
92MP0004381_abnormal_hair_follicle0.98717424
93MP0008770_decreased_survivor_rate0.98211087
94MP0005646_abnormal_pituitary_gland0.97602700
95MP0000432_abnormal_head_morphology0.95225204
96MP0005551_abnormal_eye_electrophysiolog0.94338404
97MP0003315_abnormal_perineum_morphology0.93985339
98MP0001697_abnormal_embryo_size0.93288168
99MP0000428_abnormal_craniofacial_morphol0.93212229
100MP0001348_abnormal_lacrimal_gland0.92455340
101MP0003935_abnormal_craniofacial_develop0.91460109
102MP0005248_abnormal_Harderian_gland0.91331405
103MP0003137_abnormal_impulse_conducting0.90687858
104MP0010368_abnormal_lymphatic_system0.90019832
105MP0002080_prenatal_lethality0.89540223
106MP0003755_abnormal_palate_morphology0.89451045
107MP0003693_abnormal_embryo_hatching0.88203353
108MP0000749_muscle_degeneration0.87572712
109MP0005391_vision/eye_phenotype0.87216198
110MP0003787_abnormal_imprinting0.85972404
111MP0000750_abnormal_muscle_regeneration0.82788228
112MP0008007_abnormal_cellular_replicative0.81347500
113MP0001986_abnormal_taste_sensitivity0.79137686
114MP0002925_abnormal_cardiovascular_devel0.78101632
115MP0002269_muscular_atrophy0.78036642
116MP0000358_abnormal_cell_content/0.77538539
117MP0003283_abnormal_digestive_organ0.76877681
118MP0005508_abnormal_skeleton_morphology0.76435789
119MP0002272_abnormal_nervous_system0.73885307
120MP0002751_abnormal_autonomic_nervous0.72809699
121MP0003786_premature_aging0.72809033
122MP0001666_abnormal_nutrient_absorption0.72535718
123MP0006036_abnormal_mitochondrial_physio0.72435580
124MP0009703_decreased_birth_body0.71387912
125MP0001664_abnormal_digestion0.69255598
126MP0004142_abnormal_muscle_tone0.69190330
127MP0005023_abnormal_wound_healing0.68709515
128MP0003186_abnormal_redox_activity0.65774211
129MP0001324_abnormal_eye_pigmentation0.65518508
130MP0001286_abnormal_eye_development0.65003501
131MP0002638_abnormal_pupillary_reflex0.64760680
132MP0002928_abnormal_bile_duct0.63070720
133MP0002116_abnormal_craniofacial_bone0.62198460
134MP0003868_abnormal_feces_composition0.62013490
135MP0003656_abnormal_erythrocyte_physiolo0.61948764
136MP0002249_abnormal_larynx_morphology0.61031258
137MP0005384_cellular_phenotype0.60792298
138MP0009840_abnormal_foam_cell0.60284565
139MP0003806_abnormal_nucleotide_metabolis0.60212627
140MP0006276_abnormal_autonomic_nervous0.59947600
141MP0003136_yellow_coat_color0.59476284
142MP0003937_abnormal_limbs/digits/tail_de0.59396305
143MP0002098_abnormal_vibrissa_morphology0.58806809
144MP0005319_abnormal_enzyme/_coenzyme0.57866389
145MP0002019_abnormal_tumor_incidence0.57418749
146MP0003941_abnormal_skin_development0.57356004
147MP0008872_abnormal_physiological_respon0.55846840
148MP0002796_impaired_skin_barrier0.53509322
149MP0002090_abnormal_vision0.52734691
150MP0005503_abnormal_tendon_morphology0.49841469
151MP0008995_early_reproductive_senescence0.46942837
152MP0001963_abnormal_hearing_physiology0.45110367
153MP0000015_abnormal_ear_pigmentation0.43228069
154MP0005501_abnormal_skin_physiology0.40214804
155MP0004084_abnormal_cardiac_muscle0.40025338
156MP0001502_abnormal_circadian_rhythm0.39713320
157MP0000383_abnormal_hair_follicle0.38773639
158MP0003195_calcinosis0.38526477
159MP0006072_abnormal_retinal_apoptosis0.36996035
160MP0001919_abnormal_reproductive_system0.34529432
161MP0000377_abnormal_hair_follicle0.32569186
162MP0005174_abnormal_tail_pigmentation0.29772872

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.54793033
2Hypochromic microcytic anemia (HP:0004840)7.15407792
3Facial hemangioma (HP:0000329)5.80908957
4Hepatoblastoma (HP:0002884)5.51487035
5Oligodactyly (hands) (HP:0001180)5.42759499
6Multiple enchondromatosis (HP:0005701)5.34190173
7Abnormality of abdominal situs (HP:0011620)4.87785988
8Abdominal situs inversus (HP:0003363)4.87785988
9Abnormality of the lower motor neuron (HP:0002366)4.85277177
10Rib fusion (HP:0000902)4.66559996
11Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.54400604
12Azoospermia (HP:0000027)4.47009624
13Ependymoma (HP:0002888)4.37080829
14Abnormal gallbladder physiology (HP:0012438)4.33075515
15Cholecystitis (HP:0001082)4.33075515
16Osteomalacia (HP:0002749)4.28487256
17Lip pit (HP:0100267)4.22230927
18Abnormality of the labia minora (HP:0012880)4.07536807
19Wrist flexion contracture (HP:0001239)4.06522540
20Anterior segment dysgenesis (HP:0007700)3.98536829
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.95864093
22Septo-optic dysplasia (HP:0100842)3.89827146
23Gonadotropin excess (HP:0000837)3.88957910
24Nephroblastoma (Wilms tumor) (HP:0002667)3.84827531
25Neoplasm of striated muscle (HP:0009728)3.83421850
26Papillary thyroid carcinoma (HP:0002895)3.79395080
27Enlarged penis (HP:0000040)3.79323020
28Rhabdomyosarcoma (HP:0002859)3.75714717
29Oligodactyly (HP:0012165)3.74265058
30Hypophosphatemic rickets (HP:0004912)3.72949851
31Median cleft lip (HP:0000161)3.69110750
32Absent septum pellucidum (HP:0001331)3.63799902
33Capillary hemangiomas (HP:0005306)3.58532961
34Short tibia (HP:0005736)3.56509781
35Embryonal renal neoplasm (HP:0011794)3.55966371
36Aplasia/Hypoplasia of the fovea (HP:0008060)3.55383761
37Hypoplasia of the fovea (HP:0007750)3.55383761
38Testicular atrophy (HP:0000029)3.44457935
39Fair hair (HP:0002286)3.43333005
40Chromsome breakage (HP:0040012)3.42743368
41Abnormal spermatogenesis (HP:0008669)3.41597900
42Infertility (HP:0000789)3.41154489
43Fused cervical vertebrae (HP:0002949)3.37151173
44Rectovaginal fistula (HP:0000143)3.33780531
45Rectal fistula (HP:0100590)3.33780531
46Aplasia/Hypoplasia of the tibia (HP:0005772)3.32285586
47Abnormality of the septum pellucidum (HP:0007375)3.18592078
48Ragged-red muscle fibers (HP:0003200)3.17638149
49Male infertility (HP:0003251)3.12903977
50Partial duplication of thumb phalanx (HP:0009944)3.10245813
51Abnormality of the astrocytes (HP:0100707)3.07324856
52Astrocytoma (HP:0009592)3.07324856
53Abnormal lung lobation (HP:0002101)3.04544416
54Hyperinsulinemic hypoglycemia (HP:0000825)3.03094772
55Abnormality of the salivary glands (HP:0010286)3.01650253
56Hypochromic anemia (HP:0001931)3.01349220
57Intestinal fistula (HP:0100819)2.98872484
58Amyotrophic lateral sclerosis (HP:0007354)2.97085046
59Malnutrition (HP:0004395)2.95430814
60Bifid tongue (HP:0010297)2.92479698
61Aplasia/hypoplasia of the humerus (HP:0006507)2.92230858
62Vaginal fistula (HP:0004320)2.90043562
63Reduced antithrombin III activity (HP:0001976)2.86674834
64Trismus (HP:0000211)2.86029080
65Abnormal cartilage morphology (HP:0002763)2.82595321
66Stillbirth (HP:0003826)2.81427232
67Short humerus (HP:0005792)2.81052582
68Anomalous pulmonary venous return (HP:0010772)2.76149905
69Ankle contracture (HP:0006466)2.70015658
70Partial duplication of the phalanx of hand (HP:0009999)2.68531014
71Horizontal nystagmus (HP:0000666)2.67033657
72Meckel diverticulum (HP:0002245)2.66659488
73Abnormality of the fovea (HP:0000493)2.66458652
74Urethral obstruction (HP:0000796)2.61412264
75Apathy (HP:0000741)2.58802231
76Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.56460237
77Impulsivity (HP:0100710)2.55576510
78Intrahepatic cholestasis (HP:0001406)2.51715269
79Abnormality of the ileum (HP:0001549)2.51210781
80Preauricular skin tag (HP:0000384)2.50358962
81Shawl scrotum (HP:0000049)2.48202937
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.47213076
83Truncal obesity (HP:0001956)2.45348267
84Generalized hypopigmentation of hair (HP:0011358)2.44499475
85Diminished motivation (HP:0000745)2.43870015
86Progressive muscle weakness (HP:0003323)2.42332024
87Hypokinesia (HP:0002375)2.40507212
88Supernumerary spleens (HP:0009799)2.40386572
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.39717825
90Generalized hypotonia (HP:0001290)2.39409162
91Abnormality of chromosome segregation (HP:0002916)2.39352636
92Large earlobe (HP:0009748)2.38746464
93Tetraplegia (HP:0002445)2.37384542
94Aplasia/Hypoplasia of the macula (HP:0008059)2.35420773
95Bile duct proliferation (HP:0001408)2.35020864
96Abnormal biliary tract physiology (HP:0012439)2.35020864
97Preauricular pit (HP:0004467)2.33982313
98Periauricular skin pits (HP:0100277)2.33982313
99Abnormality of the pulmonary veins (HP:0011718)2.32924123
100Heterotopia (HP:0002282)2.32298216
101Congenital sensorineural hearing impairment (HP:0008527)2.31313287
102Abnormality of chromosome stability (HP:0003220)2.31308901
103Glioma (HP:0009733)2.29410292
104Hyperventilation (HP:0002883)2.26736324
105Short 5th finger (HP:0009237)2.25488167
106Metaphyseal irregularity (HP:0003025)2.25214618
107Lower limb hyperreflexia (HP:0002395)2.24195387
108Sensory axonal neuropathy (HP:0003390)2.22917639
109Bundle branch block (HP:0011710)2.22891304
110Tongue fasciculations (HP:0001308)2.22365789
111Nasolacrimal duct obstruction (HP:0000579)2.22217610
112Skin tags (HP:0010609)2.20218647
113Hip contracture (HP:0003273)2.20067584
114Bicornuate uterus (HP:0000813)2.18195359
115Aplasia/Hypoplasia of the sternum (HP:0006714)2.16902645
116Conjunctival telangiectasia (HP:0000524)2.16072107
117Volvulus (HP:0002580)2.15788410
118Abnormal ciliary motility (HP:0012262)2.15262426
119Villous atrophy (HP:0011473)2.14898726
120Abnormality of small intestinal villus morphology (HP:0011472)2.14898726
121Abnormality of the phalanges of the hallux (HP:0010057)2.14069542
122Small intestinal stenosis (HP:0012848)2.13913097
123Duodenal stenosis (HP:0100867)2.13913097
124Upper motor neuron abnormality (HP:0002127)2.13810389
125Premature ovarian failure (HP:0008209)2.13479142
126Abnormality of the musculature of the hand (HP:0001421)2.11697578
127Thyroid carcinoma (HP:0002890)2.10720366
128Increased connective tissue (HP:0009025)2.10493458
129Maternal diabetes (HP:0009800)2.09744334
130Aplasia/Hypoplasia affecting the retina (HP:0008061)2.09325211
131Tubulointerstitial nephritis (HP:0001970)2.08964475
132Aplasia of the musculature (HP:0100854)2.08152620
133Difficulty running (HP:0009046)2.05658643
134Atrophy/Degeneration involving motor neurons (HP:0007373)2.05409765
135Pseudobulbar signs (HP:0002200)2.05066361
136Absent radius (HP:0003974)2.04339643
137Abnormality of glycolipid metabolism (HP:0010969)2.03977294
138Abnormality of liposaccharide metabolism (HP:0010968)2.03977294
139Abnormality of glycosphingolipid metabolism (HP:0004343)2.03977294
140Malignant neoplasm of the central nervous system (HP:0100836)2.03409952
141Proximal tubulopathy (HP:0000114)2.03358044
142Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.02529205
143Microvesicular hepatic steatosis (HP:0001414)2.02077762
144Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01821841
145Abnormality of the preputium (HP:0100587)2.01255825
146Microretrognathia (HP:0000308)2.00558835
147Muscle fibrillation (HP:0010546)2.00442380
148Pendular nystagmus (HP:0012043)2.00379528
1493-Methylglutaconic aciduria (HP:0003535)2.00309680
150Dysdiadochokinesis (HP:0002075)2.00236763
151Combined immunodeficiency (HP:0005387)2.00176542
152Shallow orbits (HP:0000586)1.99628091
153Glossoptosis (HP:0000162)1.97567555
154Hypopigmentation of the fundus (HP:0007894)1.97460883
155Neoplasm of the heart (HP:0100544)1.97455571
156Abnormality of the labia (HP:0000058)1.96936964
157Abnormality of the pubic bones (HP:0003172)1.96820288
158Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.96100221
159Embryonal neoplasm (HP:0002898)1.95996265
160Abnormality of the intrinsic pathway (HP:0010989)1.94688427
161Progressive external ophthalmoplegia (HP:0000590)1.94674291
162Posterior subcapsular cataract (HP:0007787)1.94307883
163Type I transferrin isoform profile (HP:0003642)1.94154731
164Spinal cord compression (HP:0002176)1.94006854
165Cheilitis (HP:0100825)1.93951410
166Supernumerary nipples (HP:0002558)1.92816972
167Skin pits (HP:0100276)1.92789999
168Vertebral fusion (HP:0002948)1.92360397
169Aplasia involving forearm bones (HP:0009822)1.90885563
170Absent forearm bone (HP:0003953)1.90885563
171Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86153248
172Optic nerve hypoplasia (HP:0000609)1.85135390
173Generalized aminoaciduria (HP:0002909)1.84714943
174Limb hypertonia (HP:0002509)1.84545111
175Abnormality of midbrain morphology (HP:0002418)1.81003431
176Molar tooth sign on MRI (HP:0002419)1.81003431
177Hypergonadotropic hypogonadism (HP:0000815)1.80979995
178Anhidrosis (HP:0000970)1.80596525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.65201204
2MAP3K135.66251493
3ARAF5.48294002
4GRK55.32899493
5ERN14.54721874
6GRK64.22064887
7NEK63.19028287
8CDK93.10999444
9BRAF3.10309528
10GRK13.08176256
11ADRBK23.03441758
12CSF1R2.90766300
13TTK2.78352526
14MET2.77891848
15STK242.76144472
16TGFBR22.73418728
17TYRO32.52303406
18GRK72.50580606
19MAPK72.37784446
20TAOK32.33463657
21STK102.30195386
22MATK2.21840909
23MOS2.08684302
24WNK11.96048726
25KSR21.87488486
26NEK91.86216295
27EIF2AK31.82789376
28RAF11.79013789
29NTRK21.78008196
30CDK71.66749500
31ZAK1.51128390
32PRKG21.46041496
33CAMK41.43826521
34EPHA21.39524819
35STK31.36193373
36CHEK21.36126181
37MST41.34306251
38KSR11.34019420
39TNIK1.33522647
40NTRK11.33229573
41AKT31.31888360
42NUAK11.30586158
43PAK41.27352898
44MELK1.26443632
45PLK11.25957434
46MARK21.18632568
47TRIM281.13403501
48HIPK21.11090906
49ACVR1B1.07824353
50MAP2K41.06797947
51BMPR1B1.05202461
52MAP3K101.03299713
53ADRBK11.03259444
54STK391.02134382
55TIE10.95684781
56FGFR30.90658063
57CDK190.89492270
58CDC70.88581512
59PLK30.84639050
60MARK30.84454463
61CHEK10.82675295
62OXSR10.81114786
63CSNK1G10.80533631
64AKT20.77490572
65ALK0.74705726
66EIF2AK20.73785763
67VRK10.73293818
68NEK20.72526367
69BRSK10.71631792
70WEE10.69998741
71CSNK1D0.68272462
72BUB10.68150814
73MAP2K60.67745131
74CSK0.67576538
75BRSK20.65971859
76TGFBR10.64392942
77MAPK120.63693794
78MAP3K70.61222015
79PRKG10.59994114
80CSNK1G30.59218128
81TNK20.58776408
82AURKA0.57816546
83RPS6KB20.54856671
84LATS20.53254821
85CDK20.51609359
86MTOR0.51383757
87AURKB0.50280413
88MAPK130.48659311
89CDK40.45428886
90DYRK30.44663432
91PBK0.44233549
92NEK10.43013531
93PRKCI0.42850442
94DMPK0.42632494
95CAMK2A0.41904556
96PLK40.41213367
97CSNK1A1L0.40092705
98BMPR20.39879799
99ATM0.39604140
100CSNK1G20.38837891
101PRKCZ0.38673647
102STK40.38000110
103PKN10.37881564
104NTRK30.36998524
105MAP3K40.36867694
106IKBKB0.34851570
107PAK10.34425005
108PRKCD0.33834046
109ERBB20.33819417
110MAP3K50.33565669
111FRK0.32600368
112DYRK20.31945678
113EPHA40.31698958
114IGF1R0.31493761
115MAP3K90.31434212
116CDK50.31015329
117PTK20.30828763
118CSNK1E0.30672854
119MAPKAPK30.30027904
120CDK10.29115024
121SRPK10.28746318
122WNK30.28590677
123EGFR0.28564526
124PRKAA10.26238252
125TLK10.25880972
126MAPK100.25429449
127DYRK1A0.23196308
128MAPK10.21428285
129RIPK10.21149206
130GSK3B0.21056615
131LATS10.20852660
132MAPK140.20190469
133BMX0.20073062
134STK38L0.19593373
135TRPM70.19468902
136ITK0.18755923
137CDK150.18598743
138PRKACG0.18249990
139INSR0.18174810
140CDK11A0.17173161
141MAPK40.16833011
142TAOK20.16408178
143MAP3K80.16403397
144ICK0.15848899
145PRKACB0.15692174
146MAP2K10.14832771
147CDK180.14537314
148PDK10.14283265
149LRRK20.13512428
150DYRK1B0.13413831
151PNCK0.13258874
152STK380.12974324
153PDGFRA0.12855409
154CHUK0.12501810
155PRKD20.11807049
156ATR0.11642678
157PIM10.10577478
158RPS6KA30.10349328
159PRKACA0.10334946
160CDK80.10028532
161BRD40.09864961
162GSK3A0.09860726
163AKT10.08798750

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.65660371
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.96965794
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.44729738
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.89595601
5Fructose and mannose metabolism_Homo sapiens_hsa000513.87039374
6Oocyte meiosis_Homo sapiens_hsa041143.70498199
7Caffeine metabolism_Homo sapiens_hsa002323.37636102
8Galactose metabolism_Homo sapiens_hsa000522.70454641
9Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.69059789
10Arachidonic acid metabolism_Homo sapiens_hsa005902.62125590
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.49951183
12Dorso-ventral axis formation_Homo sapiens_hsa043202.44497591
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.41483464
14Circadian rhythm_Homo sapiens_hsa047102.24432466
15RNA transport_Homo sapiens_hsa030132.05119939
16Linoleic acid metabolism_Homo sapiens_hsa005912.02945920
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.91377237
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88668781
19Olfactory transduction_Homo sapiens_hsa047401.88261147
20DNA replication_Homo sapiens_hsa030301.87476688
21Fanconi anemia pathway_Homo sapiens_hsa034601.82529759
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.76367368
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69473938
24Ribosome_Homo sapiens_hsa030101.65652143
25Thyroid cancer_Homo sapiens_hsa052161.55731217
26Mismatch repair_Homo sapiens_hsa034301.54044847
27Cell cycle_Homo sapiens_hsa041101.48498321
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45874984
29mRNA surveillance pathway_Homo sapiens_hsa030151.45464355
30Homologous recombination_Homo sapiens_hsa034401.44669301
31One carbon pool by folate_Homo sapiens_hsa006701.43102428
32Gap junction_Homo sapiens_hsa045401.43030649
33mTOR signaling pathway_Homo sapiens_hsa041501.41084016
34Phototransduction_Homo sapiens_hsa047441.35427721
35Nicotine addiction_Homo sapiens_hsa050331.31208367
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18514530
37RNA degradation_Homo sapiens_hsa030181.14194825
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11867502
39ABC transporters_Homo sapiens_hsa020101.11500077
40Spliceosome_Homo sapiens_hsa030401.10347514
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09152159
42Chemical carcinogenesis_Homo sapiens_hsa052041.09107588
43Other glycan degradation_Homo sapiens_hsa005111.01997943
44Folate biosynthesis_Homo sapiens_hsa007900.99817761
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96967891
46p53 signaling pathway_Homo sapiens_hsa041150.95928711
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95808647
48Pentose phosphate pathway_Homo sapiens_hsa000300.95380088
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.94542791
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90741151
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90656921
52Base excision repair_Homo sapiens_hsa034100.90189872
53RNA polymerase_Homo sapiens_hsa030200.90126807
54Morphine addiction_Homo sapiens_hsa050320.86933161
55GABAergic synapse_Homo sapiens_hsa047270.85245306
56Sulfur relay system_Homo sapiens_hsa041220.83998563
57TGF-beta signaling pathway_Homo sapiens_hsa043500.74660512
58Ovarian steroidogenesis_Homo sapiens_hsa049130.71781968
59Basal transcription factors_Homo sapiens_hsa030220.71319528
60Synaptic vesicle cycle_Homo sapiens_hsa047210.70635421
61Taste transduction_Homo sapiens_hsa047420.69957487
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.69513456
63Ether lipid metabolism_Homo sapiens_hsa005650.69205707
64Inositol phosphate metabolism_Homo sapiens_hsa005620.68527394
65Bile secretion_Homo sapiens_hsa049760.66963653
66Tryptophan metabolism_Homo sapiens_hsa003800.66921445
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.66846240
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66167635
69Vitamin digestion and absorption_Homo sapiens_hsa049770.65141480
70Basal cell carcinoma_Homo sapiens_hsa052170.63116871
71Acute myeloid leukemia_Homo sapiens_hsa052210.61692885
72Carbon metabolism_Homo sapiens_hsa012000.61012086
73Pathways in cancer_Homo sapiens_hsa052000.60742959
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60601271
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60515855
76MicroRNAs in cancer_Homo sapiens_hsa052060.59663062
77Biosynthesis of amino acids_Homo sapiens_hsa012300.59408877
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57370508
79Herpes simplex infection_Homo sapiens_hsa051680.56480925
80Long-term depression_Homo sapiens_hsa047300.54601166
81FoxO signaling pathway_Homo sapiens_hsa040680.54449955
82Nucleotide excision repair_Homo sapiens_hsa034200.54146984
83Propanoate metabolism_Homo sapiens_hsa006400.53604295
84Purine metabolism_Homo sapiens_hsa002300.53180657
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.52159432
86Hedgehog signaling pathway_Homo sapiens_hsa043400.52136699
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50958594
88Pyrimidine metabolism_Homo sapiens_hsa002400.50889874
89Non-homologous end-joining_Homo sapiens_hsa034500.50069663
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49568006
91Serotonergic synapse_Homo sapiens_hsa047260.49519555
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48578650
93Bladder cancer_Homo sapiens_hsa052190.47398509
94Choline metabolism in cancer_Homo sapiens_hsa052310.47246933
95Fatty acid elongation_Homo sapiens_hsa000620.46543417
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44435938
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43162275
98Non-small cell lung cancer_Homo sapiens_hsa052230.42548300
99Selenocompound metabolism_Homo sapiens_hsa004500.41710307
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39668791
101Complement and coagulation cascades_Homo sapiens_hsa046100.37989319
102Regulation of autophagy_Homo sapiens_hsa041400.37913920
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37722020
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37021983
105Systemic lupus erythematosus_Homo sapiens_hsa053220.36597227
106Adherens junction_Homo sapiens_hsa045200.36248439
107Hippo signaling pathway_Homo sapiens_hsa043900.36244915
108AMPK signaling pathway_Homo sapiens_hsa041520.35896398
109Rap1 signaling pathway_Homo sapiens_hsa040150.35764210
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34294132
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.34262087
112African trypanosomiasis_Homo sapiens_hsa051430.33335515
113Apoptosis_Homo sapiens_hsa042100.31575884
114Viral carcinogenesis_Homo sapiens_hsa052030.31332794
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29538864
116Metabolic pathways_Homo sapiens_hsa011000.28646819
117Notch signaling pathway_Homo sapiens_hsa043300.28350937
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27760258
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27507171
120Ras signaling pathway_Homo sapiens_hsa040140.21391122
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21377694
122Wnt signaling pathway_Homo sapiens_hsa043100.20456255
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20406740
124Huntingtons disease_Homo sapiens_hsa050160.20256801
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19764774
126cAMP signaling pathway_Homo sapiens_hsa040240.19205471
127ErbB signaling pathway_Homo sapiens_hsa040120.18697476
128Oxytocin signaling pathway_Homo sapiens_hsa049210.17779960
129HTLV-I infection_Homo sapiens_hsa051660.17250120
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16422888
131Calcium signaling pathway_Homo sapiens_hsa040200.16215508
132Phagosome_Homo sapiens_hsa041450.16199320
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15418428
134Maturity onset diabetes of the young_Homo sapiens_hsa049500.15380168
135Proteoglycans in cancer_Homo sapiens_hsa052050.14714767
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14237246
137Circadian entrainment_Homo sapiens_hsa047130.13826345
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.13676236
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13021546
140Small cell lung cancer_Homo sapiens_hsa052220.12391806
141Glutamatergic synapse_Homo sapiens_hsa047240.11756353
142Retinol metabolism_Homo sapiens_hsa008300.11636095
143Cyanoamino acid metabolism_Homo sapiens_hsa004600.11085741
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.10651369
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.09992793
146Lysine degradation_Homo sapiens_hsa003100.09454485
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.08691761
148Cholinergic synapse_Homo sapiens_hsa047250.06637792
149Endometrial cancer_Homo sapiens_hsa052130.06560699
150Dopaminergic synapse_Homo sapiens_hsa047280.06190886
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.04922878
152Protein digestion and absorption_Homo sapiens_hsa049740.04068648
153Arginine and proline metabolism_Homo sapiens_hsa003300.00844306
154Renal cell carcinoma_Homo sapiens_hsa052110.00471366

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