RECK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1type B pancreatic cell proliferation (GO:0044342)6.00593170
2collagen fibril organization (GO:0030199)5.02575077
3skin morphogenesis (GO:0043589)4.74446398
4protein heterotrimerization (GO:0070208)4.74361649
5bone trabecula formation (GO:0060346)4.67209817
6adhesion of symbiont to host cell (GO:0044650)4.63878223
7virion attachment to host cell (GO:0019062)4.63878223
8neuron projection extension involved in neuron projection guidance (GO:1902284)4.35723358
9axon extension involved in axon guidance (GO:0048846)4.35723358
10chondrocyte development (GO:0002063)4.32592514
11sequestering of extracellular ligand from receptor (GO:0035581)4.17601476
12regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.16779599
13negative regulation of smooth muscle cell migration (GO:0014912)4.16727593
14cell migration involved in heart development (GO:0060973)4.04815225
15glomerular basement membrane development (GO:0032836)3.98933448
16glomerular filtration (GO:0003094)3.95702606
17cellular response to vitamin (GO:0071295)3.95569403
18cell proliferation involved in metanephros development (GO:0072203)3.90137354
19peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.87495498
20positive regulation of endothelial cell apoptotic process (GO:2000353)3.81966356
21adhesion of symbiont to host (GO:0044406)3.80959432
22pericardium development (GO:0060039)3.79634421
23negative regulation of chondrocyte differentiation (GO:0032331)3.79120955
24chondrocyte proliferation (GO:0035988)3.79118911
25regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.75338618
26craniofacial suture morphogenesis (GO:0097094)3.75300731
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.72702214
28dermatan sulfate biosynthetic process (GO:0030208)3.72568805
29keratan sulfate catabolic process (GO:0042340)3.65682851
30cell proliferation involved in kidney development (GO:0072111)3.64924750
31regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.63956078
32positive regulation of fibroblast migration (GO:0010763)3.63339425
33cell adhesion mediated by integrin (GO:0033627)3.61055434
34heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.59116872
35renal filtration (GO:0097205)3.58993942
36tooth mineralization (GO:0034505)3.55659080
37venous blood vessel morphogenesis (GO:0048845)3.53370521
38regulation of establishment of planar polarity (GO:0090175)3.48758963
39lateral sprouting from an epithelium (GO:0060601)3.48234721
40endocardial cushion morphogenesis (GO:0003203)3.46528794
41collagen metabolic process (GO:0032963)3.43749245
42dermatan sulfate metabolic process (GO:0030205)3.43280336
43endocardial cushion development (GO:0003197)3.42867669
44negative regulation of cartilage development (GO:0061037)3.41604046
45extracellular fibril organization (GO:0043206)3.40481752
46retina vasculature morphogenesis in camera-type eye (GO:0061299)3.36730796
47collagen catabolic process (GO:0030574)3.36718286
48negative regulation of catenin import into nucleus (GO:0035414)3.35046908
49regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.33799253
50negative regulation of BMP signaling pathway (GO:0030514)3.32125883
51polarized epithelial cell differentiation (GO:0030859)3.31844674
52cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.31682321
53regulation of plasminogen activation (GO:0010755)3.31097398
54outer ear morphogenesis (GO:0042473)3.29525317
55middle ear morphogenesis (GO:0042474)3.29400968
56multicellular organismal macromolecule metabolic process (GO:0044259)3.26615090
57regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.25501822
58regulation of chemokine-mediated signaling pathway (GO:0070099)3.25319648
59substrate-dependent cell migration (GO:0006929)3.24726754
60negative regulation of leukocyte chemotaxis (GO:0002689)3.23641284
61G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.23508770
62basement membrane organization (GO:0071711)3.23456072
63mesenchymal cell proliferation (GO:0010463)3.23166425
64hippo signaling (GO:0035329)3.22143121
65mesenchyme morphogenesis (GO:0072132)3.21847226
66Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.19621388
67lung lobe morphogenesis (GO:0060463)3.16740166
68hyaluronan catabolic process (GO:0030214)3.14918023
69endodermal cell differentiation (GO:0035987)3.13810762
70substrate adhesion-dependent cell spreading (GO:0034446)3.13721012
71mesenchymal-epithelial cell signaling (GO:0060638)3.12642160
72glial cell migration (GO:0008347)3.11707924
73insulin-like growth factor receptor signaling pathway (GO:0048009)3.11249573
74regulation of integrin-mediated signaling pathway (GO:2001044)3.10819726
75cranial suture morphogenesis (GO:0060363)3.10760490
76multicellular organismal catabolic process (GO:0044243)3.10010322
77metanephric mesenchyme development (GO:0072075)3.09691124
78protein localization to cell surface (GO:0034394)3.08161418
79paraxial mesoderm development (GO:0048339)3.08088415
80negative regulation of osteoblast proliferation (GO:0033689)3.06816275
81extracellular matrix assembly (GO:0085029)3.06668369
82cellular response to vitamin D (GO:0071305)3.06554130
83multicellular organismal metabolic process (GO:0044236)3.05659800
84peripheral nervous system axon ensheathment (GO:0032292)3.03804356
85myelination in peripheral nervous system (GO:0022011)3.03804356
86wound healing, spreading of epidermal cells (GO:0035313)3.03150675
87positive regulation of mesenchymal cell proliferation (GO:0002053)3.03145324
88cellular response to amino acid stimulus (GO:0071230)3.02955917
89apoptotic cell clearance (GO:0043277)3.02064595
90positive regulation of blood vessel endothelial cell migration (GO:0043536)3.01516541
91regulation of non-canonical Wnt signaling pathway (GO:2000050)3.00723117
92regulation of extracellular matrix disassembly (GO:0010715)3.00426775
93* blood vessel maturation (GO:0001955)2.98724019
94camera-type eye morphogenesis (GO:0048593)2.97873548
95negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.97024958
96regulation of mesenchymal cell proliferation (GO:0010464)2.96078404
97kidney mesenchyme development (GO:0072074)2.95884137
98smooth muscle tissue development (GO:0048745)2.94151447
99positive regulation of osteoblast proliferation (GO:0033690)2.93589859
100regulation of axon extension involved in axon guidance (GO:0048841)2.93537692
101endothelial cell morphogenesis (GO:0001886)2.93385844
102embryonic cranial skeleton morphogenesis (GO:0048701)2.92460845
103regulation of catenin import into nucleus (GO:0035412)2.91466142
104negative regulation of axon extension involved in axon guidance (GO:0048843)2.90783889
105negative regulation of fatty acid transport (GO:2000192)2.90271205
106non-canonical Wnt signaling pathway (GO:0035567)2.89871690
107protein retention in ER lumen (GO:0006621)2.88696557
108notochord development (GO:0030903)2.88153395
109regulation of cartilage development (GO:0061035)2.87008986
110stress fiber assembly (GO:0043149)2.86456118
111heparan sulfate proteoglycan metabolic process (GO:0030201)2.85879227
112coronary vasculature morphogenesis (GO:0060977)2.85238865
113sprouting angiogenesis (GO:0002040)2.85070402
114protein targeting to plasma membrane (GO:0072661)2.84670500
115embryonic skeletal joint morphogenesis (GO:0060272)2.83991828
116regulation of chondrocyte differentiation (GO:0032330)2.82847690
117lymphangiogenesis (GO:0001946)2.81050715
118positive regulation of catenin import into nucleus (GO:0035413)2.80712719
119positive regulation of cartilage development (GO:0061036)2.80692612
120regulation of axon guidance (GO:1902667)2.80558056
121barbed-end actin filament capping (GO:0051016)2.78791789
122vascular endothelial growth factor signaling pathway (GO:0038084)2.78594250
123regulation of osteoblast proliferation (GO:0033688)2.78253909
124lymph vessel development (GO:0001945)2.78135647
125fibril organization (GO:0097435)2.77823546
126face morphogenesis (GO:0060325)2.76342246
127positive regulation of epithelial to mesenchymal transition (GO:0010718)2.76310858
128extracellular matrix disassembly (GO:0022617)2.75929250
129regulation of heart morphogenesis (GO:2000826)2.75241195
130extracellular negative regulation of signal transduction (GO:1900116)2.75017349
131extracellular regulation of signal transduction (GO:1900115)2.75017349
132cochlea morphogenesis (GO:0090103)2.74984424
133negative regulation of embryonic development (GO:0045992)2.74916522
134maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74851497
135mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.73183042
136regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.72642735
137mesodermal cell differentiation (GO:0048333)2.72483533
138artery development (GO:0060840)2.71696524
139negative regulation of axon guidance (GO:1902668)2.71225144
140atrioventricular valve morphogenesis (GO:0003181)2.68750012
141regulation of collagen metabolic process (GO:0010712)2.68421969
142negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.68218167
143regulation of smooth muscle cell migration (GO:0014910)2.68110047
144cell migration involved in sprouting angiogenesis (GO:0002042)2.65115159
145body morphogenesis (GO:0010171)2.64057681
146anatomical structure regression (GO:0060033)2.63835406
147glomerulus development (GO:0032835)2.63204504
148* extracellular matrix organization (GO:0030198)2.60452614
149* extracellular structure organization (GO:0043062)2.59568789

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.89560107
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83444539
3EED_16625203_ChIP-ChIP_MESCs_Mouse2.69839951
4* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.67985297
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.56224566
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45033900
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45033900
8EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.32310286
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30888170
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29922948
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27898076
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.24944691
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21152654
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.17761648
15AR_21572438_ChIP-Seq_LNCaP_Human2.14187425
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12424509
17CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.09104427
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.07719324
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06915390
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.06214492
21EP300_21415370_ChIP-Seq_HL-1_Mouse2.04931958
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04241459
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.02289656
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00913698
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92461635
26CLOCK_20551151_ChIP-Seq_293T_Human1.91678143
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88734197
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.87514332
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87465339
30* CJUN_26792858_Chip-Seq_BT549_Human1.80153878
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.74307201
32EZH2_22144423_ChIP-Seq_EOC_Human1.73670458
33ISL1_27105846_Chip-Seq_CPCs_Mouse1.68663377
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66478562
35SA1_22415368_ChIP-Seq_MEFs_Mouse1.64373308
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64111016
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62256364
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.61517451
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59789204
40* TP53_16413492_ChIP-PET_HCT116_Human1.58543573
41* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57179477
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56846936
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56548390
44* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55408620
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52806664
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51495831
47GBX2_23144817_ChIP-Seq_PC3_Human1.50514535
48BRD4_25478319_ChIP-Seq_HGPS_Human1.50473345
49TP53_18474530_ChIP-ChIP_U2OS_Human1.49664949
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45489682
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.44889879
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.44842115
53WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41286497
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40857167
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.38600923
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38212764
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36903397
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36903397
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34773437
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.34122727
61MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.33898233
62SMC3_22415368_ChIP-Seq_MEFs_Mouse1.33357315
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.32552879
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.31955777
65* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31880158
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.31501630
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30811665
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30802997
69DROSHA_22980978_ChIP-Seq_HELA_Human1.30111059
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.29513064
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.29317018
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.29211536
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29136146
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.28711685
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26183584
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24295640
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24175538
78AHR_22903824_ChIP-Seq_MCF-7_Human1.23873297
79TP53_23651856_ChIP-Seq_MEFs_Mouse1.21929330
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21542012
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21372961
82* TP53_22127205_ChIP-Seq_IMR90_Human1.20156754
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19525210
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18824913
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.14830571
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13505879
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13505879
88* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11367582
89TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10801220
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10701946
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10512375
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10366838
93FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10033772
94SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09079586
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08043477
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06942075
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02382761
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02370652
99PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02090464
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01109445
101RXR_22108803_ChIP-Seq_LS180_Human1.01016798
102UBF1/2_26484160_Chip-Seq_HMECs_Human1.00929195
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00901267
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00698652
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.99706411
106* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99354392
107PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.99280485
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98906538
109YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98118944
110* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.98080256
111ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97809196
112NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97498323
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97116256
114BCAT_22108803_ChIP-Seq_LS180_Human0.96812321
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96414133
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95731244
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95699947
118NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95554036
119KDM2B_26808549_Chip-Seq_K562_Human0.95329112
120TBX20_22328084_ChIP-Seq_HEART_Mouse0.95145915
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.95145915
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94389018
123SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94098229
124SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93275442
125NFI_21473784_ChIP-Seq_ESCs_Mouse0.92349186
126THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91033640
127PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89128811
128KDM2B_26808549_Chip-Seq_REH_Human0.87146548
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86899733
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84421095
131* TP63_23658742_ChIP-Seq_EP156T_Human0.83520730
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83191886
133EZH2_27294783_Chip-Seq_NPCs_Mouse0.81430877
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80209908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.91346288
2MP0005503_abnormal_tendon_morphology5.70260203
3MP0005275_abnormal_skin_tensile3.84414325
4* MP0004272_abnormal_basement_membrane3.35045808
5MP0009384_cardiac_valve_regurgitation2.83085386
6MP0003705_abnormal_hypodermis_morpholog2.74661720
7MP0001958_emphysema2.72092937
8MP0003279_aneurysm2.69745998
9MP0005623_abnormal_meninges_morphology2.57127983
10MP0010030_abnormal_orbit_morphology2.55802806
11MP0003385_abnormal_body_wall2.54908501
12MP0003122_maternal_imprinting2.50281360
13MP0009250_abnormal_appendicular_skeleto2.39994822
14MP0010368_abnormal_lymphatic_system2.33978583
15MP0005508_abnormal_skeleton_morphology2.29844866
16MP0002282_abnormal_trachea_morphology2.14854730
17MP0002108_abnormal_muscle_morphology2.14521243
18MP0000534_abnormal_ureter_morphology2.07171812
19MP0003942_abnormal_urinary_system1.97614487
20MP0000537_abnormal_urethra_morphology1.96578093
21MP0004134_abnormal_chest_morphology1.93093050
22MP0009053_abnormal_anal_canal1.86213460
23MP0001879_abnormal_lymphatic_vessel1.69477192
24MP0001299_abnormal_eye_distance/1.67583060
25MP0002249_abnormal_larynx_morphology1.62873649
26MP0003937_abnormal_limbs/digits/tail_de1.62153112
27MP0000049_abnormal_middle_ear1.62114990
28MP0002938_white_spotting1.61619331
29MP0006054_spinal_hemorrhage1.59958350
30MP0000013_abnormal_adipose_tissue1.56907794
31MP0003123_paternal_imprinting1.55468534
32MP0002932_abnormal_joint_morphology1.52478945
33MP0000163_abnormal_cartilage_morphology1.51353183
34MP0000428_abnormal_craniofacial_morphol1.51296262
35MP0003935_abnormal_craniofacial_develop1.50460091
36MP0003755_abnormal_palate_morphology1.44892523
37MP0000767_abnormal_smooth_muscle1.43448757
38MP0003115_abnormal_respiratory_system1.39822274
39MP0000566_synostosis1.39316702
40MP0002115_abnormal_skeleton_extremities1.38547817
41MP0002295_abnormal_pulmonary_circulatio1.35905565
42MP0000733_abnormal_muscle_development1.35301779
43MP0000751_myopathy1.33656567
44MP0000762_abnormal_tongue_morphology1.30441327
45MP0002116_abnormal_craniofacial_bone1.29346004
46MP0005171_absent_coat_pigmentation1.28953038
47MP0005257_abnormal_intraocular_pressure1.28742372
48MP0002896_abnormal_bone_mineralization1.28691792
49MP0002109_abnormal_limb_morphology1.23554114
50MP0003566_abnormal_cell_adhesion1.23359349
51MP0003121_genomic_imprinting1.21971622
52MP0000432_abnormal_head_morphology1.21640651
53MP0005248_abnormal_Harderian_gland1.19729426
54MP0010386_abnormal_urinary_bladder1.18853681
55MP0003091_abnormal_cell_migration1.17416258
56MP0000516_abnormal_urinary_system1.16450191
57MP0005367_renal/urinary_system_phenotyp1.16450191
58MP0002113_abnormal_skeleton_development1.13632892
59MP0002837_dystrophic_cardiac_calcinosis1.09587612
60MP0000462_abnormal_digestive_system1.09060595
61MP0004858_abnormal_nervous_system1.06587806
62MP0005390_skeleton_phenotype1.05137663
63MP0001348_abnormal_lacrimal_gland1.05079806
64MP0002233_abnormal_nose_morphology1.03563772
65MP0001270_distended_abdomen1.03356910
66MP0003941_abnormal_skin_development1.01829196
67MP0006138_congestive_heart_failure1.01141940
68MP0003828_pulmonary_edema1.00360261
69* MP0002925_abnormal_cardiovascular_devel1.00180980
70MP0005076_abnormal_cell_differentiation0.98618163
71MP0005023_abnormal_wound_healing0.98497929
72MP0002060_abnormal_skin_morphology0.97474102
73MP0010352_gastrointestinal_tract_polyps0.96298445
74MP0002114_abnormal_axial_skeleton0.94909187
75MP0003119_abnormal_digestive_system0.94688034
76MP0003283_abnormal_digestive_organ0.94651950
77MP0005164_abnormal_response_to0.93726974
78MP0005388_respiratory_system_phenotype0.91299239
79MP0002133_abnormal_respiratory_system0.91299239
80* MP0002128_abnormal_blood_circulation0.89854939
81MP0003045_fibrosis0.88867197
82* MP0001614_abnormal_blood_vessel0.87872817
83MP0002877_abnormal_melanocyte_morpholog0.87439077
84MP0002111_abnormal_tail_morphology0.86190462
85MP0002933_joint_inflammation0.86063359
86MP0003567_abnormal_fetal_cardiomyocyte0.85854214
87MP0004084_abnormal_cardiac_muscle0.85847862
88MP0009780_abnormal_chondrocyte_physiolo0.84965569
89MP0000759_abnormal_skeletal_muscle0.84666271
90MP0002089_abnormal_postnatal_growth/wei0.83770084
91MP0005187_abnormal_penis_morphology0.82917540
92MP0001340_abnormal_eyelid_morphology0.81910403
93MP0001293_anophthalmia0.81636436
94MP0002254_reproductive_system_inflammat0.80780789
95MP0003950_abnormal_plasma_membrane0.80351923
96MP0002168_other_aberrant_phenotype0.78949730
97MP0001175_abnormal_lung_morphology0.78597795
98MP0001177_atelectasis0.78096004
99MP0005197_abnormal_uvea_morphology0.75636052
100MP0003448_altered_tumor_morphology0.73390515
101MP0001243_abnormal_dermal_layer0.73011651
102MP0000266_abnormal_heart_morphology0.73001846
103MP0005595_abnormal_vascular_smooth0.72842580
104MP0000749_muscle_degeneration0.69989059
105MP0001533_abnormal_skeleton_physiology0.69554198
106MP0004883_abnormal_blood_vessel0.69333469
107MP0001286_abnormal_eye_development0.68769288
108MP0002998_abnormal_bone_remodeling0.68382834
109MP0003300_gastrointestinal_ulcer0.68297909
110MP0003795_abnormal_bone_structure0.67430556
111MP0002092_abnormal_eye_morphology0.67339335
112MP0001915_intracranial_hemorrhage0.66442485
113MP0005369_muscle_phenotype0.66198801
114MP0000538_abnormal_urinary_bladder0.65915659
115* MP0004197_abnormal_fetal_growth/weight/0.65421688
116MP0002177_abnormal_outer_ear0.64070912
117MP0000003_abnormal_adipose_tissue0.63318140
118MP0004145_abnormal_muscle_electrophysio0.62878664
119MP0001542_abnormal_bone_strength0.62396556
120MP0010630_abnormal_cardiac_muscle0.61721974
121MP0001849_ear_inflammation0.59789796
122MP0000750_abnormal_muscle_regeneration0.52281014
123MP0005193_abnormal_anterior_eye0.51410870
124MP0004233_abnormal_muscle_weight0.49917836
125MP0001661_extended_life_span0.47094812
126MP0002127_abnormal_cardiovascular_syste0.44866194
127MP0000681_abnormal_thyroid_gland0.44259540

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.85766887
2Premature rupture of membranes (HP:0001788)5.26448697
3Shallow orbits (HP:0000586)4.49928492
4Broad metatarsal (HP:0001783)4.41443923
5Ankle contracture (HP:0006466)3.98047731
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.81943849
7Short 4th metacarpal (HP:0010044)3.81943849
8Aortic dissection (HP:0002647)3.71605347
9Aortic aneurysm (HP:0004942)3.51745033
10Soft skin (HP:0000977)3.38288825
11Cervical subluxation (HP:0003308)3.24287034
12Bladder diverticulum (HP:0000015)3.22018991
13Aortic regurgitation (HP:0001659)3.12342734
14Abnormality of the 4th metacarpal (HP:0010012)3.09516968
15Overgrowth (HP:0001548)2.90525270
16Abnormality of dentin (HP:0010299)2.89138963
17Vascular tortuosity (HP:0004948)2.88615830
18Neonatal short-limb short stature (HP:0008921)2.85804646
19Aortic valve stenosis (HP:0001650)2.82175769
20Cerebral aneurysm (HP:0004944)2.81536223
21Dilatation of the ascending aorta (HP:0005111)2.77910764
22Mitral valve prolapse (HP:0001634)2.73741918
23Epiphyseal dysplasia (HP:0002656)2.73544015
24Atrophic scars (HP:0001075)2.73348794
25Vitreoretinal degeneration (HP:0000655)2.70391323
26Wormian bones (HP:0002645)2.64487639
27Pulmonary artery stenosis (HP:0004415)2.60553911
28Blue sclerae (HP:0000592)2.59791861
29Follicular hyperkeratosis (HP:0007502)2.58456428
30Abnormal delivery (HP:0001787)2.55213775
31Coronal craniosynostosis (HP:0004440)2.54501022
32Wide anterior fontanel (HP:0000260)2.53869192
33Hypoplastic ischia (HP:0003175)2.53567330
34Joint stiffness (HP:0001387)2.52541208
35Mildly elevated creatine phosphokinase (HP:0008180)2.51917864
36Joint laxity (HP:0001388)2.49033262
37Arterial tortuosity (HP:0005116)2.47917509
38Hypoventilation (HP:0002791)2.47162554
39Spinal rigidity (HP:0003306)2.45997113
40Type 1 muscle fiber predominance (HP:0003803)2.43695045
41Redundant skin (HP:0001582)2.43394450
42Midline defect of the nose (HP:0004122)2.42484521
43Abnormality of skeletal muscle fiber size (HP:0012084)2.41193780
44Abnormality of the parietal bone (HP:0002696)2.38058344
45Mesomelia (HP:0003027)2.35609276
46Round ear (HP:0100830)2.34547617
47Broad long bones (HP:0005622)2.32352963
48Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.30677041
49Broad toe (HP:0001837)2.29779767
50Wrist flexion contracture (HP:0001239)2.29679208
51Ovoid vertebral bodies (HP:0003300)2.28992501
52Camptodactyly of toe (HP:0001836)2.28112826
53Short hallux (HP:0010109)2.28021202
54Delayed closure of the anterior fontanelle (HP:0001476)2.27411368
55Hyperextensible skin (HP:0000974)2.26637122
56Fragile skin (HP:0001030)2.24468006
57Nonimmune hydrops fetalis (HP:0001790)2.23925347
58Biconcave vertebral bodies (HP:0004586)2.23531496
59Bell-shaped thorax (HP:0001591)2.20814534
60Disproportionate tall stature (HP:0001519)2.20390746
61Genu recurvatum (HP:0002816)2.20238151
62Buphthalmos (HP:0000557)2.19407789
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.18545229
64Osteolytic defects of the hand bones (HP:0009699)2.18545229
65Abnormality of the ischium (HP:0003174)2.17848948
66Breech presentation (HP:0001623)2.17551712
67Limited hip movement (HP:0008800)2.17415621
68Peritonitis (HP:0002586)2.16171795
69Deviation of the hallux (HP:0010051)2.14845571
70Broad phalanx (HP:0006009)2.14655086
71Slender build (HP:0001533)2.14651267
72Trigonocephaly (HP:0000243)2.11316214
73Abnormality of the phalanges of the 2nd finger (HP:0009541)2.11039285
74Osteoarthritis (HP:0002758)2.09452758
75Broad ribs (HP:0000885)2.09407571
76Long toe (HP:0010511)2.08639641
77Mitral stenosis (HP:0001718)2.08295955
78Delayed cranial suture closure (HP:0000270)2.07569895
79Renal duplication (HP:0000075)2.07558868
80Hip contracture (HP:0003273)2.06161327
81Broad thumb (HP:0011304)2.04582942
82Hepatoblastoma (HP:0002884)2.04539923
83Increased variability in muscle fiber diameter (HP:0003557)2.02776488
84Aplasia/Hypoplasia of the hallux (HP:0008362)2.01780771
85Hallux valgus (HP:0001822)2.01534858
86Abnormality of skull ossification (HP:0002703)2.01275401
87Mild short stature (HP:0003502)2.00138471
88Absent frontal sinuses (HP:0002688)1.99075503
89Broad finger (HP:0001500)1.98857203
90Broad hallux (HP:0010055)1.98064798
91Striae distensae (HP:0001065)1.96719039
92Broad phalanges of the hand (HP:0009768)1.94998359
93Bowel diverticulosis (HP:0005222)1.93048665
94Asymmetry of the thorax (HP:0001555)1.90884528
95Flat cornea (HP:0007720)1.90790182
96Dislocated radial head (HP:0003083)1.90387321
97Ectopia lentis (HP:0001083)1.89890976
98Generalized amyotrophy (HP:0003700)1.87942695
99Increased connective tissue (HP:0009025)1.87463133
100Aneurysm (HP:0002617)1.86595354
101Abnormality of the 2nd finger (HP:0004100)1.85826553
102Microglossia (HP:0000171)1.85565071
103Infantile muscular hypotonia (HP:0008947)1.85351980
104Flared iliac wings (HP:0002869)1.83397371
105Abnormality of the acetabulum (HP:0003170)1.82900578
106Thoracolumbar scoliosis (HP:0002944)1.82280926
107Spondylolisthesis (HP:0003302)1.82234918
108Abnormality of the radial head (HP:0003995)1.82196046
109Flexion contracture of toe (HP:0005830)1.82071956
110Joint contractures involving the joints of the feet (HP:0100492)1.82071956
111Hypoplasia of the iris (HP:0007676)1.80290815
112Protruding ear (HP:0000411)1.80050684
113Keratoconus (HP:0000563)1.79467761
114Increased corneal curvature (HP:0100692)1.79467761
115Mitral regurgitation (HP:0001653)1.79466643
116Narrow nasal bridge (HP:0000446)1.79428768
117Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.79405766
118Tarsal synostosis (HP:0008368)1.79007611
119Limb-girdle muscle weakness (HP:0003325)1.78027803
120Spinal cord lesions (HP:0100561)1.77812414
121Syringomyelia (HP:0003396)1.77812414
122Inguinal hernia (HP:0000023)1.77532336
123Abnormal ossification of hand bones (HP:0005921)1.77350241
124Abnormality of the distal phalanx of the thumb (HP:0009617)1.77262611
125Decreased skull ossification (HP:0004331)1.77096593
126Vertebral compression fractures (HP:0002953)1.76301946
127Natal tooth (HP:0000695)1.76084118
128Premature skin wrinkling (HP:0100678)1.75566328
129Turricephaly (HP:0000262)1.75221994
130Hypoplasia of the odontoid process (HP:0003311)1.75159707
131Ulnar deviation of the wrist (HP:0003049)1.73366028
132Exostoses (HP:0100777)1.73253115
133Gingival overgrowth (HP:0000212)1.72874300
134Emphysema (HP:0002097)1.71522995
135Elbow flexion contracture (HP:0002987)1.71333639
136Venous insufficiency (HP:0005293)1.70943760
137Abnormality of the humeroradial joint (HP:0100744)1.70668888
138Bronchomalacia (HP:0002780)1.70640034
139Ulnar bowing (HP:0003031)1.70161418
140Abnormality of the middle phalanges of the toes (HP:0010183)1.69948420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.82565679
2LATS13.51187869
3EPHB23.40682517
4EPHA33.40284846
5PDGFRA3.29866394
6DMPK3.00949518
7SIK12.76279191
8KIT2.54912513
9FGFR22.25501557
10TTN2.15512482
11PIK3CG2.14345610
12LIMK12.06591671
13TRIB31.92640632
14LATS21.90996144
15TESK11.88077790
16TIE11.87801503
17TGFBR21.86094342
18FLT31.81529929
19PRKD31.71481891
20GRK11.68358138
21NUAK11.65808544
22PTK21.64122212
23MET1.63483063
24NTRK11.63366833
25PTK2B1.59032818
26GRK51.57523690
27EPHB11.52444523
28CAMK1G1.51646269
29GRK71.51492045
30PAK21.50363956
31CCNB11.48911504
32PDGFRB1.42679436
33ICK1.39600667
34FGFR11.38721837
35PTK61.36840791
36PAK41.33529267
37CDK121.33381295
38ABL21.25666584
39ERBB21.25012814
40TGFBR11.24185337
41STK31.22933978
42CDK81.21465900
43ADRBK21.21231888
44WNK11.20770283
45BCR1.20040926
46ERBB31.18878325
47STK38L1.16686811
48ROCK11.16214694
49PKN21.14424934
50KSR11.13513987
51SIK31.09227225
52MOS1.08922243
53MAP3K61.08760469
54FER1.07436285
55TYRO31.07088267
56MTOR1.04829033
57MAP3K31.04194920
58ERBB41.03146213
59RIPK11.02706740
60MYLK1.00895777
61BMX0.98148885
62CAMK1D0.97419224
63JAK10.93734426
64PLK20.90229200
65ROCK20.88959190
66PAK30.86662614
67RPS6KA20.85791862
68ERN10.82680698
69RET0.82666721
70PRKG20.79682891
71KDR0.79099459
72STK390.78816116
73MAP2K30.74736028
74PRKCH0.74047183
75PAK60.73817139
76GRK60.71366820
77MAPK70.68446910
78LRRK20.68186853
79DAPK30.65934110
80TRPM70.64407120
81AKT30.61404228
82PRKD10.60504363
83CLK10.58712100
84MARK20.57783485
85INSR0.57113933
86PIK3CA0.55766235
87CSNK1A1L0.55611913
88PIM20.55009102
89JAK30.54833676
90MAP3K100.54349956
91BMPR1B0.54160989
92TYK20.54112544
93CDK90.52703314
94WNK40.50128991
95NTRK20.48841096
96PRKD20.47409356
97GSK3A0.47339707
98SRC0.46284579
99MAPKAPK30.45593507
100UHMK10.45107995
101CDC42BPA0.45017874
102ILK0.44171205
103NEK90.43456029
104DYRK1B0.43400549
105RPS6KL10.42734097
106RPS6KC10.42734097
107MAPK10.42529044
108MAP3K70.39183330
109IGF1R0.38573778
110FGFR40.37552057
111ADRBK10.36730225
112PNCK0.34990291
113CAMK2G0.34456969
114ABL10.33707716
115PRKCE0.32669909
116CHEK20.32210071
117MAP2K10.31420002
118MKNK10.31119138
119PLK30.30428028
120CSNK1G10.29911524
121MELK0.29845217
122STK380.29831932
123SGK30.29804585
124FGFR30.29065995
125RPS6KA60.28844871
126MAPK90.28729177
127INSRR0.27453663
128TBK10.27395327
129PAK10.27308535
130CAMK10.26854714
131SGK20.26808668
132IRAK10.26066680
133CAMK40.25867061
134MAP2K20.25722314
135MAPK80.24693869
136CDK60.24187316
137BRD40.24125261
138ZAP700.23547286
139DYRK1A0.23267408
140MAPKAPK20.22202009
141BCKDK0.21193150
142MAPK40.20990055
143STK40.20753340
144NLK0.18671641

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.99313956
2Basal cell carcinoma_Homo sapiens_hsa052172.87244253
3Focal adhesion_Homo sapiens_hsa045102.79968939
4Protein digestion and absorption_Homo sapiens_hsa049742.57584477
5Hedgehog signaling pathway_Homo sapiens_hsa043402.50265164
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.39351595
7Adherens junction_Homo sapiens_hsa045202.34552792
8Hippo signaling pathway_Homo sapiens_hsa043902.29290019
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.18090552
10TGF-beta signaling pathway_Homo sapiens_hsa043502.17354724
11Axon guidance_Homo sapiens_hsa043602.11436031
12Proteoglycans in cancer_Homo sapiens_hsa052052.11324990
13Dilated cardiomyopathy_Homo sapiens_hsa054141.95419631
14Wnt signaling pathway_Homo sapiens_hsa043101.91807614
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.83470173
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.70870493
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.64254564
18Amoebiasis_Homo sapiens_hsa051461.58212593
19Small cell lung cancer_Homo sapiens_hsa052221.52489065
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.50088669
21* MicroRNAs in cancer_Homo sapiens_hsa052061.50067809
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48949719
23Viral myocarditis_Homo sapiens_hsa054161.47670508
24Melanogenesis_Homo sapiens_hsa049161.44837040
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.37873061
26Prostate cancer_Homo sapiens_hsa052151.34183810
27Pathways in cancer_Homo sapiens_hsa052001.29558556
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.25116293
29Rap1 signaling pathway_Homo sapiens_hsa040151.24678793
30Other glycan degradation_Homo sapiens_hsa005111.23049116
31Complement and coagulation cascades_Homo sapiens_hsa046101.17432420
32Tight junction_Homo sapiens_hsa045301.15153735
33Colorectal cancer_Homo sapiens_hsa052101.13854155
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12651256
35Renal cell carcinoma_Homo sapiens_hsa052111.11582198
36Melanoma_Homo sapiens_hsa052181.11178478
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09749734
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.07721323
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07666529
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06026008
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05340320
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.05215205
43Glioma_Homo sapiens_hsa052141.04093085
44Lysosome_Homo sapiens_hsa041421.02670277
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01051946
46Chronic myeloid leukemia_Homo sapiens_hsa052201.00414112
47Bladder cancer_Homo sapiens_hsa052191.00205477
48Lysine degradation_Homo sapiens_hsa003100.98618489
49Gap junction_Homo sapiens_hsa045400.96000272
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95219761
51Platelet activation_Homo sapiens_hsa046110.94854088
52Estrogen signaling pathway_Homo sapiens_hsa049150.93869034
53Thyroid hormone synthesis_Homo sapiens_hsa049180.92255211
54Renin secretion_Homo sapiens_hsa049240.89678142
55Pancreatic cancer_Homo sapiens_hsa052120.88365211
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87015623
57Notch signaling pathway_Homo sapiens_hsa043300.86601318
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86449518
59cAMP signaling pathway_Homo sapiens_hsa040240.85944136
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85662361
61Dorso-ventral axis formation_Homo sapiens_hsa043200.83465923
62Malaria_Homo sapiens_hsa051440.82070807
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81367674
64Oxytocin signaling pathway_Homo sapiens_hsa049210.80037530
65Pertussis_Homo sapiens_hsa051330.79803020
66HTLV-I infection_Homo sapiens_hsa051660.78931209
67Sulfur metabolism_Homo sapiens_hsa009200.78827529
68Ras signaling pathway_Homo sapiens_hsa040140.78815018
69Endometrial cancer_Homo sapiens_hsa052130.78544319
70Phagosome_Homo sapiens_hsa041450.76968364
71p53 signaling pathway_Homo sapiens_hsa041150.75627695
72MAPK signaling pathway_Homo sapiens_hsa040100.73030767
73Cocaine addiction_Homo sapiens_hsa050300.70608558
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67672094
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.64930569
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.64056173
77Circadian entrainment_Homo sapiens_hsa047130.64025951
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63792564
79Ovarian steroidogenesis_Homo sapiens_hsa049130.62923794
80ErbB signaling pathway_Homo sapiens_hsa040120.62575306
81Amphetamine addiction_Homo sapiens_hsa050310.61737601
82Insulin resistance_Homo sapiens_hsa049310.60902143
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.60381310
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59880960
85Toxoplasmosis_Homo sapiens_hsa051450.58079544
86Choline metabolism in cancer_Homo sapiens_hsa052310.57771735
87Calcium signaling pathway_Homo sapiens_hsa040200.57636789
88Renin-angiotensin system_Homo sapiens_hsa046140.56597248
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56519849
90GnRH signaling pathway_Homo sapiens_hsa049120.56483116
91TNF signaling pathway_Homo sapiens_hsa046680.55293390
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54569834
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54446755
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54157071
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.52745023
96Gastric acid secretion_Homo sapiens_hsa049710.51422336
97Dopaminergic synapse_Homo sapiens_hsa047280.51289263
98Cholinergic synapse_Homo sapiens_hsa047250.51253687
99Endocytosis_Homo sapiens_hsa041440.51145761
100Oocyte meiosis_Homo sapiens_hsa041140.50852925
101Prion diseases_Homo sapiens_hsa050200.50580739
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50477887
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50424923
104Long-term depression_Homo sapiens_hsa047300.49917421
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49553193
106Vibrio cholerae infection_Homo sapiens_hsa051100.49512895
107Salivary secretion_Homo sapiens_hsa049700.49042297
108Shigellosis_Homo sapiens_hsa051310.48659084
109Selenocompound metabolism_Homo sapiens_hsa004500.47760612
110VEGF signaling pathway_Homo sapiens_hsa043700.46773733
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.45968126
112Hepatitis B_Homo sapiens_hsa051610.44808110
113mTOR signaling pathway_Homo sapiens_hsa041500.43379020
114FoxO signaling pathway_Homo sapiens_hsa040680.43126514
115Thyroid cancer_Homo sapiens_hsa052160.42898898
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42501957
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41877190
118Long-term potentiation_Homo sapiens_hsa047200.41745675
119N-Glycan biosynthesis_Homo sapiens_hsa005100.41736621
120AMPK signaling pathway_Homo sapiens_hsa041520.40338034
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40125596
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33801963
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.31235915
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27414159
125Prolactin signaling pathway_Homo sapiens_hsa049170.26999754

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