RECQL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. The encoded protein is involved in the processing of Holliday junctions, the suppression of sister chromatid exchanges, telomere maintenance, and is required for genotoxic stress resistance. Defects in this gene have been associated with several types of cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)9.42462371
2antigen processing and presentation of endogenous antigen (GO:0019883)7.94539807
3positive regulation of antigen processing and presentation (GO:0002579)7.19740907
4proteasome assembly (GO:0043248)6.92696812
5nuclear envelope reassembly (GO:0031468)6.38672368
6mitotic nuclear envelope reassembly (GO:0007084)6.38672368
7peptidyl-lysine dimethylation (GO:0018027)6.09455644
8negative regulation of catenin import into nucleus (GO:0035414)5.94495004
9positive regulation of B cell differentiation (GO:0045579)5.93287072
10negative regulation of bone resorption (GO:0045779)5.74678997
11T cell migration (GO:0072678)5.65083603
12regulation of antigen processing and presentation (GO:0002577)5.37928929
13negative regulation of bone remodeling (GO:0046851)5.21455225
14leukocyte tethering or rolling (GO:0050901)4.85876013
15positive regulation of protein export from nucleus (GO:0046827)4.84850436
16determination of adult lifespan (GO:0008340)4.69874685
17immunoglobulin mediated immune response (GO:0016064)4.48391970
18B cell mediated immunity (GO:0019724)4.42787636
19negative regulation of B cell proliferation (GO:0030889)4.36961529
20negative regulation of osteoclast differentiation (GO:0045671)4.26247496
21meiotic chromosome segregation (GO:0045132)4.21579997
22negative regulation of tissue remodeling (GO:0034104)4.20928537
23telomere maintenance via semi-conservative replication (GO:0032201)4.09312625
24regulation of DNA endoreduplication (GO:0032875)4.08455749
25kinetochore organization (GO:0051383)4.05213785
26platelet dense granule organization (GO:0060155)4.02498220
27regulation of B cell differentiation (GO:0045577)4.01577389
28microtubule depolymerization (GO:0007019)3.97706483
29DNA strand elongation involved in DNA replication (GO:0006271)3.88689472
30negative regulation of DNA-dependent DNA replication (GO:2000104)3.88627161
31telomere maintenance via recombination (GO:0000722)3.83868057
32adaptation of signaling pathway (GO:0023058)3.80750963
33regulation of monocyte differentiation (GO:0045655)3.80029923
34DNA strand elongation (GO:0022616)3.78710246
35CENP-A containing nucleosome assembly (GO:0034080)3.70385721
36mitotic recombination (GO:0006312)3.65829651
37chromatin remodeling at centromere (GO:0031055)3.57638080
38mismatch repair (GO:0006298)3.57491130
39regulation of protein export from nucleus (GO:0046825)3.57326314
40heterotypic cell-cell adhesion (GO:0034113)3.55060703
41regulation of nuclear cell cycle DNA replication (GO:0033262)3.53833168
42regulation of interferon-beta biosynthetic process (GO:0045357)3.51514623
43neutrophil activation involved in immune response (GO:0002283)3.49463005
44telomere maintenance via telomere lengthening (GO:0010833)3.47502402
45intra-S DNA damage checkpoint (GO:0031573)3.43646353
46kinetochore assembly (GO:0051382)3.37982378
47positive regulation of gamma-delta T cell activation (GO:0046645)3.37921924
48DNA synthesis involved in DNA repair (GO:0000731)3.33639243
49DNA replication initiation (GO:0006270)3.26810024
50regulation of interleukin-6 biosynthetic process (GO:0045408)3.26689758
51activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.25997695
52antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.24145254
53positive regulation of chemokine biosynthetic process (GO:0045080)3.22371410
54DNA replication-independent nucleosome organization (GO:0034724)3.22225867
55DNA replication-independent nucleosome assembly (GO:0006336)3.22225867
56membrane disassembly (GO:0030397)3.19882423
57nuclear envelope disassembly (GO:0051081)3.19882423
58modulation by symbiont of host immune response (GO:0052553)3.19407541
59positive regulation by symbiont of host defense response (GO:0052509)3.19407541
60modulation by symbiont of host defense response (GO:0052031)3.19407541
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.19407541
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.19407541
63positive regulation by organism of defense response of other organism involved in symbiotic interact3.19407541
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.18915601
65DNA topological change (GO:0006265)3.18638295
66nucleotide-excision repair, DNA gap filling (GO:0006297)3.15476397
67protein localization to kinetochore (GO:0034501)3.15126129
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.12553596
69telomere maintenance (GO:0000723)3.12346611
70DNA replication checkpoint (GO:0000076)3.08817305
71regulation of DNA damage checkpoint (GO:2000001)3.08813804
72telomere organization (GO:0032200)3.08060548
73intracellular transport of virus (GO:0075733)3.07976050
74multi-organism transport (GO:0044766)3.07976050
75multi-organism localization (GO:1902579)3.07976050
76multi-organism intracellular transport (GO:1902583)3.07976050
77transport of virus (GO:0046794)3.07976050
78DNA ligation (GO:0006266)3.06207382
79DNA unwinding involved in DNA replication (GO:0006268)3.05576272
80establishment of chromosome localization (GO:0051303)3.03221172
81macrophage activation involved in immune response (GO:0002281)3.02676855
82thrombin receptor signaling pathway (GO:0070493)3.02455245
83nuclear pore complex assembly (GO:0051292)2.99184304
84protein localization to chromosome, centromeric region (GO:0071459)2.98451095
85pericardium development (GO:0060039)2.98238963
86histone exchange (GO:0043486)2.96938234
87mitotic sister chromatid segregation (GO:0000070)2.96828742
88maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93990783
89mitotic metaphase plate congression (GO:0007080)2.93297157
90metaphase plate congression (GO:0051310)2.91840214
91regulation of granulocyte differentiation (GO:0030852)2.91349481
92negative regulation of granulocyte differentiation (GO:0030853)2.91181275
93sister chromatid segregation (GO:0000819)2.90914104
94mitochondrial calcium ion homeostasis (GO:0051560)2.90205666
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88289257
96interferon-gamma production (GO:0032609)2.86443890
97protein K6-linked ubiquitination (GO:0085020)2.85442288
98positive regulation of erythrocyte differentiation (GO:0045648)2.85069017
99positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.84028985
100antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.83997437
101regulation of B cell receptor signaling pathway (GO:0050855)2.83550184
102positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.83508138
103cellular response to interleukin-15 (GO:0071350)2.81917607
104positive regulation of macrophage differentiation (GO:0045651)2.80425700
105positive regulation of interferon-alpha production (GO:0032727)2.80374742
106DNA catabolic process, exonucleolytic (GO:0000738)2.79897901
107cellular response to exogenous dsRNA (GO:0071360)2.79613697
108negative regulation of B cell activation (GO:0050869)2.78609376
109negative regulation of phagocytosis (GO:0050765)2.78597456
110mitotic chromosome condensation (GO:0007076)2.77940520
111ribosome assembly (GO:0042255)2.75548639
112mitotic spindle assembly checkpoint (GO:0007094)2.74824781
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74658616
114negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74658616
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74658616
116negative regulation of mitotic sister chromatid separation (GO:2000816)2.74658616
117negative regulation of sister chromatid segregation (GO:0033046)2.74658616
118lymphocyte migration (GO:0072676)2.74450697
119coronary vasculature morphogenesis (GO:0060977)2.72129671
120mitotic spindle checkpoint (GO:0071174)2.71584570
121regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.71440260
122positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.71329679
123spindle assembly checkpoint (GO:0071173)2.71208522
124negative regulation of chromosome segregation (GO:0051985)2.71063226
125DNA double-strand break processing (GO:0000729)2.70193050
126pore complex assembly (GO:0046931)2.69484446
127regulation of interferon-alpha production (GO:0032647)2.66087928
128regulation of mitotic metaphase/anaphase transition (GO:0030071)2.65998686
129regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.65998686
130regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.65921424
131regulation of DNA-dependent DNA replication (GO:0090329)2.64081323
132positive regulation of natural killer cell mediated immunity (GO:0002717)2.63789181
133recombinational repair (GO:0000725)2.63338624
134nuclear pore organization (GO:0006999)2.62786878
135centriole assembly (GO:0098534)2.62099141
136reciprocal meiotic recombination (GO:0007131)2.61609032
137reciprocal DNA recombination (GO:0035825)2.61609032
138hepatocyte apoptotic process (GO:0097284)2.61151623
139ATP-dependent chromatin remodeling (GO:0043044)2.60748101
140chromosome segregation (GO:0007059)2.59643513
141V(D)J recombination (GO:0033151)2.58244324
142regulation of mitotic sister chromatid separation (GO:0010965)2.57016705
143regulation of mitotic sister chromatid segregation (GO:0033047)2.57016705
144regulation of sister chromatid segregation (GO:0033045)2.57016705
145phosphatidylinositol dephosphorylation (GO:0046856)2.54691729
146neutrophil mediated immunity (GO:0002446)2.54524698
147cellular response to interferon-beta (GO:0035458)2.54309271
148mitotic sister chromatid cohesion (GO:0007064)2.54288310
149attachment of spindle microtubules to kinetochore (GO:0008608)2.53904385
150* DNA geometric change (GO:0032392)2.52607933
151regulation of histone H3-K9 methylation (GO:0051570)2.51997091
152double-strand break repair via homologous recombination (GO:0000724)2.51893846
153replicative senescence (GO:0090399)2.51627652
154proline biosynthetic process (GO:0006561)2.51258508
155negative regulation of multicellular organism growth (GO:0040015)2.51028892
156centriole replication (GO:0007099)2.50512203
157regulation of telomere maintenance via telomerase (GO:0032210)2.50405631
158* DNA duplex unwinding (GO:0032508)2.50188840
159base-excision repair (GO:0006284)2.49277456
160translesion synthesis (GO:0019985)2.49058138
161IMP biosynthetic process (GO:0006188)2.48539073
162* DNA recombination (GO:0006310)2.47115064
163telomere maintenance via telomerase (GO:0007004)2.46497014
164nuclear envelope organization (GO:0006998)2.45880527
165somatic hypermutation of immunoglobulin genes (GO:0016446)2.45274137
166somatic diversification of immune receptors via somatic mutation (GO:0002566)2.45274137
167regulation of double-strand break repair via homologous recombination (GO:0010569)2.44036418
168negative regulation of telomere maintenance (GO:0032205)2.42672335
169sister chromatid cohesion (GO:0007062)2.41855413
170purine deoxyribonucleotide catabolic process (GO:0009155)2.40746237
171* DNA conformation change (GO:0071103)2.39841950
172regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.38221609
173chromatin assembly or disassembly (GO:0006333)2.37803097
174RNA-dependent DNA replication (GO:0006278)2.37790810
175somatic cell DNA recombination (GO:0016444)2.37680789
176somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.37680789
177* DNA strand renaturation (GO:0000733)2.37187437
178somatic diversification of immune receptors (GO:0002200)2.36120607
179regulation of helicase activity (GO:0051095)2.35751305
180mitotic nuclear envelope disassembly (GO:0007077)2.34541745
181positive regulation of DNA-dependent DNA replication (GO:2000105)2.34536254
182histone H2A acetylation (GO:0043968)2.34513473
183spindle checkpoint (GO:0031577)2.33291181
184DNA-dependent DNA replication (GO:0006261)2.32204961
185negative regulation of cell cycle G2/M phase transition (GO:1902750)2.32058561
186T cell homeostasis (GO:0043029)2.28577733
187base-excision repair, AP site formation (GO:0006285)2.28316774
188deoxyribonucleotide biosynthetic process (GO:0009263)2.27448580
189chromosome organization (GO:0051276)2.26697440
190antigen processing and presentation via MHC class Ib (GO:0002475)13.0177974
191regulation of antigen processing and presentation of peptide antigen (GO:0002583)12.0207789
192antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)10.3211366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* E2F7_22180533_ChIP-Seq_HELA_Human9.99466740
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.80641985
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.16571778
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.13354838
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78449194
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.76022771
7* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65018308
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.64287057
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62652856
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48786461
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.19544354
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12808506
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.12391656
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.07798203
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.07162852
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04387302
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00714562
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99719818
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.94646908
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89904920
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88589335
22* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88397923
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.87241446
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.86460393
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.85132247
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84383502
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.79797380
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.76851186
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.75703401
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75364142
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.73468847
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.67384386
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66368964
34* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62982772
35RUNX_20019798_ChIP-Seq_JUKART_Human1.62481612
36FOXP3_21729870_ChIP-Seq_TREG_Human1.61357191
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60792180
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.59661322
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58685367
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.58598886
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58360835
42CIITA_25753668_ChIP-Seq_RAJI_Human1.57515785
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.57130743
44* EST1_17652178_ChIP-ChIP_JURKAT_Human1.57000114
45MYB_26560356_Chip-Seq_TH2_Human1.55879190
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53061549
47VDR_23849224_ChIP-Seq_CD4+_Human1.52779981
48* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50938536
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50626797
50SCL_19346495_ChIP-Seq_HPC-7_Human1.49991944
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49808487
52ELK1_19687146_ChIP-ChIP_HELA_Human1.48975424
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48233131
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46608811
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44693959
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43890310
57TFEB_21752829_ChIP-Seq_HELA_Human1.43349617
58SPI1_23547873_ChIP-Seq_NB4_Human1.43095011
59* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40368162
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39692027
61GATA1_22025678_ChIP-Seq_K562_Human1.39493429
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.37513230
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37103338
64BRD4_25478319_ChIP-Seq_HGPS_Human1.35162512
65* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31882471
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31119797
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30020891
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25923409
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25428404
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.25301575
71MYB_26560356_Chip-Seq_TH1_Human1.23719880
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23691126
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23691126
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23691126
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22826259
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20139383
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16948218
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15859039
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.15468789
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14781824
81EWS_26573619_Chip-Seq_HEK293_Human1.13726817
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13155628
83MYC_22102868_ChIP-Seq_BL_Human1.13012383
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.11415770
85MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10552665
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.09977936
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07781094
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05068159
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04320607
90P53_22387025_ChIP-Seq_ESCs_Mouse1.03383460
91AR_21909140_ChIP-Seq_LNCAP_Human1.02946289
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02874252
93NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02645213
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01602811
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01539306
96BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01477392
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00483726
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00256440
99MAF_26560356_Chip-Seq_TH1_Human0.99339445
100SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98558785
101MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98237550
102OCT4_18555785_Chip-Seq_ESCs_Mouse0.97666268
103ZFX_18555785_Chip-Seq_ESCs_Mouse0.97286109
104NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97137581
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96886654
106SRF_21415370_ChIP-Seq_HL-1_Mouse0.96637975
107CMYC_18555785_Chip-Seq_ESCs_Mouse0.96414742
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95231770
109NANOG_18555785_Chip-Seq_ESCs_Mouse0.94548525
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94526329
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93102071
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.92699465
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.92508208
114P300_18555785_Chip-Seq_ESCs_Mouse0.92287476
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92154231
116TTF2_22483619_ChIP-Seq_HELA_Human0.91694271
117SALL1_21062744_ChIP-ChIP_HESCs_Human0.91570986
118RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91494664
119EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91263407
120RUNX1_22412390_ChIP-Seq_EML_Mouse0.91032929
121PU1_27457419_Chip-Seq_LIVER_Mouse0.90985271
122DCP1A_22483619_ChIP-Seq_HELA_Human0.90422767
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.90245947
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90152043
125GATA3_26560356_Chip-Seq_TH2_Human0.90100663
126SOX2_18555785_Chip-Seq_ESCs_Mouse0.90064547
127ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89864048
128SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89860614
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89860614
130OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89651024
131PU_27001747_Chip-Seq_BMDM_Mouse0.89593057
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89525753
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86722432
134CLOCK_20551151_ChIP-Seq_293T_Human0.85342946
135HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84791413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology4.04240624
2MP0005377_hearing/vestibular/ear_phenot4.04240624
3MP0010094_abnormal_chromosome_stability3.89724932
4MP0008058_abnormal_DNA_repair3.79198507
5MP0008438_abnormal_cutaneous_collagen3.51393518
6MP0002396_abnormal_hematopoietic_system3.48419568
7MP0008057_abnormal_DNA_replication3.33900190
8* MP0003111_abnormal_nucleus_morphology3.10021696
9MP0003693_abnormal_embryo_hatching2.84745490
10MP0001188_hyperpigmentation2.83783856
11MP0000569_abnormal_digit_pigmentation2.70826973
12MP0001835_abnormal_antigen_presentation2.69581660
13MP0000015_abnormal_ear_pigmentation2.67237989
14MP0003077_abnormal_cell_cycle2.57052320
15MP0005174_abnormal_tail_pigmentation2.50543365
16MP0003763_abnormal_thymus_physiology2.49746540
17MP0008877_abnormal_DNA_methylation2.38129079
18MP0002102_abnormal_ear_morphology2.35393871
19MP0004808_abnormal_hematopoietic_stem2.19018649
20MP0000490_abnormal_crypts_of2.10251994
21MP0008007_abnormal_cellular_replicative2.04442828
22MP0005275_abnormal_skin_tensile2.02663379
23MP0003705_abnormal_hypodermis_morpholog1.99332356
24MP0001800_abnormal_humoral_immune1.91593492
25MP0005671_abnormal_response_to1.89476865
26MP0002398_abnormal_bone_marrow1.89119324
27MP0005387_immune_system_phenotype1.78389286
28MP0001790_abnormal_immune_system1.78389286
29MP0002095_abnormal_skin_pigmentation1.77260904
30MP0006082_CNS_inflammation1.75892672
31MP0003950_abnormal_plasma_membrane1.75387588
32MP0004957_abnormal_blastocyst_morpholog1.73693156
33MP0002420_abnormal_adaptive_immunity1.72486501
34MP0002452_abnormal_antigen_presenting1.71431643
35MP0009785_altered_susceptibility_to1.70604008
36MP0001819_abnormal_immune_cell1.70386308
37MP0000703_abnormal_thymus_morphology1.67794257
38MP0002877_abnormal_melanocyte_morpholog1.67793821
39MP0006292_abnormal_olfactory_placode1.62516173
40MP0005000_abnormal_immune_tolerance1.57913677
41MP0002723_abnormal_immune_serum1.57553563
42MP0000716_abnormal_immune_system1.52455543
43MP0009333_abnormal_splenocyte_physiolog1.48931347
44MP0002332_abnormal_exercise_endurance1.46017077
45MP0002148_abnormal_hypersensitivity_rea1.45121012
46MP0002722_abnormal_immune_system1.44173624
47MP0005025_abnormal_response_to1.43180981
48MP0003786_premature_aging1.42896408
49MP0010307_abnormal_tumor_latency1.42686120
50MP0000689_abnormal_spleen_morphology1.41715190
51MP0002419_abnormal_innate_immunity1.41708471
52MP0010352_gastrointestinal_tract_polyps1.39632068
53MP0003566_abnormal_cell_adhesion1.39499640
54MP0002429_abnormal_blood_cell1.35501302
55MP0004272_abnormal_basement_membrane1.34877320
56MP0003787_abnormal_imprinting1.34589141
57MP0003879_abnormal_hair_cell1.34256678
58MP0005075_abnormal_melanosome_morpholog1.33409896
59MP0001873_stomach_inflammation1.33152282
60MP0003436_decreased_susceptibility_to1.28856133
61MP0008932_abnormal_embryonic_tissue1.26806088
62MP0001545_abnormal_hematopoietic_system1.23823270
63MP0005397_hematopoietic_system_phenotyp1.23823270
64MP0000685_abnormal_immune_system1.20525571
65MP0005623_abnormal_meninges_morphology1.19985459
66MP0002405_respiratory_system_inflammati1.17339789
67MP0002019_abnormal_tumor_incidence1.14983634
68MP0001986_abnormal_taste_sensitivity1.11603839
69MP0002998_abnormal_bone_remodeling1.11382331
70MP0000858_altered_metastatic_potential1.11198956
71MP0005360_urolithiasis1.09244372
72MP0005464_abnormal_platelet_physiology1.05483768
73MP0000313_abnormal_cell_death1.03882259
74MP0002210_abnormal_sex_determination1.02281524
75MP0003279_aneurysm1.00376290
76MP0002166_altered_tumor_susceptibility0.99565047
77MP0001186_pigmentation_phenotype0.99405128
78MP0000343_altered_response_to0.99313582
79MP0002006_tumorigenesis0.99229238
80MP0010155_abnormal_intestine_physiology0.99117860
81MP0008789_abnormal_olfactory_epithelium0.97071238
82MP0001929_abnormal_gametogenesis0.95299079
83MP0003941_abnormal_skin_development0.93745282
84MP0003866_abnormal_defecation0.93207561
85* MP0000350_abnormal_cell_proliferation0.93139786
86MP0003724_increased_susceptibility_to0.92723976
87MP0000371_diluted_coat_color0.92501760
88MP0009250_abnormal_appendicular_skeleto0.92321409
89MP0002060_abnormal_skin_morphology0.91647104
90MP0003828_pulmonary_edema0.91379872
91MP0002009_preneoplasia0.91264790
92MP0006054_spinal_hemorrhage0.90727409
93MP0002075_abnormal_coat/hair_pigmentati0.90519512
94MP0005023_abnormal_wound_healing0.89864289
95MP0010368_abnormal_lymphatic_system0.86686302
96MP0001958_emphysema0.85175206
97MP0005409_darkened_coat_color0.84911413
98MP0001119_abnormal_female_reproductive0.83489565
99MP0000465_gastrointestinal_hemorrhage0.82945353
100MP0003091_abnormal_cell_migration0.82901269
101MP0002277_abnormal_respiratory_mucosa0.82557990
102MP0009764_decreased_sensitivity_to0.82235842
103MP0004381_abnormal_hair_follicle0.81684590
104MP0005171_absent_coat_pigmentation0.80540671
105MP0002086_abnormal_extraembryonic_tissu0.78419011
106MP0005165_increased_susceptibility_to0.78066166
107MP0001243_abnormal_dermal_layer0.77215383
108MP0001845_abnormal_inflammatory_respons0.75967994
109MP0001879_abnormal_lymphatic_vessel0.75730279
110MP0001145_abnormal_male_reproductive0.75365700
111MP0005408_hypopigmentation0.74841411
112MP0003121_genomic_imprinting0.74612333
113MP0005645_abnormal_hypothalamus_physiol0.73216833
114MP0005394_taste/olfaction_phenotype0.73124507
115MP0005499_abnormal_olfactory_system0.73124507
116MP0001853_heart_inflammation0.72655788
117MP0000372_irregular_coat_pigmentation0.72059394
118MP0002933_joint_inflammation0.71553398
119MP0001542_abnormal_bone_strength0.70148921
120MP0008469_abnormal_protein_level0.69301316
121MP0000653_abnormal_sex_gland0.68720848
122MP0003698_abnormal_male_reproductive0.67741033
123MP0002132_abnormal_respiratory_system0.67206099
124MP0003448_altered_tumor_morphology0.67001484
125MP0003943_abnormal_hepatobiliary_system0.66646020
126MP0005389_reproductive_system_phenotype0.66407607
127MP0003795_abnormal_bone_structure0.66132386
128MP0002160_abnormal_reproductive_system0.65905604
129MP0005257_abnormal_intraocular_pressure0.65713649
130MP0009697_abnormal_copulation0.65352816
131MP0003300_gastrointestinal_ulcer0.64904310
132MP0004134_abnormal_chest_morphology0.64236908
133MP0001919_abnormal_reproductive_system0.63902712
134MP0004084_abnormal_cardiac_muscle0.63853094
135MP0003183_abnormal_peptide_metabolism0.63652268
136MP0008995_early_reproductive_senescence0.63321847
137MP0008260_abnormal_autophagy0.62959729
138MP0003221_abnormal_cardiomyocyte_apopto0.62949682
139MP0001727_abnormal_embryo_implantation0.62876357
140MP0001533_abnormal_skeleton_physiology0.61591399
141MP0004947_skin_inflammation0.61010279
142MP0005451_abnormal_body_composition0.60562704
143MP0005410_abnormal_fertilization0.59313111
144MP0000678_abnormal_parathyroid_gland0.59250862

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)7.14726885
2Chromosomal breakage induced by crosslinking agents (HP:0003221)6.82194276
3Chromsome breakage (HP:0040012)6.57528119
4Abnormality of the nasal mucosa (HP:0000433)6.20531428
5Chronic sinusitis (HP:0011109)6.20243612
6Reduced subcutaneous adipose tissue (HP:0003758)6.14303162
7Muscle fiber atrophy (HP:0100295)5.96061317
8Achilles tendon contracture (HP:0001771)5.86922222
9Large eyes (HP:0001090)5.84372266
10Abnormality of the Achilles tendon (HP:0005109)5.26139140
11Atrioventricular block (HP:0001678)5.03052333
12Shawl scrotum (HP:0000049)4.76487619
13Flat capital femoral epiphysis (HP:0003370)4.67453955
14Elbow flexion contracture (HP:0002987)4.52770106
15Large earlobe (HP:0009748)4.43306170
16Basal ganglia calcification (HP:0002135)4.12898429
17Aplasia/Hypoplasia of the uvula (HP:0010293)4.12760000
18Abnormality of chromosome stability (HP:0003220)4.12007654
19Increased IgM level (HP:0003496)3.96038064
20Abnormality of the preputium (HP:0100587)3.95661278
21Meckel diverticulum (HP:0002245)3.83973529
22Trismus (HP:0000211)3.71653435
23Abnormality of the ileum (HP:0001549)3.70469918
24Flexion contracture of toe (HP:0005830)3.69579105
25Joint contractures involving the joints of the feet (HP:0100492)3.69579105
26Duplicated collecting system (HP:0000081)3.54761527
27Esophageal atresia (HP:0002032)3.46496870
28Clubbing of toes (HP:0100760)3.39164227
29Abnormality of DNA repair (HP:0003254)3.32703072
30Bronchitis (HP:0012387)3.31410002
31Hypergammaglobulinemia (HP:0010702)3.29394159
32Prominent nose (HP:0000448)3.27938763
33Abnormality of the renal collecting system (HP:0004742)3.21907722
34Abnormality of the carotid arteries (HP:0005344)3.14906280
35Emphysema (HP:0002097)3.10777431
36Patchy hypopigmentation of hair (HP:0011365)3.10639595
37Ectopia lentis (HP:0001083)3.08771206
38Ectopic kidney (HP:0000086)3.00294750
39Myelodysplasia (HP:0002863)2.92386801
40Duodenal stenosis (HP:0100867)2.92081070
41Small intestinal stenosis (HP:0012848)2.92081070
42Deep philtrum (HP:0002002)2.90364601
43Prostate neoplasm (HP:0100787)2.86234563
44Overlapping toe (HP:0001845)2.84560299
45Bone marrow hypocellularity (HP:0005528)2.78507731
46Reticulocytopenia (HP:0001896)2.77480599
47Abnormality of macular pigmentation (HP:0008002)2.74142188
48Long toe (HP:0010511)2.73088644
49Abnormality of the prostate (HP:0008775)2.68119530
50Heart block (HP:0012722)2.68069340
51Abnormal atrioventricular conduction (HP:0005150)2.66402638
52Erythema (HP:0010783)2.64885299
53Blepharitis (HP:0000498)2.64207937
54Hypoproteinemia (HP:0003075)2.54004459
55Abnormality of the fingertips (HP:0001211)2.53480836
56Birth length less than 3rd percentile (HP:0003561)2.51706654
57Beaking of vertebral bodies (HP:0004568)2.43078511
58Agnosia (HP:0010524)2.41685432
59Recurrent viral infections (HP:0004429)2.40188669
60Respiratory difficulties (HP:0002880)2.38083443
61Acute lymphatic leukemia (HP:0006721)2.37124447
62Optic neuritis (HP:0100653)2.37080735
63Retrobulbar optic neuritis (HP:0100654)2.37080735
64Proximal placement of thumb (HP:0009623)2.36424308
65Recurrent abscess formation (HP:0002722)2.34588268
66Subacute progressive viral hepatitis (HP:0006572)2.34329183
67IgM deficiency (HP:0002850)2.34172544
68Premature rupture of membranes (HP:0001788)2.32375440
69Aplastic anemia (HP:0001915)2.29164408
70Sloping forehead (HP:0000340)2.29063263
71Hypertriglyceridemia (HP:0002155)2.28578095
72Meningitis (HP:0001287)2.27970715
73T lymphocytopenia (HP:0005403)2.26458012
74Deviation of the thumb (HP:0009603)2.25600783
75Abnormality of the basal ganglia (HP:0002134)2.25509122
76Short thumb (HP:0009778)2.25345323
77Abnormality of the duodenum (HP:0002246)2.24281522
78Recurrent bronchitis (HP:0002837)2.23529507
79Trigonocephaly (HP:0000243)2.22585609
80Abnormality of T cell number (HP:0011839)2.20641611
81B lymphocytopenia (HP:0010976)2.20139207
82Abnormality of B cell number (HP:0010975)2.20139207
83Microcytic anemia (HP:0001935)2.18176304
84Lymphoma (HP:0002665)2.17764789
85Upper motor neuron abnormality (HP:0002127)2.17144901
86Gastrointestinal atresia (HP:0002589)2.17000083
87Chronic obstructive pulmonary disease (HP:0006510)2.16063814
88Obstructive lung disease (HP:0006536)2.16063814
89Thrombocytosis (HP:0001894)2.13414035
90Upper limb muscle weakness (HP:0003484)2.12653711
91Nephroblastoma (Wilms tumor) (HP:0002667)2.12433786
92Optic nerve coloboma (HP:0000588)2.10443637
93Camptodactyly of toe (HP:0001836)2.10065685
94Medulloblastoma (HP:0002885)2.09669633
95Abnormal delayed hypersensitivity skin test (HP:0002963)2.09061439
96Panhypogammaglobulinemia (HP:0003139)2.08128413
97Renal cortical cysts (HP:0000803)2.05544398
98Mesomelia (HP:0003027)2.05491223
99Absent thumb (HP:0009777)2.05256454
100Recurrent fungal infections (HP:0002841)2.04935931
101Leukopenia (HP:0001882)2.04575241
102Myositis (HP:0100614)2.03997083
103Eczematoid dermatitis (HP:0000976)2.00954472
104Rib fusion (HP:0000902)2.00161207
105Abnormality of chromosome segregation (HP:0002916)1.98336466
106Mediastinal lymphadenopathy (HP:0100721)1.98264470
10711 pairs of ribs (HP:0000878)1.98256258
108Volvulus (HP:0002580)1.98109466
109Axonal loss (HP:0003447)1.97818245
110Congenital stationary night blindness (HP:0007642)1.96802024
111Premature graying of hair (HP:0002216)1.96372562
112Agammaglobulinemia (HP:0004432)1.95477904
113Triphalangeal thumb (HP:0001199)1.95111314
114Embryonal renal neoplasm (HP:0011794)1.95101013
115Abnormality of T cells (HP:0002843)1.93212824
116Spondylolisthesis (HP:0003302)1.93034287
117Vacuolated lymphocytes (HP:0001922)1.92033696
118Long clavicles (HP:0000890)1.89065647
119Abnormal hair whorl (HP:0010721)1.88801866
120Midline defect of the nose (HP:0004122)1.88674827
121Autoimmune hemolytic anemia (HP:0001890)1.88663507
122Large for gestational age (HP:0001520)1.87965883
123Acute myeloid leukemia (HP:0004808)1.86862572
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86122902
125Abnormality of cells of the lymphoid lineage (HP:0012140)1.85522356
126Arachnodactyly (HP:0001166)1.84871859
127Lymphopenia (HP:0001888)1.84293805
128Bone pain (HP:0002653)1.83712750
129Keratoconjunctivitis sicca (HP:0001097)1.80978867
130Tracheoesophageal fistula (HP:0002575)1.80443038
131Recurrent pneumonia (HP:0006532)1.80269594
132Type I transferrin isoform profile (HP:0003642)1.80044342
133IgG deficiency (HP:0004315)1.79847350
134Recurrent cutaneous fungal infections (HP:0011370)1.79653214
135Chronic mucocutaneous candidiasis (HP:0002728)1.79653214
136Eosinophilia (HP:0001880)1.77743184
137Aortic dissection (HP:0002647)1.76278671
138Encephalitis (HP:0002383)1.75035709
139Granulocytopenia (HP:0001913)1.73138509
140Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.71566132
141Oligohydramnios (HP:0001562)1.70312329
142Chronic otitis media (HP:0000389)1.69428494
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69141443
144Recurrent sinusitis (HP:0011108)1.68866558
145Microvesicular hepatic steatosis (HP:0001414)1.68256742
146Abnormality of T cell physiology (HP:0011840)1.67995574
147Abnormality of the common coagulation pathway (HP:0010990)1.67840088
148Keratoconjunctivitis (HP:0001096)1.67813888
149Recurrent bacterial skin infections (HP:0005406)1.67334031
150Orchitis (HP:0100796)1.65994187
151Chronic diarrhea (HP:0002028)1.65695269
152High pitched voice (HP:0001620)1.63970109
153Abnormality of midbrain morphology (HP:0002418)1.63857400
154Molar tooth sign on MRI (HP:0002419)1.63857400
155Osteolytic defects of the phalanges of the hand (HP:0009771)1.63760786
156Osteolytic defects of the hand bones (HP:0009699)1.63760786
157Cutaneous melanoma (HP:0012056)1.63262216
158Impulsivity (HP:0100710)1.61218685
159Duplication of thumb phalanx (HP:0009942)1.60819205
160Absent frontal sinuses (HP:0002688)1.58528905
161Arteriovenous malformation (HP:0100026)1.57208681
162Vasculitis (HP:0002633)1.56841459
163IgA deficiency (HP:0002720)1.56518031
164Elevated erythrocyte sedimentation rate (HP:0003565)1.56458283
165Abnormal spermatogenesis (HP:0008669)1.56303468
166Patellar aplasia (HP:0006443)1.54806192
167Sparse eyelashes (HP:0000653)1.53103224
168Short middle phalanx of the 5th finger (HP:0004220)1.52618552
169Bronchiectasis (HP:0002110)1.50457724
170Protrusio acetabuli (HP:0003179)1.47881430
171Arthrogryposis multiplex congenita (HP:0002804)1.47533850
172Follicular hyperkeratosis (HP:0007502)1.45209549
173Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.44345428
174Viral hepatitis (HP:0006562)1.44331852
175Ankle contracture (HP:0006466)1.44311746
176Long eyelashes (HP:0000527)1.44206644
177Severe visual impairment (HP:0001141)1.43953085
178Acute hepatic failure (HP:0006554)1.43821735
179Abnormality of the antihelix (HP:0009738)1.42245925
180Micronodular cirrhosis (HP:0001413)1.40746350
181Abnormality of macrophages (HP:0004311)1.40660583
182Wide nose (HP:0000445)1.38735724
183Skin ulcer (HP:0200042)1.36936462
184Aortic aneurysm (HP:0004942)1.35903697
185Hepatitis (HP:0012115)1.34839951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR26.45479240
2MOS6.11420168
3GRK75.78816109
4TXK3.31301917
5ZAK3.02216740
6CDC73.01259284
7SRPK12.87174506
8MAP3K102.81163255
9CCNB12.80172002
10GRK52.74397647
11MAP4K12.71297991
12STK162.63230826
13PTK22.31626847
14IRAK42.15611213
15TEC2.07020689
16EIF2AK22.05330192
17NEK22.01056987
18IRAK32.01056272
19BLK1.99240371
20ATR1.96615393
21MAP3K141.90102348
22PASK1.84096638
23MKNK11.71872422
24YES11.68880102
25TTK1.68061193
26MST41.64720840
27VRK11.61513403
28CLK11.60334761
29BRSK21.54262855
30GRK11.53055142
31BTK1.42793774
32TRIM281.41543738
33NUAK11.40409545
34BUB11.40191040
35CASK1.37252922
36MKNK21.36856948
37PBK1.33224799
38PLK11.32691167
39JAK31.31037174
40WEE11.29437353
41AURKB1.25395555
42KIT1.25121951
43BRD41.24703428
44NEK11.24371231
45EIF2AK31.21889493
46NME21.21292095
47SYK1.17801115
48CDK71.16753273
49NEK91.14161440
50ITK1.13074774
51PLK31.11660180
52CDK121.11447753
53DMPK1.11132376
54SIK31.09698249
55MAP3K121.08587324
56STK41.05606151
57RAF11.04140398
58LRRK21.04072500
59ERBB31.04011677
60EIF2AK11.03676586
61ERBB41.02893734
62TSSK61.01542559
63STK101.00189703
64CHEK10.99792839
65TLK10.99518201
66ATM0.99315145
67LYN0.97656487
68CDK80.97447249
69PLK40.96801097
70TYK20.96544632
71PIM10.95625352
72BMPR20.95272835
73BRSK10.93552724
74CHEK20.92038411
75IKBKE0.91757712
76BCR0.89744025
77DYRK30.89358478
78TRPM70.89059718
79CHUK0.88428279
80ZAP700.85847602
81SCYL20.83931607
82TAOK30.83845039
83LCK0.82360821
84PAK40.82310644
85IKBKB0.80770459
86MYLK0.80432369
87CDK40.78459000
88TNK20.76634097
89CSF1R0.75291180
90MAPKAPK20.74267440
91ACVR1B0.73979622
92JAK10.73177656
93FES0.71986966
94HCK0.70504927
95RPS6KA40.68037323
96ILK0.67812949
97BMPR1B0.60207492
98CDK10.60151788
99MARK30.59570737
100ADRBK10.58654287
101CDK20.57661851
102RPS6KB10.57116605
103ABL10.56982908
104TESK20.55332103
105JAK20.55157973
106CDK30.55058611
107SIK20.54270709
108PIK3CG0.53802654
109TTN0.52718063
110EEF2K0.52089235
111PDGFRA0.51011258
112MAPK130.49871985
113NLK0.49501716
114MST1R0.48980487
115IRAK10.47601586
116STK240.47569777
117PAK10.47269193
118CDK90.45945424
119IGF1R0.45798097
120RPS6KA60.44544264
121PRKCD0.43326984
122STK30.42559170
123CSNK2A10.42491537
124PDK20.42245153
125CSNK2A20.40924897
126RPS6KA50.40808790
127MAP3K30.38523225
128DDR20.38504275
129TBK10.37618294
130TESK10.37204478
131TAOK20.37175745
132MAPK110.37023391
133PRKDC0.36935411
134RIPK40.36446264
135MAPK140.36406718
136CSK0.36115065
137PRPF4B0.35921573
138AKT10.35309510
139AURKA0.35308268
140CDK60.34183286
141INSR0.33370929
142MAP3K130.32499090
143KDR0.31714741
144MAP3K80.30327668
145PLK20.29808407
146FLT30.26184514
147GRK60.25114105
148TAF10.24915617
149ROCK20.24203105

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.03428294
2Mismatch repair_Homo sapiens_hsa034303.78516326
3Homologous recombination_Homo sapiens_hsa034403.42457564
4Fanconi anemia pathway_Homo sapiens_hsa034603.15428903
5Base excision repair_Homo sapiens_hsa034102.91653879
6Non-homologous end-joining_Homo sapiens_hsa034502.53224891
7Nucleotide excision repair_Homo sapiens_hsa034202.40511548
8Primary immunodeficiency_Homo sapiens_hsa053402.12903718
9Cell cycle_Homo sapiens_hsa041102.04566558
10Spliceosome_Homo sapiens_hsa030401.97398109
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.96345629
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93109911
13One carbon pool by folate_Homo sapiens_hsa006701.93107917
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.87868088
15ECM-receptor interaction_Homo sapiens_hsa045121.79991810
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61207879
17Measles_Homo sapiens_hsa051621.58810278
18Dilated cardiomyopathy_Homo sapiens_hsa054141.57758641
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.57551548
20Basal transcription factors_Homo sapiens_hsa030221.56324641
21ABC transporters_Homo sapiens_hsa020101.55049115
22Hematopoietic cell lineage_Homo sapiens_hsa046401.54666562
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53681086
24RNA degradation_Homo sapiens_hsa030181.52218186
25p53 signaling pathway_Homo sapiens_hsa041151.49402069
26Pyrimidine metabolism_Homo sapiens_hsa002401.48375516
27RNA transport_Homo sapiens_hsa030131.46192436
28mRNA surveillance pathway_Homo sapiens_hsa030151.43268820
29Herpes simplex infection_Homo sapiens_hsa051681.33803843
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32781778
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.31863553
32RNA polymerase_Homo sapiens_hsa030201.29292922
33Graft-versus-host disease_Homo sapiens_hsa053321.27050716
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24086663
35Focal adhesion_Homo sapiens_hsa045101.20735685
36Antigen processing and presentation_Homo sapiens_hsa046121.20050115
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12880158
38Epstein-Barr virus infection_Homo sapiens_hsa051691.08617892
39Leishmaniasis_Homo sapiens_hsa051401.08067097
40Purine metabolism_Homo sapiens_hsa002301.03630303
41Allograft rejection_Homo sapiens_hsa053301.02609790
42Systemic lupus erythematosus_Homo sapiens_hsa053221.01297481
43T cell receptor signaling pathway_Homo sapiens_hsa046601.00174300
44B cell receptor signaling pathway_Homo sapiens_hsa046620.99121913
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98100810
46Legionellosis_Homo sapiens_hsa051340.98028800
47beta-Alanine metabolism_Homo sapiens_hsa004100.96483622
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95353214
49Viral carcinogenesis_Homo sapiens_hsa052030.94635093
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94567919
51Protein export_Homo sapiens_hsa030600.94017363
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93343630
53Autoimmune thyroid disease_Homo sapiens_hsa053200.89986259
54Influenza A_Homo sapiens_hsa051640.89620236
55Proteasome_Homo sapiens_hsa030500.89144793
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87826456
57HTLV-I infection_Homo sapiens_hsa051660.85496644
58Phototransduction_Homo sapiens_hsa047440.83946757
59Apoptosis_Homo sapiens_hsa042100.83864061
60Osteoclast differentiation_Homo sapiens_hsa043800.83775105
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.81098965
62Asthma_Homo sapiens_hsa053100.81039338
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79386163
64Inositol phosphate metabolism_Homo sapiens_hsa005620.76570672
65Other glycan degradation_Homo sapiens_hsa005110.76019166
66Hepatitis B_Homo sapiens_hsa051610.73160948
67Proteoglycans in cancer_Homo sapiens_hsa052050.72354499
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71414799
69Type I diabetes mellitus_Homo sapiens_hsa049400.71302268
70African trypanosomiasis_Homo sapiens_hsa051430.68951301
71Sulfur metabolism_Homo sapiens_hsa009200.68687056
72Small cell lung cancer_Homo sapiens_hsa052220.67020351
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66759466
74Tuberculosis_Homo sapiens_hsa051520.63372638
75MicroRNAs in cancer_Homo sapiens_hsa052060.62390660
76Toxoplasmosis_Homo sapiens_hsa051450.62352725
77N-Glycan biosynthesis_Homo sapiens_hsa005100.61382833
78Viral myocarditis_Homo sapiens_hsa054160.61320089
79Chemokine signaling pathway_Homo sapiens_hsa040620.60399792
80TNF signaling pathway_Homo sapiens_hsa046680.60143629
81Salmonella infection_Homo sapiens_hsa051320.59765488
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59333926
83Alcoholism_Homo sapiens_hsa050340.56413352
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56009657
85Protein digestion and absorption_Homo sapiens_hsa049740.54194976
86Amoebiasis_Homo sapiens_hsa051460.52999269
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52405049
88Histidine metabolism_Homo sapiens_hsa003400.51790381
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51033239
90Malaria_Homo sapiens_hsa051440.50711356
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50169339
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49902187
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.49283100
94Rheumatoid arthritis_Homo sapiens_hsa053230.48905689
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48183865
96Ribosome_Homo sapiens_hsa030100.47971518
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47585420
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46511256
99Chronic myeloid leukemia_Homo sapiens_hsa052200.45434770
100Adherens junction_Homo sapiens_hsa045200.44308019
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44260504
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43049390
103Colorectal cancer_Homo sapiens_hsa052100.42102663
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41771714
105Mineral absorption_Homo sapiens_hsa049780.41725224
106Pertussis_Homo sapiens_hsa051330.41078302
107Sphingolipid metabolism_Homo sapiens_hsa006000.40740198
108Pentose phosphate pathway_Homo sapiens_hsa000300.40624967
109Pancreatic cancer_Homo sapiens_hsa052120.39682485
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38496834
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37460064
112Arginine and proline metabolism_Homo sapiens_hsa003300.37427543
113Shigellosis_Homo sapiens_hsa051310.36976478
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36669892
115Arachidonic acid metabolism_Homo sapiens_hsa005900.34316437
116Oocyte meiosis_Homo sapiens_hsa041140.34017701
117Acute myeloid leukemia_Homo sapiens_hsa052210.32951741
118Phagosome_Homo sapiens_hsa041450.32775196
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32492832
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31055020
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30644604
122Pathways in cancer_Homo sapiens_hsa052000.30092675
123Notch signaling pathway_Homo sapiens_hsa043300.30002013
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.29849792
125Non-small cell lung cancer_Homo sapiens_hsa052230.29402267
126Platelet activation_Homo sapiens_hsa046110.27967278
127FoxO signaling pathway_Homo sapiens_hsa040680.26754038
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26443031

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