RECQL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.32097964
2GDP-mannose metabolic process (GO:0019673)6.62732222
3replication fork processing (GO:0031297)6.54353497
4transcription from mitochondrial promoter (GO:0006390)6.45194612
5embryonic process involved in female pregnancy (GO:0060136)6.26653216
6proline metabolic process (GO:0006560)6.13241227
7DNA deamination (GO:0045006)5.90030661
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.79595344
9negative regulation of cell aging (GO:0090344)5.46050870
10DNA replication checkpoint (GO:0000076)5.29912414
11establishment of apical/basal cell polarity (GO:0035089)5.23129767
12somatic diversification of immune receptors via somatic mutation (GO:0002566)5.21679460
13somatic hypermutation of immunoglobulin genes (GO:0016446)5.21679460
14positive regulation of protein homooligomerization (GO:0032464)5.20336032
15regulation of integrin activation (GO:0033623)4.98225792
16mitochondrial DNA metabolic process (GO:0032042)4.86248324
17regulation of translational fidelity (GO:0006450)4.78244769
18mitotic G1 DNA damage checkpoint (GO:0031571)4.76736774
19mitotic chromosome condensation (GO:0007076)4.73898506
20telomere maintenance via semi-conservative replication (GO:0032201)4.71375339
21adenine nucleotide transport (GO:0051503)4.70423495
22oxidative demethylation (GO:0070989)4.52807435
23formation of translation preinitiation complex (GO:0001731)4.50398661
24establishment or maintenance of monopolar cell polarity (GO:0061339)4.46475631
25establishment of monopolar cell polarity (GO:0061162)4.46475631
26negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.44158434
27regulation of protein homooligomerization (GO:0032462)4.37832297
28viral mRNA export from host cell nucleus (GO:0046784)4.35898341
29adenosine receptor signaling pathway (GO:0001973)4.30448114
30spliceosomal tri-snRNP complex assembly (GO:0000244)4.30179771
31DNA strand elongation involved in DNA replication (GO:0006271)4.27073543
32purine ribonucleotide transport (GO:0015868)4.24489127
33positive regulation of mitotic sister chromatid separation (GO:1901970)4.24436516
34positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.24436516
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.24436516
36base-excision repair (GO:0006284)4.21042437
37G1 DNA damage checkpoint (GO:0044783)4.20442623
38mitotic G1/S transition checkpoint (GO:0044819)4.18905709
39folic acid metabolic process (GO:0046655)4.18579487
40nucleotide-excision repair, DNA gap filling (GO:0006297)4.16521982
41mRNA cleavage (GO:0006379)4.15223706
42poly(A)+ mRNA export from nucleus (GO:0016973)4.15209091
43UV protection (GO:0009650)4.12993776
44meiotic chromosome segregation (GO:0045132)4.07686810
45rRNA methylation (GO:0031167)4.05188329
46DNA strand elongation (GO:0022616)4.02870815
47negative regulation of mRNA processing (GO:0050686)4.01833352
48dosage compensation (GO:0007549)4.01804634
49histone phosphorylation (GO:0016572)4.00376420
50regulation of sister chromatid cohesion (GO:0007063)3.99607958
51telomere maintenance via recombination (GO:0000722)3.93634095
52mitotic sister chromatid segregation (GO:0000070)3.93262328
53ribosomal small subunit biogenesis (GO:0042274)3.86592004
54regulation of RNA export from nucleus (GO:0046831)3.85355804
55positive regulation of chromosome segregation (GO:0051984)3.78210706
56DNA topological change (GO:0006265)3.75903229
57negative regulation of cell cycle arrest (GO:0071157)3.75200496
58* DNA duplex unwinding (GO:0032508)3.74193942
59rRNA modification (GO:0000154)3.71301810
60kinetochore assembly (GO:0051382)3.71236496
61regulation of mammary gland epithelial cell proliferation (GO:0033599)3.70764145
62regulation of double-strand break repair via homologous recombination (GO:0010569)3.69780226
63peptidyl-glutamic acid carboxylation (GO:0017187)3.69768116
64protein carboxylation (GO:0018214)3.69768116
65purine nucleotide transport (GO:0015865)3.68893085
66termination of RNA polymerase II transcription (GO:0006369)3.68545841
67embryonic placenta development (GO:0001892)3.66202438
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.64789610
69histone H4-K12 acetylation (GO:0043983)3.62603508
70negative regulation of RNA splicing (GO:0033119)3.61881496
71regulation of posttranscriptional gene silencing (GO:0060147)3.61359533
72regulation of gene silencing by miRNA (GO:0060964)3.61359533
73regulation of gene silencing by RNA (GO:0060966)3.61359533
74G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.60307893
75double-strand break repair via nonhomologous end joining (GO:0006303)3.60297592
76non-recombinational repair (GO:0000726)3.60297592
77DNA double-strand break processing (GO:0000729)3.60096396
78negative regulation of JAK-STAT cascade (GO:0046426)3.57877148
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.56961265
80mitotic recombination (GO:0006312)3.55257893
81protein localization to chromosome, centromeric region (GO:0071459)3.53686252
82kinetochore organization (GO:0051383)3.52218241
83* DNA geometric change (GO:0032392)3.52147902
84regulation of double-strand break repair (GO:2000779)3.52098770
85sister chromatid segregation (GO:0000819)3.46629741
86DNA integration (GO:0015074)3.46316119
87nucleotide-sugar biosynthetic process (GO:0009226)3.46246700
88negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.45076289
89nuclear pore complex assembly (GO:0051292)3.40959872
90telomere maintenance via telomere lengthening (GO:0010833)3.37390247
91protein retention in ER lumen (GO:0006621)3.36534804
92regulation of DNA damage checkpoint (GO:2000001)3.36401495
93planar cell polarity pathway involved in neural tube closure (GO:0090179)3.35596643
94trophectodermal cell differentiation (GO:0001829)3.35533273
95negative regulation of mRNA metabolic process (GO:1903312)3.35508027
96mitochondrial RNA metabolic process (GO:0000959)3.35484563
97positive regulation by host of viral transcription (GO:0043923)3.30566242
98maturation of 5.8S rRNA (GO:0000460)3.30352096
99nucleoside transmembrane transport (GO:1901642)3.30213881
100DNA unwinding involved in DNA replication (GO:0006268)3.22786775
101regulation of nuclear cell cycle DNA replication (GO:0033262)3.22713418
102lens fiber cell differentiation (GO:0070306)3.22224350
103negative regulation of fatty acid biosynthetic process (GO:0045717)3.21172715
104positive regulation of protein oligomerization (GO:0032461)3.21059506
105pre-miRNA processing (GO:0031054)3.20559745
106base-excision repair, AP site formation (GO:0006285)3.19759750
107mitotic nuclear envelope disassembly (GO:0007077)3.19676143
108DNA ligation (GO:0006266)3.19097036
109positive regulation of protein kinase C signaling (GO:0090037)3.18859151
110regulation of skeletal muscle contraction (GO:0014819)3.18174440
111pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.17645556
112apoptotic process involved in morphogenesis (GO:0060561)3.17418279
113cellular response to ATP (GO:0071318)3.17087846
114regulation of cell aging (GO:0090342)3.15956140
115maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.14491677
116nuclear envelope organization (GO:0006998)3.14182300
117chromosome condensation (GO:0030261)3.13563861
118* DNA conformation change (GO:0071103)3.12888384
119semaphorin-plexin signaling pathway (GO:0071526)3.12507510
120glutamine family amino acid biosynthetic process (GO:0009084)3.12287104
121embryonic camera-type eye development (GO:0031076)3.10665658
122protein localization to kinetochore (GO:0034501)3.08659227
123mannose metabolic process (GO:0006013)3.08226190
124sensory perception of taste (GO:0050909)3.08039943
125DNA replication initiation (GO:0006270)3.07119592
126negative regulation of Ras GTPase activity (GO:0034261)3.06437983
127activation of Rac GTPase activity (GO:0032863)3.04363363
128mRNA export from nucleus (GO:0006406)3.03283200
129resolution of meiotic recombination intermediates (GO:0000712)3.02445737
130tRNA modification (GO:0006400)3.01912907
131heterochromatin organization (GO:0070828)3.00430849
132determination of adult lifespan (GO:0008340)3.00026542
133negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.96934639
134L-serine metabolic process (GO:0006563)2.95323724
135nuclear envelope disassembly (GO:0051081)2.95287462
136membrane disassembly (GO:0030397)2.95287462
137positive regulation of developmental pigmentation (GO:0048087)2.94684596
138cellular response to zinc ion (GO:0071294)2.94394096
139mRNA transport (GO:0051028)2.94196504
140regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.93648838
141chromatin assembly (GO:0031497)2.92367626
142regulation of nucleobase-containing compound transport (GO:0032239)2.91788337
143nodal signaling pathway (GO:0038092)2.90308302
144regulation of protein oligomerization (GO:0032459)2.89776306
145RNA export from nucleus (GO:0006405)2.88147097
146rRNA transcription (GO:0009303)2.87843769
147nuclear pore organization (GO:0006999)2.85942471
148DNA synthesis involved in DNA repair (GO:0000731)2.83546176
149peptidyl-arginine omega-N-methylation (GO:0035247)2.82493291
150snRNA metabolic process (GO:0016073)2.82397335
151protein-DNA complex disassembly (GO:0032986)2.81337706
152nucleosome disassembly (GO:0006337)2.81337706
153nucleoside transport (GO:0015858)2.80597192
154protein insertion into membrane (GO:0051205)2.77709483
155protein complex localization (GO:0031503)2.76738873
156purinergic nucleotide receptor signaling pathway (GO:0035590)2.73645579
157positive regulation of DNA-dependent DNA replication (GO:2000105)2.67266646
158regulation of chromatin binding (GO:0035561)2.65193457
159regulation of translational elongation (GO:0006448)2.64556816
160modulation by virus of host process (GO:0019054)2.64086433
161ribonucleoprotein complex biogenesis (GO:0022613)2.61740899
162ribosome biogenesis (GO:0042254)2.60734569
163spindle assembly (GO:0051225)2.60573441
164negative regulation of cell size (GO:0045792)2.60092523
165convergent extension (GO:0060026)2.60079203
166pore complex assembly (GO:0046931)2.58618686
167melanin biosynthetic process (GO:0042438)2.56698358
168chromosome segregation (GO:0007059)2.56627362
169chromatin assembly or disassembly (GO:0006333)2.55864626
170DNA packaging (GO:0006323)2.52680330
171positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.51008782
172regulation of synapse structural plasticity (GO:0051823)2.50785597
173* DNA replication (GO:0006260)2.49986648
174nucleobase biosynthetic process (GO:0046112)2.48657122
175regulation of DNA-dependent DNA replication (GO:0090329)2.48504505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.23382665
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.56123292
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.47587246
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.04084074
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94875213
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71677187
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.64631484
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.58298563
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.58298563
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.58298563
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48670722
12* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35787385
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32561394
14VDR_21846776_ChIP-Seq_THP-1_Human2.30059632
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25489179
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18112637
17P68_20966046_ChIP-Seq_HELA_Human2.17477515
18MYC_22102868_ChIP-Seq_BL_Human2.09135501
19* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.04134269
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02142683
21KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.96304207
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.91570581
23SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.90898968
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.88631057
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85982197
26NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.85954258
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85667530
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.83168638
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78675941
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77880026
31POU5F1_16518401_ChIP-PET_MESCs_Mouse1.72613707
32TCF3_18692474_ChIP-Seq_MESCs_Mouse1.71272036
33MAF_26560356_Chip-Seq_TH2_Human1.67666735
34* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62872454
35NANOG_21062744_ChIP-ChIP_HESCs_Human1.62829804
36* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62330360
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.62087942
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.60241012
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60138674
40TCF3_18692474_ChIP-Seq_MEFs_Mouse1.59735741
41* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59226779
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58551634
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.58071646
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55312721
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54882866
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54511625
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53930764
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50661059
49MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.49919681
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48654208
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48475163
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48302402
53* XRN2_22483619_ChIP-Seq_HELA_Human1.47006248
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.46963649
55* ERG_21242973_ChIP-ChIP_JURKAT_Human1.45804902
56TCF7_22412390_ChIP-Seq_EML_Mouse1.45457535
57BCOR_27268052_Chip-Seq_Bcells_Human1.44753313
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43946645
59SMC4_20622854_ChIP-Seq_HELA_Human1.42796040
60VDR_24763502_ChIP-Seq_THP-1_Human1.42275325
61FOXP1_21924763_ChIP-Seq_HESCs_Human1.41955325
62KDM5A_27292631_Chip-Seq_BREAST_Human1.40358165
63MAF_26560356_Chip-Seq_TH1_Human1.39905195
64GABP_19822575_ChIP-Seq_HepG2_Human1.39240496
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39153548
66LXR_22292898_ChIP-Seq_THP-1_Human1.39137866
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.38647290
68E2F1_20622854_ChIP-Seq_HELA_Human1.38183038
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.38076279
70BCL6_27268052_Chip-Seq_Bcells_Human1.37508402
71PHF8_20622854_ChIP-Seq_HELA_Human1.37078065
72RARB_24833708_ChIP-Seq_LIVER_Mouse1.36232285
73DCP1A_22483619_ChIP-Seq_HELA_Human1.35567569
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34965478
75* RARA_24833708_ChIP-Seq_LIVER_Mouse1.34285851
76NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.33005193
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.32344054
78ZNF263_19887448_ChIP-Seq_K562_Human1.31589783
79TP63_17297297_ChIP-ChIP_HaCaT_Human1.30828786
80PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30572113
81CTCF_27219007_Chip-Seq_Bcells_Human1.30393038
82CREB1_26743006_Chip-Seq_LNCaP_Human1.29308978
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28792321
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28369517
85ATF3_27146783_Chip-Seq_COLON_Human1.27536538
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27319825
87NCOR1_26117541_ChIP-Seq_K562_Human1.26894362
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26164472
89* TTF2_22483619_ChIP-Seq_HELA_Human1.26124625
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25641812
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25073275
92TP53_22127205_ChIP-Seq_IMR90_Human1.23508591
93POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.23417104
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22854265
95CTCF_21964334_Chip-Seq_Bcells_Human1.22736154
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22587793
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21946491
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21784580
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21689750
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21540627
101* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20563279
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20259498
103EST1_17652178_ChIP-ChIP_JURKAT_Human1.20090484
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19610346
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19588603
106NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.18965277
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18469772
108NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17453193
109RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17352541
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16970123
111CIITA_25753668_ChIP-Seq_RAJI_Human1.16666548
112SOX2_18692474_ChIP-Seq_MESCs_Mouse1.15069444
113UTX_26944678_Chip-Seq_JUKART_Human1.14784307
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13394894
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13037456
116ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12403357
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12319906
118RACK7_27058665_Chip-Seq_MCF-7_Human1.12257129
119KDM2B_26808549_Chip-Seq_K562_Human1.12201280
120TET1_21451524_ChIP-Seq_MESCs_Mouse1.11876044
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11603789
122ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11139483
123KDM2B_26808549_Chip-Seq_DND41_Human1.10352420
124AR_21909140_ChIP-Seq_LNCAP_Human1.08872399
125EGR1_19374776_ChIP-ChIP_THP-1_Human1.08761680
126SALL1_21062744_ChIP-ChIP_HESCs_Human1.08078702
127SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07768028
128TFEB_21752829_ChIP-Seq_HELA_Human1.07492338
129MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07044845
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06840823
131OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06275785
132CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05551178
133VDR_23849224_ChIP-Seq_CD4+_Human1.05342503
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04684770
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04400362
136TP63_19390658_ChIP-ChIP_HaCaT_Human1.04197870
137NANOG_18692474_ChIP-Seq_MESCs_Mouse1.03530482
138SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01978309
139ELK3_25401928_ChIP-Seq_HUVEC_Human1.01215689
140KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00520235
141CTCF_26484167_Chip-Seq_Bcells_Mouse1.00213292
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00117041
143ETS1_21867929_ChIP-Seq_TH2_Mouse0.96739415
144PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96019484
145CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95698601
146KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93864074
147TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92013745

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.33452224
2MP0003136_yellow_coat_color4.08157486
3MP0009278_abnormal_bone_marrow3.82796346
4MP0005423_abnormal_somatic_nervous3.54687229
5MP0001986_abnormal_taste_sensitivity3.53997730
6MP0010030_abnormal_orbit_morphology3.49695791
7MP0005409_darkened_coat_color3.24742945
8MP0003111_abnormal_nucleus_morphology3.18095258
9* MP0010094_abnormal_chromosome_stability3.13219993
10MP0004233_abnormal_muscle_weight2.76793648
11MP0001188_hyperpigmentation2.69187220
12MP0003693_abnormal_embryo_hatching2.68197130
13* MP0004957_abnormal_blastocyst_morpholog2.66026664
14MP0003077_abnormal_cell_cycle2.51402521
15MP0008995_early_reproductive_senescence2.45086672
16MP0010352_gastrointestinal_tract_polyps2.42709826
17MP0002009_preneoplasia2.41721703
18MP0008058_abnormal_DNA_repair2.40530154
19MP0003890_abnormal_embryonic-extraembry2.40067462
20MP0005083_abnormal_biliary_tract2.38801227
21MP0008877_abnormal_DNA_methylation2.30780044
22MP0003786_premature_aging2.30643588
23MP0005076_abnormal_cell_differentiation2.27341650
24MP0004185_abnormal_adipocyte_glucose2.18963539
25MP0001545_abnormal_hematopoietic_system2.15274427
26MP0005397_hematopoietic_system_phenotyp2.15274427
27MP0001661_extended_life_span2.14095074
28MP0008932_abnormal_embryonic_tissue2.09210907
29MP0003283_abnormal_digestive_organ2.07123816
30MP0000751_myopathy2.02822070
31MP0002653_abnormal_ependyma_morphology1.97534240
32MP0004381_abnormal_hair_follicle1.94030064
33MP0002084_abnormal_developmental_patter1.92687555
34MP0003119_abnormal_digestive_system1.92430500
35MP0001697_abnormal_embryo_size1.89785598
36MP0001730_embryonic_growth_arrest1.83900684
37MP0004197_abnormal_fetal_growth/weight/1.82205511
38MP0004133_heterotaxia1.82186406
39MP0000350_abnormal_cell_proliferation1.81864564
40* MP0002086_abnormal_extraembryonic_tissu1.81626110
41MP0010307_abnormal_tumor_latency1.77056486
42* MP0002085_abnormal_embryonic_tissue1.74903869
43MP0005380_embryogenesis_phenotype1.74880934
44MP0001672_abnormal_embryogenesis/_devel1.74880934
45MP0000490_abnormal_crypts_of1.73339216
46MP0001293_anophthalmia1.72924577
47MP0000003_abnormal_adipose_tissue1.68661193
48MP0002249_abnormal_larynx_morphology1.54430255
49MP0010234_abnormal_vibrissa_follicle1.52810604
50MP0003453_abnormal_keratinocyte_physiol1.50209373
51MP0003567_abnormal_fetal_cardiomyocyte1.50026003
52MP0006072_abnormal_retinal_apoptosis1.48087532
53MP0003984_embryonic_growth_retardation1.43634019
54MP0000750_abnormal_muscle_regeneration1.42476708
55MP0005058_abnormal_lysosome_morphology1.41320708
56MP0002282_abnormal_trachea_morphology1.39315401
57* MP0002080_prenatal_lethality1.39041897
58MP0001348_abnormal_lacrimal_gland1.38988473
59MP0002088_abnormal_embryonic_growth/wei1.38937811
60MP0000678_abnormal_parathyroid_gland1.38037271
61MP0005330_cardiomyopathy1.35673206
62MP0005451_abnormal_body_composition1.30399430
63MP0000537_abnormal_urethra_morphology1.29693399
64MP0002877_abnormal_melanocyte_morpholog1.28950132
65MP0001849_ear_inflammation1.28887230
66MP0001346_abnormal_lacrimal_gland1.27882646
67MP0000747_muscle_weakness1.26294119
68MP0002111_abnormal_tail_morphology1.23816194
69MP0000371_diluted_coat_color1.23453149
70* MP0002019_abnormal_tumor_incidence1.21399568
71MP0001873_stomach_inflammation1.18456689
72MP0002160_abnormal_reproductive_system1.17241737
73MP0001502_abnormal_circadian_rhythm1.16962869
74MP0003806_abnormal_nucleotide_metabolis1.16634737
75MP0000313_abnormal_cell_death1.14319440
76MP0000358_abnormal_cell_content/1.12952111
77MP0003705_abnormal_hypodermis_morpholog1.12104296
78MP0000538_abnormal_urinary_bladder1.11537740
79MP0000470_abnormal_stomach_morphology1.09983075
80MP0001968_abnormal_touch/_nociception1.09501505
81MP0005075_abnormal_melanosome_morpholog1.08885590
82MP0002396_abnormal_hematopoietic_system1.07619407
83MP0003315_abnormal_perineum_morphology1.07601281
84MP0003718_maternal_effect1.05980651
85MP0005257_abnormal_intraocular_pressure1.05922768
86MP0002269_muscular_atrophy1.05324351
87MP0008007_abnormal_cellular_replicative1.04169947
88MP0000579_abnormal_nail_morphology1.04128896
89MP0000015_abnormal_ear_pigmentation1.03574684
90MP0003172_abnormal_lysosome_physiology1.03344810
91MP0000013_abnormal_adipose_tissue1.01919793
92MP0001756_abnormal_urination1.01234391
93MP0005666_abnormal_adipose_tissue1.00719906
94MP0004264_abnormal_extraembryonic_tissu0.98493287
95MP0009053_abnormal_anal_canal0.98293800
96MP0001145_abnormal_male_reproductive0.98008215
97MP0005375_adipose_tissue_phenotype0.96563949
98MP0010771_integument_phenotype0.96473373
99MP0002932_abnormal_joint_morphology0.94852918
100MP0009672_abnormal_birth_weight0.92116034
101MP0002254_reproductive_system_inflammat0.91913910
102MP0000462_abnormal_digestive_system0.91689697
103MP0004858_abnormal_nervous_system0.91153445
104MP0003656_abnormal_erythrocyte_physiolo0.90604875
105MP0002089_abnormal_postnatal_growth/wei0.89115007
106* MP0009931_abnormal_skin_appearance0.88554649
107MP0002796_impaired_skin_barrier0.88152419
108MP0001340_abnormal_eyelid_morphology0.87617439
109MP0002114_abnormal_axial_skeleton0.87017711
110MP0001216_abnormal_epidermal_layer0.86530098
111MP0002210_abnormal_sex_determination0.85935876
112MP0005501_abnormal_skin_physiology0.84097162
113MP0005621_abnormal_cell_physiology0.83888699
114MP0009333_abnormal_splenocyte_physiolog0.81346493
115MP0002697_abnormal_eye_size0.81209153
116MP0003566_abnormal_cell_adhesion0.80150525
117MP0002736_abnormal_nociception_after0.79835932
118MP0004808_abnormal_hematopoietic_stem0.77251694
119MP0005266_abnormal_metabolism0.77064722
120MP0000377_abnormal_hair_follicle0.75964485
121MP0005023_abnormal_wound_healing0.75747862
122MP0002116_abnormal_craniofacial_bone0.75600143
123MP0001664_abnormal_digestion0.75139093
124MP0000762_abnormal_tongue_morphology0.74508515
125MP0005220_abnormal_exocrine_pancreas0.74235540
126MP0001929_abnormal_gametogenesis0.73729477
127MP0000653_abnormal_sex_gland0.73581082
128* MP0003935_abnormal_craniofacial_develop0.73550273
129MP0003091_abnormal_cell_migration0.71659149
130MP0003828_pulmonary_edema0.71202104
131* MP0000432_abnormal_head_morphology0.70657942
132MP0005384_cellular_phenotype0.70648728
133MP0000639_abnormal_adrenal_gland0.70419467
134MP0003115_abnormal_respiratory_system0.70406488
135MP0002060_abnormal_skin_morphology0.69520231
136MP0008875_abnormal_xenobiotic_pharmacok0.69489429
137MP0002092_abnormal_eye_morphology0.69344162
138MP0001915_intracranial_hemorrhage0.69129858
139MP0000685_abnormal_immune_system0.67454000
140MP0002405_respiratory_system_inflammati0.66678233
141MP0009115_abnormal_fat_cell0.66301975
142MP0009703_decreased_birth_body0.64967050
143MP0000566_synostosis0.64806794
144MP0003943_abnormal_hepatobiliary_system0.64232861
145MP0000858_altered_metastatic_potential0.64029256
146MP0003123_paternal_imprinting0.63440453
147MP0000467_abnormal_esophagus_morphology0.63114241
148MP0008770_decreased_survivor_rate0.62210957
149MP0010630_abnormal_cardiac_muscle0.62138080
150* MP0003755_abnormal_palate_morphology0.61881375
151* MP0000689_abnormal_spleen_morphology0.61484542
152MP0001784_abnormal_fluid_regulation0.61464764
153MP0003699_abnormal_female_reproductive0.60579029
154MP0003861_abnormal_nervous_system0.60513418
155MP0002925_abnormal_cardiovascular_devel0.59894961
156MP0002970_abnormal_white_adipose0.59170179
157* MP0000703_abnormal_thymus_morphology0.59152485

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.53600627
2Thin bony cortex (HP:0002753)5.17211331
3Pustule (HP:0200039)5.13785646
4Concave nail (HP:0001598)4.84692766
5Hypochromic microcytic anemia (HP:0004840)4.53552968
6Tongue fasciculations (HP:0001308)4.27422879
7Alopecia of scalp (HP:0002293)4.23398085
8Increased IgM level (HP:0003496)4.10101693
9Abnormality of the intrinsic pathway (HP:0010989)4.08706587
10Dyschromatopsia (HP:0007641)3.96365818
11Muscle fibrillation (HP:0010546)3.91417924
12Hemorrhage of the eye (HP:0011885)3.90889305
13Selective tooth agenesis (HP:0001592)3.86727860
14Delayed epiphyseal ossification (HP:0002663)3.84175267
15Orthostatic hypotension (HP:0001278)3.81512108
16Intestinal atresia (HP:0011100)3.70856086
17Male infertility (HP:0003251)3.67011984
18Volvulus (HP:0002580)3.66798520
19Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.50131135
20Vertebral hypoplasia (HP:0008417)3.50131135
21Abnormal hemoglobin (HP:0011902)3.49081126
22Broad alveolar ridges (HP:0000187)3.30507835
23Akinesia (HP:0002304)3.26073208
24Abnormality of the astrocytes (HP:0100707)3.24624907
25Astrocytoma (HP:0009592)3.24624907
26Abnormality of the labia minora (HP:0012880)3.23195945
27Attenuation of retinal blood vessels (HP:0007843)3.20994452
28Abnormality of male internal genitalia (HP:0000022)3.17398145
29Thin ribs (HP:0000883)3.11276967
30Progressive external ophthalmoplegia (HP:0000590)2.96020050
31Alacrima (HP:0000522)2.95992302
32Mesangial abnormality (HP:0001966)2.95302362
33Hyperacusis (HP:0010780)2.95132842
34Ependymoma (HP:0002888)2.93528171
35Acute lymphatic leukemia (HP:0006721)2.92021409
36Hypochromic anemia (HP:0001931)2.92016847
37Abnormality of the aortic arch (HP:0012303)2.91433618
38Myopathic facies (HP:0002058)2.89260015
39Prolonged partial thromboplastin time (HP:0003645)2.83998447
40Abnormal number of incisors (HP:0011064)2.83190728
41Dysautonomia (HP:0002459)2.83154687
42Diaphragmatic weakness (HP:0009113)2.82751324
43Neoplasm of the oral cavity (HP:0100649)2.81209159
44Vertebral fusion (HP:0002948)2.78768932
45Premature skin wrinkling (HP:0100678)2.78063050
46Albinism (HP:0001022)2.75911909
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75283561
48Abnormality of the ileum (HP:0001549)2.74420565
49Progressive muscle weakness (HP:0003323)2.74169445
50Hamartoma (HP:0010566)2.71811414
51Pterygium (HP:0001059)2.71797588
52Cerebral aneurysm (HP:0004944)2.70328220
53Pancreatic islet-cell hyperplasia (HP:0004510)2.70258968
54Breast hypoplasia (HP:0003187)2.62045764
55Glioma (HP:0009733)2.60317409
56IgA deficiency (HP:0002720)2.59652996
57Spinal muscular atrophy (HP:0007269)2.57461819
58Gastrointestinal atresia (HP:0002589)2.50696641
59Large for gestational age (HP:0001520)2.49803789
60Bony spicule pigmentary retinopathy (HP:0007737)2.49399374
61Rhabdomyosarcoma (HP:0002859)2.48488425
62Atrioventricular block (HP:0001678)2.47297592
63Amniotic constriction ring (HP:0009775)2.47265598
64Abnormality of placental membranes (HP:0011409)2.47265598
65Fetal akinesia sequence (HP:0001989)2.46977443
66Short 5th finger (HP:0009237)2.45056980
67Hypotrichosis (HP:0001006)2.41967949
68Joint hemorrhage (HP:0005261)2.41714400
69Cholelithiasis (HP:0001081)2.39751773
70Decreased lacrimation (HP:0000633)2.37739755
71Flat occiput (HP:0005469)2.37548171
72* Absent radius (HP:0003974)2.32740675
73Polycythemia (HP:0001901)2.32083078
74Mucopolysacchariduria (HP:0008155)2.31344578
75Urinary glycosaminoglycan excretion (HP:0003541)2.31344578
76Hemivertebrae (HP:0002937)2.28176098
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.25570421
78Abnormality of the lower motor neuron (HP:0002366)2.24203395
79Facial diplegia (HP:0001349)2.23007200
80Microvesicular hepatic steatosis (HP:0001414)2.22366354
81Abnormality of the costochondral junction (HP:0000919)2.19803431
82Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.19145137
83Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.18939099
84Absent epiphyses (HP:0010577)2.18939099
85Slender long bone (HP:0003100)2.17381343
86Medulloblastoma (HP:0002885)2.15729050
87* Absent forearm bone (HP:0003953)2.14818706
88* Aplasia involving forearm bones (HP:0009822)2.14818706
89Neoplasm of striated muscle (HP:0009728)2.14746229
90Abnormal trabecular bone morphology (HP:0100671)2.12621401
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11706761
92External ophthalmoplegia (HP:0000544)2.10575770
93Chorioretinal atrophy (HP:0000533)2.10505655
94Impulsivity (HP:0100710)2.09688543
95Birth length less than 3rd percentile (HP:0003561)2.08497441
96Hypoplasia of the pons (HP:0012110)2.08421705
97Missing ribs (HP:0000921)2.08354524
98Abnormality of abdominal situs (HP:0011620)2.07994108
99Abdominal situs inversus (HP:0003363)2.07994108
100Hypoalbuminemia (HP:0003073)2.06615980
101Abnormal albumin level (HP:0012116)2.06615980
102Congenital stationary night blindness (HP:0007642)2.05896899
103Hypophosphatemic rickets (HP:0004912)2.05491280
104Abnormality of the anterior horn cell (HP:0006802)2.05342993
105Degeneration of anterior horn cells (HP:0002398)2.05342993
106* Patellar aplasia (HP:0006443)2.04434975
107Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04061466
108Abnormality of polysaccharide metabolism (HP:0011012)2.04061466
109Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04061466
110* Rib fusion (HP:0000902)2.03168847
111Heterotopia (HP:0002282)2.02891655
112Aplasia of the musculature (HP:0100854)2.01667314
113Broad thumb (HP:0011304)2.01562971
114Easy fatigability (HP:0003388)2.00634959
115Abnormal epiphyseal ossification (HP:0010656)2.00099875
116Hypokinesia (HP:0002375)1.99990883
117Rectal prolapse (HP:0002035)1.99025507
118Widely patent fontanelles and sutures (HP:0004492)1.98607262
119Chromsome breakage (HP:0040012)1.98359998
120Insomnia (HP:0100785)1.98165253
121Enlarged epiphyses (HP:0010580)1.97744717
122Shawl scrotum (HP:0000049)1.97575784
123Neonatal onset (HP:0003623)1.97446385
124Abnormal gallbladder morphology (HP:0012437)1.97420257
125Broad face (HP:0000283)1.96921703
126Broad distal phalanx of finger (HP:0009836)1.96881183
127Asymmetry of the thorax (HP:0001555)1.95975822
128Growth hormone excess (HP:0000845)1.95004642
129Reduced antithrombin III activity (HP:0001976)1.92902628
130Metaphyseal cupping (HP:0003021)1.92496391
131Clumsiness (HP:0002312)1.92324520
132Abnormality of the alveolar ridges (HP:0006477)1.89612729
133* Aplasia/Hypoplasia of the patella (HP:0006498)1.89532239
134Zonular cataract (HP:0010920)1.88246973
135Pointed chin (HP:0000307)1.87732394
136Generalized amyotrophy (HP:0003700)1.87228379
137Dysostosis multiplex (HP:0000943)1.87042184
138Median cleft lip (HP:0000161)1.86036048
139Flattened epiphyses (HP:0003071)1.84348936
140Reticulocytopenia (HP:0001896)1.82974990
141Abnormality of homocysteine metabolism (HP:0010919)1.82954499
142Homocystinuria (HP:0002156)1.82954499
143Proximal placement of thumb (HP:0009623)1.82783834
144Diminished movement (HP:0002374)1.82394796
145Cheilitis (HP:0100825)1.81712772
146Atresia of the external auditory canal (HP:0000413)1.81661295
147Pendular nystagmus (HP:0012043)1.81403271
148Increased nuchal translucency (HP:0010880)1.81281596
149Mask-like facies (HP:0000298)1.81188347
150Distal upper limb amyotrophy (HP:0007149)1.80324490
151Upper limb amyotrophy (HP:0009129)1.80324490
152Ragged-red muscle fibers (HP:0003200)1.80069630
153Duplication of thumb phalanx (HP:0009942)1.80034504
154Deviation of the thumb (HP:0009603)1.79977248
155Aplasia/Hypoplasia of the uvula (HP:0010293)1.79764770
156Reticulocytosis (HP:0001923)1.79717958
157* Aplasia/hypoplasia of the humerus (HP:0006507)1.79307014
158Abnormality of the pancreatic islet cells (HP:0006476)1.78700449
159Abnormality of endocrine pancreas physiology (HP:0012093)1.78700449
160Abnormality of the gallbladder (HP:0005264)1.78008278
161Obsessive-compulsive behavior (HP:0000722)1.78001014
162Nephroblastoma (Wilms tumor) (HP:0002667)1.77540047
163Abnormality of cells of the erythroid lineage (HP:0012130)1.77223717
164Redundant skin (HP:0001582)1.76966244
165Muscle fiber atrophy (HP:0100295)1.76821988
166Abnormal number of erythroid precursors (HP:0012131)1.76789961
167Broad hallux (HP:0010055)1.76139698
168Abnormality of reticulocytes (HP:0004312)1.76121829
169High anterior hairline (HP:0009890)1.75791689
170Vertebral clefting (HP:0008428)1.75452806
171Abnormalities of placenta or umbilical cord (HP:0001194)1.75434558
172Abnormality of the pons (HP:0007361)1.75225535
173Lower limb hyperreflexia (HP:0002395)1.75145857
174* Squamous cell carcinoma (HP:0002860)1.75128308
175Increased hepatocellular lipid droplets (HP:0006565)1.75045017
176Popliteal pterygium (HP:0009756)1.74591634
177Prominent nose (HP:0000448)1.73235557
178* Ulnar bowing (HP:0003031)1.72776538
179Abnormality of the fingertips (HP:0001211)1.71974724
180Self-mutilation (HP:0000742)1.71676055
181Long palpebral fissure (HP:0000637)1.71673967
182Wide cranial sutures (HP:0010537)1.71644966
183Premature ovarian failure (HP:0008209)1.71114617
184Neonatal respiratory distress (HP:0002643)1.69970150
185Dislocated radial head (HP:0003083)1.69545364
186Lipid accumulation in hepatocytes (HP:0006561)1.69188787
187Flared metaphyses (HP:0003015)1.67651762
188Aplasia/Hypoplasia of the sacrum (HP:0008517)1.67546836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.61949992
2DDR24.36277859
3MAPK153.99724608
4MAP3K63.96410178
5SMG13.36779650
6MAP3K113.07060965
7SIK12.94866567
8TYRO32.71523024
9MST1R2.59400496
10IRAK32.55611336
11MATK2.50273762
12FGR2.50017701
13NME22.43502374
14PINK12.33540128
15CDC72.25888489
16BMX2.23920039
17CDK72.17794162
18WNK42.17352981
19DAPK12.15444273
20UHMK12.03816274
21CDK121.97745122
22PDGFRA1.90873725
23PKN21.86415883
24PIM21.85535036
25PRKD21.83890420
26CSK1.82356908
27YES11.76991663
28DYRK1B1.70563079
29MAP3K101.64378766
30CDK61.60235304
31NEK21.59151658
32PIM11.53705780
33MUSK1.49160020
34CHEK21.48845468
35WEE11.48053486
36ERN11.44006646
37PLK11.42036327
38IRAK21.40728030
39TRPM71.34112207
40LATS21.33388208
41BUB11.30429085
42MAP2K31.23642643
43AKT31.21563695
44DYRK31.20791063
45RPS6KC11.18684663
46RPS6KL11.18684663
47ATR1.17903502
48CDK81.17416082
49SIK21.05397129
50RPS6KB21.05008054
51MAPK111.03619590
52MET1.03432724
53RPS6KA61.01783663
54CDC42BPA0.98452214
55MTOR0.97685011
56TTN0.96320704
57GSK3A0.95455425
58TTK0.94012340
59EPHA20.93669253
60GRK60.93596899
61PRKD30.87711064
62FGFR40.85923602
63PDPK10.85574009
64CDK150.85364503
65CDK11A0.84549421
66CDK40.84039807
67NEK10.83823460
68CHEK10.83317190
69CDK20.82251774
70AURKB0.82001396
71ZAK0.80081870
72CDK180.78657549
73TRIB30.78647564
74PBK0.77822413
75AURKA0.76674581
76STK160.75928277
77EIF2AK10.75374769
78PTK60.73736374
79RPS6KA10.71429974
80ALK0.69110785
81BRAF0.67369443
82ATM0.66728578
83VRK20.66602197
84ARAF0.65987217
85RPS6KA20.65823448
86CCNB10.64663464
87EEF2K0.64068259
88TAOK20.63615295
89STK100.61957568
90BLK0.61818554
91HIPK20.61298849
92CDK140.59538422
93STK30.57253578
94PTK20.56539947
95TLK10.56483043
96TSSK60.55334610
97PHKG10.55149917
98PHKG20.55149917
99CSNK2A10.54425150
100PRKCI0.54220151
101MELK0.53376407
102MAP3K80.52805918
103CDK10.50991567
104PRKAA10.50981143
105MAP2K60.50453210
106MAP2K20.50395147
107CSNK2A20.49621480
108TESK20.47347609
109RAF10.45531103
110RPS6KB10.44016786
111MAPK10.42781228
112MAPK140.41997522
113STK40.41913650
114BRSK20.41823625
115WNK10.41676022
116BRD40.40320975
117LATS10.40206420
118PAK40.39847648
119EGFR0.39830973
120PRPF4B0.38709926
121LMTK20.38410638
122ILK0.38077425
123PAK20.35293586
124MAPKAPK30.34146266
125MAPK30.33863822
126RIPK10.33795600
127ACVR1B0.33387863
128PAK10.33141855
129PDGFRB0.33051242
130MAP4K10.33039360
131MAPK80.32432620
132SRPK10.32285463
133MAPK100.31459419
134LYN0.31180040
135ERBB30.30579378
136KSR20.30559366
137BRSK10.30263098
138MKNK20.29671406
139PRKDC0.29589852
140MARK20.29301586
141AKT20.28216555
142MAPKAPK20.28017052
143CAMK1D0.27749773
144CSNK1E0.27410033
145AKT10.26977639
146GSK3B0.25923071
147FGFR10.24695971
148MKNK10.24599529
149SCYL20.24383763

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.36535881
2DNA replication_Homo sapiens_hsa030304.93876787
3Base excision repair_Homo sapiens_hsa034104.54703163
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.73540977
5Fatty acid biosynthesis_Homo sapiens_hsa000613.68650206
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.11232894
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.00794288
8Spliceosome_Homo sapiens_hsa030402.84577196
9Nucleotide excision repair_Homo sapiens_hsa034202.80542993
10RNA transport_Homo sapiens_hsa030132.76719758
11Homologous recombination_Homo sapiens_hsa034402.58721894
12mRNA surveillance pathway_Homo sapiens_hsa030152.32981059
13Cell cycle_Homo sapiens_hsa041102.27618623
14Fanconi anemia pathway_Homo sapiens_hsa034602.26336522
15One carbon pool by folate_Homo sapiens_hsa006701.91372647
16p53 signaling pathway_Homo sapiens_hsa041151.83889648
17mTOR signaling pathway_Homo sapiens_hsa041501.65440298
18Notch signaling pathway_Homo sapiens_hsa043301.63936386
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63070521
20Ribosome_Homo sapiens_hsa030101.59419436
21Hippo signaling pathway_Homo sapiens_hsa043901.54215844
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49699157
23Biosynthesis of amino acids_Homo sapiens_hsa012301.46730022
24Hedgehog signaling pathway_Homo sapiens_hsa043401.46365710
25Other glycan degradation_Homo sapiens_hsa005111.33016111
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31915867
27Adherens junction_Homo sapiens_hsa045201.26247962
28Arginine and proline metabolism_Homo sapiens_hsa003301.25075577
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21138380
30Sulfur relay system_Homo sapiens_hsa041221.19087006
31Pentose phosphate pathway_Homo sapiens_hsa000301.15177398
32Lysine degradation_Homo sapiens_hsa003101.13993811
33Circadian rhythm_Homo sapiens_hsa047101.13817053
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13542359
35TGF-beta signaling pathway_Homo sapiens_hsa043501.12602546
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12108776
37Bladder cancer_Homo sapiens_hsa052191.12051972
38Oocyte meiosis_Homo sapiens_hsa041141.11821933
39Basal cell carcinoma_Homo sapiens_hsa052171.09559141
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04959669
41N-Glycan biosynthesis_Homo sapiens_hsa005101.04808502
42Sphingolipid metabolism_Homo sapiens_hsa006001.01959464
43RNA polymerase_Homo sapiens_hsa030201.01576126
44Non-small cell lung cancer_Homo sapiens_hsa052231.01098236
45RNA degradation_Homo sapiens_hsa030181.00794368
46Folate biosynthesis_Homo sapiens_hsa007900.98366160
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96054226
48MicroRNAs in cancer_Homo sapiens_hsa052060.95443304
49Viral carcinogenesis_Homo sapiens_hsa052030.95293023
50Pyrimidine metabolism_Homo sapiens_hsa002400.92452983
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91778171
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90170448
53Colorectal cancer_Homo sapiens_hsa052100.86245769
54Wnt signaling pathway_Homo sapiens_hsa043100.86147936
55Basal transcription factors_Homo sapiens_hsa030220.84630482
56Shigellosis_Homo sapiens_hsa051310.84481324
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84400663
58Pyruvate metabolism_Homo sapiens_hsa006200.83858752
59Non-homologous end-joining_Homo sapiens_hsa034500.81899437
60Small cell lung cancer_Homo sapiens_hsa052220.77751034
61Proteasome_Homo sapiens_hsa030500.74851391
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74434950
63Fructose and mannose metabolism_Homo sapiens_hsa000510.72865711
64VEGF signaling pathway_Homo sapiens_hsa043700.72649679
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72613389
66Primary immunodeficiency_Homo sapiens_hsa053400.72479877
67Inositol phosphate metabolism_Homo sapiens_hsa005620.72128515
68Chronic myeloid leukemia_Homo sapiens_hsa052200.71795032
69Carbon metabolism_Homo sapiens_hsa012000.70654734
70Systemic lupus erythematosus_Homo sapiens_hsa053220.68456622
71Vitamin digestion and absorption_Homo sapiens_hsa049770.66361066
72Epstein-Barr virus infection_Homo sapiens_hsa051690.65932917
73Vitamin B6 metabolism_Homo sapiens_hsa007500.64794333
74Herpes simplex infection_Homo sapiens_hsa051680.62160395
75Thyroid cancer_Homo sapiens_hsa052160.61998162
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61284681
77HTLV-I infection_Homo sapiens_hsa051660.60683511
78Selenocompound metabolism_Homo sapiens_hsa004500.57548862
79Alcoholism_Homo sapiens_hsa050340.56774325
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56621943
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.56326872
82Viral myocarditis_Homo sapiens_hsa054160.54999177
83Tight junction_Homo sapiens_hsa045300.53683987
84Acute myeloid leukemia_Homo sapiens_hsa052210.53552382
85Fatty acid metabolism_Homo sapiens_hsa012120.52515673
86Melanogenesis_Homo sapiens_hsa049160.52357881
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50692993
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.50387598
89Purine metabolism_Homo sapiens_hsa002300.50006672
90Legionellosis_Homo sapiens_hsa051340.49395046
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46526308
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.46326744
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.45759621
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45508654
95Glioma_Homo sapiens_hsa052140.45223177
96AMPK signaling pathway_Homo sapiens_hsa041520.43230651
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42898829
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41631106
99Glutathione metabolism_Homo sapiens_hsa004800.38667376
100Dorso-ventral axis formation_Homo sapiens_hsa043200.35455495
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34401311
102Proteoglycans in cancer_Homo sapiens_hsa052050.34327885
103Insulin signaling pathway_Homo sapiens_hsa049100.33514809
104Melanoma_Homo sapiens_hsa052180.33333310
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33129816
106Hepatitis B_Homo sapiens_hsa051610.32293366
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31845457
108Galactose metabolism_Homo sapiens_hsa000520.31159499
109ErbB signaling pathway_Homo sapiens_hsa040120.31022579
110Choline metabolism in cancer_Homo sapiens_hsa052310.30486651
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30380754
112Insulin resistance_Homo sapiens_hsa049310.30306168
113Pathways in cancer_Homo sapiens_hsa052000.29690731
114Prostate cancer_Homo sapiens_hsa052150.29587456
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29001266
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.28925213
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.28450039
118Endometrial cancer_Homo sapiens_hsa052130.28030037
119Arginine biosynthesis_Homo sapiens_hsa002200.27836280
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27517601
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24695845
122Glucagon signaling pathway_Homo sapiens_hsa049220.24265728
123Hepatitis C_Homo sapiens_hsa051600.23696010
124Gap junction_Homo sapiens_hsa045400.23321154
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23102512
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.22481468
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22276186
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21889690
129HIF-1 signaling pathway_Homo sapiens_hsa040660.21606412
130Apoptosis_Homo sapiens_hsa042100.21346613
131Pancreatic cancer_Homo sapiens_hsa052120.20492257
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18366232
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18222265

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